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10 p, 790.6 KB |
Angiotensin receptor blockers and β-blockers in Marfan syndrome : an individual patient data meta-analysis of randomised trials
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Pitcher, Alex (University of Oxford) ;
Spata, Enti (University of Oxford) ;
Emberson, Jonathan (University of Oxford) ;
Davies, Kelly (University of Oxford) ;
Halls, Heather (University of Oxford) ;
Holland, Lisa (University of Oxford) ;
Wilson, Kate (University of Oxford) ;
Reith, Christina (University of Oxford) ;
Child, Anne H (Imperial College London) ;
Clayton, Tim (London School of Hygiene & Tropical Medicine) ;
Dodd, Matthew (London School of Hygiene & Tropical Medicine) ;
Flather, Marcus (University of East Anglia) ;
Jin, Xu Yu (John Radcliffe Hospital (Oxford, Regne Unit)) ;
Sandor, George (University of British Columbia) ;
Groenink, Maarten (University of Amsterdam) ;
Mulder, Barbara (University of Amsterdam) ;
Backer, Julie De (Universitair Ziekenhuis Gent) ;
Evangelista Masip, Arturo (Hospital Universitari Vall d'Hebron) ;
Forteza, Alberto (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Teixido-Tura, Gisela (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Boileau, Catherine (Université Paris Cité and Université Sorbonne Paris Nord) ;
Jondeau, Guillaume (Université Paris Cité and Université Sorbonne Paris Nord) ;
Milleron, Olivier (Université Paris Cité and Université Sorbonne Paris Nord) ;
Lacro, Ronald V. (Boston Children's Hospital (Boston, Estats Units d'Amèrica)) ;
Sleeper, Lynn A (Boston Children's Hospital (Boston, Estats Units d'Amèrica)) ;
Chiu, Hsin-Hui (Taipei Tzu Chi Hospital) ;
Wu, Mei-Hwan (National Taiwan University Hospital (Taipei, Taiwan)) ;
Neubauer, Stefan (University of Oxford) ;
Watkins, Hugh (University of Oxford) ;
Dietz, Hal (Johns Hopkins University School of Medicine) ;
Baigent, Colin (University of Oxford) ;
Universitat Autònoma de Barcelona
Angiotensin Receptor Blockers (ARBs) and β-blockers are widely used in the treatment of Marfan syndrome to try to reduce the rate of progressive aortic root enlargement characteristic of this condition, but their separate and joint effects are uncertain. [...]
2022 -  10.1016/S0140-6736(22)01534-3
The Lancet (British), Vol. 400 (august 2022) , p. 822-831
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21 p, 5.9 MB |
Oxidative Stress in Structural Valve Deterioration : A Longitudinal Clinical Study
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Galiñanes, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Casós, Kelly (Hospital Universitari de Bellvitge) ;
Blasco-Lucas, Arnau (Hospital Universitari de Bellvitge) ;
Permanyer, Eduard (Centro Médico Teknon) ;
Máñez, Rafael (Hospital Universitari de Bellvitge) ;
Le Tourneau, Thierry (Université de Nantes) ;
Barquinero, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Schwartz, Simon (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bottio, Tomaso (University Hospital of Padova (Pàdua, Itàlia)) ;
Roussel, Jean Christian (CHU de Nantes) ;
Fellah-Hebia, Imen (CHU de Nantes) ;
Sénage, Thomas (Université de Nantes) ;
Evangelista Masip, Arturo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Badano, Luigi P. (San Luca Hospital(Itàlia)) ;
Ruiz-Majoral, Alejandro (Hospital Universitari de Bellvitge) ;
Galli, Cesare (Avantea and Fondazione Avantea Onlus (Itàlia)) ;
Padler-Karavani, Vered (Tel Aviv University) ;
Soulillou, Jean-Paul (Centre Hospitalier Universitaire de Nantes) ;
Vidal Guitart, Xavier (Hospital Universitari Vall d'Hebron) ;
Cozzi, Emanuele (University Hospital of Padova (Pàdua, Itàlia)) ;
Costa, Cristina (Hospital Universitari de Bellvitge) ;
Universitat Autònoma de Barcelona
The cause of structural valve deterioration (SVD) is unclear. Therefore, we investigated oxidative stress markers in sera from patients with bioprosthetic heart valves (BHVs) and their association with SVD. [...]
