Results overview: Found 42 records in 0.02 seconds.
Articles, 41 records found
Research literature, 1 records found
Articles 41 records found  1 - 10nextend  jump to record:
1.
12 p, 3.6 MB DNA methylation loss promotes immune evasion of tumours with high mutation and copy number load / Jung, H. (Department of Bio and Brain Engineering. KAIST) ; Kim, H.S. (Division of Hematology/Oncology. Department of Medicine. Samsung Medical Center. Sungkyunkwan University School of Medicine) ; Kim, J.Y. (Department of Bio and Brain Engineering. KAIST) ; Sun, J.M. (Division of Hematology/Oncology. Department of Medicine. Samsung Medical Center. Sungkyunkwan University School of Medicine) ; Ahn, J.S. (Division of Hematology/Oncology. Department of Medicine. Samsung Medical Center. Sungkyunkwan University School of Medicine) ; Ahn, M.J. (Division of Hematology/Oncology. Department of Medicine. Samsung Medical Center. Sungkyunkwan University School of Medicine) ; Park, K. (Division of Hematology/Oncology. Department of Medicine. Samsung Medical Center. Sungkyunkwan University School of Medicine) ; Esteller, M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Lee, S.H. (Department of Health Sciences and Technology. Samsung Advanced Institute of Health Science and Technology. Sungkyunkwan University) ; Choi, J.K. (Penta Medix Co.. Ltd.) ; Universitat Autònoma de Barcelona
Mitotic cell division increases tumour mutation burden and copy number load, predictive markers of the clinical benefit of immunotherapy. Cell division correlates also with genomic demethylation involving methylation loss in late-replicating partial methylation domains. [...]
2019 - 10.1038/s41467-019-12159-9
Nature communications, Vol. 10 Núm. 1 (january 2019) , p. 4278  
2.
9 p, 2.0 MB Hsa-miR-210-3p expression in breast cancer and its putative association with worse outcome in patients treated with Docetaxel / Pasculli, B. (Fondazione IRCCS Casa Sollievo della Sofferenza Laboratorio di Oncologia) ; Barbano, R. (Fondazione IRCCS Casa Sollievo della Sofferenza Laboratorio di Oncologia) ; Rendina, M. (Fondazione IRCCS Casa Sollievo della Sofferenza Laboratorio di Oncologia) ; Fontana, A. (Fondazione IRCCS Casa Sollievo della Sofferenza. UO di Biostatistica) ; Copetti, M. (Fondazione IRCCS Casa Sollievo della Sofferenza. UO di Biostatistica) ; Mazza, T. (Fondazione IRCCS Casa Sollievo della Sofferenza. Bioinformatics Unit) ; Valori, V.M. (Fondazione IRCCS Casa Sollievo della Sofferenza. UO di Oncologia) ; Morritti, M. (Fondazione IRCCS Casa Sollievo della Sofferenza. UO di Oncologia) ; Maiello, E. (Fondazione IRCCS Casa Sollievo della Sofferenza. UO di Oncologia) ; Graziano, P. (Fondazione IRCCS Casa Sollievo della Sofferenza. UO di Anatomia Patologica) ; Murgo, R. (Fondazione IRCCS Casa Sollievo della Sofferenza. UO di Chirurgia Senologica) ; Fazio, V.M. (Fondazione IRCCS Casa Sollievo della Sofferenza Laboratorio di Oncologia) ; Esteller, M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Parrella, P. (Fondazione IRCCS Casa Sollievo della Sofferenza Laboratorio di Oncologia) ; Universitat Autònoma de Barcelona
MicroRNA-210-3p is the most prominent hypoxia regulated microRNA, and it has been found significantly overexpressed in different human cancers. We performed the expression analysis of miR-210-3p in a retrospective cohort of breast cancer patients with a median follow-up of 76 months (n = 283). [...]
2019 - 10.1038/s41598-019-51581-3
Scientific reports (Nature Publishing Group), Vol. 9 Núm. 1 (january 2019) , p. 14913  
3.
