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Articles, 39 records found
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Articles 39 records found  1 - 10nextend  jump to record:
1.
15 p, 2.4 MB Effectiveness of platelet function analysis-guided aspirin and/or clopidogrel therapy in preventing secondary stroke : A systematic review and meta-analysis / Yan, A.R. (University of Canberra) ; Naunton, M. (University of Canberra) ; Peterson, G.M. (University of Tasmania) ; Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ; Mortazavi, R. (University of Canberra) ; Universitat Autònoma de Barcelona
Antiplatelet medications such as aspirin and clopidogrel are used following thrombotic stroke or transient ischemic attack (TIA) to prevent a recurrent stroke. However, the antiplatelet treatments fail frequently, and patients experience recurrent stroke. [...]
2020 - 10.3390/jcm9123907
Journal of clinical medicine, Vol. 9 Núm. 12 (december 2020) , p. 1-15  
2.
34 p, 7.8 MB Whole-genome sequencing reveals host factors underlying critical COVID-19 / Kousathanas, Athanasios (Genomics England) ; Pairo-Castineira, Erola (MRC Human Genetics Unit. Institute of Genetics and Cancer. University of Edinburgh. Western General Hospital) ; Rawlik, Konrad (Roslin Institute. University of Edinburgh) ; Stuckey, Alexander (Genomics England) ; Odhams, Christopher A. (Genomics England) ; Walker, Susan (Royal Hallamshire Hospital. Northern General Hospital) ; Russell, Clark D. (Centre for Inflammation Research. The Queen's Medical Research Institute. University of Edinburgh) ; Malinauskas, Tomas (Wellcome Centre for Human Genetics. University of Oxford) ; Wu, Yang (Institute for Molecular Bioscience. The University of Queensland) ; Millar, Jonathan E. (Roslin Institute. University of Edinburgh) ; Shen, Xia (Centre for Global Health Research. Usher Institute of Population Health Sciences and Informatics) ; Elliott, Katherine (Wellcome Centre for Human Genetics. University of Oxford) ; Griffiths, Fiona (Roslin Institute. University of Edinburgh) ; Oosthuyzen, Wilna (Roslin Institute. University of Edinburgh) ; Morrice, Kirstie (Edinburgh Clinical Research Facility. Western General Hospital. University of Edinburgh) ; Keating, Sean (Intensive Care Unit. Royal Infirmary of Edinburgh) ; Wang, Bo (Roslin Institute. University of Edinburgh) ; Rhodes, Daniel (Genomics England) ; Klaric, Lucija (MRC Human Genetics Unit. Institute of Genetics and Cancer. University of Edinburgh. Western General Hospital) ; Zechner, Marie (Roslin Institute. University of Edinburgh) ; Parkinson, Nicholas (Roslin Institute. University of Edinburgh) ; Siddiq, Afshan (Genomics England) ; Goddard, Peter (Genomics England) ; Donovan, Sally (Genomics England) ; Maslove, David (Department of Critical Care Medicine. Queen's University and Kingston Health Sciences Centre) ; Nichol, Alistair (Clinical Research Centre. St Vincent's University Hospital. University College Dublin) ; Semple OBE , Malcolm Gracie (Respiratory Medicine and Institute in the Park. Alder Hey Children's Hospital. University of Liverpool) ; Zainy, Tala (Genomics England) ; Maleady-Crowe, Fiona (Genomics