Resultats globals: 17 registres trobats en 0.02 segons.
Articles, 15 registres trobats
Documents de recerca, 2 registres trobats
Articles 15 registres trobats  1 - 10següent  anar al registre:
1.
21 p, 2.1 MB Pharmacogenetic studies with oral anticoagulants. Genome-wide association studies in vitamin K antagonist and direct oral anticoagulants / Cullell, Natalia (Stroke Pharmacogenomics and Genetics, Fundació Docència i Recerca Mútua Terrassa, Hospital Universitari Mútua de Terrassa, Terrassa, Barcelona, Spain) ; Carrera, Caty (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Muiño, Elena (Stroke Pharmacogenomics and Genetics, Fundació Docència i Recerca Mútua Terrassa, Hospital Universitari Mútua de Terrassa, Terrassa, Barcelona, Spain) ; Torres, Nuria (Stroke Pharmacogenomics and Genetics, Fundació Docència i Recerca Mútua Terrassa, Hospital Universitari Mútua de Terrassa, Terrassa, Barcelona, Spain) ; Krupinski, Jerzy (School of Healthcare Science, Manchester Metropolitan University, Manchester, United Kingdom) ; Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ; Universitat Autònoma de Barcelona
Oral anticoagulants (OAs) are the recommended drugs to prevent cardiovascular events and recurrence in patients with atrial fibrillation (AF) and cardioembolic stroke. We conducted a literature search to review the current state of OAs pharmacogenomics, focusing on Genome Wide Association Studies (GWAs) in patients treated with vitamin K antagonists (VKAs) and direct oral anticoagulants (DOACs). [...]
2018 - 10.18632/oncotarget.25579
Oncotarget, Vol. 9 (june 2018) , p. 29238-29258  
2.
8 p, 1.6 MB DNA methylation of MMPs and TIMPs in atherothrombosis process in carotid plaques and blood tissues / Gallego-Fabrega, Cristina (Institut d'Investigació Biomèdica Sant Pau) ; Cullell, Natalia (Institut d'Investigació Biomèdica Sant Pau) ; Soriano-Tárraga, Carolina (Institut Hospital del Mar d'Investigacions Mèdiques) ; Carrera, Caty (Institut d'Investigació Biomèdica Sant Pau) ; Torres-Aguila, Nuria P. (Institut d'Investigació Biomèdica Sant Pau) ; Muiño, Elena (Institut d'Investigació Biomèdica Sant Pau) ; Cárcel-Márquez, Jara (Institut d'Investigació Biomèdica Sant Pau) ; de Moura, Manuel Castro (Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Spain) ; Fernández-Sanlés, Alba (Cardiovascular Epidemiology and Genetics Research Group, Hospital del Mar Medical Research Institute, Universitat Pompeu Fabra, Barcelona, Spain) ; Esteller, Manel (Institucio Catalana de Recerca i Estudis Avançats, Barcelona, Spain) ; Elosua, Roberto (Cardiovascular Epidemiology and Genetics Research Group, Hospital del Mar Medical Research Institute, Universitat Pompeu Fabra, Barcelona, Spain) ; Jiménez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ; Roquer, Jaume (Institut Hospital del Mar d'Investigacions Mèdiques) ; Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Krupinski, Jerzy (* These authors contributed equally to this work) ; Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ; Universitat Autònoma de Barcelona
Background and Purpose: Polymorphisms and serum levels of Matrix Metalloproteinases (MMP) and Tissue Inhibitor of Metalloproteinases (TIMP) have been studied with regard to atheromatous plaques and ischemic stroke, while no studies of DNA methylation (DNAm) patterns of MMP or TIMP have been performed to that end. [...]
2020 - 10.18632/oncotarget.27469
Oncotarget, Vol. 11 (march 2020) , p. 905-912  
3.
