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1.
18 p, 1.0 MB Assessing Associations between the AURKA-HMMR-TPX2-TUBG1 Functional Module and Breast Cancer Risk in BRCA1/2 Mutation Carriers / Blanco, Ignacio (Institut d'Investigació Biomèdica de Bellvitge) ; Kuchenbaecker, Karoline (University of Cambridge) ; Cuadras, Daniel (Institut d'Investigació Biomèdica de Bellvitge) ; Wang, Xianshu (Mayo Clinic, Rochester, United States of America) ; Barrowdale, Daniel (University of Cambridge) ; de Garibay, Gorka Ruiz (Institut d'Investigació Biomèdica de Bellvitge) ; Librado, Pablo (Universitat de Barcelona) ; Sánchez-Gracia, Alejandro (Universitat de Barcelona) ; Rozas, Julio (Universitat de Barcelona) ; Bonifaci, Núria (Institut d'Investigació Biomèdica de Bellvitge) ; McGuffog, Lesley (University of Cambridge) ; Pankratz, Vernon S. (Mayo Clinic, Rochester, Minnesota) ; Islam, Abul (University of Dhaka) ; Mateo, Francesca (Institut d'Investigació Biomèdica de Bellvitge) ; Berenguer, Antoni (Institut d'Investigació Biomèdica de Bellvitge) ; Petit Montserrat, Anna (Institut d'Investigació Biomèdica de Bellvitge) ; Català, Isabel (Institut d'Investigació Biomèdica de Bellvitge) ; Brunet, Joan (Institut d'Investigació Biomèdica (Girona)) ; Feliubadaló, Lidia (Institut d'Investigació Biomèdica de Bellvitge) ; Tornero, Eva (Institut d'Investigació Biomèdica de Bellvitge) ; Benítez, Javier (Centro Nacional de Investigaciones Oncológicas) ; Osorio, Ana (Centro Nacional de Investigaciones Oncológicas) ; Ramon y Cajal, Teresa (Institut d'Investigació Biomèdica Sant Pau) ; Aittomäki, Kristiina (Helsinki University Central Hospital) ; Arun, Banu K. (University of Texas) ; Toland, Amanda E. (The Ohio State University, Columbus) ; Karlan, Beth Y. (Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Los Angeles) ; Walsh, Christine (Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Los Angeles) ; Lester, Jenny (Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Los Angeles) ; Greene, Mark H. (National Cancer Institute, Maryland, Rockville) ; Mai, Phuong L. (National Cancer Institute, Maryland, Rockville) ; Nussbaum, Robert L. (University of California San Francisco, San Francisco) ; Andrulis, Irene L. (Samuel Lunenfeld Research Institute, Mount Sinai Hospital, and Departments of Molecular Genetics and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada) ; Domchek, Susan M. (The University of Pennsylvania School of Medicine, Philadelphia) ; Nathanson, Katherine L. (The University of Pennsylvania School of Medicine, Philadelphia) ; Rebbeck, Timothy R. (Abramson Cancer Center and Center for Clinical Epidemiology and Biostatistics, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America) ; Barkardottir, Rosa B. (Department of Pathology, Landspitali University Hospital and BMC, Faculty of Medicine, University of Iceland, Reykjavik, Iceland) ; Jakubowska, Anna (Pomeranian Medical University, Szczecin) ; Lubinski, Jan (Pomeranian Medical University, Szczecin) ; Durda, Katarzyna (Pomeranian Medical University, Szczecin) ; Jaworska-Bieniek, Katarzyna (Pomeranian Medical University, Szczecin) ; Claes, Kathleen (Ghent University, Ghent) ; Van Maerken, Tom (Ghent University, Ghent) ; Díez, Orland (Vall d'Hebron Institut d'Oncologia) ; Hansen, Thomas V. (Copenhagen University Hospital, Copenhagen) ; Jønson, Lars (Copenhagen University Hospital, Copenhagen) ; Gerdes, Anne-Marie (Copenhagen University Hospital, Copenhagen) ; Ejlertsen, Bent (Copenhagen University Hospital, Copenhagen) ; de la Hoya, Miguel (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ; Caldés, Trinidad (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ; Dunning, Alison M. (University of Cambridge) ; Oliver, Clare (University