Resultats globals: 5 registres trobats en 0.02 segons.
Articles, 5 registres trobats
Articles 5 registres trobats  
1.
18 p, 1.3 MB Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 / Zhang, Q. (St. Rockefeller University) ; Liu, Z. (Rockefeller University) ; Moncada-Velez, M. (Rockefeller University) ; Chen, J. (Rockefeller University) ; Ogishi, M. (Rockefeller University) ; Bigio, B. (Rockefeller University) ; Yang, R. (Rockefeller University) ; Arias, A. A. (Universidad de Antioquia) ; Zhou, Q. (Rockefeller University) ; Han, J. E. (Rockefeller University) ; Ugurbil, A. C. (Rockefeller University) ; Zhang, P. (Rockefeller University) ; Rapaport, F. (Rockefeller University) ; Li, J. (Rockefeller University) ; Spaan, A. N. (University Medical Center Utrecht) ; Boisson, B. (University of Paris) ; Boisson-Dupuis, S. (University of Paris) ; Bustamante, J. (Necker Hospital for Sick Children) ; Puel, A. (University of Paris) ; Ciancanelli, M. J. (Turnstone Biologics) ; Zhang, S. Y. (University of Paris) ; Béziat, V. (University of Paris) ; Jouanguy, E. (University of Paris) ; Abel, L. (INSERM U1163. University of Paris) ; Cobat, A. (University of Paris) ; Casanova, Jean-Laurent (Rockefeller University) ; Bastard, P. (University of Paris) ; Korol, C. (Necker Hospital for Sick Children) ; Rosain, J. (University of Paris) ; Philippot, Q. (APHP Tenon Hospital) ; Chbihi, M. (University of Paris. Imagine Institute) ; Lorenzo, L. (University of Paris. Imagine Institute) ; Bizien, L. (University of Paris. Imagine Institute) ; Neehus, A. L. (University of Paris. Imagine Institute) ; Kerner, G. (University of Paris. Imagine Institute) ; Seeleuthner, Y. (University of Paris. Imagine Institute) ; Manry, J. (University of Paris. Imagine Institute) ; Le Voyer, T. (University of Paris. Imagine Institute) ; Boisson, B. (University of Paris. Imagine Institute) ; Boisson-Dupuis, S. (University of Paris. Imagine Institute) ; Bustamante, J. (Necker Hospital for Sick Children. AP-HP) ; Puel, A. (University of Paris. Imagine Institute) ; Zhang, S. Y. (University of Paris. Imagine Institute) ; Béziat, V. (University of Paris. Imagine Institute) ; Jouanguy, E. (University of Paris) ; Abel, L. (University of Paris) ; Cobat, A. (University of Paris) ; Bastard, P. (University of Paris) ; Rosain, J. (University of Paris) ; Philippot, Q. (APHP Tenon Hospital) ; Chbihi, M. (University of Paris) ; Lorenzo, L. (University of Paris) ; Bizien, L. (University of Paris) ; Neehus, A. L. (University of Paris) ; Kerner, G. (University of Paris) ; Seeleuthner, Y. (University of Paris) ; Manry, J. (University of Paris) ; Le Voyer, T. (University of Paris) ; Boisson, B. (University of Paris) ; Boisson-Dupuis, S. (University of Paris) ; Bustamante, J. (Necker Hospital for Sick Children) ; Puel, A. (University of Paris) ; Zhang, S. Y. (University of Paris) ; Béziat, V. (University of Paris) ; Jouanguy, E. (University of Paris) ; Abel, L. (INSERM U1163. University of Paris) ; Cobat, A. (University of Paris) ; Le Pen, J. (Rockefeller University) ; Schneider, W. M. (Rockefeller University) ; Razooky, B. S. (Rockefeller University) ; Hoffmann, H. H. (Rockefeller University) ; Michailidis, E. (Rockefeller University) ; Rice, C. M. (Rockefeller University) ; Sabli, I. K. D. (Imperial College London) ; Hodeib, S. (Imperial College London) ; Sancho-Shimizu, V. (Imperial College London) ; Bilguvar, K. (Yale School of Medicine) ; Ye, J. (Columbia University) ; Maniatis, T. (New York Genome Center) ; Bolze, A. (Helix) ; Arias, A. A. (Universidad de Antioquia) ; Zhang, Y. (NIAID Clinical Genomics Program) ; Notarangelo, L. D. (National Institute of Allergy and Infectious Diseases (Bethesda, Estats Units d'Amèrica)) ; Su, H. C. (National Institute of Allergy and Infectious Diseases (Bethesda, Estats Units d'Amèrica)) ; Zhang, Y. (NIAID Clinical Genomics Program) ; Notarangelo, L. D. (National Institute of Allergy and Infectious Diseases (Bethesda, Estats Units d'Amèrica)) ; Su, H. C. (National Institute of Allergy and Infectious Diseases (Bethesda, Estats Units d'Amèrica)) ; Onodi, F. (Université de Paris) ; Korniotis, S. (Université de Paris) ; Karpf, L. (Université de Paris. Institut de Recherche Saint-Louis. INSERM U976. Hôpital Saint-Louis) ; Soumelis, V. (AP-HP. Hôpital Saint-Louis. Laboratoire d'Immunologie) ; Bonnet-Madin, L. (Université de Paris. Institut de Recherche Saint-Louis) ; Amara, A. (Université de Paris. Institut de Recherche Saint-Louis) ; Dorgham, Karim (Sorbonne Université. Inserm. Centre d'Immunologie et des Maladies Infectieuses-Paris (CIMI PARIS). Assistance Publique-Hôpitaux de Paris (AP-HP). Hôpital Pitié-Salpêtrière) ; Gorochov, G. (Sorbonne Université) ; Smith, N. (Institut Pasteur) ; Duffy, D. (Institut Pasteur) ; Moens, L. (University Hospitals Leuven (Bèlgica)) ; Meyts, I. (KU Leuven. Department of Immunology. Microbiology and Transplantation) ; Meade, P. (Department of Microbiology) ; Garcia-Sastre, Adolfo (Tisch Cancer Institute) ; Krammer, F. (Department of Microbiology) ; Corneau, A. (Sorbonne Université) ; Masson, C. (Imagine Institute) ; Schmitt, Y. (Imagine Institute) ; Schluter, A. (Neurometabolic Diseases Laboratory) ; Pujol, Aurora (Institut d'Investigació Biomèdica de Bellvitge) ; Khan, T. (Sidra Medicine) ; Marr, N. (Hamad Bin Khalifa University) ; Fellay, Jacques (Swiss Federal Institute of Technology Lausanne) ; Roussel, L. (McGill University Health Centre) ; Vinh, D. C. (McGill University Health Centre) ; Shahrooei, M. (Saeed Pathobiology and Genetic Lab) ; Alosaimi, M. F. (College of Medicine. King Saud University) ; Alsohime, F. ; Hasanato, R. (Department of Pathology and Laboratory Medicine. College of Medicine. King Saud University) ; Mansouri, D. (Shahid Beheshti University of Medical Sciences) ; Al-Saud, H. (National Center of Genomics Technology. King Abdulaziz City for Science and Technology) ; Almourfi, F. (National Center of Genomics Technology. King Abdulaziz City for Science and Technology) ; Al-Mulla, F. (Kuwait University) ; Al-Muhsen, S. Z. (Immunology Research Laboratory. Department of Pediatrics. College of Medicine. King Saud University Medical City. King Saud University) ; Al Turki, S. (Cancer & Blood Research. King Abdullah International Medical Research Center) ; van de Beek, D. (Amsterdam UMC. University Medical Center) ; Biondi, A. (Pediatric Departement. Centro Tettamanti-European Reference Network PaedCan. EuroBloodNet. MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale) ; Bettini, L. R. (Pediatric Departement. Centro Tettamanti-European Reference Network PaedCan. EuroBloodNet. MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale) ; D'Angio, M. (Pediatric Departement. Centro Tettamanti-European Reference Network PaedCan. EuroBloodNet. MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale) ; Bonfanti, P. (Department of Infectious Diseases. San Gerardo Hospital. University of Milano-Bicocca) ; Imberti, L. (CREA Laboratory. Diagnostic Laboratory. ASST Spedali Civili di Brescia) ; Sottini, A. (CREA Laboratory. Diagnostic Laboratory. ASST Spedali Civili di Brescia) ; Paghera, S. (CREA Laboratory. Diagnostic Laboratory. ASST Spedali Civili di Brescia) ; Quiros-Roldan, E. (Department of Infectious and Tropical Diseases. University of Brescia. ASST Spedali di Brescia) ; Rossi, C. (Medical Officer. ASST Spedali Civili di Brescia) ; Oler, A. J. (Bioinformatics and Computational Biosciences Branch. Office of Cyber Infrastructure and Computational Biology. NIAID. NIH) ; Tompkins, M. F. (PRIMER. Uniformed Services University of the Health Sciences) ; Alba, Camille (PRIMER. Uniformed Services University of the Health Sciences) ; Dalgard, C. L. (American Genome Center. Uniformed Services University of the Health Sciences) ; Vandernoot, I. (Center of Human Genetics. Hôpital Erasme. Université Libre de Bruxelles) ; Smits, G. (Center of Human Genetics. Hôpital Erasme. Université Libre de Bruxelles) ; Goffard, J. C. (Department of Internal Medicine. Hôpital Erasme. Université Libre de Bruxelles) ; Migeotte, I. (Hôpital Erasme) ; Haerynck, F. (Department of Paediatric Immunology and Pulmonology. Centre for Primary Immunodeficiency Ghent (CPIG). PID Research Lab. Jeffrey Modell Diagnosis and Research Centre. Ghent University Hospital) ; Soler-Palacín, P. (Hospital Universitari Vall d'Hebron) ; Martin-Nalda, A. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Colobrán Oriol, Roger (Hospital Universitari Vall d'Hebron) ; Morange, P. E. (Aix Marseille Univ) ; Keles, S. (Meram Medical Faculty. Necmettin Erbakan University. Meram Medical Faculty) ; Çölkesen, F. (Department of Infectious Diseases and Clinical Microbiology. Konya Training and Research Hospital) ; Ozcelik, T. (Bilkent University) ; Yasar, K. K. (Departments of Infectious Diseases and Clinical Microbiology. Bakirkoy Dr. Sadi Konuk Training and Research Hospital. University of Health Sciences) ; Senoglu, S. (Departments of Infectious Diseases and Clinical Microbiology. Bakirkoy Dr. Sadi Konuk Training and Research Hospital. University of Health Sciences) ; Karabela, Ş. N. (Departments of Infectious Diseases and Clinical Microbiology. Bakirkoy Dr. Sadi Konuk Training and Research Hospital. University of Health Sciences) ; Rodríguez-Gallego, C. (Hospital Universitario de Gran Canaria Dr. Negrín) ; Novelli, G. (University of Rome "Tor Vergata) ; Hraiech, S. (Intensive Care Unit) ; Tandjaoui-Lambiotte, Y. (Avicenne Hospital) ; Duval, X. (Hôpital Bichat Claude Bernard) ; Laouénan, C. (Hôpital Bichat) ; Duval, X. (Hôpital Bichat Claude Bernard) ; Snow, A. (Uniformed Services University of the Health Sciences) ; Dalgard, C. L. (American Genome Center) ; Milner, J. D. (Columbia University) ; Mogensen, T. H. (Aarhus University) ; Spaan, A. N. (Univer-sity Medical Center Utrecht) ; Bustamante, J. (Necker Hospital for Sick Children) ; Ciancanelli, M. J. (Turnstone Biologics) ; Maniatis, T. (New York Genome Center) ; Soumelis, V. (Hôpital Saint-Louis) ; Nussenzweig, M. (Howard Hughes Medical Institute) ; Garcia-Sastre, Adolfo (Icahn School of Medicine) ; Lifton, R. P. (Yale School of Medicine) ; Foti, Giuseppe (University of Milano-Bicocca) ; Bellani, G. (University of Milano-Bicocca) ; Citerio, Giuseppe (University of Milano-Bicocca) ; Contro, E. (University of Milano-Bicocca) ; Pesci, A. (University of Milano-Bicocca.) ; Valsecchi, M. G. (University of Milano-Bicocca) ; Cazzaniga, M. (University of Milano-Bicocca) ; Abad, Jorge (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Blanco, I. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Rodrigo, C. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Aguilera-Albesa, Sergio (Complejo Hospitalario de Navarra) ; Akcan, O. M. (Necmettin Erbakan University) ; Darazam, I. A. (Shahid Beheshti University of Medical Sciences) ; Aldave, J. C. (Hospital Nacional Edgardo Rebagliati Martins) ; Ramos, M. A. (Parc Sanitari Sant Joan de Déu) ; Nadji, S. A. (Shahid Beheshti University of Medical Sciences) ; Alkan, G. (Selcuk University) ; Allardet-Servent, J. (Hôpital Européen) ; Allende, L. M. (Hospital Universitario 12 de Octubre (Madrid)) ; Alsina, L. (Hospital Sant Joan de Déu (Manresa)) ; Alyanakian, M. A. (Necker Hospital for Sick Children) ; Amador-Borrero, B. (Université de Paris) ; Mouly, S. (Internal Medicine Department. Hôpital Lariboisière. APHP. Université de Paris) ; Sene, D. (Internal Medicine Department. Hôpital Lariboisière. APHP. Université de Paris) ; Amoura, Z. (Internal Medicine Department. Pitié-Salpétrière Hospital) ; Mathian, A. (Internal Medicine Department. Pitié-Salpétrière Hospital) ; Antolí, A. (Hospital Universitari de Bellvitge) ; Blanch, G. R. (Hospital Universitari de Bellvitge) ; Riera, J. S. (Hospital Universitari de Bellvitge) ; Moreno, X. S. (Hospital Universitari de Bellvitge) ; Arslan, S. (Necmettin Erbakan University) ; Assant, S. (Lyon Sud Hospital) ; Auguet, T. (Hospital Universitari Joan XXIII de Tarragona) ; Azot, A. (Private Practice) ; Bajolle, F. (Necker Hospital for Sick Children) ; Bustamante, J. (Necker Hospital for Sick Children) ; Lévy, R. (Necker Hospital for Sick Children) ; Oualha, M. (Necker Hospital for Sick Children) ; Baldolli, A. (Department of Infectious Diseases) ; Ballester, M. (Consorcio Hospital General Universitario) ; Feldman, H. B. (Tel Aviv University) ; Barrou, B. (Sorbonne Université.) ; Beurton, A. (Hôpital Pitié-Salpêtrière) ; Bilbao, A. (Hospital Universitario de Cruces (Barakaldo, País Basc)) ; Blanchard-Rohner, G. (Geneva University Hospitals (Suïssa)) ; Blandinières, A. (Georges Pompidou Hospital) ; Rivet, N. (Georges Pompidou Hospital) ; Blazquez-Gamero, D. (Hospital Universitario 12 de Octubre (Madrid)) ; Bloomfield, M. (Motol University Hospital) ; Bolivar-Prados, Mireia (Hospital de Mataró. Consorci Sanitari del Maresme) ; Clavé, P. (rie, R.) ; Bosteels, C. (Universitair Ziekenhuis Gent) ; Lambrecht, B. N. (Universitair Ziekenhuis Gent) ; van Braeckel, E. (Universitair Ziekenhuis Gent) ; Bousfiha, A. A. (Averroes University Hospital D'Inflammation et d'Allergie. Hassann II University) ; Bouvattier, C. (Endocrinology Unit. APHP Hôpitaux Universitaires Paris-Sud) ; Vincent, A. (Endocrinology Unit. APHP Hôpitaux Universitaires Paris-Sud) ; Boyarchuk, O. (I. Horbachevsky Ternopil National Medical University) ; Bueno, M. R. P. (University of São Paulo) ; Castro, M. V. (University of São Paulo) ; Matos, L. R. B. (University of São Paulo) ; Zatz, M. (Human Genome and Stem-Cell Research Center. University of São Paulo) ; Agra, J. J. C. (Hospital Insular) ; Calimli, S. (Konya State Hospital) ; Capra, R. (Spedali Civili) ; Carrabba, M. (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico) ; Fabio, G. (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico) ; Casasnovas, Carlos (Hospital Universitari de Bellvitge) ; Vélez-Santamaria, V. (Hospital Universitari de Bellvitge) ; Caseris, M. (Hopital Robert Debré) ; Falck, A. (Hopital Robert Debré) ; Poncelet, G. (Hopital Robert Debré) ; Castelle, M. (Necker Enfants Malades Hospital) ; Castelli, F. (University of Brescia) ; de Vera, M. C. (Canarian Health System) ; Catherinot, E. (Hôpital Foch) ; Chalumeau, M. (Necker Hospital for Sick Children) ; Toubiana, J. (Necker Hospital for Sick Children) ; Charbit, B. (Pasteur Institute) ; Li, Z. (Pasteur Institute) ; Pellegrini, S. (Pasteur Institute) ; Cheng, M. P. (McGill University Health Centre) ; Clotet, B. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Codina, A. (Institut de Recerca Sant Joan de Déu) ; Çölkesen, F. (Necmettin Erbakan University) ; Çölkesen, F. (Konya Training and Research Hospital) ; Colobrán Oriol, Roger (Hospital Universitari Vall d'Hebron) ; Comarmond, C. (Pitié-Salpêtrière Hospital) ; Dalmau, D. (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ; Darley, D. R. (Vincent's Hospital Darlinghurst) ; Dauby, N. (Université Libre de Bruxelles) ; Dauger, S. (Robert-Debré University Hospital) ; Le Bourgeois, F. (Robert-Debré University Hospital) ; Levy, M. (Robert-Debré University Hospital) ; de Pontual, L. (Hôpital Jean Verdier) ; Dehban, A. (Sina Medical Complex) ; Delplancq, G. (Centre de Génétique Humaine) ; Demoule, A. (Sorbonne Université Médecine) ; Diehl, J. L. (Georges Pompidou Hospital) ; Dobbelaere, S. (AZ Delta) ; Durand, S. (Institut Jérôme Lejeune) ; Mircher, C. (Institut Jérôme Lejeune) ; Rebillat, A. S. (Institut Jérôme Lejeune) ; Vilaire, M. E. (Institut Jérôme Lejeune) ; Eldars, W. (DMansoura University) ; Elgamal, M. (Mansoura University) ; Elnagdy, M. H. (Mansoura University) ; Emiroglu, M. (Selcuk University) ; Erdeniz, E. H. (Ondokuz Mayıs University) ; Aytekin, S. E. (Necmettin Erbakan University) ; Euvrard, R. (Centre Hospitalier Fleyriat) ; Evcen, R. (Necmettin Erbakan University) ; Faivre, L. (CHU Dijon) ; Fartoukh, M. (APHP Tenon Hospital) ; Philippot, Q. (APHP Tenon Hospital) ; Faure, M. (Sorbonne Universités) ; Arquero, M. F. (Hospital Clínico San Carlos (Madrid)) ; Flores, Carlos (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife)) ; Francois, B. (CHU Limoges) ; Fumadó, V. (Universitat de Barcelona) ; Fusco, F. (Institute of Genetics and Biophysics "Adriano Buzzati-Traverso) ; Ursini, M. V. (Institute of Genetics and Biophysics "Adriano Buzzati-Traverso) ; Solis, B. G. (Hospital Universitario La Paz (Madrid)) ; de Diego, R. P. (Hospital Universitario La Paz (Madrid)) ; van Den Rym, A. M. (Hospital Universitario La Paz (Madrid)) ; Gaussem, P. (Department of Hematology. APHP. Hopital Européen Georges Pompidou. Inserm UMR-S1140) ; Gil-Herrera, J. (Hos-pital General Universitario. Instituto de Investigación Sanitaria "Gregorio Marañón) ; Gilardin, L. (Bégin Military Hospital) ; Alarcon, M. G. (Hospital Sant Joan de Déu (Manresa)) ; Girona-Alarcón, M. (Hospital Sant Joan de Déu (Manresa)) ; Goffard, J. C. (Université Libre de Bruxelles) ; Gok, F. (Necmettin Erbakan University) ; Yosunkaya, A. (Necmettin Erbakan University) ; Thy, M. (Center for Clinical Investigation. Assistance Publique-Hôpitaux de Paris. Bichat-Claude Bernard University Hospital) ; van Agtmael, M. (Department of Infectious Diseases. Amsterdam UMC) ; Bomers, M. (Department of Infectious Diseases. Amsterdam UMC) ; Chouchane, O. (Department of Infectious Diseases. Amsterdam UMC) ; Geerlings, S. (Department of Infectious Diseases. Amsterdam UMC) ; Goorhuis, B. (Department of Infectious Diseases. Amsterdam UMC) ; Grobusch, M. P. (Department of Infectious Diseases. Amsterdam UMC) ; Harris, V. (Department of Infectious Diseases. Amsterdam UMC) ; Hermans, S. M. (Department of Infectious Diseases. Amsterdam UMC) ; Hovius, J. W. (Department of Infectious Diseases. Amsterdam UMC) ; Nellen, J. (Department of Infectious Diseases. Amsterdam UMC) ; Peters, E. (Department of Infectious Diseases. Amsterdam UMC) ; van der Poll, T. (Department of Infectious Diseases. Amsterdam UMC) ; Prins, J. M. (Department of Infectious Diseases. Amsterdam UMC) ; Reijnders, T. (Department of Infectious Diseases. Amsterdam UMC) ; Schinkel, M. (Department of Infectious Diseases. Amsterdam UMC) ; Sigaloff, K. (Department of Infectious Diseases. Amsterdam UMC) ; Stijnis, C. S. (Department of Infectious Diseases. Amsterdam UMC) ; van der Valk, M. (Department of Infectious Diseases. Amsterdam UMC) ; van Vugt, M. (Department of Infectious Diseases. Amsterdam UMC) ; Joost Wiersinga, W. (Department of Infectious Diseases. Amsterdam UMC) ; Algera, A. G. (Department of Intensive Care. Amsterdam UMC) ; van Baarle, F. (Department of Intensive Care. Amsterdam UMC) ; Bos, Lieuwe D. (Department of Intensive Care. Amsterdam UMC) ; Botta, M. (Department of Intensive Care. Amsterdam UMC) ; de Bruin, S. (Department of Intensive Care. Amsterdam UMC) ; Bulle, E. (Department of Intensive Care. Amsterdam UMC) ; Elbers, P. (Department of Intensive Care. Amsterdam UMC) ; Fleuren, L. (Department of Intensive Care. Amsterdam UMC) ; Girbes, A. (Department of Intensive Care. Amsterdam UMC) ; Hagens, L. (Department of Intensive Care. Amsterdam UMC) ; Heunks, L. (Department of Intensive Care. Amsterdam UMC) ; Horn, J. (Department of Intensive Care. Amsterdam UMC) ; van Mourik, N. (Department of Intensive Care. Amsterdam UMC) ; Paulus, F. (Department of Intensive Care. Amsterdam UMC) ; Raasveld, J. (Department of Intensive Care. Amsterdam UMC) ; Schultz, M. J. (Department of Intensive Care. Amsterdam UMC) ; Smit, M. (Department of Intensive Care. Amsterdam UMC) ; Stilma, Willemke (Department of Intensive Care. Amsterdam UMC) ; Thoral, P. (Department of Intensive Care. Amsterdam UMC) ; Tsonas, A. (Department of Intensive Care. Amsterdam UMC) ; de Vries, H. (Department of Intensive Care. Amsterdam UMC) ; Bax, D. (Experimental Immunology. Amsterdam UMC) ; Cloherty, A. (Experimental Immunology. Amsterdam UMC) ; Beudel, M. (Department of Neurology. Amsterdam UMC. Amsterdam Neuroscience) ; Brouwer, M. C. (Department of Neurology. Amsterdam UMC. Amsterdam Neuroscience) ; Koning, R. (Department of Neurology. Amsterdam UMC. Amsterdam Neuroscience) ; van de Beek, D. (Amsterdam UMC. University Medical Center) ; Bogaard, H. J. (Department of Pulmonology. Amsterdam UMC) ; de Brabander, J. (Department of