Resultats globals: 8 registres trobats en 0.02 segons.
Articles, 8 registres trobats
Articles 8 registres trobats  
1.
12 p, 783.3 KB Genetic correlation between amyotrophic lateral sclerosis and schizophrenia / McLaughlin, Russell L. (Trinity College Dublin) ; Schijven, Dick (University Medical Center Utrecht) ; van Rheenen, Wouter (University Medical Center Utrecht) ; Van Eijk, Kristel R. (University Medical Center Utrecht) ; O'Brien, Margaret (Trinity College Dublin) ; Kahn, René S. (University Medical Center Utrecht) ; Ophoff, Roel A. (University of California) ; Goris, An (KU Leuven-University of Leuven) ; Bradley, Daniel G. (Trinity College Dublin) ; Al-Chalabi, Ammar (King's College London) ; van den Berg, Leonard H. (University Medical Center Utrecht) ; Luykx, Jurjen J. (Hospital Network Antwerp (ZNA). Stuivenberg and Sint Erasmus) ; Hardiman, Orla (Trinity College Dublin) ; Veldink, Jan (University Medical Center Utrecht) ; Shatunov, Aleksey (King's College London) ; Dekker, Annelot M. (University Medical Center Utrecht) ; Diekstra, Frank P. (University Medical Center Utrecht) ; Pulit, Sara L. (University Medical Center Utrecht) ; van der Spek, Rick A.A. (University Medical Center Utrecht) ; van Doormaal, Perry TC. (University Medical Center Utrecht) ; Sproviero, William (King's College London) ; Jones, Ashley R. (King's College London) ; Nicholson, Garth A. (University of Sydney) ; Rowe, Dominic B. (Macquarie University) ; Pamphlett, Roger (University of Sydney) ; Kiernan, Matthew C. (University of Sydney) ; Bauer, Denis (Commonwealth Scientific and Industrial Research Organisation) ; Kahlke, Tim (Commonwealth Scientific and Industrial Research Organisation) ; Williams, Kelly (Macquarie University) ; Eftimov, Filip (Academic Medical Center) ; Fogh, Isabella (IRCCS Istituto Auxologico Italiano) ; Ticozzi, Nicola (Università degli Studi di Milano) ; Lin, Kuang (King's College London) ; Millecamps, Stéphanie (Institut du Cerveau et de la Moelle Épinière) ; Salachas, François (Ramsay Generale de Santé) ; Meininger, Vincent (Ramsay Generale de Santé) ; de Carvalho, Mamede (Hospital de Santa Maria (Lisboa)) ; Pinto, Susana (Hospital de Santa Maria (Lisboa)) ; Mora, Jesús S. (Hospital Carlos III) ; Rojas-Garcia, Ricard (Institut d'Investigació Biomèdica Sant Pau) ; Polak, Meraida (Emory University) ; Chandran, Siddharthan (University of Edinburgh) ; Colville, Shuna (Euan MacDonald Centre for Motor Neurone Disease Research) ; Swingler, Robert (Euan MacDonald Centre for Motor Neurone Disease Research) ; Morrison, Karen E. (Queen Elizabeth Hospital) ; Shaw, Pamela (University of Sheffield) ; Hardy, John (University College London) ; Orrell, Richard W. (University College London) ; Pittman, Alan (University College London) ; Sidle, Katie (University College London) ; Fratta, Pietro (University College London) ; Malaspina, Andrea (Motor Neuron Disease Care Centre) ; Petri, Susanne (Medical School Hannover) ; Abdulla, Susanne (Otto-von-Guericke University Magdeburg) ; Drepper, Carsten (University of Würzburg) ; Sendtner, Michael (University of Würzburg) ; Meyer, Thomas (Charité University Hospital) ; Wiedau-Pazos, Martina (University of California) ; Lomen-Hoerth, Catherine (University of California) ; van Deerlin, Vivianna M. (University of Pennsylvania) ; Trojanowski, John Q. (University of Pennsylvania) ; Elman, Lauren B. (University of Pennsylvania) ; McCluskey, Leo (University of Pennsylvania) ; Basak, Nazli (Bogazici University) ; Meitinger, Thomas (Helmholtz Zentrum München) ; Lichtner, Peter (Helmholtz Zentrum München) ; Blagojevic-Radivojkov, Milena (Helmholtz Zentrum München) ; Andres, Christian R. (Université François Rabelais) ; Maurel, Cindy (Université François Rabelais) ; Bensimon, Gilbert (Hôpital de la Pitié-Salpêtrière) ; Landwehrmeyer, Georg Bernhard (Ulm University) ; Brice, Alexis (Sorbonne Universités) ; Payan, Christine A. M. (Hôpital de la Pitié-Salpêtrière) ; Saker-Delye, Safa (Genethon. CNRS UMR 8587) ; Durr, Alexandra (Hoptial Salpêtrière) ; Wood, Nicholas (University College London) ; Tittmann, Lukas (Christian Albrechts-University Kiel) ; Lieb, Wolfgang (Christian Albrechts-University Kiel) ; Franke, Andre (Kiel University) ; Rietschel, Marcella (Central Institute of Mental Health) ; Cichon, Sven (Research Center Juelich) ; Nothen, Markus M. (Life and Brain Center) ; Amouyel, Philippe (Institut Pasteur de Lille) ; Tzourio, Christophe (Pole de Sante Publique) ; Dartigues, Jean- François (Pole de Sante Publique) ; Uitterlinden, André G. (Erasmus Medical Center Rotterdam) ; Rivadeneira, Fernando (Erasmus Medical Center Rotterdam) ; Estrada, Karol (Erasmus Medical Center Rotterdam) ; Hofman, Albert (Erasmus Medical Center Rotterdam) ; Curtis, Charles (King's College London) ; van der kooi, Anneke Jelly (Academic Medical Center) ; de Visser, Marianne (Academic Medical Center) ; Weber, Markus (ALS Clinic) ; Shaw, Christopher (King's College London) ; Smith, B.N. (King's College London) ; Pansarasa, O. (IRCCS 'C. Mondino' National Institute) ; Cereda, C. (IRCCS 'C. Mondino' National Institute) ; Bo, R.D. (IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico) ; Comi, G.P. (IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico) ; D'Alfonso, S. (Università Del Piemonte Orientale) ; Bertolin, C. (University of Padova) ; Soraru, G. (University of Padova) ; Mazzini, L. (University of Eastern Piedmont) ; Pensato, V. (Fondazione IRCCS Istituto Neurologico 'Carlo Besta') ; Gellera, C. (Fondazione IRCCS Istituto Neurologico 'Carlo Besta') ; Tiloca, C. (IRCCS Istituto Auxologico Italiano) ; Ratti, A. (Università degli Studi di Milano) ; Calvo, A. (Azienda Ospedaliera Città della Salute e della Scienza) ; Moglia, C. (Azienda Ospedaliera Città della Salute e della Scienza) ; Brunetti, M. (Azienda Ospedaliera Città della Salute e della Scienza) ; Arcuti, S. (University of Bari 'A. Moro') ; Capozzo, Rosa (University of Bari 'A. Moro') ; Zecca, C. (University of Bari 'A. Moro') ; Lunetta, C. (Niguarda Ca' Granda Hostipal) ; Penco, S. (Niguarda Ca' Granda Hospital) ; Riva, N. (San Raffaele Scientific Institute) ; Padovani, A. (University Hospital 'Spedali Civili') ; Filosto, M. (University Hospital 'Spedali Civili') ; Blair, I. (Macquarie University) ; Nigel Leigh, P. (Brighton and Sussex Medical School) ; Casale, F. ('Rita Levi Montalcini') ; Chio, A. (Azienda Ospedaliera Città della Salute e della Scienza) ; Beghi, E. (IRCCS Istituto di Ricerche Farmacologiche Mario Negri) ; Pupillo, E. (IRCCS Istituto di Ricerche Farmacologiche Mario Negri) ; Tortelli, R. (University of Bari 'A. Moro') ; Logroscino, G. (University of Bari 'Aldo Moro') ; Powell, J. (King's College London) ; Ludolph, A.C. (Ulm University) ; Weishaupt, J.H. (Ulm University) ; Robberecht, W. (University Hospital Leuven) ; Damme, P.V. (VIB-Vesalius Research Center) ; Brown, R. H. (University of Massachusetts Medical School) ; Glass, J. (Emory University) ; Landers, J.E. (University of Massachusetts Medical School) ; Andersen, P.M. (Umeå University) ; Corcia, P. (Federation des Centres SLA Tours and Limoges) ; Vourc'H, P. (Université François Rabelais) ; Silani, V. (Università degli Studi di Milano) ; Es, M.A.V. (University Medical Center Utrecht) ; Pasterkamp, R.J. (University Medical Center Utrecht) ; Lewis, C.M. (King's College London) ; Breen, G. (King's College London) ; Ripke, S. (Broad Institute of MI.T. and Harvard) ; Neale, B.M. (Massachusetts General Hospital) ; Corvin, A. (Trinity College) ; Walters, J.T.R. (Cardiff University) ; Farh, K.H. (Massachusetts General Hospital) ; Holmans, P.A. (Cardiff University) ; Lee, P. (Massachusetts General Hospital) ; Bulik-Sullivan, B. (Broad Institute of MI.T. and Harvard) ; Collier, D.A. (King's College London) ; Huang, H. (Broad Institute of MI.T. and Harvard) ; Pers, T.H. (Boston Children's Hospital (Boston, Estats Units d'Amèrica)) ; Agartz, I. (University of Oslo) ; Agerbo, E. (Lundbeck Foundation Initiative for Integrative Psychiatric Research) ; Albus, M. (State Mental Hospital) ; Alexander, M. (Stanford University) ; Amin, F. (Emory University) ; Bacanu, S.A. (Virginia Commonwealth University) ; Begemann, M. (Max Planck Institute of Experimental Medicine) ; Belliveau, R.A. (Broad Institute of MI.T. and Harvard) ; Bene, J. (University of Pécs) ; Bergen, Sarah E. (Karolinska Institutet (Estocolm, Suècia)) ; Bevilacqua, E. (Broad Institute of MI.T. and Harvard) ; Bigdeli, Tim B (Virginia Commonwealth University) ; Black, D.W. (University of Iowa) ; Bruggeman, R. (University Medical Center Groningen) ; Buccola, N.G. (Louisiana State University Health Sciences Center) ; Buckner, R.L. (Massachusetts General Hospital) ; Byerley, W. (University of California at San Francisco) ; Cahn, W. (University Medical Center Utrecht) ; Cai, G. (Icahn School of Medicine at Mount Sinai) ; Campion, D. (Centre Hospitalier du Rouvray) ; Cantor, R.M. (University of California) ; Carr, Vaughan J (University of New South Wales) ; Carrera, N. (Cardiff University) ; Catts, S.V. (University of Queensland) ; Chambert, K.D. (Broad Institute of MI.T. and Harvard) ; Chan, R.C.K. (Chinese Academy of Science) ; Chan, R.Y.L. (University of Hong