14 p, 236.7 KB Clinical Variables and Genetic Risk Factors Associated with the Acute Outcome of Ischemic Stroke : A Systematic Review / Torres-Aguila, Nuria P (Institut d'Investigació Biomèdica Sant Pau) ; Carrera, Caty (Institut d'Investigació Biomèdica Sant Pau) ; Muiño, Elena (Institut d'Investigació Biomèdica Sant Pau) ; Cullell, Natalia (Stroke Pharmacogenomics and Genetics Laboratory, Mutua Terrasa Foundation of Teaching and Research, Mutua Terrassa Hospital, Terrassa) ; Cárcel-Márquez, Jara (Institut d'Investigació Biomèdica Sant Pau) ; Gallego-Fabrega, Cristina (Institut d'Investigació Biomèdica Sant Pau) ; González-Sánchez, Jonathan (Institut d'Investigació Biomèdica Sant Pau) ; Bustamante, Alejandro (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Delgado, Pilar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Ibañez, Laura (Department of Psychiatry, Washington University School of Medicine, St. Louis, MO) ; Heitsch, Laura (Department of Neurology, Washington University School of Medicine, St. Louis, MO) ; Krupinski, Jerzy (Health Care Science Department, The Manchester Metropolitan University of All Saints, Manchester) ; Montaner, Joan (Department of Neurology, Virgin Rocío and Macarena Hospitals, Institute of Biomedicine of Seville (IBiS), Seville) ; Martí-Fàbregas, Joan (Institut d'Investigació Biomèdica Sant Pau) ; Cruchaga, Carlos (Department of Psychiatry, Washington University School of Medicine, St. Louis, MO) ; Lee, Jin-Moo (Department of Neurology, Washington University School of Medicine, St. Louis, MO) ; Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ; Universitat Autònoma de Barcelona
Stroke is a complex disease and one of the main causes of morbidity and mortality among the adult population. A huge variety of factors is known to influence patient outcome, including demographic variables, comorbidities or genetics. [...]
2019 - 10.5853/jos.2019.01522
Journal of Stroke, Vol. 21 (september 2019) , p. 276-289  
4.
Association of Apolipoprotein e with Intracerebral Hemorrhage Risk by Race/Ethnicity : A Meta-analysis / Marini, S. (Massachusetts General Hospital) ; Crawford, K. (Massachusetts General Hospital) ; Morotti, A. (Fondazione Mondino IRCCS, Pavia) ; Lee, M.J. (Massachusetts General Hospital) ; Pezzini, A. (Università degli Studi di Brescia) ; Moomaw, C.J. (University of Cincinnati) ; Flaherty, M.L. (University of Cincinnati) ; Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Roquer Gonzalez, Jaume (Institut Hospital del Mar d'Investigacions Mèdiques) ; Jimenez Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ; Giralt Steinhauer, Eva (Institut Hospital del Mar d'Investigacions Mèdiques) ; Elosua, Roberto (Institut Hospital del Mar d'Investigacions Mèdiques) ; Cuadrado Godia, Elisa (Institut Hospital del Mar d'Investigacions Mèdiques) ; Soriano Tarraga, Carolina (Institut Hospital del Mar d'Investigacions Mèdiques) ; Slowik, A. (Jagiellonian University Medical College, Kraków) ; Jagiella, J.M. (Jagiellonian University Medical College, Kraków) ; Pera, J. (Jagiellonian University Medical College, Kraków) ; Urbanik, A. (Jagiellonian University Medical College, Kraków) ; Pichler, A. (Jagiellonian University Medical College, Kraków) ; Hansen, B.M. (Lund University) ; McCauley, J.L. (John P. Hussman Institute for Human Genomics, Miami) ; Tirschwell, D.L. (University of Washington) ; Selim, M. (Beth Israel Deaconess Medical Center, Boston) ; Brown, D.L. (University of Michigan) ; Silliman, S.L. (University of Florida College of Medicine) ; Worrall, B.B. (University of Virginia Health System) ; Meschia, J.F. (Mayo Clinic, Jacksonville, Florida) ; Kidwell, C.S. (University of Arizona) ; Testai, F.D. (University of Illinois) ; Kittner, S.J. (University of Maryland School of Medicine) ; Schmidt, H. (Medical University of Graz) ; Enzinger, C. (Medical University of Graz) ; Deary, I.J. (University of Edinburgh) ; Rannikmae, K. (University of Edinburgh) ; Samarasekera, N. (University of Edinburgh) ; Salman, R.A.S. (University of Edinburgh) ; Sudlow, C.L. (University of Edinburgh) ; Klijn, C.J.M. (UMC Utrecht Brain Center Rudolf Magnus) ; Van Nieuwenhuizen, K.M. (UMC Utrecht Brain Center Rudolf Magnus) ; Fernandez Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ; Delgado Martínez, María Pilar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Norrving, B. (Lund University) ; Lindgren, A. (Lund University) ; Goldstein, J.N. (Massachusetts General Hospital) ; Viswanathan, A. (Massachusetts General Hospital) ; Greenberg, S.M. (Massachusetts General Hospital) ; Falcone, G.J. (Yale University) ; Biffi, A. (Massachusetts General Hospital) ; Langefeld, C.D. (Wake Forest University, Winston-Salem, North Carolina) ; Woo, D. (University of Cincinnati College of Medicine) ; Rosand, J. (Massachusetts General Hospital) ; Anderson, C.D. (Massachusetts General Hospital) ; Universitat Autònoma de Barcelona
Importance: Genetic studies of intracerebral hemorrhage (ICH) have focused mainly on white participants, but genetic risk may vary or could be concealed by differing nongenetic coexposures in nonwhite populations. [...]
