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1.
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15 p, 2.2 MB |
Recovering What Matters : High Protein Recovery after Endotoxin Removal from LPS-Contaminated Formulations Using Novel Anti-Lipid A Antibody Microparticle Conjugates
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Casonato Melo, Cristiane (Paris Lodron University of Salzburg. Department of Biosciences & Medical Biology) ;
Fux, Alexandra C. (Paris Lodron University of Salzburg. Department of Biosciences & Medical Biology) ;
Himly, Martin (Paris Lodron University of Salzburg. Department of Biosciences & Medical Biology) ;
Bastús, Neus G (Institut Català de Nanociència i Nanotecnologia) ;
Schlahsa, Laura (Miltenyi Biotec B.V. & Co) ;
Siewert, Christiane (Miltenyi Biotec B.V. & Co) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ;
Duschl, Albert (Paris Lodron University of Salzburg. Department of Biosciences & Medical Biology) ;
Gessner, Isabel (Miltenyi Biotec B.V. & Co) ;
Fauerbach, Jonathan A. (Miltenyi Biotec B.V. & Co)
Endotoxins or lipopolysaccharides (LPS), found in the outer membrane of Gram-negative bacterial cell walls, can stimulate the human innate immune system, leading to life-threatening symptoms. Therefore, regulatory limits for endotoxin content apply to injectable pharmaceuticals, and excess LPS must be removed before commercialization. [...]
2023 -  10.3390/ijms241813971
International journal of molecular sciences, Vol. 24, Issue 18 (September 2023) , art. 13971
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2.
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26 p, 1.5 MB |
The Role of common cell culture media supplements on citrate-stabilized gold nanoparticle protein corona formation, aggregation state, and the consequent impact on cellular uptake
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Barbero, Francesco (Institut Català de Nanociència i Nanotecnologia) ;
Michelini, Sara (University of Salzburg. Department of Biosciences) ;
Moriones, Oscar Hernando (Universitat Autònoma de Barcelona) ;
Patarroyo, Javier (Institut Català de Nanociència i Nanotecnologia) ;
Rosell Aluja, Jordi 1955- (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gustà, Muriel F (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vitali, Michele (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martín, Luna (Vall d'Hebron Institut d'Oncologia) ;
Canals, Francesc (Vall d'Hebron Institut d'Oncologia) ;
Duschl, Albert (University of Salzburg. Department of Biosciences) ;
Horejs-Hoeck, Jutta (University of Salzburg. Department of Biosciences) ;
Mondragón, Laura (Institut Català de Nanociència i Nanotecnologia) ;
Bastús, Neus G. (Institut Català de Nanociència i Nanotecnologia) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia)
Sodium citrate-stabilized gold nanoparticles (AuNPs) are destabilized when dispersed in cell culture media (CCMs). This may promote their aggregation and subsequent sedimentation, or under the proper conditions, their interaction with dispersed proteins can lead to the formation of a NP-stabilizing protein corona. [...]
2022 - 10.1021/acs.bioconjchem.2c00232
Bioconjugate chemistry, Vol. 33, issue 8 (Aug. 2022) , p. 1505-1514
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3.
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13 p, 7.0 MB |
Innate memory reprogramming by gold nanoparticles depends on the microbial agents that induce memory
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Swartzwelter, Benjamin J. (Paris Lodron University of Salzburg. Department Biosciences) ;
Michelini, Sara (Paris Lodron University of Salzburg. Department Biosciences) ;
Frauenlob, Tobias (Paris Lodron University of Salzburg. Department Biosciences) ;
Barbero, Francesco (Institut Català de Nanociència i Nanotecnologia) ;
Verde, Alessandro (Consiglio Nazionale delle Ricerche (Nàpols, Itàlia). Istituto di Biochimica e Biologia Cellulare) ;
De Luca, Anna Chiara (Consiglio Nazionale delle Ricerche (Nàpols, Itàlia). Istituto di Biochimica e Biologia Cellulare) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ;
Duschl, Albert (Paris Lodron University of Salzburg. Department Biosciences) ;
Horejs-Hoeck, Jutta (Paris Lodron University of Salzburg. Department Biosciences) ;
Italiani, Paola (Consiglio Nazionale delle Ricerche (Nàpols, Itàlia). Istituto di Biochimica e Biologia Cellulare) ;
Boraschi, Diana (Stazione Zoologica Anton Dohrn)
Innate immune memory, the ability of innate cells to react in a more protective way to secondary challenges, is induced by exposure to infectious and other exogeous and endogenous agents. Engineered nanoparticles are particulate exogenous agents that, as such, could trigger an inflammatory reaction in monocytes and macrophages and could therefore be also able to induce innate memory. [...]