England) ; Todd, Linda (Genomics England) ; Salehi, S. (Genomics England) ; Knight, J. (Wellcome Centre for Human Genetics. University of Oxford) ; Elgar, G. (Genomics England) ; Chan, G. (Genomics England) ; Arumugam, P. (Genomics England) ; Patch, C. (Genomics England) ; Rendon, A. (Genomics England) ; Bentley, D. (Illumina Cambridge) ; Kingsley, C. (Illumina Cambridge) ; Kosmicki, J.A. (Regeneron Genetics Center) ; Horowitz, J.E. (Regeneron Genetics Center) ; Baras, A. (Regeneron Genetics Center) ; Abecasis, Goncalo (Regeneron Genetics Center) ; Ferreira, M.A.R. (Regeneron Genetics Center) ; Justice, A. (Geisinger) ; Mirshahi, T. (Geisinger) ; Oetjens, M. (Geisinger) ; Rader, D.J. (Department of Genetics. Perelman School of Medicine. University of Pennsylvania) ; Ritchie, M.D. (Department of Genetics. Perelman School of Medicine. University of Pennsylvania) ; Verma, A. (Department of Genetics. Perelman School of Medicine. University of Pennsylvania) ; Fowler, T.A. (Test and Trace. the Health Security Agency. Department of Health and Social Care) ; Shankar-Hari, M. (Department of Intensive Care Medicine. Guy's and St Thomas' NHS Foundation Trust) ; Summers, Charlotte (Department of Medicine. University of Cambridge) ; Hinds, Charles (William Harvey Research Institute. Barts and the London School of Medicine and Dentistry. Queen Mary University of London) ; Horby, Peter (Centre for Tropical Medicine and Global Health. Nuffield Department of Medicine. University of Oxford) ; McAuley, Danny (Department of Intensive Care Medicine. Royal Victoria Hospital) ; Montgomery, Hugh (UCL Centre for Human Health and Performance) ; Openshaw, Peter (Imperial College Healthcare NHS Trust: London) ; Elliott, P. (Imperial College) ; Walsh, Timothy (Intensive Care Unit. Royal Infirmary of Edinburgh) ; Tenesa, A. (Centre for Global Health Research. Usher Institute of Population Health Sciences and Informatics) ; Fawkes, A. (Edinburgh Clinical Research Facility. Western General Hospital. University of Edinburgh) ; Murphy, L. (University College Dublin. St Vincent's University Hospital) ; Rowan, K. (Intensive Care National Audit and Research Centre) ; Ponting, C.P. (MRC Human Genetics Unit. Institute of Genetics and Cancer. University of Edinburgh. Western General Hospital) ; Vitart, V. (MRC Human Genetics Unit. Institute of Genetics and Cancer. University of Edinburgh. Western General Hospital) ; Wilson, J.F. (Centre for Global Health Research. Usher Institute of Population Health Sciences and Informatics) ; Yang, J. (Westlake Laboratory of Life Sciences and Biomedicine) ; Bretherick, A.D. (MRC Human Genetics Unit. Institute of Genetics and Cancer. University of Edinburgh. Western General Hospital) ; Scott, R.H. (Great Ormond Street Hospital for Children (Londres)) ; Hendry, S.C. (Roslin Institute. University of Edinburgh) ; Moutsianas, L. (Genomics England) ; Law, A. (Roslin Institute. University of Edinburgh) ; Caulfield, M.J. (William Harvey Research Institute. Queen Mary University of London) ; Baillie, John Kenneth (Intensive Care Unit. Royal Infirmary of Edinburgh) ; Begg, Colin (Royal Hospital for Children) ; Ling, L. (Department of Anaesthesia and