2019 - 10.1001/jamaneurol.2018.4519
JAMA Neurology, Vol. 76 Núm. 4 (april 2019) , p. 480-491  
5.
15 p, 517.3 KB GRECOS project (Genotyping Recurrence Risk of Stroke). The use of genetics to predict the vascular recurrence after stroke / Fernández Cadenas, Israel (Hospital Vall d'Hebron. Departament de Neurologia) ; Mendióroz, Maite (Hospital Vall d'Hebron. Departament de Neurologia) ; Giralt, Dolors (Hospital Vall d'Hebron. Departament de Neurologia) ; Nafría, Cristina (Hospital Vall d'Hebron. Departament de Neurologia) ; Garcia, Elena (Fundació Docència i Recerca Mutua Terrassa) ; Carrera, Caty (Hospital Vall d'Hebron Departament de Neurologia) ; Gallego-Fabrega, Cristina (Fundació Docència i Recerca Mutua Terrassa) ; Domingues-Montanari, Sophie (Hospital Vall d'Hebron. Departament de Neurologia) ; Delgado, Pilar (Hospital Vall d'Hebron. Departament de Neurologia) ; Ribó, Marc (Hospital Vall d'Hebron. Departament de Neurologia) ; Castellanos, Mar (Hospital Universitari Dr. Josep Trueta. Departament de Neurologia) ; Martínez, Sergi (Institut d'Investigació Biomèdica Sant Pau) ; Freijo, Mari Mar (Hospital de Basurto. Departamento de Neurologia) ; Jiménez-Conde, Jordi (Hospital del Mar. Departament de Neurologia) ; Rubiera, Marta (Hospital Vall d'Hebron. Departament de Neurologia) ; Alvarez Sabín, José (Hospital Vall d'Hebron. Departament de Neurologia) ; Molina, Carlos A. (Hospital Vall d'Hebron. Departament de Neurologia) ; Font, Maria Angels (Hospital de Bellvitge. Departament de Neurologia) ; Grau Olivares, Marta (Hospital Universitari Sagrat Cor. Departament de Neurologia) ; Palomeras, Ernest (Hospital de Mataró. Departament de Neurologia) ; Perez de la Ossa, Natalia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Martinez Zabaleta, Maite (Hospital Donostia. Departamento de Neurologia) ; Masjuan, Jaime (Hospital Ramon y Cajal. Departamento de Neurologia) ; Moniche, Francisco (Hospital Universitario Virgen del Rocío. Departamento de Neurologia) ; Canovas, David (Institut d'Investigació i Innovació Parc Taulí. Departament de Neurologia) ; Piñana, Carlos (Hospital Universitario Virgen de las Nieves. Departamento de Neurologia) ; Purroy, Francisco (Hospital Universitari Arnau de Vilanova. Departament de Neurologia) ; Cocho, Dolores (Hospital de Granollers. Departament de Neurologia) ; Navas, Inma (Hospital Mútua de Terrassa. Departament de Neurologia) ; Tejero, Carlos (Hospital Clínico Universitario Lozano Blesa. Departamento de Neurologia) ; Aymerich, Nuria (Hospital de Navarra. Departamento de Neurologia) ; Cullell, Natalia (Fundació Docència i Recerca Mutua Terrassa) ; Muiño, Elena (Fundació Docència i Recerca Mutua Terrassa) ; Serena, Joaquín (Hospital Universitari Dr. Josep Trueta. Departament de Neurologia) ; Rubio, Francisco (Hospital de Bellvitge. Departament de Neurologia) ; Davalos, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Roquer González, Jaume (Hospital del Mar. Departament de Neurologia) ; Arenillas Lara, Juan Francisco (Hospital Clínico Universitario de Valladolid. Departamento de Neurologia) ; Martí Fábregas, Joan (Institut d'Investigació Biomèdica Sant Pau) ; Keene, Keith (Center for Health Disparities. East Carolina University) ; Chen, Wei-Min (Department of Public Health Sciences; Center for Public Health Genomics, University of Virginia) ; Worrall, Bradford (Department of Neurology; Department of Public Health Sciences, University of Virginia) ; Sale, Michele (Center for Public Health Genomics, University of Virginia) ; Arboix, Adrià (Hospital Universitari Sagrat Cor. Departament de Neurologia) ; Krupinski, Jerzy (Hospital Mútua de Terrassa. Departament de Neurologia) ; Montaner, Joan (Hospital Vall d'Hebron. Departament de Neurologia) ; GRECOSstudy group ; Universitat Autònoma de Barcelona
Background and Purpose-Vascular recurrence occurs in 11% of patients during the first year after ischemic stroke (IS) or transient ischemic attack (TIA). Clinical scores do not predict the whole vascular recurrence risk, therefore we aimed to find genetic variants associated with recurrence that might improve the clinical predictive mode is in IS. [...]