2021 - 10.3389/fimmu.2021.751683
Frontiers in immunology, Vol. 12 (Nov. 2021) , art. 751683
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4.
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17 p, 3.1 MB |
Probing the immune responses to nanoparticles across environmental species. A perspective of the EU Horizon 2020 project PANDORA
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Pinsino, Annalisa (Istituto per la Ricerca e l'Innovazione Biomedica (Palermo)) ;
Bastús, Neus G. (Institut Català de Nanociència i Nanotecnologia) ;
Busquets-Fité, Martí (Applied Nanoparticles S.L.) ;
Canesi, Laura (Università di Genova. Dipartimento di scienze della terra, dell'ambiente e della vita) ;
Cesaroni, Paola (ALTA S.r.l.u) ;
Drobne, Damjana (Univerza V Ljubljani. Oddelek za biologijo) ;
Duschl, Albert (Paris-Lodron University Salzburg. Department of Biosciences) ;
Ewart, Marie-Ann (AvantiCell Science Ltd) ;
Gispert, Ignasi (Applied Nanoparticles S.L.) ;
Horejs-Hoeck, Jutta (Paris-Lodron University Salzburg. Department of Biosciences) ;
Italiani, Paola (Stazione Zoologica Anton Dohrn) ;
Kemmerling, Birgit (Eberhard-Karls University Tübingen. Center for Plant Molecular Biology-ZMBP) ;
Kille, Peter (Cardiff University. School of Biosciences) ;
Procházková, Petra (Institute of Microbiology of the Czech Academy of Sciences) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ;
Spurgeon, David J. (UK Centre for Ecology and Hydrology) ;
Svendsen, Claus (UK Centre for Ecology and Hydrology) ;
Wilde, Colin J. (AvantiCell Science Ltd) ;
Boraschi, Diana (Istituto di Biochimica e Biologia Cellulare (Nàpols))
Understanding how engineered nanomaterials affect immune responses of living organisms requires a strong collaborative effort between immunologists, toxicologists, ecologists, physiologists, inorganic chemists, nanomaterial scientists and experts in law and risk management. [...]
2020 - 10.1039/d0en00732c
Environmental science. Nano, Vol. 7, issue 11 (Nov. 2020) , p. 3216-3232
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5.