18 p, 2.5 MB The transcribed pseudogene RPSAP52 enhances the oncofetal HMGA2-IGF2BP2-RAS axis through LIN28B-dependent and independent let-7 inhibition / Oliveira-Mateos, C. (Cancer Epigenetics and Biology Program (PEBC). Bellvitge Biomedical Research Institute (IDIBELL). L'Hospitalet de Llobregat) ; Sánchez-Castillo, A. (Centro de Investigación Biomédica en Red de Cáncer (CIBERONC). Carlos III Institute of Health (ISCIII)) ; Soler, Marta (Cancer Epigenetics and Biology Program (PEBC). Bellvitge Biomedical Research Institute (IDIBELL). L'Hospitalet de Llobregat) ; Obiols-Guardia, A. (Cancer Epigenetics and Biology Program (PEBC). Bellvitge Biomedical Research Institute (IDIBELL). L'Hospitalet de Llobregat) ; Piñeyro, David (Cancer Epigenetics and Biology Program (PEBC). Bellvitge Biomedical Research Institute (IDIBELL). L'Hospitalet de Llobregat) ; Boque-Sastre, R. (Cardiff School of Biosciences. Cardiff University) ; Calleja-Cervantes, M.E. (Cancer Epigenetics and Biology Program (PEBC). Bellvitge Biomedical Research Institute (IDIBELL). L'Hospitalet de Llobregat) ; Castro de Moura, M. (Cancer Epigenetics and Biology Program (PEBC). Bellvitge Biomedical Research Institute (IDIBELL). L'Hospitalet de Llobregat) ; Martínez Cardús, Anna (Cancer Epigenetics and Biology Program (PEBC). Bellvitge Biomedical Research Institute (IDIBELL). L'Hospitalet de Llobregat) ; Rubio, T. (Laboratory of Cancer Metabolism. ONCOBELL Program. Bellvitge Biomedical Research Institute (IDIBELL). L'Hospitalet de Llobregat) ; Pelletier, Joffrey (Laboratory of Cancer Metabolism. ONCOBELL Program. Bellvitge Biomedical Research Institute (IDIBELL). L'Hospitalet de Llobregat) ; Martínez-Iniesta, M. (Program Against Cancer Therapeutic Resistance (ProCURE). ICO. IDIBELL. L'Hospitalet de Llobregat) ; Herrero-Martín, D. (Sarcoma Research Group. ONCOBELL Program. Bellvitge Biomedical Research Institute (IDIBELL). L'Hospitalet de Llobregat) ; Tirado, O.M. (Sarcoma Research Group. ONCOBELL Program. Bellvitge Biomedical Research Institute (IDIBELL). L'Hospitalet de Llobregat) ; Gentilella, A. (Department of Biochemistry and Physiology. Faculty of Pharmacy. University of Barcelona (UB)) ; Villanueva, A. (Program Against Cancer Therapeutic Resistance (ProCURE). ICO. IDIBELL. L'Hospitalet de Llobregat) ; Esteller, M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Farré, L. (Laboratory of Experimental Pathology (LAPEX). Gonçalo Moniz Research Center. Oswaldo Cruz Foundation (CPQGM/FIOCRUZ)) ; Guil, Sonia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Universitat Autònoma de Barcelona
One largely unknown question in cell biology is the discrimination between inconsequential and functional transcriptional events with relevant regulatory functions. Here, we find that the oncofetal HMGA2 gene is aberrantly reexpressed in many tumor types together with its antisense transcribed pseudogene RPSAP52. [...]
2019 - 10.1038/s41467-019-11910-6
Nature communications, Vol. 10 Núm. 1 (january 2019) , p. 3979  
4.