Kong) ; Chen, E.Y.H. (University of Hong Kong) ; Cheng, W. (University of North Carolina) ; Cheung, E.F.C. (Castle Peak Hospital) ; Chong, S.A. (Institute of Mental Health) ; Cloninger, C.R. (Washington University) ; Cohen, D. (Brain and Spinal Cord Institute (ICM)) ; Cohen, N. (Janssen Research and Development. LLC) ; Cormican, P. (Trinity College) ; Craddock, N. (Cardiff University) ; Crowley, J.J. (University of North Carolina) ; Curtis, D. (University College London) ; Davidson, M. (Sheba Medical Center) ; Davis, K.L. (Icahn School of Medicine at Mount Sinai) ; Degenhardt, F. (Life and Brain Center) ; Favero, J.D. (University of Antwerp) ; Demontis, D. (Aarhus University) ; Dikeos, D. (University of Athens Medical School) ; Dinan, T. (University College Cork) ; Djurovic, S. (Oslo University Hospital) ; Donohoe, G. (National University of Ireland) ; Drapeau, E. (Icahn School of Medicine at Mount Sinai) ; Duan, J. (NorthShore University HealthSystem) ; Dudbridge, F. (London School of Hygiene and Tropical Medicine) ; Durmishi, N. (University Clinic of Psychiatry) ; Eichhammer, P. (University of Regensburg) ; Eriksson, J. (National Institute for Health and Welfare) ; Escott-Price, V. (Cardiff University) ; Essioux, L. (Pharma Research and Early Development) ; Fanous, A.H. (Washington V.A. Medical Center) ; Farrell, M.S. (University of North Carolina) ; Frank, J. (University of Heidelberg) ; Franke, L. (University Medical Centre Groningen) ; Freedman, R. (University of Colorado Denver) ; Freimer, N.B. (University of California) ; Friedl, M. (University of Halle) ; Friedman, J.I. (Icahn School of Medicine at Mount Sinai) ; Fromer, M. (Icahn School of Medicine at Mount Sinai) ; Genovese, G. (Broad Institute of MI.T. and Harvard) ; Georgieva, L. (Cardiff University) ; Giegling, I. (University of Munich) ; Giusti-Rodrýguez, P. (University of North Carolina) ; Godard, S. (Hôpital de la Pitiè-Salpêtrière) ; Goldstein, J.I. (Broad Institute of MI.T. and Harvard) ; Golimbet, V. (Russian Academy of Medical Sciences) ; Gopal, S. (Janssen Research and Development. LLC) ; Gratten, J. (University of Queensland) ; De Haan, L. (University of Amsterdam) ; Hammer, C. (Max Planck Institute of Experimental Medicine) ; Hamshere, M.L. (Cardiff University) ; Hansen, M. (Illumina. Inc.) ; Hansen, T. (Institute of Biological Psychiatry) ; Haroutunian, V. (JJ Peters V.A. Medical Center) ; Hartmann, A.M. (University of Halle) ; Henskens, F.A. (University of Newcastle) ; Herms, S. (University of Basel) ; Hirschhorn, J.N. (Harvard Medical School) ; Hoffmann, P. (University of Basel) ; Hofman, A. (Erasmus Medical Center Rotterdam) ; Hollegaard, M.V. (Statens Serum Institut) ; Hougaard, D.M. (Statens Serum Institut) ; Ikeda, M. (Fujita Health University) ; Joa, I. (Stavanger University Hospital) ; Julia, Antonio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Kalaydjieva, L. (University of Western Australia) ; Karachanak-Yankova, S. (Medical University) ; Karjalainen, J. (University Medical Centre Groningen) ; Kavanagh, D. (Cardiff University) ; Keller, M.C. (University of Colorado Boulder) ; Kennedy, J.L. (University of Toronto) ; Khrunin, A. (Russian Academy of Sciences) ; Kim, Y. (University of North Carolina) ; Klovins, J. (Latvian Biomedical Research and Study Centre) ; Knowles, J.A. (University of Southern California) ; Konte, B. (University of Halle) ; Kucinskas, V. (Vilnius University) ; Kucinskiene, Z.A. (Vilnius University) ; Kuzelova-Ptackova, H. (Charles University Prague) ; Kahler, A.K. (Karolinska Institutet (Estocolm, Suècia)) ; Laurent, C. (Pierre and Marie Curie Faculty of Medicine) ; Lee, J. (Duke-NUS Graduate Medical School) ; Hong Lee, S. (University of Queensland) ; Legge, S.E. (Cardiff University) ; Lerer, B. (Hadassah-Hebrew University Medical Center) ; Li, M. (University of Hong Kong) ; Li, T. (Sichuan University) ; Liang, K.Y. (Bloomberg School of Public Health) ; Lieberman, J. (Columbia University) ; Limborska, S. (Russian Academy of Sciences) ; Loughland, C.M. (University of Newcastle) ; Lubinski, J. (Pomeranian Medical University in Szczecin) ; Lonnqvist, J. (National Institute for Health and Welfare) ; MacEk, M. (Charles University Prague) ; Magnusson, P.K.E. (Karolinska Institutet (Estocolm, Suècia)) ; Maher, B.S. (Johns Hopkins University) ; Maier, W. (University of Bonn) ; Mallet, J. (Hôpital de la Pitié Salpêtrière) ; Marsal, Sara (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Mattheisen, M. (University of Bonn) ; Mattingsdal, M. (Sørlandet Hospital) ; McCarley, R.W. (Virginia Boston Health Care System) ; McDonald, C. (National University of Ireland) ; McIntosh, A.M. (University of Edinburgh) ; Meier, S. (University of Heidelberg) ; Meijer, C.J. (University of Amsterdam) ; Melegh, B. (University of Pécs) ; Melle, I. (Oslo University Hospital) ; Mesholam-Gately, R.I. (Beth Israel Deaconess Medical Center) ; Metspalu, A. (University of Tartu) ; Michie, P.T. (University of Newcastle) ; Milani, L. (University of Tartu) ; Milanova, V. (First Psychiatric Clinic) ; Mokrab, Y. (Eli Lilly and Company Limited) ; Morris, D.W. (National University of Ireland) ; Mors, O. (Aarhus University Hospital (Aarhus, Dinamarca)) ; Murphy, K.C. (Royal College of Surgeons in Ireland) ; Murray, R.M. (King's College London) ; Myin-Germeys, I. (Maastricht University Medical Centre) ; Muller-Myhsok, B. (Munich Cluster for Systems Neurology (SyNergy)) ; Nelis, M. (University of Tartu) ; Nenadic, I. (Jena University Hospital) ; Nertney, D.A. (University of Queensland) ; Nestadt, G. (Johns Hopkins University) ; Nicodemus, K.K. (Trinity College Dublin) ; Nikitina-Zake, L. (Latvian Biomedical Research and Study Centre) ; Nisenbaum, L. (Lilly Corporate Center) ; Nordin, A. (Umeå University) ; O'Callaghan, E. (Early Intervention Service for Psychosis) ; O'Dushlaine, C. (Broad Institute of MI.T. and Harvard) ; Anthony O'Neill, F. (Queens University Belfast) ; Oh, S.Y. (University of California at Berkeley) ; Olincy, A. (University of Colorado Denver) ; Olsen, L. (Institute of Biological Psychiatry) ; Vanos, J. (King's College London) ; Pantelis, C. (University of Melbourne and Melbourne Health) ; Papadimitriou, G.N. (University of Athens Medical School) ; Papiol, S. (Max Planck Institute of Experimental Medicine) ; Parkhomenko, E. (Icahn School of Medicine at Mount Sinai) ; Pato, M.T. (University of Southern California) ; Paunio, T. (National Institute for Health and Welfare) ; Pejovic-Milovancevic, M. (University of Belgrade) ; Perkins, D.O. (University of North Carolina) ; Pietilainen, O. (Institute for Molecular Medicine Finland) ; Pimm, J. (University College London) ; Pocklington, A.J. (Cardiff University) ; Price, A. (Harvard University) ; Pulver, A.E. (Johns Hopkins University) ; Purcell, S.M. (Icahn School of Medicine at Mount Sinai) ; Quested, D. (University of Oxford) ; Rasmussen, H.B. (Institute of Biological Psychiatry) ; Reichenberg, A. (Icahn School of Medicine at Mount Sinai) ; Reimers, M.A. (Virginia Commonwealth University) ; Richards, A.L. (Cardiff University) ; Roffman, J.L. (Massachusetts General Hospital) ; Roussos, P. (Icahn School of Medicine at Mount Sinai) ; Ruderfer, D.M. (Icahn School of Medicine at Mount Sinai) ; Salomaa, V. (National Institute for Health and Welfare) ; Sanders, A.R. (NorthShore University HealthSystem) ; Schall, U. (University of Newcastle) ; Schubert, C.R. (Pfizer Worldwide Research and Development) ; Schulze, T.G. (University of Gottingen) ; Schwab, S.G. (University of Erlangen) ; Scolnick, E.M. (Broad Institute of MI.T. and Harvard) ; Scott, R.J. (University of Newcastle) ; Seidman, L.J. (Beth Israel Deaconess Medical Center) ; Shi, J. (National Cancer Institute) ; Sigurdsson, E. (University of Iceland) ; Silagadze, T. (Tbilisi State Medical University (TSMU)) ; Silverman, J.M. (Bronx Veterans Affairs Medical Center) ; Sim, K. (Institute of Mental Health) ; Slominsky, P. (Russian Academy of Sciences) ; Smoller, J.W. (Massachusetts General Hospital) ; So, H.C. (University of Hong Kong) ; Spencer, C.C.A. (Wellcome Trust Centre for Human Genetics) ; Stah, E.A. (Icahn School of Medicine at Mount Sinai) ; Stefansson, H. (DeCODE Genetics) ; Steinberg, S. (DeCODE Genetics) ; Stogmann, E. (Medical University of Vienna) ; Straub, R.E. (Lieber Institute for Brain Development) ; Strengman, E. (University Medical Centre Utrecht) ; Strohmaier, J. (University of Heidelberg) ; Scott Stroup, T. (Columbia University) ; Subramaniam, M. (Institute of Mental Health) ; Suvisaari, J. (Institute for Health and Welfare) ; Svrakic, D.M. (Washington University) ; Szatkiewicz, J.P. (University of North Carolina) ; Söderman, E. (Karolinska Institutet (Estocolm, Suècia)) ; Thirumalai, S. (Berkshire Healthcare NH.S. Foundation Trust) ; Toncheva, D. (Medical University) ; Tosato, S. (University of Verona) ; Veijola, J. (University Hospital of Oulu) ; Waddington, J. (Royal College of Surgeons in Ireland) ; Walsh, D. (Health Research Board) ; Wang, D. (Janssen Research and Development) ; Wang, Q. (Sichuan University) ; Webb, B.T. (Virginia Commonwealth University) ; Weiser, Mark (Sheba Medical Center) ; Wildenauer, Dieter B. (Queen Elizabeth I.I. Medical