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26 p, 2.5 MB |
Addressing nanomaterial immunosafety by evaluating innate immunity across living species
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Boraschi, Diana (Istituto di Biochimica e Biologia Cellulare (Nàpols)) ;
Alijagic, Andi (Istituto per la Ricerca e l'Innovazione Biomedica (Palermo)) ;
Auguste, Manon (Università di Genova. Dipartimento di scienze della terra, dell'ambiente e della vita) ;
Barbero, Francesco (Institut Català de Nanociència i Nanotecnologia) ;
Ferrari, Eleonora (ZMBP Eberhard-Karls University Tübingen. Center for Plant Molecular Biology) ;
Hernadi, Szabolcs (Cardiff University. School of Biosciences) ;
Mayall, Craig (University of Liubljana. Department of Biology) ;
Michelini, Sara (Paris-Lodron-University Salzburg. Department of Biosciences) ;
Navarro Pacheco, Natividad I. (Czech Academy of Sciences. Institute of Microbiology) ;
Prinelli, Alessandra (AvantiCell Science Ltd) ;
Swart, Elmer (UK Centre for Ecology and Hydrology) ;
Swartzwelter, Benjamin J. (Istituto di Biochimica e Biologia Cellulare (Nàpols)) ;
Bastús, Neus G. (Institut Català de Nanociència i Nanotecnologia) ;
Canesi, Laura (Università di Genova. Dipartimento di scienze della terra, dell'ambiente e della vita) ;
Drobne, Damjana (University of Liubljana. Department of Biology) ;
Duschl, Albert (Paris-Lodron-University Salzburg. Department of Biosciences) ;
Ewart, Marie-Ann (AvantiCell Science Ltd) ;
Horejs-Hoeck, Jutta (Paris-Lodron-University Salzburg. Department of Biosciences) ;
Italiani, Paola (Istituto di Biochimica e Biologia Cellulare (Nàpols)) ;
Kemmerling, Birgit (Center for Plant Molecular Biology - ZMBP. Eberhard-Karls University Tübingen) ;
Kille, Peter (Cardiff University. School of Biosciences) ;
Prochazkova, Petra (Czech Academy of Sciences. Institute of Microbiology) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ;
Spurgeon, David J. (UK Centre for Ecology and Hydrology) ;
Svendsen, Claus (UK Centre for Ecology and Hydrology) ;
Wilde, Colin J. (AvantiCell Science Ltd) ;
Pinsino, Annalisa (Istituto per la Ricerca e l'Innovazione Biomedica (Palermo))
The interaction of a living organism with external foreign agents is a central issue for its survival and adaptation to the environment. Nanosafety should be considered within this perspective, and it should be examined that how different organisms interact with engineered nanomaterials (NM) by either mounting a defensive response or by physiologically adapting to them. [...]
2020 - 10.1002/smll.202000598
Small, Vol. 16, issue 21 (May 2020) , art. 2000598
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6.
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19 p, 7.4 MB |
Gold nanoparticles (AuNPs) impair LPS-driven immune responses by promoting a tolerogenic-like dendritic cell phenotype with altered endosomal structures
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Michelini, Sara (Paris-Lodron University Salzburg) ;
Barbero, Francesco (Institut Català de Nanociència i Nanotecnologia) ;
Prinelli, Alessandra (AvantiCell Science Ltd) ;
Steiner, Philip (University Salzburg) ;
Weiss, Richard (Paris-Lodron University Salzburg) ;
Verwanger, Thomas (Paris-Lodron University Salzburg) ;
Andosch, Ancuela (Paris-Lodron University Salzburg) ;
Lütz-Meindl, Ursula (Paris-Lodron University Salzburg) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ;
Drobne, Damjana (Univerza V Ljubljani) ;
Duschl, Albert (Paris-Lodron University Salzburg) ;
Horejs-Hoeck, Jutta (Paris-Lodron University Salzburg)
Dendritic cells (DCs) shape immune responses by influencing T-cell activation. Thus, they are considered both an interesting model for studying nano-immune interactions and a promising target for nano-based biomedical applications. [...]
2021 - 10.1039/d0nr09153g
Nanoscale, Vol. 13, Issue 16 (April 2021) , p. 7648-7666
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7.
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12 p, 1.5 MB |
Altered characteristics of silica nanoparticles in bovine and human serum : The importance of nanomaterial characterization prior to its toxicological evaluation
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Izak-Nau, Emilia (University of Salzburg. Department of Molecular Biology) ;
Voetz, Matthias (Bayer Technology Services GmbH) ;
Eiden, Stefanie (Bayer Technology Services GmbH) ;
Duschl, Albert (University of Salzburg. Department of Molecular Biology) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia)
Background: Many toxicological studies on silica nanoparticles (NPs) have been reported, however, the literature often shows various conclusions concerning the same material. This is mainly due to a lack of sufficient NPs characterization as synthesized as well as in operando. [...]
2013 - 10.1186/1743-8977-10-56
Particle and fibre toxicology, Vol. 10 (November 2013) , art. 56
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8.