of Cambridge) ; Fineberg, Elena (University of Cambridge) ; Cook, Margaret (University of Cambridge) ; Peock, Susan (University of Cambridge) ; McCann, Emma (Glan Clwyd Hospital, Rhyl) ; Murray, Alex (Singleton Hospital, Swansea) ; Jacobs, Chris (Guy's and St. Thomas' National Health Service, London) ; Pichert, Gabriella (Guy's and St. Thomas' National Health Service, London) ; Lalloo, Fiona (Central Manchester University Hospitals National Health Service, Manchester) ; Chu, Carol (Yorkshire Regional Genetics Service, Leeds) ; Dorkins, Huw (Kennedy-Galton Centre, Harrow) ; Paterson, Joan (Addenbrookes Hospital (Cambridge, Regne Unit)) ; Ong, Kai-Ren (Birmingham Women's Hospital Healthcare National Health Service, Edgbaston, Birmingham) ; Teixeira, Manuel R. (Universidade do Porto) ; Hogervorst, Frans B. L. (Netherlands Cancer Institute, Amsterdam) ; van der Hout, Annemarie H. (University of Groningen) ; Seynaeve, Caroline (Erasmus University Medical Center, Rotterdam) ; van der Luijt, Rob B. (University Medical Center Utrecht, Utrecht) ; Ligtenberg, Marjolijn J. L. (Radboud university medical center, Nijmegen) ; Devilee, Peter (Leiden University Medical Center, Leiden) ; Wijnen, Juul T. (Leiden University Medical Center, Leiden) ; Rookus, Matti A. (Netherlands Cancer Institute, Amsterdam) ; Meijers-Heijboer, Hanne E. J. (Vrije Universiteit, Amsterdam) ; Blok, Marinus J. (Maastricht University Medical Center) ; van den Ouweland, Ans M. W. (Erasmus University Medical Center, Rotterdam) ; Aalfs, Cora M. (Department of Clinical Genetics, Amsterdam) ; Rodriguez, Gustavo C. (University of Chicago) ; Phillips, Kelly-Anne A. (Peter MacCallum Cancer Centre, East Melbourne) ; Piedmonte, Marion (Roswell Park Cancer Institute, Buffalo, New York) ; Nerenstone, Stacy R. (Hartford Hospital/Helen and Harry Gray Cancer Center) ; Bae-Jump, Victoria L. (University of North Carolina) ; O'Malley, David M. (Ohio State University, Hilliard) ; Ratner, Elena S. (Yale University School of Medicine) ; Schmutzler, Rita K. (Uniklinik Köln (Colònia, Alemanya)) ; Wappenschmidt, Barbara (Uniklinik Köln (Colònia, Alemanya)) ; Rhiem, Kerstin (University Hospital of Cologne, Cologne, Germany) ; Engel, Christoph (University of Leipzig) ; Meindl, Alfons (Technical University Munich) ; Ditsch, Nina (Ludwig-Maximilian University Munich) ; Arnold, Norbert (Kiel University Medical Center Schleswig-Holstein) ; Plendl, Hansjoerg J. (Kiel University Medical Center Schleswig-Holstein) ; Niederacher, Dieter (University Hospital Düsseldorf) ; Sutter, Christian (Heidelberg University Hospital (Alemanya)) ; Wang-Gohrke, Shan (University Hospital of Ulm (Alemanya)) ; Steinemann, Doris (Institute of Cell and Molecular Pathology, Hannover) ; Preisler-Adams, Sabine (University of Münster) ; Kast, Karin (Technical University Dresden) ; Varon-Mateeva, Raymonda (Institute of Human Genetics, Campus Virchov Klinikum, Charite Berlin) ; Gehrig, Andrea (Centre of Familial Breast and Ovarian Cancer, Institute of Human Genetics, University Würzburg, Würzburg, Germany) ; Bojesen, Anders (Vejle Hospital, Vejle) ; Pedersen, Inge Sokilde (Aalborg University Hospital (Dinamarca)) ; Sunde, Lone (Aarhus University Hospital (Aarhus, Dinamarca)) ; Jensen, Uffe Birk (Aarhus University Hospital (Aarhus, Dinamarca)) ; Thomassen, Mads (Odense University Hospital (Dinamarca)) ; Kruse, Torben A. (Odense University Hospital (Dinamarca)) ; Foretova, Lenka (Masaryk Memorial Cancer Institute, Brno) ; Peterlongo, Paolo (Fondazione Istituto di Oncologia MolecolarE, Milan) ; Bernard, Loris (Istituto Europeo di Oncologia, Milan) ; Peissel, Bernard (Fondazione Istituto Nazionale Tumori, Milan) ; Scuvera, Giulietta (Fondazione Istituto Nazionale Tumori, Milan) ; Manoukian, Siranoush (Fondazione Istituto Nazionale Tumori, Milan) ; Radice, Paolo (Fondazione Istituto Nazionale Tumori, Milan) ; Ottini, Laura ("Sapienza" University, Rome) ; Montagna, Marco (Istituto Oncologico Veneto, Padua) ; Agata, Simona (Istituto Oncologico Veneto, Padua) ; Maugard, Christine (Hopitaux Universitaire de Strasbourg) ; Simard, Jacques (Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec City) ; Soucy, Penny (Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec City) ; Berger, Andreas (Medical University of Vienna) ; Fink-Retter, Anneliese (Medical University of Vienna) ; Singer, Christian F. (Medical University of Vienna) ; Rappaport, Christine (Medical University of Vienna) ; Geschwantler-Kaulich, Daphne (Medical University of Vienna) ; Tea, Muy-Kheng (Medical University of Vienna) ; Pfeiler, Georg (Medical University of Vienna) ; John, Esther M. (Cancer Prevention Institute of California) ; Miron, Alex (Dana-Farber Cancer Institute, Boston, Massachusetts) ; Neuhausen, Susan L. (Beckman Research Institute of City of Hope, Duarte) ; Terry, Mary Beth (Columbia University) ; Chung, Wendy K. (Columbia University) ; Daly, Mary B. (Fox Chase Cancer Center, Philadelphia, Pennsylvania) ; Goldgar, David E. (University of Utah School of Medicine, Salt Lake City) ; Janavicius, Ramunas (Vilnius University Hospital Santariskiu Clinics) ; Dorfling, Cecilia M. (University of Pretoria, Arcadia) ; van Rensburg, Elisabeth J. (University of Pretoria, Arcadia) ; Fostira, Florentia (National Centre for Scientific Research Demokritos, Athens) ; Konstantopoulou, Irene (National Centre for Scientific Research Demokritos, Athens) ; Garber, Judy (Harvard Medical School, Boston) ; Godwin, Andrew K. (University of Kansas Medical Center, Kansas City) ; Olah, Edith (National Institute of Oncology, Budapest) ; Narod, Steven A. (University of Toronto) ; Rennert, Gad (Clalit National Israeli Cancer Control Center) ; Paluch, Shani Shimon (Chaim Sheba Medical Center, Ramat Gan) ; Laitman, Yael (Institute of Human Genetics, Ramat Gan) ; Friedman, Eitan (Tel Aviv University, Ramat Aviv) ; Liljegren, Annelie (Karolinska University Hospital, Stockholm) ; Rantala, Johanna (Karolinska University Hospital, Sweeden) ; Stenmark-Askmalm, Marie (Linköping University, Sweeden) ; Loman, Niklas (Lund University Hospital, Sweeden) ; Imyanitov, Evgeny N. (N.N. Petrov Institute of Oncology, St.-Petersburg) ; Hamann, Ute (German Cancer Research Center (DKFZ), Heidelberg) ; Spurdle, Amanda B. (Queensland Institute of Medical Research (QIMR) Berghofer Medical Research Institute, Brisbane) ; Healey, Sue (Queensland Institute of Medical Research (QIMR) Berghofer Medical Research Institute, Brisbane) ; Weitzel, Jeffrey N. (Clinical Cancer Genetics, City of Hope, Duarte, California) ; Herzog, Josef (Clinical Cancer Genetics, City of Hope, Duarte, California) ; Margileth, David (St. Joseph Hospital of Orange, Duarte, California) ; Gorrini, Chiara (University Health Network, Toronto) ; Esteller, Manel (Institució Catalana de Recerca i Estudis Avançats) ; Gómez Moruno, Antonio (Institut d'Investigació Biomèdica de Bellvitge) ; Sayols, Sergi (Institut d'Investigació Biomèdica de Bellvitge) ; Vidal, Enrique (Institut d'Investigació Biomèdica de Bellvitge) ; Heyn, Holger (Institut d'Investigació Biomèdica de Bellvitge) ; Stoppa-Lyonnet, Dominique (Université Paris Descartes, Sorbonne Paris Cité, Paris, France) ; Léoné, Melanie (Hospices Civils de Lyon-Centre Léon Bérard, Lyon) ; Barjhoux, Laure (Université Lyon 1) ; Fassy-Colcombet, Marion (Institut Curie, Paris) ; de Pauw, Antoine (Institut Curie, Paris) ; Lasset, Christine (Université Lyon 1) ; Ferrer, Sandra Fert (Hôtel Dieu Centre Hospitalier, Chambéry) ; Castera, Laurent (Department of Tumour Biology, Institut Curie, Paris) ; Berthet, Pascaline (Centre François Baclesse, Caen, France) ; Cornelis, François (Genetic Unit, Avicenne Hospital, Clermont-Ferrand) ; Bignon, Yves-Jean (Université de Clermont-Ferrand) ; Damiola, Francesca (Centre de Recherche en Cancérologie de Lyon) ; Mazoyer, Sylvie (Centre de Recherche en Cancérologie de Lyon) ; Sinilnikova, Olga M. (Centre de Recherche en Cancérologie de Lyon) ; Maxwell, Christopher A. (University of British Columbia, Vancouver) ; Vijai, Joseph (Memorial Sloan-Kettering Cancer Center, New York) ; Robson, Mark (Memorial Sloan-Kettering Cancer Center, New York) ; Kauff, Noah (Memorial Sloan-Kettering Cancer Center, New York) ; Corines, Marina J. (Memorial Sloan-Kettering Cancer Center, New York) ; Villano, Danylko (Memorial Sloan-Kettering Cancer Center, New York) ; Cunningham, Julie (Mayo Clinic, Rochester, Minnesota, United States of America) ; Lee, Adam (Mayo Clinic, Rochester, Minnesota) ; Lindor, Noralane (Mayo Clinic, Scottsdale, Arizona) ; Lázaro, Conxi (Institut d'Investigació Biomèdica de Bellvitge) ; Easton, Douglas F. (University of Cambridge) ; Offit, Kenneth (Memorial Sloan-Kettering Cancer Center, New York) ; Chenevix-Trench, Georgia (Queensland Institute of Medical Research, Brisbane, Australia) ; Couch, Fergus J. (Mayo Clinic, Rochester, Minnesota) ; Antoniou, Antonis C. (University of Cambridge) ; Pujana, Miguel Angel (Institut d'Investigació Biomèdica de Bellvitge)
While interplay between BRCA1 and AURKA-RHAMM-TPX2-TUBG1 regulates mammary epithelial polarization, common genetic variation in HMMR (gene product RHAMM) may be associated with risk of breast cancer in BRCA1 mutation carriers. [...]
2015 - 10.1371/journal.pone.0120020
PloS one, Vol. 10 (april 2015)  
2.
24 p, 728.4 KB Tax collection in the Roman Empire : a new institutional economics approach / Gutiérrez, Óscar (Universitat Autònoma de Barcelona. Departament d'Empresa) ; Martínez-Esteller, Marco (Universitat Autònoma de Barcelona. Departament d'Empresa)
This paper reviews the Roman tax collection system since the Late Republic to the Principality, focusing on the transition from the tax-farming system to a more centralized, census-based administration. [...]
2021 - 10.1007/s10602-021-09355-5
Constitutional Political Economy, 24 December (2021)  
3.
9 p, 3.7 MB The Genome-wide Methylation Profile of CD4+ T Cells From Individuals With Human Immunodeficiency Virus (HIV) Identifies Distinct Patterns Associated With Disease Progression / Moron-Lopez, Sara (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Urrea, Víctor (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Dalmau, Judith (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Lopez, Miguel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Puertas, Maria C. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Ouchi, Dan (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Gómez Moruno, Antonio (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Passaes, Caroline (Institut Pasteur) ; Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Saez-Cirion, Asier (Institut Pasteur) ; Clotet, Bonaventura (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ; Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Berdasco, Maria (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Martinez-Picado, Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
BACKGROUND: Human genetic variation-mostly in the human leukocyte antigen (HLA) and C-C chemokine receptor type 5 (CCR5) regions-explains 25% of the variability in progression of human immunodeficiency virus (HIV) infection. [...]
2021 - 10.1093/cid/ciaa1047
Clinical Infectious Diseases, Vol. 72 Núm. 9 (april 2021) , p. e256-e264  
4.
