Results overview: Found 5 records in 0.02 seconds.
Articles, 4 records found
Research literature, 1 records found
Articles 4 records found  
1.
2 p, 188.6 KB Synthesis, in vitro profiling, and in vivo efficacy studies of a new family of multitarget antiAlzheimer compounds / Pérez-Areales, Francisco Javier (University of Barcelona) ; Garrido, María (Instituto de Química Avanzada de) ; Catalunya (IQAC-CSIC) ; Aso, Ester (University of Barcelona) ; Bartolini, Manuela (Department of Pharmacy and Biotechnology. Alma Mater Studiorum University of Bologna) ; De Simone, Angela (University of Bologna. Department for Life Quality Studies) ; Espargaró Colomé, Alba (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Ginex, Tiziana (University of Barcelona) ; Sabate, Raimon (University of Barcelona) ; Pérez, Belén (Autonomous University of Barcelona. Therapeutics and Toxicology) ; Andrisano, Vincenza (University of Bologna. Department for Life Quality Studies) ; Luque, Francisco Javier (University of Barcelona) ; Ferrer, Isidro (Universitat de Barcelona. Unitat de Neuropatologia Experimental) ; Ciruela, Francisco (University of Barcelona) ; Messeguer, Àngel (Instituto de Química Avanzada de) ; Catalunya (IQAC-CSIC) ; Muñoz Torrero, Diego (Universitat de Barcelona. Laboratori de Química Farmacèutica)
Simultaneous modulation of several targets or athological events with a key pathogenic role is a promising strategy to tackle thus far difficult-to-cure or incurable multifactorial diseases, such as Alzheimer's disease (AD). [...]
2019 - 10.3390/proceedings2019022071
Proceedings, Vol. 22 (2019) , p. 1-2  
2.
10 p, 5.7 MB Characterization of the amyloid bacterial inclusion bodies of the HET-s fungal prion / Sabaté, Raimon (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecularar) ; Espargaró Colomé, Alba (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Saupe, Sven J. (Université Victor Segalen. Laboratoire de Génétique Moléculaire des Champignons (Burdeus, França))
The formation of amyloid aggregates is related to the onset of a number of human diseases. Recent studies provide compelling evidence for the existence of related fibrillar structures in bacterial inclusion bodies (IBs). [...]
2009 - 10.1186/1475-2859-8-56
Microbial cell factories, Vol. 8, N. 56 (October 2009) , p. 1-10  
3.
11 p, 1.6 MB Using bacterial inclusion bodies to screen for amyloid aggregation inhibitors / Villar Piqué, Anna (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Espargaró Colomé, Alba (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Sabaté, Raimon (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Sánchez de Groot, Natalia (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Background: The amyloid-β peptide (Aβ42) is the main component of the inter-neuronal amyloid plaques characteristic of Alzheimer's disease (AD). The mechanism by which Aβ42 and other amyloid peptides assemble into insoluble neurotoxic deposits is still not completely understood and multiple factors have been reported to trigger their formation. [...]
2012 - 10.1186/1475-2859-11-55
Microbial cell factories, Vol. 11, N. 55 (May 2012) , p. 1-11  
4.
12 p, 2.5 MB Yeast prions form infectious amyloid inclusion bodies in bacteria / Espargaró Colomé, Alba (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Ventura, Salvador (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Villar Piqué, Anna (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Sabaté, Raimon (Universitat de Barcelona. Departament de Fisicoquímica)
Background: Prions were first identified as infectious proteins associated with fatal brain diseases in mammals. However, fungal prions behave as epigenetic regulators that can alter a range of cellular processes. [...]
2012 - 10.1186/1475-2859-11-89
Microbial cell factories, Vol. 11, N. 89 (June 2012) , p. 1-12
2 documents

Research literature 1 records found  
1.
182 p, 7.8 MB Modelos proteicos para el estudio de la agregación amiloide in vitro e in vivo / Espargaró Colomé, Alba ; Ventura Pedret, Salvador, dir. ; Sabaté Lagunas, Raimon, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular
Durante los últimos años la agregación proteica se ha convertido en un tema de elevada importancia en biología, biotecnología y medicina. Un número creciente de evidencias demuestran fehacientemente que el mal plegamiento de proteínas y su agregación, muchas veces en forma de fibras amiloides, conlleva la formación de depósitos celulares insolubles que son los responsables finales de un creciente número de enfermedades humanas. [...]
In recent years, protein aggregation has become a topic of great importance in biology, biotechnology and medicine areas. A growing body of evidences show conclusively that the protein misfolding and aggregation, often in the form of amyloid fibrils, leading to the formation of insoluble cellular deposits that are ultimately responsible for an increasing number of human diseases. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2013  

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