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15 p, 1.4 MB |
Association between Germline Single-Nucleotide Variants in ADME Genes and Major Molecular Response to Imatinib in Chronic Myeloid Leukemia Patients
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Estrada Barreras, Natalia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Zamora, Lurdes (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ferrer-Marín, Francisca (Hospital General Universitario Morales Meseguer (Múrcia)) ;
Palomo Sanchís, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
García, Olga (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Vélez, Patricia (Hospital Duran i Reynals (Barcelona)) ;
De la Fuente, Iris (Hospital Universitari de Girona Doctor Josep Trueta) ;
Sagüés, Miguel (Hospital Universitari de Girona Doctor Josep Trueta) ;
Cabezón, Marta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Cortés, Montserrat (Hospital de Granollers, 08402 Granollers, Spain) ;
Vallansot, Rolando Omar (Hospital Universitari Joan XXIII de Tarragona) ;
Senín-Magán, María Alicia (Hospital Duran i Reynals (Barcelona)) ;
Boque, Concepcion (Hospital Duran i Reynals (Barcelona)) ;
Xicoy, Blanca (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Universitat Autònoma de Barcelona
Imatinib is the most common first-line tyrosine kinase inhibitor (TKI) used to treat chronic-phase chronic myeloid leukemia (CP-CML). However, only a proportion of patients achieve major molecular response (MMR), so there is a need to find biological factors that aid the selection of the optimal therapeutic strategy (imatinib vs. [...]
2022 -  10.3390/jcm11206217
Journal of clinical medicine, Vol. 11 (october 2022)
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10 p, 2.4 MB |
Connected Conservation : Rethinking conservation for a telecoupled world
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Carmenta, Rachel (University of East Anglia. Tyndall Centre for Climate Change Research) ;
Barlow, Jos (Lancaster University) ;
Bastos Lima, Mairon G. (Stockholm Environment Institute (SEI)) ;
Berenguer, Erika (University of Oxford) ;
Choiruzzad, Shofwan (University of Indonesia) ;
Estrada-Carmona, Natalia (Bioversity International) ;
França, Filipe (University of Bristol) ;
Kallis, Giorgos (Universitat Autònoma de Barcelona. Institut de Ciència i Tecnologia Ambientals) ;
Killick, Evan (University of Sussex) ;
Lees, Alexander (Manchester Metropolitan University) ;
Martin, Adrian (University of East Anglia) ;
Pascual, Unai 1973- (Universidad del País Vasco) ;
Pettorelli, Nathalie (Zoological Society of London Institute of Zoology) ;
Reed, James (Center for International Forestry Research (Indonèsia)) ;
Rodriguez, Iokine (University of East Anglia) ;
Steward, Angela M. (Federal University of Para) ;
Sunderland, Terry (University of British Columbia. Center for International Forestry Research) ;
Vira, Bhaskar (University of Cambridge) ;
Zaehringer, Julie G. (University of Bern) ;
Hicks, Christina (Lancaster University. Lancaster Environment Centre)
The convergence of the biodiversity and climate crises, widening of wealth inequality, and most recently the COVID-19 pandemic underscore the urgent need to mobilize change to secure sustainable futures. [...]
2023 - 10.1016/j.biocon.2023.110047
Biological conservation, Vol. 282 (June 2023) , art. 110047
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3.
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7 p, 619.6 KB |
Influence of Telomere length on the achievement of deep molecular response with Imatinib in chronic myeloid Leukemia patients
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Estrada Barreras, Natalia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Xicoy, Blanca (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Beier, Fabian (Uniklinik RWTH Aachen University) ;
García, Olga (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Morales, Cristian (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Boque, Concepcion (Institut Català d'Oncologia) ;
Sagüés, Miguel (Institut Català d'Oncologia) ;
Ferreira, Monica S. Ventura (Uniklinik RWTH Aachen University) ;
Vallansot, Rolando (Institut Català d'Oncologia) ;
Marcé, Silvia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Cabezón, Marta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Brümmendorf, Tim H. (Uniklinik RWTH Aachen University) ;
Zamora, Lurdes (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Tyrosine kinase inhibitors have dramatically changed the outcome of chronic myeloid leukemia (CML), and nowadays, one of the main treatment goals is the achievement of deep molecular responses (DMRs), which can eventually lead to therapy discontinuation approaches. [...]
