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15 p, 1007.8 KB An original phylogenetic approach identified mitochondrial haplogrou,p T1a1 as inversely associated with breast cancer risk in BRCA2 mutation carriers / Blein, Sophie (Université Lyon 1) ; Bardel, Claire (Université Claude Bernard Lyon 1) ; Danjean, Vincent (INRIA Rhône-Alpes (França)) ; McGuffog, Lesley (University of Cambridge) ; Healey, Sue (QIMR Berghofer (Australia)) ; Barrowdale, Daniel (University of Cambridge) ; Lee, Andrew (University of Cambridge) ; Dennis, Joe (University of Cambridge) ; Kuchenbaecker, Karoline B. (University of Cambridge) ; Soucy, Penny (Laval University (Canadà)) ; Terry, Mary Beth (Columbia University) ; Chung, Wendy (Columbia University College of Physicians and Surgeons) ; Goldgar, David E. (University of Utah School of Medicine) ; Buys, Saundra (University of Utah School of Medicine) ; Janavicius, Ramunas (State Research Institute (Lituania)) ; Tihomirova, Laima (Latvian Biomedical Research and Study Centre) ; Tung, Nadine (Beth Israel Deaconess Medical Center (Estats Units d'Amèrica)) ; Dorfling, Cecilia M. (University of Pretoria) ; van Rensburg, Elizabeth J. (University of Pretoria (Estats Units d'Amèrica)) ; Neuhausen, Susan L. (Beckman Research Institute of City of Hope (Duarte, Estats Units d'Amèrica)) ; Ding, Yuan Chun (Beckman Research Institute of City of Hope (Duarte, Estats Units d'Amèrica)) ; Gerdes, Anne-Marie (Copenhagen University Hospital) ; Ejlertsen, Bent (Copenhagen University Hospital) ; Nielsen, Finn C. (Copenhagen University Hospital) ; Hansen, Thomas V. O. (Copenhagen University Hospital) ; Osorio, Ana (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Benitez, Javier (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Conejero, Raquel Andrés (Hospital Clínico Universitario "Lozano Blesa" de Zaragoza) ; Segota, Ena (Clinical Cancer Genetics Community Research Network(Estats Units d'Amèrica)) ; Weitzel, Jeffrey N. (Division of Clinical Cancer Genetics(Estats Units d'Amèrica)) ; Thelander, Margo (Walnut Creek (Estats Units d'Amèrica)) ; Peterlongo, Paolo (Istituto FIRC di Oncologia Molecolare) ; Radice, Paolo (Istituto di Ricovero e Cura a Carattere Scientifico) ; Pensotti, Valeria (Cogentech Cancer Genetic Test Laboratory (Itàlia)) ; Dolcetti, Riccardo (Centro di Riferimento Oncologico (Itàlia)) ; Bonanni, Bernardo (Istituto Europeo di Oncologia (Itàlia)) ; Peissel, Bernard (Istituto di Ricovero e Cura a Carattere Scientifico (Itàlia)) ; Zaffaroni, Daniela (Istituto di Ricovero e Cura a Carattere Scientifico (Itàlia)) ; Scuvera, Giulietta (Istituto di Ricovero e Cura a Carattere Scientifico (Itàlia)) ; Manoukian, Siranoush (Istituto di Ricovero e Cura a Carattere Scientifico (Itàlia)) ; Varesco, Liliana (Istituto di Ricovero e Cura a Carattere Scientifico (Itàlia)) ; Capone, Gabriele L. (University of Florence, Florence) ; Papi, Laura (University of Florence, Florence) ; Ottini, Laura (Sapienza University) ; Yannoukakos, Drakoulis (Aristotle University of Thessaloniki School of Medicine) ; Konstantopoulou, Irene (Aghia Paraskevi Attikis) ; Garber, Judy (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica)) ; Hamann, Ute (Deutsches Krebsforschungszentrum) ; Donaldson, Alan (St Michael's Hospital) ; Brady, Angela (Kennedy-Galton Centre) ; Brewer, Carole (Royal Devon & Exeter Hospital (Exeter, Regne Unit)) ; Foo, Claire (Liverpool Women's NHS Foundation Trust) ; Evans, D. Gareth (Central Manchester University Hospitals NHS Foundation Trust) ; Frost, Debra (University of Cambridge, Worts Causeway) ; Eccles, Diana M (University Hospital Southampton NHS Foundation Trust (Regne Unit)) ; Douglas, Fiona (Institute of Human Genetics, Northern Genetic Service (Regne Unit)) ; Cook, Jackie (Sheffield Children's Hospital (Sheffield, Regne Unit)) ; Adlard, Julian (Yorkshire Regional Genetics Service) ; Barwell, Julian (Leicestershire Clinical Genetics Service) ; Walker, Lisa (Churchill Hospital) ; Izatt, Louise (St Thomas' NHS Foundation Trust) ; Side, Lucy E. (Great Ormond Street Hospital for Children (Londres)) ; Kennedy, M. John (St. James's Hospital ( Dublín, Irlanda)) ; Tischkowitz, Marc (Addenbrookes Hospital (Cambridge, Regne Unit)) ; Rogers, Mark T. (University Hospital of Wales) ; Porteous, Mary E. (Western General Hospital) ; Morrison, Patrick J. (Belfast City Hospital, Lisburn Road) ; Platte, Radka (University of Cambridge) ; Eeles, Ros (The Institute of Cancer Research and Royal Marsden NHS Foundation Trust) ; Davidson, Rosemarie (Yorkhill Hospitals) ; Hodgson, Shirley (St George's University of London) ; Cole, Trevor (Birmingham Women's Hospital) ; Godwin, Andrew K. (DUniversity of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160 USA) ; Isaacs, Claudine (Lombardi Comprehensive Cancer Center, MedStar Georgetown University Hospital, 3800 Reservoir Road NW, Washington, DC 20057 USA) ; Claes, Kathleen (Center for Medical Genetics, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium) ; De Leeneer, Kim (Center for Medical Genetics, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium) ; Meindl, Alfons (Division of Tumor Genetics, Department of Gynaecology and Obstetrics, University Hospital Klinikum Rechts der Isar, Technische Universität München, Ismaninger Strasse 22, 81675 Munich, Germany) ; Gehrig, Andrea (Center of Familial Breast and Ovarian Cancer, Department of Medical Genetics, Institut für Humangenetik, Biozentrum, Universität Würzburg, Am Hubland, 97074 Würzburg, Germany) ; Wappenschmidt, Barbara (Center for Molecular Medicine Cologne (CMMC), University of Cologne, Robert-Koch-Strasse 21, 50931 Cologne, Germany) ; Sutter, Christian (Heidelberg University Hospital (Alemanya)) ; Engel, Christoph (Institute for Medical Informatics, Statistics and Epidemiology, Medical Faculty, University of Leipzig, Leipzig, Germany) ; Niederacher, Dieter (University Hospital of Düsseldorf (Alemanya)) ; Steinemann, Doris (Institute of Cell and Molecular Pathology, Centre for Pathology and Forensic and Genetic Medicine, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany) ; Plendl, Hansjoerg (Institute of Human Genetics, University Medical Center Schleswig-Holstein, Campus Kiel, Arnold-Heller-Strasse 3, D-24105 Kiel, Germany) ; Kast, Karin (Department of Gynecology and Obstetrics, University Hospital Carl Gustav Carus of Dresden, Technical University Dresden, Dresden, Germany) ; Rhiem, Kerstin (Center for Molecular Medicine Cologne (CMMC), University of Cologne, Robert-Koch-Strasse 21, 50931 Cologne, Germany) ; Ditsch, Nina (Division of Tumor Genetics, Department of Gynaecology and Obstetrics, University Hospital Klinikum Rechts der Isar, Technische Universität München, Ismaninger Strasse 22, 81675 Munich, Germany) ; Arnold, Norbert (Department of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, Campus Kiel, Arnold-Heller-Strasse 3, D-24105 Kiel, Germany) ; Varon-Mateeva, Raymonda (Institute of Medical Genetics and Human Genetics, Campus Virchow-Klinikum, Charité Berlin - Universtitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany) ; Schmutzler, Rita K. (German Consortium of Hereditary Breast and Ovarian Cancer (GC-HBOC), Cologne, Germany) ; Preisler-Adams, Sabine (University Hospital of Münster (Alemanya)) ; Markov, Nadja Bogdanova (University Hospital of Münster (Alemanya)) ; Wang-Gohrke, Shan (University Hospital of Ulm (Alemanya)) ; De Pauw, Antoine (Institut Curie. Department of Tumour Biology) ; Lefol, Cédrick (Department of Tumour Biology, Institut Curie, 26 rue d'Ulm 75248, Paris, cedex 05 France) ; Lasset, Christine (Unité de Prévention et d'Épidémiologie Génétique, Centre Léon Bérard, 28 rue Laenned, 69008 Lyon, France) ; Leroux, Dominique (Institut Albert Bonniot - Inserm U823, Université Joseph Fourier, Rond-point de la Chantourne, 38706 La Tronche, France) ; Rouleau, Etienne (Laboratoire d'Oncogénétique, Hôpital René Huguenin, Institut Curie, 35 rue Dailly, 92210 Saint-Cloud, France) ; Damiola, Francesca (Centre National de la Recherche Scientifique (França)) ; Dreyfus, Hélène (Institut Albert Bonniot - Inserm U823, Université Joseph Fourier, Rond-point de la Chantourne, 38706 La Tronche, France) ; Barjhoux, Laure (Centre National de la Recherche Scientifique (França)) ; Golmard, Lisa (Department of Tumour Biology, Institut Curie, 26 rue d'Ulm 75248, Paris, cedex 05 France) ; Uhrhammer, Nancy (Département d'Oncogénétique, Centre Jean Perrin, Université de Clermont-Ferrand, 58 rue Montalembert, BP 392, 63011 Clermont-Ferrand, France) ; Bonadona, Valérie (Unité de Prévention et d'Épidémiologie Génétique, Centre Léon Bérard, 28 rue Laenned, 69008 Lyon, France) ; Sornin, Valérie (Centre National de la Recherche Scientifique (França)) ; Bignon, Yves-Jean (Département d'Oncogénétique, Centre Jean Perrin, Université de Clermont-Ferrand, 58 rue Montalembert, BP 392, 63011 Clermont-Ferrand, France) ; Carter, Jonathan (Gynaecological Oncology, Sydney Cancer Centre, Royal Prince Alfred Hospital and University of Sydney, Missenden Road, Camperdown, NSW 2050 Australia) ; Van Le, Linda (Gynecologic Oncology Group, Department of OB-GYN, University of North Carolina at Chapel Hill, 103B Physicians' Office Building, CB# 7572, Chapel Hill, NC 27599-7572 USA) ; Piedmonte, Marion (Gynecologic Oncology Group Statistical and Data Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263-0001 USA) ; DiSilvestro, Paul A. (Women & Infants Hospital, 1 Blackstone Place, Providence, RI 02905 USA) ; De la Hoya, Miguel (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ; Caldes, Trinidad (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ; Nevanlinna, Heli (Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Biomedicum Helsinki, PO Box 700, 00029 Helsinki, Finland) ; Aittomäki, Kristiina (Department of Clinical Genetics, Helsinki University Central Hospital, Biomedicum Helsinki 1, Haartmaninkatu 8, 00290 Helsinki, Finland) ; Jager, Agnes (Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, the Netherlands) ; van den Ouweland, Ans M. W. (Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, the Netherlands) ; Kets, Carolien M. (Radboud University Medical Centre. Department of Human Genetics) ; Aalfs, Cora M. (Department of Clinical Genetics, Academic Medical Center, Amsterdam, the Netherlands) ; van Leeuwen, Flora E. (The Netherlands Cancer Institute (Amsterdam, Països Baixos)) ; Hogervorst, Frans B. L. (Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, the Netherlands) ; Meijers-Heijboer, Hanne E. J. (Department of Clinical Genetics, VU University Medical Center Amsterdam, De Boelelaan 1118, 1081 HV Amsterdam, the Netherlands) ; Oosterwijk, Jan C. (Department of Genetics, University Medical Center, Groningen University, Groningen, the Netherlands) ; van Roozendaal, Kees E. P. (Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, the Netherlands) ; Rookus, Matti A. (The Netherlands Cancer Institute (Amsterdam, Països Baixos)) ; Devilee, Peter (Department of Pathology, Leiden University Medical Center, PO Box 9600, 2300 RC L1Q Leiden, the Netherlands) ; van der Luijt, Rob B. (Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands) ; Olah, Edith (Department of Molecular Genetics, National Institute of Oncology, Ráth György u 7-9, PO Box 1525 Budapest PF 21, 1122 Budapest, Hungary) ; Diez, Orland (Vall d'Hebron Institut d'Oncologia) ; Teulé, Alex (Institut d'Investigació Biomèdica de Bellvitge) ; Lazaro, Conxi (Institut d'Investigació Biomèdica de Bellvitge) ; Blanco Guillermo, Ignacio (Institut d'Investigació Biomèdica de Bellvitge) ; Del Valle, Jesús (Institut d'Investigació Biomèdica de Bellvitge) ; Jakubowska, Anna (Department of Genetics and Pathomorphology, Faculty of Medicine and Dentistry, Pomeranian Medical University, al Powstancow Wlkp 72, 70-111 Szczecin, Poland) ; Sukiennicki, Grzegorz (Department of Genetics and Pathomorphology, Faculty of Medicine and Dentistry, Pomeranian Medical University, al Powstancow Wlkp 72, 70-111 Szczecin, Poland) ; Gronwald, Jacek (Department of Genetics and Pathomorphology, Faculty of Medicine and Dentistry, Pomeranian Medical University, al Powstancow Wlkp 72, 70-111 Szczecin, Poland) ; Lubinski, Jan (Department of Genetics and Pathomorphology, Faculty of Medicine and Dentistry, Pomeranian Medical University, al Powstancow Wlkp 72, 70-111 Szczecin, Poland) ; Durda, Katarzyna (Department of Genetics and Pathomorphology, Faculty of Medicine and Dentistry, Pomeranian Medical University, al Powstancow Wlkp 72, 70-111 Szczecin, Poland) ; Jaworska-Bieniek, Katarzyna (Department of Genetics and Pathomorphology, Faculty of Medicine and Dentistry, Pomeranian Medical University, al Powstancow Wlkp 72, 70-111 Szczecin, Poland) ; Agnarsson, Bjarni A. (Landspitali University Hospital (Reykjavík, Islàndia)) ; Maugard, Christine (Laboratoire de diagnostic génétique et Service d'Onco-hématologie, Les Hopitaux Universitaire de Strasbourg, Nouvel Hôpital Civil, 1 place de l'Hôpital, BP 426, 67091 Strasbourg, France) ; Amadori, Alberto (Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto (IOV) - Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), via Gattamelata 64, 35128 Padua, Italy) ; Montagna, Marco (Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto (IOV) - Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), via Gattamelata 64, 35128 Padua, Italy) ; Teixeira, Manuel R. (Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal) ; Spurdle, Amanda B. (Department of Genetics and Computational Biology, QIMR Berghofer, Brisbane, Australia) ; Foulkes, William (Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, 546 Pine Avenue West, Montreal, QC J2W 1S6 Canada) ; Olswold, Curtis (Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905 USA) ; Lindor, Noralane M. (Department of Health Sciences Research, Mayo Clinic, 13400 East Shea Boulevard, Scottsdale, AZ 85259 USA) ; Pankratz, Vernon S. (Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905 USA) ; Szabo, Csilla I (National Human Genome Research Institute, National Institutes of Health, Building 31, Room 4B09, 31 Center Drive, MSC 2152, 9000 Rockville Pike, Bethesda, MD 20892-2152 USA) ; Lincoln, Anne (Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 USA) ; Jacobs, Lauren (Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 USA) ; Corines, Marina (Memorial Sloan-Kettering Cancer Center, New York) ; Robson, Mark (Clinical Genetics Research Laboratory, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 USA) ; Vijai, Joseph (Clinical Genetics Research Laboratory, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 USA) ; Berger, Andreas (Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH - Wien, Währinger Gürtel 18-20, 1090 Vienna, Austria) ; Fink-Retter, Anneliese (Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH - Wien, Währinger Gürtel 18-20, 1090 Vienna, Austria) ; Singer, Christian F. (Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH - Wien, Währinger Gürtel 18-20, 1090 Vienna, Austria) ; Rappaport, Christine (Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH - Wien, Währinger Gürtel 18-20, 1090 Vienna, Austria) ; Kaulich, Daphne Geschwantler (Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH - Wien, Währinger Gürtel 18-20, 1090 Vienna, Austria) ; Pfeiler, Georg (Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH - Wien, Währinger Gürtel 18-20, 1090 Vienna, Austria) ; Tea, Muy-Kheng (Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH - Wien, Währinger Gürtel 18-20, 1090 Vienna, Austria) ; Greene, Mark H. (Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD USA) ; Mai, Phuong L. (Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD USA) ; Rennert, Gad (Ruth and Bruce Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, 2 Horev Street, 34362 Haifa, Israel) ; Imyanitov, Evgeny N. (NN Petrov Institute of Oncology, 68 Leningradskaya Street, Pesochny, 197758 St Petersburg Russia) ; Mulligan, Anna Marie (Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael's Hospital, 209 Victoria Street, Toronto, ON M5B 1T8 Canada) ; Glendon, Gord (Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital Joseph and Wolf Lebovic Health Complex, 600 University Avenue, Toronto, ON M5G 1X5 Canada) ; Andrulis, Irene L. (Department of Molecular Genetics, University of Toronto, Medical Science Building, Room 4386, 1 King's College Circle, Toronto, ON M5S 1A8 Canada) ; Tchatchou, Sandrine (Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital Joseph and Wolf Lebovic Health Complex, 600 University Avenue, Toronto, ON M5G 1X5 Canada) ; Toland, Amanda Ewart (The Ohio State University Comprehensive Cancer Center - Arthur G James Cancer Hospital and Richard J Solove Research Institute (OSUCCC - James), 460 West 10th Avenue, Columbus, OH 43210 USA) ; Pedersen, Inge Sokilde (Aalborg University Hospital (Dinamarca)) ; Thomassen, Mads (Odense University Hospital (Dinamarca)) ; Kruse, Torben A. (Odense University Hospital (Dinamarca)) ; Jensen, Uffe Birk (Aarhus University Hospital (Aarhus, Dinamarca)) ; Caligo, Maria (Laboratorio di Genetica Oncologica, Divisione di Anatomia Patologica e di Diagnostica Molecolare ed Ultrastrutturale, Azienda Ospedaliero Universitaria Pisana - Ospedale S Chiara, via Roma 67, 56126 Pisa, Italy) ; Friedman, Eitan (Sheba Laboratory of Molecular Genetics, The Danek Gertner Institute of Human Genetics, Sheba Medical Center, Tel Hashomer, Ramat Gan, 52621 Tel Aviv, Israel) ; Zidan, Jamal (Institute of Oncology, Rivka Ziv Medical Center, Maimonides, 13100 Safed, Israel) ; Laitman, Yael (Sheba Laboratory of Molecular Genetics, The Danek Gertner Institute of Human Genetics, Sheba Medical Center, Tel Hashomer, Ramat Gan, 52621 Tel Aviv, Israel) ; Lindblom, Annika (Karolinska University Hospital and Karolinska Institutet (Suècia)) ; Melin, Beatrice (Oncology, Department of Radiation Sciences, Umeå University, SE-901 87 Umeå, Sweden) ; Arver, Brita (Karolinska University Hospital and Karolinska Institutet (Suècia)) ; Loman, Niklas (Division of Oncology and Pathology, Department of Clinical Sciences, Lund University Hospital, Barngatan 2B, SE-221 85 Lund, Sweden) ; Rosenquist, Richard (Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, 751 85 Uppsala, Sweden) ; Olopade, Olufunmilayo I (Center for Clinical Cancer Genetics and Global Health, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637 USA) ; Nussbaum, Robert L. (Department of Medicine and Genetics, University of California, San Francisco, CA USA) ; Ramus, Susan J. (Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Norris Comprehensive Cancer Center, NOR-4435, Los Angeles, CA 90089-9175 USA) ; Nathanson, Katherine L. (Department of Medicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, 3535 Market Street, Suite 750, Philadelphia, PA 19104-3309 USA) ; Domchek, Susan M. (Department of Medicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, 3535 Market Street, Suite 750, Philadelphia, PA 19104-3309 USA) ; Rebbeck, Timothy R. (Department of Epidemiology and Biostatistics, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, 3535 Market Street, Suite 750, Philadelphia, PA 19104-3309 USA) ; Arun, Banu K. (Division of Cancer Medicine, Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Unit 1354, PO Box 301439, Houston, TX 77230-1439 USA) ; Mitchell, Gillian (Sir Peter MacCallum Department of Oncology, The University of Melbourne, Level 5, 161 Barry Street, Parkville, 3010 VIC Australia) ; Karlan, Beth Y (Cedars Sinai Heart Institute (Los Angeles, Estats Units d'Amèrica)) ; Lester, Jenny (Cedars Sinai Heart Institute (Los Angeles, Estats Units d'Amèrica)) ; Orsulic, Sandra (Cedars Sinai Heart Institute (Los Angeles, Estats Units d'Amèrica)) ; Stoppa-Lyonnet, Dominique (Université Paris Descartes) ; Thomas, Gilles (Institut National du Cancer (INCa), La Fondation Synergie Lyon Cancer, Centre Léon Bérard, 28 rue Laënnec, 69008 Lyon, Cedex 08 France) ; Simard, Jacques (Centre de recherche du Centre hospitalier universitaire de Québec, Laval University, Charlesbourg, PQ Canada) ; Couch, Fergus J. (Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905 USA) ; Offit, Kenneth (Clinical Genetics Research Laboratory, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 USA) ; Easton, Douglas F. (University of Cambridge. Centre for Cancer Genetic Epidemiology) ; Chenevix-Trench, Georgia (Department of Genetics and Computational Biology, QIMR Berghofer, Brisbane, Australia) ; Antoniou, Antonis C. (University of Cambridge. Centre for Cancer Genetic Epidemiology) ; Mazoyer, Sylvie (Université Lyon 1, 69100 Villeurbanne, France) ; Phelan, Catherine M. (Department of Cancer Epidemiology, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612 USA) ; Sinilnikova, Olga M. (Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon - Centre Léon Bérard, 69373 Lyon, Cedex 08 France) ; Cox, David G. (Université Lyon 1, 69100 Villeurbanne, France) ; Universitat Autònoma de Barcelona
Individuals carrying pathogenic mutations in the BRCA1 and BRCA2 genes have a high lifetime risk of breast cancer. BRCA1 and BRCA2 are involved in DNA double-strand break repair, DNA alterations that can be caused by exposure to reactive oxygen species, a main source of which are mitochondria. [...]
2015 - 10.1186/s13058-015-0567-2
Breast cancer research, Vol. 17 (april 2015)  
2.
18 p, 1.0 MB Assessing Associations between the AURKA-HMMR-TPX2-TUBG1 Functional Module and Breast Cancer Risk in BRCA1/2 Mutation Carriers / Blanco Guillermo, Ignacio (Institut d'Investigació Biomèdica de Bellvitge) ; Kuchenbaecker, Karoline (University of Cambridge) ; Cuadras, Daniel (Institut d'Investigació Biomèdica de Bellvitge) ; Wang, Xianshu (Mayo Clinic, Rochester, United States of America) ; Barrowdale, Daniel (University of Cambridge) ; de Garibay, Gorka Ruiz (Institut d'Investigació Biomèdica de Bellvitge) ; Librado, Pablo (Universitat de Barcelona) ; Sánchez-Gracia, Alejandro (Universitat de Barcelona) ; Rozas, Julio (Universitat de Barcelona) ; Bonifaci, Núria (Institut d'Investigació Biomèdica de Bellvitge) ; McGuffog, Lesley (University of Cambridge) ; Pankratz, Vernon S. (Mayo Clinic, Rochester, Minnesota) ; Islam, Abul (University of Dhaka) ; Mateo, Francesca (Institut d'Investigació Biomèdica de Bellvitge) ; Berenguer-Llergo, Antoni (Institut d'Investigació Biomèdica de Bellvitge) ; Petit Montserrat, Anna (Institut d'Investigació Biomèdica de Bellvitge) ; Català, Isabel (Institut d'Investigació Biomèdica de Bellvitge) ; Brunet, Joan (Institut d'Investigació Biomèdica de Girona) ; Feliubadaló, Lidia (Institut d'Investigació Biomèdica de Bellvitge) ; Tornero, Eva (Institut d'Investigació Biomèdica de Bellvitge) ; Benitez, Javier (Centro Nacional de Investigaciones Oncológicas) ; Osorio, Ana (Centro Nacional de Investigaciones Oncológicas) ; Ramon y Cajal, Teresa (Institut d'Investigació Biomèdica Sant Pau) ; Aittomäki, Kristiina (Helsinki University Central Hospital) ; Arun, Banu K. (University of Texas) ; Toland, Amanda E. (The Ohio State University, Columbus) ; Karlan, Beth Y. (Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Los Angeles) ; Walsh, Christine (Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Los Angeles) ; Lester, Jenny (Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Los Angeles) ; Greene, Mark H. (National Cancer Institute, Maryland, Rockville) ; Mai, Phuong L. (National Cancer Institute, Maryland, Rockville) ; Nussbaum, Robert L. (University of California San Francisco, San Francisco) ; Andrulis, Irene L. (Samuel Lunenfeld Research Institute, Mount Sinai Hospital, and Departments of Molecular Genetics and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada) ; Domchek, Susan M. (The University of Pennsylvania School of Medicine, Philadelphia) ; Nathanson, Katherine L. (The University of Pennsylvania School of Medicine, Philadelphia) ; Rebbeck, Timothy R. (Abramson Cancer Center and Center for Clinical Epidemiology and Biostatistics, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America) ; Barkardottir, Rosa B. (Landspitali University Hospital (Reykjavík, Islàndia)) ; Jakubowska, Anna (Pomeranian Medical University, Szczecin) ; Lubinski, Jan (Pomeranian Medical University, Szczecin) ; Durda, Katarzyna (Pomeranian Medical University, Szczecin) ; Jaworska-Bieniek, Katarzyna (Pomeranian Medical University, Szczecin) ; Claes, Kathleen (Ghent University, Ghent) ; Van Maerken, Tom (Ghent University, Ghent) ; Diez, Orland (Vall d'Hebron Institut d'Oncologia) ; Hansen, Thomas V. (Copenhagen University Hospital) ; Jønson, Lars (Copenhagen University Hospital) ; Gerdes, Anne-Marie (Copenhagen University Hospital) ; Ejlertsen, Bent (Copenhagen University Hospital) ; De la Hoya, Miguel (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ; Caldes, Trinidad (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ; Dunning, Alison M. (University of Cambridge) ; Oliver, Clare (University of Cambridge) ; Fineberg, Elena (University of Cambridge) ; Cook, Margaret (University of Cambridge) ; Peock, Susan (University of Cambridge) ; McCann, Emma (Glan Clwyd Hospital, Rhyl) ; Murray, Alex (Singleton Hospital, Swansea) ; Jacobs, Chris (Guy's and St. Thomas' National Health Service, London) ; Pichert, Gabriella (Guy's and St. Thomas' National Health Service, London) ; Lalloo, Fiona (Central Manchester University Hospitals National Health Service, Manchester) ; Chu, Carol (Yorkshire Regional Genetics Service, Leeds) ; Dorkins, Huw (Kennedy-Galton Centre, Harrow) ; Paterson, Joan (Addenbrookes Hospital (Cambridge, Regne Unit)) ; Ong, Kai-Ren (Birmingham Women's Hospital) ; Teixeira, Manuel R. (Universidade do Porto) ; Hogervorst, Frans B. L. (The Netherlands Cancer Institute (Amsterdam, Països Baixos)) ; van der Hout, Annemarie H. (University of Groningen) ; Seynaeve, Caroline (Erasmus University Medical Center, Rotterdam) ; van der Luijt, Rob B. (University Medical Center Utrecht, Utrecht) ; Ligtenberg, Marjolijn J. L. (Radboud university medical center, Nijmegen) ; Devilee, Peter (Leiden University Medical Center, Leiden) ; Wijnen, Juul T. (Leiden University Medical Center, Leiden) ; Rookus, Matti A. (The Netherlands Cancer Institute (Amsterdam, Països Baixos)) ; Meijers-Heijboer, Hanne E. J. (Vrije Universiteit, Amsterdam) ; Blok, Marinus J. (Maastricht University Medical Center) ; van den Ouweland, Ans M. W. (Erasmus University Medical Center, Rotterdam) ; Aalfs, Cora M. (Department of Clinical Genetics, Amsterdam) ; Rodriguez, Gustavo C. (University of Chicago) ; Phillips, Kelly-Anne A. (Peter MacCallum Cancer Centre, East Melbourne) ; Piedmonte, Marion (Roswell Park Cancer Institute, Buffalo, New York) ; Nerenstone, Stacy R. (Hartford Hospital/Helen and Harry Gray Cancer Center) ; Bae-Jump, Victoria L. (University of North Carolina) ; O'Malley, David M. (Ohio State University, Hilliard) ; Ratner, Elena S. (Yale University School of Medicine) ; Schmutzler, Rita K. (Uniklinik Köln (Colònia, Alemanya)) ; Wappenschmidt, Barbara (Uniklinik Köln (Colònia, Alemanya)) ; Rhiem, Kerstin (University Hospital of Cologne, Cologne, Germany) ; Engel, Christoph (University of Leipzig) ; Meindl, Alfons (Technical University Munich) ; Ditsch, Nina (Ludwig-Maximilian University Munich) ; Arnold, Norbert (Kiel University Medical Center Schleswig-Holstein) ; Plendl, Hansjoerg J. (Kiel University Medical Center Schleswig-Holstein) ; Niederacher, Dieter (University Hospital of Düsseldorf (Alemanya)) ; Sutter, Christian (Heidelberg University Hospital (Alemanya)) ; Wang-Gohrke, Shan (University Hospital of Ulm (Alemanya)) ; Steinemann, Doris (Institute of Cell and Molecular Pathology, Hannover) ; Preisler-Adams, Sabine (University of Münster) ; Kast, Karin (Technical University Dresden) ; Varon-Mateeva, Raymonda (Institute of Human Genetics, Campus Virchov Klinikum, Charite Berlin) ; Gehrig, Andrea (Centre of Familial Breast and Ovarian Cancer, Institute of Human Genetics, University Würzburg, Würzburg, Germany) ; Bojesen, Anders (Vejle Hospital, Vejle) ; Pedersen, Inge Sokilde (Aalborg University Hospital (Dinamarca)) ; Sunde, Lone (Aarhus University Hospital (Aarhus, Dinamarca)) ; Jensen, Uffe Birk (Aarhus University Hospital (Aarhus, Dinamarca)) ; Thomassen, Mads (Odense University Hospital (Dinamarca)) ; Kruse, Torben A. (Odense University Hospital (Dinamarca)) ; Foretova, Lenka (Masaryk Memorial Cancer Institute (Brno, República Txeca)) ; Peterlongo, Paolo (Fondazione Istituto di Oncologia MolecolarE, Milan) ; Bernard, Loris (Istituto Europeo di Oncologia, Milan) ; Peissel, Bernard (Fondazione Istituto Nazionale Tumori, Milan) ; Scuvera, Giulietta (Fondazione Istituto Nazionale Tumori, Milan) ; Manoukian, Siranoush (Fondazione Istituto Nazionale Tumori, Milan) ; Radice, Paolo (Fondazione Istituto Nazionale Tumori, Milan) ; Ottini, Laura ("Sapienza" University, Rome) ; Montagna, Marco (Istituto Oncologico Veneto, Padua) ; Agata, Simona (Istituto Oncologico Veneto, Padua) ; Maugard, Christine (Hopitaux Universitaire de Strasbourg) ; Simard, Jacques (Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec City) ; Soucy, Penny (Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec City) ; Berger, Andreas (Medical University of Vienna) ; Fink-Retter, Anneliese (Medical University of Vienna) ; Singer, Christian F. (Medical University of Vienna) ; Rappaport, Christine (Medical University of Vienna) ; Geschwantler-Kaulich, Daphne (Medical University of Vienna) ; Tea, Muy-Kheng (Medical University of Vienna) ; Pfeiler, Georg (Medical University of Vienna) ; John, Esther M. (Cancer Prevention Institute of California) ; Miron, Alex (Dana-Farber Cancer Institute, Boston, Massachusetts) ; Neuhausen, Susan L. (Beckman Research Institute of City of Hope (Duarte, Estats Units d'Amèrica)) ; Terry, Mary Beth (Columbia University) ; Chung, Wendy (Columbia University) ; Daly, Mary B. (Fox Chase Cancer Center, Philadelphia, Pennsylvania) ; Goldgar, David E. (University of Utah School of Medicine, Salt Lake City) ; Janavicius, Ramunas (Vilnius University Hospital Santariskiu Clinics) ; Dorfling, Cecilia M. (University of Pretoria, Arcadia) ; van Rensburg, Elisabeth J. (University of Pretoria, Arcadia) ; Fostira, Florentia (National Centre for Scientific Research Demokritos, Athens) ; Konstantopoulou, Irene (National Centre for Scientific Research Demokritos, Athens) ; Garber, Judy (Harvard Medical School, Boston) ; Godwin, Andrew K. (University of Kansas Medical Center, Kansas City) ; Olah, Edith (National Institute of Oncology, Budapest) ; Narod, Steven A. (University of Toronto) ; Rennert, Gad (Clalit National Israeli Cancer Control Center) ; Paluch, Shani Shimon (Chaim Sheba Medical Center, Ramat Gan) ; Laitman, Yael (Institute of Human Genetics, Ramat Gan) ; Friedman, Eitan (Tel Aviv University, Ramat Aviv) ; Liljegren, Annelie (Karolinska University Hospital and Karolinska Institutet (Suècia)) ; Rantala, Johanna (Karolinska University Hospital and Karolinska Institutet (Suècia)) ; Stenmark-Askmalm, Marie (Linköping University, Sweeden) ; Loman, Niklas (Lund University Hospital, Sweeden) ; Imyanitov, Evgeny N. (N.N. Petrov Institute of Oncology, St.-Petersburg) ; Hamann, Ute (German Cancer Research Center (DKFZ), Heidelberg) ; Spurdle, Amanda B. (Queensland Institute of Medical Research (QIMR) Berghofer Medical Research Institute, Brisbane) ; Healey, Sue (Queensland Institute of Medical Research (QIMR) Berghofer Medical Research Institute, Brisbane) ; Weitzel, Jeffrey N. (Clinical Cancer Genetics, City of Hope, Duarte, California) ; Herzog, Josef (Clinical Cancer Genetics, City of Hope, Duarte, California) ; Margileth, David (St. Joseph Hospital of Orange, Duarte, California) ; Gorrini, Chiara (University Health Network, Toronto) ; Esteller, M (Institució Catalana de Recerca i Estudis Avançats) ; Gómez Moruno, Antonio (Institut d'Investigació Biomèdica de Bellvitge) ; Sayols, Sergi (Institut d'Investigació Biomèdica de Bellvitge) ; Vidal, Enrique (Institut d'Investigació Biomèdica de Bellvitge) ; Heyn, Holger (Institut d'Investigació Biomèdica de Bellvitge) ; Stoppa-Lyonnet, Dominique (Université Paris Descartes, Sorbonne Paris Cité, Paris, France) ; Léoné, Melanie (Hospices Civils de Lyon-Centre Léon Bérard, Lyon) ; Barjhoux, Laure (Université Lyon 1) ; Fassy-Colcombet, Marion (Institut Curie, Paris) ; De Pauw, Antoine (Institut Curie, Paris) ; Lasset, Christine (Université Lyon 1) ; Ferrer, Sandra Fert (Hôtel Dieu Centre Hospitalier, Chambéry) ; Castera, Laurent (Department of Tumour Biology, Institut Curie, Paris) ; Berthet, Pascaline (Centre François Baclesse, Caen, France) ; Cornelis, François (Genetic Unit, Avicenne Hospital, Clermont-Ferrand) ; Bignon, Yves-Jean (Université de Clermont-Ferrand) ; Damiola, Francesca (Centre de Recherche en Cancérologie de Lyon) ; Mazoyer, Sylvie (Centre de Recherche en Cancérologie de Lyon) ; Sinilnikova, Olga M. (Centre de Recherche en Cancérologie de Lyon) ; Maxwell, Christopher A. (University of British Columbia, Vancouver) ; Vijai, Joseph (Memorial Sloan-Kettering Cancer Center, New York) ; Robson, Mark (Memorial Sloan-Kettering Cancer Center, New York) ; Kauff, Noah (Memorial Sloan-Kettering Cancer Center, New York) ; Corines, Marina (Memorial Sloan-Kettering Cancer Center, New York) ; Villano, Danylko (Memorial Sloan-Kettering Cancer Center, New York) ; Cunningham, Julie M. (Mayo Clinic, Rochester, Minnesota, United States of America) ; Lee, Adam (Mayo Clinic, Rochester, Minnesota) ; Lindor, Noralane (Mayo Clinic, Scottsdale, Arizona) ; Lázaro, Conxi (Institut d'Investigació Biomèdica de Bellvitge) ; Easton, Douglas F. (University of Cambridge) ; Offit, Kenneth (Memorial Sloan-Kettering Cancer Center, New York) ; Chenevix-Trench, Georgia (Queensland Institute of Medical Research, Brisbane, Australia) ; Couch, Fergus J. (Mayo Clinic, Rochester, Minnesota) ; Antoniou, Antonis C. (University of Cambridge) ; Pujana, Miguel Angel (Institut d'Investigació Biomèdica de Bellvitge)
While interplay between BRCA1 and AURKA-RHAMM-TPX2-TUBG1 regulates mammary epithelial polarization, common genetic variation in HMMR (gene product RHAMM) may be associated with risk of breast cancer in BRCA1 mutation carriers. [...]