Centre) ; Williams, Nigel M. (Cardiff University) ; Williams, Stephanie (University of North Carolina) ; Witt, Stephanie H. (University of Heidelberg) ; Wolen, Aaron R. (Virginia Commonwealth University) ; Wong, Emily H. M. (University of Hong Kong) ; Wormley, Brandon K. (Virginia Commonwealth University) ; Xi, Hualin S. (Pfizer Worldwide Research and Development) ; Zai, Clement C. (University of Toronto) ; Zheng, Xuebin (Genome Institute of Singapore) ; Zimprich, Fritz (University of Vienna) ; Wray, Naomi R. (University of Queensland) ; Stefánsson, Kári (DeCODE Genetics) ; Visscher, P.M. (University of Queensland) ; Adolfsson, Rolf (Umeå University) ; Andreassen, Ole A. (Oslo University Hospital) ; Blackwood, Douglas H. R. (University of Edinburgh) ; Bramon, Elvira (University College London) ; Buxbaum, Joseph D. (Icahn School of Medicine at Mount Sinai) ; Børglum, Anders D. (Aarhus University Hospital (Aarhus, Dinamarca)) ; Darvasi, Ariel (Hebrew University of Jerusalem) ; Domenici, Enrico (F. Hoffman-La Roche) ; Ehrenreich, Hannelore (Max Planck Institute of Experimental Medicine) ; Esko, Tõnu (University of Tartu) ; Gejman, Pablo V. (NorthShore University HealthSystem) ; Gil, Michael (Trinity College) ; Gurling, Hugh (University College London) ; Hultman, Christina M. (Karolinska Institutet (Estocolm, Suècia)) ; Iwata, Nakao (Fujita Health University) ; Jablensky, Assen V. (UWA Centre for Clinical Research in Neuropsychiatry) ; Jonsson, Erik G. (Karolinska Institutet (Estocolm, Suècia)) ; Kendler, Kenneth S. (Virginia Commonwealth University) ; Kirov, George (Cardiff University) ; Knight, Jo (University of Toronto) ; Lencz, Todd (Zucker Hillside Hospital) ; Levinson, Douglas F. (Stanford University) ; Li, Qingqin S. (Janssen Research and Development) ; Liu, Jianjun (National University of Singapore) ; Malhotra, Anil K. (Zucker Hillside Hospital) ; McCarroll, Steven A. (Harvard Medical School) ; McQuillin, Andrew (University College London) ; Moran, Jennifer (Broad Institute of MI.T. and Harvard) ; Mortensen, Preben Bo (Lundbeck Foundation Initiative for Integrative Psychiatric Research) ; Mowry, Bryan J. (University of Queensland) ; Owen, Michael J. (Cardiff University) ; Palotie, Aaron (Broad Institute of MI.T. and Harvard) ; Pato, Carlos N. (University of Southern California) ; Petryshen, Tracey L. (Massachusetts General Hospital) ; Posthuma, Danielle (Vrije Universiteit Amsterdam) ; Riley, Brien Patrick (Virginia Commonwealth University) ; Rujescu, Dan (University of Munich) ; Sham, Pak C. (University of Hong Kong) ; Sklar, Pamela (Icahn School of Medicine at Mount Sinai) ; St Clair, David (University of Aberdeen) ; Weinberger, Daniel R. (Johns Hopkins School of Medicine) ; Wendland, Jens (Pfizer Worldwide Research and Development) ; Werge, Thomas (University of Copenhagen) ; Daly, Mark J. (Massachusetts General Hospital) ; Sullivan, Patrick F. (University of North Carolina) ; O'Donovan, Michael C. (Cardiff University) ; Universitat Autònoma de Barcelona
We have previously shown higher-than-expected rates of schizophrenia in relatives of patients with amyotrophic lateral sclerosis (ALS), suggesting an aetiological relationship between the diseases. Here, we investigate the genetic relationship between ALS and schizophrenia using genome-wide association study data from over 100,000 unique individuals. [...]
2017 - 10.1038/ncomms14774
Nature communications, Vol. 8 (21 2017) , p. 14774  
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33 p, 892.7 KB Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors / Mullins, Niamh ; Kang, JooEun ; Campos, Adrian I. ; Coleman, Jonathan R.I. ; Edwards, Alexis C. ; Galfalvy, Hanga ; Levey, Daniel F. ; Lori, Adriana ; Shabalin, Andrey ; Starnawska, Anna ; Su, Mei-Hsin ; Watson, Hunna J. ; Adams, Mark ; Awasthi, Swapnil ; Gandal, Michael ; Hafferty, Jonathan D. ; Hishimoto, Akitoyo ; Kim, Minsoo ; Okazaki, Satoshi ; Otsuka, Ikuo ; Ripke, Stephan ; Ware, Erin B. ; Bergen, Andrew W. ; Berrettini, Wade H. ; Bohus, Martin ; Brandt, Harry ; Chang, Xiao ; Chen, Wei J. ; Chen, Hsi-Chung ; Crawford, Steven ; Crow, Scott ; DiBlasi, Emily ; Duriez, Philibert ; Fernández-Aranda, Fernando (Hospital Universitari de Bellvitge) ; Fichter, Manfred M. ; Gallinger, Steven ; Glatt, Stephen J. ; Gorwood, Philip ; Guo, Yiran ; Hakonarson, Hakon ; Halmi, Katherine A. ; Hwu, Hai-Gwo ; Jain, Sonia ; Jamain, Stéphane ; Jiménez-Murcia, Susana (Hospital Universitari de Bellvitge) ; Johnson, Craig ; Kaplan, Allan S. ; Kaye, Walter H. ; Keel, Pamela K. ; Kennedy, James L. ; Klump, Kelly L. ; Li, Dong (Children's Hospital of Philadelphia (Pennsilvània)) ; Liao, Shih-Cheng ; Lieb, Klaus ; Lilenfeld, Lisa ; Liu, Chih-Min ; Magistretti, Pierre J. ; Marshall, Christian R. ; Mitchell, James E. ; Monson, Eric T. ; Myers, Richard M. ; Pinto, Dalila ; Powers, Abigail ; Ramoz, Nicolas ; Roepke, Stefan ; Rozanov, Vsevolod ; Scherer, Stephen W. ; Schmahl, Christian ; Sokolowski, Marcus ; Strober, Michael ; Thornton, Laura M. ; Treasure, Janet ; Tsuang, Ming T. ; Witt, Stephanie H. ; Woodside, D. Blake ; Yilmaz, Zeynep ; Zillich, Lea ; Adolfsson, Rolf ; Agartz, Ingrid ; Air, Tracy M. ; Alda, Martin ; Alfredsson, Lars ; Andreassen, Ole A. ; Anjorin, Adebayo ; Appadurai, Vivek ; Soler Artigas, María (Hospital Universitari Vall d'Hebron) ; Van der Auwera, Sandra ; Azevedo, M. Helena ; Bass, Nicholas ; Bau, Claiton Henrique Dotto ; Baune, Bernhard T. ; Bellivier, Frank ; Berger, Klaus ; Biernacka, Joanna M. ; Bigdeli, Tim B. ; Binder, Elisabeth B. ; Boehnke, Michael ; Boks, Marco P. ; Bosch, Rosa (Hospital Universitari Vall d'Hebron) ; Braff, David L. ; Bryant, Richard ; Budde, Monika ; Byrne, Enda M. ; Cahn, Wiepke ; Casas Brugué, Miquel (Hospital Universitari Vall d'Hebron) ; Castelao, Enrique ; Cervilla, Jorge A. ; Chaumette, Boris ; Cichon, Sven ; Corvin, Aiden ; Craddock, Nicholas ; Craig, David ; Degenhardt, Franziska ; Djurovic, Srdjan ; Edenberg, Howard J. ; Fanous, Ayman H. ; Foo, Jerome C. ; Forstner, Andreas J. ; Frye, Mark ; Fullerton, Janice M. ; Gatt, Justine M. ; Gejman, Pablo V. ; Giegling, Ina ; Grabe, Hans J. ; Green, Melissa J. ; Grevet, Eugenio H. ; Grigoroiu-Serbanescu, Maria ; Gutierrez, Blanca ; Guzman-Parra, Jose ; Hamilton, Steven P. ; Hamshere, Marian L. ; Hartmann, Annette ; Hauser, Joanna ; Heilmann-Heimbach, Stefanie ; Hoffmann, Per ; Ising, Marcus ; Jones, Ian ; Jones, Lisa A. ; Jonsson, Lina ; Kahn, René S. ; Kelsoe, John R. ; Kendler, Kenneth S. ; Kloiber, Stefan ; Koenen, Karestan C. ; Kogevinas, M ; Konte, Bettina ; Krebs, Marie-Odile ; Landén, Mikael ; Lawrence, Jacob ; Leboyer, Marion ; Lee, Phil H. ; Levinson, Douglas F. ; Liao, Calwing ; Lissowska, Jolanta ; Lucae, Susanne ; Mayoral-Cleries, Fermín ; McElroy, Susan L. ; McGrath, Patrick ; McGuffin, Peter ; McQuillin, Andrew ; Medland, Sarah E. ; Mehta, Divya ; Melle, Ingrid ; Milaneschi, Yuri ; Mitchell, Philip B. ; Molina, Esther ; Morken, Gunnar ; Bo Mortensen, Preben ; Müller-Myhsok, Bertram ; Nievergelt, Caroline ; Nimgaonkar, Vishwajit ; Nöthen, Markus M. ; O'Donovan, Michael C. (Cardiff University) ; Ophoff, Roel A. ; Owen, Michael J. ; Pato, Carlos ; Pato, Michele T. ; Penninx, Brenda WJH ; Pimm, Jonathan ; Pistis, Giorgio ; Potash, James B. ; Power, Robert A. ; Preisig, Martin ; Quested, Digby ; Ramos-Quiroga, Josep Antoni (Hospital Universitari Vall d'Hebron) ; Reif, Andreas ; Ribasés Haro, Marta (Hospital Universitari Vall d'Hebron) ; Richarte, Vanesa (Hospital Universitari Vall d'Hebron) ; Rietschel, Marcella ; Rivera, Margarita ; Roberts, Andrea ; Roberts, Gloria ; Rouleau, Guy A. ; Rovaris, Diego L. ; Rujescu, Dan ; Sánchez-Mora, Cristina (Hospital Universitari Vall d'Hebron) ; Sanders, Alan R. ; Schofield, Peter R. ; Schulze, Thomas G. ; Scott, Laura J. ; Serretti, Alessandro ; Shi, Jianxin ; Shyn, Stanley I. ; Sirignano, Lea ; Sklar, Pamela ; Smeland, Olav B. ; Smoller, Jordan W. ; Sonuga-Barke, Edmund J.S. ; Spalletta, Gianfranco ; Strauss, John S. ; Świątkowska, Beata ; Trzaskowski, Maciej ; Turecki, Gustavo ; Vilar-Ribó, L (Hospital Universitari Vall d'Hebron) ; Vincent, John B. ; Völzke, Henry ; Walters, James T.R. ; Weickert, Cynthia Shannon ; Weickert, Thomas W. ; Weissman, Myrna M. ; Williams, Leanne M. ; Wray, Naomi R. ; Zai, Clement C. ; Ashley-Koch, Allison E. ; Beckham, Jean C. ; Hauser, Elizabeth R. ; Hauser, Michael A. ; Kimbrel, Nathan A. ; Lindquist, Jennifer H. ; McMahon, Benjamin ; Oslin, David W. ; Qin, Xuejun ; Agerbo, Esben ; Børglum, Anders D. ; Breen, Gerome ; Erlangsen, Annette ; Esko, Tõnu ; Gelernter, Joel ; Hougaard, David M. ; Kessler, Ronald C. ; Kranzler, Henry R. ; Li, Qingqin S. ; Martin, Nicholas G. ; McIntosh, Andrew M. ; Mors, Ole ; Nordentoft, Merete ; Olsen, Catherine M. ; Porteous, David ; Ursano, Robert J. ; Wasserman, Danuta ; Werge, Thomas ; Whiteman, David C. ; Bulik, Cynthia M. ; Coon, Hilary ; Demontis, Ditte ; Docherty, Anna R. ; Kuo, Po-Hsiu ; Lewis, Cathryn M. ; Mann, J. John ; Rentería, Miguel E. ; Smith, Daniel J. ; Stahl, Eli A. ; Stein, Murray B. ; Streit, Fabian ; Willour, Virginia ; Ruderfer, Douglas M. ; Universitat Autònoma de Barcelona
Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. [...]