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15 p, 2.2 MB |
Shape matters : Effects of silver nanospheres and wires on human alveolar epithelial cells
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Stoehr, Linda C. (University of Salzburg. Department of Molecular Biology) ;
González, Edgar E. (Institut Català de Nanociència i Nanotecnologia) ;
Stampfl, Andreas (Helmholtz Centre Munich) ;
Casals, Eudald (Institut Català de Nanociència i Nanotecnologia) ;
Duschl, Albert (University of Salzburg. Department of Molecular Biology) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ;
Oostingh, G. J. (University of Salzburg. Department of Molecular Biology)
Background: In nanotoxicology, the exact role of particle shape, in relation to the composition, on the capacity to induce toxicity is largely unknown. We investigated the toxic and immunotoxic effects of silver wires (length: 1. [...]
2011 - 10.1186/1743-8977-8-36
Particle and fibre toxicology, Vol. 8 (December 2011) , art. 36
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9.
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18 p, 2.1 MB |
The oxidative potential of differently charged silver and gold nanoparticles on three human lung epithelial cell types
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Schlinkert, Paul (Paris Lodron-University of Salzburg. Department of Molecular Biology) ;
Casals, Eudald (Institut Català de Nanociència i Nanotecnologia) ;
Boyles, Matthew S. P. (Paris Lodron-University of Salzburg. Department of Molecular Biology) ;
Tischler, Ulrike (Paris Lodron-University of Salzburg. Department of Molecular Biology) ;
Hornig, Eva (Paris Lodron-University of Salzburg. Department of Molecular Biology) ;
Tran Thi Thanh, Ngoc (Institut Català de Nanociència i Nanotecnologia) ;
Zhao, Jiayuan (Institute for Work and Health) ;
Himly, Martin (Paris Lodron-University of Salzburg. Department of Molecular Biology) ;
Riediker, Michael (Institue for Occupational Medicine) ;
Oostingh, G. J. (Salzburg University of Applied Sciences) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ;
Duschl, Albert (Paris Lodron-University of Salzburg. Department of Molecular Biology)
Background: Nanoparticle (NPs) functionalization has been shown to affect their cellular toxicity. To study this, differently functionalized silver (Ag) and gold (Au) NPs were synthesised, characterised and tested using lung epithelial cell systems. [...]
2015 - 10.1186/s12951-014-0062-4
Journal of nanobiotechnology, Vol. 13 (January 2015) , art. 1
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10.
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20 p, 3.7 MB |
Bacterial endotoxin (lipopolysaccharide) binds to the surface of gold nanoparticles, interferes with biocorona formation and induces human monocyte inflammatory activation
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Li, Yang (Hebei Normal University) ;
Shi, Zhenzhen (Kansas State University. Department of Anatomy and Physiology) ;
Radauer-Preiml, Isabella (University of Salzburg. Department of Molecular Biology) ;
Andosch, Ancuela (University of Salzburg. Department of Molecular Biology) ;
Casals, Eudald (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Luetz-Meindl, Ursula (University of Salzburg. Department of Molecular Biology) ;
Cobaleda-Siles, Macarena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Lin, Zhoumeng (Kansas State University. Department of Anatomy and Physiology) ;
Jaberi-Douraki, Majid (Kansas State University. Department of Anatomy and Physiology) ;
Italiani, Paola (National Research Council) ;
Horejs-Hoeck, Jutta (University of Salzburg. Department of Molecular Biology) ;
Himly, Martin (University of Salzburg. Department of Molecular Biology) ;
Monteiro-Riviere, Nancy A. (Kansas State University. Department of Anatomy and Physiology) ;
Duschl, Albert (University of Salzburg. Department of Molecular Biology) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ;
Boraschi, Diana (National Research Council)
Nanoparticles (NPs) are easily contaminated by bacterial endotoxin (lipopolysaccharide [LPS]). The presence of LPS can be responsible for many immune/inflammatory effects attributed to NPs. In this study, we examined the effects of LPS adsorption on the NP surface on the formation of a biocorona in biological fluids and on the subsequent inflammation-inducing activity of NPs. [...]
2017 - 10.1080/17435390.2017.1401142
Nanotoxicology, Vol. 11, Issue 9-10 (December 2017) , p. 1157-1175
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