2015 - 10.1371/journal.pone.0120020
PloS one, Vol. 10 (april 2015)  
3.
22 p, 1.6 MB Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus / Lawrenson, Kate (Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center) ; Kar, Siddhartha (Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; McCue, Karen (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia)) ; Kuchenbaeker, Karoline (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; Michailidou, Kyriaki (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; Tyrer, Jonathan (Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; Beesley, Jonathan (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia)) ; Ramus, Susan J. (Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center) ; Li, Qiyuan (Department of Medical Oncology, The Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute) ; Delgado, Melissa K. (Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center) ; Lee, Janet M. (Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center) ; Aittomäki, Kristiina (Helsinki University Hospital (Finlàndia)) ; Andrulis, Irene L. (Department of Molecular Genetics, University of Toronto) ; Anton-Culver, Hoda (Department of Epidemiology, Genetic Epidemiology Research Institute, School of Medicine, University of California Irvine) ; Arndt, Volker (Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)) ; Arun, Banu K. (University of Texas MD Anderson Cancer Center) ; Arver, Brita (Karolinska University Hospital and Karolinska Institutet (Suècia)) ; Bandera, Elisa V. (Cancer Prevention and Control, Rutgers Cancer Institute of New Jersey) ; Barile, Monica (Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia) ; Barkardottir, Rosa B. (Department of Pathology, Landspitali University Hospital and BMC (Biomedical Centre), Faculty of Medicine, University of Iceland) ; Barrowdale, Daniel (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; Beckmann, Matthias W. (University Hospital Erlangen, Department of Gynecology and Obstetrics, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN) ; Benitez, Javier (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Berchuck, Andrew (Department of Obstetrics and Gynecology, Duke University Medical Center) ; Bisogna, Maria (Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center) ; Bjorge, Line (Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen) ; Blomqvist, Carl (Helsinki University Hospital (Finlàndia)) ; Blot, William (International Epidemiology Institute) ; Bogdanova, Natalia (Gynaecology Research Unit, Hannover Medical School) ; Bojesen, Anders (Department of Clinical Genetics, Vejle Hospital) ; Bojesen, Stig E. (Copenhagen University Hospital) ; Bolla, Manjeet K. (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; Bonanni, Bernardo (Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia) ; Børresen-Dale, Anne-Lise (K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo) ; Brauch, Hiltrud (German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ)) ; Brennan, Paul (International Agency for Research on Cancer) ; Brenner, Hermann (Division of Preventive Oncology, German Cancer Research Center (DKFZ)) ; Bruinsma, Fiona (Cancer Epidemiology Centre (Melbourne, Austràlia)) ; Brunet, Joan (Institut d'Investigació Biomèdica de Girona) ; Buhari, Shaik Ahmad (Department of Surgery, National University Health System) ; Burwinkel, Barbara (Department of Obstetrics and Gynecology, University of Heidelberg) ; Butzow, Ralf (Department of Pathology, Helsinki University Central Hospital) ; Buys, Saundra (Department of Medicine, Huntsman Cancer Institute, University of Utah School of Medicine) ; Cai, Qiuyin (Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine) ; Caldes, Trinidad (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ; Campbell, Ian (Cancer Genetics Laboratory, Peter MacCallum Cancer Centre) ; Canniotto, Rikki (Cancer Pathology & Prevention, Division of Cancer Prevention and Population Sciences, Roswell Park Cancer Institute) ; Chang-Claude, Jenny (University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf) ; Chiquette, Jocelyne (Unité de recherche en santé des populations, Centre des maladies du sein Deschênes-Fabia, Centre de recherche FRSQ du Centre hospitalier affilié universitaire de Québec) ; Choi, Ji-Yeob (Department of Biomedical Sciences, Seoul National University College of Medicine) ; Claes, Kathleen (Center for Medical Genetics, Ghent University) ; Cook, Linda S. (Division of Epidemiology and Biostatistics, Department of Internal Medicine, University of New Mexico) ; Cox, Angela (Sheffield Cancer Research, Department of Oncology, University of Sheffield) ; Cramer, Daniel W. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ; Cross, Simon S. (Academic Unit of Pathology, Department of Neuroscience, University of Sheffield) ; Cybulski, Cezary (Department of Genetics and Pathology, Pomeranian Medical University) ; Czene, Kamila (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics) ; Daly, Mary B. (Department of Clinical Genetics, Fox Chase Cancer Center) ; Damiola, Francesca (INSERM U1052, CNRS UMR5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon) ; Dansonka-Mieszkowska, Agnieszka (Department of Pathology and Laboratory Diagnostics the Maria Sklodowska Curie Memorial Cancer Center and Institute of Oncology) ; Darabi, Hatef (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics) ; Dennis, Joe (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; Devilee, Peter (Department of Human Genetics, Leiden University Medical Center) ; Diez, Orland (Vall d'Hebron Institut d'Oncologia) ; Doherty, Jennifer A. (Department of Community and Family Medicine, Section of Biostatistics & Epidemiology, The Geisel School of Medicine at Dartmouth) ; Domchek, Susan M. (Department of Medicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania) ; Dorfling, Cecilia M. (Department of Genetics, University of Pretoria) ; Dörk, Thilo (Gynaecology Research Unit, Hannover Medical School) ; Dumont, Martine (Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University) ; Ehrencrona, Hans (Department of Clinical Genetics, Lund University Hospital) ; Ejlertsen, Bent (Copenhagen University Hospital Rigshospitalet) ; Ellis, Steve (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; Engel, Christoph (Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig) ; Lee, Eunjung (Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center) ; Evans, D. Gareth (Genomic Medicine, Manchester Academic Health Sciences Centre, Institute of Human Development, Manchester University, Central Manchester University Hospitals NHS Foundation Trust) ; Fasching, Peter A. (University of California at Los Angeles, David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology) ; Feliubadalo, Lidia (Institut d'Investigació Biomèdica de Bellvitge) ; Figueroa, Jonine (Division of Cancer Epidemiology and Genetics, National Cancer Institute) ; Flesch-Janys, Dieter (Department of Cancer Epidemiology, Clinical Cancer Registry, University Medical Center Hamburg-Eppendorf) ; Fletcher, Olivia (Division of Breast Cancer Research, The Institute of Cancer Research) ; Flyger, Henrik (Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital) ; Foretova, Lenka (Masaryk Memorial Cancer Institute and Medical Faculty MU) ; Fostira, Florentia (Molecular Diagnostics Laboratory, (INRASTES) Institute of Nuclear and Radiological Sciences and Technology, National Centre for Scientific Research 'Demokritos', Aghia Paraskevi Attikis) ; Foulkes, William D. (Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montreal) ; Fridley, Brooke L. (Biostatistics and Informatics Shared Resource, University of Kansas Medical Center) ; Friedman, Eitan (Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center) ; Frost, Debra (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; Gambino, Gaetana (University Hospital of Pisa (Pisa, Itàlia)) ; Ganz, Patricia A. (UCLA Schools of Medicine and Public Health, Division of Cancer Prevention & Control Research, Jonsson Comprehensive Cancer Center) ; Garber, Judy (Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute) ; García-Closas, Montserrat (Division of Genetics and Epidemiology, The Institute of Cancer Research) ; Gentry-Maharaj, Aleksandra (Women's Cancer, UCL EGA Institute for Women's Health) ; Ghoussaini, Maya (Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; Giles, Graham G. (Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne) ; Glasspool, Rosalind (Cancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre) ; Godwin, Andrew K. (Department of Pathology and Laboratory Medicine, University of Kansas Medical Center) ; Goldberg, Mark S. (Department of Medicine, McGill University) ; Goldgar, David E. (Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine) ; González-Neira, Anna (Centro Nacional de Investigaciones Oncológicas) ; Goode, Ellen L. (Department of Health Sciences Research, Mayo Clinic) ; Goodman, Marc T. (Cedars Sinai Heart Institute (Los Angeles, Estats Units d'Amèrica)) ; Greene, Mark H. (Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health) ; Gronwald, Jacek (Department of Genetics and Pathology, Pomeranian Medical University) ; Guénel, Pascal (University Paris-Sud) ; Haiman, Christopher A. (Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center) ; Hall, Per (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics) ; Hallberg, Emily (Department of Health Sciences Research, Mayo Clinic) ; Hamann, Ute (Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ)) ; Hansen, Thomas V. O. (Copenhagen University Hospital Rigshospitalet) ; Harrington, Patricia A. (Department of Oncology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory) ; Hartman, Mikael (Saw Swee Hock School of Public Health, National University of Singapore) ; Hassan, Norhashimah (Cancer Research Initiatives Foundation, Subang Jaya) ; Healey, Sue (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia)) ; Heitz, Florian (Department of Gynecology and Gynecologic Oncology, Dr Horst Schmidt Kliniken Wiesbaden) ; Herzog, Josef (Clinical Cancer Genetics, for the City of Hope Clinical Cancer Genetics Community Research Network) ; Høgdall, Estrid (Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center) ; Høgdall, Claus K. (Copenhagen University Hospital Rigshospitalet) ; Hogervorst, Frans B. L. (The Netherlands Cancer Institute (Amsterdam, Països Baixos)) ; Hollestelle, Antoinette (Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute) ; Hopper, John L. (Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne) ; Hulick, Peter J. (Center for Medical Genetics, NorthShore University Health System) ; Huzarski, Tomasz (Department of Genetics and Pathology, Pomeranian Medical University) ; Imyanitov, Evgeny N. (N.N. Petrov Institute of Oncology) ; Isaacs, Claudine (Lombardi Comprehensive Cancer Center, Georgetown University) ; Ito, Hidemi (Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute) ; Jakubowska, Anna (Department of Genetics and Pathology, Pomeranian Medical University) ; Janavicius, Ramunas (State Research Institute Centre for Innovative Medicine) ; Jensen, Allan (Copenhagen University Hospital Rigshospitalet) ; John, Esther M. (Department of Epidemiology, Cancer Prevention Institute of California) ; Johnson, Nichola (Division of Breast Cancer Research, The Institute of Cancer Research) ; Kabisch, Maria (Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ)) ; Kang, Daehee (Department of Preventive Medicine, Seoul National University College of Medicine) ; Kapuscinski, Miroslav (Centre for Epidemiology and Biostatistics, University of Melbourne) ; Karlan, Beth Y. (Cedars Sinai Heart Institute (Los Angeles, Estats Units d'Amèrica)) ; Khan, Sofia (Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital) ; Kiemeney, Lambertus A. (Radboud University Medical Centre, Radboud Institute for Health Sciences) ; Kjaer, Susanne Kruger (Copenhagen University Hospital Rigshospitalet) ; Knight, Julia A. (Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto) ; Konstantopoulou, Irene (Molecular Diagnostics Laboratory, (INRASTES) Institute of Nuclear and Radiological Sciences and Technology, National Centre for Scientific Research 'Demokritos', Aghia Paraskevi Attikis) ; Kosma, Veli-Matti (Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland) ; Kristensen, Vessela (Oslo University Hospital (Oslo, Noruega)) ; Kupryjanczyk, Jolanta (Department of Pathology and Laboratory Diagnostics the Maria Sklodowska Curie Memorial Cancer Center and Institute of Oncology) ; Kwong, Ava (Department of Surgery, The University of Hong Kong) ; De la Hoya, Miguel (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ; Laitman, Yael (Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center) ; Lambrechts, Diether (Laboratory for Translational Genetics, Department of Oncology, University of Leuven) ; Le, Nhu (Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center) ; De Leeneer, Kim (Center for Medical Genetics, Ghent University) ; Lester, Jenny (Cedars Sinai Heart Institute (Los Angeles, Estats Units d'Amèrica)) ; Levine, Douglas A. (Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center) ; Li, Jingmei (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics) ; Lindblom, Annika (Karolinska Institutet (Estocolm, Suècia). Department of Molecular Medicine and Surgery) ; Long, Jirong (Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine) ; Lophatananon, Artitaya (Division of Health Sciences, Warwick Medical School, Warwick University) ; Loud, Jennifer T. (Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health) ; Lu, Karen (Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center) ; Lubinski, Jan (Department of Genetics and Pathology, Pomeranian Medical University) ; Mannermaa, Arto (Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland) ; Manoukian, Siranoush (Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT)) ; Le Marchand, Loic (University of Hawaii Cancer Center) ; Margolin, Sara (Department of Oncology - Pathology, Karolinska Institutet) ; Marme, Frederik (National Center for Tumour Diseases, University of Heidelberg) ; Massuger, Leon F. A. G. (Radboud University Medical Centre. Department of Gynaecology) ; Matsuo, Keitaro (Department of Preventive Medicine, Kyushu University Faculty of Medical Sciences) ; Mazoyer, Sylvie (INSERM U1052, CNRS UMR5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon) ; McGuffog, Lesley (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; McLean, Catriona (Anatomical Pathology, The Alfred Hospital) ; McNeish, Iain (Institute of Cancer Sciences, University of Glasgow, Wolfson Wohl Cancer Research Centre, Beatson Institute for Cancer Research) ; Meindl, Alfons (Technische Universität München) ; Menon, Usha (Women's Cancer, UCL EGA Institute for Women's Health) ; Mensenkamp, Arjen R. (Department of Human Genetics, Radboud University Medical Centre) ; Milne, Roger L. (Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne) ; Montagna, Marco (Immunology and Molecular Oncology Unit, Instituto Oncologico Veneto IOV, IRCCS) ; Moysich, Kirsten B. (Department of Cancer Prevention and Control, Roswell Park Cancer Institute) ; Muir, Kenneth (Institute of Population Health, University of Manchester) ; Mulligan, Anna Marie (Department of Laboratory Medicine and Pathobiology, University of Toronto) ; Nathanson, Katherine L. (Department of Medicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania) ; Ness, Roberta B. (The University of Texas School of Public Health) ; Neuhausen, Susan L. (Department of Population Sciences, Beckman Research Institute of City of Hope) ; Nevanlinna, Heli (Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital) ; Nord, Silje (K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo) ; Nussbaum, Robert L. (Department of Medicine and Genetics, University of California) ; Odunsi, Kunle (Department of Gynecological Oncology, Roswell Park Cancer Institute) ; Offit, Kenneth (Department of Medicine, Memorial Sloan-Kettering Cancer Center) ; Olah, Edith (Department of Molecular Genetics, National Institute of Oncology) ; Olopade, Olufunmilayo I. (Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center) ; Olson, Janet E. (Department of Health Sciences Research, Mayo Clinic) ; Olswold, Curtis (Department of Health Sciences Research, Mayo Clinic) ; O'Malley, David (The Ohio State University and the James Cancer Center) ; Orlow, Irene (Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center) ; Orr, Nick (Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research) ; Osorio, Ana (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Park, Sue Kyung (Department of Surgery, Seoul National University College of Medicine) ; Pearce, Celeste L. (Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center) ; Pejovic, Tanja (Knight Cancer Institute, Oregon Health and Science University) ; Peterlongo, Paolo (IFOM, The FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology) ; Pfeiler, Georg (Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna) ; Phelan, Catherine M. (Department of Cancer Epidemiology, Moffitt Cancer Center) ; Poole, Elizabeth M. (Department of Epidemiology, Harvard TH Chan School of Public Health) ; Pylkäs, Katri (Laboratory of Cancer Genetics and Tumour Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu) ; Radice, Paolo (Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT)) ; Rantala, Johanna (Karolinska University Hospital and Karolinska Institutet (Suècia)) ; Rashid, Muhammad Usman (Department of Basic Sciences, Shaukat Khanum Memorial Cancer Hospital and Research Centre (SKMCH & RC)) ; Rennert, Gad (Clalit National Israeli Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine) ; Rhenius, Valerie (Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; Rhiem, Kerstin (University Hospital of Cologne (Colònia, Alemanya). Centre of Familial Breast and Ovarian Cancer and Centre for Integrated Oncology (CIO)) ; Risch, Harvey A. (Department of Chronic Disease Epidemiology, Yale School of Public Health) ; Rodriguez, Gus (Division of Gynecologic Oncology, NorthShore University HealthSystem) ; Rossing, Mary Anne (Department of Epidemiology, University of Washington) ; Rudolph, Anja (Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)) ; Salvesen, Helga B. (Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen) ; Sangrajrang, Suleeporn (National Cancer Institute) ; Sawyer, Elinor J. (King's College London) ; Schildkraut, Joellen M. (Cancer Control and Population Sciences, Duke Cancer Institute) ; Schmidt, Marjanka K. (Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital) ; Schmutzler, Rita K. (Center of Familial Breast and Ovarian Cancer, University Hospital of Cologne) ; Sellers, Thomas A. (Department of Cancer Epidemiology, Moffitt Cancer Center) ; Seynaeve, Caroline (Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute) ; Shah, Mitul (Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; Shen, Chen-Yang (School of Public Health, China Medical University) ; Shu, Xiao-Ou (Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine) ; Sieh, Weiva (Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine) ; Singer, Christian F. (Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna) ; Sinilnikova, Olga M. (INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon) ; Slager, Susan (Department of Health Sciences Research, Mayo Clinic) ; Song, Honglin (Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; Soucy, Penny (Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University) ; Southey, Melissa C. (Department of Pathology, University of Melbourne) ; Stenmark-Askmalm, Marie (Division of Clinical Genetics, Department of Clinical and Experimental Medicine, Linköping University) ; Stoppa-Lyonnet, Dominique (Université Paris Descartes) ; Sutter, Christian (Institute of Human Genetics, Department of Human Genetics, University Hospital Heidelberg) ; Swerdlow, Anthony (Division of Genetics and Epidemiology, The Institute of Cancer Research) ; Tchatchou, Sandrine (Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital) ; Teixeira, Manuel R. (Biomedical Sciences Institute (ICBAS), Porto University) ; Teo, Soo H. (Cancer Research Initiatives Foundation, Subang Jaya) ; Terry, Kathryn L. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ; Terry, Mary Beth (Department of Epidemiology, Mailman School of Public Health, Columbia University) ; Thomassen, Mads (Odense University Hospital (Dinamarca)) ; Tibiletti, Maria Grazia (UO Anatomia Patologica, Ospedale di Circolo-Università dell'Insubria) ; Tihomirova, Laima (Latvian Biomedical Research and Study Centre) ; Tognazzo, Silvia (Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV - IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico)) ; Toland, Amanda Ewart (Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University) ; Tomlinson, Ian (Wellcome Trust Centre for Human Genetics (Oxford, Regne Unit)) ; Torres, Diana (Institute of Human Genetics, Pontificia Universidad Javeriana, Cra. 7 #40-62) ; Truong, Thérèse (University Paris-Sud) ; Tseng, Chiu-chen (Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center) ; Tung, Nadine (Department of Medical Oncology, Beth Israel Deaconess Medical Center) ; Tworoger, Shelley S. (Department of Epidemiology, Harvard TH Chan School of Public Health) ; Vachon, Celine (Department of Health Sciences Research, Mayo Clinic) ; van den Ouweland, Ans M. W. (Department of Clinical Genetics, Erasmus University Medical Center) ; van Doorn, Helena C. (Department of Gynecology, Family Cancer Clinic, Erasmus MC Cancer Institute) ; van Rensburg, Elizabeth J. (Department of Genetics, University of Pretoria) ; Van't Veer, Laura J. (Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital) ; Vanderstichele, Adriaan (University Hospitals Leuven (Bèlgica)) ; Vergote, Ignace (University Hospitals Leuven (Bèlgica)) ; Vijai, Joseph (Department of Medicine, Memorial Sloan-Kettering Cancer Center) ; Wang, Qin (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; Wang-Gohrke, Shan (University Hospital Ulm, 89069 Ulm) ; Weitzel, Jeffrey N. (Clinical Cancer Genetics, for the City of Hope Clinical Cancer Genetics Community Research Network) ; Wentzensen, Nicolas (Division of Cancer Epidemiology and Genetics, National Cancer Institute) ; Whittemore, Alice S. (Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine) ; Wildiers, Hans (University Hospitals Leuven (Bèlgica)) ; Winqvist, Robert (Laboratory of Cancer Genetics and Tumour Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu) ; Wu, Anna H. (Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center) ; Yannoukakos, Drakoulis (Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research 'Demokritos') ; Yoon, Sook-Yee (University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya Medical Centre, University Malaya) ; Yu, Jyh-Cherng (Department of Surgery, Tri-Service General Hospital, National Defense Medical Center) ; Zheng, Wei (Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine) ; Zheng, Ying (Shanghai Center for Disease Control and Prevention) ; Khanna, Kum Kum (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia)) ; Simard, Jacques (Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University) ; Monteiro, Alvaro N. (Cancer Epidemiology Program, Division of Population Sciences, H. Lee Moffitt Cancer Center & Research Institute) ; French, Juliet D. (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia)) ; Couch, Fergus J. (Department of Laboratory Medicine and Pathology, Mayo Clinic) ; Freedman, Matthew L. (Department of Medical Oncology, The Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute) ; Easton, Douglas F. (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; Dunning, Alison M. (Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; Pharoah, Paul D. (Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; Edwards, Stacey L. (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia)) ; Chenevix-Trench, Georgia (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia)) ; Antoniou, Antonis C. (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; Gayther, Simon A. (Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center) ; Universitat Autònoma de Barcelona
A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P =9. [...]
2016 - 10.1038/ncomms12675
Nature communications, Vol. 7 (09 2016)  
4.
19 p, 1.8 MB Fine-Scale Mapping at 9p22.2 Identifies Candidate Causal Variants That Modify Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers / Vigorito, Elena (University of Cambridge. Centre for Cancer Genetic Epidemiology) ; Kuchenbaecker, Karoline B. (University of Cambridge. Centre for Cancer Genetic Epidemiology) ; Beesley, Jonathan (Department of Genetics, QIMR Berghofer Medical Research Institute, Herston Road, Brisbane, Australia, 4029) ; Adlard, Julian (Yorkshire Regional Genetics Service, Chapel Allerton Hospital, Leeds, United Kingdom) ; Agnarsson, Bjarni A. (Landspitali University Hospital (Reykjavík, Islàndia)) ; Andrulis, Irene L. (Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada) ; Arun, Banu K. (Department of Breast Medical Oncology and Clinical Cancer Genetics Program, University Of Texas MD Anderson Cancer Center, 1515 Pressler Street, CBP 5, Houston, TX, United States of America) ; Barjhoux, Laure (Bâtiment Cheney D, Centre Léon Bérard, 28 rue Laënnec, Lyon, France) ; Belotti, Muriel (Service de Génétique Oncologique, Institut Curie, 26, rue d'Ulm, Paris Cedex 05, France) ; Benitez, Javier (Centro Nacional de Investigaciones Oncológicas) ; Berger, Andreas (Dept of OB/GYN, Medical University of Vienna, Vienna, Austria) ; Bojesen, Anders (Department of Clinical Genetics, Vejle Hospital, Kabbeltoft 25, Vejle, Denmark) ; Bonanni, Bernardo (Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), via Ripamonti 435, 20141 Milan, Italy) ; Brewer, Carole (Royal Devon & Exeter Hospital (Exeter, Regne Unit)) ; Caldes, Trinidad (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ; Caligo, Maria (University Hospital of Pisa (Pisa, Itàlia)) ; Campbell, Ian (Research Division, Peter MacCallum Cancer Centre, Locked Bag 1, A'Beckett Street, Melbourne, VIC 8006, Australia) ; Chan, Salina B. (Divisadero Street, C415, San Francisco, CA 94143-1714, United States of America) ; Claes, Kathleen (Center for Medical Genetics, Ghent University, De Pintelaan 185, 9000 Gent, Belgium) ; Cohn, David E. (Ohio State University Columbus Cancer Council GYN Oncology, 3651 Ridge Mill Drive, Columbus, OH 43026, United States of America) ; Cook, Jackie (Sheffield Children's Hospital (Sheffield, Regne Unit)) ; Daly, Mary B. (Department of Clinical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA, United States of America) ; Damiola, Francesca (Bâtiment Cheney D, Centre Léon Bérard, 28 rue Laënnec, Lyon, France) ; Davidson, Rosemarie (Department of Clinical Genetics, South Glasgow University Hospitals, Glasgow, United Kingdom) ; De Pauw, Antoine (Service de Génétique Oncologique, Institut Curie, 26, rue d'Ulm, Paris Cedex 05, France) ; Delnatte, Capucine (Unité d'oncogénétique, ICO-Centre René Gauducheau, Boulevard Jacques Monod, 44805 Nantes Saint Herblain Cedex, France) ; Diez, Orland (Vall d'Hebron Institut d'Oncologia) ; Domchek, Susan M. (Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, United States of America) ; Dumont, Martine (Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, 2705 Laurier Boulevard, Quebec City (Quebec), Canada) ; Durda, Katarzyna (Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland) ; Dworniczak, Bernd (Institute of Human Genetics, University of Münster, Münster, Germany) ; Easton, Douglas F. (University of Cambridge. Centre for Cancer Genetic Epidemiology) ; Eccles, Diana M (University Hospital Southampton NHS Foundation Trust (Regne Unit)) ; Edwinsdotter Ardnor, Christina (Department of Radiation Sciences, Oncology, Umeå University, Umea, Sweden) ; Eeles, Ros (Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, United Kingdom) ; Ejlertsen, Bent (Copenhagen University Hospital Rigshospitalet) ; Ellis, Steve (Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, United Kingdom) ; Evans, D. Gareth (Genomic Medicine, Manchester Academic Health Sciences Centre, Institute of Human Development, Manchester University, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom) ; Feliubadalo, Lidia (Institut d'Investigació Biomèdica de Bellvitge) ; Fostira, Florentia (Molecular Diagnostics Laboratory, (INRASTES) Institute of Nuclear and Radiological Sciences and Technology, National Centre for Scientific Research "Demokritos", Patriarchou Gregoriou & Neapoleos str., Aghia Paraskevi, Attiki, Athens, Greece) ; Foulkes, William D. (Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montreal, Quebec, Canada) ; Friedman, Eitan (The Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, Ramat Gan 52621, and Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel) ; Frost, Debra (Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, United Kingdom) ; Gaddam, Pragna (Clinical Cancer Genetics Laboratory, Memorial Sloane Kettering Cancer Center, New York, NY, United States of America) ; Ganz, Patricia A. (UCLA Schools of Medicine and Public Health, Division of Cancer Prevention & Control Research, Jonsson Comprehensive Cancer Center, 650 Charles Young Drive South, Room A2-125 HS, Los Angeles, CA 90095-6900, United States of America) ; Garber, Judy (Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, United States of America) ; García-Barberán, Vanesa (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ; Gauthier-Villars, Marion (Service de Génétique Oncologique, Institut Curie, 26, rue d'Ulm, Paris Cedex 05, France) ; Gehrig, Andrea (Centre of Familial Breast and Ovarian Cancer, Department of Medical Genetics, Institute of Human Genetics, University Würzburg, Würzburg, Germany) ; Gerdes, Anne-Marie (Copenhagen University Hospital Rigshospitalet) ; Giraud, Sophie (Service de Génétique Moléculaire et Clinique, Hospices Civils de Lyon, Lyon cedex 04, France) ; Godwin, Andrew K. (Department of Pathology and Laboratory Medicine, 3901 Rainbow Boulevard, 4019 Wahl Hall East, MS 3040, University of Kansas Medical Center, Kansas City, Kansas, United States of America) ; Goldgar, David E. (Department of Dermatology, University of Utah School of Medicine, 30 North 1900 East, SOM 4B454, Salt Lake City, UT 84132, United States of America) ; Hake, Christopher R. (City of Hope Clinical Cancer Genetics Community Research Network, 1500 East Duarte Road, Duarte, CA 91010, United States of America) ; Hansen, Thomas V. O. (Copenhagen University Hospital Rigshospitalet) ; Healey, Sue (Department of Genetics, QIMR Berghofer Medical Research Institute, Herston Road, Brisbane, Australia, 4029) ; Hodgson, Shirley (Medical Genetics Unit, St George's, University of London, London, United Kingdom) ; Hogervorst, Frans B. L. (Family Cancer Clinic, Netherlands Cancer Institute, P.O. Box 90203, 1000 BE, Amsterdam, The Netherlands) ; Houdayer, Claude (Service de Génétique Oncologique, Institut Curie, 26, rue d'Ulm, Paris Cedex 05, France) ; Hulick, Peter J. (Center for Medical Genetics, NorthShore University Health System, University of Chicago Pritzker School of Medicine, 1000 Central Street, Suite 620, Evanston, IL 60201, United States of America) ; Imyanitov, Evgeny N. (N.N. Petrov Institute of Oncology, St.-Petersburg 197758, Russia) ; Isaacs, Claudine (Lombardi Comprehensive Cancer Center, Georgetown University, 3800 Reservoir Road NW, Washington, DC, United States of America) ; Izatt, Louise (Clinical Genetics, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom) ; Izquierdo, Angel (Institut d'Investigació Biomèdica de Girona) ; Jacobs, Lauren (Clinical Genetics Research Laboratory, Dept. of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, United States of America) ; Jakubowska, Anna (Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland) ; Janavicius, Ramunas (Vilnius University Hospital Santariskiu Clinics, Hematology, oncology and transfusion medicine center, Dept. of Molecular and Regenerative Medicine, Santariskiu st., State Research Institute Centre for Innovative medicine, Zygymantu st. 9, Vilnius, Lithuania) ; Jaworska-Bieniek, Katarzyna (Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland) ; Jensen, Uffe Birk (Aarhus University Hospital (Aarhus, Dinamarca)) ; John, Esther M. (Department of Epidemiology, Cancer Prevention Institute of California, 2201 Walnut Avenue, Suite 300, Fremont, CA 94538, United States of America) ; Vijai, Joseph (Clinical Genetics Research Laboratory, Dept. of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10044, United States of America) ; Karlan, Beth Y. (Cedars Sinai Heart Institute (Los Angeles, Estats Units d'Amèrica)) ; Kast, Karin (Department of Gynaecology and Obstetrics, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany) ; Investigators, KConFab (Kathleen Cuningham Consortium for Research into Familial Breast Cancer, Peter MacCallum Cancer Center, Melbourne, Australia) ; Khan, Sofia (Helsinki University Hospital (Finlàndia)) ; Kwong, Ava (The Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Center, Hong Kong Sanatorium and Hospital, Hong Kong China) ; Laitman, Yael (The Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, Ramat Gan 52621, Israel) ; Lester, Jenny (Cedars Sinai Heart Institute (Los Angeles, Estats Units d'Amèrica)) ; Lesueur, Fabienne (Genetic Epidemiology of Cancer team, Inserm U900, Institut Curie, Mines ParisTech, 26 rue d'Ulm, 75248 Paris cedex 05, France) ; Liljegren, Annelie (Karolinska University Hospital and Karolinska Institutet (Suècia)) ; Lubinski, Jan (Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland) ; Mai, Phuong L. (Clinical Genetics Branch, DCEG, NCI, NIH, 9609 Medical Center Drive, Room 6E-454, Bethesda, MD, United States of America) ; Manoukian, Siranoush (Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Via Giacomo Venezian 1, 20133 Milan, Italy) ; Mazoyer, Sylvie (Bâtiment Cheney D, Centre Léon Bérard, 28 rue Laënnec, Lyon, France) ; Meindl, Alfons (Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Munich, Germany) ; Mensenkamp, Arjen R. (Radboud University Medical Centre. Department of Human Genetics) ; Montagna, Marco (Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Via Gattamelata 64, Padua, Italy) ; Nathanson, Katherine L. (Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, United States of America) ; Neuhausen, Susan L. (Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, United States of America) ; Nevanlinna, Heli (Helsinki University Hospital (Finlàndia)) ; Niederacher, Dieter (University Hospital of Düsseldorf (Alemanya)) ; Olah, Edith (Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary) ; Olopade, Olufunmilayo I. (The University of Chicago Medicine, 5841 South Maryland Avenue, MC 2115 Chicago, IL 60637) ; Ong, Kai-ren (Birmingham Women's Hospital) ; Osorio, Ana (Centro Nacional de Investigaciones Oncológicas) ; Park, Sue Kyung (Department of Preventive Medicine, Seoul National University College of Medicine, Department of Biomedical Science, Seoul National University Graduate School, and Cancer Research Institute, Seoul National University, 103 Daehak-ro, Jongno-gu, Seoul 110-799, Korea) ; Paulsson-Karlsson, Ylva (Department of Immunology, Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden) ; Pedersen, Inge Sokilde (Aalborg University Hospital (Dinamarca)) ; Peissel, Bernard (Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Via Giacomo Venezian 1, 20133 Milan, Italy) ; Peterlongo, Paolo (IFOM, The FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, c/o IFOM-IEO campus, via Adamello 16, 20139 Milan, Italy) ; Pfeiler, Georg (Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria) ; Phelan, Catherine M. (Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, United States of America) ; Piedmonte, Marion (NRG Oncology, Statistics and Data Management Center, Roswell Park Cancer Institute, Elm St & Carlton St, Buffalo, NY 14263, United States of America) ; Poppe, Bruce (Center for Medical Genetics, Ghent University, De Pintelaan 185, 9000 Gent, Belgium) ; Pujana, Miquel Angel (Institut d'Investigació Biomèdica de Bellvitge) ; Radice, Paolo (Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predicted Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), c/o Amaedeolab, via GA Amadeo 42, 20133 Milan, Italy) ; Rennert, Gad (Clalit National Israeli Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, 7 Michal St., Haifa 34362, Israel) ; Rodriguez, Gustavo C. (Division of Gynecologic Oncology, NorthShore University HealthSystem, Univ of Chicago, 2650 Ridge Avenue Suite 1507 Walgreens, Evanston, IL 60201, United States of America) ; Rookus, Matti A. (The Netherlands Cancer Institute (Amsterdam, Països Baixos)) ; Ross, Eric A. (Biostatistics and Bioinformatics Facility, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, United States of America) ; Schmutzler, Rita Katharina (Center for Hereditary Breast and Ovarian Cancer, Medical Faculty, University Hospital Cologne, Cologne, Germany) ; Simard, Jacques (Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, 2705 Laurier Boulevard, Quebec City (Quebec), Canada) ; Singer, Christian F. (Dept of OB/GYN, Medical University of Vienna, Vienna, Austria, and Waehringer Guertel 18-20, A 1090 Vienna, Austria) ; Slavin, Thomas P. (Clinical Cancer Genetics, City of Hope, 1500 East Duarte Road, Duarte, California 91010, United States of America) ; Soucy, Penny (Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, 2705 Laurier Boulevard, Quebec City (Quebec), Canada) ; Southey, Melissa (Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, Victoria, Australia) ; Steinemann, Doris (Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany) ; Stoppa-Lyonnet, Dominique (Service de Génétique Oncologique, Institut Curie, 26, rue d'Ulm, Paris Cedex 05, France) ; Sukiennicki, Grzegorz (Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland) ; Sutter, Christian (Institute of Human Genetics, Department of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany) ; Szabo, Csilla I. (National Human Genome Research Institute, National Institutes of Health, Building 50, Room 5312, 50 South Drive, MSC 004, Bethesda, MD 20892-8004, United States of America) ; Tea, Muy-Kheng (Dept of OB/GYN, Medical University of Vienna, Vienna, Austria, and Waehringer Guertel 18-20, A 1090 Vienna, Austria) ; Teixeira, Manuel R. (Department of Genetics, Portuguese Oncology Institute, Rua Dr. António Bernardino de Almeida, 4200-072 Porto, Portugal) ; Teo, Soo-Hwang (Cancer Research Initiatives Foundation, Sime Darby Medical Centre, 1 Jalan SS12/1A, Subang Jaya, 47500 Malaysia) ; Terry, Mary Beth (Department of Epidemiology, Columbia University, New York, NY, United States of America) ; Thomassen, Mads (Odense University Hospital (Dinamarca)) ; Tibiletti, Maria Grazia (UO Anatomia Patologica, Ospedale di Circolo-Università dell'Insubria, Via O.Rossi 9, 21100 Varese, Italy) ; Tihomirova, Laima (Latvian Biomedical Research and Study Centre, Ratsupites str 1, Riga, Latvia) ; Tognazzo, Silvia (Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Via Gattamelata 64, Padua, Italy) ; van Rensburg, Elizabeth J. (Cancer Genetics Laboratory, Department of Genetics, University of Pretoria, Private Bag X323, Arcadia 0007, South Africa) ; Varesco, Liliana (Unit of Hereditary Cancer, Department of Epidemiology, Prevention and Special Functions, IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) AOU San Martino-IST Istituto Nazionale per la Ricerca sul Cancro, largo Rosanna Benzi 10, 16132 Genoa, Italy) ; Varon-Mateeva, Raymonda (Institute of Human Genetics, Campus Virchov Klinikum, Charite Berlin, Berlin, Germany) ; Vratimos, Athanassios (Molecular Diagnostics Laboratory, (INRASTES) Institute of Nuclear and Radiological Sciences and Technology, National Centre for Scientific Research "Demokritos" Patriarchou Gregoriou & Neapoleos str., Aghia Paraskevi, Attiki, Athens, Greece) ; Weitzel, Jeffrey N. (Clinical Cancer Genetics, City of Hope, 1500 East Duarte Road, Duarte, California 91010, United States of America) ; McGuffog, Lesley (University of Cambridge. Centre for Cancer Genetic Epidemiology) ; Kirk, Judy (Westmead Hospital) ; Toland, Amanda Ewart (Divison of Human Cancer Genetics, Departments of Internal Medicine and Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, 998 Biomedical Research Tower, Columbus, OH, United States of America) ; Hamann, Ute (Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120 Heidelberg, Germany) ; Lindor, Noralane (Department of Health Sciences Research, Mayo Clinic, 13400 E. Scottsdale Blvd., Scottsdale, AZ, United States of America) ; Ramus, Susan J. (Department of Preventive Medicine, Keck School of Medicine, University of Southern California, California, United States of America) ; Greene, Mark H. (Clinical Genetics Branch, DCEG, NCI, NIH, 9609 Medical Center Drive, Room 6E-454, Bethesda, MD, United States of America) ; Couch, Fergus J. (Department of Laboratory Medicine and Pathology, and Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, Minnesota, United States of America) ; Offit, Kenneth (Clinical Genetics Research Laboratory, Dept. of Medicine, Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10044, United States of America) ; Pharoah, Paul D. P. (Department of Oncology, University of Cambridge, Cambridge, United Kingdom) ; Chenevix-Trench, Georgia (Department of Genetics, QIMR Berghofer Medical Research Institute, Herston Road, Brisbane, Australia, 4029) ; Antoniou, Antonis C. (University of Cambridge. Centre for Cancer Genetic Epidemiology) ; Universitat Autònoma de Barcelona
Population-based genome wide association studies have identified a locus at 9p22. 2 associated with ovarian cancer risk, which also modifies ovarian cancer risk in BRCA1 and BRCA2 mutation carriers. We conducted fine-scale mapping at 9p22. [...]