2021 - 10.1016/j.biopsych.2021.05.029
Biological psychiatry, Vol. 91 (september 2021) , p. 313-327  
3.
21 p, 2.5 MB Ancient Haplotypes at the 15q24.2 Microdeletion Region Are Linked to Brain Expression of MAN2C1 and Children's Intelligence / Cáceres, Alejandro (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ; Esko, Tõnu (University of Tartu. Estonian Genome Center) ; Pappa, Irene (Erasmus Medical Center) ; Gutiérrez, Armand (Institut Hospital del Mar d'Investigacions Mèdiques) ; Lopez-Espinosa, Maria-Jose (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ; Llop, Sabrina (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ; Bustamante, Mariona (Centre de Regulació Genòmica) ; Tiemeier, Henning (Erasmus Medical Center. Department of Psychiatry) ; Metspalu, Andres (University of Tartu. Institute of Molecular and Cell Biology) ; Joshi, Peter K. (University of Edinburgh. Centre for Global Health Research) ; Wilsonx, James F. (University of Edinburgh. Institute of Genetics and Molecular Medicine) ; Reina-Castillón, Judith (Institut Hospital del Mar d'Investigacions Mèdiques) ; Shin, Jean (University of Toronto. Hospital for Sick Children) ; Pausova, Zdenka (University of Toronto. Hospital for Sick Children) ; Paus, Tomáš (University of Toronto. Rotman Research Institute) ; Sunyer, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ; Pérez-Jurado, Luis Alberto (Institut Hospital del Mar d'Investigacions Mèdiques) ; González, Juan Ramón (Universitat Autònoma de Barcelona. Departament de Matemàtiques)
The chromosome bands 15q24. 1-15q24. 3 contain a complex region with numerous segmental duplications that predispose to regional microduplications and microdeletions, both of which have been linked to intellectual disability, speech delay and autistic features. [...]
2016 - 10.1371/journal.pone.0157739
PloS one, Vol. 11, Issue 6 (June 2016) , art. e0157739  
4.
17 p, 5.3 MB Associations of autozygosity with a broad range of human phenotypes / Clark, David W. (University of Edinburgh) ; Okada, Yukinori (Osaka University, Suita) ; Moore, Kristjan H. S. (deCODE genetics/Amgen Inc., Reykjavik, Iceland) ; Mason, Dan (Bradford Teaching Hospitals NHS Trust, Bradford, UK) ; Pirastu, Nicola (University of Edinburgh, Usher Institute) ; Gandin, Ilaria (University of Trieste) ; Mattsson, Hannele (University of Helsinki) ; Barnes, Catriona L. K. (University of Edinburgh) ; Lin, Kuang (University of Oxford) ; Zhao, Jing Hua (University of Cambridge) ; Deelen, Patrick (University Medical Centre Groningen, University of Groningen) ; Rohde, Rebecca (University of North Carolina. Department of Epidemiology) ; Schurmann, Claudia (Ichan School of Medicine at Mount Sinai) ; Guo, Xiuqing (The Institute for Translational Genomics and Population Sciences, Torrance, California, USA) ; Giulianini, Franco (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ; Zhang, Weihua (Ealing Hospital, Middlesex) ; Medina-Gomez, Carolina (Erasmus University Medical Center) ; Karlsson, Robert (Karolinska Institutet (Estocolm, Suècia)) ; Bao, Yanchun (University of Essex) ; Bartz, Traci M. (University of Washington) ; Baumbach, Clemens (Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg) ; Biino, Ginevra (National Research Council of Italy) ; Bixley, Matthew J. (University of Otago) ; Brumat, Marco (University of Trieste) ; Chai, Jin-Fang (National University of Singapore, Singapore) ; Corre, Tanguy (Swiss Institute of Bioinformatics) ; Cousminer, Diana L. (University of Pennsylvania) ; Dekker, Annelot M. (Utrecht University) ; Eccles, David (Instituto de Investigación Biomédica de Málaga) ; van Eijk, Kristel R. (Utrecht University) ; Fuchsberger, Christian (Affiliated Institute of the University of Lübeck, Bolzano, Italy) ; Gao, He (Imperial College London) ; Germain, Marine (ICAN Institute for Cardiometabolism and Nutrition) ; Gordon, Scott D. (QIMR Berghofer Institute of Medical Research) ; de Haan, Hugoline G. (Leiden University Medical Center) ; Harris, Sarah E. (University of Edinburgh) ; Hofer, Edith (Medical University of Graz) ; Huerta-Chagoya, Alicia (CONACyT, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico, 03940 México) ; Igartua, Catherine (University of Chicago. Department of Human Genetics) ; Jansen, Iris E. (VU University Medical Center, Amsterdam Neuroscience. Alzheimer Center Department of Neurology) ; Jia, Yucheng (Division of Genomic Outcomes, Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, 90502 USA) ; Kacprowski, Tim (TUM School of Life Sciences Weihenstephan, Technical University of Munich. Chair of Experimental Bioinformatics) ; Karlsson, Torgny (Uppsala University. Department of Immunology, Genetics and Pathology, Science for Life Laboratory) ; Kleber, Marcus E. (Heidelberg University. Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim) ; Li, Shengchao Alfred (Leidos Biomedical Research, Inc., Frederick National Lab for Cancer Research. Cancer Genomics Research Laboratory) ; Li-Gao, Ruifang (Leiden University Medical Center. Department of Clinical Epidemiology) ; Mahajan, Anubha (University of Oxford. Wellcome Centre for Human Genetics) ; Matsuda, Koichi (Graduate school of Frontier Sciences, The University of Tokyo. Department of Computational Biology and Medical Sciences) ; Meidtner, Karina (German Center for Diabetes Research (DZD)) ; Meng, Weihua (Medical Research Institute, Ninewells Hospital and School of Medicine, University of Dundee) ; Montasser, May E. (University of Maryland, School of Medicine. Program for Personalized and Genomic Medicine, Department of Medicine) ; van der Most, Peter J. (University of Groningen, University Medical Center Groningen. Department of Epidemiology) ; Munz, Matthias (Humboldt-Universität zu Berlin) ; Nutile, Teresa (Institute of Genetics and Biophysics A. Buzzati-Traverso - CNR) ; Palviainen, Teemu (Finnish Institute for Molecular Medicine, University of Helsinki) ; Prasad, Gauri (Genomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology) ; Prasad, Rashmi B. (Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Lund University, Skåne University Hospital, Malmö, 20502 Sweden) ; Priyanka, Tallapragada Divya Sri (CSIR-Centre for Cellular and Molecular Biology. Genomic Research on Complex diseases (GRC Group)) ; Rizzi, Federica (University of Milano. Department of Health Sciences) ; Salvi, Erika (IRCCS Foundation Carlo Besta Neurological Institute. Neuroalgology Unit) ; Sapkota, Bishwa R. (University of Oklahoma Health Sciences Center. Department of Pediatrics, College of Medicine) ; Shriner, Daniel (National Human Genome Research Institute, National Institutes of Health. Center for Research on Genomics and Global Health) ; Skotte, Line (Statens Serum Institut. Department of Epidemiology Research) ; Smart, Melissa C. (Institute for Social and Economic Research, University of Essex) ; Smith, Albert Vernon (University of Iceland. Faculty of Medicine, School of Health Sciences) ; van der Spek, Ashley (Erasmus University Medical Center. Department of Epidemiology) ; Spracklen, Cassandra N. (University of North Carolina. Department of Genetics) ; Strawbridge, Rona J. (Karolinska Institutet. Cardiovascular Medicine Unit, Department of Medicine Solna, Centre for Molecular Medicine) ; Tajuddin, Salman M. (National Institute on Aging, National Institutes of Health. Laboratory of Epidemiology and Population Sciences) ; Trompet, Stella (Leiden University Medical Center. Section of Gerontology and Geriatrics, Department of Internal Medicine) ; Turman, Constance (Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health) ; Verweij, Niek (University of Groningen, University Medical Center Groningen, Department of Cardiology, Ther Netherlands) ; Viberti, Clara (University of Turin, Italy. Italian Institute for Genomic Medicine (IIGM) and Dept. Medical Sciences) ; Wang, Lihua (Washington University School of Medicine. Division of Statistical Genomics, Department of Genetics) ; Warren, Helen R. (William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London. Department of Clinical Pharmacology) ; Wootton, Robyn E. (School of Psychological Science, University of Bristol) ; Yanek, Lisa R. (Johns Hopkins University School of Medicine. Department of Medicine, GeneSTAR Research Program) ; Yao, Jie (Division of Genomic Outcomes, Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, 90502 USA) ; Yousri, Noha A. (Alexandria University. Computer and Systems Engineering) ; Zhao, Wei (University of Michigan. Department of Epidemiology, School of Public Health) ; Adeyemo, Adebowale A. (National Human Genome Research Institute, National Institutes of Health. Center for Research on Genomics and Global Health) ; Afaq, Saima (Imperial College London. Department of Epidemiology and Biostatistics) ; Aguilar-Salinas, Carlos Alberto (Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud. Unidad de Investigacion de Enfermades Metabolicas) ; Akiyama, Masato (Graduate School of Medical Sciences, Kyushu University, Fukuoka. Department of Ophthalmology) ; Albert, Matthew L. (Genentech Inc. Department of Cancer Immunology) ; Allison, Matthew A. (UC San Diego School of Medicine. Division of Preventive Medicine, Department of Family Medicine and Public Health) ; Alver, Maris (University of Tartu, University of Tartu. Estonian Genome Center) ; Aung, Tin (Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Department of Ophthalmology) ; Azizi, Fereidoun (Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences. Endocrine Research Center) ; Bentley, Amy R. (National Human Genome Research Institute, National Institutes of Health. Center for Research on Genomics and Global Health) ; Boeing, Heiner (German Institute of Human Nutrition Potsdam-Rehbruecke. Department of Epidemiology) ; Boerwinkle, Eric (UTHealth School of Public Health, University of Texas. Health Science Center at Houston) ; Borja, Judith B. (USC-Office of Population Studies Foundation, Inc., Department of Nutrition and Dietetics, Talamban, University of San Carlos) ; de Borst, Gert J. (University Medical Center Utrecht) ; Bottinger, Erwin P. (Hasso Plattner Institute, Universität Potsdam. Digital Health Center) ; Broer, Linda (Erasmus University Medical Center. Department of Internal Medicine) ; Campbell, Harry (University of Edinburgh. Centre for Global Health Research, Usher Institute) ; Chanock, Stephen (National Cancer Institute, National Institutes of Health. Division of Cancer Epidemiology & Genetics) ; Chee, Miao-Li (Singapore Eye Research Institute, Singapore National Eye Centre, Singapore) ; Chen, Guanjie (National Human Genome Research Institute, National Institutes of Health. Center for Research on Genomics and Global Health) ; Chen, Yii Der Ida (Division of Genomic Outcomes, Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA) ; Chen, Zhengming (University of Oxford. Nuffield Department of Population Health) ; Chiu, Yen-Feng (Institute of Population Health Sciences, National Health Research Institutes) ; Cocca, Massimiliano (Institute for Maternal and Child Health - IRCCS Burlo Garofolo) ; Collins, Francis S. (National Human Genome Research Institute, National Institutes of Health) ; Concas, Maria Pina (Institute for Maternal and Child Health - IRCCS Burlo Garofolo) ; Corley, Janie (University of Edinburgh. Department of Psychology) ; Cugliari, Giovanni (University of Turin, Italy. Italian Institute for Genomic Medicine (IIGM) and Dept. Medical Sciences) ; van Dam, Rob M. (Harvard T.H. Chan School of Public Health. Department of Nutrition) ; Damulina, Anna (Medical University of Graz. Clinical Division of Neurogeriatrics, Department of Neurology) ; Daneshpour, Maryam S. (Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences. Cellular and Molecular Endocrine Research Center) ; Day, Felix R. (University of Cambridge School of Clinical Medicine. MRC Epidemiology Unit) ; Delgado, Graciela E. (Heidelberg University. Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim) ; Dhana, Klodian (Rush University Medical Center. Department of Internal Medicine) ; Doney, Alexander S. F. (Molecular and Clinical Medicine, University of Dundee. MEMO Research) ; Dörr, Marcus (DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, 17475 Germany) ; Doumatey, Ayo P. (National Human Genome Research Institute, National Institutes of Health. Center for Research on Genomics and Global Health) ; Dzimiri, Nduna (King Faisal Specialist Hospital and Research Centre (Aràbia Saudita)) ; Ebenesersdóttir, S. Sunna (University of Iceland. Department of Anthropology) ; Elliott, Joshua (Imperial College London. Department of Epidemiology and Biostatistics) ; Elliott, Paul (Health Data Research UK - London, London, England) ; Ewert, Ralf (University Medicine Greifswald. Department of Internal Medicine B) ; Felix, Janine F. (Erasmus University Medical Center. Department of Pediatrics) ; Fischer, Krista (University of Tartu, University of Tartu. Estonian Genome Center) ; Freedman, Barry I (Wake Forest School of Medicine. Section on Nephrology, Department of Internal Medicine) ; Girotto, Giorgia (Institute for Maternal and Child Health - IRCCS Burlo Garofolo. Medical Genetics) ; Goel, Anuj (University of Oxford. Division of Cardiovascular Medicine, Radcliffe Department of Medicine) ; Gögele, Martin (Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, 39100 Italy) ; Goodarzi, Mark O. (Cedars-Sinai Medical Center. Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine) ; Graff, Mariaelisa (University of North Carolina. Department of Epidemiology, Gillings School of Global Public Health) ; Granot-Hershkovitz, Einat (Hebrew University-Hadassah Medical Center. Braun School of Public Health) ; Grodstein, Francine (Harvard T.H. Chan School of Public Health. Department of Epidemiology) ; Guarrera, Simonetta (University of Turin, Italy. Italian Institute for Genomic Medicine (IIGM) and Dept. Medical Sciences) ; Gudbjartsson, Daniel F. (School of Engineering and Natural Sciences, University of Iceland) ; Guity, Kamran (Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences. Cellular and Molecular Endocrine Research Center) ; Gunnarsson, Bjarni (deCODE genetics/Amgen Inc., Reykjavik 101, Iceland) ; Guo, Yu (Chinese Academy of Medical Sciences) ; Hagenaars, Saskia P. (Institute of Psychiatry, Psychology & Neuroscience, King's College London. Social, Genetic and Developmental Psychiatry Centre) ; Haiman, Christopher A. (Keck School of Medicine, University of Southern California. Department of Preventive Medicine) ; Halevy, Avner (Hebrew University-Hadassah Medical Center. Braun School of Public Health) ; Harris, Tamara B. (National Institute on Aging, National Institutes of Health. Laboratory of Epidemiology and Population Sciences) ; Hedayati, Mehdi (Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences. Cellular and Molecular Endocrine Research Center) ; van Heel, David A. (Blizard Institute, Queen Mary University of London) ; Hirata, Makoto (Institute of Medical Science, The University of Tokyo. Laboratory of Genome Technology) ; Höfer, Imo (University Medical Center Utrecht) ; Hsiung, Chao Agnes (Institute of Population Health Sciences, National Health Research Institutes) ; Huang, Jinyan (Shanghai Institute of Hematology, State Key Laboratory Of Medical Genomics, Rui-jin Hospital, Shanghai Jiao Tong University School of Medicine) ; Hung, Yi-Jen (National Defense Medical Center. School of Medicine) ; Ikram, M. Arfan (Erasmus University Medical Center. Department of Epidemiology) ; Jagadeesan, Anuradha (University of Iceland. Department of Anthropology) ; Jousilahti, Pekka (National Institute for Health and Welfare. Unit of Public Health Promotion) ; Kamatani, Yoichiro (Kyoto University Graduate School of Medicine. Center for Genomic Medicine) ; Kanai, Masahiro (Harvard Medical School. Department of Biomedical Informatics) ; Kerrison, Nicola D. (University of Cambridge School of Clinical Medicine. MRC Epidemiology Unit) ; Kessler, Thorsten (Klinik für Herz- und Kreislauferkrankungen, Technische Universität München. Deutsches Herzzentrum München) ; Khaw, Kay-Tee (University of Cambridge. Department of Public Health and Primary Care) ; Khor, Chiea Chuen (Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore. Human Genetics) ; de Kleijn, Dominique P. V (University Medical Center Utrecht) ; Koh, Woon-Puay (Duke-NUS Medical School. Health Services and Systems Research) ; Kolcic, Ivana (University of Split. Centre for Global Health, Faculty of Medicine) ; Kraft, Peter (Harvard T.H. Chan School of Public Health. Department of Nutrition) ; Krämer, Bernhard K. (Heidelberg University. Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim) ; Kutalik, Zoltán (Swiss Institute of Bioinformatics) ; Kuusisto, Johanna (Kuopio University Hospital ( Finlàndia)) ; Langenberg, Claudia (University of Cambridge School of Clinical Medicine. MRC Epidemiology Unit) ; Launer, Lenore J. (National Institute on Aging, National Institutes of Health. Laboratory of Epidemiology and Population Sciences) ; Lawlor, Deborah A. (Population Health Science, Bristol Medical School, Bristol, BS8 2BY UK) ; Lee, I-Te (Chung Shan Medical University, Taichung, Taiwan. School of Medicine) ; Lee, Wen-Jane (Taichung Veterans General Hospital. Department of Medical Research) ; Lerch, Markus M. (University Medicine Greifswald. Department of Internal Medicine A) ; Li, Liming (Peking University Health Science Centre, Peking University. Department of Epidemiology and Biostatistics) ; Liu, Jianjun (Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore. Human Genetics) ; Loh, Marie (Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Department of Biochemistry) ; London, Stephanie J. (National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services) ; Loomis, Stephanie (Johns Hopkins Bloomberg School of Public Health. Department of Epidemiology) ; Lu, Yingchang (Icahn School of Medicine at Mount Sinai (Nova York, Estats Units d'Amèrica)) ; Luan, Jian'an (University of Cambridge School of Clinical Medicine. MRC Epidemiology Unit) ; Mägi, Reedik (University of Tartu, University of Tartu. Estonian Genome Center) ; Manichaikul, Ani W. (University of Virginia School of Medicine. Center for Public Health Genomics) ; Manunta, Paolo (Genomics of Renal Diseases and Hypertension Unit, IRCCS San Raffaele Scientific Institute, Università Vita Salute San Raffaele, Milano, 20132 Italy) ; Másson, Gísli (deCODE genetics/Amgen Inc., Reykjavik 101, Iceland) ; Matoba, Nana (Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045 Japan) ; Mei, Xue W. (University of Oxford. Nuffield Department of Population Health) ; Meisinger, Christa (Helmholtz Zentrum München, Independent Research Group Clinical Epidemiology, Neuherberg, 85764 Germany) ; Meitinger, Thomas (DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance) ; Mezzavilla, Massimo (Institute for Maternal and Child Health - IRCCS Burlo Garofolo. Medical Genetics) ; Milani, Lili (Institute of Genomics, University of Tartu. Estonian Genome Center) ; Millwood, Iona Y (University of Oxford. Nuffield Department of Population Health) ; Momozawa, Yukihide (Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045 Japan) ; Moore, Amy (National Cancer Institute, National Institutes of Health. Division of Cancer Epidemiology & Genetics) ; Morange, Pierre-Emmanuel (Aix-Marseille University. INSERM UMR_S 1263, Center for CardioVascular and Nutrition research (C2VN)) ; Moreno-Macías, Hortensia (Universidad Autónoma Metropolitana. Departamento de Economía) ; Mori, Trevor A. (The University of Western Australia. Medical School) ; Morrison, Alanna C. (The University of Texas Health Science Center at Houston, School of Public Health, Department of Epidemiology, Human Genetics and Environmental Sciences) ; Muka, Taulant (Institute of Social and Preventive Medicine (ISPM), University of Bern) ; Murakami, Yoshinori (Institute of Medical Science, The University of Tokyo. Division of Molecular Pathology) ; Murray, Alison D. (The Institute of Medical Sciences, Aberdeen Biomedical Imaging Centre, University of Aberdeen) ; de Mutsert, Renée (Leiden University Medical Center. Department of Clinical Epidemiology) ; Mychaleckyj, Josyf C. (University of Virginia School of Medicine. Center for Public Health Genomics) ; Nalls, Mike A. (Data Tecnica International LLC, Glen Echo, MD 20812 USA) ; Nauck, Matthias (Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald) ; Neville, Matt J. (Oxford University Hospitals Trust. Oxford NIHR Biomedical Research Centre) ; Nolte, Ilja M. (University of Groningen, University Medical Center Groningen. Department of Epidemiology) ; Ong, Ken K. (University of Cambridge School of Clinical Medicine. Department of Paediatrics) ; Orozco, Lorena (Instituto Nacional de Medicina Genómica) ; Padmanabhan, Sandosh (Institute of Cardiovascular and Medical Sciences, University of Glasgow) ; Pálsson, Gunnar (deCODE genetics/Amgen Inc., Reykjavik, Iceland) ; Pankow, James S. (School of Public Health, University of Minnesota. Division of Epidemiology & Community Health) ; Pattaro, Cristian (Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, 39100 Italy) ; Pattie, Alison (University of Edinburgh. Department of Psychology) ; Polasek, Ozren (Gen-info Ltd, Zagreb, Croatia, Zagreb, Select a Province Croatia) ; Poulter, Neil (Imperial College London, London. Imperial Clinical Trials Unit) ; Pramstaller, Peter P. (Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, 39100 Italy) ; Quintana-Murci, Lluis (Institut Pasteur. Center of Bioinformatics, Biostatistics and Integrative Biology) ; Räikkönen, Katri (University of Helsinki, University of Helsinki. Department of Psychology and Logopedics, Faculty of Medicine) ; Ralhan, Sarju (Hero Heart Institute and Dyanand Medical College and Hospital) ; Rao, Dabeeru