Infectious Diseases. Amsterdam UMC) ; de Bree, G. (Department of Infectious Diseases. Amsterdam UMC) ; Bugiani, M. (Department of Pathology. Amsterdam UMC) ; Geerts, B. (Department of Anesthesiology. Amsterdam UMC) ; Hollmann, M. W. (Department of Anesthesiology. Amsterdam UMC) ; Preckel, B. (Department of Anesthesiology. Amsterdam UMC) ; Veelo, D. (Department of Anesthesiology. Amsterdam UMC) ; Geijtenbeek, T. (Department of Experimental Immunology. Amsterdam UMC) ; Hafkamp, F. (Department of Experimental Immunology. Amsterdam UMC) ; Hamann, J. (Amsterdam UMC Biobank Core Facility. Amsterdam UMC) ; Hemke, R. (Department of Radiology. Amsterdam UMC) ; de Jong, M. D. (Department of Medical Microbiology. Amsterdam UMC) ; Schuurman, A. (Department of Internal Medicine. Amsterdam UMC) ; Teunissen, C. (Neurochemical Laboratory. Amsterdam UMC) ; Vlaar, A. P. J. (Department of Intensive Care. Amsterdam UMC) ; Wouters, D. (Department of Clinical Chemistry. Amsterdam UMC) ; Zwinderman, A. H. (Department of Clinical Epidemiology. Biostatistics and Bioinformatics. Amsterdam UMC) ; Abel, L. (INSERM U1163. University of Paris. Imagine Institute) ; Aiuti, A. (San Raffaele Telethon Institute for Gene Therapy. IRCCS Ospedale San Raffaele) ; Muhsen, S. A. (King Saud University) ; Al-Mulla, F. (Kuwait University) ; Anderson, M. S. (University of California. San Francisco) ; Arias, A. A. (Universidad de Antioquia. Group of Primary Immunodeficiencies) ; Feldman, H. B. (Genetics Institute. Tel Aviv Sourasky Medical Center. Sackler Faculty of Medicine. Tel Aviv University) ; Bogunovic, D. (Icahn School of Medicine) ; Itan, Y. (Icahn School of Medicine) ; Bolze, A. (Helix) ; Cirulli, E. (Helix) ; Barrett, K. S. (Helix) ; Washington, N. (Helix) ; Bondarenko, A. (Shupyk National Medical Academy for Postgraduate Education) ; Bousfiha, A. A. (Clinical Immunology Unit. Pediatric Infectious Disease Departement. Faculty of Medicine and Pharmacy. Averroes University Hospital. LICIA Laboratoire d'Immunologie Clinique. D'Inflammation et d'Allergie. Hassann II University) ; Brodin, P. (Karolinska Institutet (Estocolm, Suècia)) ; Bryceson, Y. (Karolinska Institutet (Estocolm, Suècia)) ; Bustamante, C. D. (Stanford University) ; Butte, M. (University of California) ; Casari, G. (Medical Genetics. IRCCS Ospedale San Raffaele) ; Chakravorty, S. (Emory University. Department of Pediatrics. Children's Healthcare of Atlanta) ; Christodoulou, J. (Murdoch Children's Research Institute) ; Le Mestre, S. (University of São Paulo) ; Condino-Neto, Antonio (University of São Paulo) ; Cooper, M. A. (Washington University School of Medicine) ; Dalgard, C. L. (American Genome Center. Uniformed Services University of the Health Sciences) ; David, A. (Centre for Bioinformatics and System Biology. Department of Life Sciences. Imperial College London. South Kensington Campus) ; DeRisi, J. L. (Chan Zuckerberg Biohub) ; Desai, M. (Bai Jerbai Wadia Hospital for Children) ; Drolet, B. A. (School of Medicine and Public Health. University of Wisconsin) ; Espinosa, S. (Instituto Nacional de Pediatria. (National Institute of Pediatrics)) ; Fellay, Jacques (Swiss Federal Institute of Technology Lausanne) ; Flores, Carlos (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife)) ; Franco, J. L. (University of Antioquia) ; Gregersen, P. K. (Feinstein Institute for Medical Research. Northwell Health USA) ; Haerynck, F. (Department of Paediatric Immunology and Pulmonology. Centre for Primary Immunodeficiency Ghent (CPIG). PID Research Lab. Jeffrey Modell Diagnosis and Research Centre. Ghent University Hospital) ; Hagin, D. (Genetics Institute. Tel Aviv Sourasky Medical Center) ; Halwani, R. (Sharjah Institute of Medical Research. College of Medicine. University of Sharjah) ; Heath, J. (Institute for Systems Biology) ; Henrickson, S. E. (Children's Hospital of Philadelphia (Pennsilvània)) ; Hsieh, E. (Anschutz Medical Campus) ; Imai, K. (Riken) ; Karamitros, T. (Hellenic Pasteur Institute) ; Kisand, K. (University of Tartu) ; Ku, C. L. (Chang Gung University) ; Lau, Y. L. (University of Hong Kong) ; Ling, Y. (Shanghai Public Health Clinical Center. Fudan University) ; Lucas, C. L. (Yale School of Medicine) ; Maniatis, T. (New York Genome Center) ; Mansouri, D. (Shahid Beheshti University of Medical Sciences) ; Marodi, L. (Semmelweis University Budapest) ; Milner, J. (Columbia University Medical Center) ; Mironska, K. (University Clinic for Children's Diseases) ; Morio, T. (Tokyo Medical & Dental University Hospital) ; Notarangelo, L. D. (National Institute of Allergy and Infectious Diseases (Bethesda, Estats Units d'Amèrica)) ; Su, H. C. (National Institute of Allergy and Infectious Diseases (Bethesda, Estats Units d'Amèrica)) ; Novelli, A. (Bambino Gesù Children's Hospital) ; Novelli, G. (Department of Biomedicine and Prevention. University of Rome "Tor Vergata) ; O'Farrelly, C. (Trinity College) ; Okada, S. (Hiroshima University) ; Ozcelik, T. (Bilkent University) ; de Diego, R. P. (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ; Planas, A. M. (IIBB-CSIC. IDIBAPS) ; Prando, C. (Faculdades Pequeno Príncipe. Instituto de Pesquisa Pelé Pequeno Príncipe) ; Pujol, A. (Institut d'Investigació Biomèdica de Bellvitge) ; Quintana-Murci, L. (Institut Pasteur. CNRS. UMR 2000. Collège de France) ; Renia, L. (Infectious Diseases Horizontal Technology Center. Singapore Immunology Network. Agency for Science Technology (A*STAR)) ; Renieri, A. (Medical Genetics. University of Siena) ; Rodríguez-Gallego, C. (Hospital Universitario de Gran Canaria Dr. Negrín) ; Sancho-Shimizu, V. (Imperial College London) ; Sankaran, V. (Boston Children's Hospital (Boston, Estats Units d'Amèrica)) ; Shahrooei, M. (Saeed Pathobiology and Genetic Lab) ; Snow, A. (Uniformed Services University of the Health Sciences) ; Soler-Palacín, P. (Hospital Universitari Vall d'Hebron) ; Spaan, A. N. (Univer-sity Medical Center Utrecht) ; Tangye, S. (Garvan Institute of Medical Research (Darlinghurst, Austràlia)) ; Turvey, S. (University of British Columbia) ; Uddin, F. (Holy Family Red Crescent Medical College. Centre for Precision Therapeutics. NeuroGen Children's Healthcare. Genetics and Genomic Medicine Centre. NeuroGen Children's Healthcare) ; Uddin, M. J. (Centre for Applied Genomics. Department of Genetics and Genome Biology. Hospital for Sick Children) ; van de Beek, D. (Amsterdam UMC. University Medical Center) ; Vazquez, S. E. (University of California) ; Vinh, D. C. (McGill University Health Centre) ; von Bernuth, H. (Charité-Berlin University Hospital Center) ; Zawadzki, P. (Molecular Biophysics Division. Faculty of Physics. A. Mickiewicz University) ; Jing, H. (NIAID Clinical Genomics Program. National Institutes of Health) ; Tung, W. (NIAID Clinical Genomics Program. National Institutes of Health) ; Meguro, K. (NIAID Clinical Genomics Program. National Institutes of Health) ; Shaw, E. (NIAID Clinical Genomics Program. National Institutes of Health) ; Jing, H. (NIAID Clinical Genomics Program. National Institutes of Health) ; Tung, W. (NIAID Clinical Genomics Program. National Institutes of Health) ; Shafer, S. (Laboratory of Immune System Biology. Division of Intramural Research. NIAID. NIH) ; Zheng, L. (Laboratory of Immune System Biology. Division of Intramural Research. NIAID. NIH) ; Zhang, Z. (Laboratory of Immune System Biology. Division of Intramural Research. NIAID. NIH) ; Kubo, S. (Laboratory of Immune System Biology. Division of Intramural Research. NIAID. NIH) ; Chauvin, S. D. (Laboratory of Immune System Biology. Division of Intramural Research. NIAID. NIH) ; Meguro, K. (NIAID Clinical Genomics Program. National Institutes of Health) ; Shaw, E. (NIAID Clinical Genomics Program. National Institutes of Health) ; Lenardo, M. (Laboratory of Immune System Biology. Division of Intramural Research. NIAID. NIH) ; Luthers, C. R. (Department of Pharmacology & Molecular Therapeutics. Uniformed Services University of the Health Sciences) ; Bauman, B. M. (Department of Pharmacology & Molecular Therapeutics. Uniformed Services University of the Health Sciences) ; Shafer, S. (Laboratory of Immune System Biology. Division of Intramural Research. NIAID. NIH) ; Zheng, L. (Laboratory of Immune System Biology. Division of Intramural Research. NIAID. NIH) ; Zhang, Z. (Laboratory of Immune System Biology. Division of Intramural Research. NIAID. NIH) ; Kubo, S. (Laboratory of Immune System Biology. Division of Intramural Research. NIAID. NIH) ; Chauvin, S. D. (Laboratory of Immune System Biology. Division of Intramural Research. NIAID. NIH) ; Lenardo, M. (Laboratory of Immune System Biology. Division of Intramural Research. NIAID. NIH) ; Lack, J. (NIAID Collaborative Bioinformatics Resource. Frederick National Laboratory for Cancer Research. Leidos Biomedical Research. Inc.) ; Karlins, E. (Bioinformatics and Computational Biosciences Branch. Office of Cyber Infrastructure and Computational Biology. NIAID. NIH) ; Hupalo, D. M. (American Genome Center. Uniformed Services University of the Health Sciences) ; Rosenberger, J. (American Genome Center. Uniformed Services University of the Health Sciences) ; Sukumar, G. (American Genome Center. Uniformed Services University of the Health Sciences) ; Wilkerson, M. D. (American Genome Center. Uniformed Services University of the Health Sciences) ; Zhang, X. (American Genome Center. Uniformed Services University of the Health Sciences) ; Universitat Autònoma Barcelona
Clinical outcome upon infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ranges from silent infection to lethal coronavirus disease 2019 (COVID-19). We have found an enrichment in rare variants predicted to be loss-of-function (LOF) at the 13 human loci known to govern Toll-like receptor 3 (TLR3)- and interferon regulatory factor 7 (IRF7)-dependent type I interferon (IFN) immunity to influenza virus in 659 patients with life-threatening COVID-19 pneumonia relative to 534 subjects with asymptomatic or benign infection. [...]
2020 - 10.1126/science.abd4570
Science, Vol. 370 Núm. 6515 (23 2020) , p. eabd4570  
2.