4 p, 972.8 KB Molecular portrait of high alpha-fetoprotein in hepatocellular carcinoma : implications for biomarker-driven clinical trials / Montal, R. (Translational Research in Hepatic Oncology. Liver Unit. IDIBAPS. CIBERehd. Hospital Clínic. University of Barcelona) ; Andreu-Oller, C. (Translational Research in Hepatic Oncology. Liver Unit. IDIBAPS. CIBERehd. Hospital Clínic. University of Barcelona) ; Bassaganyas, L. (Translational Research in Hepatic Oncology. Liver Unit. IDIBAPS. CIBERehd. Hospital Clínic. University of Barcelona) ; Esteban-Fabró, R. (Translational Research in Hepatic Oncology. Liver Unit. IDIBAPS. CIBERehd. Hospital Clínic. University of Barcelona) ; Moran, Sebastian (Cancer Epigenetics and Biology Program (PEBC). Bellvitge Biomedical Research Institute (IDIBELL). L'Hospitalet) ; Montironi, C. (Translational Research in Hepatic Oncology. Liver Unit. IDIBAPS. CIBERehd. Hospital Clínic. University of Barcelona) ; Moeini, A. (Translational Research in Hepatic Oncology. Liver Unit. IDIBAPS. CIBERehd. Hospital Clínic. University of Barcelona) ; Pinyol, R. (Translational Research in Hepatic Oncology. Liver Unit. IDIBAPS. CIBERehd. Hospital Clínic. University of Barcelona) ; Peix, J. (Translational Research in Hepatic Oncology. Liver Unit. IDIBAPS. CIBERehd. Hospital Clínic. University of Barcelona) ; Cabellos, L. (Translational Research in Hepatic Oncology. Liver Unit. IDIBAPS. CIBERehd. Hospital Clínic. University of Barcelona) ; Villanueva, A. (Liver Cancer Program. Division of Liver Diseases. Icahn School of Medicine at Mount Sinai) ; Sia, D. (Liver Cancer Program. Division of Liver Diseases. Icahn School of Medicine at Mount Sinai) ; Mazzaferro, V. (University of Milan and Gastrointestinal Surgery and Liver Transplantation Unit. Fondazione IRCCS. Istituto Nazionale dei Tumori) ; Esteller, M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Llovet, J.M. (Institució Catalana de Recerca i Estudis Avançats (ICREA)) ; Universitat Autònoma de Barcelona
The clinical utility of serum alpha-fetoprotein (AFP) in patients with hepatocellular carcinoma (HCC) is widely recognised. However, a clear understanding of the mechanisms of AFP overexpression and the molecular traits of patients with AFP-high tumours are not known. [...]
2019 - 10.1038/s41416-019-0513-7
British Journal of Cancer, Vol. 121 Núm. 4 (13 2019) , p. 340-343  
5.
16 p, 2.3 MB Epigenetic silencing of TGFBI confers resistance to trastuzumab in human breast cancer / Palomeras, S. (Universitat de Girona. Departament de Ciències Mèdiques) ; Diaz-Lagares, Á. (University Clinical Hospital of Santiago(CHUS/SERGAS)) ; Viñas, G. (Girona Biomedical Research Institute (IDIBGI)) ; Setien, F. (Hospital Universitari de Bellvitge) ; Ferreira, H.J. (Hospital Universitari de Bellvitge) ; Oliveras, G. (Pathology Department. Dr. Josep Trueta Hospital and Catalan Institute of Health (ICS)) ; Crujeiras, A.B. (CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn)) ; Hernández, A. (Institut Català d'Oncologia) ; Lum, D.H. (University of Utah. Huntsman Cancer Institute) ; Welm, A.L. (University of Utah. Huntsman Cancer Institute) ; Esteller, M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Puig, T. (Universitat de Girona. Departament de Ciències Mèdiques) ; Universitat Autònoma de Barcelona
Background: Acquired resistance to trastuzumab is a major clinical problem in the treatment of HER2-positive (HER2+) breast cancer patients. The selection of trastuzumab-resistant patients is a great challenge of precision oncology. [...]
2019 - 10.1186/s13058-019-1160-x
Breast cancer research, Vol. 21 Núm. 1 (may 2019) , p. 79  
6.
