Resultats globals: 9 registres trobats en 0.02 segons.
Articles, 9 registres trobats
Articles 9 registres trobats  
1.
17 p, 2.5 MB Dissemination of Mycobacterium tuberculosis is associated to a SIGLEC1 null variant that limits antigen exchange via trafficking extracellular vesicles / Benet, Susana (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Gálvez, Cristina (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Drobniewski, Francis (Imperial College) ; Kontsevaya, Irina (N.V. Postnikov Samara Region Clinical Tuberculosis Dispensary) ; Arias, Lilibeth (Institut Germans Trias i Pujol) ; Monguió-Tortajada, Marta (Universitat Autònoma de Barcelona) ; Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Urrea, Víctor (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Ong, Ruo-Yan (University of Dundee) ; Luquín Fernández, M (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Dupont, Maeva (International associated laboratory (LIA) CNRS "IM-TB/HIV" (1167)) ; Chojnacki, Jakub (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Dalmau, Judith (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Cardona, Paula (Institut Germans Trias i Pujol) ; Neyrolles, Olivier (International associated laboratory (LIA) CNRS "IM-TB/HIV" (1167)) ; Lugo-Villarino, Geanncarlo (International associated laboratory (LIA) CNRS "IM-TB/HIV" (1167)) ; Vérollet, Christel (International associated laboratory (LIA) CNRS "IM-TB/HIV" (1167)) ; Julián Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Furrer, Hansjakob (University of Bern) ; Günthard, Huldrych F. (University of Zurich) ; Crocker, Paul R. (University of Dundee) ; Tapia Melendo, Gustavo (Institut Germans Trias i Pujol) ; Borràs, Francesc E (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Fellay, Jacques (Lausanne University Hospital and University of Lausanne) ; McLaren, Paul J. (University of Manitoba) ; Telenti, Amalio (The Scripps Research Institute) ; Cardona, Pere-Joan (Institut Germans Trias i Pujol) ; Pérez-Álvarez, Núria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Vilaplana, Cristina (Institut Germans Trias i Pujol) ; Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Izquierdo Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
The identification of individuals with null alleles enables studying how the loss of gene function affects infection. We previously described a non-functional variant in SIGLEC1, which encodes the myeloid-cell receptor Siglec-1/CD169 implicated in HIV-1 cell-to-cell transmission. [...]
2021 - 10.1002/jev2.12046
Journal of extracellular vesicles, Vol. 10 (january 2021)  
2.
13 p, 912.5 KB Siglec-1 Is a Novel Dendritic Cell Receptor That Mediates HIV-1 Trans -Infection Through Recognition of Viral Membrane Gangliosides / Izquierdo-Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Lorizate, Maier (Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany) ; Puertas, Maria C. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Rodriguez-Plata, Maria T. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Zangger, Nadine (Institute of Microbiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland) ; Erikson, Elina (Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany) ; Pino, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Glass, Bärbel (Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany) ; Clotet, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Keppler, Oliver T. (Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany) ; Telenti, Amalio (Institute of Microbiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland) ; Kräusslich, Hans-Georg (Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany) ; Martinez-Picado, Javier (Institució Catalana de Recerca i Estudis Avançats (ICREA)) ; Universitat Autònoma de Barcelona
The novel dendritic cell receptor Siglec-1 binds sialyllactose moieties on HIV-1 membrane gangliosides, thereby enhancing HIV-1 transinfection. Dendritic cells (DCs) are essential antigen-presenting cells for the induction of immunity against pathogens. [...]
2012 - 10.1371/journal.pbio.1001448
PLoS biology, Vol. 10 (december 2012)  
3.
