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Articles, 2 records found
Articles 2 records found  
13 p, 3.6 MB Hippocampal Dendritic Spines Are Segregated Depending on Their Actin Polymerization / Domínguez-Iturza, Nuria (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Calvo, María (Advanced Optical Microscopy Unit, Scientific and Technological Centers, Medical School, University of Barcelona) ; Benoist, Marion (INMED, Unite Mixte de Recherche 901, INSERM, Aix-Marseille Université) ; Esteban, José Antonio (Molecular Neurobiology Department, Centro de Biología Molecular Severo Ochoa (CSIC/UAM)) ; Morales, Miguel (Universitat Autònoma de Barcelona. Institut de Neurociències)
Dendritic spines are mushroom-shaped protrusions of the postsynaptic membrane. Spines receive the majority of glutamatergic synaptic inputs. Their morphology, dynamics, and density have been related to synaptic plasticity and learning. [...]
2016 - 10.1155/2016/2819107
Neural plasticity, Vol. 2016 (january 2016)  
18 p, 3.4 MB Learning improvement after PI3K activation correlates with de novo formation of functional small spines / Enriquez-Barreto, Lilian (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Cuesto, Germán (Centro de Investigación Biomédica (La Rioja)) ; Dominguez-Iturza, Nuria (Centro de Investigación Biomédica (La Rioja)) ; Gavilán, Elena (Universidad de Sevilla. Instituto de Biomedicina de Sevilla) ; Ruano, Diego (Universidad de Sevilla. Instituto de Biomedicina de Sevilla) ; Sandi, Carmen (École Polytechnique Fédérale de Lausanne. Brain Mind Institute) ; Fernández-Ruiz, Antonio (Instituto Cajal-CSIC) ; Martín-Vázquez, Gonzalo (Instituto Cajal-CSIC) ; Herreras, Oscar (Instituto Cajal-CSIC) ; Morales, Miguel (Centro de Investigación Biomédica (La Rioja)) ; Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
PI3K activation promotes the formation of synaptic contacts and dendritic spines, morphological features of glutamatergic synapses that are commonly known to be related to learning processes. In this report, we show that in vivo administration of a peptide that activates the PI3K signaling pathway increases spine density in the rat hippocampus and enhances the animals' cognitive abilities, while in vivo electrophysiological recordings show that PI3K activation results in synaptic enhancement of Schaffer and stratum lacunosum moleculare inputs. [...]
2014 - 10.3389/fnmol.2013.00054
Frontiers in molecular neuroscience, Vol. 6 (January 2014) , art. 54  

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2 Domínguez-Iturza, Nuria
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