7 p, 979.5 KB Epigenetic inactivation of the splicing RNA-binding protein CELF2 in human breast cancer / Piqué, L. (Cancer Epigenetics and Biology Program (PEBC). Bellvitge Biomedical Research Institute (IDIBELL). L'Hospitalet) ; Martinez de Paz, A. (Cancer Epigenetics and Biology Program (PEBC). Bellvitge Biomedical Research Institute (IDIBELL). L'Hospitalet) ; Piñeyro, D. (Cancer Epigenetics and Biology Program (PEBC). Bellvitge Biomedical Research Institute (IDIBELL). L'Hospitalet) ; Martínez Cardús, Anna (Cancer Epigenetics and Biology Program (PEBC). Bellvitge Biomedical Research Institute (IDIBELL). L'Hospitalet) ; Castro de Moura, M. (Cancer Epigenetics and Biology Program (PEBC). Bellvitge Biomedical Research Institute (IDIBELL). L'Hospitalet) ; Llinàs-Arias, P. (Cancer Epigenetics and Biology Program (PEBC). Bellvitge Biomedical Research Institute (IDIBELL). L'Hospitalet) ; Setien, F. (Cancer Epigenetics and Biology Program (PEBC). Bellvitge Biomedical Research Institute (IDIBELL). L'Hospitalet) ; Gomez-Miragaya, J. (Cancer Epigenetics and Biology Program (PEBC). Bellvitge Biomedical Research Institute (IDIBELL). L'Hospitalet) ; Gonzalez-Suarez, E. (Cancer Epigenetics and Biology Program (PEBC). Bellvitge Biomedical Research Institute (IDIBELL). L'Hospitalet) ; Sigurdsson, S. (Department of Biochemistry and Molecular Biology. Biomedical Center) ; Jonasson, J.G. (Department of Pathology. Landspitali University Hospital) ; Villanueva, A. (Institut Català d'Oncologia) ; Vidal, A. (Department of Pathology. Bellvitge University Hospital) ; Davalos, V. (Cancer Epigenetics and Biology Program (PEBC). Bellvitge Biomedical Research Institute (IDIBELL). L'Hospitalet) ; Esteller, M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Universitat Autònoma de Barcelona
Human tumors show altered patterns of protein isoforms that can be related to the dysregulation of messenger RNA alternative splicing also observed in transformed cells. Although somatic mutations in core spliceosome components and their associated factors have been described in some cases, almost nothing is known about the contribution of distorted epigenetic patterns to aberrant splicing. [...]
2019 - 10.1038/s41388-019-0936-x
Oncogene, Vol. 38 Núm. 45 (july 2019) , p. 7106-7112  
7.
15 p, 2.9 MB MethCORR modelling of methylomes from formalin-fixed paraffin-embedded tissue enables characterization and prognostication of colorectal cancer / Mattesen, T.B. (Department of Molecular Medicine. Aarhus University Hospital) ; Rasmussen, M.H. (Department of Molecular Medicine. Aarhus University Hospital) ; Sandoval, J. (Biomarker and precision medicine Unit. Health Research Institute La Fe (ISSLaFe)) ; Ongen, H. (Genetic Medicine and Development. University of Geneva Medical School-CMU) ; Árnadóttir, S.S. (Department of Molecular Medicine. Aarhus University Hospital) ; Gladov, J. (Department of Molecular Medicine. Aarhus University Hospital) ; Martínez Cardús, Anna (Institut Germans Trias i Pujol) ; Castro de Moura, Manuel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Madsen, A.H. (Department of Surgery. Hospitalsenheden Vest) ; Laurberg, S. (Colorectal Surgical Unit. Department of Surgery. Aarhus University Hospital) ; Dermitzakis, E.T. (Genetic Medicine and Development. University of Geneva Medical School-CMU) ; Esteller, M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Andersen, C.L. (Department of Molecular Medicine. Aarhus University Hospital) ; Bramsen, J.B. (Department of Molecular Medicine. Aarhus University Hospital) ; Universitat Autònoma de Barcelona
Transcriptional characterization and classification has potential to resolve the inter-tumor heterogeneity of colorectal cancer and improve patient management. Yet, robust transcriptional profiling is difficult using formalin-fixed, paraffin-embedded (FFPE) samples, which complicates testing in clinical and archival material. [...]
2020 - 10.1038/s41467-020-16000-6
Nature communications, Vol. 11 Núm. 1 (january 2020) , p. 2025  
8.
17 p, 1.6 MB SirT7 auto-ADP-ribosylation regulates glucose starvation response through mH2A1 / Simonet, Nicolas G. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Thackray, J.K. (Department of Genetics. Human Genetics Institute of New Jersey. Rutgers University) ; Vazquez Prat, Berta Nieves (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Ianni, A. (Max Planck Institute for Heart and Lung Research. Department of Cardiac Development and Remodelling) ; Espinosa-Alcantud, María Dolores (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Morales-Sanfrutos, J. (Universitat Pompeu Fabra) ; Hurtado-Bagès, Sarah. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Sabidó, E. (Universitat Pompeu Fabra) ; Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Tischfield, J. (Department of Genetics. Human Genetics Institute of New Jersey. Rutgers University) ; de la Torre, Carolina (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Esteller, M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Braun, T. (Max Planck Institute for Heart and Lung Research. Department of Cardiac Development and Remodelling) ; Olivella, M. (Bioinformatics and Medical Statistics Group. UST. Universitat de Vic-Universitat Central de Catalunya (UVIC-UCC)) ; Serrano, L. (Department of Science. BMCC. City University of New York (CUNY)) ; Vaquero, Alejandro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Universitat Autònoma de Barcelona
Sirtuins are key players of metabolic stress response. Originally described as deacetylases, some sirtuins also exhibit poorly understood mono-adenosine 5'-diphosphate (ADP)-ribosyltransferase (mADPRT) activity. [...]