Intensive Care. The Chinese University of Hong Kong. Prince of Wales Hospital) ; Millar, Johnny (Roslin Institute. University of Edinburgh) ; Pereira, A.C. (Heart Institute. University of São Paulo) ; Aravindan, L. (NIHR Clinical Research Network (CRN). Hammersmith Hospital) ; Armstrong, R. (Roslin Institute. University of Edinburgh) ; Biggs, H. (Cambridge University Hospitals NHS Foundation Trust (Anglaterra)) ; Boz, C. (Roslin Institute. University of Edinburgh) ; Brown, A. (St Mary's Hospital) ; Clark, R. (Edinburgh Clinical Research Facility. Western General Hospital. University of Edinburgh) ; Coutts, A. (Edinburgh Clinical Research Facility. Western General Hospital. University of Edinburgh) ; Coyle, J. (Roslin Institute. University of Edinburgh) ; Cullum, L. (Roslin Institute. University of Edinburgh) ; Das, S. (NIHR Clinical Research Network (CRN). Hammersmith Hospital) ; Day, N. (Roslin Institute. University of Edinburgh) ; Donnelly, L. (Edinburgh Clinical Research Facility. Western General Hospital. University of Edinburgh) ; Duncan, E. (Department of Twin Research and Genetic Epidemiology. King's College London) ; Finernan, P. (Roslin Institute. University of Edinburgh) ; Fourman, M.H. (Roslin Institute. University of Edinburgh) ; Furlong, A. (Cambridge University Hospitals NHS Foundation Trust (Anglaterra)) ; Furniss, J. (Roslin Institute. University of Edinburgh) ; Gallagher, B. (Roslin Institute. University of Edinburgh) ; Gilchrist, T. (Edinburgh Clinical Research Facility. Western General Hospital. University of Edinburgh) ; Golightly, A. (Roslin Institute. University of Edinburgh) ; Hafezi, K. (Edinburgh Clinical Research Facility. Western General Hospital. University of Edinburgh) ; Hamilton, D. (Roslin Institute. University of Edinburgh) ; Hendry, R. (Roslin Institute. University of Edinburgh) ; Law, D. (Roslin Institute. University of Edinburgh) ; Law, R. (Roslin Institute. University of Edinburgh) ; Law, S. (Roslin Institute. University of Edinburgh) ; Lidstone-Scott, R. (Roslin Institute. University of Edinburgh) ; Macgillivray, L. (Edinburgh Clinical Research Facility. Western General Hospital. University of Edinburgh) ; Maclean, A. (Edinburgh Clinical Research Facility. Western General Hospital. University of Edinburgh) ; Mal, H. (Roslin Institute. University of Edinburgh) ; McCafferty, S. (Edinburgh Clinical Research Facility. Western General Hospital. University of Edinburgh) ; McMaster, E. (Roslin Institute. University of Edinburgh) ; Meikle, J. (Roslin Institute. University of Edinburgh) ; Moore, S.C. (NIHR Health Protection Research Unit for Emerging and Zoonotic Infections. Institute of Infection. Veterinary and Ecological Sciences. University of Liverpool) ; Murphy, S. (NIHR Clinical Research Network (CRN). Hammersmith Hospital) ; Hellen, M. (Roslin Institute. University of Edinburgh) ; Zheng, C. (Biostatistics Group. State Key Laboratory of Biocontrol. School of Life Sciences. Sun Yat-sen University) ; Chen, J. (Biostatistics Group. State Key Laboratory of Biocontrol. School of Life Sciences. Sun Yat-sen University) ; Paterson, T. (Roslin Institute. University of Edinburgh) ; Schon, K. (Cambridge