10 p, 2.9 MB Role of Human Organic Cation Transporter 1 (hOCT1) Polymorphisms in Lamivudine (3TC) Uptake and Drug-Drug Interactions / Arimany-Nardi, Cristina (Instituto de Salud Carlos III) ; Minuesa, Gerard (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Keller, Thorsten (Department of Pharmacology, School of Medicine, University of Würzburg) ; Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Koepsell, Hermann (Department of Molecular Plant Physiology and Biophysics, Julius-von-Sachs-Institute, University of Würzburg) ; Martinez-Picado, Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Pastor-Anglada, Marçal (Institut de Recerca Sant Joan de Déu) ; Universitat Autònoma de Barcelona
Lamivudine (3TC), a drug used in the treatment of HIV infection, needs to cross the plasma membrane to exert its therapeutic action. Human Organic cation transporter 1 (hOCT1), encoded by the SLC22A1 gene, is the transporter responsible for its uptake into target cells. [...]
2016 - 10.3389/fphar.2016.00175
Frontiers in Pharmacology, Vol. 7 (june 2016)  
4.
11 p, 635.6 KB P-glycoprotein (ABCB1) activity decreases raltegravir disposition in primary CD4+P-gp high cells and correlates with HIV-1 viral load / Minuesa Dinarés, Gerard (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Arimany-Nardi, Cristina (National Biomedical Research Institute on Liver and Gastrointestinal Diseases (CIBER EHD), Instituto de Salud Carlos III) ; Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Cedeño, Samandhy (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Moltó Marhuenda, José (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ; Clotet, Bonaventura (Institució Catalana de Recerca i Estudis Avançats (ICREA)) ; Pastor-Anglada, Marçal (National Biomedical Research Institute on Liver and Gastrointestinal Diseases (CIBER EHD), Instituto de Salud Carlos III) ; Martínez Picado, Francisco Javier (Universitat de Vic, Universitat Central de Catalunya (UVic-UCC))
To evaluate the role of P-glycoprotein (P-gp) and multidrug-resistant-protein 1 (MRP1) on raltegravir intracellular drug disposition in CD4+ T cells, investigate the effect of HIV-1 infection on P-gp expression and correlate HIV-1 viraemia with P-gp activity in primary CD4+ T cell subsets. [...]
2016 - 10.1093/jac/dkw215
Journal of Antimicrobial Chemotherapy, Vol. 71 (june 2016) , p. 2782-2792  
5.
16 p, 1.9 MB The infectious synapse formed between mature dendritic cells and CD4 + T cells is independent of the presence of the HIV-1 envelope glycoprotein / Rodriguez-Plata, Maria T (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Puigdomènech, Isabel (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Izquierdo-Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Puertas, Maria C (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Carrillo, Jorge (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Clotet, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Blanco, Julià (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Martinez-Picado, Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Universitat Autònoma de Barcelona
Since cell-mediated infection of human immunodeficiency virus type 1 (HIV-1) is more efficient than cell-free infection, cell-to-cell propagation plays a crucial role in the pathogenesis of HIV-1 infection. [...]
2013 - 10.1186/1742-4690-10-42
Retrovirology, Vol. 10 (april 2013) , p. 42  
6.
15 p, 1.4 MB Sialyllactose in Viral Membrane Gangliosides Is a Novel Molecular Recognition Pattern for Mature Dendritic Cell Capture of HIV-1 / Izquierdo Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Lorizate, Maier (Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany) ; Contreras, F. Xabier (Heidelberg University Biochemistry Center (BZH), Heidelberg) ; Rodríguez Plata, María T. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Glass, Bärbel (Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany) ; Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Prado, Julia G. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Casas, Josefina (Department of Biomedicinal Chemistry, Institute of Advanced Chemistry of Catalonia (IQAC)/CSIC, Barcelona, Spain) ; Fabriàs, Gemma (Department of Biomedicinal Chemistry, Institute of Advanced Chemistry of Catalonia (IQAC)/CSIC, Barcelona, Spain) ; Kräusslich, Hans Georg (Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany) ; Martínez Picado, Francisco Javier (Institució Catalana de Recerca i Estudis Avançats (ICREA))
An accessible sialyllactose moiety on viral membrane gangliosides is shown to be essential for HIV-1 uptake into mature dendritic cells, thereby promoting viral transfer and infection of bystander CD4+ T lymphocytes. [...]