2022 - 10.3390/biom12111606
Biomolecules, Vol. 12 (october 2022)
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13 p, 1.7 MB |
False lumen rotational flow and aortic stiffness are associated with aortic growth rate in patients with chronic aortic dissection of the descending aorta : a 4D flow cardiovascular magnetic resonance study
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Ruiz-Muñoz, Aroa (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Guala, Andrea (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Dux-Santoy, Lydia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Teixido-Tura, Gisela (Hospital Universitari Vall d'Hebron) ;
Servato, Maria Luz (Hospital Universitari Vall d'Hebron) ;
Valente, Filipa (Hospital Universitari Vall d'Hebron) ;
Garrido-Oliver, Juan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Galian-Gay, Laura (Hospital Universitari Vall d'Hebron) ;
Gutiérrez García-Moreno, Laura (Hospital Universitari Vall d'Hebron) ;
Fernandez-Galera, Rubén (Hospital Universitari Vall d'Hebron) ;
Casas, Guillem (Hospital Universitari Vall d'Hebron) ;
González-Alujas, Teresa (Hospital Universitari Vall d'Hebron) ;
Cuellar-Calabria, Hug (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Johnson, Kevin M. (University of Wisconsin. Departments of Medical Physics & Radiology) ;
Wieben, Oliver (University of Wisconsin. Departments of Medical Physics & Radiology) ;
Ferreira-Gonzalez, Ignacio (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Evangelista Masip, Arturo (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Rodriguez-Palomares, Jose F (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Patency of the false lumen in chronic aortic dissection (AD) is associated with aortic dilation and long-term aortic events. However, predictors of adverse outcomes in this population are limited. The aim of this study was to evaluate the relationship between aortic growth rate and false lumen flow dynamics and biomechanics in patients with chronic, patent AD. [...]
2022 - 10.1186/s12968-022-00852-6
Journal of Cardiovascular Magnetic Resonance, Vol. 24 (march 2022)
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18 p, 6.2 MB |
Aortic disease in Marfan syndrome is caused by overactivation of sGC-PRKG signaling by NO
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de la Fuente-Alonso, Andrea (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Toral, Marta (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Alfayate, Alvaro (Cardiovascular Proteomics Laboratoy (Madrid)) ;
Ruiz-Rodríguez, María Jesús (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Bonzon-Kulichenko, Elena (Cardiovascular Proteomics Laboratoy) ;
Teixido-Tura, Gisela (Hospital Universitari Vall d'Hebron) ;
Martínez-Martínez, Sara (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Méndez-Olivares, María José (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
López-Maderuelo, Dolores (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
González-Valdés, Ileana (Cardiovascular Proteomics Laboratoy (Madrid)) ;
Garcia-Izquierdo, Eusebio (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Mingo, Susana (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Martín, Carlos E. (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Muiño-Mosquera, Laura (Universitair Ziekenhuis Gent) ;
De Backer, Julie (Universitair Ziekenhuis Gent) ;
Nistal, J. Francisco (Instituto de Investigación Sanitaria Valdecilla (Santander, Cantàbria)) ;
Forteza, Alberto (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Evangelista Masip, Arturo (Hospital Universitari Vall d'Hebron) ;
Vázquez, Jesús (Cardiovascular Proteomics Laboratoy (Madrid)) ;
Campanero, Miguel R. (Centro de Biología Molecular Severo Ochoa) ;
Redondo, Juan Miguel (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Universitat Autònoma de Barcelona
Thoracic aortic aneurysm, as occurs in Marfan syndrome, is generally asymptomatic until dissection or rupture, requiring surgical intervention as the only available treatment. Here, we show that nitric oxide (NO) signaling dysregulates actin cytoskeleton dynamics in Marfan Syndrome smooth muscle cells and that NO-donors induce Marfan-like aortopathy in wild-type mice, indicating that a marked increase in NO suffices to induce aortopathy. [...]
2021 - 10.1038/s41467-021-22933-3
Nature communications, Vol. 12 (may 2021)
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13 p, 207.1 KB |
Chagas Cardiomyopathy : Usefulness of EKG and Echocardiogram in a Non-Endemic Country
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Sánchez-Montalvá, Adrián (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Salvador, Fernando (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodríguez Palomares, José Fernando (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Sulleiro Igual, Elena (Hospital Universitari Vall d'Hebron) ;
Sao-Avilés, Augusto (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Roure, Sílvia (Universitat Autònoma de Barcelona) ;
Valerio, Lluís (Universitat Autònoma de Barcelona) ;
Evangelista Masip, Arturo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Molina, Israel (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Chagas disease (CD) is a major cause of cardiomyopathy in Latin America, and migration movements have now spread the disease worldwide. However, data regarding Chagas cardiomyopathy (CC) and the usefulness of echocardiography in non endemic countries are still scarce. [...]