17 p, 2.5 MB Autoantibodies against type I IFNs in patients with life-threatening COVID-19 / Bastard, P. (The Rockefeller University. St. Giles Laboratory of Human Genetics of Infectious Diseases) ; Zhang, Q. (The Rockefeller University. St. Giles Laboratory of Human Genetics of Infectious Diseases) ; Michailidis, E. (The Rockefeller University. Laboratory of Virology and Infectious Disease) ; Hoffmann, H. H. (The Rockefeller University. Laboratory of Virology and Infectious Disease) ; Zhang, Y. (National Institute of Allergy and Infectious Diseases (Maryland, Estats Units d'Amèrica)) ; Dorgham, Karim (Sorbonne Université. Centre d'Immunologie et des Maladies Infectieuses) ; Philippot, Q. (University of Paris. Imagine Institute) ; Rosain, J. (University of Paris. Imagine Institute) ; Béziat, V. (The Rockefeller University. St. Giles Laboratory of Human Genetics of Infectious Diseases) ; Manry, J. (University of Paris. Imagine Institute) ; Shaw, E. (National Institute of Allergy and Infectious Diseases (Maryland, Estats Units d'Amèrica)) ; Haljasmägi, L. (University of Tartu. Institute of Biomedicine and Translational Medicine) ; Peterson, P. (University of Tartu. Institute of Biomedicine and Translational Medicine) ; Lorenzo, L. (University of Paris. Imagine Institute) ; Bizien, L. (University of Paris. Imagine Institute) ; Trouillet-Assant, S. (Lyon University. International Center of Research in Infectiology) ; Dobbs, K. (National Institute of Allergy and Infectious Diseases (Maryland, Estats Units d'Amèrica)) ; de Jesus, A. A. (National Institute of Allergy and Infectious Diseases (Maryland, Estats Units d'Amèrica)) ; Belot, A. (Lyon Immunopathology Federation. Hospices Civils de Lyon) ; Kallaste, A. (Internal Medicine Clinic. Tartu University Hospital) ; Catherinot, E. (Hôpital Foch) ; Tandjaoui-Lambiotte, Y. (Avicenne Hospital. Assistance Publique Hôpitaux de Paris) ; Le Pen, J. (The Rockefeller University. Laboratory of Virology and Infectious Disease) ; Kerner, G. (University of Paris. Imagine Institute) ; Bigio, B. (The Rockefeller University. St. Giles Laboratory of Human Genetics of Infectious Diseases) ; Seeleuthner, Y. (University of Paris. Imagine Institute) ; Yang, R. (The Rockefeller University. St. Giles Laboratory of Human Genetics of Infectious Diseases) ; Bolze, A. (Helix) ; Spaan, A. N. (University Medical Center Utrecht) ; Delmonte, O. M. (National Institute of Allergy and Infectious Diseases (Maryland, Estats Units d'Amèrica)) ; Abers, M. S. (National Institute of Allergy and Infectious Diseases (Maryland, Estats Units d'Amèrica)) ; Aiuti, A. (IRCCS San Raffaele Hospital. Vita-Salute San Raffaele University) ; Casari, G. (Medical Genetics. IRCCS Ospedale San Raffaele) ; Lampasona, V. (IRCCS San Raffaele Hospital. Vita-Salute San Raffaele University) ; Piemonti, L. (IRCCS San Raffaele Hospital. Vita-Salute San Raffaele University) ; Ciceri, F. (IRCCS San Raffaele Hospital. Vita-Salute San Raffaele University) ; Bilguvar, K. (Yale University School of Medicine. Department of Genetics) ; Lifton, R. P. (Rockefeller University. Laboratory of Human Genetics and Genomics) ; Vasse, M. (Consorcio Hospital. General Universitario) ; Smadja, D. M. (Paris University. European Georges Pompidou Hospital) ; Migaud, M. (University of Paris. Imagine Institute) ; Hadjadj, J. (Hôpital Cochin. Department of Internal Medicine) ; Terrier, B. (Université de Paris. Department of Internal Medicine) ; Duffy, D. (Pasteur Institute) ; Quintana-Murci, L. (Institut Pasteur. Collège de France) ; van de Beek, D. (Amsterdam UMC. University Medical Center) ; Roussel, L. (McGill University Health Centre) ; Vinh, D. C. (McGill University Health Centre) ; Tangye, S. (Garvan Institute of Medical Research (Darlinghurst, Austràlia)) ; Haerynck, F. (Ghent University Hospital. (Bèlgica)) ; Dalmau, D. (Fundació Docència i Recerca Mútua Terrassa) ; Martinez-Picado, J. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Brodin, P. (Karolinska Institutet (Estocolm, Suècia)) ; Nussenzweig, M. C. (Howard Hughes Medical Institute) ; Boisson-Dupuis, S. (The Rockefeller University. St. Giles Laboratory of Human Genetics of Infectious Diseases) ; Rodríguez-Gallego, C. (Hospital Universitario de Gran Canaria Dr. Negrín) ; Vogt, G. (University of Paris. Neglected Human Genetics Laboratory) ; Mogensen, T. H. (Aarhus University) ; Oler, A. J. (Bioinformatics and Computational Biosciences Branch. Office of Cyber Infrastructure and Computational Biology. NIAID. NIH) ; Gu, J. (Bioinformatics and Computational Biosciences Branch. Office of Cyber Infrastructure and Computational Biology. NIAID. NIH) ; Burbelo, P. D. (Division of Intramural Research. National Institute of Dental Craniofacial Research (NIDCR). NIH) ; Cohen, J. I. (Laboratory of Infectious Diseases. Division of Intramural Research. NIAID. NIH) ; Biondi, A. (Pediatric Department. Centro Tettamanti-European Reference Network PaedCan. EuroBloodNet. MetabERN-University of Milano-Bicocca-Fondazione MBBMOspedale) ; Bettini, L. R. (Pediatric Department. Centro Tettamanti-European Reference Network PaedCan. EuroBloodNet. MetabERN-University of Milano-Bicocca-Fondazione MBBMOspedale) ; DÁngio, M. (University of Milano-Bicocca. Pediatric Department) ; Bonfanti, P. (University of Milano-Bicocca. Department of Infectious Diseases) ; Rossignol, P. (University of Lorraine. Plurithematic Clinical Investigation Centre) ; Mayaux, J. (APHP Pitié-Salpêtrière Hospital) ; Rieux-Laucat, F. (Laboratory of Immunogenetics of Pediatric Autoimmune Diseases. INSERM. UMR 1163. University of Paris. Imagine Institute) ; Husebye, E. S. (Karolinska Institutet (Estocolm, Suècia). Department of Medicine) ; Fusco, F. (Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso'. IGB-CNR) ; Ursini, M. V. (Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso'. IGB-CNR) ; Imberti, L. (Centro di Ricerca Emato-oncologica AIL (CREA) Laboratory. Diagnostic Department. ASST Spedali Civili di Brescia) ; Sottini, A. (Centro di Ricerca Emato-oncologica AIL (CREA) Laboratory. Diagnostic Department. ASST Spedali Civili di Brescia) ; Paghera, S. (Centro di Ricerca Emato-oncologica AIL (CREA) Laboratory. Diagnostic Department. ASST Spedali Civili di Brescia) ; Quiros-Roldan, E. (Department of Infectious and Tropical Diseases. University of Brescia. ASST Spedali di Brescia) ; Rossi, C. (Direzione Sanitaria. ASST Spedali Civili di Brescia) ; Castagnoli, R. (Department of Pediatrics. Fondazione IRCCS Policlinico San Matteo. University of Pavia) ; Montagna, D. (Department of Clinical. Surgical. Diagnostic and Pediatric Sciences. University of Pavia) ; Licari, A. (Department of Pediatrics. Fondazione IRCCS Policlinico San Matteo. University of Pavia) ; Marseglia, G. L. (Department of Pediatrics. Fondazione IRCCS Policlinico San Matteo. University of Pavia) ; Duval, X. (Centre d'Investigation Clinique. Inserm CIC 1425. Hôpital Bichat Claude Bernard. APHP) ; Ghosn, J. (Hôpital Bichat) ; Tsang, J. S. (Multiscale Systems Biology Section. Laboratory of Immune System Biology. NIAID. NIH) ; Goldbach-Mansky, R. (National Institute of Allergy and Infectious Diseases (Maryland, Estats Units d'Amèrica)) ; Kisand, K. (Institute of Biomedicine and Translational Medicine. University of Tartu) ; Lionakis, M. S. (National Institute of Allergy and Infectious Diseases (Maryland, Estats Units d'Amèrica)) ; Puel, A. (St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. The Rockefeller University) ; Zhang, S. Y. (St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. The Rockefeller University) ; Holland, S. M. (National Institute of Allergy and Infectious Diseases (Maryland, Estats Units d'Amèrica)) ; Gorochov, G. (Département d'Immunologie. AP-HP. Hôpital Pitié-Salpétrière) ; Jouanguy, E. (St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. The Rockefeller University) ; Rice, C. M. (Laboratory of Virology and Infectious Disease. The Rockefeller University) ; Cobat, A. (St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. The Rockefeller University) ; Notarangelo, L. D. (National Institute of Allergy and Infectious Diseases (Maryland, Estats Units d'Amèrica)) ; Abel, L. (St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. The Rockefeller University) ; Su, H. C. (National Institute of Allergy and Infectious Diseases (Maryland, Estats Units d'Amèrica)) ; Casanova, Jean-Laurent (Pediatric Hematology and Immunology Unit. Necker Hospital for Sick Children. AP-HP) ; Arias, A. A. (Universidad de Antioquia. Group of Primary Immunodeficiencies) ; Boisson, B. (Laboratory of Human Genetics of Infectious Diseases. Necker Branch. INSERM U1163. Necker Hospital for Sick Children) ; Boucherit, S. (Laboratory of Human Genetics of Infectious Diseases. Necker Branch. INSERM U1163. Necker Hospital for Sick Children) ; Bustamante, J. (Necker Hospital for Sick Children. AP-HP) ; Chbihi, M. (Laboratory of Human Genetics of Infectious Diseases. Necker Branch. INSERM U1163. Necker Hospital for Sick Children) ; Chen, J. (St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. Rockefeller University) ; Chrabieh, M. (Laboratory of Human Genetics of Infectious Diseases. Necker Branch. INSERM U1163. Necker Hospital for Sick Children) ; Kochetkov, T. (St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. Rockefeller University) ; Le Voyer, T. (Laboratory of Human Genetics of Infectious Diseases. Necker Branch. INSERM U1163. Necker Hospital for Sick Children) ; Liu, D. (St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. Rockefeller University) ; Nemirovskaya, Y. (St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. Rockefeller University) ; Ogishi, M. (St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. Rockefeller University) ; Papandrea, D. (St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. Rockefeller University) ; Patissier, C. (Laboratory of Human Genetics of Infectious Diseases. Necker Branch. INSERM U1163. Necker Hospital for Sick Children) ; Rapaport, F. (St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. Rockefeller University) ; Roynard, M. (Laboratory of Human Genetics of Infectious Diseases. Necker Branch. INSERM U1163. Necker Hospital for Sick Children) ; Vladikine, N. (Laboratory of Human Genetics of Infectious Diseases. Necker Branch. INSERM U1163. Necker Hospital for Sick Children) ; Woollett, M. (St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. Rockefeller University) ; Zhang, P. (St. Giles Laboratory of Human Genetics of Infectious Diseases. Rockefeller Branch. Rockefeller University) ; Kashyap, A. (Laboratory of Clinical Immunology and Microbiology. Division of Intramural Research. NIAID. NIH) ; Ding, L. (Laboratory of Clinical Immunology and Microbiology. Division of Intramural Research. NIAID. NIH) ; Bosticardo, M. (Laboratory of Clinical Immunology and Microbiology. Division of Intramural Research. NIAID. NIH) ; Wang, Q. (Bioinformatics and Computational Biosciences Branch. NIAID Office of Cyber Infrastructure and Computational Biology. NIAID. NIH) ; Ochoa, S. (Laboratory of Clinical Immunology and Microbiology. Division of Intramural Research. NIAID. NIH) ; Liu, H. (Laboratory of Clinical Immunology and Microbiology. Division of Intramural