2021 - 10.1097/HS9.0000000000000657
HemaSphere, Vol. 5 Núm. 12 (30 2021) , p. e657
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4.
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12 p, 900.5 KB |
Impact of Individual Comorbidities on Survival of Patients with Myelofibrosis
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García Fortes, María (Universidad de Málaga) ;
Hernandez-Boluda, Juan Carlos (Hospital Clínic Universitari (València)) ;
Álvarez Larrán, Alberto (Hospital Clínic i Provincial de Barcelona) ;
Raya, José M. (Hospital Universitario de Canarias (La Laguna)) ;
Angona, Anna (Hospital del Mar (Barcelona, Catalunya)) ;
Estrada Barreras, Natalia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fox, Maria Laura (Vall d'Hebron Institut d'Oncologia) ;
Cuevas, Beatriz (Hospital Universitario de Burgos) ;
García Hernández, María C. (Hospital General Universitario de Alicante (Alacant, País Valencià)) ;
Gomez Casares, Maria Teresa (Hospital Universitario de Gran Canaria Dr. Negrín) ;
Ferrer-Marín, Francisca (Hospital General Universitario Morales Meseguer (Múrcia)) ;
Saavedra, Silvana (Institut d'Investigació Biomèdica Sant Pau) ;
Cervantes, Francisco (Hospital Clínic i Provincial de Barcelona) ;
García Delgado, Regina (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia))
The comorbidity burden is an important risk factor for overall survival (OS) in several hematological malignancies. This observational prospective study was conducted to evaluate the impact of individual comorbidities on survival in a multicenter series of 668 patients with primary myelofibrosis (PMF) or MF secondary to polycythemia vera (PPV-MF) or essential thrombocythemia (PET-MF). [...]
2022 - 10.3390/cancers14092331
Cancers, Vol. 14 Núm. 9 (5-1 2022) , p. 2331
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12 p, 1.1 MB |
Impact of bcr-abl1 transcript type on response, treatment-free remission rate and survival in chronic myeloid leukemia patients treated with imatinib
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Marcé, Silvia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Xicoy, Blanca (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
García, Olga (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Cabezón, Marta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Estrada Barreras, Natalia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Vélez, Patrícia (Hospital Duran i Reynals (Hospitalet del Llobregat)) ;
Boque, Concepcion (Hospital Duran i Reynals (Hospitalet del Llobregat)) ;
Sagüés, Miguel (Hospital Universitari de Girona Doctor Josep Trueta) ;
Angona, Anna (Hospital Universitari de Girona Doctor Josep Trueta) ;
Teruel-Montoya, Raúl (Hospital General Universitario Morales Meseguer (Múrcia)) ;
Ferrer-Marín, Francisca (Hospital General Universitario Morales Meseguer (Múrcia)) ;
Amat, Paula (Hospital Clínic Universitari (València)) ;
Hernandez-Boluda, Juan Carlos (Hospital Clínic Universitari (València)) ;
Ibarra, Mariana M. (Hospital Clínico San Carlos (Madrid)) ;
Anguita, Eduardo (Hospital Clínico San Carlos (Madrid)) ;
Cortés, Montserrat (Hospital General de Granollers) ;
Fernández-Ruiz, Andrés (Hospital Duran i Reynals (Hospitalet del Llobregat)) ;
Fontanals, Sandra (Hospital Duran i Reynals (Hospitalet del Llobregat)) ;
Zamora, Lurdes (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Universitat Autònoma de Barcelona
The most frequent BCR-ABL1-p210 transcripts in chronic myeloid leukemia (CML) are e14a2 and e13a2. Imatinib (IM) is the most common first-line tyrosine-kinase inhibitor (TKI) used to treat CML. Some studies suggest that BCR-ABL1 transcript types confer different responses to IM. [...]