C. (Washington University School of Medicine. Division of Biostatistics) ; van Rheenen, Wouter (University Medical Centre Utrecht, Utrecht University. Department of Neurology, Brain Centre Rudolf Magnus) ; Rich, Stephen S. (University of Virginia School of Medicine. Center for Public Health Genomics) ; Ridker, Paul M. (Harvard Medical School) ; Rietveld, Cornelius A. (Erasmus University Rotterdam Institute for Behavior and Biology, Erasmus University Rotterdam) ; Robino, Antonietta (Institute for Maternal and Child Health - IRCCS Burlo Garofolo) ; van Rooij, Frank J. A. (Erasmus University Medical Center. Department of Epidemiology) ; Ruggiero, Daniela (IRCCS Neuromed) ; Saba, Yasaman (Medical University of Graz. Gottfried Schatz Research Center (for Cell Signaling, Metabolism and Aging), Division of Molecular Biology and Biochemistry) ; Sabanayagam, Charumathi (Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Department of Ophthalmology) ; Sabater-Lleal, Maria (Institut d'Investigació Biomèdica Sant Pau) ; Sala, Cinzia Felicita (San Raffaele Research Institute, Milano, Italy) ; Salomaa, Veikko (National Institute for Health and Welfare. Department of Public Health Solutions) ; Sandow, Kevin (Division of Genomic Outcomes, Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA) ; Schmidt, Helena (Medical University of Graz. Gottfried Schatz Research Center (for Cell Signaling, Metabolism and Aging), Division of Molecular Biology and Biochemistry) ; Scott, Laura J. (University of Michigan. Department of Biostatistics, and Center for Statistical Genetics) ; Scott, William R. (Imperial College London. Department of Epidemiology and Biostatistics) ; Sedaghati-Khayat, Bahareh (Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences. Cellular and Molecular Endocrine Research Center) ; Sennblad, Bengt (National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Uppsala University, Uppsala. Dept of Cell and Molecular Biology) ; van Setten, Jessica (University Medical Center Utrecht) ; Sever, Peter J. (International Centre for Circulatory Health, Imperial College London) ; Sheu, Wayne H-H (Institute of Medical Technology, National Chung-Hsing University) ; Shi, Yuan (Singapore Eye Research Institute, Singapore National Eye Centre, Singapore) ; Shrestha, Smeeta (School of Basic and Applied Sciences, Dayananda Sagar University, Bangalore, Karnataka 560078 India) ; Shukla, Sharvari Rahul (Symbiosis Statistical Institute, Symbiosis International University) ; Sigurdsson, Jon K. (deCODE genetics/Amgen Inc., Reykjavik 101, Iceland) ; Sikka, Timo Tonis (University of Tartu, University of Tartu. Estonian Genome Center) ; Singh, Jai Rup (Panjab University) ; Smith, Blair H. (Ninewells Hospital and Medical School, University of Dundee. Division of Population Health Sciences) ; Stančáková, Alena (Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland) ; Stanton, Alice (RCSI Molecular & Cellular Therapeutics (MCT), Royal College of Surgeons in Ireland, RCSI Education & Research Centre, Beaumont Hospital, Dublin 9, Ireland) ; Starr, John M. (University of Edinburgh. Alzheimer Scotland Dementia Research Centre) ; Stefansdottir, Lilja (deCODE genetics/Amgen Inc., Reykjavik 101, Iceland) ; Straker, Leon (School of Physiotherapy and Exercise Science, Faculty of Health Sciences, Curtin University) ; Sulem, Patrick (deCODE genetics/Amgen Inc., Reykjavik 101, Iceland) ; Sveinbjornsson, Gardar (deCODE genetics/Amgen Inc., Reykjavik 101, Iceland) ; Swertz, Morris A. (Department of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands, Groningen, Groningen, 9700 RB The Netherlands) ; Taylor, Adele M. (University of Edinburgh. Department of Psychology) ; Taylor, Kent D. (Division of Genomic Outcomes, Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA) ; Terzikhan, Natalie (Ghent University Hospital. (Bèlgica)) ; Tham, Yih-Chung (Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore) ; Thorleifsson, Gudmar (deCODE genetics/Amgen Inc., Reykjavik 101, Iceland) ; Thorsteinsdottir, Unnur (University of Iceland. Faculty of Medicine, School of Health Sciences) ; Tillander, Annika (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics) ; Tracy, Russell P. (University of Vermont. Department of Pathology) ; Tusié-Luna, Teresa (Unidad De Biología Molecular y Medicina Genómica, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán) ; Tzoulaki, Ioanna (University of Ioannina Medical School. Department of Hygiene and Epidemiology) ; Vaccargiu, Simona (Institute of Genetic and Biomedical Research - Support Unity, National Research Council of Italy) ; Vangipurapu, Jagadish (Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland) ; Veldink, Jan (University Medical Centre Utrecht, Utrecht University. Department of Neurology, Brain Centre Rudolf Magnus) ; Vitart, Veronique (Institute of Genetics and Molecular Medicine, University of Edinburgh. MRC Human Genetics Unit) ; Völker, Uwe (DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, 17475 Germany) ; Vuoksimaa, Eero (Institute for Molecular Medicine Finland (FIMM), University of Helsinki) ; Wakil, Salma M. (King Faisal Specialist Hospital and Research Centre (Aràbia Saudita)) ; Waldenberger, Melanie (Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764 Germany) ; Wander, Gurpreet S. (Hero DMC Heart Institute, Dayanand Medical College & Hospital. Department of Cardiology) ; Wang, Ya Xing (Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Lab) ; Wareham, Nicholas J. (University of Cambridge School of Clinical Medicine. MRC Epidemiology Unit) ; Wild, Sarah (Usher Institute of Population Health and Informatics, University of Edinburgh. Centre for Population Health Sciences) ; Yajnik, Chittaranjan S. (Diabetes Unit, K.E.M. Hospital Research Centre) ; Yuan, Jian-Min (Graduate School of Public Health, University of Pittsburgh. Department of Epidemiology) ; Zeng, Lingyao (Klinik für Herz- und Kreislauferkrankungen, Technische Universität München. Deutsches Herzzentrum München) ; Zhang, Liang (Singapore Eye Research Institute, Singapore National Eye Centre, Singapore) ; Zhou, Jie (National Human Genome Research Institute, National Institutes of Health. Center for Research on Genomics and Global Health) ; Amin, Najaf (Erasmus University Medical Center. Department of Epidemiology) ; Asselbergs, Folkert W. (Farr Institute of Health Informatics Research and Institute of Health Informatics, University College London) ; Bakker, Stephan J. L. (Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, 9713GZ The Netherlands) ; Becker, Diane M. (Johns Hopkins University School of Medicine. Department of Medicine, GeneSTAR Research Program) ; Lehne, Benjamin (Imperial College London. Department of Epidemiology and Biostatistics) ; Bennett, David A. (Rush University Medical Center. Department of Neurological Sciences) ; van den Berg, Leonard H. (University Medical Centre Utrecht, Utrecht University. Department of Neurology, Brain Centre Rudolf Magnus) ; Berndt, Sonja (National Cancer Institute, National Institutes of Health. Division of Cancer Epidemiology & Genetics) ; Bharadwaj, Dwaipayan (School of Biotechnology, Jawaharlal Nehru University. Systems Genomics Laboratory) ; Bielak, Lawrence F. (University of Michigan. Department of Epidemiology, School of Public Health) ; Bochud, Murielle (University of Lausanne. Center for Primary Care and Public Health (Unisanté)) ; Boehnke, Michael (University of Michigan. Department of Biostatistics, and Center for Statistical Genetics) ; Bouchard, Claude (Pennington Biomedical Research Center) ; Bradfield, Jonathan Paul (Quantinuum Research LLC, San Diego, CA 92101 USA) ; Brody, Jennifer A. (University of Washington. Cardiovascular Health Research Unit, Department of Medicine) ; Campbell, Archie (Institute of Genetics & Molecular Medicine, University of Edinburgh. Centre for Genomic & Experimental Medicine) ; Carmi, Shai (Hebrew University-Hadassah Medical Center. Braun School of Public Health) ; Caulfield, Mark (William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London. Department of Clinical Pharmacology) ; Cesarini, David (Research Institute for Industrial Economics (IFN)) ; Chambers, John C. (Imperial College Healthcare NHS Trust, London) ; Chandak, Giriraj Ratan (CSIR-Centre for Cellular and Molecular Biology. Genomic Research on Complex diseases (GRC Group)) ; Cheng, Ching-Yu (Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Department of Ophthalmology) ; Ciullo, Marina (IRCCS Neuromed) ; Cornelis, Marilyn (Northwestern University Feinberg School of Medicine. Department of Preventive Medicine) ; Cusi, Daniele (Bio4Dreams Scientific Unit, Bio4Dreams SRL, Bio4Dreams - business nursery for life sciences, Milano, 20121 Italy) ; Smith, George Davey (Population Health Science, Bristol Medical School, Bristol, BS8 2BY UK) ; Deary, Ian J. (University of Edinburgh. Department of Psychology) ; Dorajoo, Rajkumar (Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore. Human Genetics) ; van Duijn, Cornelia M. (Erasmus University Medical Center. Department of Epidemiology) ; Ellinghaus, David (Christian-Albrechts-University of Kiel. Institute of Clinical Molecular Biology) ; Erdmann, Jeanette (University of Lübeck. Institute for Cardiogenetics) ; Eriksson, Johan G. (Vasa Central Hospital) ; Evangelou, Evangelos (University of Ioannina Medical School. Department of Hygiene and Epidemiology) ; Evans, Michele K. (National Institute on Aging, National Institutes of Health. Laboratory of Epidemiology and Population Sciences) ; Faul, Jessica D. (University of Michigan. Institute for Social Research) ; Feenstra, Bjarke (Statens Serum Institut. Department of Epidemiology Research) ; Feitosa, Mary (Washington University School of Medicine. Division of Statistical Genomics, Department of Genetics) ; Foisy, Sylvain (Montreal Heart Institute) ; Franke, Andre (Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel) ; Friedlander, Yechiel (Hebrew University-Hadassah Medical Center. Braun School of Public Health) ; Gasparini, Paolo (Institute for Maternal and Child Health - IRCCS Burlo Garofolo. Medical Genetics) ; Gieger, Christian (German Center for Diabetes Research (DZD)) ; Gonzalez, Clicerio (Centro de Estudios en Diabetes, Unidad de Investigacion en Diabetes y Riesgo Cardiovascular, Centro de Investigacion en Salud Poblacional, Instituto Nacional de Salud Publica) ; Goyette, Philippe (Montreal Heart Institute) ; Grant, Struan F. A. (Perelman School of Medicine, University of Pennsylvania. Department of Pediatrics) ; Griffiths, Lyn R. (Institute of Health and Biomedical Innovation, Queensland University of Technology. Genomics Research Centre, School of Biomedical Sciences) ; Groop, Leif (Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Lund University, Skåne University Hospital, Malmö, Sweden) ; Gudnason, Vilmundur (University of Iceland. Faculty of Medicine, School of Health