2016 - 10.1371/journal.pone.0158801
PloS one, Vol. 11 (july 2016)  
5.
13 p, 1009.7 KB Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer / Couch, Fergus J. (Mayo Clinic) ; Kuchenbaecker, Karoline B. (University of Cambridge) ; Michailidou, Kyriaki (University of Cambridge) ; Mendoza-Fandino, Gustavo A. (H. Lee Moffitt Cancer Center and Research Institute) ; Nord, Silje (Oslo University Hospital (Oslo, Noruega)) ; Lilyquist, Janna (Mayo Clinic) ; Olswold, Curtis (Mayo Clinic) ; Hallberg, Emily (Mayo Clinic) ; Agata, Simona (Istituto Oncologico Veneto IOV-IRCCS) ; Ahsan, Habibul (The University of Chicago) ; Aittomäki, Kristiina (Helsinki University Central Hospital) ; Ambrosone, Christine B (Roswell Park Cancer Institute) ; Andrulis, Irene L. (University of Toronto) ; Anton-Culver, Hoda (University of California Irvine) ; Arndt, Volker (German Cancer Research Center) ; Arun, Banu K. (University of Texas MD Anderson Cancer Center) ; Arver, Brita (Karolinska University Hospital and Karolinska Institutet (Suècia)) ; Barile, Monica (Istituto Europeo di Oncologia) ; Barkardottir, Rosa B. (Landspitali University Hospital (Islàndia)) ; Barrowdale, Daniel (University of Cambridge) ; Beckmann, Lars (Institute for Quality and Efficiency in Health Care) ; Beckmann, Matthias W. (University Breast Center Franconia) ; Benitez, Javier (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Blank, Stephanie V. (New York University School of Medicine) ; Blomqvist, Carl (University of Helsinki and Helsinki University Central Hospital) ; Bogdanova, Natalia V. (Hannover Medical School) ; Bojesen, Stig E. (Copenhagen University Hospital) ; Bolla, Manjeet K. (University of Cambridge) ; Bonanni, Bernardo (Istituto Europeo di Oncologia) ; Brauch, Hiltrud (University of Tübingen) ; Brenner, Hermann (German Cancer Research Center and National Center for Tumor Diseases) ; Burwinkel, Barbara (University of Heidelberg) ; Buys, Saundra (University of Utah School of Medicine) ; Caldes, Trinidad (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ; Caligo, Maria (University Hospital of Pisa (Pisa, Itàlia)) ; Canzian, Federico (German Cancer Research Center) ; Carpenter, Jane (University of Sydney) ; Chang-Claude, Jenny (German Cancer Research Center) ; Chanock, Stephen (Centro Nacional de Investigaciones Oncológicas) ; Chung, Wendy (Columbia University) ; Claes, Kathleen (Ghent University) ; Cox, Angela (University of Sheffield) ; Cross, Simon S. (University of Sheffield) ; Cunningham, Julie M. (Mayo Clinic) ; Czene, Kamila (Karolinska Institutet (Estocolm, Suècia)) ; Daly, Mary B. (Fox Chase Cancer Center) ; Damiola, Francesca (Université Lyon) ; Darabi, Hatef (Karolinska Institutet (Estocolm, Suècia)) ; De la Hoya, Miguel (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ; Devilee, Peter (Leiden University Medical Center) ; Diez, Orland (Vall d'Hebron Institut d'Oncologia) ; Ding, Yuan C. (Beckman Research Institute of City of Hope (Duarte, Estats Units d'Amèrica)) ; Dolcetti, Riccardo (CRO Aviano National Cancer Institute) ; Domchek, Susan M. (University of Pennsylvania) ; Dorfling, Cecilia M. (University of Pretoria) ; dos-Santos-Silva, Isabel (London School of Hygiene and Tropical Medicine) ; Dumont, Martine (Laval University) ; Dunning, Alison M. (University of Cambridge) ; Eccles, Diana M. (University Hospital Southampton NHS Foundation Trust (Regne Unit)) ; Ehrencrona, Hans (Lund University Hospital) ; Ekici, Arif B. (Comprehensive Cancer Center -EMN) ; Eliassen, Heather (Harvard School of Public Health) ; Ellis, Steve (University of Cambridge) ; Fasching, Peter A. (University Breast Center Franconia) ; Figueroa, Jonine (National Cancer Institute) ; Flesch-Janys, Dieter (University Clinic Hamburg-Eppendorf) ; Försti, Asta (Lund University) ; Fostira, Florentia (Memokritos', Aghia Paraskevi Attikis) ; Foulkes, William D. (McGill University) ; Friebel, Tara (University of) ; Friedman, Eitan (Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center) ; Frost, Debra (Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge) ; Gabrielson, Marike (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics) ; Gammon, Marilie D. (Department of Epidemiology, University of) ; Ganz, Patricia A. (UCLA Schools of Medicine and Public Health, Division of Cancer Prevention and Control Research, Jonsson Comprehensive Cancer Center) ; Gapstur, Susan M. (Epidemiology Research Program, American Cancer Society) ; Garber, Judy (Cancer Risk and Prevention Clinic, Dana Farber Cancer Institute) ; Gaudet, Mia M. (Epidemiology Research Program, American Cancer Society) ; Gayther, Simon A. (Department of Biomedical Sciences, Cedars Sinai Medical Center) ; Gerdes, Anne-Marie (Copenhagen University Hospital Rigshospitalet) ; Ghoussaini, Maya (University of Cambridge) ; Giles, Graham G. (Cancer Council Victoria) ; Glendon, Gord (Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital) ; Godwin, Andrew K. (University of Kansas Medical Center) ; Goldberg, Mark S. (Royal Victoria Hospital) ; Goldgar, David E. (University of Utah School of Medicine) ; González-Neira, Anna (Centro Nacional de Investigaciones Oncológicas) ; Greene, Mark H. (Clinical Genetics Branch) ; Gronwald, Jacek (Pomeranian Medical University) ; Guénel, Pascal (Inserm (National Institute of Health and Medical Research)) ; Gunter, Marc (Imperial College London) ; Haeberle, Lothar (University Breast Center Franconia) ; Haiman, Christopher A. (Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center) ; Hamann, Ute (Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ)) ; Hansen, Thomas V. O. (Copenhagen University Hospital Rigshospitalet) ; Hart, Steven (Department of Health Sciences Research, Mayo Clinic) ; Healey, Sue (Department of Genetics, QIMR Berghofer Medical Research Institute) ; Heikkinen, Tuomas (Helsinki University Central Hospital) ; Henderson, Brian E. (Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center) ; Herzog, Josef (Clinical Cancer Genetics, for the City of Hope Clinical Cancer Genetics Community Research Network) ; Hogervorst, Frans B. L. (The Netherlands Cancer Institute (Amsterdam, Països Baixos)) ; Hollestelle, Antoinette (Department of Medical Oncology, Erasmus MC Cancer Institute) ; Hooning, Maartje J. (Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center) ; Hoover, Robert (Division of Cancer Epidemiology and Genetics, National Cancer Institute) ; Hopper, John L. (Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne) ; Humphreys, Keith (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics) ; Hunter, David J. (Program in Molecular and Genetic Epidemiology, Harvard School of Public Health) ; Huzarski, Tomasz (Department of Genetics and Pathology, Pomeranian Medical University) ; Imyanitov, Evgeny N. (N.N. Petrov Institute of Oncology) ; Isaacs, Claudine (Lombardi Comprehensive Cancer Center, Georgetown University) ; Jakubowska, Anna (Department of Genetics and Pathology, Pomeranian Medical University) ; James, Paul (Department of Oncology, The University of Melbourne) ; Janavicius, Ramunas (State Research Institute Centre for Innovative Medicine) ; Jensen, Uffe Birk (Aarhus University Hospital (Aarhus, Dinamarca)) ; John, Esther M. (Department of Epidemiology, Cancer Prevention Institute of California) ; Jones, Michael (Division of Genetics and Epidemiology, Institute of Cancer Research) ; Kabisch, Maria (Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ)) ; Kar, Siddhartha (Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge) ; Karlan, Beth Y. (Cedars Sinai Heart Institute (Los Angeles, Estats Units d'Amèrica)) ; Khan, Sofia (Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital) ; Khaw, Kay-Tee (Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory) ; Kibriya, Muhammad G. (Department of Health Studies, The University of Chicago) ; Knight, Julia A. (Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital) ; Ko, Yon-Dschun (Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus) ; Konstantopoulou, Irene (Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos', Aghia Paraskevi Attikis) ; Kosma, Veli-Matti (School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland) ; Kristensen, Vessela (Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet) ; Kwong, Ava (Department of Surgery, The University of Hong Kong) ; Laitman, Yael (Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center) ; Lambrechts, Diether (Vesalius Research Center, VIB) ; Lazaro, Conxi (Institut Català d'Oncologia) ; Lee, Eunjung (Department of Preventive Medicine, University of Southern California) ; Le Marchand, Loic (Cancer Epidemiology Program, University of Cancer Center) ; Lester, Jenny (Cedars Sinai Heart Institute (Los Angeles, Estats Units d'Amèrica)) ; Lindblom, Annika (Karolinska Institutet (Estocolm, Suècia). Department of Molecular Medicine and Surgery) ; Lindor, Noralane (Health Sciences Research, Mayo Clinic) ; Lindstrom, Sara (Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health) ; Liu, Jianjun (Human Genetics Division, Genome Institute of Singapore) ; Long, Jirong (Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine) ; Lubinski, Jan (Department of Genetics and Pathology, Pomeranian Medical University) ; Mai, Phuong L. (Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health) ; Makalic, Enes (Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne) ; Malone, Kathleen E. (Department of Epidemiology, School of Public Health and Community Medicine, University of Washington) ; Mannermaa, Arto (School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland) ; Manoukian, Siranoush (Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT)) ; Margolin, Sara (Karolinska University Hospital and Karolinska Institutet (Suècia)) ; Marme, Frederik (Department of Obstetrics and Gynecology, University of Heidelberg) ; Martens, John W. M. (Department of Medical Oncology, Erasmus MC Cancer Institute) ; McGuffog, Lesley (Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge) ; Meindl, Alfons (Department of Gynaecology and Obstetrics, Technical University of Munich) ; Miller, Austin (NRG Oncology Statistics and Data Management Center, Roswell Park Cancer Institute) ; Milne, Roger L. (Cancer Epidemiology Centre (Melbourne, Austràlia)) ; Miron, Penelope (Department of Genomics and Genome Sciences, Case Western Reserve University Medical School) ; Montagna, Marco (Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV-IRCCS) ; Mazoyer, Sylvie (INSERM U1052, CNRS UMR5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon) ; Mulligan, Anna M. (Department of Laboratory Medicine and Pathobiology, University of Toronto) ; Muranen, Taru A. (Helsinki University Central Hospital) ; Nathanson, Katherine L. (Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania) ; Neuhausen, Susan L. (Department of Population Sciences, Beckman Research Institute of City of Hope) ; Nevanlinna, Heli (Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital) ; Nordestgaard, Børge G. (Copenhagen University Hospital) ; Nussbaum, Robert L. (Invitae Corporation) ; Offit, Kenneth (Department of Medicine, Memorial Sloan-Kettering Cancer Center) ; Olah, Edith (Department of Molecular Genetics, National Institute of Oncology) ; Olopade, Olufunmilayo I. (Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center) ; Olson, Janet E. (Department of Health Sciences Research, Mayo Clinic) ; Osorio, Ana (Centro Nacional de Investigaciones Oncológicas) ; Park, Sue K. (Department of Preventive Medicine and Biomedical Science, Seoul National University College of Medicine and Cancer Research Institute, Seoul National University) ; Peeters, Petra H. (MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London) ; Peissel, Bernard (Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT)) ; Peterlongo, Paolo (IFOM, Fondazione Istituto FIRC di Oncologia Molecolare) ; Peto, Julian (Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine) ; Phelan, Catherine M. (Cancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute) ; Pilarski, Robert (Divison of Human Genetics, Department of Internal Medicine, The Comprehensive Cancer Center, The Ohio State University) ; Poppe, Bruce (Center for Medical Genetics, Ghent University) ; Pylkäs, Katri (Oulu University Hospital (Finlàndia)) ; Radice, Paolo (Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT)) ; Rahman, Nazneen (Section of Cancer Genetics, Institute of Cancer Research) ; Rantala, Johanna (Karolinska University Hospital and Karolinska Institutet (Suècia)) ; Rappaport, Christine (Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna) ; Rennert, Gad (Clalit National Israeli Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine) ; Richardson, Andrea (Department of Pathology, Johns Hopkins University School of Medicine) ; Robson, Mark (Department of Medicine, Memorial Sloan-Kettering Cancer Center) ; Romieu, Isabelle (International Agency for Research on Cancer) ; Rudolph, Anja (Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)) ; Rutgers, Emiel J. (Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital) ; Sanchez, Maria-Jose (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ; Santella, Regina M. (Department of Environmental Health Sciences, Columbia University) ; Sawyer, Elinor J. (Research Oncology, Division of Cancer Studies, King's College London, Guy's Hospital) ; Schmidt, Daniel F. (Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne) ; Schmidt, Marjanka K. (Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital) ; Schmutzler, Rita K. (Center for Molecular Medicine Cologne (CMMC), University of Cologne) ; Schumacher, Fredrick (Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center) ; Scott, Rodney (Division of Genetics, Hunter Area Pathology Service, John Hunter Hospital) ; Senter, Leigha (Divison of Human Genetics, Department of Internal Medicine, The Comprehensive Cancer Center, The Ohio State University) ; Sharma, Priyanka (Department of Hematology and Oncology, University of Kansas Medical Center) ; Simard, Jacques (Centre Hospitalier Universitaire de Québec Research Center, Laval University) ; Singer, Christian F. (Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna) ; Sinilnikova, Olga M. (Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon-Centre Léon Bérard) ; Soucy, Penny (Centre Hospitalier Universitaire de Québec Research Center, Laval University) ; Southey, Melissa (Department of Pathology, The University of Melbourne) ; Steinemann, Doris (Hannover Medical School) ; Stenmark-Askmalm, Marie (Division of Clinical Genetics, Department of Clinical and Experimental Medicine, Linköping University) ; Stoppa-Lyonnet, Dominique (Université Paris Descartes) ; Swerdlow, Anthony (Division of Genetics and Epidemiology, Institute of Cancer Research) ; Szabo, Csilla I. (National Human Genome Research Institute, National Institutes of Health) ; Tamimi, Rulla (Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health) ; Tapper, William (University Hospital Southampton NHS Foundation Trust (Regne Unit)) ; Teixeira, Manuel R. (Biomedical Sciences Institute (ICBAS), Porto University) ; Teo, Soo-Hwang (University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya Medical Centre, University Malaya) ; Terry, Mary Beth (Department of Epidemiology, Mailman School of Public Health, Columbia University) ; Thomassen, Mads (Odense University Hospital (Dinamarca)) ; Thompson, Deborah (Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge) ; Tihomirova, Laima (Latvian Biomedical Research and Study Centre) ; Toland, Amanda E. (Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University) ; Tollenaar, Robert A. E. M. (Department of Surgical Oncology, Leiden University Medical Center) ; Tomlinson, Ian (Wellcome Trust Centre for Human Genetics (Oxford, Regne Unit)) ; Truong, Thérèse (Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer) ; Tsimiklis, Helen (Department of Pathology, The University of Melbourne) ; Teulé, Alex (Institut d'Investigació Biomèdica de Bellvitge) ; Tumino, Rosario (Cancer Registry and Histopathology Unit, 'Civic-M.P. Arezzo' Hospital) ; Tung, Nadine (Department of Medical Oncology, Beth Israel Deaconess Medical Center) ; Turnbull, Clare (Section of Cancer Genetics, Institute of Cancer Research) ; Ursin, Giski (Cancer Registry of Norway, Institute of Population-Based Cancer Research) ; van Deurzen, Carolien H. M. (Department of Pathology, Family Cancer Clinic, Erasmus University Medical Center) ; van Rensburg, Elizabeth J. (Department of Genetics, University of Pretoria) ; Varon-Mateeva, Raymonda (Institute of Human Genetics, Charite Berlin) ; Wang, Zhaoming (Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute) ; Wang-Gohrke, Shan (University Hospital of Ulm (Alemanya)) ; Weiderpass, Elisabete (Genetic Epidemiology Group, Folkhälsan Research Center) ; Weitzel, Jeffrey N. (Clinical Cancer Genetics, for the City of Hope Clinical Cancer Genetics Community Research Network) ; Whittemore, Alice (Department of Health Research and Policy-Epidemiology, Stanford University School of Medicine) ; Wildiers, Hans (Multidisciplinary Breast Center, Department of General Medical Oncology, University Hospitals) ; Winqvist, Robert (Oulu University Hospital (Finlàndia)) ; Yang, Xiaohong R. (Division of Cancer Epidemiology and Genetics, National Cancer Institute) ; Yannoukakos, Drakoulis (Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos', Aghia Paraskevi Attikis) ; Yao, Song (Department of Cancer Prevention and Control, Roswell Park Cancer Institute) ; Zamora, M. Pilar (Hospital Universitario La Paz (Madrid)) ; Zheng, Wei (Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine) ; Hall, Per (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics) ; Kraft, Peter (Department of Biostatistics, Harvard School Of Public Health) ; Vachon, Celine (Department of Health Sciences Research, Mayo Clinic) ; Slager, Susan (Department of Health Sciences Research, Mayo Clinic) ; Chenevix-Trench, Georgia (Cancer Division, QIMR Berghofer Medical Research Institute) ; Pharoah, Paul D. P. (Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge) ; Monteiro, Alvaro A. N. (Cancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute) ; García-Closas, Montserrat (Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health) ; Easton, Douglas F. (Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge) ; Antoniou, Antonis C. (Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge) ; Universitat Autònoma de Barcelona
Common variants in 94 loci have been associated with breast cancer including 15 loci with genome-wide significant associations (P <5 × 10 −8) with oestrogen receptor (ER)-negative breast cancer and BRCA1 -associated breast cancer risk. [...]
2016 - 10.1038/ncomms11375
Nature communications, Vol. 7 (04 2016)  
6.
13 p, 765.7 KB Male breast cancer in BRCA1 and BRCA2 mutation carriers : pathology data from the Consortium of Investigators of Modifiers of BRCA1/2 / Silvestri, Valentina (Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena, 324, 00161 Rome, Italy) ; Barrowdale, Daniel (University of Cambridge. Centre for Cancer Genetic Epidemiology) ; Mulligan, Anna Marie (Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON Canada) ; Neuhausen, Susan L. (Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA USA) ; Fox, Stephen (Peter MacCallum Cancer Institute, East Melbourne, Australia) ; Karlan, Beth Y. (Cedars Sinai Heart Institute (Los Angeles, Estats Units d'Amèrica)) ; Mitchell, Gillian (Department of Oncology, The University of Melbourne, Melbourne, VIC Australia) ; James, Paul (Department of Oncology, The University of Melbourne, Melbourne, VIC Australia) ; Thull, Darcy L. (University of Pittsburgh School of Medicine, Pittsburgh, PA USA) ; Zorn, Kristin K. (University of Pittsburgh School of Medicine, Pittsburgh, PA USA) ; Carter, Natalie J. (UPMC Cancer Center, Pittsburgh, PA USA) ; Nathanson, Katherine L. (Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA USA) ; Domchek, Susan M. (Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA USA) ; Rebbeck, Timothy R. (Department of Epidemiology and Biostatistics, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA) ; Ramus, Susan J. (Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA USA) ; Nussbaum, Robert L. (Department of Medicine and Genetics, University of California, San Francisco, San Francisco, CA USA) ; Olopade, Olufunmilayo I. (Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center, Chicago, IL USA) ; Rantala, Johanna (Karolinska University Hospital and Karolinska Institutet (Suècia)) ; Yoon, Sook-Yee (University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia) ; Caligo, Maria (University Hospital of Pisa (Pisa, Itàlia)) ; Spugnesi, Laura (University Hospital of Pisa (Pisa, Itàlia)) ; Bojesen, Anders (Department of Clinical Genetics, Vejle Hospital, Vejle, Denmark) ; Pedersen, Inge Sokilde (Aalborg University Hospital (Dinamarca)) ; Thomassen, Mads (Odense University Hospital (Dinamarca)) ; Jensen, Uffe Birk (Aarhus University Hospital (Aarhus, Dinamarca)) ; Toland, Amanda Ewart (Department of Molecular Virology, Immunology and Medical Genetics, College of Medicine, The Ohio State University, Columbus, OH USA) ; Senter, Leigha (Division of Human Genetics, Department of Internal Medicine, The Comprehensive Cancer Center, The Ohio State University, Columbus, OH USA) ; Andrulis, Irene L. (Department of Molecular Genetics, University of Toronto, Toronto, ON Canada) ; Glendon, Gord (Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON Canada) ; Hulick, Peter J. (Center for Medical Genetics, North Shore University Health System, Evanston, IL USA) ; Imyanitov, Evgeny N. (N.N. Petrov Institute of Oncology, St. Petersburg, Russia) ; Greene, Mark H. (Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD USA) ; Mai, Phuong L. (Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD USA) ; Singer, Christian F. (Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria) ; Rappaport-Fuerhauser, Christine (Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria) ; Kramer, Gero (Department of Urology, Medical University of Vienna, Vienna, Austria) ; Vijai, Joseph (Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY USA) ; Offit, Kenneth (Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY USA) ; Robson, Mark (Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY USA) ; Lincoln, Anne (Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY USA) ; Jacobs, Lauren (Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY USA) ; Machackova, Eva (Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic) ; Foretova, Lenka (Masaryk Memorial Cancer Institute and Faculty of Medicine, Masaryk University, Brno, Czech Republic) ; Navratilova, Marie (Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic) ; Vasickova, Petra (Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic) ; Couch, Fergus J. (Department of Health Sciences Research, Mayo Clinic, Rochester, MN USA) ; Hallberg, Emily (Department of Health Sciences Research, Mayo Clinic, Rochester, MN USA) ; Ruddy, Kathryn J. (Department of Oncology, Mayo Clinic, Rochester, MN USA) ; Sharma, Priyanka (Department of Hematology and Oncology, University of Kansas Medical Center, Kansas City, KS USA) ; Kim, Sung-Won (Department of Surgery, Daerim St. Mary's Hospital, Seoul, Korea) ; Teixeira, Manuel R. (Biomedical Sciences Institute (ICBAS), University of Porto, Porto, Portugal) ; Pinto, Pedro (Department of Genetics, Portuguese Institute of Oncology, Porto, Portugal) ; Montagna, Marco (Istituto di Ricovero e Cura A Carattere Scientifico (IRCCS)) ; Matricardi, Laura (Istituto di Ricovero e Cura A Carattere Scientifico (IRCCS)) ; Arason, Adalgeir (Department of Pathology, Landspitali University Hospital and Biomedical Centre (BMC), Faculty of Medicine, University of Iceland, Reykjavik, Iceland) ; Johannsson, Oskar Th (Landspitali University Hospital (Reykjavík, Islàndia)) ; Barkardottir, Rosa B. (Department of Pathology, Landspitali University Hospital and Biomedical Centre (BMC), Faculty of Medicine, University of Iceland, Reykjavik, Iceland) ; Jakubowska, Anna (Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland) ; Lubinski, Jan (Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland) ; Izquierdo, Angel (Institut Català d'Oncologia) ; Pujana, Miguel Angel (Institut d'Investigació Biomèdica de Bellvitge) ; Balmaña Gelpí, Judith (Vall d'Hebron Institut d'Oncologia) ; Diez, Orland (Vall d'Hebron Institut d'Oncologia) ; Ivady, Gabriella (Department of Pathology, National Institute of Oncology, Budapest, Hungary) ; Papp, Janos (Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary) ; Olah, Edith (Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary) ; Kwong, Ava (Department of Surgery, The University of Hong Kong, Hong Kong, China) ; Nevanlinna, Heli (Helsinki University Hospital (Finlàndia)) ; Aittomäki, Kristiina (Helsinki University Hospital (Finlàndia)) ; Pérez-Segura, Pedro (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ; Caldes, Trinidad (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ; Van Maerken, Tom (Center for Medical Genetics, Ghent University, Ghent, Belgium) ; Poppe, Bruce (Center for Medical Genetics, Ghent University, Ghent, Belgium) ; Claes, Kathleen (Center for Medical Genetics, Ghent University, Ghent, Belgium) ; Isaacs, Claudine (Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA) ; Elan, Camille (Department of Tumour Biology, Institut Curie, Paris, France) ; Lasset, Christine (Unité de Prévention et d'Epidémiologie Génétique, Centre Léon Bérard, Lyon, France) ; Stoppa-Lyonnet, Dominique (Université Paris Descartes, Sorbonne Paris Cité, Paris, France) ; Barjhoux, Laure (INSERM U1052, CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, Université Lyon, Lyon, France) ; Belotti, Muriel (Department of Tumour Biology, Institut Curie, Paris, France) ; Meindl, Alfons (Department of Gynaecology and Obstetrics, Technical University of Munich, Munich, Germany) ; Gehrig, Andrea (Institute of Human Genetics, University of Wurzburg, Wurzburg, Germany) ; Sutter, Christian (Institute of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany) ; Engel, Christoph (Institute for Medical Informatics, Statistics and Epidemiology University of Leipzig, Leipzig, Germany) ; Niederacher, Dieter (University of Dusseldorf, Dusseldorf, Germany) ; Steinemann, Doris (Hannover Medical School, Hannover, Germany) ; Hahnen, Eric (Center for Hereditary Breast and Ovarian Cancer, Center for Integrated Oncology (CIO) and Center for Molecular Medicine Cologne (CMMC), Medical Faculty, University of Cologne and University Hospital Cologne, Cologne, Germany) ; Kast, Karin (Department of Gynecology and Obstetrics, Technical University of Dresden, Dresden, Germany) ; Arnold, Norbert (Department of Gynaecolgy and Obstetrics, University Hospital of Schleswig-Holstein, Christian-Albrechts-University of Kiel, Kiel, Germany) ; Varon-Mateeva, Raymonda (Institute of Human Genetics, Charité, Berlin, Germany) ; Wand, Dorothea (Institute of Human Genetics, Leipzig, Germany) ; Godwin, Andrew K. (Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS USA) ; Evans, D. Gareth (Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK) ; Frost, Debra (University of Cambridge. Centre for Cancer Genetic Epidemiology) ; Perkins, Jo (University of Cambridge. Centre for Cancer Genetic Epidemiology) ; Adlard, Julian (Yorkshire Regional Genetics Service, Leeds, UK) ; Izatt, Louise (Clinical Genetics, Guy's and St. Thomas' NHS Foundation Trust, London, UK) ; Platte, Radka (Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, UK) ; Eeles, Ros (Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany) ; Ellis, Steve (University of Cambridge. Centre for Cancer Genetic Epidemiology) ; Hamann, Ute (Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany) ; Garber, Judy (Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, Boston, MA USA) ; Fostira, Florentia (Molecular Diagnostics Laboratory, Institute of Nuclear and Radiological Sciences and Technology (INRASTES), National Centre for Scientific Research "Demokritos", Aghia Paraskevi Attikis, Athens, Greece) ; Fountzilas, George (Department of Medical Oncology, Papageorgiou Hospital, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece) ; Pasini, Barbara (AO Città della Salute e della Scienza, Turin, Italy) ; Giannini, Giuseppe (Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena, 324, 00161 Rome, Italy) ; Rizzolo, Piera (Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena, 324, 00161 Rome, Italy) ; Russo, Antonio (Section of Medical Oncology, Department of Surgical and Oncological Sciences, University of Palermo, Palermo, Italy) ; Cortesi, Laura (Department of Oncology and Haematology, University of Modena and Reggio Emilia, Modena, Italy) ; Papi, Laura (Unit of Medical Genetics, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy) ; Varesco, Liliana (Unit of Hereditary Cancer, Department of Epidemiology, Prevention and Special Functions, IRCCS (Scientific Institute of Hospitalization and Care), AOU San Martino - IST National Institute for Cancer Research, Genoa, Italy) ; Palli, Domenico (Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute (ISPO), Florence, Italy) ; Zanna, Ines (Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute (ISPO), Florence, Italy) ; Savarese, Antonella (Unit of Genetic Counselling, Medical Oncology Department, Regina Elena National Cancer Institute, Rome, Italy) ; Radice, Paolo (Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, IRCCS (Scientific Institute of Hospitalization and Care), National Cancer Institute (INT), 20133 Milan, Italy) ; Manoukian, Siranoush (Unit of Medical Genetics, Department of Preventive and Predictive Medicine, IRCCS (Scientific Institute of Hospitalization and Care), National Cancer Institute (INT), Milan, Italy) ; Peissel, Bernard (Unit of Medical Genetics, Department of Preventive and Predictive Medicine, IRCCS (Scientific Institute of Hospitalization and Care), National Cancer Institute (INT), Milan, Italy) ; Barile, Monica (Division of Cancer Prevention and Genetics, European Institute of Oncology (IEO), Milan, Italy) ; Bonanni, Bernardo (Division of Cancer Prevention and Genetics, European Institute of Oncology (IEO), Milan, Italy) ; Viel, Alessandra (Division of Experimental Oncology, CRO Aviano National Cancer Institute, Aviano, PN Italy) ; Pensotti, Valeria (Cogentech Cancer Genetic Test Laboratory, Milan, Italy) ; Tommasi, Stefania (National Cancer Institute "Giovanni Paolo II", Bari, Italy) ; Peterlongo, Paolo (IFOM, FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan, Italy) ; Weitzel, Jeffrey N. (Clinical Cancer Genetics, City of Hope Clinical Cancer Genetics Community Research Network, Duarte, CA USA) ; Osorio, Ana (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Benitez, Javier (Centro Nacional de Investigaciones Oncológicas) ; McGuffog, Lesley (University of Cambridge. Centre for Cancer Genetic Epidemiology) ; Healey, Sue (Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Australia) ; Gerdes, Anne-Marie (Copenhagen University Hospital Rigshospitalet) ; Ejlertsen, Bent (Copenhagen University Hospital Rigshospitalet) ; Hansen, Thomas V. O. (Copenhagen University Hospital Rigshospitalet) ; Steele, Linda (Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA USA) ; Ding, Yuan Chun (Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA USA) ; Tung, Nadine (Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, MA USA) ; Janavicius, Ramunas (State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania) ; Goldgar, David E. (Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT USA) ; Buys, Saundra (Department of Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT USA) ; Daly, Mary B. (Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, PA USA) ; Bane, Anita (Department of Pathology & Molecular Medicine, Juravinski Hospital and Cancer Centre, McMaster University, Hamilton, ON Canada) ; Terry, Mary Beth (Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY USA) ; John, Esther M. (Department of Epidemiology, Cancer Prevention Institute of California, Fremont, CA USA) ; Southey, Melissa (Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, Australia) ; Easton, Douglas F. (University of Cambridge. Centre for Cancer Genetic Epidemiology) ; Chenevix-Trench, Georgia (Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Australia) ; Antoniou, Antonis C. (University of Cambridge. Centre for Cancer Genetic Epidemiology) ; Ottini, Laura (Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena, 324, 00161 Rome, Italy) ; Universitat Autònoma de Barcelona
BRCA1 and, more commonly, BRCA2 mutations are associated with increased risk of male breast cancer (MBC). However, only a paucity of data exists on the pathology of breast cancers (BCs) in men with BRCA1/2 mutations. [...]