2021 - 10.3390/jcm10143146
Journal of clinical medicine, Vol. 10 Núm. 14 (february 2021) , p. 3146
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4 p, 336.0 KB |
Safety and efficacy of asciminib treatment in chronic myeloid leukemia patients in real-life clinical practice
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Garcia-Gutierrez, Valentin (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Luna, Alejandro (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Alonso-Dominguez, Juan M. (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
Estrada Barreras, Natalia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Boque, Concepcion (Institut Català d'Oncologia) ;
Xicoy, Blanca (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Giraldo, Pilar (Hospital Quirónsalud Zaragoza) ;
Angona, Anna (Institut Català d'Oncologia) ;
Álvarez Larrán, Alberto (Hospital Clínic i Provincial de Barcelona) ;
Sanchez-Guijo, Fermin (Instituto de Investigación Biomédica de Salamanca) ;
Ramírez, María José (Hospital Universitario de Jerez (Jerez de la Frontera)) ;
Mora, Elvira (Hospital Universitari i Politècnic La Fe (València)) ;
Vélez, Patricia (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Rosell, Ana (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia)) ;
Colorado Araujo, Mercedes (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ;
Cuevas, Beatriz (Hospital Universitario de Burgos) ;
Sagüés, Miguel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Cortés, Montserrat (Hospital General de Granollers) ;
Pérez-Encinas, Manuel (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
Casado Montero, Luis Felipe (Hospital Virgen de la Salud (Toledo)) ;
Moreno Vega, Melania (Hospital Doctor José Molina Orosa) ;
Serrano, Luis (Consorci Hospitalari Provincial de Castelló) ;
Gomez, Valle (Hospital Universitario de la Princesa (Madrid)) ;
Garcia-Hernandez, Carmen (Hospital General Universitario de Alicante (Alacant, País Valencià)) ;
Lakhwani, Sunil (Hospital Universitario de Canarias (La Laguna)) ;
Paz Coll, Antonio (Hospital Universitario Puerto Real (Cadis)) ;
De Paz, Raquel (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ;
Suarez-Varela, Sara (Hospital Universitario de Jerez (Jerez de la Frontera)) ;
Fernandez-Ruiz, Andrés (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Perez Lopez, Raul (Hospital Universitario Virgen de la Arrixaca (Múrcia)) ;
Ortiz-Fernández, Almudena (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Jiménez-Velasco, Antonio (Hospital Regional Universitario de Málaga) ;
Steegmann-Olmedillas, Juan Luis (Hospital Universitario de la Princesa (Madrid)) ;
Hernandez-Boluda, Juan Carlos (Hospital Clínic i Provincial de Barcelona) ;
Universitat Autònoma de Barcelona
2021 - 10.1038/s41408-021-00420-8
Blood Cancer Journal, Vol. 11 (february 2021)
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7.
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11 p, 1.5 MB |
Comparison of flow-FISH and MM-qPCR telomere length assessment techniques for the screening of telomeropathies
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Ferreira, M. S. V. (University Hospital Aachen (Alemanya)) ;
Kirschner, M. (University Hospital Aachen (Alemanya)) ;
Halfmeyer, I. (University Hospital Aachen (Alemanya)) ;
Estrada Barreras, Natalia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Xicoy, Blanca (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Isfort, S. (University Hospital Aachen (Alemanya)) ;
Vieri, M. (University Hospital Aachen (Alemanya)) ;
Zamora, Lurdes (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Abels, A. (University Hospital Aachen (Alemanya)) ;
Bouillon, A. S. (University Hospital Aachen (Alemanya)) ;
Begemann, M. (Institute of Human Genetics. Medical Faculty. RWTH Aachen University) ;
Schemionek, M. (University Hospital Aachen (Alemanya)) ;
Maurer, A. (University Hospital Aachen (Alemanya)) ;
Koschmieder, Steffen (University Hospital Aachen (Alemanya)) ;
Wilop, S. (University Hospital Aachen (Alemanya)) ;
Panse, J. (University Hospital Aachen (Alemanya)) ;
Brümmendorf, Tim H (University Hospital Aachen (Alemanya)) ;
Beier, F. (University Hospital Aachen (Alemanya)) ;
Universitat Autònoma de Barcelona
Assessment of telomere length (TL) in peripheral blood leukocytes is part of the diagnostic algorithm applied to patients with acquired bone marrow failure syndromes (BMFSs) and dyskeratosis congenita (DKC). [...]
2020 - 10.1111/nyas.14248
Annals of the New York Academy of Sciences, Vol. 1466 Núm. 1 (2020) , p. 93-103
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