Research. NIAID. NIH) ; Chauvin, S. D. (Laboratory of Immune System Biology. Division of Intramural Research. NIAID. NIH) ; Stack, M. (Laboratory of Clinical Immunology and Microbiology. Division of Intramural Research. NIAID. NIH) ; Koroleva, G. (NIH Center for Human Immunology. NIH) ; Bansal, N. (Multiscale Systems Biology Section. Laboratory of Immune System Biology. NIAID. NIH) ; Dalgard, C. L. (American Genome Center. Uniformed Services University of the Health Sciences) ; Snow, A. L. (Department of Pharmacology & Molecular Therapeutics. Uniformed Services University of the Health Sciences) ; Abad, Jorge (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Aguilera-Albesa, Sergio (Complejo Hospitalario de Navarra) ; Akcan, O. M. (Division of Pediatric Infectious Diseases. Necmettin Erbakan University. Meram Medical Faculty) ; Darazam, I. A. (Department of Infectious Diseases. Loghman Hakim Hospital. Shahid Beheshti University of Medical Sciences) ; Aldave, J. C. (Hospital Nacional Edgardo Rebagliati Martins) ; Ramos, M. A. (Parc Sanitari Sant Joan de Déu) ; Nadji, S. A. (Shahid Beheshti University of Medical Sciences. Virology Research Center) ; Alkan, G. (Division of Pediatric Infectious Diseases. Selcuk University) ; Allardet-Servent, J. (Intensive Care Unit. Hôpital Européen) ; Allende, L. M. (Complutense University. Immunology Department) ; Alsina, L. (Hospital Sant Joan de Déu (Manresa)) ; Alyanakian, M. A. (Department of Biological Immunology. Necker Hospital for Sick Children) ; Amador-Borrero, B. (Université de Paris. Internal Medicine Department) ; Amoura, Z. (Pitié-Salpétrière Hospital. Internal Medicine Department) ; Antolí, A. (Hospital Universitari de Bellvitge) ; Arslan, S. (Necmettin Erbakan University. Division of Clinical Immunology and Allergy) ; Assant, S. (Joint Research Unit. Hospices Civils de Lyon-bio Mérieux. Hospices Civils de Lyon. Lyon Sud Hospital) ; Auguet, T. (Hospital Universitari Joan XXIII de Tarragona) ; Azot, A. (Private Practice) ; Bajolle, F. (Necker Hospital for Sick Children. AP-HP) ; Baldolli, A. (Department of Infectious Diseases. CHU de Caen) ; Ballester, M. ; Feldman, H. B. (Genetics Institute. Tel Aviv Sourasky Medical Center. Sackler Faculty of Medicine. Tel Aviv University) ; Barrou, B. (Department of Urology. Nephrology. Transplantation. APHP-SU. Sorbonne Université. INSERM U 1082) ; Beurton, A. (Service de Médecine Intensive-Réanimation et Pneumologie. APHP Hôpital Pitié-Salpêtrière) ; Bilbao, A. (Hospital Universitario de Cruces (Barakaldo, País Basc)) ; Blanchard-Rohner, G. (Geneva University Hospitals (Suïssa)) ; Blanco, I. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Blandinières, A. (Department of Hematology. Georges Pompidou Hospital. APHP) ; Blazquez-Gamero, D. (Hospital Universitario 12 de Octubre (Madrid)) ; Bloomfield, M. (Charles University. Department of Immunology) ; Bolivar-Prados, Mireia (Centro de Investigación Biomédica en Red de Enfermedades Hepàticas y Digestivas (Ciberehd). Hospital de Mataró. Consorci Sanitari del Maresme) ; Borie, R. (Service de Pneumologie. Hopital Bichat. APHP) ; Bousfiha, A. A. (Clinical Immunology Unit. Pediatric Infectious Disease Department. Faculty of Medicine and Pharmacy. Averroes University Hospital. LICIA Laboratoire d'immunologie Clinique d'inflammation et d'allergie. Hassann Ii University) ; Bouvattier, C. (Endocrinology Unit. APHP Hôpitaux Universitaires Paris-Sud) ; Boyarchuk, O. (Department of Children's Diseases and Pediatric Surgery. I.Horbachevsky Ternopil National Medical University) ; Bueno, M. R. P. (Human Genome and Stem-Cell Research Center. University of São Paulo) ; Bustamante, J. (Necker Hospital for Sick Children. AP-HP) ; Agra, J. J. C. (Hospital Insular) ; Calimli, S. (Division of Critical Care Medicine. Department of Anesthesiology and Reanimation. Konya State Hospital) ; Capra, R. (MS Center. Spedali Civili) ; Carrabba, M. (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico) ; Casasnovas, Carlos (Hospital Universitari de Bellvitge) ; Caseris, M. (Hopital Robert Debré) ; Castelle, M. (Pediatric Immuno-hematology Unit. Necker Enfants Malades Hospital. AP-HP) ; Castelli, F. (Department of Infectious and Tropical Diseases. University of Brescia. ASST Spedali Civili di Brescia) ; de Vera, M. C. (Doctoral Health Care Center. Canarian Health System) ; Castro, M. V. (Human Genome and Stem-Cell Research Center. University of São Paulo) ; Catherinot, E. (Hôpital Foch) ; Chalumeau, M. (Necker Hospital for Sick Children. Paris University. AP-HP) ; Charbit, B. (Pasteur Institute) ; Cheng, M. P. (McGill University Health Centre) ; Clavé, P. (Centro de Investigación Biomédica en Red de Enfermedades Hepàticas y Digestivas (Ciberehd). Hospital de Mataró. Consorci Sanitari del Maresme) ; Clotet, B. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Codina, A. (Clinical Biochemistry. Pathology. Paediatric Neurology. Molecular Medicine Departments and Biobank. Institut de Recerca Sant Joan de Déu. CIBERER-ISCIII) ; Çölkesen, F. (Department of Infectious Diseases and Clinical Microbiology. Konya Training and Research Hospital) ; Colobrán Oriol, Roger (Hospital Universitari Vall d'Hebron) ; Comarmond, C. (Pitié-Salpêtrière Hospital) ; Corsico, A. G. (Respiratory Diseases Division. IRCCS Policlinico San Matteo Foundation. University of Pavia) ; Dalmau, D. (Fundació Docència i Recerca Mútua Terrassa) ; Darley, D. R. (UNSW Medicine. St Vincent's Clinical School. Department of Thoracic Medicine. St Vincent's Hospital Darlinghurst) ; Dauby, N. (CHU Saint-Pierre. Université Libre de Bruxelles (ULB)) ; Dauger, S. (Pediatric Intensive Care Unit. Robert-Debré University Hospital. APHP) ; de Pontual, L. (Sorbonne Paris Nord. Hôpital Jean Verdier. APHP) ; Dehban, A. (Specialized Immunology Laboratory of Dr. Shahrooei. Sina Medical Complex) ; Delplancq, G. (Centre de génétique Humaine. CHU Besançon) ; Demoule, A. (Sorbonne Université Médecine. APHP Sorbonne Université Site Pitié-Salpêtrière) ; Di Sabatino, A. (Department of Internal Medicine. Fondazione IRCCS Policlinico San Matteo. University of Pavia) ; Diehl, J. L. (Intensive Care Unit. Georges Pompidou Hospital. APHP) ; Dobbelaere, S. (Department of Pneumology. AZ Delta) ; Durand, S. (Institut Jérôme Lejeune) ; Eldars, W. (Department of Microbiology and Immunology. Faculty of Medicine. Mansoura University) ; Elgamal, M. (Department of Chest. Faculty of Medicine. Mansoura University) ; Elnagdy, M. H. (Department of Medical Biochemistry and Molecular Biology. Faculty of Medicine. Mansoura University) ; Emiroglu, M. (Faculty of Medicine. Division of Pediatric Infectious Diseases. Selcuk University) ; Erdeniz, E. H. (Division of Pediatric Infectious Diseases. Ondokuz Mayıs University) ; Aytekin, S. E. (Necmettin Erbakan University. Meram Medical Faculty. Division of Pediatric Allergy and Immunology) ; Euvrard, R. (Centre Hospitalier Fleyriat) ; Evcen, R. (Division of Clinical Immunology and Allergy. Department of Internal Medicine. Necmettin Erbakan University. Meram Medical Faculty) ; Fabio, G. (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico) ; Faivre, L. (Centre de Génétique. CHU Dijon) ; Falck, A. (Hopital Robert Debré) ; Fartoukh, M. (APHP Tenon Hospital) ; Faure, M. (Sorbonne Universités. UPMC University of Paris) ; Arquero, M. F. (Hospital Clínico San Carlos (Madrid)) ; Flores, Carlos (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife)) ; Francois, B. (CHU Limoges. Inserm CIC 1435 & UMR 1092) ; Fumadó, V. (Universitat de Barcelona) ; Fusco, F. (Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso'. IGB-CNR) ; Solis, B. G. (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ; Gaussem, P. (Department of Hematology. APHP. Hopital Européen Georges Pompidou. Inserm. UMR-S1140) ; Gil-Herrera, J. (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM)) ; Gilardin, L. (Bégin Military Hospital) ; Alarcon, M. G. (Pediatric Intensive Care Unit. Hospital Sant Joan de Déu) ; Girona-Alarcón, M. (Pediatric Intensive Care Unit. Hospital Sant Joan de Déu) ; Goffard, J. C. (Department of Internal Medicine. Hôpital Erasme. Université Libre de Bruxelles) ; Gok, F. (Division of Critical Care Medicine. Department of Anesthesiology and Reanimation. Necmettin Erbakan University. Meram Medical Faculty) ; González-Montelongo, R. (Genomics Division. Instituto Tecnológico y de Energías Renovables (ITER)) ; Guerder, A. (Assistance Publique Hôpitaux de Paris) ; Gul, Y. (Division of Allergy and Immunology. Necmettin Erbakan University. Meram Medical Faculty) ; Guner, S. N. (Division of Allergy and Immunology. Necmettin Erbakan University. Meram Medical Faculty) ; Gut, M. (Universitat Pompeu Fabra) ; Hadjadj, J. (Department of Internal Medicine. National Reference Center for Rare Systemic Autoimmune Diseases. AP-HP. APHP-CUP. Hôpital Cochin) ; Haerynck, F. (Department of Paediatric Immunology and Pulmonology. Centre for Primary Immunodeficiency Ghent (CPIG). PID Research Laboratory. Jeffrey Modell Diagnosis and Research Centre. Ghent University Hospital) ; Halwani, R. (Sharjah Institute of Medical Research. College of Medicine. University of Sharjah) ; Hammarström, L. (Karolinska Institutet (Estocolm, Suècia). Department of Biosciences and Nutrition) ; Hatipoglu, N. (Pediatric Infectious Diseases Unit. Bakirkoy Dr. Sadi Konuk Training and Research Hospital. University of Health Sciences) ; Hernandez-Brito, E. (Hospital Universitario de Gran Canaria Dr. Negrín) ; Holanda-Peña, M. S. (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ; Horcajada, J. P. (Parc de Salut MAR de Barcelona) ; Hraiech, S. (Intensive Care Unit. APHM) ; Humbert, L. (CHU Lille) ; Iglesias, A. D. (Department of Pediatrics. Columbia University) ; Íñigo-Campos, A. (Genomics Division. Instituto Tecnológico y de Energías Renovables (ITER)) ; Jamme, M. (Centre Hospitalier Intercommunal Poissy Saint Germain en Laye) ; Arranz, M. J. (Fundació Docència i Recerca Mútua Terrassa) ; Jordan, I. (Hospital Sant Joan de Déu. Kids Corona Platfform) ; Kanat, F. (Selcuk University. Faculty of Medicine. Chest Diseases Department) ; Kapakli, H. (Division of Allergy and Immunology. Balikesir Ataturk City Hospital) ; Kara, I. (Division of Critical Care Medicine. Selcuk University. Faculty of Medicine) ; Karbuz, A. (Division of Pediatric Infectious Diseases. Prof. Dr. Cemil Tascıoglu City Hospital) ; Yasar, K. K. (Departments of Infectious Diseases and Clinical Microbiology. Bakirkoy Dr. Sadi Konuk Training and Research Hospital. University of Health Sciences) ; Keles, S. (Meram Medical Faculty. Necmettin Erbakan University. Meram Medical Faculty) ; Demirkol, Y. K. (Health Sciences University. Umraniye Education and Research Hospital) ; Klocperk, A. (Department of Immunology. 