Sciences) ; Gyllensten, Ulf (Uppsala University. Department of Immunology, Genetics and Pathology, Science for Life Laboratory) ; Hakonarson, Hakon (University of Pennsylvania. Perelman School of Medicine) ; Hamsten, Anders (Cardiovascular Medicine Unit, Department of Medicine Solna, Centre for Molecular Medicine, Stockholm, 171 76 Sweden) ; van der Harst, Pim (University of Groningen, University Medical Center Groningen, Department of Cardiology, Ther Netherlands) ; Heng, Chew-Kiat (Khoo Teck Puat - National University Children's Medical Institute, National University Health System) ; Hicks, Andrew A. (Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, 39100 Italy) ; Hochner, Hagit (Hebrew University-Hadassah Medical Center. Braun School of Public Health) ; Huikuri, Heikki (Research Unit of Internal Medicine, Medical Research Center Oulu, University of Oulu and Oulu University Hospital) ; Hunt, Steven C. (University of Utah School of Medicine. Division of Epidemiology, Department of Internal Medicine) ; Jaddoe, Vincent W. V (Erasmus University Medical Center. Department of Pediatrics) ; De Jager, Philip L. (Cell Circuits Program, Broad Institute) ; Johannesson, Magnus (Stockholm School of Economics. Department of Economics) ; Johansson, Åsa (Uppsala University. Department of Immunology, Genetics and Pathology, Science for Life Laboratory) ; Jonas, Jost B. (University of Heidelberg) ; Jukema, J. Wouter (Leiden University Medical Center. Department of Cardiology) ; Junttila, Juhani (Research Unit of Internal Medicine, Medical Research Center Oulu, University of Oulu and Oulu University Hospital) ; Kaprio, Jaakko (University of Helsinki. Department of Public Health) ; Kardia, Sharon L. R. (University of Michigan. Department of Epidemiology, School of Public Health) ; Karpe, Fredrik (Oxford NIHR Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital) ; Kumari, Meena (Institute for Social and Economic Research, University of Essex) ; Laakso, Markku (Kuopio University Hospital ( Finlàndia)) ; van der Laan, Sander W. (University Medical Center Utrecht) ; Lahti, Jari (University of Helsinki, University of Helsinki. Helsinki Collegium for Advanced Studies) ; Laudes, Matthias (Universitätsklinikum Schleswig-Holstein (Alemanya)) ; Lea, Rodney A. (Institute of Health and Biomedical Innovation, Queensland University of Technology. Genomics Research Centre, School of Biomedical Sciences) ; Lieb, Wolfgang (Institute of Epidemiology and PopGen Biobank, University of Kiel) ; Lumley, Thomas (University of Auckland. Department of Statistics) ; Martin, Nicholas G. (QIMR Berghofer Institute of Medical Research) ; März, Winfried (Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim, Germany) ; Matullo, Giuseppe (University of Turin, Italy. Italian Institute for Genomic Medicine (IIGM) and Dept. Medical Sciences) ; McCarthy, Mark I (Oxford NIHR Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital) ; Medland, Sarah Elizabeth (QIMR Berghofer Institute of Medical Research) ; Merriman, Tony R. (University of Otago. Department of Biochemistry) ; Metspalu, Andres (University of Tartu, University of Tartu. Estonian Genome Center) ; Meyer, Brian F. (King Faisal Specialist Hospital and Research Centre. Department of Genetics) ; Mohlke, Karen L. (University of North Carolina. Department of Genetics) ; Montgomery, Grant W. (Institute for Molecular Bioscience, The University of Queensland) ; Mook-Kanamori, Dennis (Leiden University Medical Center. Department of Public Health and Primary Care) ; Munroe, Patricia B. (Queen Mary University of London. Department of Clinical Pharmacology) ; North, Kari E. (University of North Carolina. Department of Epidemiology, Gillings School of Global Public Health) ; Nyholt, Dale R. (School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology) ; O'connell, Jeffery R. (University of Maryland, School of Medicine. Program for Personalized and Genomic Medicine, Department of Medicine) ; Ober, Carole (University of Chicago. Department of Human Genetics) ; Oldehinkel, Albertine J. (Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen. Department of Psychiatry) ; Palmas, Walter (Columbia University Medical Center. Department of Medicine) ; Palmer, Colin (Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, The School of Medicine, University of Dundee) ; Pasterkamp, Gerard G. (University Medical Center Utrecht) ; Patin, Etienne (Institut Pasteur. Center of Bioinformatics, Biostatistics and Integrative Biology) ; Pennell, Craig E. (The University of Western Australia. Division of Obstetrics and Gynaecology) ; Pérusse, Louis (Institute of Nutrition and Functional Foods, Laval University) ; Peyser, Patricia A. (University of Michigan. Department of Epidemiology, School of Public Health) ; Pirastu, Mario (Institute of Genetic and Biomedical Research - Support Unity, National Research Council of Italy) ; Polderman, Tinca J. C. (Vrije Universiteit Amsterdam. Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research) ; Porteous, David J. (Institute of Genetics & Molecular Medicine, University of Edinburgh. Centre for Genomic & Experimental Medicine) ; Posthuma, Danielle (Amsterdam Universitair Medische Centra (Amsterdam, Països Baixos)) ; Psaty, Bruce M. (Kaiser Permanente Washington Health Research Institute) ; Rioux, John D. (Université de Montréal. Department of Medicine, Faculty of Medicine) ; Rivadeneira, Fernando (The Generation R Study Group, Erasmus University Medical Center) ; Rotimi, Charles (National Human Genome Research Institute, National Institutes of Health. Center for Research on Genomics and Global Health) ; Rotter, Jerome I (Division of Genomic Outcomes, Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA) ; Rudan, Igor (University of Edinburgh. Centre for Global Health Research, Usher Institute) ; Den Ruijter, Hester M. (University Medical Center Utrecht) ; Sanghera, Dharambir K. (Oklahoma Center for Neuroscience, Oklahoma City, USA) ; Sattar, Naveed (Institute of Cardiovascular and Medical Sciences, University of Glasgow) ; Schmidt, Reinhold (Medical University of Graz. Clinical Division of Neurogeriatrics, Department of Neurology) ; Schulze, Matthias B. (Institute of Nutritional Sciences, University of Potsdam) ; Schunkert, Heribert (Deutsches Zentrum für Herz- und Kreislauferkrankungen (DZHK), Munich Heart Alliance, Munich, 80636 Germany) ; Scott, Robert A. (University of Cambridge School of Clinical Medicine. MRC Epidemiology Unit) ; Shuldiner, Alan R. (Regeneron Pharmaceuticals, Inc. Regeneron Genetics Center) ; Sim, Xueling (National University of Singapore, Singapore. Saw Swee Hock School of Public Health) ; Small, Neil (University of Bradford. Faculty of Health Studies) ; Smith, Jennifer A. (University of Michigan. Institute for Social Research) ; Sotoodehnia, Nona (University of Washington) ; Tai, E-Shyong (National University of Singapore. Duke-NUS Medical School) ; Teumer, Alexander (University Medicine Greifswald) ; Timpson, Nicholas J. (University of Bristol) ; Toniolo, Daniela (San Raffaele Research Institute, Milano, Italy) ; Tregouet, David-Alexandre (Sorbonne Universités) ; Tuomi, Tiinamaija (University of Helsinki. Research Program of Diabetes and Endocrinology) ; Vollenweider, Peter (Lausanne University Hospital) ; Wang, Carol A. (The University of Western Australia. Division of Obstetrics and Gynaecology) ; Weir, David R. (University of Michigan. Institute for Social Research) ; Whitfield, John B. (QIMR Berghofer Institute of Medical Research) ; Wijmenga, Cisca (Department of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands, Groningen, Groningen, RB The Netherlands) ; Wong, Tien-Yin (Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore) ; Wright, John (Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Trust, Bradford, UK) ; Yang, Jingyun (Rush University Medical Center. Department of Neurological Sciences) ; Yu, Lei (Rush University Medical Center. Department of Neurological Sciences) ; Zemel, Babette S. (Children's Hospital of Philadelphia (Pennsilvània)) ; Zonderman, Alan B. (National Institute on Aging, National Institutes of Health. Laboratory of Epidemiology and Population Sciences) ; Perola, Markus (National Institute for Health and Welfare. Unit of Genomics and Biomarkers) ; Magnusson, Patrik K. E. (Karolinska Institutet (Estocolm, Suècia).) ; Uitterlinden, André G. (The Generation R Study Group, Erasmus University Medical Center) ; Kooner, Jaspal S. (Imperial College London) ; Chasman, Daniel I (Harvard Medical School) ; Loos, Ruth J. F. (The Icahn School of Medicine at Mount Sinai. The Mindich Child Health and Development Institute) ; Franceschini, Nora (University of North Carolina. Department of Epidemiology, Gillings School of Global Public Health) ; Franke, Lude (Department of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands, Groningen, Groningen, The Netherlands) ; Haley, Chris S. (Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, Scotland) ; Hayward, Caroline (Institute of Genetics and Molecular Medicine, University of Edinburgh. MRC Human Genetics Unit) ; Walters, Robin G. (University of Oxford. Nuffield Department of Population Health) ; Perry, John R. B. (University of Cambridge School of Clinical Medicine. MRC Epidemiology Unit) ; Esko, Tōnu (Broad Institute, Broad Institute. Program in Medical and Population Genetics) ; Helgason, Agnar (University of Iceland. Department of Anthropology) ; Stefansson, Kari (University of Iceland. Faculty of Medicine, School of Health Sciences) ; Joshi, Peter K. (University of Edinburgh. Centre for Global Health Research, Usher Institute) ; Kubo, Michiaki (Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045 Japan) ; Wilson, James F.. (Institute of Genetics and Molecular Medicine, University of Edinburgh. MRC Human Genetics Unit) ; Universitat Autònoma de Barcelona
In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. [...]
2019 - 10.1038/s41467-019-12283-6
Nature communications, Vol. 10 (october 2019)  
5.
17 p, 1.6 MB MADloy : robust detection of mosaic loss of chromosome Y from genotype-array-intensity data / González, Juan Ramón (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ; López-Sánchez, Marcos (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Cáceres, Alejandro (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ; Puig, Pedro (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ; Esko, Tõnu (University of Tartu. Estonian Genome Centre Science Centre) ; Pérez-Jurado, Luis Alberto (University of Adelaide. South Australian Health and Medical Research Institute)
Accurate protocols and methods to robustly detect the mosaic loss of chromosome Y (mLOY) are needed given its reported role in cancer, several age-related disorders and overall male mortality. Intensity SNP-array data have been used to infer mLOY status and to determine its prominent role in male disease. [...]