2016 - 10.1186/s13058-016-0671-y
Breast cancer research, Vol. 18 (february 2016)  
7.
18 p, 6.6 MB A multilayered post-GWAS assessment on genetic susceptibility to pancreatic cancer / López de Maturana, Evangelina (Centro de Investigación Biomédica en Red de Cáncer) ; Rodríguez, Juan Antonio (Centre de Regulació Genòmica) ; Alonso, Lola (Centro de Investigación Biomédica en Red de Cáncer) ; Lao, Oscar (Centre de Regulació Genòmica) ; Molina-Montes, Esther (Centro de Investigación Biomédica en Red de Cáncer) ; Martín-Antoniano, Isabel Adoración (Centro de Investigación Biomédica en Red de Cáncer) ; Gómez-Rubio, Paulina (Centro de Investigación Biomédica en Red de Cáncer) ; Lawlor, Rita (University and Hospital Trust of Verona. ARC-Net Centre for Applied Research on Cancer and Department of Pathology and Diagnostics) ; Carrato, Alfredo (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ; Hidalgo, Manuel (Weill Cornell Medicine) ; Iglesias, Mar (Parc de Salut MAR de Barcelona) ; Molero, Xavier (Universitat Autònoma de Barcelona. Departament de Medicina) ; Löhr, Matthias (Gastrocentrum, Karolinska Institutet and University Hospital) ; Michalski, Christopher (Martin-Luther-University Halle-WittenberHalle (Saale). Department of Visceral, Vascular and Endocrine Surgery) ; Perea, José (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ; O'Rorke, Michael (The University of Iowa. College of Public Health) ; Barberà, Victor Manuel (Hospital General Universitario de Elche) ; Tardón, Adonina (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ; Farré, Antoni (Institut d'Investigació Biomèdica Sant Pau) ; Muñoz-Bellvís, Luís (Instituto de Investigación Biomédica de Salamanca) ; Crnogorac-Jurcevic, Tanja (Queen Mary University of London. Barts Cancer Institute, Centre for Molecular Oncology) ; Domínguez-Muñoz, Enrique (Complejo Hospitalario Universitario de Santiago de Compostela) ; Gress, Thomas (University Hospital of Giessen and Marburg (Alemanya)) ; Greenhalf, William (University of Liverpool. Department of Molecular and Clinical Cancer Medicine) ; Sharp, Linda (Newcastle University, Institute of Health & Society) ; Arnes, Luís (Columbia University Medical Center. Department of Systems Biology) ; Cecchini, Lluís (Parc de Salut MAR de Barcelona) ; Balsells, Joaquim (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ; Costello, Eithne (University of Liverpool. Department of Molecular and Clinical Cancer Medicine) ; Ilzarbe, Lucas (Parc de Salut MAR de Barcelona) ; Kleeff, Jörg (Martin-Luther-University Halle-WittenberHalle (Saale). Department of Visceral, Vascular and Endocrine Surgery) ; Kong, Bo (Technical University of Munich. Department of Surgery) ; Márquez, Mirari (Centro de Investigación Biomédica en Red de Cáncer) ; Mora Brugués, Josefina (Institut d'Investigació Biomèdica Sant Pau) ; O'Driscoll, Damian (University College Cork. National Cancer Registry Ireland and HRB Clinical Research Facility) ; Scarpa, Aldo (University and Hospital Trust of Verona. ARC-Net Centre for Applied Research on Cancer and Department of Pathology and Diagnostics) ; Ye, Weimin (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics) ; Yu, Jingru (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics) ; García-Closas, Montserrat (Centro Nacional de Investigaciones Oncológicas) ; Kogevinas, M.. (Hospital del Mar (Barcelona, Catalunya)) ; Rothman, Nathaniel (Centro Nacional de Investigaciones Oncológicas) ; Silverman, Debra T. (Centro Nacional de Investigaciones Oncológicas) ; Albanes, Demetrius (Centro Nacional de Investigaciones Oncológicas) ; Arslan, Alan A. (New York University School of Medicine. Department of Population Health) ; Beane-Freeman, Laura (Centro Nacional de Investigaciones Oncológicas) ; Bracci, Paige M. (University of California. Department of Epidemiology and Biostatistics) ; Brennan, Paul (International Agency for Research on Cancer (IARC)) ; Bueno-de-Mesquita, Bas (National Institute for Public Health and the Environment (RIVM). Deparment for Determinants of Chronic Diseases (DCD)) ; Buring, Julie (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ; Canzian, Federico (German Cancer Research Center (DKFZ. Genomic Epidemiology Group) ; Du, Margaret (Memorial Sloan Kettering Cancer Center) ; Gallinger, Steven (Sinai Health System. Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute) ; Gaziano, J. Michael (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ; Goodman, Phyllis J. (SWOG Statistical Center, Fred Hutchinson Cancer Research Center) ; Gunter, Marc (International Agency for Research on Cancer (IARC)) ; LeMarchand, Loic (University of Hawaii Cancer Center. Cancer Epidemiology Program) ; Li, Donghui (University of Texas MD Anderson Cancer Center) ; Neale, Rachael E. (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia). Population Health Department) ; Peters, Ulrika (Fred Hutchinson Cancer Research Center. Division of Public Health Sciences) ; Petersen, Gloria M. (Mayo Clinic College of Medicine. Department of Health Sciences Research) ; Risch, Harvey A. (Yale School of Public Health. Department of Chronic Disease Epidemiology) ; Sánchez, Maria José (Universidad de Granada) ; Shu, Xiao-Ou (Vanderbilt University School of Medicine. Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center) ; Thornquist, Mark D. (Fred Hutchinson Cancer Research Center. Division of Public Health Sciences) ; Visvanathan, Kala (Mayo Clinic College of Medicine. Department of Health Sciences Research) ; Zheng, Wei (Vanderbilt University School of Medicine. Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center) ; Chanock, Stephen (Centro Nacional de Investigaciones Oncológicas) ; Easton, Douglas F (University of Cambridge. Centre for Cancer Genetic Epidemiology) ; Wolpin, Brian M. (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica)) ; Stolzenberg-Solomon, Rachael Z. (Centro Nacional de Investigaciones Oncológicas) ; Klein, Alison P. (Johns Hopkins School of Medicine. Department of Oncology, Sidney Kimmel Comprehensive Cancer Center) ; Amundadottir, Laufey T. (National Cancer Institute (Bethesda, Estats Units d'Amèrica)) ; Marti-Renom, Marc A. (Universitat Pompeu Fabra. Centre de Regulació Genòmica (CRG-UPF)) ; Real, Francisco X (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ; Malats, Núria (Centro de Investigación Biomédica en Red de Cáncer)
Pancreatic cancer (PC) is a complex disease in which both non-genetic and genetic factors interplay. To date, 40 GWAS hits have been associated with PC risk in individuals of European descent, explaining 4. [...]
2021 - 10.1186/s13073-020-00816-4
Genome Medicine, Vol. 13 (february 2021)  
8.
14 p, 1.9 MB The FANCM :p.Arg658* truncating variant is associated with risk of triple-negative breast cancer / Figlioli, Gisella (The FIRC Institute for Molecular Oncology) ; Bogliolo, Massimo (Institut d'Investigació Biomèdica Sant Pau) ; Catucci, Irene (The FIRC Institute for Molecular Oncology) ; Caleca, Laura (Istituto Nazionale dei Tumori, Department of Research) ; Viz Lasheras, Sandra (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Pujol, Roser (Institut d'Investigació Biomèdica Sant Pau) ; Kiiski, Johanna I. (University of Helsinki, Department of Obstetrics and Gynecology) ; Muranen, Taru A. (University of Helsinki, Department of Obstetrics and Gynecology) ; Barnes, Daniel R. (University of Cambridge, Department of Public Health and Primary Care) ; Dennis, Joe (University of Cambridge, Department of Public Health and Primary Care) ; Michailidou, Kyriaki (The Cyprus Institute of Neurology & Genetics, Department of Electron Microscopy) ; Bolla, Manjeet K. (University of Cambridge, Department of Public Health and Primary Care) ; Leslie, Goska (University of Cambridge, Department of Public Health and Primary Care) ; Aalfs, Cora M. (Amsterdam UMC, Department of Clinical Genetics) ; Adank, Muriel A. (The Netherlands Cancer Institute (Amsterdam, Països Baixos)) ; Adlard, Julian (Chapel Allerton Hospital) ; Agata, Simona (Veneto Institute of Oncology (Pàdua, Itàlia)) ; Cadoo, Karen (Memorial Sloan Kettering Cancer Center) ; Agnarsson, Bjarni A. (University of Iceland, School of Medicine) ; Ahearn, Thomas (National Cancer Institute) ; Aittomäki, Kristiina (University of Helsinki, Department of Clinical Genetics) ; Ambrosone, Christine B. (Roswell Park Cancer Institute) ; Andrews, Lesley (Nelune Comprehensive Cancer Care Centre) ; Anton-Culver, Hoda (University of California Irvine, Department of Epidemiology) ; Antonenkova, Natalia N. (N.N. Alexandrov Research Institute of Oncology and Medical Radiology) ; Arndt, Volker (German Cancer Research Center) ; Arnold, Norbert (University Hospital of Schleswig-Holstein, Department of Gynaecology and Obstetrics) ; Aronson, Kristan J. (Queen's University, Department of Public Health Sciences) ; Arun, Banu K. (University of Texas, Department of Breast Medical Oncology) ; Asseryanis, Ella (Medical University of Vienna, Dept of OB/GYN and Comprehensive Cancer Center) ; Auber, Bernd (Institute of Human Genetics) ; Auvinen, Päivi (University of Eastern Finland, Translational Cancer Research Area) ; Azzollini, Jacopo (Fondazione Istituto Nazionale dei Tumori di Milano, Department of Medical Oncology and Hematology) ; Balmaña Gelpí, Judith (Hospital Universitari Vall d'Hebron) ; Barkardottir, Rosa B. (University of Iceland) ; Barrowdale, Daniel (University of Cambridge, Department of Public Health and Primary Care) ; Barwell, Julian (Leicester General Hospital (Leicester, Regne Unit)) ; Beane-Freeman, Laura (National Cancer Institute) ; Beauparlant, Charles Joly (Centre Hospitalier Universitaire de Québec - Université Laval) ; Beckmann, Matthias W. (Friedrich-Alexander-University Erlangen-Nuremberg, Department of Gynecology and Obstetrics) ; Behrens, Sabine (German Cancer Research Center) ; Benitez, Javier (Centro Nacional de Investigaciones Oncológicas) ; Berger, Raanan (Chaim Sheba Medical Center. The Institute of Oncology) ; Bermisheva, Marina (Institute of Biochemistry and Genetics) ; Blanco, Amie M. (University of California San Francisco) ; Blomqvist, Carl (Örebro University Hospital, Department of Oncology) ; Bogdanova, Natalia V. (Hannover Medical School) ; Bojesen, Anders (Aarhus University Hospital (Aarhus, Dinamarca)) ; Bojesen, Stig E. (University of Copenhagen) ; Bonanni, Bernardo (IEO, European Institute of Oncology) ; Borg, Åke (Skåne University Hospital (Suècia)) ; Brady, Angela F. (London North West University Hospitals) ; Brauch, Hiltrud (German Cancer Research Center) ; Brenner, Hermann (German Cancer Research Center) ; Brüning, Thomas (Institute of the Ruhr University Bochum) ; Burwinkel, Barbara (University of Heidelberg) ; Buys, Saundra (Huntsman Cancer Institute, Department of Medicine) ; Caldes, Trinidad (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ; Caliebe, Almuth (Universitätsklinikum Schleswig-Holstein (Alemanya)) ; Caligo, Maria (University Hospital of Pisa (Pisa, Itàlia)) ; Campa, Daniele (University of Pisa, Department of Biology) ; Campbell, Ian (The University of Melbourne, Department of Oncology) ; Canzian, Federico (German Cancer Research Center) ; Castelao, Jose E. (Instituto de Investigación Sanitaria Galicia Sur) ; Chang-Claude, Jenny (University Medical Center Hamburg-Eppendorf) ; Chanock, Stephen J. (National Cancer Institute) ; Claes, Kathleen (Ghent University, Centre for Medical Genetics) ; Clarke, Christine L. (University of Sydney, Westmead Institute for Medical Research) ; Collavoli, Anita (University Hospital of Pisa (Pisa, Itàlia)) ; Conner, Thomas A. (Huntsman Cancer Institute (Salt Lake City, Estats Units d'Amèrica)) ; Cox, David G. (Cancer Research Center of Lyon) ; Cybulski, Cezary (Pomeranian Medical University, Department of Genetics and Pathology) ; Czene, Kamila (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics) ; Daly, Mary B. (Fox Chase Cancer Center, Department of Clinical Genetics) ; De la Hoya, Miguel (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ; Devilee, Peter (Leiden University Medical Center, Department of Human Genetics) ; Diez, Orland (Hospital Universitari Vall d'Hebron) ; Ding, Yuan Chun (Beckman Research Institute of City of Hope (Duarte, Estats Units d'Amèrica). Department of Population Sciences) ; Dite, Gillian S. (The University of Melbourne) ; Ditsch, Nina (Ludwig Maximilian University of Munich, Department of Gynecology and Obstetrics) ; Domchek, Susan M. (Perelman School of Medicine at the University of Pennsylvania, Department of Medicine) ; Dorfling, Cecilia M. (University of Pretoria, Department of Genetics) ; dos-Santos-Silva, Isabel (London School of Hygiene and Tropical Medicine, Department of Non-Communicable Disease Epidemiology) ; Durda, Katarzyna (Pomeranian Medical University, Department of Genetics and Pathology) ; Dwek, Miriam (University of Westminster, Department of Biomedical Sciences) ; Eccles, Diana M. (University of Southampton, Cancer Sciences Academic Unit) ; Ekici, Arif B. (Friedrich-Alexander University Erlangen-Nuremberg) ; Eliassen, A. Heather (Harvard T.H. Chan School of Public Health, Department of Epidemiology) ; Ellberg, Carolina (Lund University, Department of Cancer Epidemiology) ; Eriksson, Mikael (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics) ; Evans, D. Gareth (Manchester University NHS Foundation Trust) ; Fasching, Peter A. (University of California at Los Angeles, Department of Medicine Division of Hematology and Oncology) ; Figueroa, Jonine (Cancer Research UK Edinburgh Centre) ; Flyger, Henrik (Copenhagen University Hospital) ; Foulkes, William D. (McGill University, Departments of Human Genetics and Oncology) ; Friebel, Tara M. (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica)) ; Friedman, Eitan (Tel Aviv University) ; Gabrielson, Marike (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics) ; Gaddam, Pragna (Memorial Sloan-Kettering Cancer Center (Nova York, Estats Units d'Amèrica)) ; Gago-Dominguez, Manuela (University of California San Diego) ; Gao, Chi (Harvard T.H. Chan School of Public Health (Boston, Estats Units d'Amèrica)) ; Gapstur, Susan M. (American Cancer Society) ; Garber, Judy (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica)) ; García-Closas, Montserrat (National Cancer Institute) ; García-Sáenz, José A. (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ; Gaudet, Mia M. (American Cancer Society) ; Gayther, Simon A. (Cedars Sinai Heart Institute (Los Angeles, Estats Units d'Amèrica)) ; Giles, Graham G. (Monash University, Department of Epidemiology and Preventive Medicine) ; Glendon, Gord (Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital) ; Godwin, Andrew K. (Kansas University Medical Center, Department of Pathology and Laboratory Medicine) ; Goldberg, Mark S. (McGill University) ; Goldgar, David E. (University of Utah School of Medicine, Department of Dermatology) ; Guénel, Pascal (University Paris-Sud, University Paris-Saclay) ; Gutierrez-Barrera, Angelica M. (University of Texas, Department of Breast Medical Oncology and Clinical Genetics Program) ; Haeberle, Lothar (University Hospital Erlangen (Alemanya)) ; Haiman, Christopher A. (University of Southern California, Department of Preventive Medicine) ; Håkansson, Niclas (Karolinska Institutet, Institute of Environmental Medicine) ; Hall, Per (Södersjukhuset, Department of Oncology) ; Hamann, Ute (German Cancer Research Center) ; Harrington, Patricia A. (University of Cambridge, Department of Oncology) ; Hein, Alexander (University Hospital Erlangen (Alemanya)) ; Heyworth, Jane (The University of Western Australia) ; Hillemanns, Peter (Hannover Medical School, Gynaecology Research Unit) ; Hollestelle, Antoinette (Erasmus MC Cancer Institute) ; Hopper, John L. (The University of Melbourne) ; Hosgood, H. Dean (Albert Einstein College of Medicine) ; Howell, Anthony (University of Manchester, Division of Cancer Sciences) ; Hu, Chunling (Mayo Clinic, Department of Laboratory Medicine and Pathology) ; Hulick, Peter J. (The University of Chicago Pritzker School of Medicine) ; Hunter, David J. (University of Oxford) ; Imyanitov, Evgeny N. (N.N. Petrov Institute of Oncology) ; Isaacs, Claudine (Georgetown University) ; Jakimovska, Milena (Macedonian Academy of Sciences and Arts) ; Jakubowska, Anna (Pomeranian Medical University) ; James, Paul (Peter MacCallum Cancer Center) ; Janavicius, Ramunas (State Research Institute Innovative Medicine Center) ; Janni, Wolfgang (University Hospital of Ulm (Alemanya)) ; John, Esther M. (Stanford University School of Medicine, Department of Medicine) ; Jones, Michael E. (The Institute of Cancer Research) ; Jung, Audrey (German Cancer Research Center) ; Kaaks, Rudolf (German Cancer Research Center) ; Karlan, Beth Y. (Cedars Sinai Heart Institute (Los Angeles, Estats Units d'Amèrica)) ; Khusnutdinova, Elza (Bashkir State Medical University, Department of Medical Genetics) ; Kitahara, Cari M. (National Cancer Institute) ; Konstantopoulou, Irene (National Centre for Scientific Research 'Demokritos') ; Koutros, Stella (National Cancer Institute) ; Kraft, Peter (Harvard T.H. Chan School of Public Health (Boston, Estats Units d'Amèrica)) ; Lambrechts, Diether (University of Leuven, Department of Human Genetics) ; Lazaro, Conxi (Institut d'Investigació Biomèdica de Bellvitge) ; Le Marchand, Loic (University of Hawaii Cancer Center, Epidemiology Program) ; Lester, Jenny (Cedars Sinai Heart Institute (Los Angeles, Estats Units d'Amèrica)) ; Lesueur, Fabienne (Mines ParisTech) ; Lilyquist, Jenna (Mayo Clinic, Department of Health Sciences Research) ; Loud, Jennifer T. (National Cancer Institute, Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics) ; Lu, Karen H. (University of Texas MD Anderson Cancer Center, Department of Gynecologic Oncology) ; Luben, Robert N. (University of Cambridge, Department of Public Health and Primary Care) ; Lubinski, Jan (Pomeranian Medical University, Department of Genetics and Pathology) ; Mannermaa, Arto (Kuopio University Hospital ( Finlàndia)) ; Manoochehri, Mehdi (German Cancer Research Center) ; Manoukian, Siranoush (Istituto Nazionale dei Tumori di Milano) ; Margolin, Sara (Karolinska Institutet, Department of Clinical Science and Education) ; Martens, John W. M. (Erasmus MC Cancer Institute) ; Maurer, Tabea (University Medical Center Hamburg-Eppendorf) ; Mavroudis, Dimitrios (University Hospital of Heraklion, Department of Medical Oncology) ; Mebirouk, Noura (Mines ParisTech) ; Meindl, Alfons (Ludwig Maximilian University of Munich, Department of Gynecology and Obstetrics) ; Menon, Usha (University College London) ; Miller, Austin (Roswell Park Cancer Institute) ; Montagna, Marco (Veneto Institute of Oncology (Pàdua, Itàlia)) ; Nathanson, Katherine L. (University of Pennsylvania, Department of Medicine) ; Neuhausen, Susan L. (Beckman Research Institute of City of Hope (Duarte, Estats Units d'Amèrica). Department of Population Sciences) ; Newman, William G. (Manchester University NHS Foundation Trust) ; Nguyen-Dumont, Tu (The University of Melbourne, Department of Clinical Pathology) ; Nielsen, Finn Cilius (Copenhagen University Hospital) ; Nielsen, Sarah (The University of Chicago, Center for Clinical Cancer Genetics) ; Nikitina-Zake, Liene (Latvian Biomedical Research and Study Centre) ; Offit, Kenneth (Memorial Sloan-Kettering Cancer Center, Clinical Genetics Service, Department of Medicine) ; Olah, Edith (National Institute of Oncology, Department of Molecular Genetics) ; Olopade, Olufunmilayo I. (The University of Chicago) ; Olshan, Andrew F. (University of North Carolina at Chapel Hill, Department of Epidemiology) ; Olson, Janet E. (Mayo Clinic, Department of Health Sciences Research) ; Olsson, Håkan (Lund University, Department of Cancer Epidemiology, Clinical Sciences) ; Osorio, Ana (Spanish Network on Rare Diseases) ; Ottini, Laura (University La Sapienza, Department of Molecular Medicine) ; Peissel, Bernard (Istituto Nazionale dei Tumori di Milano) ; Peixoto, Ana (Portuguese Oncology Institute, Department of Genetics) ; Peto, Julian (London School of Hygiene and Tropical Medicine, Department of Non-Communicable Disease Epidemiology) ; Plaseska-Karanfilska, Dijana (Macedonian Academy of Sciences and Arts) ; Pocza, Timea (National Institute of Oncology, Department of Molecular Genetics) ; Presneau, Nadege (University of Westminster, Department of Biomedical Sciences) ; Pujana, Miquel Angel (Institut d'Investigació Biomèdica de Bellvitge) ; Punie, Kevin (University Hospitals Leuven (Bèlgica)) ; Rack, Brigitte (University Hospital of Ulm (Alemanya)) ; Rantala, Johanna (Karolinska Institutet, Clinical Genetics) ; Rashid, Muhammad U. (Shaukat Khanum Memorial Cancer Hospital and Research Centre, Department of Basic Sciences) ; Rau-Murthy, Rohini (Memorial Sloan-Kettering Cancer Center, Department of Medicine) ; Rennert, Gad (Clalit National Cancer Control Center) ; Lejbkowicz, Flavio (Clalit National Cancer Control Center) ; Rhenius, Valerie (University of Cambridge. Centre for Cancer Genetic Epidemiology) ; Romero, Atocha (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ; Rookus, Matti A. (The Netherlands Cancer Institute, Department of Epidemiology) ; Ross, Eric A. (Fox Chase Cancer Center) ; Rossing, Maria (Copenhagen University Hospital) ; Rudaitis, Vilius (Vilnius University, Institute of Clinical Medicine) ; Ruebner, Matthias (University Hospital Erlangen. Friedrich-Alexander University Erlangen-Nuremberg, Department of Gynaecology and Obstetrics) ; Saloustros, Emmanouil (General University Hospital of Larissa (Grècia)) ; Sanden, Kristin (University of Wisconsin, Cancer Center at ProHealth Care) ; Santamariña, Marta (Instituto de Investigación Sanitaria de Santiago (IDIS)) ; Scheuner, Maren T. (University of California San Francisco, Cancer Genetics and Prevention Program) ; Schmutzler, Rita K. (University of Cologne, Center for Molecular Medicine Cologne) ; Schneider, Michael (University Hospital Erlangen (Alemanya)) ; Scott, Christopher (Mayo Clinic, Department of Health Sciences Research) ; Senter, Leigha (The Ohio State University, Department of Internal Medicine) ; Shah, Mitul (University of Cambridge, Department of Oncology) ; Sharma, Priyanka (University of Kansas Medical Center, Department of Internal Medicine) ; Shu, Xiao-Ou (Vanderbilt University School of Medicine, Department of Medicine) ; Simard, Jacques (Université Laval) ; Singer, Christian F. (Medical University of Vienna) ; Sohn, Christof (University of Heidelberg) ; Soucy, Penny (Université Laval) ; Southey, Melissa C. (The University of Melbourne, Department of Clinical Pathology) ; Spinelli, John J. (University of British Columbia, School of Population and Public Health) ; Steele, Linda (Beckman Research Institute of City of Hope (Duarte, Estats Units d'Amèrica). Department of Population Sciences) ; Stoppa-Lyonnet, Dominique (Université Paris Descartes) ; Tapper, William J. (University of Southampton) ; Teixeira, Manuel R. (University of Porto) ; Terry, Mary Beth (Columbia University, Department of Epidemiology) ; Thomassen, Mads (Odense University Hospital (Dinamarca)) ; Thompson, Jennifer (NorthShore University HealthSystem, Center for Medical Genetics) ; Thull, Darcy L. (University of Pittsburgh School of Medicine, Department of Medicine) ; Tischkowitz, Marc (University of Cambridge, Department of Medical Genetics) ; Tollenaar, Rob A. E. M. (Leiden University Medical Center, Department of Surgery) ; Torres, Diana (Pontificia Universidad Javeriana) ; Troester, Melissa A. (University of North Carolina at Chapel Hill) ; Truong, Thérèse (University Paris-Sud) ; Tung, Nadine (Beth Israel Deaconess Medical Center, Department of Medical Oncology) ; Untch, Michael (Helios Clinics Berlin-Buch, Department of Gynecology and Obstetrics) ; Vachon, Celine M. (Mayo Clinic, Department of Health Sciences Research) ; van Rensburg, Elizabeth J. (University of Pretoria, Department of Genetics) ; van Veen, Elke M. (Manchester University NHS Foundation Trust) ; Vega, Ana (Instituto de Investigación Sanitaria de Santiago (IDIS)) ; Viel, Alessandra (Centro di Riferimento Oncologico di Aviano) ; Wappenschmidt, Barbara (University of Cologne, Center for Molecular Medicine Cologne) ; Weitzel, Jeffrey N. (City of Hope, Clinical Cancer Genetics) ; Wendt, Camilla (Karolinska Institutet (Estocolm, Suècia)) ; Wieme, Greet (Ghent University, Centre for Medical Genetics) ; Wolk, Alicja (Uppsala University, Department of Surgical Sciences) ; Yang, Xiaohong R. (National Cancer Institute) ; Zheng, Wei (Vanderbilt University School of Medicine) ; Ziogas, Argyrios (University of California Irvine, Department of Epidemiology) ; Zorn, Kristin K. (University of Pittsburgh School of Medicine) ; Dunning, Alison M. (University of Cambridge, Department of Oncology) ; Lush, Michael (University of Cambridge, Department of Public Health and Primary Care) ; Wang, Qin (University of Cambridge, Department of Public Health and Primary Care) ; McGuffog, Lesley (University of Cambridge, Department of Public Health and Primary Care) ; Parsons, Michael T. (QIMR Berghofer Medical Research Institute, Department of Genetics and Computational Biology) ; Pharoah, Paul D. P. (University of Cambridge. Centre for Cancer Genetic Epidemiology) ; Fostira, Florentia (National Centre for Scientific Research 'Demokritos') ; Toland, Amanda E. (The Ohio State University, Department of Cancer Biology and Genetics) ; Andrulis, Irene L. (University of Toronto, Department of Molecular Genetics) ; Ramus, Susan J. (The Kinghorn Cancer Centre, Garvan Institute of Medical Research) ; Swerdlow, Anthony J. (The Institute of Cancer Research) ; Greene, Mark H. (National Cancer Institute, Clinical Genetics Branch) ; Chung, Wendy (Columbia University, Departments of Pediatrics and Medicine) ; Milne, Roger L. (Monash University) ; Chenevix-Trench, Georgia (QIMR Berghofer Medical Research Institute, Department of Genetics and Computational Biology) ; Dörk, Thilo (Hannover Medical School) ; Schmidt, Marjanka K. (The Netherlands Cancer Institute (Amsterdam, Països Baixos)) ; Easton, Douglas F. (University of Cambridge, Department of Oncology) ; Radice, Paolo (Istituto Nazionale dei Tumori) ; Hahnen, Eric (University of Cologne) ; Antoniou, Antonis C. (University of Cambridge, Department of Public Health and Primary Care) ; Couch, Fergus J. (Mayo Clinic, Department of Laboratory Medicine and Pathology) ; Nevanlinna, Heli (University of Helsinki, Department of Obstetrics and Gynecology) ; Surrallés i Calonge, Jordi (Institut d'Investigació Biomèdica Sant Pau) ; Peterlongo, Paolo (The FIRC Institute for Molecular Oncology)
Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. [...]
2019 - 10.1038/s41523-019-0127-5
NPJ breast cancer, Vol. 5 (November 2019) , art. 38  
9.