12 p, 3.6 MB DNA methylation loss promotes immune evasion of tumours with high mutation and copy number load / Jung, H. (Department of Bio and Brain Engineering. KAIST) ; Kim, H.S. (Division of Hematology/Oncology. Department of Medicine. Samsung Medical Center. Sungkyunkwan University School of Medicine) ; Kim, J.Y. (Department of Bio and Brain Engineering. KAIST) ; Sun, J.M. (Division of Hematology/Oncology. Department of Medicine. Samsung Medical Center. Sungkyunkwan University School of Medicine) ; Ahn, Jin Seop (Division of Hematology/Oncology. Department of Medicine. Samsung Medical Center. Sungkyunkwan University School of Medicine) ; Ahn, M.J. (Division of Hematology/Oncology. Department of Medicine. Samsung Medical Center. Sungkyunkwan University School of Medicine) ; Park, K. (Division of Hematology/Oncology. Department of Medicine. Samsung Medical Center. Sungkyunkwan University School of Medicine) ; Esteller, M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Lee, S.H. (Department of Health Sciences and Technology. Samsung Advanced Institute of Health Science and Technology. Sungkyunkwan University) ; Choi, J.K. (Penta Medix Co.. Ltd.) ; Universitat Autònoma de Barcelona
Mitotic cell division increases tumour mutation burden and copy number load, predictive markers of the clinical benefit of immunotherapy. Cell division correlates also with genomic demethylation involving methylation loss in late-replicating partial methylation domains. [...]
2019 - 10.1038/s41467-019-12159-9
Nature communications, Vol. 10 Núm. 1 (january 2019) , p. 4278  
5.
9 p, 2.0 MB Hsa-miR-210-3p expression in breast cancer and its putative association with worse outcome in patients treated with Docetaxel / Pasculli, B. (Fondazione IRCCS Casa Sollievo della Sofferenza Laboratorio di Oncologia) ; Barbano, R. (Fondazione IRCCS Casa Sollievo della Sofferenza Laboratorio di Oncologia) ; Rendina, M. (Fondazione IRCCS Casa Sollievo della Sofferenza Laboratorio di Oncologia) ; Fontana, Andrea (Fondazione IRCCS Casa Sollievo della Sofferenza. UO di Biostatistica) ; Copetti, Massimiliano (Fondazione IRCCS Casa Sollievo della Sofferenza. UO di Biostatistica) ; Mazza, T. (Fondazione IRCCS Casa Sollievo della Sofferenza. Bioinformatics Unit) ; Valori, V.M. (Fondazione IRCCS Casa Sollievo della Sofferenza. UO di Oncologia) ; Morritti, M. (Fondazione IRCCS Casa Sollievo della Sofferenza. UO di Oncologia) ; Maiello, Evaristo (Fondazione IRCCS Casa Sollievo della Sofferenza. UO di Oncologia) ; Graziano, P. (Fondazione IRCCS Casa Sollievo della Sofferenza. UO di Anatomia Patologica) ; Murgo, R. (Fondazione IRCCS Casa Sollievo della Sofferenza. UO di Chirurgia Senologica) ; Fazio, V.M. (Fondazione IRCCS Casa Sollievo della Sofferenza Laboratorio di Oncologia) ; Esteller, M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Parrella, P. (Fondazione IRCCS Casa Sollievo della Sofferenza Laboratorio di Oncologia) ; Universitat Autònoma de Barcelona
MicroRNA-210-3p is the most prominent hypoxia regulated microRNA, and it has been found significantly overexpressed in different human cancers. We performed the expression analysis of miR-210-3p in a retrospective cohort of breast cancer patients with a median follow-up of 76 months (n = 283). [...]
2019 - 10.1038/s41598-019-51581-3
Scientific reports (Nature Publishing Group), Vol. 9 Núm. 1 (january 2019) , p. 14913  
6.