2020 - 10.1186/s12859-020-03768-z
BMC bioinformatics, Vol. 21 (November 2020) , art. 533  
6.
28 p, 2.6 MB Functional impact and evolution of a novel human polymorphic inversion that disrupts a gene and creates a fusion transcript / Puig Font, Marta (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Castellano Esteve, David (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Pantano, Lorena (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Giner-Delgado, Carla (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Izquierdo Fontanills, David (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Gayà Vidal, Magdalena (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Lucas Lledó, José Ignacio (Universitat de València. Institut Cavanilles de Biodiversitat i Biologia Evolutiva) ; Esko, Tõnu (Estonian Genome Center) ; Terao, Chikashi (Kyoto University Graduate School of Medicine) ; Matsuda, Fumihiko (Center for Genomic Medicine. Kyoto University Graduate School of Medicine) ; Cáceres Aguilar, Mario (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Despite many years of study into inversions, very little is known about their functional consequences, especially in humans. A common hypothesis is that the selective value of inversions stems in part from their effects on nearby genes, although evidence of this in natural populations is almost nonexistent. [...]
2015 - 10.1371/journal.pgen.1005495
PLoS Genetics, Vol. 11, issue 10 (2015) , art. e1005495  
7.
14 p, 1.8 MB Evolutionary and functional impact of common polymorphic inversions in the human genome / Giner-Delgado, Carla (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Villatoro, Sergi (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Lerga Jaso, Jon (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Gayà Vidal, Magdalena (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Oliva Pavia, Meritxell (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Castellano Esteve, David (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Pantano, Lorena (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Bitarello, Bárbara D. (Max-Planck-Institut für Evolutionäre Anthropologie) ; Izquierdo Fontanills, David (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Noguera, Isaac (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Olalde, Iñigo (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ; Delprat Obeaga, Alejandra (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Blancher, Antoine (Centre de Physiopathologie Toulouse-Purpan) ; Lalueza-Fox, Carles (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ; Esko, Tõnu (Estonian Genome Center) ; O'Reilly, Paul F. (King's College London. Institute of Psychiatry, Psychology & Neuroscience) ; Andrés, Aida M. (Max-Planck-Institut für Evolutionäre Anthropologie) ; Ferretti, Luca (University of Oxford. Big Data Institute) ; Puig Font, Marta (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Cáceres Aguilar, Mario (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Inversions are one type of structural variants linked to phenotypic differences and adaptation in multiple organisms. However, there is still very little information about polymorphic inversions in the human genome due to the difficulty of their detection. [...]
2019 - 10.1038/s41467-019-12173-x
Nature communications, Vol. 10 (2019) , art. 4222  
8.
7 p, 299.7 KB Rare coding variants and X-linked loci associated with age at menarche / Lunetta, Kathryn L. (Boston University School of Public Health (Estats Units d'Amèrica)) ; Day, Felix R. (University of Cambridge. School of Clinical Medicine (Gran Bretanya)) ; Sulem, Patrick (deCODE Genetics (Reykjavík, Islàndia)) ; Ruth, Katherine S. (University of Exeter. Medical School (Gran Bretanya)) ; Tung, Joyce Y. (23andMe (California, Estats Units d'Amèrica)) ; Hinds, David A. (23andMe (California, Estats Units d'Amèrica)) ; Esko, Tõnu (University of Tartu. Estonian Genome Center (Estònia)) ; Elks, Cathy E. (University of Cambridge. School of Clinical Medicine (Gran Bretanya)) ; Altmaier, Elisabeth (Helmholtz Zentrum München (Alemanya)) ; He, Chunyan (Fairbanks School of Public Health (Indianapolis, Estats Units d'Amèrica)) ; Huffman, Jennifer E. (University of Edinburgh. Institute of Genetics and Molecular Medicine (Gran Bretanya)) ; Mihailov, Evelin (University of Tartu. Estonian Genome Center (Estònia)) ; Porcu, Eleonora (Institute of Genetics and Biomedical Research (Sardinia, Itàlia)) ; Robino, Antonietta (Institute for Maternal and Child Health (Trieste, Itàlia)) ; Rose, Lynda M. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ; Schick, Ursula M. (Fred Hutchinson Cancer Research Center (Seattle, Estats Units d'Amèrica)) ; Stolk, Lisette (Erasmus University Rotterdam) ; Teumer, Alexander (University Medicine Greifswald (Alemanya)) ; Thompson, Deborah J. (University of Cambridge. Centre for Cancer Genetic Epidemiology) ; Traglia, Michela (San Raffaele Scientific Institute (Milà, Itàlia)) ; Wang, Carol A. (University of Western Australia. School of Women's and Infants' Health (Crawley, Austràlia)) ; Yerges-Armstrong, Laura M. (University of Maryland School of Medicine (Estats Units d'Amèrica)) ; Antoniou, Antonis C. (University of Cambridge. Centre for Cancer Genetic Epidemiology) ; Barbieri, Caterina (San Raffaele Scientific Institute (Milà, Itàlia)) ; Coviello, Andrea D. (Boston University School of Medicine (Estats Units d'Amèrica)) ; Cucca, Francesco (Institute of Genetics and Biomedical Research (Sardinia, Itàlia)) ; Demerath, Ellen W. (University of Minnesota (Minneapolis, Estats Units d'Amèrica)) ; Dunning, Alison M. (University of Cambridge. Centre for Cancer Genetic Epidemiology) ; Gandin, Ilaria (Institute for Maternal and Child Health (Trieste, Itàlia)) ; Grove, Megan L. (University of Texas Health Science Center at Houston (Estats Units d'Amèrica)) ; Gudbjartsson, Daniel F. (deCODE Genetics (Reykjavík, Islàndia)) ; Hocking, Lynne J. (University of Aberdeen (Regne Unit)) ; Hofman, Albert (Erasmus MC (Rotterdam, Paisos Baixos)) ; Huang, Jinyan (Shanghai Jiao Tong University School of Medicine) ; Jackson, Rebecca D. (The Ohio State University (Estats Units d'Amèrica)) ; Karasik, David (Harvard Medical School (Boston, Estats Units d'Amèrica)) ; Kriebel, Jennifer (Helmholtz Zentrum München (Alemanya)) ; Lange, Ethan M. (University of North Carolina. Department of Genetics (Estats Units d'Amèrica)) ; Lange, Leslie A. (University of North Carolina. Department of Genetics (Estats Units d'Amèrica)) ; Langenberg, Claudia (University of Cambridge. School of Clinical Medicine (Gran Bretanya)) ; Li, Xin (Harvard T.H. Chan School of Public Health (Boston, Estats Units d'Amèrica)) ; Luan, Jian'an (University of Cambridge. School of Clinical Medicine (Gran Bretanya)) ; Mägi, Reedik (University of Tartu. Estonian Genome Center (Estònia)) ; Morrison, Alanna C. (University of Texas Health Science Center at Houston (Estats Units d'Amèrica)) ; Padmanabhan, Sandosh (University of Glasgow. Institute of Cardiovascular and Medical Sciences (Gran Bretanya)) ; Pirie, Ailith (University of Cambridge. Centre for Cancer Genetic Epidemiology) ; Polasek, Ozren (University of Split. School of Medicine (Croàcia)) ; Porteous, David (University of Edinburgh.Institute of Genetics and Molecular Medicine (Gran Bretanya)) ; Reiner, Alex P. (Fred Hutchinson Cancer Research Center (Seattle, Estats Units d'Amèrica)) ; Rivadeneira, Fernando (Erasmus University Rotterdam) ; Rudan, Igor (University of Edinburgh. Institute for Population Health Sciences and Informatics (Gran Bretanya)) ; Sala, Cinzia F. (San Raffaele Scientific Institute (Milà, Itàlia)) ; Schlessinger, David (National Institute on Aging (Baltimore, Estats Units d'Amèrica)) ; Scott, Robert A. (University of Cambridge. School of Clinical Medicine (Gran Bretanya)) ; Stöckl, Doris (German Research Center for Environmental Health (Germany)) ; Visser, J. (Erasmus University Rotterdam) ; Völker, Uwe (Greifswald Medical School (Alemanya)) ; Vozzi, Diego (Institute for Maternal and Child Health (Trieste, Itàlia)) ; Wilson, James G. (University of Mississippi. Department of Physiology and Biophysics (Estats Units d'Amèrica)) ; Zygmunt, Marek (Greifswald Medical School (Alemanya)) ; Boerwinkle, Eric (University of Texas Health Science Center at Houston (Estats Units d'Amèrica)) ; Buring, Julie (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ; Crisponi, Laura (Institute of Genetics and Biomedical Research (Sardinia, Itàlia)) ; Easton, Douglas F. (University of Cambridge. Centre for Cancer Genetic Epidemiology) ; Hayward, Caroline (University of Edinburgh. Institute of Genetics and Molecular Medicine (Gran Bretanya)) ; Hu, Frank B. (Harvard Medical School (Boston, Estats Units d'Amèrica)) ; Liu, Simin (Brown University. Departments of Epidemiology and Medicine (Providence, Estats Units d'Amèrica)) ; Metspalu, Andres (University of Tartu. Estonian Genome Center (Estònia)) ; Pennell, Craig E. (University of Western Australia. School of Women's and Infants' Health (Crawley, Austràlia)) ; Ridker, Paul M. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ; Strauch, Konstantin (German Research Center for Environmental Health (Germany)) ; Streeten, Elizabeth A. (University of Maryland School of Medicine (Estats Units d'Amèrica)) ; Toniolo, Daniela (San Raffaele Scientific Institute (Milà, Itàlia)) ; Uitterlinden, André G. (Erasmus University Rotterdam) ; Ulivi, Sheila (Institute for Maternal and Child Health (Trieste, Itàlia)) ; Völzke, Henry (University Medicine Greifswald (Alemanya)) ; Wareham, Nicholas J. (University of Cambridge. School of Clinical Medicine (Gran Bretanya)) ; Wellons, Melissa (Vanderbilt University Medical Center (Nashville, Estats Units d'Amèrica)) ; Franceschini, Nora (University of North Carolina (Estats Units d'Amèrica). Department of Epidemiology) ; Chasman, Daniel I. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ; Thorsteinsdottir, Unnur (deCODE Genetics (Reykjavík, Islàndia)) ; Murray, Anna (University of Exeter. Medical School (Gran Bretanya)) ; Stefánsson, Kári (deCODE Genetics (Reykjavík, Islàndia)) ; Murabito, Joanne M. (National Heart, Lung, and Blood Institute (Framingham, Estats Units d'Amèrica)) ; Ong, Ken K. (University of Cambridge. School of Clinical Medicine (Gran Bretanya)) ; Perry, John R. B. (University of Cambridge. School of Clinical Medicine (Gran Bretanya))
More than 100 loci have been identified for age at menarche by genome-wide association studies; however, collectively these explain only ∼3% of the trait variance. Here we test two overlooked sources of variation in 192,974 European ancestry women: low-frequency protein-coding variants and X-chromosome variants. [...]
2015 - 10.1038/ncomms8756
Nature communications, Vol. 4 Núm. 6 (august 2015)  

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