2016 - 10.1371/journal.pone.0157597
PloS one, Vol. 11 (june 2016)
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20 p, 3.8 MB |
False Lumen Flow Patterns and their Relation with Morphological and Biomechanical Characteristics of Chronic Aortic Dissections. Computational Model Compared with Magnetic Resonance Imaging Measurements
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Rudenick, Paula A. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Segers, Patrick (Ghent University) ;
Pineda, Victor (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Cuellar-Calabria, Hug (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
García-Dorado, David (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Evangelista Masip, Arturo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bijnens, Bart H. (Institució Catalana de Recerca i Estudis Avançats) ;
Universitat Autònoma de Barcelona
Aortic wall stiffness, tear size and location and the presence of abdominal side branches arising from the false lumen (FL) are key properties potentially involved in FL enlargement in chronic aortic dissections (ADs). [...]
2017 - 10.1371/journal.pone.0170888
PloS one, Vol. 12 (january 2017)
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13 p, 924.0 KB |
Fluid-structure interaction simulations outperform computational fluid dynamics in the description of thoracic aorta haemodynamics and in the differentiation of progressive dilation in Marfan syndrome patients
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Pons, Ramon (Universitat Ramon Llull) ;
Guala, Andrea (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodríguez-Palomares, J. F. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Cajas, J. C. (Universidad Nacional Autónoma de México) ;
Dux-Santoy, Lydia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Teixido-Tura, Gisela (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Molins, J. J. (Universitat Ramon Llull) ;
Vázquez, Mariano (ELEM Biotech) ;
Evangelista Masip, Arturo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martorell, Jordi (Universitat Ramon Llull) ;
Universitat Autònoma de Barcelona
Abnormal fluid dynamics at the ascending aorta may be at the origin of aortic aneurysms. This study was aimed at comparing the performance of computational fluid dynamics (CFD) and fluid-structure interaction (FSI) simulations against four-dimensional (4D) flow magnetic resonance imaging (MRI) data; and to assess the capacity of advanced fluid dynamics markers to stratify aneurysm progression risk. [...]
2020 - 10.1098/rsos.191752
Royal Society Open Science, Vol. 7 (february 2020)
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16 p, 3.1 MB |
Unraveling Bicuspid Aortic Valve Enigmas by Multimodality Imaging : Clinical Implications
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Evangelista Masip, Arturo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Galian-Gay, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Guala, Andrea (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Lopez-Sainz, Angela (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Teixido-Tura, Gisela (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ruiz Muñoz, Aroa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Valente, Filipa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gutiérrez García-Moreno, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Fernandez-Galera, Ruben (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Casas, Guillem (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Panaro, Alejandro (Teknon Heart Institute-Quiron Salud) ;
Marigliano, Alba (Teknon Heart Institute-Quiron Salud) ;
Huguet, Marina (Teknon Heart Institute-Quiron Salud) ;
González-Alujas, Teresa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodriguez-Palomares, Jose F (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Multimodality imaging is the basis of the diagnosis, follow-up, and surgical management of bicuspid aortic valve (BAV) patients. Transthoracic echocardiography (TTE) is used in our clinical routine practice as a first line imaging for BAV diagnosis, valvular phenotyping and function, measurement of thoracic aorta, exclusion of other aortic malformations, and for the assessment of complications such are infective endocarditis and aortic. [...]
2022 - 10.3390/jcm11020456
Journal of clinical medicine, Vol. 11 (january 2022)
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13 p, 2.4 MB |
Diagnostic value of quantitative parameters for myocardial perfusion assessment in patients with suspected coronary artery disease by single- and dual-energy computed tomography myocardial perfusion imaging
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Ruiz-Muñoz, Aroa (Universitat Autònoma de Barcelona) ;
Valente, Filipa (Universitat Autònoma de Barcelona) ;
Dux-Santoy, Lydia (Universitat Autònoma de Barcelona) ;
Guala, Andrea (Universitat Autònoma de Barcelona) ;
Teixido-Tura, Gisela (Universitat Autònoma de Barcelona) ;
Galian-Gay, Laura (Universitat Autònoma de Barcelona) ;
Gutiérrez García-Moreno, Laura (Universitat Autònoma de Barcelona) ;
Fernández-Galera, Ruben (Universitat Autònoma de Barcelona) ;
Casas, Guillem (Universitat Autònoma de Barcelona) ;
González-Alujas, Teresa (Universitat Autònoma de Barcelona) ;
Ferreira-Gonzalez, Ignacio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Evangelista Masip, Arturo (Universitat Autònoma de Barcelona) ;
Rodríguez-Palomares, José (Universitat Autònoma de Barcelona)
To compare performance of visual and quantitative analyses for detecting myocardial ischaemia from single- and dual-energy computed tomography (CT) in patients with suspected coronary artery disease (CAD). [...]
2021 - 10.1016/j.ijcha.2021.100721
International journal of cardiology. Heart & vasculature, Vol. 32 (february 2021)
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