University Hospitals NHS Foundation Trust (Anglaterra)) ; Stenhouse, A. (Roslin Institute. University of Edinburgh) ; Das, M. (NIHR Clinical Research Network (CRN). Hammersmith Hospital) ; Swets, M. (Department of Infectious Diseases. Leiden University Medical Center) ; Szoor-McElhinney, H. (Roslin Institute. University of Edinburgh) ; Taneski, F. (Roslin Institute. University of Edinburgh) ; Turtle, L. (NIHR Health Protection Research Unit for Emerging and Zoonotic Infections. Institute of Infection. Veterinary and Ecological Sciences. University of Liverpool) ; Wackett, T. (Roslin Institute. University of Edinburgh) ; Ward, M. (Roslin Institute. University of Edinburgh) ; Weaver, J. (Roslin Institute. University of Edinburgh) ; Wrobel, N. (Edinburgh Clinical Research Facility. Western General Hospital. University of Edinburgh) ; Arbane, G. (Guys and St Thomas' Hospital) ; Bociek, A. (Guys and St Thomas' Hospital) ; Campos, S. (Guys and St Thomas' Hospital) ; Grau, N. (Guys and St Thomas' Hospital) ; Jones, T.O. (Guys and St Thomas' Hospital) ; Lim, R. (Guys and St Thomas' Hospital) ; Marotti, M. (Guys and St Thomas' Hospital) ; Ostermann, M. (Guys and St Thomas' Hospital) ; Whitton, C. (Guys and St Thomas' Hospital) ; Alldis, Z. (Barts Health NHS Trust) ; Astin-Chamberlain, R. (Barts Health NHS Trust) ; Bibi, F. (Barts Health NHS Trust) ; Biddle, J. (Barts Health NHS Trust) ; Blow, S. (Barts Health NHS Trust) ; Bolton, M. (Barts Health NHS Trust) ; Borra, C. (Barts Health NHS Trust) ; Bowles, R. (Barts Health NHS Trust) ; Burton, M. (Barts Health NHS Trust) ; Choudhury, Y. (Barts Health NHS Trust) ; Collier, D. (Rotherham General Hospital) ; Cox, A. (Barts Health NHS Trust) ; Easthope, A. (Barts Health NHS Trust) ; Ebano, P. (Barts Health NHS Trust) ; Fotiadis, S. (Barts Health NHS Trust) ; Gurasashvili, J. (Barts Health NHS Trust) ; Halls, R. (Barts Health NHS Trust) ; Hartridge, P. (Barts Health NHS Trust) ; Kallon, D. (Barts Health NHS Trust) ; Kassam, J. (Barts Health NHS Trust) ; Lancoma-Malcolm, I. (Barts Health NHS Trust) ; Matharu, M. (Barts Health NHS Trust) ; May, P. (Barts Health NHS Trust) ; Mitchelmore, O. (Barts Health NHS Trust) ; Newman, T. (Barts Health NHS Trust) ; Patel, M. (Barts Health NHS Trust) ; Pheby, J. (Barts Health NHS Trust) ; Pinzuti, I. (Barts Health NHS Trust) ; Prime, Z. (Barts Health NHS Trust) ; Prysyazhna, O. (Barts Health NHS Trust) ; Shiel, J. (Barts Health NHS Trust) ; Taylor, M. (University Hospital Wishaw) ; Tierney, C. (Barts Health NHS Trust) ; Wood, S. (Barts Health NHS Trust) ; Zak, A. (Barts Health NHS Trust) ; Zongo, O. (Barts Health NHS Trust) ; Bonner, S. (James Cook University Hospital) ; Hugill, K. (James Cook University Hospital) ; Jones, J. (Princess Royal Hospital. Telford and Royal Shrewsbury Hospital) ; Liggett, S. (James Cook University Hospital) ; Headlam, E. (James Cook University Hospital) ; Bandla, N. (Royal Stoke University Hospital) ; Gellamucho, M. (Royal Stoke University Hospital) ; Davies, M. (Royal Stoke University Hospital) ; Thompson, C. (Royal Stoke University Hospital) ; Abdelrazik, M. (North Middlesex University Hospital NHS Trust) ; Bakthavatsalam, D. (North