2nd Faculty of Medicine. Charles University. University Hospital in Motol) ; Król, Z. J. (Central Clinical Hospital of Ministry of the Interior and Administration in Warsaw) ; Kuentz, P. (Oncobiologie Génétique Bioinformatique. PC Bio. CHU Besançon) ; Kwan, Y. W. M. (Paediatric Infectious Disease Unit. Hospital Authority Infectious Disease Center. Princess Margaret Hospital) ; Lagier, J. C. (Aix Marseille Univ. IRD. MEPHI. IHU Méditerranée Infection) ; Lau, Y. L. (University of Hong Kong) ; Le Bourgeois, F. (Pediatric Intensive Care Unit. Robert-Debré University Hospital. APHP) ; Leo, Y. S. (National Centre for Infectious Diseases) ; Lopez, R. L. (Hospital Universitario Reina Sofía (Córdoba, Espanya)) ; Leung, D. (Department of Paediatrics and Adolescent Medicine. University of Hong Kong) ; Levin, M. (Imperial College) ; Levy, M. (Pediatric Intensive Care Unit. Robert-Debré University Hospital. APHP) ; Lévy, R. (Necker Hospital for Sick Children. AP-HP) ; Li, Z. (Pasteur Institute) ; Linglart, A. (AP-HP. Bicêtre Paris-Saclay Hospital) ; Lorenzo-Salazar, J. M. (Genomics Division. Instituto Tecnológico y de Energías Renovables (ITER)) ; Louapre, C. (Neurology Unit. APHP Pitié-Salpêtrière Hospital. Paris University) ; Lubetzki, C. (Neurology Unit. APHP Pitié-Salpêtrière Hospital. Paris University) ; Luyt, C. E. (Inten-sive Care Unit. APHP Pitié-Salpêtrière Hospital. Paris University) ; Lye, D. C. (National Centre for Infectious Diseases. Tan Tock Seng Hospital. Yong Loo Lin School of Medicine. Lee Kong Chian School of Medicine) ; Mansouri, D. (Shahid Beheshti University of Medical Sciences) ; Marjani, M. (Clinical Tuberculosis and Epidemiology Research Center. National Research Institute of Tuberculosis and Lung Diseases (NRITLD). Shahid Beheshti University of Medical Sciences) ; Pereira, J. M. (Hospital Sant Joan de Déu. University of Barcelona) ; Martin, A. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Pueyo, D. M. (Universitat de Barcelona. Hospital Mútua de Terrassa) ; Martinez-Picado, J. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Marzana, I. (Hospital Universitario de Cruces (Barakaldo, País Basc)) ; Mathian, A. (Internal Medicine Department. Pitié-Salpétrière Hospital) ; Matos, L. R. B. (Human Genome and Stem-Cell Research Center. University of São Paulo) ; Matthews, G. V. (University of New South Wales) ; Mayaux, J. (APHP Pitié-Salpêtrière Hospital) ; Mège, J. L. (Aix-Marseille University. APHM) ; Melki, I. (Robert Debré Hospital) ; Meritet, J. F. (APHP Cohin Hospital) ; Metin, O. (Necmettin Erbakan University Meram Faculty of Medicine. Department of Pediatric Infectious Diseases) ; Meyts, I. (KU Leuven. Department of Immunology. Microbiology and Transplantation) ; Mezidi, M. (Hospices Civils de Lyon. Hôpital de la Croix-Rousse) ; Migeotte, I. (Hôpital Erasme) ; Millereux, M. (CH Gonesse) ; Mirault, T. (Vascular Medicine. Georges Pompidou Hospital. APHP) ; Mircher, C. (Institut Jérôme Lejeune) ; Mirsaeidi, M. (Division of Pulmonary and Critical Care. University of Miami) ; Melián, A. M. (Guanarteme Health Care Center. Canarian Health System) ; Martinez, A. M. (Hospital Regional Universitario de Málaga) ; Morange, P. (Aix-Marseille Université) ; Mordacq, C. (CHU Lille) ; Morelle, G. (Department of General Paediatrics. Hôpital Bicêtre. AP-HP. University of Paris Saclay) ; Mouly, S. (Internal Medicine Department. Hôpital Lariboisière. APHP. Université de Paris) ; Muñoz-Barrera, A. (Genomics Division. Instituto Tecnológico y de Energías Renovables (ITER)) ; Nafati, C. (CHU de La Timone) ; Neves, J. F. (Centro Hospitalar Universitário de Lisboa Central) ; Ng, L. F. P. (Singapore Immunology Network) ; Medina, Y. N. (Department of Pediatrics. Complejo Hospitalario Universitario Insular-Materno Infantil. Canarian Health System) ; Cuadros, E. N. (Hospital Regional Universitario de Málaga) ; Gonzalo Ocejo-Vinyals, J. (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ; Orbak, Z. (Ataturk University Medical Faculty) ; Oualha, M. (Necker Hospital for Sick Children. AP-HP) ; Ozcelik, T. (Bilkent University) ; Hammarström, Q. P. (Karolinska Institutet (Estocolm, Suècia). Department of Laboratory Medicine) ; Parizot, C. (APHP Pitié-Salpêtrière Hospital) ; Pascreau, T. (L'Hôpital Foch) ; Paz-Artal, E. (Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12)) ; de Diego, R. P. (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ; Philippe, A. (APHP Hôpitaux Universitaires Paris-Sud) ; Philippota, Q. (APHP Tenon Hospital) ; Planas-Serra, L. (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Ploin, D. (Hospices Civils de Lyon) ; Poissy, J. (Université de Lille. Inserm U1285. CHU Lille) ; Poncelet, G. (Hopital Robert Debré) ; Pouletty, M. (Department of General Pediatrics. University Hospital Robert Debré. APHP) ; Quentric, P. (APHP Pitié-Salpêtrière Hospital) ; Raoult, D. (Aix-Marseille University. APHM) ; Rebillat, A. S. (Institut Jérôme Lejeune) ; Reisli, I. (Necmettin Erbakan University) ; Ricart, P. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Richard, J. C. (Medical Intensive Care Unit. Hopital de la Croix-Rousse. Hospices Civils de Lyon) ; Rivet, N. (Department of Hematology. Georges Pompidou Hospital. APHP) ; Rivière, J. G. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Blanch, G. R. (Hospital Universitari de Bellvitge) ; Rodrigo, C. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Rodriguez-Gallego, C. (University Fernando Pessoa Canarias) ; Rodríguez-Palmero, A. (Institut d'Investigació Biomèdica de Bellvitge) ; Romero, C. S. (Consorcio Hospital. General Universitario) ; Rothenbuhler, A. (APHP Hôpitaux Universitaires Paris-Sud) ; Rozenberg, F. (Virology Unit. Université de Paris. Cohin Hospital. APHP) ; del Prado, M. Y. R. (Hospital San Pedro de Alcántara) ; Riera, J. S. (Hospital Universitari de Bellvitge) ; Sanchez, O. (Respiratory Medicine. Georges Pompidou Hospital. APHP) ; Sánchez-Ramón, S. (Hospital Clínico San Carlos (Madrid)) ; Schluter, A. (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Schmidt, M. (Service de Médecine Intensive Réanimation. Institut de Cardiologie. Hopital Pitié-Salpêtrière) ; Schweitzer, C. E. (CHRU de Nancy. Hôpital d'Enfants) ; Scolari, F. (Chair of Nephrology. University of Brescia) ; Sediva, A. (Department of Immunology. 2nd Faculty of Medicine. Charles University. Motol University Hospital) ; Seijo, L. M. (Clínica Universidad de Navarra) ; Sene, D. (Internal Medicine Department. Hôpital Lariboisière. APHP. Université de Paris) ; Senoglu, S. (Departments of Infectious Diseases and Clinical Microbiology. Bakirkoy Dr. Sadi Konuk Training and Research Hospital. University of Health Sciences) ; Seppänen, M. R. J. (Helsinki University Hospital (Finlàndia)) ; Ilovich, A. S. (Fundació Docència i Recerca Mútua Terrassa) ; Shahrooei, M. (Saeed Pathobiology and Genetic Laboratory) ; Smadja, D. (Hopital Européen Georges Pompidou) ; Sobh, A. (Department of Pediatrics. Faculty of Medicine. Mansoura University) ; Moreno, X. S. (Hospital Universitari de Bellvitge) ; Solé-Violán, J. (Hospital Universitario de Gran Canaria Dr. Negrín) ; Soler, C. (CHU de Saint Etienne) ; Soler-Palacín, P. (Hospital Universitari Vall d'Hebron) ; Stepanovskiy, Y. (Shupyk National Medical Academy for Postgraduate Education) ; Stoclin, A. (Gustave Roussy Cancer Campus) ; Taccone, F. (Hôpital Erasme) ; Tandjaoui-Lambiottea, Y. (Intensive Care Unit. Avicenne Hospital. APHP) ; Taupin, J. L. (Instituto de Biomedicina de Sevilla) ; Tavernier, S. J. (Department of Internal Diseases and Pediatrics. Primary Immune Deficiency Research Laboratory. Centre for Primary Immunodeficiency Ghent. Jeffrey Modell Diagnosis and Research Centre. Ghent University Hospital) ; Terrier, B. (Department of Internal Medicine. Université de Paris. INSERM U970. PARCC) ; Thumerelle, C. (CHU Lille) ; Tomasoni, G. (University of Brescia) ; Toubiana, J. (Necker Hospital for Sick Children. Paris University) ; Alvarez, J. T. (Universitat de Barcelona. Hospital Mútua de Terrassa) ; Trouillet-Assanta, S. (Hospices Civils de Lyon. Lyon Sud Hospital) ; Troya, J. (Hospital Universitario Infanta Leonor) ; Tucci, A. (Hematology Department. ASST Spedali Civili di Brescia) ; Ursini, M. V. (Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso'. IGB-CNR) ; Uzunhan, Y. (Université Sorbonne Paris Nord) ; Vabres, P. (Université de Bourgogne) ; Valencia-Ramos, J. (Hospital Universitario de Burgos) ; van Den Rym, A. M. (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ; Vandernoot, I. (Center of Human Genetics. Hôpital Erasme. Université Libre de Bruxelles) ; Vatansev, H. (Necmettin Erbakan University. Meram Medical Faculty) ; Vélez-Santamaria, V. (Hospital Universitari de Bellvitge) ; Viel, S. (Hospices Civils de Lyon) ; Vilain, C. (CHU de Caen) ; Vilaire, M. E. (Institut Jérôme Lejeune) ; Vincent, A. (Endocrinology Unit. APHP Hôpitaux Universitaires Paris-Sud) ; Voiriot, G. (Sorbonne Université. Service de Médecine Intensive Réanimation) ; Vuotto, F. (CHU Lille) ; Yosunkaya, A. (Division of Critical Care Medicine. Department of Anesthesiology and Reanimation. Necmettin Erbakan University. Meram Medical Faculty) ; Young, B. E. (National Centre for Infectious Diseases) ; Yucel, F. (General Intensive Care Unit. Konya Training and Research Hospital) ; Zannad, F. (CHU de Nancy) ; Zatz, M. (Human Genome and Stem-Cell Research Center. University of São Paulo) ; Belota, A. (University of Lyon) ; Foti, Giuseppe (University of Milano-Bicocca. San Gerardo Hospital) ; Bellani, G. (University of Milano-Bicocca. San Gerardo Hospital) ; Citerio, Giuseppe (University of Milano-Bicocca. San Gerardo Hospital) ; Contro, E. (Necker Hospital for Sick Children) ; Pesci, A. (University of Milano-Bicocca. San Gerardo Hospital) ; Valsecchi, M. G. (University of Milano-Bicocca. San Gerardo Hospital) ; Cazzaniga, M. (University of Milano-Bicocca. San Gerardo Hospital) ; Bole-Feysot, C. (Université de Paris) ; Lyonnet, S. (Université de Paris) ; Masson, C. (Université de Paris) ; Nitschke, P. (Université de Paris) ; Pouliet, A. (Université de Paris) ; Schmitt, Y. (Université de Paris) ; Tores, F. (Université de Paris) ; Zarhrate, M. (Université de Paris) ; Abela, L. (Inserm. UMR 1163) ; Andrejak, C. (CHU Amiens) ; Angoulvant, F. (Hôpital Necker) ; Bachelet, D. (Hôpital Bichat) ; Basmaci, R. (Hôpital Louis Mourrier) ; Behillil, S. (Université de Paris) ; Beluze, M. (Université de Paris) ; Benkerrou, D. (Inserm) ; Bhavsar, K. (Hôpital Bichat) ; Bompart, F. (Drugs for Neglected Diseases Initiative) ; Bouadma, L. (Hôpital Bichat) ; Bouscambert, M. (Inserm) ; Caralp, M. (Inserm Transfert) ; Cervantes-Gonzalez, M. (REACTing) ; Chair, A. (Hôpital Bichat) ; Coelho, A. (Inserm) ; Couffignal, C. (Hôpital Bichat) ; Couffin-Cadiergues, S. (Pole Recherche Clinique. Inserm) ; D'ortenzio, E. (REACTing) ; da Silveira, C. (Hôpital Bichat) ; Debray, M. P. (Hôpital Bichat) ; Deplanque, D. (Inserm. CHU Lille) ; Descamps, D. (Université de Paris) ; Desvallées, M. (Inserm) ; Diallo, A. (ANRS) ; Diouf, A. (Inserm) ; Dorival, C. (Inserm) ; Dubos, F. (CHU Lille) ; Duval, X. (Centre d'Investigation Clinique. Inserm CIC 1425. Hôpital Bichat Claude Bernard. APHP) ; Eloy, P. (Hôpital Bichat) ; Enouf, V. V. E. (Pasteur Institute) ; Espérou, H. (Pole Recherche Clinique. Inserm) ; Esposito-Farese, M. (Hôpital Bichat) ; Etienne, M. (Rouen - SMIT) ; Ettalhaoui, N. (Hôpital Bichat) ; Gault, N. (Hôpital Bichat) ; Gaymard, A. (Inserm) ; Ghosn, J. (Hôpital Bichat) ; Gigante, T. (FCRIN. INI-CRCT) ; Gorenne, I. (Hôpital Bichat) ; Guedj, J. (Inserm) ; Hoctin, A. (Inserm) ; Hoffmann, I. (Hôpital Bichat) ; Jaafoura, S. (Inserm Sponsor) ; Kafif, O. (Hôpital Bichat Claude Bernard. APHP) ; Kaguelidou, F. (Centre