2012 - 10.1371/journal.pbio.1001315
PLoS biology, Vol. 10 (april 2012)  
7.
7 p, 617.5 KB Identification of Siglec-1 null individuals infected with HIV-1 / Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; McLaren, Paul J. (National HIV and Retrovirology Laboratory (Winnipeg, Canadà)) ; Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Martin, Maureen P. (Frederick National Laboratory for Cancer Research (Maryland, Estats Units d'Amèrica)) ; Benet, Susana (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Rotger, Margalida (University of Lausanne (Suïssa)) ; Dalmau, Judith (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Ouchi, Dan (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Wolinsky, Steven M. (Northwestern University Feinberg School of Medicine (Chicago, Estats Units d'Amèrica)) ; Penugonda, Sudhir (Northwestern University Feinberg School of Medicine (Chicago, Estats Units d'Amèrica)) ; Günthard, Huldrych F. (University Hospital Zurich (Suïssa)) ; Fellay, Jacques (École Polytechnique Fédérale de Lausanne (Suïssa)) ; Carrington, Mary (Frederick National Laboratory for Cancer Research (Maryland, Estats Units d'Amèrica)) ; Izquierdo Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Telenti, Amalio (J. Craig Venter Institute (La Jolla, Estats Units d'Amèrica))
Siglec-1/CD169 is a myeloid-cell surface receptor critical for HIV-1 capture and infection of bystander target cells. To dissect the role of SIGLEC1 in natura, we scan a large population genetic database and identify a loss-of-function variant (Glu88Ter) that is found in ∼1% of healthy people. [...]
2016 - 10.1038/ncomms12412
Nature communications, Vol. 7 Núm. 12412 (August 2016)  
8.
15 p, 3.1 MB HIV-1 immune activation induces Siglec-1 expression and enhances viral trans-infection in blood and tissue myeloid cells / Pino, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Benet, Susana (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Erikson, Elina (University of Frankfurt (Alemanya)) ; Fernández Figueras, Maria Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Guerrero, Dolores (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Dalmau, Judith (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Ouchi, Dan (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Rausell, Antonio (University of Lausanne (Suïssa)) ; Ciuffi, Angela (University of Lausanne (Suïssa)) ; Keppler, Oliver T. (University of Frankfurt (Alemanya)) ; Telenti, Amalio (University of Lausanne (Suïssa)) ; Kräusslich, Hans-Georg (University of Heidelberg (Alemanya)) ; Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Izquierdo Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Universitat Autònoma de Barcelona
Myeloid cells are key players in the recognition and response of the host against invading viruses. Paradoxically, upon HIV-1 infection, myeloid cells might also promote viral pathogenesis through trans-infection, a mechanism that promotes HIV-1 transmission to target cells via viral capture and storage. [...]
2015 - 10.1186/s12977-015-0160-x.
Retrovirology, Vol 12, article 37 (May 2015)  
9.
9 p, 5.6 MB HIV and mature dendritic cells : Trojan exosomes riding the Trojan horse? / Izquierdo Useros, Nuria (IrsiCaixa Foundation) ; Naranjo-Gómez, Mar (Institut Germans Trias i Pujol) ; Erkizia, Itziar (IrsiCaixa Foundation) ; Puertas, María Carmen (IrsiCaixa Foundation) ; Borràs, Francesc E (Institut Germans Trias i Pujol) ; Blanco, Julià (IrsiCaixa Foundation) ; Martínez Picado, Francisco Javier (Institució Catalana de Recerca i Estudis Avançats)
Exosomes are secreted cellular vesicles that can induce specific CD4+ T cell responses in vivo when they interact with competent antigen-presenting cells like mature dendritic cells (mDCs). The Trojan exosome hypothesis proposes that retroviruses can take advantage of the cell-encoded intercellular vesicle traffic and exosome exchange pathway, moving between cells in the absence of fusion events in search of adequate target cells. [...]
2010 - 10.1371/journal.ppat.1000740
PLoS pathogens, Vol. 6, Issue 3 (March 2010) , p. e1000740  

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