2017 - 10.1161/STROKEAHA.116.014322
Stroke, Vol. 48 Núm. 5 (2017) , p. 1147-1153  
6.
5 p, 280.6 KB DNA Methylation in Stroke. Update of Latest Advances / Krupinski, Jerzy (School of Healthcare Science, Manchester Metropolitan University, Manchester, United Kingdom) ; Carrera, Caty (Neurovascular Research Laboratory, Institut de Recerca, Universitat Autònoma de Barcelona, Hospital Vall d'Hebron, Barcelona, Spain) ; Muiño, Elena (Stroke Pharmacogenomics and Genetics, Fundació Docència i Recerca Mutua Terrassa, Hospital Universitari Mútua de Terrassa, Terrassa, Barcelona, Spain) ; Torres, Nuria (Stroke Pharmacogenomics and Genetics, Fundació Docència i Recerca Mutua Terrassa, Hospital Universitari Mútua de Terrassa, Terrassa, Barcelona, Spain) ; Al-Baradie, Raid (Applied Medical Sciences College Majmaah University, Majmaah, Saudi Arabia) ; Cullell, Natalia (Stroke Pharmacogenomics and Genetics, Fundació Docència i Recerca Mutua Terrassa, Hospital Universitari Mútua de Terrassa, Terrassa, Barcelona, Spain) ; Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ; Universitat Autònoma de Barcelona
Epigenetic modifications are hereditable and modifiable factors that do not alter the DNA sequence. These epigenetic factors include DNA methylation, acetylation of histones and non-coding RNAs. Epigenetic factors have mainly been associated with cancer but also with other diseases and conditions such as diabetes or obesity. [...]
2017 - 10.1016/j.csbj.2017.12.001
Computational and Structural Biotechnology Journal, Vol. 16 (december 2017) , p. 1-5  
7.
8 p, 2.3 MB Automated quantification of cerebral edema following hemispheric infarction : Application of a machine-learning algorithm to evaluate CSF shifts on serial head CTs / Chen, Yasheng (Department of Neurology, Washington University, St. Louis, MO 63110, USA) ; Dhar, Rajat (Department of Neurology, Washington University, St. Louis, MO 63110, USA) ; Heitsch, Laura (Emergency Medicine, Washington University, St. Louis, MO 63110, USA) ; Ford, Andria (Department of Neurology, Washington University, St. Louis, MO 63110, USA) ; Fernandez-Cadenas, Israel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Carrera, Caty (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Lin, Weili (Dept. of Radiology, University of North Carolina, Chapel Hill, NC 27599, USA) ; Shen, Dinggang (Department of Brain and Cognitive Engineering, Korea University, Seoul 02841, Republic of Korea) ; An, Hongyu (Radiology, Washington University, St. Louis, MO 63110, USA) ; Lee, Jin-Moo (Biomedical Engineering, Washington University, St. Louis, MO 63110, USA) ; Universitat Autònoma de Barcelona
Although cerebral edema is a major cause of death and deterioration following hemispheric stroke, there remains no validated biomarker that captures the full spectrum of this critical complication. We recently demonstrated that reduction in intracranial cerebrospinal fluid (CSF) volume (∆ CSF) on serial computed tomography (CT) scans provides an accurate measure of cerebral edema severity, which may aid in early triaging of stroke patients for craniectomy. [...]
2016 - 10.1016/j.nicl.2016.09.018
NeuroImage, Vol. 12 (september 2016) , p. 673-680  
8.