50 p, 22.6 MB Pan-cancer analysis of whole genomes / Campbell, Peter J. (Wellcome Trust Sanger Institute (Regne Unit)) ; Getz, Gad (Harvard Medical School) ; Korbel, Jan O. (European Molecular Biology Laboratory (EMBL). Genome Biology Unit) ; Stuart, Joshua M. (Biomolecular Engineering Department. University of California Santa Cruz) ; Jennings, Jennifer L. (International Cancer Genome Consortium (ICGC)/ICGC Accelerating Research in Genomic Oncology (ICGC-ARGO) Secretariat) ; Stein, Lincoln D. (Department of Molecular Genetics. University of Toronto) ; Perry, Marc D. (Genome Informatics Program. Ontario Institute for Cancer Research) ; Nahal-Bose, Hardeep K. (Genome Informatics Program. Ontario Institute for Cancer Research) ; Ouellette, B. F. Francis (Genome Informatics. Ontario Institute for Cancer Research) ; Li, Constance H. (Department of Medical Biophysics. University of Toronto) ; Rheinbay, Esther (Massachusetts General Hospital (Boston)) ; Nielsen, G. Petur (Massachusetts General Hospital (Boston)) ; Sgroi, Dennis C. (Massachusetts General Hospital (Boston)) ; Wu, Chin-Lee (Massachusetts General Hospital (Boston)) ; Faquin, William C. (Massachusetts General Hospital (Boston)) ; Deshpande, Vikram (Massachusetts General Hospital (Boston)) ; Boutros, Paul C. (University of California Los Angeles) ; Lazar, Aalexander J. (Department of Pathology. Department of Genomic Medicine and Department of Translational Molecular Pathology. The University of Texas MD Anderson Cancer Center) ; Hoadley, Katherine A. (Lineberger Comprehensive Cancer Center. University of North Carolina at Chapel Hill) ; Louis, David N. (Massachusetts General Hospital (Boston)) ; Yung, Christina K. (Genome Informatics Program. Ontario Institute for Cancer Research) ; Bailey, Matthew H. (The McDonnell Genome Institute. Washington University) ; Saksena, Gordon (Broad Institute of MIT and Harvard) ; Raine, Keiran M. (Wellcome Trust Sanger Institute (Regne Unit)) ; Buchhalter, Ivo (Institute of Pharmacy and Molecular Biotechnology. and BioQuant. Heidelberg University) ; Kleinheinz, Kortine (Institute of Pharmacy and Molecular Biotechnology. and BioQuant. Heidelberg University) ; Schlesner, Matthias (Bioinformatics and Omics Data Analytics. German Cancer Research Center (DKFZ)) ; Zhang, Jiashan (National Cancer Institute. National Institutes of Health) ; Wang, Wenyi (Department of Bioinformatics and Computational Biology. The University of Texas MD Anderson Cancer Center) ; Wheeler, David A. (Baylor College of Medicine. Department of Molecular and Human Genetics) ; Ding, Li (Department of Genetics and Department of Medicine. Washington University in St Louis) ; Simpson, Jared T. (Department of Computer Science. University of Toronto) ; O'Connor, Brian D. (University of California Santa Cruz) ; Yakneen, Sergei (European Molecular Biology Laboratory (EMBL). Genome Biology Unit) ; Ellrott, Kyle (Computational Biology Program. Oregon Health & Science University) ; Miyoshi, Naoki (The Institute of Medical Science. The University of Tokyo) ; Butler, Adam P. (Wellcome Trust Sanger Institute (Regne Unit)) ; Royo, Romina (Barcelona Supercomputing Center) ; Shorser, Solomon I. (Computational Biology Program. Ontario Institute for Cancer Research) ; Vazquez, Miguel (Department of Clinical and Molecular Medicine. Faculty of Medicine and Health Sciences. Norwegian University of Science and Technology) ; Rausch, Tobias (European Molecular Biology Laboratory (EMBL). Genome Biology Unit) ; Tiao, Grace (Broad Institute of MIT and Harvard) ; Waszak, Sebastian M. (European Molecular Biology Laboratory (EMBL). Genome Biology Unit) ; Rodriguez-Martin, Bernardo (The Biomedical Research Centre (CINBIO). Universidade de Vigo) ; Shringarpure, Suyash (Department of Genetics. Stanford University School of Medicine) ; Wu, Dai-Ying (Annai Systems) ; Demidov, German M. (Universitat Pompeu Fabra) ; Delaneau, Olivier (Swiss Institute of Bioinformatics. University of Geneva) ; Hayashi, Shuto (The Institute of Medical Science. The University of Tokyo) ; Imoto, Seiya (The Institute of Medical Science. The University of Tokyo) ; Habermann, Nina (European Molecular Biology Laboratory (EMBL). Genome Biology Unit) ; Segre, Ayellet V. (Department of Ophthalmology. Ocular Genomics Institute. Massachusetts Eye and Ear. Harvard Medical School) ; Garrison, Erik (Wellcome Trust Sanger Institute (Regne Unit)) ; Cafferkey, Andy (European Molecular Biology Laboratory (EMBL). European Bioinformatics Institute (EMBL-EBI)) ; Alvarez, Eva G. (The Biomedical Research Centre (CINBIO). Universidade de Vigo) ; Heredia-Genestar, José María (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ; Muyas, Francesc (Universitat Pompeu Fabra) ; Drechsel, Oliver (Universitat Pompeu Fabra) ; Bruzos, Alicia L. (The Biomedical Research Centre (CINBIO). Universidade de Vigo) ; Temes, Javier (Department of Zoology. Genetics and Physical Anthropology. Centre for Research in Molecular Medicine and Chronic Diseases (CiMUS). Universidade de Santiago de Compostela) ; Zamora, Jorge (Wellcome Trust Sanger Institute (Regne Unit)) ; Baez-Ortega, Adrian (Department of Veterinary Medicine. Transmissible Cancer Group. University of Cambridge) ; Kim, Hyung-Lae (Department of Biochemistry. College of Medicine. Ewha Womans University) ; Mashl, R. Jay (Division of Oncology. Washington University School of Medicine) ; Ye, Kai (The First Affiliated Hospital. Xi'an Jiaotong University) ; DiBiase, Anthony (Independent Consultant) ; Huang, Kuan-Lin (Icahn School of Medicine at Mount Sinai) ; Letunic, Ivica (Biobyte Solutions) ; McLellan, Michael D. (Department of Genetics and Department of Medicine. Washington University in St Louis) ; Newhouse, Steven J. (European Molecular Biology Laboratory (EMBL). European Bioinformatics Institute (EMBL-EBI)) ; Shmaya, Tal (Annai Systems) ; Kumar, Sushant (Program in Computational Biology and Bioinformatics. Yale University) ; Wedge, David C. (Wellcome Trust Sanger Institute (Regne Unit)) ; Wright, Mark H. (Department of Genetics. Stanford University School of Medicine) ; Yellapantula, Venkata D. (The McDonnell Genome Institute at Washington University School of Medicine. and Department of Genetics and Department of Medicine. Siteman Cancer Center. Washington University in St Louis) ; Gerstein, Mark (Department of Computer Science. Yale University) ; Khurana, Ekta (Institute for Computational Biomedicine. Weill Cornell Medicine) ; Marques-Bonet, Tomas 1975- (Institut Català de Paleontologia Miquel Crusafont) ; Navarro, Arcadi, 1969- (Institució Catalana de Recerca i Estudis Avançats) ; Bustamante, Carlos D. (Department of Biomedical Data Science. Stanford University School of Medicine) ; Siebert, Reiner (Institute of Human Genetics. Ulm University and Ulm University Medical Center) ; Nakagawa, Hidewaki (RIKEN Center for Integrative Medical Sciences) ; Easton, Douglas F (University of Cambridge. Centre for Cancer Genetic Epidemiology) ; Ossowski, Stephan (Universitat Pompeu Fabra) ; Tubio, Jose M. C. (The Biomedical Research Centre (CINBIO). Universidade de Vigo) ; De La Vega, Francisco M. (Department of Biomedical Data Science. Stanford University School of Medicine) ; Estivill, Xavier (Quantitative Genomics Laboratories (qGenomics)) ; Yuen, Denis (Computational Biology Program. Ontario Institute for Cancer Research) ; Mihaiescu, George L. (Genome Informatics Program. Ontario Institute for Cancer Research) ; Omberg, Larsson (Sage Bionetworks) ; Ferretti, Vimcent (Department of Biochemistry and Molecular Medicine. University of Montreal. Montreal) ; Sabarinathan, Radhakrishnan (Universitat Pompeu Fabra. Unitat de Recerca en Informàtica Biomèdica (GRIB)) ; Pich, Oriol (Institute for Research in Biomedicine (IRB Barcelona)) ; Taylor-Weiner, Amaro (Broad Institute of MIT and Harvard) ; Demeulemeester, Jonas (University of Leuven) ; Tarabichi, Maxime (Wellcome Trust Sanger Institute (Regne Unit)) ; Roberts, Nicola Diane (Wellcome Trust Sanger Institute (Regne Unit)) ; Van Loo, Peter (University of Leuven) ; Cortés-Ciriano, Isidro (Ludwig Center at Harvard Medical School) ; Urban, Lara (European Molecular Biology Laboratory (EMBL). Genome Biology Unit) ; Zhu, Bin (Division of Cancer Epidemiology and Genetics. National Cancer Institute. National Institutes of Health) ; Pitkänen, Esa (European Molecular Biology Laboratory (EMBL). Genome Biology Unit) ; Li, Yilong (Wellcome Trust Sanger Institute (Regne Unit)) ; Saini, Natalie (Genome Integrity and Structural Biology Laboratory. National Institute of Environmental Health Sciences (NIEHS)) ; Klimczak, Leszek J. (Integrative Bioinformatics Support Group. National Institute of Environmental Health Sciences (NIEHS)) ; Weischenfeldt, Joachim (Finsen Laboratory and Biotech Research & Innovation Centre (BRIC). University of Copenhagen) ; Sidiropoulos, Nikos (Finsen Laboratory and Biotech Research & Innovation Centre (BRIC). University of Copenhagen) ; Alexandrov, Ludmil B. (Wellcome Trust Sanger Institute (Regne Unit)) ; Rabionet, Raquel (Universitat de Barcelona. Institut de Biomedicina) ; Escaramis, Georgia (Universitat de Girona. Grup de Recerca en Estadística, Econometria i Salut) ; Bosio, Mattia (Universitat Pompeu Fabra) ; Holik, Aliaksei Z. (Centre de Regulació Genòmica) ; Susak, Hana (Universitat Pompeu Fabra) ; Prasad, Aparna (Universitat Pompeu Fabra) ; Erkek, Serap (European Molecular Biology Laboratory (EMBL). Genome Biology Unit) ; Calabrese, Claudia (European Molecular Biology Laboratory (EMBL). Genome Biology Unit) ; Raeder, Benjamin (European Molecular Biology Laboratory (EMBL). Genome Biology Unit) ; Harrington, Eoghan (Oxford Nanopore Technologies) ; Mayes, Simon (Applications Department. Oxford Nanopore Technologies) ; Turner, Daniel J. (Applications Department. Oxford Nanopore Technologies) ; Juul, Sissel (Oxford Nanopore Technologies) ; Roberts, Steven A. (School of Molecular Biosciences and Center for Reproductive Biology. Washington State University) ; Song, Lei (Division of Cancer Epidemiology and Genetics. National Cancer Institute. National Institutes of Health) ; Koster, Roelof (Laboratory of Translational Genomics. Division of Cancer Epidemiology and Genetics. National Cancer Institute. National Institutes of Health) ; Mirabello, Lisa (Division of Cancer Epidemiology and Genetics. National Cancer Institute. National Institutes of Health) ; Hua, Xing (Division of Cancer Epidemiology and Genetics. National Cancer Institute. National Institutes of Health) ; Tanskanen, Tomas J. (Department of Medical and Clinical Genetics. Genome-Scale Biology Research Program. University of Helsinki) ; Tojo, Marta (The Biomedical Research Centre (CINBIO). Universidade de Vigo) ; Chen, Jieming (Integrated Graduate Program in Physical and Engineering Biology. Yale University) ; Aaltonen, Lauri A. (Applied Tumor Genomics Research Program. Research Programs Unit. University of Helsinki) ; Rätsch, Gunnar (Weill Cornell Medical College) ; Schwarz, Roland F. (German Cancer Research Center (DKFZ)) ; Butte, Atul J. (Bakar Computational Health Sciences Institute and Department of Pediatrics. University of California) ; Brazma, Alvis (European Molecular Biology Laboratory (EMBL). European Bioinformatics Institute (EMBL-EBI)) ; Chanock, Stephen J. (Division of Cancer Epidemiology and Genetics. National Cancer Institute. National Institutes of Health) ; Chatterjee, Nilanjan (Department of Oncology. The Johns Hopkins School of Medicine. The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University) ; Stegle, Oliver (Division of Computational Genomics and Systems Genetics. German Cancer Research Center (DKFZ)) ; Harismendy, Olivier (Department of Medicine and Moores Cancer Center. Division of Biomedical Informatics. UC San Diego School of Medicine) ; Bova, George Steven (Faculty of Medicine and Health Technology. Tampere University and Tays Cancer Center. Tampere University Hospital) ; Gordenin, Dmitry A. (Genome Integrity and Structural Biology Laboratory. National Institute of Environmental Health Sciences (NIEHS)) ; Haan, David (Biomolecular Engineering Department. University of California Santa Cruz) ; Sieverling, Lina (Faculty of Biosciences. Heidelberg University) ; Feuerbach, Lars (Division of Applied Bioinformatics. German Cancer Research Center (DKFZ)) ; Chalmers, Don (Centre for Law and Genetics. University of Tasmania) ; Joly, Yann (Centre of Genomics and Policy. McGill University and Génome Québec Innovation Centre. Montreal) ; Knoppers, Bartha (Centre of Genomics and Policy. McGill University and Génome Québec Innovation Centre. Montreal) ; Molnár-Gábor, Fruzsina (Heidelberg Academy of Sciences and Humanities) ; Phillips, Mark (Centre of Genomics and Policy. McGill University and Génome Québec Innovation Centre. Montreal) ; Thorogood, Adrian (Centre of Genomics and Policy. McGill University and Génome Québec Innovation Centre. Montreal) ; Townend, David (CAPHRI Research School. Maastricht University) ; Goldman, Mary J. (UC Santa Cruz Genomics Institute. University of California Santa Cruz) ; Fonseca, Nuno A. (CIBIO/InBIO. Research Center in Biodiversity and Genetic Resources. Universidade do Porto) ; Xiang, Qian (Ontario Institute for Cancer Research) ; Craft, Brian (UC Santa Cruz Genomics Institute. University of California Santa Cruz) ; Piñeiro-Yáñez, Elena (Bioinformatics Unit. Spanish National Cancer Research Centre (CNIO)) ; Muñoz-Pomer Fuentes, Alfonso (European Molecular Biology Laboratory (EMBL). European Bioinformatics Institute (EMBL-EBI)) ; Petryszak, Robert (European Molecular Biology Laboratory (EMBL). European Bioinformatics Institute (EMBL-EBI)) ; Füllgrabe, Anja (European Molecular Biology Laboratory (EMBL). European Bioinformatics Institute (EMBL-EBI)) ; Al-Shahrour, Fatima (Bioinformatics Unit. Spanish National Cancer Research Centre (CNIO)) ; Keays, Maria (European Molecular Biology Laboratory (EMBL). European Bioinformatics Institute (EMBL-EBI)) ; Haussler, David (Howard Hughes Medical Institute. University of California Santa Cruz) ; Huber, Wolfgang (European Molecular Biology Laboratory (EMBL). Genome Biology Unit) ; Valencia, Alfonso (Institució Catalana de Recerca i Estudis Avançats) ; Papatheodorou, Irene (European Molecular Biology Laboratory (EMBL). European Bioinformatics Institute (EMBL-EBI)) ; Zhu, Jingchun (UC Santa Cruz Genomics Institute. University of California Santa Cruz) ; Fan, Yu (Department of Bioinformatics and Computational Biology. The University of Texas MD Anderson Cancer Center) ; Torrents, David (Institució Catalana de Recerca i Estudis Avançats) ; Bieg, Matthias (Heidelberg Center for Personalized Oncology (DKFZ-HIPO). German Cancer Research Center (DKFZ)) ; Chen, Ken (Department of Bioinformatics and Computational Biology. University of Texas MD Anderson Cancer Center) ; Chong, Zechen (Department of Genetics and Informatics Institute. University of Alabama at Birmingham) ; Cibulskis, Kristian (Broad Institute of MIT and Harvard) ; Eils, Roland (New BIH Digital Health Center. Berlin Institute of Health (BIH) and Charité-Universitätsmedizin Berlin) ; Fulton, Roberts S. (Department of Genetics and Department of Medicine. Washington University in St Louis) ; Gelpi, Josep Ll (Department of Biochemistry and Molecular Biomedicine. University of Barcelona) ; Gonzalez, Santiago (European Molecular Biology Laboratory (EMBL). Genome Biology Unit) ; Gut, Ivo (Centre de Regulació Genòmica) ; Hach, Faraz (Vancouver Prostate Centre) ; Heinold, Michael (Institute of Pharmacy and Molecular Biotechnology. and BioQuant. Heidelberg University) ; Hu, Taobo (Division of Life Science and Applied Genomics Center. Hong Kong University of Science and Technology) ; Huang, Vincent (Computational Biology Program. Ontario Institute for Cancer Research) ; Hutter, Barbara (National Center for Tumor Diseases (NCT) Heidelberg) ; Jäger, Natalie (Division of Theoretical Bioinformatics. German Cancer Research Center (DKFZ)) ; Jung, Jongsun (Genome Integration Data Center. Syntekabio) ; Kumar, Yogesh (Division of Life Science and Applied Genomics Center. Hong Kong University of Science and Technology) ; Lalansingh, Christopher (Computational Biology Program. Ontario Institute for Cancer Research) ; Leshchiner, Ignaty (Broad Institute of MIT and Harvard) ; Livitz, Dimitri (Broad Institute of MIT and Harvard) ; Ma, Eric Z. (Division of Life Science and Applied Genomics Center. Hong Kong University of Science and Technology) ; Maruvka, Yosef E. (Massachusetts General Hospital Center for Cancer Research) ; Milovanovic, Ana (Barcelona Supercomputing Center) ; Nielsen, Morten Muhlig (Department of Molecular Medicine (MOMA). Aarhus University Hospital) ; Paramasivam, Nagarajan (Heidelberg Center for Personalized Oncology (DKFZ-HIPO). German Cancer Research Center (DKFZ)) ; Pedersen, Jakob Skou (Bioinformatics Research Centre (BiRC). Aarhus University) ; Puiggròs, Montserrat (Barcelona Supercomputing Center) ; Sahinalp, S. Cenk (Simon Fraser University) ; Sarrafi, Iman (Simon Fraser University) ; Stewart, Chip (Broad Institute of MIT and Harvard) ; Stobbe, Miranda D. (CNAG-CRG. Centre for Genomic Regulation (CRG). Barcelona Institute of Science and Technology (BIST)) ; Wala, Jeremiah A. (Dana-Farber Cancer Institute) ; Wang, Jian (BGI-Shenzhen) ; Wendl, Michael (Department of Mathematics. Washington University in St Louis) ; Werner, Johannes (Department of Biological Oceanography. Leibniz Institute of Baltic Sea Research) ; Wu, Zhenggang (Division of Life Science and Applied Genomics Center. Hong Kong University of Science and Technology) ; Xue, Hong (Division of Life Science and Applied Genomics Center. Hong Kong University of Science and Technology) ; Yamaguchi, Takafum N. (Computational Biology Program. Ontario Institute for Cancer Research) ; Davis-Dusenbery, Brandi N. (Seven Bridges Genomics) ; Grossman, Robert L. (University of Chicago) ; Kim, Youngwook (Samsung Genome Institute) ; Heinold, Michael C. (Institute of Pharmacy and Molecular Biotechnology. and BioQuant. Heidelberg University) ; Hinton, Jonathan (Wellcome Trust Sanger Institute (Regne Unit)) ; Jones, David R. (Wellcome Trust Sanger Institute (Regne Unit)) ; Menzies, Andrew (Wellcome Trust Sanger Institute (Regne Unit)) ; Stebbings, Lucy (Wellcome Trust Sanger Institute (Regne Unit)) ; Hess, Julian M. (Massachusetts General Hospital Center for Cancer Research) ; Rosenberg, Mara (Massachusetts General Hospital (Boston)) ; Dunford, Andrew J. (Broad Institute of MIT and Harvard) ; Gupta, Manaswi (Broad Institute of MIT and Harvard) ; Imielinski, Marcin (Weill Cornell Medicine) ; Meyerson, Matthew (Dana-Farber Cancer Institute) ; Beroukhim, Rameen (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica). Department of Medical Oncology) ; Reimand, Jüri (Department of Medical Biophysics. University of Toronto) ; Dhingra, Priyanka (Institute for Computational Biomedicine. Weill Cornell Medicine) ; Favero, Francesco (Rigshospitalet) ; Dentro, Stefan (Wellcome Trust Sanger Institute (Regne Unit)) ; Rudneva, Vasilisa (European Molecular Biology Laboratory (EMBL). Genome Biology Unit) ; Park, Joong-Won (Center for Liver Cancer. Research Institute and Hospital. National Cancer Center) ; Hong, Eun Pyo (Department of Medical Genetics. College of Medicine. Hallym University) ; Heo, Seong Gu (Department of Medical Genetics. College of Medicine. Hallym University) ; Kahles, Andre (University Hospital Zurich) ; Lehmann, Kjong-Van (University Hospital Zurich) ; Soulette, Cameron M. (University of California Santa Cruz) ; Shiraishi, Yuichi (The Institute of Medical Science. The University of Tokyo) ; Liu, Fenglin (School of Life Sciences. Peking University) ; He, Yao (Peking University) ; Demircioğlu, Deniz (School of Computing. National University of Singapore) ; Davidson, Natalie R. (Department of Biology. ETH Zurich) ; Greger, Liliana (European Molecular Biology Laboratory (EMBL). European Bioinformatics Institute (EMBL-EBI)) ; Li, Siliang (China National GeneBank-Shenzhen) ; Liu, Dongbing (China National GeneBank-Shenzhen) ; Stark, Stefan G. (Korea University) ; Zhang, Fan (Peking University) ; Amin, Samirkumar B. (The Jackson Laboratory for Genomic Medicine) ; Bailey, Peter (Wolfson Wohl Cancer Research Centre. Institute of Cancer Sciences. University of Glasgow) ; Chateigner, Aurélien (Genome Informatics Program. Ontario Institute for Cancer Research) ; Frenkel-Morgenstern, Milana (The Azrieli Faculty of Medicine. Bar-Ilan University) ; Hou, Yong (China National GeneBank-Shenzhen) ; Huska, Matthew R. (Berlin Institute for Medical Systems Biology. Max Delbrück Center for Molecular Medicine) ; Kilpinen, Helena (University College London) ; Lamaze, Fabien C. (Computational Biology Program. Ontario Institute for Cancer Research) ; Li, Chang (China National GeneBank-Shenzhen) ; Li, Xiaobo (China National GeneBank-Shenzhen) ; Liu, Xingmin (China National GeneBank-Shenzhen) ; Marin, Maximillian G. (University of California Santa Cruz) ; Markowski, Julia (Berlin Institute for Medical Systems Biology. Max Delbrück Center for Molecular Medicine) ; Nandi, Tannistha (Genome Institute of Singapore) ; Ojesina, Akinyemi I. (O'Neal Comprehensive Cancer Center. University of Alabama at Birmingham) ; Pan-Hammarström, Qiang (Department of Biosciences and Nutrition. Karolinska Institutet) ; Park, Peter J. (Ludwig Center at Harvard Medical School) ; Pedamallu, Chandra Sekhar (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica). Department of Medical Oncology) ; Su, Hong (China National GeneBank-Shenzhen) ; Tan, Patrick (SingHealth. Duke-NUS Institute of Precision Medicine. National Heart Centre Singapore) ; Teh, Bin Tean (Laboratory of Cancer Epigenome. Division of Medical Science. National Cancer Centre Singapore) ; Wang, Jiayin (BGI-Shenzhen) ; Xiong, Heng (China National GeneBank-Shenzhen) ; Ye, Chen (China National GeneBank-Shenzhen) ; Yung, C. (Genome Informatics Program. Ontario Institute for Cancer Research) ; Zhang, Xiuqing (The University of Texas Health Science Center at Houston) ; Zheng, Liangtao (Peking University) ; Zhu, Shida (China National GeneBank-Shenzhen) ; Awadalla, Philip (Department of Molecular Genetics. University of Toronto) ; Creighton, Chad J. (Department of Medicine. Baylor College of Medicine) ; Wu, Kui (China National GeneBank-Shenzhen) ; Yang, Huanming (BGI-Shenzhen) ; Göke, Jonathan (National Cancer Centre Singapore) ; Zhang, Zemin (BIOPIC. ICG and College of Life Sciences. Peking University) ; Brooks, Angela N. (Dana-Farber Cancer Institute) ; Fittall, Matthew W. (The Francis Crick Institute) ; Martincorena, Iñigo (Wellcome Trust Sanger Institute (Regne Unit)) ; Rubio-Perez, Carlota (Vall d'Hebron Institute of Oncology (VHIO)) ; Juul, Malene (Department of Molecular Medicine (MOMA). Aarhus University Hospital) ; Schumacher, Steven (Department of Cancer Biology. Dana-Farber Cancer Institute) ; Shapira, Ofer (Dana-Farber Cancer Institute) ; Tamborero, David (Universitat Pompeu Fabra. Unitat de Recerca en Informàtica Biomèdica (GRIB)) ; Mularoni, Loris (Universitat Pompeu Fabra. Unitat de Recerca en Informàtica Biomèdica (GRIB)) ; Hornshøj, Henrik (Department of Molecular Medicine (MOMA). Aarhus University Hospital) ; Deu-Pons, Jordi (Institute for Research in Biomedicine (IRB Barcelona). The Barcelona Institute of Science and Technology (BIST)) ; Muiños, Ferran (Universitat Pompeu Fabra. Unitat de Recerca en Informàtica Biomèdica (GRIB)) ; Bertl, Johanna (Department of Mathematics. Aarhus University) ; Guo, Qianyun (Bioinformatics Research Centre (BiRC). Aarhus University) ; González-Pérez, Abel (Institut Hospital del Mar d'Investigacions Mèdiques) ; Bazant, Wojciech (European Molecular Biology Laboratory (EMBL). European Bioinformatics Institute (EMBL-EBI)) ; Barrera, Elisabet (European Molecular Biology Laboratory (EMBL). European Bioinformatics Institute (EMBL-EBI)) ; Al-Sedairy, Sultan T. (King Faisal Specialist Hospital and Research Centre) ; Aretz, Axel (DLR Project Management Agency) ; Bell, Cindy (Genome Canada) ; Betancourt, Miguel (Instituto Carlos Slim de la Salud) ; Buchholz, Christiane (Federal Ministry of Education and Research) ; Calvo, Fabien (Institut Gustave Roussy) ; Chomienne, Christine (Institut National du Cancer (INCA)) ; Dunn, Michael (The Wellcome Trust) ; Edmonds, Stuart (Prostate Cancer Canada) ; Green, Eric (National Human Genome Research Institute. National Institutes of Health) ; Gupta, Shailja (Department of Biotechnology. Ministry of Science & Technology. Government of India. New Delhi) ; Hutter, Carolyn M. (National Human Genome Research Institute. National Institutes of Health) ; Jegalian, Karine (Science Writer) ; Jones, Nic (Cancer Research UK) ; Lu, Youyong (Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education). Peking University Cancer Hospital & Institute) ; Nakagama, Hitoshi (National Cancer Center) ; Nettekoven, Gerd (German Cancer Aid) ; Planko, Laura (German Cancer Aid) ; Scott, David (Cancer Research UK) ; Shibata, Tatsuhiro (Laboratory of Molecular Medicine. Human Genome Center. The Institute of Medical Science. The University of Tokyo) ; Shimizu, Kiyo (Japan Agency for Medical Research and Development) ; Stratton, Michael R. (Wellcome Trust Sanger Institute (Regne Unit)) ; Yugawa, Takashi (Japan Agency for Medical Research and Development) ; Tortora, Giampaolo (University of Verona) ; VijayRaghavan, K. (Department of Biotechnology. Ministry of Science & Technology. Government of India. New Delhi) ; Zenklusen, Jean C. (National Cancer Institute. National Institutes of Health) ; Townend, David (CAPHRI Research School. Maastricht University) ; Knoppers, Bartha M. (Centre of Genomics and Policy. McGill University and Génome Québec Innovation Centre. Montreal) ; Aminou, Brice (Genome Informatics Program. Ontario Institute for Cancer Research) ; Bartolome, Javier (Barcelona Supercomputing Center) ; Boroevich, Keith A. (Laboratory for Medical Science Mathematics. RIKEN Center for Integrative Medical Sciences) ; Boyce, Rich (European Molecular Biology Laboratory (EMBL). European Bioinformatics Institute (EMBL-EBI)) ; Buchanan, Alex (Computational Biology Program. Oregon Health & Science University) ; Byrne, Niall J. (Genome Informatics Program. Ontario Institute for Cancer Research) ; Chen, Zhaohong (University of California San Diego) ; Cho, Sunghoon (PDXen Biosystems) ; Choi, Wan (Electronics and Telecommunications Research Institute) ; Clapham, Peter (Wellcome Trust Sanger Institute (Regne Unit)) ; Dow, Michelle T. (University of California San Diego) ; Dursi, Lewis Jonathan (The Hospital for Sick Children) ; Eils, Juergen (New BIH Digital Health Center. Berlin Institute of Health (BIH) and Charité-Universitätsmedizin Berlin) ; Farcas, Claudiu (University of California San Diego) ; Fayzullaev, Nodirjon (Genome Informatics Program. Ontario Institute for Cancer Research) ; Flicek, Paul (European Molecular Biology Laboratory (EMBL). European Bioinformatics Institute (EMBL-EBI)) ; Heath, Allison P. (Children's Hospital of Philadelphia) ; Hofmann, Oliver (University of Melbourne Centre for Cancer Research) ; Hong, Jongwhi H. (Syntekabio) ; Hudson, Thomas J. (Genomics Research Program. Ontario Institute for Cancer Research) ; Hübschmann, Daniel (Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM)) ; Ivkovic, Sinisa (Seven Bridges) ; Jeon, Seung-Hyup (Electronics and Telecommunications Research Institute) ; Jiao, Wei (Computational Biology Program. Ontario Institute for Cancer Research) ; Kabbe, Rolf (Division of Theoretical Bioinformatics. German Cancer Research Center (DKFZ)) ; Kahles, Andre (University Hospital Zurich) ; Kerssemakers, Jules N. A. (Division of Theoretical Bioinformatics. German Cancer Research Center (DKFZ)) ; Kim, Hyunghwan (Electronics and Telecommunications Research Institute) ; Kim, Jaegil (Health Sciences Department of Biomedical Informatics. University of California San Diego) ; Koscher, Michael (Functional and Structural Genomics. German Cancer Research Center (DKFZ)) ; Koures, Antonios (University of California San Diego) ; Kovacevic, Milena (Seven Bridges) ; Lawerenz, Chris (New BIH Digital Health Center. Berlin Institute of Health (BIH) and Charité-Universitätsmedizin Berlin) ; Liu, Jia (Leidos Biomedical Research) ; Mijalkovic, Sanja (Seven Bridges) ; Mijalkovic-Lazic, Anna (Seven Bridges) ; Miyano, Satoru (The Institute of Medical Science. The University of Tokyo) ; Nastic, Mia (Seven Bridges) ; Nicholson, Jonathan (Wellcome Trust Sanger Institute (Regne Unit)) ; Ocana, David (European Molecular Biology Laboratory (EMBL). European Bioinformatics Institute (EMBL-EBI)) ; Ohi, Kazuhiro (The Institute of Medical Science. The University of Tokyo) ; Ohno-Machado, Lucila (University of California San Diego) ; Pihl, Todd D. (CSRA Incorporated) ; Prinz, Manuel (Division of Theoretical Bioinformatics. German Cancer Research Center (DKFZ)) ; Radovic, Petar (Seven Bridges) ; Short, Charles (European Molecular Biology Laboratory (EMBL). European Bioinformatics Institute (EMBL-EBI)) ; Sofia, Heidi J. (National Human Genome Research Institute. National Institutes of Health) ; Spring, Jonathan (University of Chicago) ; Struck, Adam J. (Computational Biology Program. Oregon Health & Science University) ; Tijanic, Nebojsa (Seven Bridges) ; Vicente, David (Barcelona Supercomputing Center) ; Wang, Zhining (National Cancer Institute. National Institutes of Health) ; Williams, Ashley (University of California San Diego) ; Woo, Youngchoon (Electronics and Telecommunications Research Institute) ; Wright, Adam J. (Computational Biology Program. Ontario Institute for Cancer Research) ; Yang, Liming (National Cancer Institute, National Institutes of Health, Bethesda) ; Hamilton, Mark P. (Department of Internal Medicine. Stanford University) ; Johnson, Todd Andrew (Laboratory for Medical Science Mathematics. RIKEN Center for Integrative Medical Sciences) ; Kahraman, Abdullah (Institute of Molecular Life Sciences. University of Zurich) ; Kellis, Manolis (MIT Computer Science and Artificial Intelligence Laboratory. Massachusetts Institute of Technology) ; Polak, Paz (Harvard Medical School) ; Sallari, Richard (Broad Institute of MIT and Harvard) ; Sinnott-Armstrong, Nasa (Department of Genetics. Stanford University School of Medicine) ; von Mering, Christian (Institute of Molecular Life Sciences and Swiss Institute of Bioinformatics. University of Zurich) ; Beltran, Sergi (CNAG-CRG. Centre for Genomic Regulation (CRG). Barcelona Institute of Science and Technology (BIST)) ; Gerhard, Daniela S. (Office of Cancer Genomics. National Cancer Institute. National Institutes of Health) ; Gut, Marta (Centre Nacional d'Anàlisi Genòmica) ; Trotta, Jean-Rémi (CNAG-CRG. Centre for Genomic Regulation (CRG). Barcelona Institute of Science and Technology (BIST)) ; Whalley, Justin P. (CNAG-CRG. Centre for Genomic Regulation (CRG). Barcelona Institute of Science and Technology (BIST)) ; Niu, Beifang (Computer Network Information Center. Chinese Academy of Sciences) ; Espiritu, Shadrielle M. G. (Computational Biology Program. Ontario Institute for Cancer Research) ; Gao, Shengjie (BGI-Shenzhen) ; Huang, Yi (Geneplus-Shenzhen) ; Lalansingh, Christopher M. (Computational Biology Program. Ontario Institute for Cancer Research) ; Teague, Jon W. (Wellcome Trust Sanger Institute (Regne Unit)) ; Wendl, Michael C. (Department of Mathematics. Washington University in St Louis) ; Abascal, Federico (Wellcome Trust Sanger Institute (Regne Unit)) ; Bader, Gary D. (Department of Molecular Genetics. University of Toronto) ; Bandopadhayay, Pratiti (Department of Pediatrics. Harvard Medical School) ; Barenboim, Jonathan (Computational Biology Program. Ontario Institute for Cancer Research) ; Brunak, Søren (University of Copenhagen) ; Carlevaro-Fita, Joana (Graduate School for Cellular and Biomedical Sciences. University of Bern) ; Chakravarty, Dimple (Department of Urology. Icahn School of Medicine at Mount Sinai) ; Chan, Calvin Wing Yiu (Faculty of Biosciences. Heidelberg University) ; Choi, Jung Kyoon (Korea Advanced Institute of Science and Technology) ; Diamanti, Klev (Science for Life Laboratory. Department of Cell and Molecular Biology. Uppsala University) ; Fink, Lynn