Middlesex University Hospital NHS Trust) ; Elhassan, M. (North Middlesex University Hospital NHS Trust) ; Ganesan, A. (North Middlesex University Hospital NHS Trust) ; Haldeos, A. (North Middlesex University Hospital NHS Trust) ; Moreno-Cuesta, J. (North Middlesex University Hospital NHS Trust) ; Purohit, D. (North Middlesex University Hospital NHS Trust) ; Vincent, R. (North Middlesex University Hospital NHS Trust) ; Xavier, K. (North Middlesex University Hospital NHS Trust) ; Kumar, R. (Sandwell General Hospital. City Hospital) ; Frater, A. (North Middlesex University Hospital NHS Trust) ; Saleem, M. (North Middlesex University Hospital NHS Trust) ; Carter, D. (North Middlesex University Hospital NHS Trust) ; Jenkins, S. (Poole Hospital) ; Lamond, Z. (North Middlesex University Hospital NHS Trust) ; Wall, A. (North Middlesex University Hospital NHS Trust) ; Fernandez-Roman, J. (The Royal Liverpool University Hospital) ; Hamilton, D.O. (The Royal Liverpool University Hospital) ; Johnson, E. (The Royal Liverpool University Hospital) ; Johnston, B. (The Royal Liverpool University Hospital) ; Martinez, M.L. (The Royal Liverpool University Hospital) ; Mulla, S. (The Royal Liverpool University Hospital) ; Shaw, D. (The Royal Liverpool University Hospital) ; Waite, A.A.C. (The Royal Liverpool University Hospital) ; Waugh, V. (The Royal Liverpool University Hospital) ; Welters, I.D. (The Royal Liverpool University Hospital) ; Williams, K. (The Royal Liverpool University Hospital) ; Cavazza, A. (King's College Hospital NHS Foundation Trust) ; Cockrell, M. (King's College Hospital NHS Foundation Trust) ; Corcoran, E. (King's College Hospital NHS Foundation Trust) ; Depante, M. (King's College Hospital NHS Foundation Trust) ; Finney, C. (King's College Hospital NHS Foundation Trust) ; Jerome, E. (King's College Hospital NHS Foundation Trust) ; McPhail, M. (King's College Hospital NHS Foundation Trust) ; Nayak, M. (King's College Hospital NHS Foundation Trust) ; Noble, H. (King's College Hospital NHS Foundation Trust) ; O'Reilly, K. (King's College Hospital NHS Foundation Trust) ; Pappa, E. (King's College Hospital NHS Foundation Trust) ; Saha, R. (The Princess Alexandra Hospital) ; Saha, S. (King's College Hospital NHS Foundation Trust) ; Smith, J. (Russell's Hall Hospital) ; Knighton, A. (King's College Hospital NHS Foundation Trust) ; Antcliffe, D. (Charing Cross Hospital. St Mary's Hospital. Hammersmith Hospital) ; Banach, D. (Charing Cross Hospital. St Mary's Hospital. Hammersmith Hospital) ; Brett, S. (Charing Cross Hospital. St Mary's Hospital. Hammersmith Hospital) ; Coghlan, P. (Charing Cross Hospital. St Mary's Hospital. Hammersmith Hospital) ; Fernandez, Z. (Charing Cross Hospital. St Mary's Hospital. Hammersmith Hospital) ; Gordon, A. (Charing Cross Hospital. St Mary's Hospital. Hammersmith Hospital) ; Rojo, R. (Charing Cross Hospital. St Mary's Hospital. Hammersmith Hospital) ; Arias, S.S. (Charing Cross Hospital. St Mary's Hospital. Hammersmith Hospital) ; Templeton, M. (Charing Cross Hospital. St Mary's Hospital. Hammersmith Hospital) ; Meredith, M. (Nottingham University Hospital) ; Morris, L. (Nottingham University