11 p, 168.8 KB Genetic variants in CETP increase risk of intracerebral hemorrhage / Anderson, Christopher D. (Program in Medical and Population Genetics, Broad Institute) ; Falcone, Guido J. (Departments of Epidemiology and Biostatistics, Harvard T. H. Chan School of Public Health) ; Phuah, Chia-Ling (Program in Medical and Population Genetics, Broad Institute) ; Radmanesh, Farid (Program in Medical and Population Genetics, Broad Institute) ; Brouwers, H. Bart (Program in Medical and Population Genetics, Broad Institute) ; Battey, Thomas W. K. (Program in Medical and Population Genetics, Broad Institute) ; Biffi, Alessandro (Division of Psychiatry, Department of Psychiatry, MGH) ; Peloso, Gina M. (Program in Medical and Population Genetics, Broad Institute) ; Liu, Dajiang J. (Institute of Personalized Medicine, Penn State College of Medicine) ; Ayres, Alison M. (J. Philip Kistler Stroke Research Center, Department of Neurology, MGH) ; Goldstein, Joshua N. (Department of Emergency Medicine, MGH) ; Viswanathan, Anand (J. Philip Kistler Stroke Research Center, Department of Neurology, MGH) ; Greenberg, Steven M. (J. Philip Kistler Stroke Research Center, Department of Neurology, MGH) ; Selim, Magdy (Beth Israel Deaconess Medical Center) ; Meschia, James F. (Mayo Clinic) ; Brown, Devin L. (University of Michigan Health System) ; Worrall, Bradford B. (University of Virginia Health System) ; Silliman, Scott L. (University of Florida College of Medicine) ; Tirschwell, David L. (University of Washington) ; Flaherty, Matthew L. (University of Cincinnati College of Medicine) ; Kraft, Peter (Departments of Epidemiology and Biostatistics, Harvard T. H. Chan School of Public Health) ; Jagiella, Jeremiasz M. (Jagiellonian University Medical College) ; Schmidt, Helena (Medical University Graz) ; Hansen, Björn M. (Skåne University Hospital) ; Jimenez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ; Giralt Steinhauer, Eva (Institut Hospital del Mar d'Investigacions Mèdiques) ; Elosua Llanos, Roberto (Institut Hospital del Mar d'Investigacions Mèdiques) ; Cuadrado-Godia, Elisa (Institut Hospital del Mar d'Investigacions Mèdiques) ; Soriano Tàrraga, Carolina (Institut Hospital del Mar d'Investigacions Mèdiques) ; van Nieuwenhuizen, Koen M. (University Medical Center Utrecht) ; Klijn, Catharina J. M. (Donders Institute for Brain, Cognition, and Behavior, Radboud University Medical Center) ; Rannikmae, Kristiina (University of Edinburgh) ; Samarasekera, Neshika (University of Edinburgh) ; Salman, Rustam Al-Shahi (University of Edinburgh) ; Sudlow, Catherine L. (University of Edinburgh) ; Deary, Ian J. (University of Edinburgh) ; Morotti, Andrea (Neurology Clinic, University of Brescia) ; Pezzini, Alessandro (Neurology Clinic, University of Brescia) ; Pera, Joanna (Jagiellonian University Medical College) ; Urbanik, Andrzej (Jagiellonian University Medical College) ; Pichler, Alexander (Medical University of Graz) ; Enzinger, Christian (Medical University of Graz) ; Norrving, Bo (Skåne University Hospital) ; Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Fernandez-Cadenas, Israel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Delgado Martínez, Pilar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Roquer González, Jaume (Institut Hospital del Mar d'Investigacions Mèdiques) ; Lindgren, Arne (Skåne University Hospital) ; Slowik, Agnieszka (Jagiellonian University Medical College) ; Schmidt, Reinhold (Medical University of Graz) ; Kidwell, Chelsea S. (University of Arizona) ; Kittner, Steven J. (Baltimore Veterans Administration Medical Center and University of Maryland School of Medicine) ; Waddy, Salina P. (National Institutes of Health) ; Langefeld, Carl D. (Wake Forest University) ; Abecasis, Goncalo (University of Michigan School of Public Health) ; Willer, Cristen J. (University of Michigan Medical School) ; Kathiresan, Sekar (Cardiovascular Disease Prevention Center, MGH) ; Woo, Daniel (University of Cincinnati College of Medicine) ; Rosand, Jonathan (Program in Medical and Population Genetics, Broad Institute) ; Universitat Autònoma de Barcelona. Departament de Neurologia
In observational epidemiologic studies, higher plasma high-density lipoprotein cholesterol (HDL-C) has been associated with increased risk of intracerebral hemorrhage (ICH). DNA sequence variants that decrease cholesteryl ester transfer protein (CETP) gene activity increase plasma HDL-C; as such, medicines that inhibit CETP and raise HDL-C are in clinical development. [...]