d'Investigation Clinique. Inserm CIC1426. Hôpital Robert Debré) ; Kali, S. (Hôpital Bichat) ; Khalil, A. (Hôpital Bichat) ; Khan, C. (Inserm) ; Laouénan, C. (Hôpital Bichat) ; Laribi, S. (Hôpital Bichat) ; Le, M. (Hôpital Bichat) ; Le Hingrat, Q. (Université de Paris) ; Le Mestre, S. (ANRS) ; Le Nagard, H. (Inserm) ; Lescure, F. X. (Hôpital Bichat) ; Lévy, Y. (Vaccine Research Instiute (VRI)) ; Levy-Marchal, C. (F-CRIN. INI-CRCT) ; Lina, B. (Virpath. Laboratory. International Center of Research in Infectiology. Lyon University. INSERM U1111. CNRS. UMR 5308. ENS. UCBL) ; Lingas, G. (Inserm) ; Lucet, J. C. (IAME. Inserm. UMR 1138. Hôpital Bichat Claude Bernard. APHP) ; Malvy, D. (Service des Maladies Infectieuses et Tropicales. Groupe Pellegrin) ; Mambert, M. (Inserm. UMR 1018) ; Mentré, F. (Hôpital Bichat) ; Mercier, N. (ANRS) ; Meziane, A. (Inserm) ; Mouquet, H. (Pasteur Institute) ; Mullaert, J. (Hôpital Bichat) ; Neant, N. (Inserm) ; Noret, M. (RENARCI) ; Pages, J. (Hôpital Robert Debré) ; Papadopoulos, A. (Inserm Sponsor) ; Paul, C. (ANRS) ; Peiffer-Smadja, N. (Hôpital Bichat) ; Petrov-Sanchez, V. (ANRS) ; Peytavin, G. (Hôpital Bichat) ; Picone, O. (Colombes - Louis Mourier - Gynécologie) ; Puéchal, O. (REACTing) ; Rosa-Calatrava, M. (Inserm) ; Rossignol, B. (FCRIN. INI-CRCT) ; Rossignol, P. (University of Lorraine. Plurithematic Clinical Investigation Centre. Inserm. CIC-P 1433. Inserm U1116. CHRU Nancy Hopitaux de Brabois. F-CRIN. INI-CRCT (Cardiovascular and Renal Clinical Trialists)) ; Roy, C. (Hôpital Bichat) ; Schneider, M. (Hôpital Bichat) ; Semaille, C. (REACTing) ; Mohammed, N. S. (Hôpital Bichat) ; Tagherset, L. (Hôpital Bichat) ; Tardivon, C. (Hôpital Bichat) ; Tellier, M. C. (Hôpital Bichat) ; Téoulé, F. (Inserm) ; Terrier, O. (Inserm) ; Timsit, J. F. (Hôpital Bichat) ; Treoux, T. (Hôpital Bichat) ; Tual, C. (Inserm) ; Tubiana, S. (Centre d'Investigation Clinique. Inserm CIC 1425. Hôpital Bichat Claude Bernard. APHP) ; van der Werf, S. (Université de Paris) ; Vanel, N. (Hôpital la Timone) ; Veislinger, A. (Inserm) ; Visseaux, B. (Université de Paris) ; Wiedemann, A. (Vaccine Research Instiute (VRI)) ; Yazdanpanah, Y. (IAME. Inserm. UMR 1138. Hôpital Bichat Claude Bernard. APHP) ; Abelc, L. (Université de Paris) ; Alcover, A. (Pasteur Institute) ; Aschard, H. (Pasteur Institute) ; Astrom, K. (Lund University) ; Bousso, P. (Pasteur Institute) ; Bruhns, P. (Pasteur Institute) ; Cumano, A. (Pasteur Institute) ; Demangel, C. (Pasteur Institute) ; Deriano, L. (Pasteur Institute) ; Santo, J. D. (Pasteur Institute) ; Dromer, F. (Pasteur Institute) ; Eberl, G. (Pasteur Institute) ; Enninga, J. (Pasteur Institute) ; Fellay, Jacques (Swiss Federal Institute of Technology Lausanne) ; Gomperts-Boneca, I. (Pasteur Institute) ; Hasan, M. (Pasteur Institute) ; Hercberg, S. (Université Paris 13) ; Lantz, O. (Curie Institute) ; Mouquet, H. (Pasteur Institute) ; Patin, E. (Pasteur Institute) ; Pellegrini, S. (Pasteur Institute) ; Pol, S. (Cochin Hospital) ; Rausell, A. (INSERM. UMR 1163. Institut Imagine) ; Rogge, L. (Pasteur Institute) ; Sakuntabhai, A. (Pasteur Institute) ; Schwartz, O. (Pasteur Institute) ; Schwikowski, B. (Pasteur Institute) ; Shorte, S. (Pasteur Institute) ; Tangy, F. (Pasteur Institute) ; Toubert, A. (Hôpital Saint-Louis) ; Touvier, M. (Sorbonne. Paris Nord University) ; Ungeheuer, M. N. (Pasteur Institute) ; Albert, M. L. (In Sitro) ; Duffy, D. (Pasteur Institute) ; Quintana-Murci, L. (Institut Pasteur) ; Alavoine, L. (Centre d'Investigation Clinique. Inserm CIC 1425. Hôpital Bichat Claude Bernard. APHP) ; Amat, K. K. A. (IMEA Fondation Léon M'Ba) ; Behillil, S. (Institut Pasteur) ; Bielicki, J. (University of Basel. Children's Hospital) ; Bruijning, P. (Julius. Center for Health Sciences and Primary Care. University Medical Center Utrecht) ; Burdet, C. (Hôpital Bichat Claude Bernard. APHP) ; Caumes, E. (Hôpital Pitiè Salpétriere. APHP) ; Charpentier, C. (Université de Paris. IAME. INSERM. UMR 1137. AP-HP. University Hospital Bichat Claude Bernard. Virology) ; Coignard, B. (Santé Publique France) ; Costa, Y. (Centre d'Investigation Clinique. Inserm CIC 1425. Hôpital Bichat Claude Bernard. APHP) ; Couffin-Cadiergues, S. (Pole Recherche Clinique. Inserm) ; Damond, F. (Université de Paris) ; Dechanet, A. (Hôpital Bichat Claude Bernard. APHP) ; Delmas, C. (Pole Recherche Clinique. Inserm) ; Descamps, D. (Université de Paris) ; Duval, X. (Centre d'Investigation Clinique. Inserm CIC 1425. Hôpital Bichat Claude Bernard. APHP) ; Ecobichon, J. L. (Centre d'Investigation Clinique. Inserm CIC 1425. Hôpital Bichat Claude Bernard. APHP) ; Enouf, V. (Université de Paris) ; Espérou, H. (Pole Recherche Clinique. Inserm) ; Frezouls, W. (Centre d'Investigation Clinique. Inserm CIC 1425. Hôpital Bichat Claude Bernard. APHP) ; Houhou, N. (Hôpital Bichat Claude Bernard. APHP) ; Ilic-Habensus, E. (Centre d'Investigation Clinique. Inserm CIC 1425. Hôpital Bichat Claude Bernard. APHP) ; Kafif, O. (Hôpital Bichat Claude Bernard. APHP) ; Kikoine, J. (Hôpital Bichat Claude Bernard. APHP) ; Le Hingrat, Q. (Université de Paris) ; Lebeaux, D. (APHP) ; Leclercq, A. (Centre d'Investigation Clinique. Inserm CIC 1425. Hôpital Bichat Claude Bernard. APHP) ; Lehacaut, J. (Centre d'Investigation Clinique. Inserm CIC 1425. Hôpital Bichat Claude Bernard. APHP) ; Letrou, S. (Centre d'Investigation Clinique. Inserm CIC 1425. Hôpital Bichat Claude Bernard. APHP) ; Lina, B. (Virpath. Laboratory. International Center of Research in Infectiology. Lyon University. INSERM U1111. CNRS. UMR 5308. ENS. UCBL) ; Lucet, J. C. (IAME. Inserm. UMR 1138. Hôpital Bichat Claude Bernard. APHP) ; Malvy, D. (Service des Maladies Infectieuses et Tropicales. Groupe Pellegrin) ; Manchon, P. (Hôpital Bichat Claude Bernard. APHP) ; Mandic, M. (Centre d'Investigation Clinique. Inserm CIC 1425. Hôpital Bichat Claude Bernard. APHP) ; Meghadecha, M. (Hôpital Hotel Dieu. APHP) ; Motiejunaite, J. (Service des Explorations Fonctionnelles. Hôpital Bichat - Claude Bernard. APHP) ; Nouroudine, M. (Centre d'Investigation Clinique. Inserm CIC 1425. Hôpital Bichat Claude Bernard. APHP) ; Piquard, V. (Hôpital Bichat Claude Bernard. APHP) ; Postolache, A. (Hôpital Bichat Claude Bernard. APHP) ; Quintin, C. (Centre d'Investigation Clinique. Inserm CIC 1425. Hôpital Bichat Claude Bernard. APHP) ; Rexach, J. (Centre d'Investigation Clinique. Inserm CIC 1425. Hôpital Bichat Claude Bernard. APHP) ; Roufai, L. (Pole Recherche Clinique. Inserm) ; Terzian, Z. (Hôpital Bichat Claude Bernard. APHP) ; Thy, M. (Center for Clinical Investigation. Assistance Publique-Hôpitaux de Paris. Bichat-Claude Bernard University Hospital) ; Tubiana, S. (Centre d'Investigation Clinique. Inserm CIC 1425. Hôpital Bichat Claude Bernard. APHP) ; van der Werf, S. (Institut Pasteur. UMR. 3569 CNRS. Université de Paris) ; Vignali, V. (Centre d'Investigation Clinique. Inserm CIC 1425. Hôpital Bichat Claude Bernard. APHP) ; Visseaux, B. (Université de Paris. IAME. INSERM. UMR 1137. AP-HP. University Hospital Bichat Claude Bernard. Virology) ; Yazdanpanah, Y. (IAME. Inserm. UMR 1138. Hôpital Bichat Claude Bernard. APHP) ; van Agtmael, M. (Amsterdam UMC. University Medical Center) ; Algera, A. G. (Amsterdam UMC. University Medical Center) ; van Baarle, F. (Amsterdam UMC. University Medical Center) ; Bax, D. (Amsterdam UMC. University Medical Center) ; Beudel, M. (Amsterdam UMC. University Medical Center) ; Bogaard, H. J. (Amsterdam UMC. University Medical Center) ; Bomers, M. (Amsterdam UMC. University Medical Center) ; Bos, Lieuwe D. (Amsterdam UMC. University Medical Center) ; Botta, M. (Amsterdam UMC. University Medical Center) ; de Brabander, J. (Amsterdam UMC. University Medical Center) ; Bree, G. (Amsterdam UMC. University Medical Center) ; Brouwer, M. C. (Amsterdam UMC. University Medical Center) ; de Bruin, S. (Amsterdam UMC. University Medical Center) ; Bugiani, M. (Amsterdam UMC. University Medical Center) ; Bulle, E. (Amsterdam UMC. University Medical Center) ; Chouchane, O. (Amsterdam UMC. University Medical Center) ; Cloherty, A. (Amsterdam UMC. University Medical Center) ; Elbers, P. (Amsterdam UMC. University Medical Center) ; Fleuren, L. (Amsterdam UMC. University Medical Center) ; Geerlings, S. (Amsterdam UMC. University Medical Center) ; Geerts, B. (Amsterdam UMC. University Medical Center) ; Geijtenbeek, T. (Amsterdam UMC. University Medical Center) ; Girbes, A. (Amsterdam UMC. University Medical Center) ; Goorhuis, B. (Amsterdam UMC. University Medical Center) ; Grobusch, M. P. (Amsterdam UMC. University Medical Center) ; Hafkamp, F. (Amsterdam UMC. University Medical Center) ; Hagens, L. (Amsterdam UMC. University Medical Center) ; Hamann, J. (Amsterdam UMC. University Medical Center) ; Harris, V. (Amsterdam UMC. University Medical Center) ; Hemke, R. (Amsterdam UMC. University Medical Center) ; Hermans, S. M. (Amsterdam UMC. University Medical Center) ; Heunks, L. (Amsterdam UMC. University Medical Center) ; Hollmann, M. W. (Amsterdam UMC. University Medical Center) ; Horn, J. (Amsterdam UMC. University Medical Center) ; Hovius, J. W. (Amsterdam UMC. University Medical Center) ; de Jong, M. D. (Amsterdam UMC. University Medical Center) ; Koning, R. (Amsterdam UMC. University Medical Center) ; van Mourik, N. (Amsterdam UMC. University Medical Center) ; Nellen, J. (Amsterdam UMC. University Medical Center) ; Paulus, F. (Amsterdam UMC. University Medical Center) ; Peters, E. (Amsterdam UMC. University Medical Center) ; van der Poll, T. (Amsterdam UMC. University Medical Center) ; Preckel, B. (Amsterdam UMC. University Medical Center) ; Prins, J. M. (Amsterdam UMC. University Medical Center) ; Raasveld, J. (Amsterdam UMC. University Medical Center) ; Reijnders, T. (Amsterdam UMC. University Medical Center) ; Schinkel, M. (Amsterdam UMC. University Medical Center) ; Schultz, M. J. (Amsterdam UMC. University Medical Center) ; Schuurman, A. (Amsterdam UMC. University Medical Center) ; Sigaloff, K. (Amsterdam UMC. University Medical Center) ; Smit, M. (Amsterdam UMC. University Medical Center) ; Stijnis, C. S. (Amsterdam UMC. University Medical Center) ; Stilma, Willemke (Amsterdam UMC. University Medical Center) ; Teunissen, C. (Amsterdam UMC. University Medical Center) ; Thoral, P. (Amsterdam UMC. University Medical Center) ; Tsonas, A. (Amsterdam UMC. University Medical Center) ; van der Valk, M. (Amsterdam UMC. University Medical Center) ; Veelo, D. (Amsterdam UMC. University Medical Center) ; Vlaar, A. P. J. (Amsterdam UMC. University Medical Center) ; de Vries, H. (Amsterdam UMC. University Medical Center) ; van Vugt, M. (Amsterdam UMC. University Medical Center) ; Joost Wiersinga, W. (Amsterdam UMC. University Medical Center) ; Wouters, D. (Amsterdam UMC. University Medical Center) ; Zwinderman, A. H. (Amsterdam UMC. University Medical Center) ; van de Beek, D. (Amsterdam UMC. University Medical Center) ; Abelb, L. (INSERM U1163. University of Paris. Imagine Institute) ; Iuti, F. (San Raffaele Telethon Institute for Gene Therapy. IRCCS Ospedale San Raffaele) ; Muhsen, S. A. (King Saud University) ; Al-Mulla, F. (Dasman Diabetes Institute. Department of Genetics and Bioinformatics) ; Anderson, M. S. (University