Hospital) ; Ryan, L. (Nottingham University Hospital) ; Clark, A. (Nottingham University Hospital) ; Sampson, J. (Nottingham University Hospital) ; Peters, C. (Nottingham University Hospital) ; Dent, M. (Nottingham University Hospital) ; Langley, M. (Nottingham University Hospital) ; Ashraf, S. (Nottingham University Hospital) ; Wei, S. (Nottingham University Hospital) ; Andrew, A. (Nottingham University Hospital) ; Bashyal, A. (John Radcliffe Hospital (Oxford, Regne Unit)) ; Davidson, N. (John Radcliffe Hospital (Oxford, Regne Unit)) ; Hutton, P. (John Radcliffe Hospital (Oxford, Regne Unit)) ; McKechnie, S. (John Radcliffe Hospital (Oxford, Regne Unit)) ; Wilson, J. (John Radcliffe Hospital (Oxford, Regne Unit)) ; Baptista, D. (Kingston Hospital) ; Crowe, R. (Kingston Hospital) ; Fernandes, R. (Kingston Hospital) ; Herdman-Grant, R. (Kingston Hospital) ; Joseph, A. (Kingston Hospital) ; O'Connor, D. (Kingston Hospital) ; Allen, M. (Kingston Hospital) ; Loveridge, A. (Kingston Hospital) ; McKenley, I. (Kingston Hospital) ; Morino, E. (Kingston Hospital) ; Naranjo, A. (Kingston Hospital) ; Simms, R. (Kingston Hospital) ; Sollesta, K. (Kingston Hospital) ; Swain, A. (Kingston Hospital) ; Venkatesh, H. (Kingston Hospital) ; Khera, J. (Kingston Hospital) ; Fox, J. (Kingston Hospital) ; Andrew, G. (Royal Infirmary of Edinburgh) ; Barclay, L. (Royal Infirmary of Edinburgh) ; Callaghan, M. (Royal Infirmary of Edinburgh) ; Campbell, R. (Royal Infirmary of Edinburgh) ; Clark, S. (Royal Infirmary of Edinburgh) ; Hope, D. (Royal Infirmary of Edinburgh) ; Marshall, L. (Royal Infirmary of Edinburgh) ; McCulloch, C. (Royal Infirmary of Edinburgh) ; Briton, K. (Royal Infirmary of Edinburgh) ; Singleton, J. (Royal Infirmary of Edinburgh) ; Birch, S. (Royal Infirmary of Edinburgh) ; Brimfield, L. (Queen Alexandra Hospital (Portsmouth, Regne Unit)) ; Daly, Z. (Queen Alexandra Hospital (Portsmouth, Regne Unit)) ; Pogson, D. (Queen Alexandra Hospital (Portsmouth, Regne Unit)) ; Rose, S. (Queen Alexandra Hospital (Portsmouth, Regne Unit)) ; Nown, A. (Queen Alexandra Hospital (Portsmouth, Regne Unit)) ; Battle, C. (Morriston Hospital) ; Brinkworth, E. (Morriston Hospital) ; Harford, R. (Morriston Hospital) ; Murphy, C. (Morriston Hospital) ; Newey, L. (Morriston Hospital) ; Rees, T. (Morriston Hospital) ; Williams, M. (Morriston Hospital) ; Arnold, S. (Morriston Hospital) ; Polgarova, P. (Addenbrookes Hospital (Cambridge, Regne Unit)) ; Stroud, K. (Addenbrookes Hospital (Cambridge, Regne Unit)) ; Meaney, E. (Addenbrookes Hospital (Cambridge, Regne Unit)) ; Jones, M. (Addenbrookes Hospital (Cambridge, Regne Unit)) ; Ng, A. (Addenbrookes Hospital (Cambridge, Regne Unit)) ; Agrawal, S. (Addenbrookes Hospital (Cambridge, Regne Unit)) ; Pathan, N. (Addenbrookes Hospital (Cambridge, Regne Unit)) ; White, D. (Addenbrookes Hospital (Cambridge, Regne Unit)) ; Daubney, E. (Addenbrookes Hospital (Cambridge, Regne Unit)) ; Elston, K. (Addenbrookes Hospital (Cambridge, Regne Unit)) ; Grauslyte, L. (BHRUT (Barking Havering)-Queen's Hospital. King George Hospital) ; Hussain, M. (BHRUT (Barking Havering)-Queen's Hospital. King George Hospital) ; Phull, M. (BHRUT (Barking Havering)-Queen's Hospital. King George Hospital) ; Pogreban, T. (BHRUT (Barking Havering)-Queen's Hospital. King George Hospital) ; Rosaroso, L. (BHRUT (Barking Havering)-Queen's Hospital. King George Hospital) ; Salciute, E. (BHRUT (Barking Havering)-Queen's Hospital. King George Hospital) ; Franke, G. (BHRUT (Barking Havering)-Queen's Hospital. King George Hospital) ; Wong, J. (BHRUT (Barking Havering)-Queen's Hospital. King George Hospital) ; George, A. (BHRUT (Barking Havering)-Queen's Hospital. King George Hospital) ; de Gordoa, L.O.R. (Royal Sussex County Hospital) ; Peasgood, E. (Royal Sussex County Hospital) ; Phillips, C. (Royal Sussex County Hospital) ; Bates, M. (Queen Elizabeth Hospital) ; Dasgin, J. (Queen Elizabeth Hospital) ; Gill, J. (Queen Elizabeth Hospital) ; Nilsson, A. (Queen Elizabeth Hospital) ; Scriven, J. (Queen Elizabeth Hospital) ; Collins, A. (Queen Elizabeth Hospital) ; Khaliq, W. (Queen Elizabeth Hospital) ; Gude, E.T. (Queen Elizabeth Hospital) ; Delgado, C.C. (St George's Hospital) ; Dawson, D. (St George's Hospital) ; Ding, L. (St George's Hospital) ; Durrant, G. (St George's Hospital) ; Ezeobu, O. (St George's Hospital) ; Farnell-Ward, S. (St George's Hospital) ; Harrison, A. (The Alexandra Hospital. Redditch and Worcester Royal Hospital) ; Kanu, R. (St George's Hospital) ; Leaver, S. (St George's Hospital) ; Maccacari, E. (St George's Hospital) ; Manna, S. (St George's Hospital) ; Saluzzio, R.P. (St George's Hospital) ; Queiroz, J. (St George's Hospital) ; Samakomva, T. (St George's Hospital) ; Sicat, C. (St George's Hospital) ; Texeira, J. (St George's Hospital) ; Da Gloria, E.F. (St George's Hospital) ; Lisboa, A. (St George's Hospital) ; Rawlins, J. (St George's Hospital) ; Mathew, J. (St George's Hospital) ; Kinch, A. (St George's Hospital) ; Hurt, W.J. (St George's Hospital) ; Shah, N. (St George's Hospital) ; Clark, V. (St George's Hospital) ; Thanasi, M. (St George's Hospital) ; Yun, N. (St George's Hospital) ; Patel, K. (St George's Hospital) ; Bennett, S. (Stepping Hill Hospital) ; Goodwin, E. (Stepping Hill Hospital) ; Jackson, M. (Stepping Hill Hospital) ; Kent, A. (Stepping Hill Hospital) ; Tibke, C. (Stepping Hill Hospital) ; Woodyatt, W. (Stepping Hill Hospital) ; Zaki, A. (Stepping Hill Hospital) ; Abraheem, A. (Countess of Chester Hospital) ; Bamford, P. (Countess of Chester Hospital) ; Cawley, K. (Countess of Chester Hospital) ; Dunmore, C. (Countess of Chester Hospital) ; Faulkner, M. (Countess of Chester Hospital) ; Girach, R. (Countess of Chester Hospital) ; Jeffrey, H. (Countess of Chester Hospital) ; Jones, R. (Countess of Chester Hospital) ; London, E. (Countess of Chester Hospital) ; Nagra, I. (Countess of Chester Hospital) ; Nasir, F. (Countess of Chester Hospital) ; Sainsbury, H. (Countess of Chester Hospital) ; Smedley, C. (Countess of Chester Hospital) ; Patel, T. (Royal Blackburn Teaching Hospital) ; Smith, M. (Royal Blackburn Teaching Hospital) ; Chukkambotla, S. (Royal Blackburn Teaching Hospital) ; Kazi, A. (Royal Blackburn Teaching Hospital) ; Hartley, J. (Royal Blackburn Teaching Hospital) ; Dykes, J. (Royal Blackburn Teaching Hospital) ; Hijazi, M. (Royal