18 p, 2.5 MB The transcribed pseudogene RPSAP52 enhances the oncofetal HMGA2-IGF2BP2-RAS axis through LIN28B-dependent and independent let-7 inhibition / Oliveira-Mateos, C. (Institut d'Investigació Biomèdica de Bellvitge) ; Sánchez-Castillo, A. (Centro de Investigación Biomédica en Red de Cáncer) ; Soler, Marta (Institut d'Investigació Biomèdica de Bellvitge) ; Obiols-Guardia, A. (Institut d'Investigació Biomèdica de Bellvitge) ; Piñeyro, David (Institut d'Investigació Biomèdica de Bellvitge) ; Boque-Sastre, R. (Cardiff School of Biosciences. Cardiff University) ; Calleja-Cervantes, M.E. (Institut d'Investigació Biomèdica de Bellvitge) ; Castro de Moura, M. (Institut d'Investigació Biomèdica de Bellvitge) ; Martínez Cardús, Anna (Institut d'Investigació Biomèdica de Bellvitge) ; Rubio, T. (Institut d'Investigació Biomèdica de Bellvitge) ; Pelletier, Joffrey (Institut d'Investigació Biomèdica de Bellvitge) ; Martínez-Iniesta, M. (Institut d'Investigació Biomèdica de Bellvitge) ; Herrero-Martín, D. (Institut d'Investigació Biomèdica de Bellvitge) ; Tirado, O.M. (Institut d'Investigació Biomèdica de Bellvitge) ; Gentilella, A. (Universitat de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Villanueva, A. (Institut d'Investigació Biomèdica de Bellvitge) ; Esteller, M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Farré, L. (Laboratory of Experimental Pathology (LAPEX). Gonçalo Moniz Research Center. Oswaldo Cruz Foundation (CPQGM/FIOCRUZ)) ; Guil, Sonia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Universitat Autònoma de Barcelona
One largely unknown question in cell biology is the discrimination between inconsequential and functional transcriptional events with relevant regulatory functions. Here, we find that the oncofetal HMGA2 gene is aberrantly reexpressed in many tumor types together with its antisense transcribed pseudogene RPSAP52. [...]
2019 - 10.1038/s41467-019-11910-6
Nature communications, Vol. 10 Núm. 1 (january 2019) , p. 3979  
7.
4 p, 972.8 KB Molecular portrait of high alpha-fetoprotein in hepatocellular carcinoma : implications for biomarker-driven clinical trials / Montal, R. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Andreu-Oller, C. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Bassaganyas, L. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Esteban-Fabró, Roger (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Moran, Sebastian (Institut d'Investigació Biomèdica de Bellvitge) ; Montironi, C. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Moeini, A. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Pinyol, R. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Peix, J. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Cabellos, L. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Villanueva, A. (Liver Cancer Program. Division of Liver Diseases. Icahn School of Medicine at Mount Sinai) ; Sia, D. (Liver Cancer Program. Division of Liver Diseases. Icahn School of Medicine at Mount Sinai) ; Mazzaferro, V. (University of Milan and Gastrointestinal Surgery and Liver Transplantation Unit. Fondazione IRCCS. Istituto Nazionale dei Tumori) ; Esteller, M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Llovet, J.M. (Institució Catalana de Recerca i Estudis Avançats) ; Universitat Autònoma de Barcelona
The clinical utility of serum alpha-fetoprotein (AFP) in patients with hepatocellular carcinoma (HCC) is widely recognised. However, a clear understanding of the mechanisms of AFP overexpression and the molecular traits of patients with AFP-high tumours are not known. [...]
2019 - 10.1038/s41416-019-0513-7
British Journal of Cancer, Vol. 121 Núm. 4 (13 2019) , p. 340-343  
8.
16 p, 2.3 MB Epigenetic silencing of TGFBI confers resistance to trastuzumab in human breast cancer / Palomeras, S. (Universitat de Girona. Departament de Ciències Mèdiques) ; Díaz-Lagares, Angel (University Clinical Hospital of Santiago(CHUS/SERGAS)) ; Viñas, G. (Institut d'Investigació Biomèdica (Girona)) ; Setien, F. (Hospital Universitari de Bellvitge) ; Ferreira, H.J. (Hospital Universitari de Bellvitge) ; Oliveras, Glòria (Hospital Universitari de Girona Doctor Josep Trueta) ; Crujeiras, A.B. (Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición) ; Hernández, A. (Institut Català d'Oncologia) ; Lum, D.H. (University of Utah. Huntsman Cancer Institute) ; Welm, A.L. (University of Utah. Huntsman Cancer Institute) ; Esteller, M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Puig, T. (Universitat de Girona. Departament de Ciències Mèdiques) ; Universitat Autònoma de Barcelona
Background: Acquired resistance to trastuzumab is a major clinical problem in the treatment of HER2-positive (HER2+) breast cancer patients. The selection of trastuzumab-resistant patients is a great challenge of precision oncology. [...]