of California. San Francisco) ; Arias, A. A. (Universidad de Antioquia. Group of Primary Immunodeficiencies) ; Feldman, H. B. (Genetics Institute. Tel Aviv Sourasky Medical Center. Sackler Faculty of Medicine. Tel Aviv University) ; Bogunovic, D. (Icahn School of Medicine) ; Bolze, A. (Helix) ; Bondarenko, A. (Shupyk National Medical Academy for Postgraduate Education) ; Bousfiha, A. A. (Clinical Immunology Unit. Pediatric Infectious Disease Department. Faculty of Medicine and Pharmacy. Averroes University Hospital. LICIA Laboratoire d'immunologie Clinique d'inflammation et d'allergie. Hassann Ii University) ; Brodin, P. (Karolinska Institutet (Estocolm, Suècia)) ; Bryceson, Y. (Karolinska Institutet (Estocolm, Suècia)) ; Bustamante, C. D. (Stanford University) ; Butte, M. (University of California) ; Chakravorty, S. (Department of Pediatrics. Children's Healthcare of Atlanta. Emory University) ; Christodoulou, J. (Murdoch Children's Research Institute) ; Cirulli, E. (Helix) ; Condino-Neto, A. (University of São Paulo) ; Cooper, M. A. (Washington University School of Medicine) ; Dalgard, C. L. (American Genome Center. Uniformed Services University of the Health Sciences) ; DeRisi, J. L. (University of California San Francisco. Chan Zuckerberg Biohub) ; Desai, M. (Bai Jerbai Wadia Hospital for Children) ; Drolet, B. A. (School of Medicine and Public Health. University of Wisconsin) ; Espinosa, S. (Instituto Nacional de Pediatria. (National Institute of Pediatrics)) ; Fellay, Jacques (Swiss Federal Institute of Technology Lausanne) ; Flores, Carlos (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife)) ; Franco, J. L. (University of Antioquia) ; Gregersen, P. K. (Feinstein Institute for Medical Research. Northwell Health USA) ; Haerynck, F. (Department of Paediatric Immunology and Pulmonology. Centre for Primary Immunodeficiency Ghent (CPIG). PID Research Laboratory. Jeffrey Modell Diagnosis and Research Centre. Ghent University Hospital) ; Hagin, D. (Genetics Institute Tel Aviv Sourasky Medical Center) ; Halwani, R. (Sharjah Institute of Medical Research. College of Medicine. University of Sharjah) ; Heath, J. (Institute for Systems Biology) ; Henrickson, S. E. (Children's Hospital of Philadelphia (Pennsilvània)) ; Hsieh, E. (Anschutz Medical Campus) ; Imai, K. (Riken) ; Itan, Y. (Icahn School of Medicine) ; Karamitros, T. (Hellenic Pasteur Institute) ; Kisanda, K. (University of Tartu) ; Ku, C. L. (Chang Gung University) ; Lau, Y. L. (University of Hong Kong) ; Ling, Y. (Shanghai Public Health Clinical Center. Fudan University) ; Lucas, C. L. (Yale School of Medicine) ; Maniatis, T. (New York Genome Center) ; Mansouri, D. (Shahid Beheshti University of Medical Sciences) ; Marodi, L. (Semmelweis University Budapest) ; Milner, J. D. (Columbia University Medical Center) ; Mironska, K. (University Clinic for Children's Diseases) ; Morio, T. (Tokyo Medical & Dental University Hospital) ; Notarangeloa, L. D. (National Institute of Allergy and Infectious Diseases (Bethesda, Estats Units d'Amèrica)) ; Novelli, G. (Department of Biomedicine and Prevention. University of Rome "Tor Vergata) ; Novelli, A. (Bambino Gesù Children's Hospital) ; O'Farrelly, C. (Trinity College) ; Okada, S. (Hiroshima University) ; Ozcelik, T. (Bilkent University) ; de Diego, R. P. (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ; Planas, A. M. (IIBB-CSIC. IDIBAPS) ; Prando, C. (Faculdades Pequeno Príncipe. Instituto de Pesquisa Pelé Pequeno Príncipe) ; Pujol, Aurora (Institut d'Investigació Biomèdica de Bellvitge) ; Quintana-Murci, L. (Institut Pasteur. (CNRS UMR 2000). Collège de France) ; Renia, L. (Infectious Diseases Horizontal Technology Center. Singapore Immunology Network. Agency for Science Technology (A*STAR)) ; Renieri, A. (Genetica Medica. Azienda Ospedaliero-Universitaria Senese. GEN-COVID Multicenter Study) ; Rodríguez-Gallego, C. (Hos-pital Universitario de Gran Canaria Dr Negrín. Canarian Health System) ; Sancho-Shimizu, V. (Imperial College London) ; Sankaran, V. (Boston Children's Hospital (Boston, Estats Units d'Amèrica)) ; Barrett, K. S. (Helix) ; Shahrooei, M. (Saeed Pathobiology and Genetic Laboratory) ; Snow, A. (Uniformed Services University of the Health Sciences (USUHS)) ; Soler-Palacín, P. (Hospital Universitari Vall d'Hebron) ; Spaan, A. N. (University Medical Center Utrecht) ; Turvey, S. (University of British Columbia) ; Uddin, F. (Holy Family Red Crescent Medical College. Centre for Precision Therapeutics. NeuroGen Children's Healthcare Genetics and Genomic Medicine Centre. NeuroGen Children's Healthcare) ; Uddin, M. J. (Centre for Applied Genomics. Department of Genetics and Genome Biology. Hospital for Sick Children) ; van de Beek, D. (Amsterdam UMC. University Medical Center) ; Vazquez, S. E. (University of California. San Francisco) ; Vinh, D. C. (McGill University Health Centre) ; von Bernuth, H. (Bern University Hospital) ; Washington, N. (Helix) ; Zawadzki, P. (A. Mickiewicz University. Molecular Biophysics Division) ; Sua, H. C. (National Institute of Allergy and Infectious Diseases (Bethesda, Estats Units d'Amèrica)) ; Casanovaa, J. L. (Rockefeller University. Howard Hughes Medical Institute. Necker Hospital) ; Rosen, L. B. (National Institute of Allergy and Infectious Diseases (Maryland, Estats Units d'Amèrica)) ; Universitat Autònoma de Barcelona
Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-w (IFN-w) (13 patients), against the 13 types of IFN-a (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. [...]
2020 - 10.1126/science.abd4585
Science, Vol. 370 Núm. 6515 (september 2020) , p. eabd4585  
3.
17 p, 2.5 MB Dissemination of Mycobacterium tuberculosis is associated to a SIGLEC1 null variant that limits antigen exchange via trafficking extracellular vesicles / Benet, Susana (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Gálvez, Cristina (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Drobniewski, Francis (Imperial College) ; Kontsevaya, Irina (N.V. Postnikov Samara Region Clinical Tuberculosis Dispensary) ; Arias, Lilibeth (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Monguió-Tortajada, Marta (Universitat Autònoma de Barcelona) ; Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Urrea, Víctor (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Ong, Ruo-Yan (University of Dundee) ; Luquín Fernández, M. (Marina) (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Dupont, Maeva (International associated laboratory (LIA) CNRS "IM-TB/HIV" (1167)) ; Chojnacki, Jakub (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Dalmau, Judith (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Cardona, Paula (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Neyrolles, Olivier (International associated laboratory (LIA) CNRS "IM-TB/HIV" (1167)) ; Lugo-Villarino, Geanncarlo (International associated laboratory (LIA) CNRS "IM-TB/HIV" (1167)) ; Vérollet, Christel (International associated laboratory (LIA) CNRS "IM-TB/HIV" (1167)) ; Julián Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Furrer, Hansjakob (University of Bern) ; Günthard, Huldrych F. (University of Zurich) ; Crocker, Paul R. (University of Dundee) ; Tapia Melendo, Gustavo (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Borràs, Francesc E. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Fellay, Jacques (Lausanne University Hospital) ; McLaren, Paul J. (University of Manitoba) ; Telenti, Amalio (The Scripps Research Institute) ; Cardona, Pere-Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Pérez-Álvarez, Núria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Vilaplana, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Izquierdo Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
The identification of individuals with null alleles enables studying how the loss of gene function affects infection. We previously described a non-functional variant in SIGLEC1, which encodes the myeloid-cell receptor Siglec-1/CD169 implicated in HIV-1 cell-to-cell transmission. [...]
2021 - 10.1002/jev2.12046
Journal of extracellular vesicles, Vol. 10 (january 2021)  
4.
14 p, 2.0 MB Differential Immunodominance Hierarchy of CD8 + T-Cell Responses in HLA-B*27:05- and -B*27:02-Mediated Control of HIV-1 Infection / Adland, Emily ; Hill, Matilda ; Lavandier, Nora ; Csala, Anna ; Edwards, Anne ; Chen, Fabian ; Radkowski, Marek ; Kowalska, Justyna D. ; Paraskevis, Dimitrios ; Hatzakis, Angelos ; Valenzuela-Ponce, Humberto ; Pfafferott, Katja ; Williams, Ian ; Pellegrino, Pierre ; Borrow, Persephone ; Mori, Masahiko ; Rockstroh, Jürgen ; Prado, Julia G. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Dalmau, Judith (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Martinez-Picado, Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Tudor-Williams, Gareth ; Frater, John ; Stryhn, Anette ; Buus, Soren ; Teran, Gustavo Reyes ; Mallal, Simon ; John, Mina ; Buchbinder, Susan ; Kirk, Gregory ; Martin, Jeffrey ; Michael, Nelson ; Fellay, Jacques ; Deeks, Steve ; Walker, Bruce ; Avila-Rios, Santiago ; Cole, David ; Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Carrington, Mary ; Goulder, Philip ; Universitat Autònoma de Barcelona
The well-characterized association between HLA-B*27:05 and protection against HIV disease progression has been linked to immunodominant HLA-B*27:05-restricted CD8 + T-cell responses toward the conserved Gag KK10 (residues 263 to 272) and polymerase (Pol) KY9 (residues 901 to 909) epitopes. [...]
2018 - 10.1128/JVI.01685-17
Journal of Virology, Vol. 92 (january 2018)  
5.
7 p, 617.5 KB Identification of Siglec-1 null individuals infected with HIV-1 / Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; McLaren, Paul J. (National HIV and Retrovirology Laboratory (Winnipeg, Canadà)) ; Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Martin, Maureen P. (Frederick National Laboratory for Cancer Research (Maryland, Estats Units d'Amèrica)) ; Benet, Susana (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Rotger, Margalida (University of Lausanne (Suïssa)) ; Dalmau, Judith (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Ouchi, Dan (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Wolinsky, Steven M. (Northwestern University Feinberg School of Medicine (Chicago, Estats Units d'Amèrica)) ; Penugonda, Sudhir (Northwestern University Feinberg School of Medicine (Chicago, Estats Units d'Amèrica)) ; Günthard, Huldrych F. (University Hospital Zurich (Suïssa)) ; Fellay, Jacques (École Polytechnique Fédérale de Lausanne (Suïssa)) ; Carrington, Mary (Frederick National Laboratory for Cancer Research (Maryland, Estats Units d'Amèrica)) ; Izquierdo Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Telenti, Amalio (J. Craig Venter Institute (La Jolla, Estats Units d'Amèrica))
Siglec-1/CD169 is a myeloid-cell surface receptor critical for HIV-1 capture and infection of bystander target cells. To dissect the role of SIGLEC1 in natura, we scan a large population genetic database and identify a loss-of-function variant (Glu88Ter) that is found in ∼1% of healthy people. [...]
2016 - 10.1038/ncomms12412
Nature communications, Vol. 7 Núm. 12412 (August 2016)  

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