2016 - 10.1002/ana.24780
Annals of Neurology, Vol. 80 (october 2016) , p. 730-740  
9.
7 p, 539.4 KB An Inflammatory Polymorphisms Risk Scoring System for the Differentiation of Ischemic Stroke Subtypes / Muiño, Elena (Fundació Docència i Recerca Mútua Terrassa) ; Krupinski, Jurek (Hospital Mutua de Terrassa) ; Carrera, Caty (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Gallego-Fabrega, Cristina (Fundació Docència i Recerca Mútua Terrassa) ; Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Fernández-Cadenas, Israel (Fundació Docència i Recerca Mútua Terrassa) ; Universitat Autònoma de Barcelona
Inflammation has been associated with atherothrombotic stroke and recently with cardioembolic stroke. Different genetic risk factors have been specifically associated with the subtypes of ischemic stroke (cardioembolic, atherothrombotic, and lacunar). [...]
2015 - 10.1155/2015/569714
Mediators of Inflammation, Vol. 2015 (august 2015)  
10.
8 p, 1.0 MB DNA methylation levels are highly correlated between pooled samples and averaged values when analysed using the Infinium HumanMethylation450 BeadChip array / Gallego-Fabrega, Cristina (Universitat Autònoma de Barcelona. Departament de Medicina) ; Carrera, Caty (Hospital Vall d'Hebron. Institut de Recerca) ; Muiño, Elena (Hospital Universitari Mútua de Terrassa) ; Montaner, Joan (Hospital Vall d'Hebron. Institut de Recerca) ; Krupinski, Jurek (School of Healthcare Science, Manchester Metropolitan University) ; Fernandez-Cadenas, Israel (Hospital Universitari Mútua de Terrassa)
DNA methylation is a heritable and stable epigenetic mark implicated in complex human traits. Epigenome-wide association studies (EWAS) using array-based technology are becoming widely used to identify differentially methylated sites associated with complex diseases. [...]
2015 - 10.1186/s13148-015-0097-x
Clinical Epigenetics, Vol. 7 (july 2015)  

Articles : 15 registres trobats   1 - 10següent  anar al registre:
Documents de recerca 2 registres trobats  
1.
366 p, 5.6 MB Genètica aplicada a la clínica neurovascular / Río Espínola, Alberto del, autor ; Fernández Cadenas, Israel, supervisor acadèmic ; Montaner, Joan, supervisor acadèmic ; Álvarez Sabín, J. (José), supervisor acadèmic ; Universitat Autònoma de Barcelona. Departament de Medicina
En aquesta tesi doctoral es descriuen els resultats de l'estudi farmacogenètic Geno-tPA, en el qual es va analitzar el paper de centenars de polimorfismes (SNPs) en la resposta al tractament trombolític de l'ictus isquèmic: recanalització arterial una hora després de la infusió, reoclusión arterial després d'haver recanalitzar, aparició de transformació hemorràgica iatrogènica i mortalitat intrahospitalària. [...]
This thesis describes the results of the Geno-tPA pharmacogenetic study, which analyzed the role of hundreds of polymorphisms (SNPs) in the response to thrombolytic treatmentof ischemic stroke: recanalization one hour after t-PA infusion, arterial reocclusion of the recanalized artery, presence of iatrogenic hemorrhagic transformation and in-hospital mortality. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2011  
2.
207 p, 5.4 MB Identificación y uso de biomarcadores pronósticos en el ictus isquémico / García Berrocoso, Teresa ; Montaner, Joan, dir. ; Fernández Cadenas, Israel, dir. ; Delgado Martínez, Pilar, dir. ; García Dorado, David ; Universitat Autònoma de Barcelona. Departament d'Antropologia Social i Cultural
El ictus es una enfermedad con una elevada morbimortalidad, suponiendo la segunda causa de muerte a nivel mundial y una de las principales causas de discapacidad en el adulto. Aun así, la heterogeneidad entre los pacientes con ictus dificulta anticipar el pronóstico de la enfermedad. [...]
Stroke is a severe disease, being the second cause of death worldwide and one of the main causes of disability. Heterogeneity among stroke patients makes difficult to anticipate the prognosis of the disease. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2014  

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