2019 - 10.1186/s13058-019-1160-x
Breast cancer research, Vol. 21 Núm. 1 (may 2019) , p. 79  
9.
7 p, 979.5 KB Epigenetic inactivation of the splicing RNA-binding protein CELF2 in human breast cancer / Piqué, L. (Institut d'Investigació Biomèdica de Bellvitge) ; Martinez de Paz, A. (Institut d'Investigació Biomèdica de Bellvitge) ; Piñeyro, D. (Institut d'Investigació Biomèdica de Bellvitge) ; Martínez Cardús, Anna (Institut d'Investigació Biomèdica de Bellvitge) ; Castro de Moura, M. (Institut d'Investigació Biomèdica de Bellvitge) ; Llinàs-Arias, P. (Institut d'Investigació Biomèdica de Bellvitge) ; Setien, F. (Institut d'Investigació Biomèdica de Bellvitge) ; Gomez-Miragaya, J. (Institut d'Investigació Biomèdica de Bellvitge) ; Gonzalez-Suarez, E. (Institut d'Investigació Biomèdica de Bellvitge) ; Sigurdsson, S. (Department of Biochemistry and Molecular Biology. Biomedical Center) ; Jonasson, J.G. (Department of Pathology. Landspitali University Hospital) ; Villanueva, A. (Institut Català d'Oncologia) ; Vidal, A. (Hospital Universitari de Bellvitge) ; Davalos, Veronica (Institut d'Investigació Biomèdica de Bellvitge) ; Esteller, M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Universitat Autònoma de Barcelona
Human tumors show altered patterns of protein isoforms that can be related to the dysregulation of messenger RNA alternative splicing also observed in transformed cells. Although somatic mutations in core spliceosome components and their associated factors have been described in some cases, almost nothing is known about the contribution of distorted epigenetic patterns to aberrant splicing. [...]
2019 - 10.1038/s41388-019-0936-x
Oncogene, Vol. 38 Núm. 45 (july 2019) , p. 7106-7112  
10.
15 p, 2.9 MB MethCORR modelling of methylomes from formalin-fixed paraffin-embedded tissue enables characterization and prognostication of colorectal cancer / Mattesen, T.B. (Aarhus University Hospital (Aarhus, Dinamarca)) ; Rasmussen, M.H. (Aarhus University Hospital (Aarhus, Dinamarca)) ; Sandoval, J. (Instituto de Investigación Sanitaria La Fe) ; Ongen, H. (Genetic Medicine and Development. University of Geneva Medical School-CMU) ; Árnadóttir, S.S. (Aarhus University Hospital (Aarhus, Dinamarca)) ; Gladov, J. (Aarhus University Hospital (Aarhus, Dinamarca)) ; Martínez Cardús, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Castro de Moura, Manuel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Madsen, A.H. (Department of Surgery. Hospitalsenheden Vest) ; Laurberg, S. (Aarhus University Hospital (Aarhus, Dinamarca)) ; Dermitzakis, E.T. (Genetic Medicine and Development. University of Geneva Medical School-CMU) ; Esteller, M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Andersen, C.L. (Aarhus University Hospital (Aarhus, Dinamarca)) ; Bramsen, J.B. (Aarhus University Hospital (Aarhus, Dinamarca)) ; Universitat Autònoma de Barcelona
Transcriptional characterization and classification has potential to resolve the inter-tumor heterogeneity of colorectal cancer and improve patient management. Yet, robust transcriptional profiling is difficult using formalin-fixed, paraffin-embedded (FFPE) samples, which complicates testing in clinical and archival material. [...]
2020 - 10.1038/s41467-020-16000-6
Nature communications, Vol. 11 Núm. 1 (january 2020) , p. 2025  

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1.
167 p, 3.7 MB Alteraciones epigenéticas en modelos murinos y humanos de enfermedad de Alzheimer / Sánchez Mut, Jose Vicente ; Esteller, M, dir. ; Navarro, Xavier (Xavier) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia
La enfermedad de Alzheimer (EA) es una patología neurodegenerativa devastadora. Es la principal causa de demencia en las sociedades occidentales y actualmente no tiene cura. Sus síntomas no son evidentes hasta estados muy avanzados y su origen sigue siendo desconocido. [...]
Alzheimer's disease (AD) is a devastating neurodegenerative disorder. It is the main cause of dementia in Western societies and currently has no cure. Symptoms only appear in late stages and it origin remains unknown. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2014  

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