2020 - 10.1126/sciadv.aaz2590
Science advances, Vol. 6 Núm. 30 (july 2020) , p. aaz2590  
9.
24 p, 1.6 MB The DNA methylation landscape of hematological malignancies : an update / Blecua, Pedro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Martínez-Verbo, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Esteller, M. (Physiological Sciences Department. School of Medicine and Health Sciences. University of Barcelona) ; Universitat Autònoma de Barcelona
The rapid advances in high-throughput sequencing technologies have made it more evident that epigenetic modifications orchestrate a plethora of complex biological processes. During the last decade, we have gained significant knowledge about a wide range of epigenetic changes that crucially contribute to some of the most aggressive forms of leukemia, lymphoma, and myelodysplastic syndromes. [...]
2020 - 10.1002/1878-0261.12744
Molecular Oncology, Vol. 14 Núm. 8 (january 2020) , p. 1616-1639  
10.
13 p, 2.2 MB Epigenetic regulation of gfi1 in endocrine-related cancers : A role regulating tumor growth / Ashour, N. (Departamento de Biología de Sistemas. Unidad Docente de Bioquímica y Biología Molecular. Universidad de Alcalá) ; Angulo, J.C. (Servicio de Urología. Hospital Universitario de Getafe. Fundación para la Investigación Biomédica del Hospital Universitario de Getafe. Universidad Europea de Madrid) ; González-Corpas, A. (Departamento de Biología de Sistemas. Unidad Docente de Bioquímica y Biología Molecular. Universidad de Alcalá) ; Orea, M.J. (Departamento de Biología de Sistemas. Unidad Docente de Bioquímica y Biología Molecular. Universidad de Alcalá) ; Lobo, M.V.T. (Departamento de Biomedicina y Biotecnología. Universidad de Alcalá. Instituto Ramón y Cajal de Investigaciones Sanitarias (IRYCIS)) ; Colomer, R. (Department of Medicine. Universidad Autónoma de Madrid) ; Colás, B. (Departamento de Biología de Sistemas. Unidad Docente de Bioquímica y Biología Molecular. Universidad de Alcalá) ; Esteller, M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Ropero, S. (Departamento de Biología de Sistemas. Unidad Docente de Bioquímica y Biología Molecular. Universidad de Alcalá) ; Universitat Autònoma de Barcelona
Prostate and breast cancer constitute the most common cancers among men and women worldwide. The aging population is one of the main risk factors for prostate and breast cancer development and accumulating studies link aging with epigenetic changes. [...]
2020 - 10.3390/ijms21134687
International journal of molecular sciences, Vol. 21 Núm. 13 (july 2020) , p. 1-12  

Articles : 41 records found   1 - 10nextend  jump to record:
Research literature 1 records found  
1.
167 p, 3.7 MB Alteraciones epigenéticas en modelos murinos y humanos de enfermedad de Alzheimer / Sánchez Mut, Jose Vicente ; Esteller Badosa, Manel, dir. ; Navarro, Xavier (Xavier) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia
La enfermedad de Alzheimer (EA) es una patología neurodegenerativa devastadora. Es la principal causa de demencia en las sociedades occidentales y actualmente no tiene cura. Sus síntomas no son evidentes hasta estados muy avanzados y su origen sigue siendo desconocido. [...]
Alzheimer's disease (AD) is a devastating neurodegenerative disorder. It is the main cause of dementia in Western societies and currently has no cure. Symptoms only appear in late stages and it origin remains unknown. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2014  

See also: similar author names
4 Esteller, M
9 Esteller, Manel
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