L. (Queensland Centre for Medical Genomics. Institute for Molecular Bioscience. The University of Queensland) ; Frigola, Joan (Institute for Research in Biomedicine (IRB Barcelona). The Barcelona Institute of Science and Technology (BIST)) ; Gambacorti-Passerini, Carlo (University of Milano Bicocca) ; Garsed, Dale W. (Sir Peter MacCallum Department of Oncology. Peter MacCallum Cancer Centre. University of Melbourne) ; Haradhvala, Nicholas J. (Massachusetts General Hospital (Boston)) ; Harmanci, Arif O. (Center for Precision Health. School of Biomedical Informatics. The University of Texas Health Science Center) ; Helmy, Mohamed (The Donnelly Centre. University of Toronto) ; Herrmann, Carl (Health Data Science Unit. University Clinics) ; Hobolth, Asger (Department of Mathematics. Aarhus University) ; Hodzic, Ermin (Simon Fraser University) ; Hong, Chen (Faculty of Biosciences. Heidelberg University) ; Isaev, Keren (Department of Medical Biophysics. University of Toronto) ; Izarzugaza, Jose M. G. (Technical University of Denmark) ; Johnson, Rory (Department for Biomedical Research. University of Bern) ; Juul, Randi Istrup (Department of Molecular Medicine (MOMA). Aarhus University Hospital) ; Kim, Jihoon (Health Sciences Department of Biomedical Informatics. University of California San Diego) ; Kim, Jong K. (Research Core Center. National Cancer Centre Korea) ; Jan Komorowski, None (Institute of Computer Science. Polish Academy of Sciences) ; Lanzós, Andrés (Department for Biomedical Research. University of Bern) ; Larsson, Erik (Memorial Sloan Kettering Cancer Center) ; Lee, Donghoon (Canada's Michael Smith Genome Sciences Center. BC Cancer Agency) ; Li, Shantao (China National GeneBank-Shenzhen) ; Li, Xiaobo (China National GeneBank-Shenzhen) ; Lin, Ziao (Harvard University) ; Liu, Eric Minwei (Memorial Sloan Kettering Cancer Center) ; Lochovsky, Lucas (The Jackson Laboratory for Genomic Medicine) ; Lou, Shaoke (Program in Computational Biology and Bioinformatics. Yale University) ; Madsen, Tobias (Department of Molecular Medicine (MOMA). Aarhus University Hospital) ; Marchal, Kathleen (Department of Plant Biotechnology and Bioinformatics. Ghent University) ; Martinez-Fundichely, Alexander (Institute for Computational Biomedicine. Weill Cornell Medicine) ; McGillivray, Patrick D. (Department of Molecular Biophysics and Biochemistry. Yale University) ; Meyerson, William (Yale School of Medicine. Yale University) ; Paczkowska, Marta (Computational Biology Program. Ontario Institute for Cancer Research) ; Park, Kiejung (Cheonan Industry-Academic Collaboration Foundation. Sangmyung University) ; Pons, Tirso (Spanish National Cancer Research Centre) ; Pulido-Tamayo, Sergio (Department of Plant Biotechnology and Bioinformatics. Ghent University) ; Reyes-Salazar, Iker (Institute for Research in Biomedicine (IRB Barcelona)) ; Reyna, Matthew A. (Department of Computer Science. Princeton University) ; Rubin, Mark A. (Pathology and Laboratory. Weill Cornell Medical College) ; Salichos, Leonidas (Program in Computational Biology and Bioinformatics. Yale University) ; Sander, Chris (Department of Cell Biology. Harvard Medical School) ; Schumacher, Steven E. (Department of Cancer Biology. Dana-Farber Cancer Institute) ; Shackleton, Mark (Sir Peter MacCallum Department of Oncology. Peter MacCallum Cancer Centre. University of Melbourne) ; Shen, Ciyue (cBio Center. Dana-Farber Cancer Institute) ; Shrestha, Raunak (Vancouver Prostate Centre) ; Shuai, Shimin (Department of Molecular Genetics. University of Toronto) ; Tsunoda, Tatsuhiko (Laboratory for Medical Science Mathematics. Department of Biological Sciences. Graduate School of Science. The University of Tokyo) ; Umer, Husen M. (Science for Life Laboratory. Department of Oncology-Pathology. Karolinska Institutet) ; Uusküla-Reimand, Liis (Genetics & Genome Biology Program. SickKids Research Institute. The Hospital for Sick Children) ; Verbeke, Lieven P. C. (Department of Information Technology. Ghent University. Interuniversitair Micro-Electronica Centrum (IMEC)) ; Wadelius, Claes (Science for Life Laboratory. Department of Immunology. Genetics and Pathology. Uppsala University) ; Wadi, Lina (Computational Biology Program. Ontario Institute for Cancer Research) ; Warrell, Jonathan (Program in Computational Biology and Bioinformatics. Yale University) ; Wu, Guanming (Oregon Health & Sciences University) ; Yu, Jun (Department of Medicine and Therapeutics. The Chinese University of Hong Kong) ; Zhang, Jing (National Cancer Institute. National Institutes of Health) ; Zhang, Xuanping (The University of Texas Health Science Center at Houston) ; Zhang, Yan (The Ohio State University Comprehensive Cancer Center (OSUCCC - James)) ; Zhao, Zhongming (The University of Texas School of Biomedical Informatics (SBMI) at Houston) ; Zou, Lihua (Department of Biochemistry and Molecular Genetics. Feinberg School of Medicine. Northwestern University) ; Lawrence, Michael S. (Laboratory for Medical Science Mathematics. RIKEN Center for Integrative Medical Sciences) ; Raphael, Benjamin J. (Department of Computer Science. Princeton University) ; Bailey, Peter J. (Wolfson Wohl Cancer Research Centre. Institute of Cancer Sciences. University of Glasgow) ; Craft, David (Physics Division. Optimization and Systems Biology Lab. Massachusetts General Hospital) ; Goldman, Mary J. (UC Santa Cruz Genomics Institute. University of California Santa Cruz) ; Aburatani, Hiroyuki (Genome Science Division. Research Center for Advanced Science and Technology. The University of Tokyo) ; Binder, Hans (Interdisciplinary Center for Bioinformatics. University of Leipzig) ; Dinh, Huy Q. (Center for Bioinformatics and Functional Genomics. Cedars-Sinai Medical Center) ; Heath, Simon C. (CNAG-CRG. Centre for Genomic Regulation (CRG). Barcelona Institute of Science and Technology (BIST)) ; Hoffmann, Steve (Transcriptome Bioinformatics. LIFE Research Center for Civilization Diseases. University of Leipzig) ; Imbusch, Charles David (Division of Applied Bioinformatics. German Cancer Research Center (DKFZ)) ; Kretzmer, Helene (Transcriptome Bioinformatics. LIFE Research Center for Civilization Diseases. University of Leipzig) ; Laird, Peter W. (Center for Epigenetics. Van Andel Research Institute) ; Martin-Subero, Jose Ignacio (Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ; Nagae, Genta (Research Center for Advanced Science and Technology. The University of Tokyo) ; Shen, Hui (Van Andel Research Institute) ; Wang, Qi (Functional and Structural Genomics. German Cancer Research Center (DKFZ)) ; Weichenhan, Dieter (Cancer Epigenomics. German Cancer Research Center (DKFZ)) ; Zhou, Wanding (Van Andel Research Institute) ; Berman, Benjamin P. (The Hebrew University Faculty of Medicine) ; Brors, Benedikt (German Cancer Consortium (DKTK). German Cancer Research Center (DKFZ)) ; Plass, Christoph (Cancer Epigenomics. German Cancer Research Center (DKFZ)) ; Akdemir, Kadir C. (Department of Bioinformatics and Computational Biology. University of Texas MD Anderson Cancer Center) ; Bowtell, David D. L. (Sir Peter MacCallum Department of Oncology. Peter MacCallum Cancer Centre. University of Melbourne) ; Burns, Kathleen H. (McKusick-Nathans Institute of Genetic Medicine. Sidney Kimmel Comprehensive Cancer Center. Johns Hopkins University School of Medicine) ; Busanovich, Jhon (Foundation Medicine) ; Chan, Kin (Department of Biochemistry. Microbiology and Immunology. Faculty of Medicine. University of Ottawa) ; Dueso-Barroso, Ana (Barcelona Supercomputing Center) ; Edwards, Paul A. (University of Cambridge) ; Etemadmoghadam, Dariush (Sir Peter MacCallum Department of Oncology. Peter MacCallum Cancer Centre. University of Melbourne) ; Haber, James E. (Brandeis University) ; Jones, David T. W. (Pediatric Glioma Research Group. German Cancer Research Center (DKFZ)) ; Ju, Young Seok (Wellcome Trust Sanger Institute (Regne Unit)) ; Kazanov, Marat D. (Skolkovo Institute of Science and Technology) ; Koh, Youngil (Department of Internal Medicine. Seoul National University Hospital) ; Kumar, Kiran (Broad Institute of MIT and Harvard) ; Lee, Eunjung Alice (Division of Genetics and Genomics. Boston Children's Hospital. Harvard Medical School) ; Lee, Jake June-Koo (Ludwig Center at Harvard Medical School) ; Lynch, Andy Graeme (School of Medicine/School of Mathematics and Statistics. University of St Andrews) ; Macintyre, Geoff (Cancer Research UK Cambridge Institute. University of Cambridge) ; Markowetz, Florian (University of Cambridge) ; Navarro, Fabio C. P. (Department of Molecular Biophysics and Biochemistry. Yale University) ; Pearson, John V. (Institute for Molecular Bioscience. University of Queensland) ; Rippe, Karsten (German Cancer Research Center (DKFZ)) ; Scully, Ralph (Cancer Research Institute. Beth Israel Deaconess Medical Center) ; Villasante, Izar (Barcelona Supercomputing Center) ; Waddell, Nicola (Institute for Molecular Bioscience. University of Queensland) ; Yang, Lixing (Ben May Department for Cancer Research. Department of Human Genetics. The University of Chicago) ; Yao, Xiaotong (Tri-Institutional PhD Program in Computational Biology and Medicine. Weill Cornell Medicine) ; Yoon, Sung-Soo (Department of Internal Medicine. Seoul National University Hospital) ; Zhang, Cheng-Zhong (Dana-Farber Cancer Institute) ; Bergstrom, Erik N. (Department of Bioengineering. and Department of Cellular and Molecular Medicine. Moores Cancer Center. University of California. San Diego) ; Boot, Arnoud (Centre for Computational Biology. Duke-NUS Medical School) ; Covington, Kyle (Human Genome Sequencing Center. Baylor College of Medicine) ; Fujimoto, Akihiro (RIKEN Center for Integrative Medical Sciences) ; Huang, Mi Ni (Centre for Computational Biology. Duke-NUS Medical School) ; Islam, S. M. Ashiqul (Department of Bioengineering and Department of Cellular and Molecular Medicine. Moores Cancer Center. University of California San Diego) ; McPherson, John R. (Centre for Computational Biology. Duke-NUS Medical School) ; Morganella, S. (Wellcome Trust Sanger Institute (Regne Unit)) ; Mustonen, Ville (Organismal and Evolutionary Biology Research Programme. University of Helsinki) ; Ng, Alvin Wei Tian (Programme in Cancer & Stem Cell Biology. Centre for Computational Biology. Duke-NUS Medical School) ; Prokopec, Stephenie D. (Computational Biology Program. Ontario Institute for Cancer Research) ; Vázquez-García, Ignacio (Wellcome Trust Sanger Institute (Regne Unit)) ; Wu, Yang (Centre for Computational Biology. Duke-NUS Medical School) ; Yousif, Fouad (Computational Biology Program. Ontario Institute for Cancer Research) ; Yu, Willie (Duke-NUS Medical School) ; Rozen, Steven G. (Centre for Computational Biology. Duke-NUS Medical School) ; Rudneva, Vasilisa A. (European Molecular Biology Laboratory (EMBL). Genome Biology Unit) ; Shringarpure, Suyash S. (Department of Genetics. Stanford University School of Medicine) ; Turner, Daniel J. (Applications Department. Oxford Nanopore Technologies) ; Xia, Tian (School of Electronic Information and Communications. Huazhong University of Science and Technology) ; Atwal, Gurnit (Vector Institute) ; Chang, David K. (The Kinghorn Cancer Centre. Cancer Division. Garvan Institute of Medical Research. University of New South Wales) ; Cooke, Susanna L. (Wolfson Wohl Cancer Research Centre. Institute of Cancer Sciences. University of Glasgow) ; Faltas, Bishoy M. (Weill Cornell Medical College) ; Haider, Syed (Computational Biology Program. Ontario Institute for Cancer Research) ; Kaiser, Vera B. (MRC Human Genetics Unit. MRC IGMM. University of Edinburgh) ; Karlić, Rosa (Bioinformatics Group. Division of Molecular Biology. Department of Biology. Faculty of Science. University of Zagreb) ; Kato, Mamoru (Department of Bioinformatics. Division of Cancer Genomics. National Cancer Center Research Institute. National Cancer Center) ; Kübler, Kirsten (Massachusetts General Hospital (Boston)) ; Margolin, Adam (Computational Biology Program. Oregon Health & Science University) ; Martin, Sancha (Wellcome Trust Sanger Institute (Regne Unit)) ; Nik-Zainal, Serena (Wellcome Trust Sanger Institute (Regne Unit)) ; P'ng, Christine (Computational Biology Program. Ontario Institute for Cancer Research) ; Semple, Colin A. (MRC Human Genetics Unit. MRC IGMM. University of Edinburgh) ; Smith, Jaclyn (Computational Biology Program. Oregon Health & Science University) ; Sun, Ren X. (Computational Biology Program. Ontario Institute for Cancer Research) ; Thai, Kevin (Genome Informatics Program. Ontario Institute for Cancer Research) ; Wright, Derek W. (Wolfson Wohl Cancer Research Centre. Institute of Cancer Sciences. University of Glasgow) ; Yuan, Ke (School of Computing Science. University of Glasgow) ; Biankin, Andrew V. (West of Scotland Pancreatic Unit. Glasgow Royal Infirmary) ; Garraway, Levi (Dana-Farber Cancer Institute) ; Grimmond, Sean M. (University of Melbourne Centre for Cancer Research) ; Adams, David J. (Wellcome Trust Sanger Institute (Regne Unit)) ; Anur, Pavana (Molecular and Medical Genetics. Oregon Health & Science University) ; Cao, Shaolong (Department of Bioinformatics and Computational Biology. The University of Texas MD Anderson Cancer Center) ; Christie, Elizabeth L. (Sir Peter MacCallum Department of Oncology. Peter MacCallum Cancer Centre. University of Melbourne) ; Cmero, Marek (Walter + Eliza Hall Institute) ; Cun, Yupeng (University of Cologne) ; Dawson, Kevin J. (Wellcome Trust Sanger Institute (Regne Unit)) ; Dentro, Stefan (Wellcome Trust Sanger Institute (Regne Unit)) ; Deshwar, Amit G. (The Edward S. Rogers Sr Department of Electrical and Computer Engineering. University of Toronto) ; Donmez, Nilgun (Simon Fraser University) ; Drews, Ruben M. (Cancer Research UK Cambridge Institute. University of Cambridge) ; Gerstung, Moritz (European Molecular Biology Laboratory (EMBL). Genome Biology Unit) ; Ha, Gavin (Broad Institute of MIT and Harvard) ; Haase, Kerstin (The Francis Crick Institute) ; Jerman, Lara (University of Ljubljana) ; Ji, Yuan (Research Institute. NorthShore University HealthSystem) ; Jolly, Clemency (The Francis Crick Institute) ; Lee, Juhee (Department of Statistics. University of California Santa Cruz) ; Lee-Six, Henry (Wellcome Trust Sanger Institute (Regne Unit)) ; Malikic, Salem (Simon Fraser University) ; Mitchell, Thomas J. (Wellcome Trust Sanger Institute (Regne Unit)) ; Morris, Quaid D. (University of Toronto) ; Oesper, Layla (Department of Computer Science. Carleton College) ; Peifer, Martin (University of Cologne) ; Peto, Myron (Molecular and Medical Genetics. Oregon Health & Science University) ; Rosebrock, Daniel (Broad Institute of MIT and Harvard) ; Rubanova, Yulia (Vector Institute) ; Salcedo, Adriana (Computational Biology Program. Ontario Institute for Cancer Research) ; Sengupta, Subhajit (Center for Psychiatric Genetics. NorthShore University HealthSystem) ; Shi, Ruian (University of Toronto) ; Shin, Seung Jun. (Korea University) ; Spiro, Oliver (Broad Institute of MIT and Harvard) ; Vembu, Shankar (Argmix Consulting) ; Wintersinger, Jeffrey A. (Vector Institute) ; Yang, Tsun-Po (University of Cologne) ; Yu, Kaixian (Department of Biostatistics. The University of Texas MD Anderson Cancer Center) ; Zhu, Hongtu (The University of Texas MD Anderson Cancer Center) ; Spellman, Paul T. (Molecular and Medical Genetics. Knight Cancer Institute. Oregon Health & Science University) ; Weinstein, John N. (Department of Bioinformatics and Computational Biology and Department of Systems Biology. The University of Texas MD Anderson Cancer Center) ; Chen, Yiwen (Department of Bioinformatics and Computational Biology. The University of Texas MD Anderson Cancer Center) ; Fujita, Masashi (RIKEN Center for Integrative Medical Sciences) ; Han, Leng (The University of Texas Health Science Center at Houston) ; Hasegawa, Takanori (The Institute of Medical Science. The University of Tokyo) ; Komura, Mitsuhiro (The Institute of Medical Science. The University of Tokyo) ; Li, Jun (Department of Bioinformatics and Computational Biology. The University of Texas MD Anderson Cancer Center) ; Mizuno, Shinichi (Department of Health Sciences. Faculty of Medical Sciences. Kyushu University) ; Shimizu, Eigo (The Institute of Medical Science. The University of Tokyo) ; Wang, Yumeng (Baylor College of Medicine) ; Xu, Yanxun (Department of Applied Mathematics and Statistics. Johns Hopkins University) ; Yamaguchi, Rui (The Institute of Medical Science. The University of Tokyo) ; Yang, Fan (University of Toronto) ; Yang, Yang (The University of Texas Health Science Center at Houston) ; Yoon, Christophe J. (Korea Advanced Institute of Science and Technology) ; Yuan, Yuan (Department of Bioinformatics and Computational Biology. The University of Texas MD Anderson Cancer Center) ; Liang, Han (Department of Bioinformatics and Computational Biology. The University of Texas MD Anderson Cancer Center) ; Alawi, Malik (University Medical Center Hamburg-Eppendorf. Bioinformatics Core) ; Borozan, Ivan (Computational Biology Program. Ontario Institute for Cancer Research) ; Brewer, Daniel S. (Norwich Medical School. University of East Anglia) ; Cooper, Colin S. (University of East Anglia) ; Desai, Nikita (Genome Informatics Program. Ontario Institute for Cancer Research) ; Grundhoff, Adam (German Center for Infection Research (DZIF). Partner Site Hamburg-Borstel-Lübeck-Riems) ; Iskar, Murat (Division of Molecular Genetics. German Cancer Research Center (DKFZ)) ; Su, Xiaoping (Department of Pathology. The University of Texas MD Anderson Cancer Center) ; Zapatka, Marc (Division of Molecular Genetics. German Cancer Research Center (DKFZ)) ; Lichter, Peter (Division of Molecular Genetics. German Cancer Research Center (DKFZ)) ; Alsop, Kathryn (Sir Peter MacCallum Department of Oncology. Peter MacCallum Cancer Centre. University of Melbourne) ; Bruxner, Timothy J. C. (Queensland Centre for Medical Genomics. Institute for Molecular Bioscience. The University of Queensland) ; Christ, Angelika N. (Queensland Centre for Medical Genomics. Institute for Molecular Bioscience. The University of Queensland) ; Cordner, Stephen M. (Victorian Institute of Forensic Medicine) ; Cowin, Prue A. (Peter MacCallum Cancer Centre. University of Melbourne) ; Drapkin, Ronny (University of Pennsylvania) ; Fereday, Sian (Peter MacCallum Cancer Centre. University of Melbourne) ; George, Joshy (The Jackson Laboratory for Genomic Medicine) ; Hamilton, Anne (Peter MacCallum Cancer Centre. University of Melbourne) ; Holmes, Oliver (Institute for Molecular Bioscience. University of Queensland) ; Hung, Jillian (Department of Gynaecological Oncology. Westmead Hospital) ; Kassahn, Karin S. (Genetics and Molecular Pathology. SA Pathology) ; Kazakoff, Stephen H. (Institute for Molecular Bioscience. University of Queensland) ; Kennedy, Catherine J. (Department of Gynaecological Oncology. Westmead Hospital) ; Leonard, Conrad R. (Institute for Molecular Bioscience. University of Queensland) ; Mileshkin, Linda (Sir Peter MacCallum Department of Oncology. Peter MacCallum Cancer Centre. University of Melbourne) ; Miller, David K. (Garvan Institute of Medical Research) ; Arnau, Gisela Mir (Peter MacCallum Cancer Centre. University of Melbourne) ; Mitchell, Chris (Peter MacCallum Cancer Centre. University of Melbourne) ; Newell, Felicity (Institute for Molecular Bioscience. University of Queensland) ; Nones, Katia (Institute for Molecular Bioscience. University of Queensland) ; Patch, Ann-Marie (Institute for Molecular Bioscience. University of Queensland) ; Quinn, Michael C. (Institute for Molecular Bioscience. University of Queensland) ; Taylor, Darrin F. (Queensland Centre for Medical Genomics. Institute for Molecular Bioscience. The University of Queensland) ; Thorne, Heather (Peter MacCallum Cancer Centre. University of Melbourne) ; Traficante, Nadia (Peter MacCallum Cancer Centre. University of Melbourne) ; Vedururu, Ravikiran (Peter MacCallum Cancer Centre. University of Melbourne) ; Waddell, Nick M. (Institute for Molecular Bioscience. University of Queensland) ; Waring, Paul M. (Department of Clinical Pathology. University of Melbourne) ; Wood, Scott (Institute for Molecular Bioscience. University of Queensland) ; Xu, Qinying (Institute for Molecular Bioscience. University of Queensland) ; deFazio, Anna (Westmead Clinical School. The Westmead Institute for Medical Research) ; Anderson, Matthew J. (Queensland Centre for Medical Genomics. Institute for Molecular Bioscience. The University of Queensland) ; Antonello, Davide (University Hospital of Verona (Itàlia)) ; Barbour, Andrew P. (Surgical Oncology Group. Diamantina Institute. The University of Queensland) ; Bassi, Claudio (University Hospital of Verona (Itàlia)) ; Bersani, Samantha (Department of Diagnostics and Public Health. University and Hospital Trust of Verona) ; Cataldo, Ivana (University and Hospital Trust of Verona. ARC-Net Centre for Applied Research on Cancer) ; Chantrill, Lorraine A. (Illawarra Shoalhaven Local Health District L3 Illawarra Cancer Care Centre. Wollongong Hospital) ; Chiew, Yoke-Eng (Centre for Cancer Research. The Westmead Institute for Medical Research. The University of Sydney) ; Chou, Angela (Department of Pathology. University of Sydney) ; Cingarlini, Sara (Medical Oncology. University and Hospital Trust of Verona) ; Cloonan, Nicole (School of Biological Sciences. The University of Auckland) ; Corbo, Vincenzo (Department of Pathology and Diagnostics. University and Hospital Trust of Verona) ; Davi, Maria Vittoria (Department of Medicine. Section of Endocrinology. University and Hospital Trust of Verona) ; Duthie, Fraser R. (Department of Pathology. Queen Elizabeth University Hospital) ; Gill, Anthony J. (Department of Pathology. University of Sydney) ; Graham, Janet S. (Department of Medical Oncology. Beatson West of Scotland Cancer Centre) ; Harliwong, Ivon (Queensland Centre for Medical Genomics. Institute for Molecular Bioscience. The University of Queensland) ; Jamieson, Nigel B. (Academic Unit of Surgery. School of Medicine. College of Medical. Veterinary and Life Sciences. University of Glasgow. Glasgow Royal Infirmary) ; Johns, Amber L. (Garvan Institute of Medical Research) ; Kench, James G. (Tissue Pathology and Diagnostic Oncology. Royal Prince Alfred Hospital) ; Landoni, Luca (University Hospital of Verona (Itàlia)) ; Lawlor, Rita T. (University and Hospital Trust of Verona. ARC-Net Centre for Applied Research on Cancer) ; Mafficini, Andrea (University and Hospital Trust of Verona. ARC-Net Centre for Applied Research on Cancer) ; Merrett, Neil D. (Discipline of Surgery. Western Sydney University) ; Miotto, Marco (University Hospital of Verona (Itàlia)) ; Musgrove, Elizabeth A. (Wolfson Wohl Cancer Research Centre. Institute of Cancer Sciences. University of Glasgow) ; Nagrial, A. M. (The Kinghorn Cancer Centre. Cancer Division. Garvan Institute of Medical Research. University of New South Wales) ; Oien, Karin A. (Institute of Cancer Sciences. College of Medical Veterinary and Life Sciences. University of Glasgow) ; Pajic, Marina (The Kinghorn Cancer Centre. Cancer Division. Garvan Institute of Medical Research. University of New South Wales) ; Pinese, Mark (The Kinghorn Cancer Centre. Cancer Division. Garvan Institute of Medical Research. University of New South Wales) ; Robertson, Alan J. (Queensland Centre for Medical Genomics. Institute for Molecular Bioscience. The University of Queensland) ; Rooman, Ilse (The Kinghorn Cancer Centre. Cancer Division. Garvan Institute of Medical Research. University of New South Wales) ; Rusev, Borislav C. (University and Hospital Trust of Verona. ARC-Net Centre for Applied Research on Cancer) ; Samra, Jaswinder S. (Department of Pathology. University of Sydney) ; Scardoni, Maria (Department of Diagnostics and Public Health. University and Hospital Trust of Verona) ; Scarlett, Christopher J. (School of Environmental and Life Sciences. Faculty of Science. The University of Newcastle) ; Scarpa, Aldo (University and Hospital Trust of Verona. ARC-Net Centre for Applied Research on Cancer) ; Sereni, Elisabetta (University Hospital of Verona (Itàlia)) ; Sikora, Katarzyna O. (University and Hospital Trust of Verona. ARC-Net Centre for Applied Research on Cancer) ; Simbolo, Michele (Department of Pathology and Diagnostics. University and Hospital Trust of Verona) ; Taschuk, Morgan L. (Genome Informatics Program. Ontario Institute for Cancer Research) ; Toon, Christopher W. (The Kinghorn Cancer Centre. Cancer Division. Garvan Institute of Medical Research. University of New South Wales) ; Vicentini, Caterina (University and Hospital Trust of Verona. ARC-Net Centre for Applied Research on Cancer) ; Wu, Jianmin (The Kinghorn Cancer Centre. Cancer Division. Garvan Institute of Medical Research. University of New South Wales) ; Zeps, Nikolajs (Epworth HealthCare) ; Behren, Andreas (Olivia Newton-John Cancer Research Institute. La Trobe University) ; Burke, Hazel (Melanoma Institute Australia. The University of Sydney) ; Cebon, Jonathan (Olivia Newton-John Cancer Research Institute. La Trobe University) ; Dagg, Rebecca A. (Children's Hospital at Westmead. The University of Sydney) ; De Paoli-Iseppi, Ricardo (Melanoma Institute Australia. The University of Sydney) ; Dutton-Regester, Ken (Department of Genetics and Computational Biology. QIMR Berghofer Medical Research Institute) ; Field, Matthew A. (Australian Institute of Tropical Health and Medicine. James Cook University) ; Fitzgerald, Anna (Bioplatforms Australia) ; Hersey, Peter (Melanoma Institute Australia. The University of Sydney) ; Jakrot, Valerie (Melanoma Institute Australia. The University of Sydney) ; Johansson, Peter A. (Department of Genetics and Computational Biology. QIMR Berghofer Medical Research Institute) ; Kakavand, Hojabr (Melanoma Institute Australia. The University of Sydney) ; Kefford, Richard F. (Melanoma Institute Australia. Macquarie University) ; Lau, Loretta M. S. (Children's Medical Research Institute) ; Long, Georgina V. (Melanoma Institute Australia. The University of Sydney) ; Pickett, Hilda A. (Children's Medical Research Institute) ; Pritchard, Antonia L. (Department of Genetics and Computational Biology. QIMR Berghofer Medical Research Institute) ; Pupo, Gulietta M. (Centre for Cancer Research. The Westmead Millennium Institute for Medical Research. University of Sydney. Westmead Hospital) ; Saw, Robyn P. M. (Melanoma Institute Australia. The University of Sydney) ; Schramm, Sarah-Jane (Translational Cancer Research Centre. The University of Sydney at the Westmead Institute) ; Shang, Catherine A. (Bioplatforms Australia) ; Shang, Ping (Melanoma Institute Australia. The University of Sydney) ; Spillane, Andrew J. (Melanoma Institute Australia. The University of Sydney) ; Stretch, Jonathan R. (Melanoma Institute Australia. The University of Sydney) ; Tembe, Varsha (Translational Cancer Research Centre. The University of Sydney at the Westmead Institute) ; Thompson, John F. (Melanoma Institute Australia. The University of Sydney) ; Vilain, Ricardo E. (Discipline of Pathology. Sydney Medical School. The University of Sydney) ; Wilmott, James S. (Melanoma Institute Australia. The University of Sydney) ; Yang, Jean Yee (School of Mathematics and Statistics. The University of Sydney) ; Hayward, Nicholas K. (Melanoma Institute Australia. The University of Sydney) ; Mann, Graham J. (Melanoma Institute Australia. The University of Sydney) ; Scolyer, Richard A. (Royal Prince Alfred Hospital) ; Bartlett, John (Ontario Tumour Bank. Ontario Institute for Cancer Research) ; Bavi, Prashant (PanCuRx Translational Research Initiative. Ontario Institute for Cancer Research) ; Chadwick, Dianne E. (BioSpecimen Sciences Program. University Health Network) ; Chan-Seng-Yue, Michelle (PanCuRx Translational Research Initiative. Ontario Institute for Cancer Research) ; Cleary, Sean (Hepatobiliary/Pancreatic Surgical Oncology Program. University Health Network) ; Connor, Ashton A. (Lunenfeld-Tanenbaum Research Institute. Mount Sinai Hospital) ; Czajka, Karolina (Genomics Research Program. Ontario Institute for Cancer Research) ; Denroche, Robert E. (PanCuRx Translational Research Initiative. Ontario Institute for Cancer Research) ; Dhani, Neesha C. (Division of Medical Oncology. Princess Margaret Cancer Centre) ; Eagles, Jenna (Genomics Research Program. Ontario Institute for Cancer Research) ; Gallinger, Steven (Lunenfeld-Tanenbaum Research Institute. Mount Sinai Hospital) ; Grant, Robert C. (Lunenfeld-Tanenbaum Research Institute. Mount Sinai Hospital) ; Hedley, David (Division of Medical Oncology. Princess Margaret Cancer Centre) ; Hollingsworth, Michael A. (University of Nebraska Medical Center) ; Jang, Gun Ho (PanCuRx Translational Research Initiative. Ontario Institute for Cancer Research) ; Johns, Jeremy (Genomics Research Program. Ontario Institute for Cancer Research) ; Kalimuthu, Sangeetha (PanCuRx Translational Research Initiative. Ontario Institute for Cancer Research) ; Liang, Sheng-Ben (BioSpecimen Sciences Program. University Health Network) ; Lungu, Ilinca (Transformative Pathology. Ontario Institute for Cancer Research) ; Luo, Xuemei (Computational Biology Program. Ontario Institute for Cancer Research) ; Mbabaali, Faridah (Genomics Research Program. Ontario Institute for Cancer Research) ; McPherson, Treasa A. (Lunenfeld-Tanenbaum Research Institute. Mount Sinai Hospital) ; Miller, Jessica K. (Genomics Research Program. Ontario Institute for Cancer Research) ; Moore, Malcolm J. (Division of Medical Oncology. Princess Margaret Cancer Centre) ; Notta, Faiyaz (University Health Network. Princess Margaret Cancer Centre) ; Pasternack, Danielle (Genomics Research Program. Ontario Institute for Cancer Research) ; Petersen, Gloria M. (Department of Health Sciences Research. Mayo Clinic) ; Roehrl, Michael H. A. (Department of Pathology. Human Oncology and Pathogenesis Program. Memorial Sloan Kettering Cancer Center) ; Sam, Michelle (Genomics Research Program. Ontario Institute for Cancer Research) ; Selander, Iris (Lunenfeld-Tanenbaum Research Institute. Mount Sinai Hospital) ; Serra, Stefano (Department of Clinical Pathology. University of Melbourne) ; Shahabi, Sagedeh (BioSpecimen Sciences Program. University Health Network) ; Thayer, Sarah P. (University of Nebraska Medical Center) ; Timms, Lee E. (Genomics Research Program. Ontario Institute for Cancer Research) ; Wilson, Gavin W. (PanCuRx Translational Research Initiative. Ontario Institute for Cancer Research) ; Wilson, Julie M. (PanCuRx Translational Research Initiative. Ontario Institute for Cancer Research) ; Wouters, Bradly G. (Department of Medical Biophysics. University of Toronto) ; McPherson, John D. (Department of Biochemistry and Molecular Medicine. University California at Davis) ; Beck, Timothy A. (Human Longevity) ; Bhandari, Vinayak (Computational Biology Program. Ontario Institute for Cancer Research) ; Collins, Colin C. (Vancouver Prostate Centre) ; Fleshner, Neil E. (Department of Surgical Oncology. Princess Margaret Cancer Centre) ; Fox, Natalie S. (Computational Biology Program. Ontario Institute for Cancer Research) ; Fraser, Michael (Computational Biology Program. Ontario Institute for Cancer Research) ; Heisler, Lawrence E. (Genome Informatics Program. Ontario Institute for Cancer Research) ; Lalonde, Emilie (Computational Biology Program. Ontario Institute for Cancer Research) ; Livingstone, Julie (Computational Biology Program. Ontario Institute for Cancer Research) ; Meng, Alice (STTARR Innovation Facility. Princess Margaret Cancer Centre) ; Sabelnykova, Veronica Y. (Computational Biology Program. Ontario Institute for Cancer Research) ; Shiah, Yu-Jia (Computational Biology Program. Ontario Institute for Cancer Research) ; Van der Kwast, Theodorus (Department of Pathology. Toronto General Hospital) ; Bristow, Robert G. (Radiation Medicine Program. Princess Margaret Cancer Centre) ; Ding, Shuai (Hefei University of Technology) ; Fan, Daiming (State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases. Fourth Military Medical University) ; Li, Lin (BGI-Shenzhen) ; Nie, Yongzhan (Fourth Military Medical University) ; Xiao, Xiao (School of Computer Science and Technology. Xi'an Jiaotong University) ; Xing, Rui (Laboratory of Molecular Oncology. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education). Peking University Cancer Hospital & Institute) ; Yang, Shanling (Hefei University of Technology) ; Yu, Yingyan (Department of Surgery. Ruijin Hospital. Shanghai Jiaotong University School of Medicine) ; Zhou, Yong (BGI-Shenzhen) ; Banks, Rosamonde E. (Leeds Institute of Medical Research. University of Leeds. St James's University Hospital) ; Bourque, Guillaume (Department of Human Genetics. McGill University) ; Brennan, Paul (International Agency for Research on Cancer) ; Letourneau, Louis (McGill University and Genome Quebec Innovation Centre) ; Riazalhosseini, Yasser (Department of Human Genetics. McGill University) ; Scelo, Ghislaine (International Agency for Research on Cancer) ; Vasudev, Naveen (St James Institute of Oncology. University of Leeds. St James's University Hospital) ; Viksna, Juris (Institute of Mathematics and Computer Science. University of Latvia) ; Lathrop, Mark (Department of Human Genetics. McGill University) ; Tost, Jörg (Centre National de Génotypage. CEA - Institute de Génomique) ; Ahn, Sung-Min (Department of Oncology. Gil Medical Center. Gachon University) ; Aparicio, Samuel (Department of Molecular Oncology. BC Cancer Agency) ; Arnould, Laurent (Los Alamos National Laboratory) ; Aure, Miriam R. R. (Department of Genetics. Institute for Cancer Research. Oslo University Hospital. The Norwegian Radium Hospital) ; Bhosle, Shriram G. (Wellcome Trust Sanger Institute (Regne Unit)) ; Birney, Ewan (European Molecular Biology Laboratory (EMBL). European Bioinformatics Institute (EMBL-EBI)) ; Borg, Ake (Lund University) ; Boyault, Sandrine (Translational Research Lab. Centre Léon Bérard) ; Brinkman, Arie B. (Department of Molecular Biology. Faculty of Science. Radboud Institute for Molecular Life Sciences. Radboud University) ; Brock, Jane E. (Department of Pathology. Brigham and Women's Hospital. Harvard Medical School) ; Broeks, Annegien (Department of Molecular Pathology. The Netherlands Cancer Institute) ; Børresen-Dale, Anne-Lise (Department of Genetics. Institute for Cancer Research. Oslo University Hospital. The Norwegian Radium Hospital) ; Caldas, Carlos (Department of Oncology. University of Cambridge) ; Chin, Suet-Feung (Department of Oncology. University of Cambridge) ; Davies, Helen (Wellcome Trust Sanger Institute (Regne Unit)) ; Desmedt, Christine (Laboratory for Translational Breast Cancer Research. Department of Oncology. KU Leuven) ; Dirix, Luc (Translational Cancer Research Unit. GZA Hospitals St-Augustinus. Center for Oncological Research. Faculty of Medicine and Health Sciences. University of Antwerp) ; Dronov, S. (Wellcome Trust Sanger Institute (Regne Unit)) ; Ehinger, Anna (Department of Gynecology & Obstetrics and Department of Clinical Sciences. Skåne University Hospital. Lund University) ; Eyfjord, Jorunn E. (Icelandic Cancer Registry. Icelandic Cancer Society) ; Fatima, Aquila (Department of Cancer Biology. Dana-Farber Cancer Institute) ; Foekens, John A. (Department of Medical Oncology. Josephine Nefkens Institute and Cancer Genomics Centre. Erasmus Medical Center) ; Futreal, P. Andrew (National Genotyping Center. Institute of Biomedical Sciences. Academia Sinica) ; Garred, Øystein (Faculty of Medicine and Institute of Clinical Medicine. University of Oslo) ; Giri, Dilip D. (Department of Pathology. Memorial Sloan Kettering Cancer Center) ; Glodzik, Dominik (Wellcome Trust Sanger Institute (Regne Unit)) ; Grabau, Dorthe (Department of Pathology. Skåne University Hospital. Lund University) ; Hilmarsdottir, Holmfridur (Icelandic Cancer Registry. Icelandic Cancer Society) ; Hooijer, Gerrit Karel Jan (Department of Pathology. Academic Medical Center) ; Jacquemier, Jocelyne (Department of Pathology. College of Medicine. Hanyang University) ; Jang, Se Jin (Department of Pathology. Asan Medical Center. College of Medicine. Ulsan University. Songpa-gu) ; Jonasson, Jon G. (Icelandic Cancer Registry. Icelandic Cancer Society) ; Jonkers, Jos (The Netherlands Cancer Institute) ; Kim, Hyung-Yong (Department of Pathology. College of Medicine. Hanyang University) ; King, Tari A. (Department of Surgery. Memorial Sloan Kettering Cancer Center) ; Knappskog, Stian (Wellcome Trust Sanger Institute (Regne Unit)) ; Kong, Gu (Department of Pathology. College of Medicine. Hanyang University) ; Krishnamurthy, Savitri (Morgan Welch Inflammatory Breast Cancer Research Program and Clinic. The University of Texas MD Anderson Cancer Center) ; Lakhani, Sunil R. (The University of Queensland Centre for Clinical Research. The Royal Brisbane & Women's Hospital) ; Langerød, Anita (Department of Genetics. Institute for Cancer Research. Oslo University Hospital. The Norwegian Radium Hospital) ; Larsimont, Denis (Department of Pathology. Institut Jules Bordet) ; Lee, Hee Jin (Department of Pathology. Asan Medical Center. College of Medicine. Ulsan University. Songpa-gu) ; Lee, Jeong-Yeon (Institute for Bioengineering and Biopharmaceutical Research (IBBR). Hanyang University) ; Lee, Ming Ta Michael (National Genotyping Center. Institute of Biomedical Sciences. Academia Sinica) ; Lingjærde, Ole Christian (University of Oslo) ; MacGrogan, Gaetan (Institut Bergonié) ; Martens, John W. M. (Department of Medical Oncology. Josephine Nefkens Institute and Cancer Genomics Centre. Erasmus Medical Center) ; O'Meara, Sarah (Wellcome Trust Sanger Institute (Regne Unit)) ; Pauporté, Iris (Institut National du Cancer (INCA)) ; Pinder, Sarah (Department of Research Oncology. Guy's Hospital. King's Health Partners AHSC. King's College London School of Medicine) ; Pivot, Xavier (University Hospital of Minjoz. INSERM UMR 1098) ; Provenzano, Elena (Cambridge Breast Unit. Addenbrooke's Hospital. Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre) ; Purdie, Colin A. (East of Scotland Breast Service. Ninewells Hospital) ; Ramakrishna, Manasa (Wellcome Trust Sanger Institute (Regne Unit)) ; Ramakrishnan, Kamna (Wellcome Trust Sanger Institute (Regne Unit)) ; Reis-Filho, Jorge (Department of Pathology. Memorial Sloan Kettering Cancer Center) ; Richardson, Andrea L. (Department of Cancer Biology. Dana-Farber Cancer Institute) ; Ringnér, Markus (Lund University) ; Rodriguez, Javier Bartolomé (Barcelona Supercomputing Center) ; Rodríguez-González, Francisco G. (University of Copenhagen) ; Romieu, Gilles (Oncologie Sénologie. ICM Institut Régional du Cancer) ; Salgado, Roberto (Department of Clinical Pathology. University of Melbourne) ; Sauer, Torill (University of Oslo) ; Shepherd, Rebecca (Wellcome Trust Sanger Institute (Regne Unit)) ; Sieuwerts, Anieta M. (Department of Medical Oncology. Josephine Nefkens Institute and Cancer Genomics Centre. Erasmus Medical Center) ; Simpson, Peter T. (The University of Queensland Centre for Clinical Research. The Royal Brisbane & Women's Hospital) ; Smid, Marcel (Department of Medical Oncology. Josephine Nefkens Institute and Cancer Genomics Centre. Erasmus Medical Center) ; Sotiriou, Christos (University of California San Diego) ; Span, Paul N. (Department of Radiation Oncology. Radboud University Nijmegen Medical Centre) ; Stefánsson, Ólafur Andri (University of Iceland) ; Stenhouse, Alasdair (Dundee Cancer Centre. Ninewells Hospital) ; Stunnenberg, Henk G. (Institut Curie. INSERM Unit 830) ; Sweep, Fred (Department of Laboratory Medicine. Radboud University Nijmegen Medical Centre) ; Tan, Benita Kiat Tee (Department of General Surgery. Singapore General Hospital) ; Thomas, Gilles (INCa-Synergie. Centre Léon Bérard. Universite Lyon) ; Thompson, Alastair M. (Dundee Cancer Centre. Ninewells Hospital) ; Tommasi, Stefania (Giovanni Paolo II/I.R.C.C.S. Cancer Institute) ; Treilleux, Isabelle (Université Claude Bernard Lyon 1) ; Tutt, Andrew (Department of Cancer Biology. Dana-Farber Cancer Institute) ; Ueno, Naoto T. (The University of Texas MD Anderson Cancer Center) ; Van Laere, Steven (Translational Cancer Research Unit. GZA Hospitals St-Augustinus. Center for Oncological Research. Faculty of Medicine and Health Sciences. University of Antwerp) ; Van den Eynden, Gert G. (Translational Cancer Research Unit. GZA Hospitals St-Augustinus. Center for Oncological Research. Faculty of Medicine and Health Sciences. University of Antwerp) ; Vermeulen, Peter (Translational Cancer Research Unit. GZA Hospitals St-Augustinus. Center for Oncological Research. Faculty of Medicine and Health Sciences. University of Antwerp) ; Viari, Alain (University and Hospital Trust of Verona. ARC-Net Centre for Applied Research on Cancer) ; Vincent-Salomon, Anne (Institut Curie. INSERM Unit 830) ; Wong, Bernice H. (NCCS-VARI Translational Research Laboratory. National Cancer Centre Singapore) ; Yates, Lucy (Wellcome Trust Sanger Institute (Regne Unit)) ; Zou, Xueqing (Wellcome Trust Sanger Institute (Regne Unit)) ; van Deurzen, Caroline H. M. (Department of Pathology. Erasmus Medical Center Rotterdam) ; van de Vijver, Marc J. (Department of Clinical Pathology. University of Melbourne) ; van't Veer, L. (Division of Molecular Carcinogenesis. The Netherlands Cancer Institute) ; Ammerpohl, Ole (University Hospital of Ulm) ; Aukema, Sietse (Hematopathology Section. Institute of Pathology. Christian-Albrechts-University) ; Bergmann, Anke K. (Department of Human Genetics. Hannover Medical School) ; Bernhart, Stephan H. (Transcriptome Bioinformatics. LIFE Research Center for Civilization Diseases. University of Leipzig) ; Borkhardt, Arndt (Department of Pediatric Oncology. Hematology and Clinical Immunology. Heinrich-Heine-University) ; Borst, Christoph (Department of Internal Medicine/Hematology. Friedrich-Ebert-Hospital) ; Burkhardt, Birgit (Pediatric Hematology and Oncology. University Hospital Muenster) ; Claviez, Alexander (Department of Pediatrics. University Hospital Schleswig-Holstein) ; Goebler, Maria Elisabeth (Department of Medicine II. University of Würzburg) ; Haake, Andrea (Institute of Human Genetics. Christian-Albrechts-University) ; Haas, Siegfried (Department of Internal Medicine/Hematology. Friedrich-Ebert-Hospital) ; Hansmann, Martin (Senckenberg Institute of Pathology. University of Frankfurt Medical School) ; Hoell, Jessica I. (Department of Pediatric Oncology. Hematology and Clinical Immunology. Heinrich-Heine-University) ; Hummel, Michael (Institute of Pathology. Charité-University Medicine Berlin) ; Karsch, Dennis (Department for Internal Medicine II. University Hospital Schleswig-Holstein) ; Klapper, Wolfram (Hematopathology Section. Institute of Pathology. Christian-Albrechts-University) ; Kneba, Michael (Department for Internal Medicine II. University Hospital Schleswig-Holstein) ; Kreuz, Markus (Institute for Medical Informatics Statistics and Epidemiology. University of Leipzig) ; Kube, Dieter (Department of Hematology and Oncology. Georg-Augusts-University of Göttingen) ; Küppers, Ralf (Institute of Cell Biology (Cancer Research). University of Duisburg-Essen) ; Lenze, Dido (Institute of Pathology. Charité-University Medicine Berlin) ; Loeffler, Markus (Institute for Medical Informatics Statistics and Epidemiology. University of Leipzig) ; López, Cristina (Institute of Human Genetics. Christian-Albrechts-University) ; Mantovani-Löffler, Luisa (MVZ Department of Oncology. PraxisClinic am Johannisplatz) ; Möller, Peter (Institute of Pathology. Ulm University and University Hospital of Ulm) ; Ott, German (Department of Pathology. Robert-Bosch-Hospital) ; Radlwimmer, Bernhard (Division of Molecular Genetics. German Cancer Research Center (DKFZ)) ; Richter, Julia (Hematopathology Section. Institute of Pathology. Christian-Albrechts-University) ; Rohde, Marius (Pediatric Hematology and Oncology. University Hospital Giessen) ; Rosenstiel, Philip C. (Institute of Clinical Molecular Biology. Christian-Albrechts-University) ; Rosenwald, Andreas (Institute of Pathology. University of Wuerzburg) ; Schilhabel, Markus B. (Institute of Clinical Molecular Biology. Christian-Albrechts-University) ; Schreiber, Stefan (Department of General Internal Medicine. University Kiel) ; Stadler, Peter F. (Transcriptome Bioinformatics. LIFE Research Center for Civilization Diseases. University of Leipzig) ; Staib, Peter (Clinic for Hematology and Oncology. St-Antonius-Hospital) ; Stilgenbauer, Stephan (Department for Internal Medicine III. University of Ulm and University Hospital of Ulm) ; Sungalee, Stephanie (European Molecular Biology Laboratory (EMBL). Genome Biology Unit) ; Szczepanowski, Monika (Hematopathology Section. Institute of Pathology. Christian-Albrechts-University) ; Toprak, Umut H. (Neuroblastoma Genomics. German Cancer Research Center (DKFZ)) ; Trümper, Lorenz H. P. (Department of Hematology and Oncology. Georg-Augusts-University of Göttingen) ; Wagener, Rabea (Institute of Human Genetics. Christian-Albrechts-University) ; Zenz, Thorsten (National Center for Tumor Diseases (NCT) Heidelberg) ; Hovestadt, Volker (Division of Molecular Genetics. German Cancer Research Center (DKFZ)) ; von Kalle, Christof (German Cancer Research Center (DKFZ)) ; Kool, Marcel (Hopp Children's Cancer Center (KiTZ)) ; Korshunov, Andrey (Functional and Structural Genomics. German Cancer Research Center (DKFZ)) ; Landgraf, Pablo (University of Düsseldorf) ; Lehrach, Hans (Department of Vertebrate Genomics/Otto Warburg Laboratory Gene Regulation and Systems Biology of Cancer. Max Planck Institute for Molecular Genetics) ; Northcott, Paul A. (St Jude Children's Research Hospital) ; Pfister, Stefan M. (Heidelberg University Hospital) ; Reifenberger, Guido (University of Düsseldorf) ; Warnatz, Hans-Jörg (Department of Vertebrate Genomics/Otto Warburg Laboratory Gene Regulation and Systems Biology of Cancer. Max Planck Institute for Molecular Genetics) ; Wolf, Stephan (Genomics and Proteomics Core Facility High Throughput Sequencing Unit. German Cancer Research Center (DKFZ)) ; Yaspo, Marie-Laure (Department of Vertebrate Genomics/Otto Warburg Laboratory Gene Regulation and Systems Biology of Cancer. Max Planck Institute for Molecular Genetics) ; Assenov, Yassen (Epigenomics and Cancer Risk Factors. German Cancer Research Center (DKFZ)) ; Gerhauser, Clarissa (Cancer Epigenomics. German Cancer Research Center (DKFZ)) ; Minner, Sarah (University Medical Center Hamburg-Eppendorf) ; Schlomm, Thorsten (Martini-Clinic. Prostate Cancer Center. University Medical Center Hamburg-Eppendorf) ; Simon, Ronald (Institute of Pathology. University Medical Center Hamburg-Eppendorf) ; Sauter, Guido (Institute of Pathology. University Medical Center Hamburg-Eppendorf) ; Sültmann, Holger (Division of Cancer Genome Research. German Cancer Research Center (DKFZ)) ; Biswas, Nidhan K. (National Institute of Biomedical Genomics) ; Maitra, Arindam (National Institute of Biomedical Genomics) ; Majumder, Partha P. (National Institute of Biomedical Genomics) ; Sarin, Rajiv (Advanced Centre for Treatment Research & Education in Cancer. Tata Memorial Centre) ; Barbi, Stefano (Department of Pathology and Diagnostics. University and Hospital Trust of Verona) ; Bonizzato, Giada (University and Hospital Trust of Verona. ARC-Net Centre for Applied Research on Cancer) ; Cantù, Cinzia (University and Hospital Trust of Verona. ARC-Net Centre for Applied Research on Cancer) ; Dei Tos, Angelo P. (Department of Pathology. General Hospital of Treviso. Department of Medicine. University of Padua) ; Fassan, Matteo (Department of Medicine (DIMED). Surgical Pathology Unit. University of Padua) ; Grimaldi, Sonia (University and Hospital Trust of Verona. ARC-Net Centre for Applied Research on Cancer) ; Luchini, Claudio (Department of Diagnostics and Public Health. University and Hospital Trust of Verona) ; Malleo, Giuseppe (University Hospital of Verona (Itàlia)) ; Marchegiani, Giovanni (University Hospital of Verona (Itàlia)) ; Milella, Michele (Medical Oncology. University and Hospital Trust of Verona) ; Paiella, Salvatore (University Hospital of Verona (Itàlia)) ; Pea, Antonio (University Hospital of Verona (Itàlia)) ; Pederzoli, Paolo (University Hospital of Verona (Itàlia)) ; Ruzzenente, Andrea (University Hospital of Verona (Itàlia)) ; Salvia, Roberto (University Hospital of Verona (Itàlia)) ; Sperandio, Nicola (University and Hospital Trust of Verona. ARC-Net Centre for Applied Research on Cancer) ; Arai, Yasuhito (Division of Cancer Genomics. National Cancer Center Research Institute. National Cancer Center) ; Hama, Natsuko (Division of Cancer Genomics. National Cancer Center Research Institute. National Cancer Center) ; Hiraoka, Nobuyoshi (Department of Hepatobiliary and Pancreatic Oncology. Hepatobiliary and Pancreatic Surgery Division. Division of Pathology and Clinical Laboratories. National Cancer Center Hospital. Chuo-ku) ; Hosoda, Fumie (Division of Cancer Genomics. National Cancer Center Research Institute. National Cancer Center) ; Nakamura, Hiromi (Division of Cancer Genomics. National Cancer Center Research Institute. National Cancer Center) ; Ojima, Hidenori (Department of Pathology. Keio University School of Medicine) ; Okusaka, Takuji (Department of Hepatobiliary and Pancreatic Oncology. National Cancer Center Hospital) ; Totoki, Yasushi (Division of Cancer Genomics. National Cancer Center Research Institute. National Cancer Center) ; Urushidate, Tomoko (Laboratory of Molecular Medicine. Human Genome Center. The Institute of Medical Science. The University of Tokyo) ; Fukayama, Masashi (Department of Pathology. Graduate School of Medicine. The University of Tokyo. Bunkyo-ku) ; Ishikawa, Shumpei (Preventive Medicine. Graduate School of Medicine. The University of Tokyo) ; Katai, Hitoshi (Gastric Surgery Division. Division of Pathology and Clinical Laboratories. National Cancer Center Hospital) ; Katoh, Hiroto (Preventive Medicine. Graduate School of Medicine. The University of Tokyo) ; Komura, Daisuke (Preventive Medicine. Graduate School of Medicine. The University of Tokyo) ; Rokutan, Hirofumi (Department of Bioinformatics. Division of Cancer Genomics. National Cancer Center Research Institute. National Cancer Center) ; Saito-Adachi, Mihoko (Department of Bioinformatics. Division of Cancer Genomics. National Cancer Center Research Institute. National Cancer Center) ; Suzuki, Akihiro (Department of Gastroenterology and Hepatology. Yokohama City University Graduate School of Medicine) ; Taniguchi, Hirokazu (Laboratory of Molecular Medicine. Human Genome Center. The Institute of Medical Science. University of Tokyo) ; Tatsuno, Kenji (Genome Science Division. Research Center for Advanced Science and Technology. The University of Tokyo) ; Ushiku, Tetsuo (Department of Pathology. Graduate School of Medicine. The University of Tokyo. Bunkyo-ku) ; Yachida, Shinichi (Department of Cancer Genome Informatics. Graduate School of Medicine. Osaka University) ; Yamamoto, Shogo (Genome Science Division. Research Center for Advanced Science and Technology. The University of Tokyo) ; Aikata, Hiroshi (Hiroshima University) ; Arihiro, Koji (Hiroshima University) ; Ariizumi, Shun-ichi (Tokyo Women's Medical University) ; Chayama, Kazuaki (Hiroshima University) ; Furuta, Mayuko (RIKEN Center for Integrative Medical Sciences) ; Gotoh, Kunihito (Osaka International Cancer Center) ; Hayami, Shinya (Wakayama Medical University) ; Hirano, Satoshi (Hokkaido University) ; Kawakami, Yoshiiku (Hiroshima University) ; Maejima, Kazuhiro (RIKEN Center for Integrative Medical Sciences) ; Nakamura, Toru (Hokkaido University) ; Nakano, Kaoru (RIKEN Center for Integrative Medical Sciences) ; Ohdan, Hideki (Hiroshima University) ; Sasaki-Oku, Aya (RIKEN Center for Integrative Medical Sciences) ; Tanaka, Hiroko (The Institute of Medical Science. The University of Tokyo) ; Ueno, Masashi (Wakayama Medical University) ; Yamamoto, Masakazu (Tokyo Women's Medical University) ; Yamaue, Hiroki (Wakayama Medical University) ; Choo, Su Pin (Division of Medical Oncology. National Cancer Centre) ; Cutcutache, Ioana (Centre for Computational Biology. Duke-NUS Medical School) ; Khuntikeo, Narong (Cholangiocarcinoma Screening and Care Program and Liver Fluke and Cholangiocarcinoma Research Centre. Faculty of Medicine. Khon Kaen University) ; Ong, Choon Kiat (Lymphoma Genomic Translational Research Laboratory. National Cancer Centre) ; Pairojkul, Chawalit (Department of Clinical Pathology. University of Melbourne) ; Popescu, Irinel (Center of Digestive Diseases and Liver Transplantation. Fundeni Clinical Institute) ; Ahn, Keun Soo (Division of Hepatobiliary and Pancreatic Surgery. Department of Surgery. School of Medicine. Keimyung University Dongsan Medical Center) ; Aymerich, Marta (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Lopez-Guillermo, Armando (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; López-Otín, Carlos (Department of Biochemistry and Molecular Biology. Faculty of Medicine. University Institute of Oncology-IUOPA) ; Puente, Xose S (University of Oviedo) ; Campo, Elias (Spanish Ministry of Science and Innovation) ; Amary, Fernanda (Royal National Orthopaedic Hospital (Bolsover)) ; Baumhoer, Daniel (Oslo University Hospital (Oslo, Noruega)) ; Behjati, Sam (Wellcome Trust Sanger Institute (Regne Unit)) ; Bjerkehagen, Bodil (Institute of Clinical Medicine and Institute of Oral Biology. University of Oslo) ; Futreal, P. Andrew (National Genotyping Center. Institute of Biomedical Sciences. Academia Sinica) ; Myklebost, Ola (Department of Clinical Science. University of Bergen) ; Pillay, Nischalan (Research Department of Pathology. University College London Cancer Institute) ; Tarpey, Patrick (East Anglian Medical Genetics Service. Cambridge University Hospitals NHS Foundation Trust) ; Tirabosco, Roberto (Royal National Orthopaedic Hospital (Stanmore)) ; Zaikova, Olga (Oslo University Hospital (Oslo, Noruega)) ; Flanagan, Adrienne M. (Department of Pathology (Research). University College London Cancer Institute) ; Boultwood, Jacqueline (University of Oxford. Radcliffe Department of Medicine) ; Bowen, David T. (Wellcome Trust Sanger Institute (Regne Unit)) ; Cazzola, Mario (University of Pavia) ; Green, Anthony R. (University of Cambridge) ; Hellstrom-Lindberg, Eva (Karolinska Institutet (Estocolm, Suècia)) ; Malcovati, Luca (University of Pavia) ; Nangalia, Jyoti (Wellcome Trust Sanger Institute (Regne Unit)) ; Papaemmanuil, Elli (Wellcome Trust Sanger Institute (Regne Unit)) ; Vyas, Paresh (University of Oxford) ; Ang, Yeng (Salford Royal NHS Foundation Trust) ; Barr, Hugh (Gloucester Royal Hospital) ; Beardsmore, Duncan (Royal Stoke University Hospital) ; Eldridge, Matthew (Cancer Research UK Cambridge Institute. University of Cambridge) ; Gossage, James (St Thomas's Hospital) ; Grehan, Nicola (MRC Cancer Unit. University of Cambridge) ; Hanna, George B. (Imperial College NHS Trust. Imperial College London) ; Hayes, Stephen J. (Faculty of Biology. Medicine and Health. The University of Manchester) ; Hupp, Ted R. (Edinburgh Royal Infirmary) ; Khoo, David (Barking Havering and Redbridge University Hospitals NHS Trust) ; Lagergren, Jesper (King's College London) ; Lovat, Laurence B (University College London) ; MacRae, Shona (Cancer Unit. MRC University of Cambridge) ; O'Donovan, Maria (MRC Cancer Unit. University of Cambridge) ; O'Neill, J. Robert (Cambridge University Hospitals NHS Foundation Trust (Regne Unit)) ; Parsons, Simon L. (Nottingham University Hospitals NHS Trust (Regne Unit)) ; Preston, Shaun R. (St Luke's Cancer Centre. Royal Surrey County Hospital NHS Foundation Trust) ; Puig, Sonia (University of North Carolina at Chapel Hill) ; Roques, Tom (Norfolk and Norwich University Hospital NHS Trust) ; Sanders, Grant (Lineberger Comprehensive Cancer Center. University of North Carolina at Chapel Hill) ; Sothi, Sharmila (University Hospitals Coventry and Warwickshire NHS Trust) ; Tavaré, Simon (Cancer Research UK Cambridge Institute. University of Cambridge) ; Tucker, Olga (Birmingham Women's and Children's Hospital (Regne Unit)) ; Turkington, Richard (Centre for Cancer Research and Cell Biology. Queen's University) ; Underwood, Timothy J. (School of Cancer Sciences. Faculty of Medicine. University of Southampton) ; Welch, Ian (Wythenshawe Hospital) ; Fitzgerald, Rebecca C. (MRC Cancer Unit. University of Cambridge) ; Berney, Daniel M. (University of London) ; de Bono, Johann S. (The Institute of Cancer Research) ; Cahill, Declan (Royal Marsden NHS Foundation Trust. London and Sutton) ; Camacho, Niedzica (The Institute of Cancer Research) ; Dennis, Nening M. (Royal Marsden NHS Foundation Trust. London and Sutton) ; Dudderidge, Tim (University Hospital Southampton NHS Foundation Trust (Regne Unit)) ; Edwards, Sandra E. (The Institute of Cancer Research) ; Fisher, Cyril (Royal Marsden NHS Foundation Trust. London and Sutton) ; Foster, Christopher S. (University of Liverpool) ; Ghori, Mohammed (Wellcome Trust Sanger Institute (Regne Unit)) ; Gill, Pelvender (University of Oxford) ; Gnanapragasam, Vincent J. (Academic Urology Group. Department of Surgery. University of Cambridge) ; Gundem, Gunes (Memorial Sloan Kettering Cancer Center) ; Hamdy, Freddie C (University of Oxford. Oxford) ; Hawkins, Steve (Cancer Research UK Cambridge Institute. University of Cambridge) ; Hazell, Steve (Royal Marsden NHS Foundation Trust. London and Sutton) ; Howat, William (Cambridge University Hospitals NHS Foundation Trust (Regne Unit)) ; Isaacs, William B. (Department of Urology. James Buchanan Brady Urological Institute. Johns Hopkins University School of Medicine) ; Karaszi, Katalin (University of Oxford) ; Kay, Jonathan D. (University College London) ; Khoo, Vincent (Royal Marsden NHS Foundation Trust. London and Sutton) ; Kote-Jarai, Zsofia (The Institute of Cancer Research) ; Kremeyer, Barbara (Wellcome Trust Sanger Institute (Regne Unit)) ; Kumar, Pardeep (Royal Marsden NHS Foundation Trust. London and Sutton) ; Lambert, Adam (University of Oxford) ; Leongamornlert, Daniel A. (Wellcome Trust Sanger Institute (Regne Unit)) ; Livni, Naomi (Royal Marsden NHS Foundation Trust. London and Sutton) ; Lu, Yong-Jie (Second Military Medical University) ; Luxton, Hayley J. (University College London) ; Marsden, Luke (University of Oxford) ; Massie, Charlie E. (Cancer Research UK Cambridge Institute. University of Cambridge) ; Matthews, Lucy (The Institute of Cancer Research) ; Mayer, Erik (Imperial College London) ; McDermott, Ultan (Wellcome Trust Sanger Institute (Regne Unit)) ; Merson, Susan (The Institute of Cancer Research) ; Neal, David E. (Cambridge University Hospitals NHS Foundation Trust (Regne Unit)) ; Ng, Anthony (The Chinese University of Hong Kong) ; Nicol, David (Royal Marsden NHS Foundation Trust. London and Sutton) ; Ogden, Christopher (Royal Marsden NHS Foundation Trust. London and Sutton) ; Rowe, Edward W. (Royal Marsden NHS Foundation Trust. London and Sutton) ; Shah, Nimish C. (Cambridge University Hospitals NHS Foundation Trust (Regne Unit)) ; Thomas, Sarah (Royal Marsden NHS Foundation Trust. London and Sutton) ; Thompson, Alan (Royal Marsden NHS Foundation Trust. London and Sutton) ; Verrill, Clare (John Radcliffe Hospital (Oxford, Regne Unit)) ; Visakorpi, Tapio (Faculty of Medicine and Health Technology. Tampere University and Tays Cancer Center. Tampere University Hospital) ; Warren, Anne Y. (Cambridge University Hospitals NHS Foundation Trust (Regne Unit)) ; Whitaker, Hayley C. (University College London) ; Zhang, Hongwei (Second Military Medical University, Shanghai) ; van As, Nicholas (Royal Marsden NHS Foundation Trust. London and Sutton) ; Eeles, Rosalind A. (Royal Marsden NHS Foundation Trust. London and Sutton) ; Abeshouse, Adam (Memorial Sloan Kettering Cancer Center) ; Agrawal, Nishant (University of Chicago) ; Akbani, Rehan (Department of Bioinformatics and Computational Biology and Department of Systems Biology. The University of Texas MD Anderson Cancer Center) ; Al-Ahmadie, Hikmat (Memorial Sloan Kettering Cancer Center) ; Albert, Matthew L. (Ontario Tumour Bank. Ontario Institute for Cancer Research) ; Aldape, Kenneth (The University of Texas MD Anderson Cancer Center) ; Ally, Adrian (Canada's Michael Smith Genome Sciences Center. BC Cancer Agency) ; Appelbaum, Elisabeth L. (University College London) ; Armenia, Joshua (Memorial Sloan Kettering Cancer Center) ; Asa, Sylvia (University Health Network) ; Auman, J. Todd (Department of Pathology and Laboratory Medicine. School of Medicine. University of North Carolina at Chapel Hill) ; Balasundaram, Miruna (Canada's Michael Smith Genome Sciences Center. BC Cancer Agency) ; Balu, Saianand (Lineberger Comprehensive Cancer Center. University of North Carolina at Chapel Hill) ; Barnholtz-Sloan, Jill (Research Health Analytics and Informatics. University Hospitals Cleveland Medical Center) ; Bathe, Oliver F. (Department of Surgery and Department of Oncology. University of Calgary) ; Baylin, Stephen B. (University Hospital Southampton NHS Foundation Trust (Regne Unit)) ; Benz, Christopher (Buck Institute for Research on Aging) ; Berchuck, Andrew (Duke University Medical Center) ; Berrios, Mario (USC Norris Comprehensive Cancer Center. University of Southern California) ; Bigner, Darell (The Preston Robert Tisch Brain Tumor Center. Duke University Medical Center) ; Birrer, Michael (Massachusetts General Hospital (Boston)) ; Bodenheimer, Tom (Lineberger Comprehensive Cancer Center. University of North Carolina at Chapel Hill) ; Boice, Lori (University of North Carolina at Chapel Hill) ; Bootwalla, Moiz S. (USC Norris Comprehensive Cancer Center. University of Southern California) ; Bosenberg, Marcus (Department of Dermatology and Department of Pathology. Yale University) ; Bowlby, Reanne (Canada's Michael Smith Genome Sciences Center. BC Cancer Agency) ; Boyd, Jeffrey (Fox Chase Cancer Center) ; Broaddus, Russell R. (Department of Pathology. The University of Texas MD Anderson Cancer Center) ; Brock, Malcolm (Department of Surgery. Division of Thoracic Surgery. The Johns Hopkins University School of Medicine) ; Brooks, Denise (Canada's Michael Smith Genome Sciences Center. BC Cancer Agency) ; Bullman, Susan (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica). Department of Medical Oncology) ; Caesar-Johnson, Samantha J. (National Cancer Institute. National Institutes of Health) ; Carey, Thomas E. (University of Michigan Comprehensive Cancer Center) ; Carlsen, Rebecca (Canada's Michael Smith Genome Sciences Center. BC Cancer Agency) ; Cerfolio, Robert (University of Alabama at Birmingham) ; Chandan, Vishal S. (Division of Anatomic Pathology. Mayo Clinic) ; Chen, Hsiao-Wei (Memorial Sloan Kettering Cancer Center) ; Cherniack, Andrew D. (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica). Department of Medical Oncology) ; Chien, Jeremy (Division of Experimental Pathology. Mayo Clinic) ; Cho, Juok (Broad Institute of MIT and Harvard) ; Chuah, Eric (Canada's Michael Smith Genome Sciences Center. BC Cancer Agency) ; Cibulskis, Carrie (Broad Institute of MIT and Harvard) ; Cope, Leslie (Department of Oncology. The Johns Hopkins School of Medicine. The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University) ; Cordes, Matthew G. (Norfolk and Norwich University Hospital NHS Trust) ; Curley, Erin (International Genomics Consortium) ; Czerniak, Bogdan (Barking Havering and Redbridge University Hospitals NHS Trust) ; Danilova, Ludmila (Department of Oncology. The Johns Hopkins School of Medicine. The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University) ; Davis, Ian J. (Department of Pediatrics and Department of Genetics. University of North Carolina at Chapel Hill) ; Defreitas, Timothy (Broad Institute of MIT and Harvard) ; Demchok, John A. (National Cancer Institute. National Institutes of Health) ; Dhalla, Noreen (Canada's Michael Smith Genome Sciences Center. BC Cancer Agency) ; Dhir, Rajiv (Department of Pathology. UPMC Shadyside) ; Doddapaneni, Harshavardhan (Human Genome Sequencing Center. Baylor College of Medicine) ; El-Naggar, Adel (Barking Havering and Redbridge University Hospitals NHS Trust) ; Felau, Ina (National Cancer Institute. National Institutes of Health) ; Ferguson, Martin L. (National Institutes of Health (Bethesda, Estats Units d'Amèrica). Center for Cancer Genomics) ; Finocchiaro, Gaetano (Department of Neuro-Oncology. Istituto Neurologico Besta) ; Fong, Kwun M. (University of Queensland Thoracic Research Centre. The Prince Charles Hospital) ; Frazer, Scott (Broad Institute of MIT and Harvard) ; Friedman, William (Department of Neurosurgery. University of Florida) ; Fronick, Catrina C. (Norfolk and Norwich University Hospital NHS Trust) ; Fulton, Lucinda A. (The McDonnell Genome Institute. Washington University) ; Gabriel, Stacey B. (Broad Institute of MIT and Harvard) ; Gao, Jianjiong (Memorial Sloan Kettering Cancer Center) ; Gehlenborg, Nils (Center for Biomedical Informatics. Harvard Medical School) ; Gershenwald, Jeffrey E. (Department of Surgical Oncology. The University of Texas MD Anderson Cancer Center) ; Ghossein, Ronald (Department of Pathology. Memorial Sloan Kettering Cancer Center) ; Giama, Nasra H. (Division of Gastroenterology and Hepatology. Mayo Clinic) ; Gibbs, Richard A. (Human Genome Sequencing Center. Baylor College of Medicine) ; Gomez, Carmen (Sylvester Comprehensive Cancer Center. University of Miami) ; Govindan, Ramaswamy (Alvin J. Siteman Cancer Center. Washington University School of Medicine) ; Hayes, D. Neil (University of Tennessee Health Science Center for Cancer Research) ; Hegde, Apurva M. (Department of Bioinformatics and Computational Biology and Department of Systems Biology. The University of Texas MD Anderson Cancer Center) ; Heiman, David I. (Broad Institute of MIT and Harvard) ; Heins, Zachary (Memorial Sloan Kettering Cancer Center) ; Hepperla, Austin J. (Lineberger Comprehensive Cancer Center. University of North Carolina at Chapel Hill) ; Holbrook, Andrea (USC Norris Comprehensive Cancer Center. University of Southern California) ; Holt, Robert A. (Canada's Michael Smith Genome Sciences Center. BC Cancer Agency) ; Hoyle, Alan P. (Lineberger Comprehensive Cancer Center. University of North Carolina at Chapel Hill) ; Hruban, Ralph H. (Department of Oncology. The Johns Hopkins School of Medicine. The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University) ; Hu, Jianhong (Human Genome Sequencing Center. Baylor College of Medicine) ; Huang, Mei (University of North Carolina at Chapel Hill) ; Huntsman, David G (Centre for Translational and Applied Genomics. British Columbia Cancer Agency) ; Huse, Jason (Memorial Sloan Kettering Cancer Center) ; Iacobuzio-Donahue, Christine A. (Department of Pathology. Memorial Sloan Kettering Cancer Center) ; Ittmann, Michael (Michael E. DeBakey Veterans Affairs Medical Center) ; Jayaseelan, Joy C. (Human Genome Sequencing Center. Baylor College of Medicine) ; Jefferys, Stuart R. (Lineberger Comprehensive Cancer Center. University of North Carolina at Chapel Hill) ; Jones, Corbin D. (Carolina Center for Genome Sciences. University of North Carolina at Chapel Hill) ; Jones, Steven J. M. (Canada's Michael Smith Genome Sciences Centre. BC Cancer Agency) ; Juhl, Hartmut (Indivumed) ; Kang, Koo Jeong (Division of Hepatobiliary and Pancreatic Surgery. Department of Surgery. School of Medicine. Keimyung University Dong-san Medical Center) ; Karlan, Beth (Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute. Cedars-Sinai Medical Center) ; Kasaian, Katayoon (Canada's Michael Smith Genome Sciences Centre. BC Cancer Agency) ; Kebebew, Electron (Endocrine Oncology Branch. Center for Cancer Research. National Cancer Institute. National Institutes of Health) ; Kim, Hark Kyun (National Cancer Center) ; Korchina, Viktoriya (Human Genome Sequencing Center. Baylor College of Medicine) ; Kundra, Ritika (Memorial Sloan Kettering Cancer Center) ; Lai, Phillip H. (USC Norris Comprehensive Cancer Center. University of Southern California) ; Lander, Eric (Broad Institute of MIT and Harvard) ; Le, Xuan (ILSbio. LLC Biobank) ; Lee, Donghoon (Canada's Michael Smith Genome Sciences Center. BC Cancer Agency) ; Levine, Douglas A. (Gynecologic Oncology. NYU Laura and Isaac Perlmutter Cancer Center. New York University) ; Lewis, Lora (Human Genome Sequencing Center. Baylor College of Medicine) ; Ley, Tim (Division of Oncology. Stem Cell Biology Section. Washington University School of Medicine) ; Li, Haiyan Irene (Canada's Michael Smith Genome Sciences Center. BC Cancer Agency) ; Lin, Pei (Broad Institute of MIT and Harvard) ; Linehan, William Marston (Urologic Oncology Branch. Center for Cancer Research. National Cancer Institute. National Institutes of Health) ; Liu, Fei-Fei (University of Toronto) ; Lu, Yiling (Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education). Peking University Cancer Hospital & Institute) ; Lype, Lisa (Institute for Systems Biology) ; Ma, Yussanne (Canada's Michael Smith Genome Sciences Center. BC Cancer Agency) ; Maglinte, Dennis T. (Center for Personalized Medicine. Department of Pathology and Laboratory Medicine. Children's Hospital Los Angeles) ; Mardis, Elaine R. (Institute for Genomic Medicine. Nationwide Children's Hospital) ; Marks, Jeffrey (Department of Surgery. Duke University) ; Marra, Marco A. (Canada's Michael Smith Genome Sciences Center. BC Cancer Agency) ; Matthew, Thomas J. (University of California Santa Cruz) ; Mayo, Michael (Canada's Michael Smith Genome Sciences Center. BC Cancer Agency) ; McCune, Karen (Department of Obstetrics. Gynecology and Reproductive Services. University of California San Francisco) ; Meier, Samuel R. (Broad Institute of MIT and Harvard) ; Meng, Shaowu (Lineberger Comprehensive Cancer Center. University of North Carolina at Chapel Hill) ; Mieczkowski, Piotr A. (Department of Genetics. University of North Carolina at Chapel Hill) ; Mikkelsen, Tom (Department of Neurology and Department of Neurosurgery. Henry Ford Hospital) ; Miller, Christopher A. (The McDonnell Genome Institute. Washington University) ; Mills, Gordon B. (Knight Cancer Institute. Oregon Health & Science University) ; Moore, Richard A. (Canada's Michael Smith Genome Sciences Center. BC Cancer Agency) ; Morrison, Carl (Department of Pathology. Roswell Park Cancer Institute) ; Mose, Lisle E. (Lineberger Comprehensive Cancer Center. University of North Carolina at Chapel Hill) ; Moser, C. D. (Division of Gastroenterology and Hepatology. Mayo Clinic) ; Mungall, Andrew J. (Canada's Michael Smith Genome Sciences Center. BC Cancer Agency) ; Mungall, Karen (Canada's Michael Smith Genome Sciences Center. BC Cancer Agency) ; Mutch, David (Department of Obstetrics and Gynecology. Division of Gynecologic Oncology. Washington University School of Medicine) ; Muzny, Donna M. (Department of Palliative. Rehabilitation and Integrative Medicine. The University of Texas MD Anderson Cancer Center) ; Myers, Jerome (Penrose St Francis Health Services) ; Newton, Yulia (University of California Santa Cruz) ; Noble, Michael S. (Broad Institute of MIT and Harvard) ; O'Donnell, Peter (The University of Chicago) ; O'Neill, Brian Patrick (Department of Neurology. Mayo Clinic) ; Ochoa, Angelica (Memorial Sloan Kettering Cancer Center) ; Park, Ji Wan (Center for Liver Cancer. Research Institute and Hospital. National Cancer Center) ; Parker, Joel S. (Department of Genetics and Lineberger Comprehensive Cancer Center. University of North Carolina at Chapel Hill) ; Pass, Harvey (NYU Langone Medical Center) ; Pastore, Alessandro (Memorial Sloan Kettering Cancer Center) ; Pennell, Nathan A. (Department of Hematology and Medical Oncology. Cleveland Clinic) ; Perou, Charles M. (Department of Genetics. Department of Pathology and Laboratory Medicine. School of Medicine. University of North Carolina at Chapel Hill) ; Petrelli, Nicholas (Helen F. Graham Cancer Center at Christiana Care Health Systems) ; Potapova, Olga (Cureline) ; Rader, Janet S. (Department of Obstetrics and Gynecology. Medical College of Wisconsin) ; Ramalingam, Suresh (Hematology and Medical Oncology. Winship Cancer Institute of Emory University) ; Rathmell, W. Kimryn (Vanderbilt Ingram Cancer Center. Vanderbilt University) ; Reuter, Victor (Department of Pathology. Memorial Sloan Kettering Cancer Center) ; Reynolds, Sheila M. (Institute for Systems Biology) ; Ringel, Matthew (Ohio State University College of Medicine and Arthur G. James Comprehensive Cancer Center) ; Roach, Jeffrey (Research Computing Center. University of North Carolina at Chapel Hill) ; Roberts, Lewis R. (Division of Gastroenterology and Hepatology. Mayo Clinic) ; Robertson, A. Gordon (Canada's Michael Smith Genome Sciences Center. BC Cancer Agency) ; Sadeghi, Sara (Canada's Michael Smith Genome Sciences Center. BC Cancer Agency) ; Saller, Charles (Analytical Biological Services) ; Sanchez-Vega, Francisco (Memorial Sloan Kettering Cancer Center) ; Schadendorf, Dirk (University Hospital Essen (Alemanya)) ; Schein, Jacqueline E. (Canada's Michael Smith Genome Sciences Center. BC Cancer Agency) ; Schmidt, Heather K. (The McDonnell Genome Institute. Washington University) ; Schultz, Nikolaus (Memorial Sloan Kettering Cancer Center) ; Seethala, Raja (University of Pittsburgh) ; Senbabaoglu, Yasin (Memorial Sloan Kettering Cancer Center) ; Shelton, Troy (International Genomics Consortium) ; Shi, Yan (Lineberger Comprehensive Cancer Center. University of North Carolina at Chapel Hill) ; Shih, Juliann (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica). Department of Medical Oncology) ; Shmulevich, Ilya (Institute for Systems Biology) ; Shriver, Craig (Murtha Cancer Center. Walter Reed National Military Medical Center) ; Signoretti, Sabina (Harvard Medical School) ; Simons, Janae V. (Lineberger Comprehensive Cancer Center. University of North Carolina at Chapel Hill) ; Singer, Samuel (Department of Surgery. Memorial Sloan Kettering Cancer Center) ; Sipahimalani, Payal (Canada's Michael Smith Genome Sciences Center. BC Cancer Agency) ; Skelly, Tara J. (Department of Genetics. University of North Carolina at Chapel Hill) ; Smith-McCune, Karen (Department of Obstetrics. Gynecology and Reproductive Services. University of California San Francisco) ; Socci, Nicholas D. (Memorial Sloan Kettering Cancer Center) ; Soloway, Matthew G. (Department of Genetics and Lineberger Comprehensive Cancer Center. University of North Carolina at Chapel Hill) ; Sood, Anil K. (Department of Gynecologic Oncology and Reproductive Medicine. and Center for RNA Interference and Non-Coding RNA. The University of Texas MD Anderson Cancer Center) ; Tam, Angela (Canada's Michael Smith Genome Sciences Center. BC Cancer Agency) ; Tan, Donghui (Department of Genetics. University of North Carolina at Chapel Hill) ; Tarnuzzer, Roy (National Cancer Institute. National Institutes of Health) ; Thiessen, Nina (Canada's Michael Smith Genome Sciences Center. BC Cancer Agency) ; Thompson, R. Houston (Department of Urology. Mayo Clinic) ; Thorne, Leigh B. (University of North Carolina at Chapel Hill) ; Tsao, Ming (University Health Network) ; Umbricht, Christopher (Department of Surgery. Johns Hopkins University School of Medicine) ; Van Den Berg, David J. (USC Norris Comprehensive Cancer Center. University of Southern California) ; Van Meir, Erwin G. (Department of Neurosurgery. Department of Hematology and Department of Medical Oncology. Winship Cancer Institute and School of Medicine. Emory University) ; Veluvolu, Umadevi (Department of Genetics. University of North Carolina at Chapel Hill) ; Voet, Douglas (Broad Institute of MIT and Harvard) ; Wang, Linghua (Human Genome Sequencing Center. Baylor College of Medicine) ; Weinberger, Paul (Georgia Regents University Cancer Center) ; Weisenberger, Daniel J. (USC Norris Comprehensive Cancer Center. University of Southern California) ; Wigle, Dennis (Thoracic Oncology Laboratory. Mayo Clinic) ; Wilkerson, Matthew D. (Department of Genetics. University of North Carolina at Chapel Hill) ; Wilson, Richard K. (Institute for Genomic Medicine. Nationwide Children's Hospital) ; Winterhoff, Boris (Department of Obstetrics & Gynecology. Division of Gynecologic Oncology. Mayo Clinic) ; Wiznerowicz, Maciej (Poznan University of Medical Sciences) ; Wong, Tina (Canada's Michael Smith Genome Sciences Center. BC Cancer Agency) ; Wong, Wing Hing (Edison Family Center for Genome Sciences and Systems Biology. Washington University) ; Xi, Liu (Human Genome Sequencing Center. Baylor College of Medicine) ; Yau, Christina (Buck Institute for Research on Aging) ; Zhang, Hailei (Broad Institute of MIT and Harvard, Cambridge) ; Zhang, Hongxin (Memorial Sloan Kettering Cancer Center) ; Zhang, Junjun (National Cancer Institute. National Institutes of Health)
Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale. Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). [...]
2020 - 10.1038/s41586-020-1969-6
Nature, Vol. 578 (February 2020) , p. 82-93  
10.
12 p, 371.6 KB DNA Glycosylases Involved in Base Excision Repair May Be Associated with Cancer Risk in BRCA1 and BRCA2 Mutation Carriers / Osorio, Ana (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Milne, Roger L. (Cancer Epidemiology Centre (Melbourne, Austràlia)) ; Kuchenbaecker, Karoline (University of Cambridge. Centre for Cancer Genetic Epidemiology) ; Vaclová, Tereza (Centro Nacional de Investigaciones Oncológicas) ; Pita, Guillermo (Centro Nacional de Investigaciones Oncológicas) ; Alonso, Rosario (Centro Nacional de Investigaciones Oncológicas) ; Peterlongo, Paolo (IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy) ; Blanco Guillermo, Ignacio (Institut Català d'Oncologia) ; De la Hoya, Miguel (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ; Durán, Mercedes (Universidad de Valladolid) ; Diez, Orland (Vall d'Hebron Institut d'Oncologia) ; Ramon y Cajal, Teresa (Institut d'Investigació Biomèdica Sant Pau) ; Konstantopoulou, Irene (Molecular Diagnostics Laboratory IRRP, National Centre for Scientific Research Demokritos Aghia Paraskevi Attikis, Athens, Greece) ; Martínez-Bouzas, Cristina (Hospital Universitario de Cruces (Barakaldo, País Basc)) ; Andrés Conejero, Raquel (Hospital Clínico Universitario "Lozano Blesa" de Zaragoza) ; Soucy, Penny (Centre Hospitalier Universitaire de Québec. Cancer Genomics Laboratory) ; McGuffog, Lesley (University of Cambridge. Centre for Cancer Genetic Epidemiology) ; Barrowdale, Daniel (University of Cambridge. Centre for Cancer Genetic Epidemiology) ; Lee, Andrew (University of Cambridge. Centre for Cancer Genetic Epidemiology) ; SWE-BRCA, None (Department of Oncology, Lund University, Lund, Sweden) ; Arver, Brita (Karolinska University Hospital and Karolinska Institutet (Suècia)) ; Rantala, Johanna (Karolinska University Hospital and Karolinska Institutet (Suècia)) ; Loman, Niklas (Department of Oncology, Lund University Hospital, Lund, Sweden) ; Ehrencrona, Hans (Department of Clinical Genetics, Lund University Hospital, Lund, Sweden) ; Olopade, Olufunmilayo I. (Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center, Chicago, Illinois, United States of America) ; Beattie, Mary S. (Departments of Medicine, Epidemiology, and Biostatistics, University of California, San Francisco, San Francisco, California, United States of America) ; Domchek, Susan M. (Abramson Cancer Center and Department of Medicine, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America) ; Nathanson, Katherine (Abramson Cancer Center and Department of Medicine, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America) ; Rebbeck, Timothy R. (Abramson Cancer Center and Center for Clinical Epidemiology and Biostatistics, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America) ; Arun, Banu K. (University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America) ; Karlan, Beth Y. (Cedars Sinai Heart Institute (Los Angeles, Estats Units d'Amèrica)) ; Walsh, Christine (Cedars Sinai Heart Institute (Los Angeles, Estats Units d'Amèrica)) ; Lester, Jenny (Cedars Sinai Heart Institute (Los Angeles, Estats Units d'Amèrica)) ; John, Esther M. (Department of Epidemiology, Cancer Prevention Institute of California, Fremont, California, United States of America) ; Whittemore, Alice S. (Department of Health Research & Policy, Stanford University School of Medicine, Stanford, California, United States of America) ; Daly, Mary B. (Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America) ; Southey, Melissa (Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, Australia) ; Hopper, John L (Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Melbourne, Victoria, Australia) ; Terry, Mary Beth (Department of Epidemiology, Columbia University, New York, New York, United States of America) ; Buys, Saundra (Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, United States of America) ; Janavicius, Ramunas (Vilnius University Hospital Santariskiu Clinics) ; Dorfling, Cecilia M. (Department of Genetics, University of Pretoria, Pretoria, South Africa) ; van Rensburg, Elizabeth J. (Department of Genetics, University of Pretoria, Pretoria, South Africa) ; Steele, Linda (Beckman Research Institute of City of Hope (Duarte, Estats Units d'Amèrica). Department of Population Sciences) ; Neuhausen, Susan L. (Beckman Research Institute of City of Hope (Duarte, Estats Units d'Amèrica). Department of Population Sciences) ; Ding, Yuan Chun (Beckman Research Institute of City of Hope (Duarte, Estats Units d'Amèrica). Department of Population Sciences) ; Hansen, Thomas v. O. (Copenhagen University Hospital Rigshospitalet) ; Jønson, Lars (Copenhagen University Hospital Rigshospitalet) ; Ejlertsen, Bent (Copenhagen University Hospital Rigshospitalet) ; Gerdes, Anne-Marie (Copenhagen University Hospital Rigshospitalet) ; Infante, Mar (Universidad de Valladolid) ; Herráez, Belén (Centro Nacional de Investigaciones Oncológicas) ; Moreno, Leticia Thais (Centro Nacional de Investigaciones Oncológicas) ; Weitzel, Jeffrey N. (Clinical Cancer Genetics, City of Hope, Duarte, California, United States of America) ; Herzog, Josef (Clinical Cancer Genetics, City of Hope, Duarte, California, United States of America) ; Weeman, Kisa (Clinical Cancer Genetics, City of Hope, Duarte, California, United States of America) ; Manoukian, Siranoush (Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy) ; Peissel, Bernard (Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy) ; Zaffaroni, Daniela (Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy) ; Scuvera, Giulietta (Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy) ; Bonanni, Bernardo (Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, Italy) ; Mariette, Frederique (IFOM, Fondazione Istituto FIRC di Oncologia Molecolare and Cogentech Cancer Genetic Test Laboratory, Milan, Italy) ; Volorio, Sara (IFOM, Fondazione Istituto FIRC di Oncologia Molecolare and Cogentech Cancer Genetic Test Laboratory, Milan, Italy) ; Viel, Alessandra (Division of Experimental Oncology 1, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy) ; Varesco, Liliana (Unit of Hereditary Cancer, Department of Epidemiology, Prevention and Special Functions, IRCCS AOU San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy) ; Papi, Laura (Unit of Medical Genetics, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy) ; Ottini, Laura (Department of Molecular Medicine, "Sapienza" University, Rome, Italy) ; Tibiletti, Maria Grazia (UO Anatomia Patologica, Ospedale di Circolo-Università dell'Insubria, Varese, Italy) ; Radice, Paolo (Unit of Molecular bases of genetic risk and genetic testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy) ; Yannoukakos, Drakoulis (Molecular Diagnostics Laboratory IRRP, National Centre for Scientific Research Demokritos Aghia Paraskevi Attikis, Athens, Greece) ; Garber, Judy (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica)) ; Ellis, Steve (University of Cambridge. Centre for Cancer Genetic Epidemiology) ; Frost, Debra (University of Cambridge. Centre for Cancer Genetic Epidemiology) ; Platte, Radka (University of Cambridge. Centre for Cancer Genetic Epidemiology) ; Fineberg, Elena (University of Cambridge. Centre for Cancer Genetic Epidemiology) ; Evans, Gareth (Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom) ; Lalloo, Fiona (Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom) ; Izatt, Louise (Guy's and St Thomas' NHS Foundation Trust (Regne Unit)) ; Eeles, Ros (Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, United Kingdom) ; Adlard, Julian (Yorkshire Regional Genetics Service, Leeds, United Kingdom) ; Davidson, Rosemarie (Ferguson-Smith Centre for Clinical Genetics (Glasgow, Regne Unit)) ; Cole, Trevor (Birmingham Women's Hospital) ; Eccles, Diana M (Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton, United Kingdom) ; Cook, Jackie (Sheffield Children's Hospital (Sheffield, Regne Unit)) ; Hodgson, Shirley (Clinical Genetics Department, St Georges Hospital, University of London, London, United Kingdom) ; Brewer, Carole (Royal Devon & Exeter Hospital (Exeter, Regne Unit)) ; Tischkowitz, Marc (Addenbrookes Hospital (Cambridge, Regne Unit)) ; Douglas, Fiona (Institute of Human Genetics, Centre for Life, Newcastle Upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, United Kingdom) ; Porteous, Mary (South East of Scotland Regional Genetics Service, Western General Hospital, Edinburgh, United Kingdom) ; Side, Lucy (Great Ormond Street Hospital for Children (Londres)) ; Walker, Lisa (Oxford Regional Genetics Service, Churchill Hospital, Oxford, United Kingdom) ; Morrison, Patrick (Northern Ireland Regional Genetics Centre, Belfast City Hospital, Belfast, United Kingdom) ; Donaldson, Alan (South West Regional Genetics Service, Bristol, United Kingdom) ; Kennedy, John (Trinity College Dublin) ; Foo, Claire (Cheshire & Merseyside Clinical Genetics Service, Liverpool Women's NHS Foundation Trust, Liverpool, United Kingdom) ; Godwin, Andrew K. (Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, United States of America) ; Schmutzler, Rita Katharina (University Hospital of Cologne (Colònia, Alemanya). Centre of Familial Breast and Ovarian Cancer and Centre for Integrated Oncology (CIO)) ; Wappenschmidt, Barbara (University Hospital of Cologne (Colònia, Alemanya). Centre of Familial Breast and Ovarian Cancer and Centre for Integrated Oncology (CIO)) ; Rhiem, Kerstin (University Hospital of Cologne (Colònia, Alemanya). Centre of Familial Breast and Ovarian Cancer and Centre for Integrated Oncology (CIO)) ; Engel, Christoph (Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany) ; Meindl, Alfons (Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Munich, Germany) ; Ditsch, Nina (Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Munich, Germany) ; Arnold, Norbert (Department of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany) ; Plendl, Hans Jörg (Institute of Human Genetics, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany) ; Niederacher, Dieter (University Hospital of Düsseldorf (Alemanya)) ; Sutter, Christian (Institute of Human Genetics, Department of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany) ; Wang-Gohrke, Shan (University Hospital of Ulm (Alemanya)) ; Steinemann, Doris (Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany) ; Preisler-Adams, Sabine (Institute of Human Genetics, University of Münster, Münster, Germany) ; Kast, Karin (Department of Gynaecology and Obstetrics, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany) ; Varon-Mateeva, Raymonda (Institute of Human Genetics, Campus Virchov Klinikum, Charite Berlin, Berlin, Germany) ; Gehrig, Andrea (Centre of Familial Breast and Ovarian Cancer, Department of Medical Genetics, Institute of Human Genetics, University Würzburg, Würzburg, Germany) ; Stoppa-Lyonnet, Dominique (Université Paris Descartes, Sorbonne Paris Cité, Paris, France) ; Sinilnikova, Olga M. (Centre National de la Recherche Scientifique (França)) ; Mazoyer, Sylvie (Centre National de la Recherche Scientifique (França)) ; Damiola, Francesca (Centre National de la Recherche Scientifique (França)) ; Poppe, Bruce (Center for Medical Genetics, Ghent University, Ghent, Belgium) ; Claes, Kathleen (Center for Medical Genetics, Ghent University, Ghent, Belgium) ; Piedmonte, Marion (Gynecologic Oncology Group Statistical and Data Center, Roswell Park Cancer Institute, Buffalo, New York, United States of America) ; Tucker, Kathy (Prince of Wales Hospital (Australia)) ; Backes, Floor (Ohio State University, Columbus Cancer Council, Columbus, Ohio, United States of America) ; Rodríguez, Gustavo (Division of Gynecologic Oncology, NorthShore University HealthSystem, Evanston, Illinois, United States of America) ; Brewster, Wendy (Division of Gynecologic Oncology, NorthShore University HealthSystem, Chicago, Illinois, United States of America) ; Wakeley, Katie (For Tufts Medical Center, Boston, Massachusetts, United States of America) ; Rutherford, Thomas (Yale University School of Medicine, New Haven, Connecticut, United States of America) ; Caldes, Trinidad (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ; Nevanlinna, Heli (Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland) ; Aittomäki, Kristiina (Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland) ; Rookus, Matti A. (The Netherlands Cancer Institute (Amsterdam, Països Baixos)) ; van Os, Theo A. M. (Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands) ; van der Kolk, Lizet (The Netherlands Cancer Institute (Amsterdam, Països Baixos)) ; de Lange, J. L. (The Netherlands Cancer Institute (Amsterdam, Països Baixos)) ; Meijers-Heijboer, Hanne E. J. (Amsterdam Universitair Medische Centra (Amsterdam, Països Baixos)) ; van der Hout, A. H. (University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands) ; van Asperen, Christi J. (Department of Clinical Genetics, Leiden University Medical Center Leiden, Leiden, The Netherlands) ; Gómez Garcia, Encarna B. (Department of Clinical Genetics and GROW, School for Oncology and Developmental Biology, MUMC, Maastricht, The Netherlands) ; Hoogerbrugge, Nicoline (Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands) ; Collée, J. Margriet (Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands) ; van Deurzen, Carolien H. M. (Department of Pathology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands) ; van der Luijt, Rob B. (Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands) ; Devilee, Peter (Department of Human Genetics & Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands) ; HEBON, None (The Hereditary Breast and Ovarian Cancer Research Group, Netherlands Cancer Institute, Amsterdam, The Netherlands) ; Olah, Edith (Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary) ; Lázaro, Conxi (Institut d'Investigació Biomèdica de Bellvitge) ; Teulé, Alex (Institut d'Investigació Biomèdica de Bellvitge) ; Menéndez, Mireia (Institut d'Investigació Biomèdica de Bellvitge) ; Jakubowska, Anna (Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland) ; Cybulski, Cezary (Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland) ; Gronwald, Jacek (Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland) ; Lubinski, Jan (Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland) ; Durda, Katarzyna (Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland) ; Jaworska-Bieniek, Katarzyna (Postgraduate School of Molecular Medicine, Warsaw Medical University, Warsaw, Poland) ; Johannsson, Oskar Th. (Landspitali University Hospital (Reykjavík, Islàndia)) ; Maugard, Christine (Laboratoire de Diagnostic Génétique et Service d'Onco-hématologie, Hopitaux Universitaire de Strasbourg, CHRU Nouvel Hôpital Civil, Strasbourg, France) ; Montagna, Marco (Veneto Institute of Oncology (Pàdua, Itàlia)) ; Tognazzo, Silvia (Veneto Institute of Oncology (Pàdua, Itàlia)) ; Teixeira, Manuel R. (Department of Genetics, Portuguese Oncology Institute, Porto, and Biomedical Sciences Institute (ICBAS), Porto University, Porto, Portugal) ; Healey, Sue (Department of Genetics and Computational Biology, Queensland Institute of Medical Research, Brisbane, Australia) ; Investigators, kConFab (Kathleen Cuningham Consortium for Research into Familial Breast Cancer, Peter MacCallum Cancer Center, Melbourne, Australia) ; Olswold, Curtis (Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America) ; Guidugli, Lucia (Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America) ; Lindor, Noralane (Center for Individualized Medicine, Mayo Clinic, Scottsdale, Arizona, United States of America) ; Slager, Susan (Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America) ; Szabo, Csilla I. (Center for Translational Cancer Research, Department of Biological Sciences, University of Delaware, Newark, Delaware, United States of America) ; Vijai, Joseph (Memorial Sloan Kettering Cancer Center) ; Robson, Mark (Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America) ; Kauff, Noah (Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America) ; Zhang, Liying (Diagnostic Molecular Genetics Laboratory, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America) ; Rau-Murthy, Rohini (Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America) ; Fink-Retter, Anneliese (Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria) ; Singer, Christian F. (Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria) ; Rappaport, Christine (Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria) ; Geschwantler Kaulich, Daphne (Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria) ; Pfeiler, Georg (Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria) ; Tea, Muy-Kheng (Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria) ; Berger, Andreas (Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria) ; Phelan, Catherine M. (Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, United States of America) ; Greene, Mark H. (National Cancer Institute (Rockville, Estats Units d'Amèrica)) ; Mai, Phuong L. (National Cancer Institute (Rockville, Estats Units d'Amèrica)) ; Lejbkowicz, Flavio (Clalit National Israeli Cancer Control Center, Haifa, Israel) ; Andrulis, Irene L. (Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada, and Cancer Care Ontario, Departments of Molecular Genetics and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada) ; Mulligan, Anna Marie (University of Toronto) ; Glendon, Gord (Mount Sinai Hospital (Toronto, Canadà)) ; Toland, Amanda Ewart (Division of Human Cancer Genetics, Departments of Internal Medicine and Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America) ; Bojesen, Anders (Department of Clinical Genetics, Vejle Hospital, Vejle, Denmark) ; Pedersen, Inge Sokilde (Aalborg University Hospital (Dinamarca)) ; Sunde, Lone (Aarhus University Hospital (Aarhus, Dinamarca)) ; Thomassen, Mads (Odense University Hospital (Dinamarca)) ; Kruse, Torben A. (Odense University Hospital (Dinamarca)) ; Jensen, Uffe Birk (Aarhus University Hospital (Aarhus, Dinamarca)) ; Friedman, Eitan (Sheba Medical Center, Tel Aviv, Israel) ; Laitman, Yael (Sheba Medical Center, Tel Aviv, Israel) ; Shimon, Shani Paluch (Sheba Medical Center, Tel Aviv, Israel) ; Simard, Jacques (Canada Research Chair in Oncogenetics, Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Quebec City, Canada) ; Easton, Douglas F. (University of Cambridge. Centre for Cancer Genetic Epidemiology) ; Offit, Kenneth (Memorial Sloan Kettering Cancer Center) ; Couch, Fergus J. (Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America) ; Chenevix-Trench, Georgia (Department of Genetics and Computational Biology, Queensland Institute of Medical Research, Brisbane, Australia) ; Antoniou, Antonis C. (University of Cambridge. Centre for Cancer Genetic Epidemiology) ; Benitez, Javier (Centro Nacional de Investigaciones Oncológicas) ; Universitat Autònoma de Barcelona
Single Nucleotide Polymorphisms (SNPs) in genes involved in the DNA Base Excision Repair (BER) pathway could be associated with cancer risk in carriers of mutations in the high-penetrance susceptibility genes BRCA1 and BRCA2, given the relation of synthetic lethality that exists between one of the components of the BER pathway, PARP1 (poly ADP ribose polymerase), and both BRCA1 and BRCA2. [...]
2014 - 10.1371/journal.pgen.1004256
PLoS Genetics, Vol. 10 (april 2014)  

Articles : 12 registres trobats   1 - 10següent  anar al registre:
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