Blackburn Teaching Hospital) ; Keith, S. (Royal Blackburn Teaching Hospital) ; Khan, M. (Royal Blackburn Teaching Hospital) ; Ryan-Smith, J. (Royal Blackburn Teaching Hospital) ; Springle, P. (Royal Blackburn Teaching Hospital) ; Thomas, J. (Royal Blackburn Teaching Hospital) ; Truman, N. (Royal Blackburn Teaching Hospital) ; Saad, S. (Royal Blackburn Teaching Hospital) ; Coleman, D. (Royal Blackburn Teaching Hospital) ; Fine, C. (Royal Blackburn Teaching Hospital) ; Matt, R. (Royal Blackburn Teaching Hospital) ; Gay, B. (Royal Blackburn Teaching Hospital) ; Dalziel, J. (Royal Blackburn Teaching Hospital) ; Ali, S. (Royal Blackburn Teaching Hospital) ; Goodchild, D. (Royal Blackburn Teaching Hospital) ; Harling, R. (Royal Blackburn Teaching Hospital) ; Bhatterjee, R. (Royal Blackburn Teaching Hospital) ; Goddard, W. (Royal Blackburn Teaching Hospital) ; Davison, C. (Royal Blackburn Teaching Hospital) ; Duberly, S. (Royal Blackburn Teaching Hospital) ; Hargreaves, J. (Royal Blackburn Teaching Hospital) ; Bolton, R. (Royal Blackburn Teaching Hospital) ; Davey, M. (The Tunbridge Wells Hospital. Maidstone Hospital) ; Golden, D. (The Tunbridge Wells Hospital. Maidstone Hospital) ; Seaman, R. (The Tunbridge Wells Hospital. Maidstone Hospital) ; Cherian, S. (Royal Gwent Hospital) ; Cutler, S. (Royal Gwent Hospital) ; Heron, A.E. (Royal Gwent Hospital) ; Roynon-Reed, A. (Royal Gwent Hospital) ; Szakmany, T. (Royal Gwent Hospital) ; Williams, G. (Royal Gwent Hospital) ; Richards, O. (Royal Gwent Hospital) ; Cheema, Y. (Royal Gwent Hospital) ; Brooke, H. (Pinderfields General Hospital) ; Buckley, S. (Pinderfields General Hospital) ; Suarez, J.C. (Pinderfields General Hospital) ; Charlesworth, R. (Pinderfields General Hospital) ; Hansson, K. (Pinderfields General Hospital) ; Norris, J. (Pinderfields General Hospital) ; Poole, A. (Pinderfields General Hospital) ; Rose, A. (Pinderfields General Hospital) ; Sandhu, R. (Pinderfields General Hospital) ; Sloan, B. (Pinderfields General Hospital) ; Smithson, E. (Pinderfields General Hospital) ; Thirumaran, M. (Pinderfields General Hospital) ; Wagstaff, V. (Pinderfields General Hospital) ; Metcalfe, A. (Pinderfields General Hospital) ; Brunton, M. (Royal Berkshire NHS Foundation Trust) ; Caterson, J. (Royal Berkshire NHS Foundation Trust) ; Coles, H. (Royal Berkshire NHS Foundation Trust) ; Frise, M. (Royal Berkshire NHS Foundation Trust) ; Rai, S.G. (Royal Berkshire NHS Foundation Trust) ; Jacques, N. (Royal Berkshire NHS Foundation Trust) ; Keating, L. (Royal Berkshire NHS Foundation Trust) ; Tilney, E. (Royal Berkshire NHS Foundation Trust) ; Bartley, S. (Royal Berkshire NHS Foundation Trust) ; Bhuie, P. (Royal Berkshire NHS Foundation Trust) ; Gibson, S. (Broomfield Hospital) ; Lyle, A. (Broomfield Hospital) ; McNeela, F. (Broomfield Hospital) ; Radhakrishnan, J. (Broomfield Hospital) ; Hughes, A. (Broomfield Hospital) ; Yates, B. (Northumbria Healthcare NHS Foundation Trust) ; Reynolds, J. (Northumbria Healthcare NHS Foundation Trust) ; Campbell, H. (Northumbria Healthcare NHS Foundation Trust) ; Thompsom, M. (Northumbria Healthcare NHS Foundation Trust) ; Dodds, S. (Northumbria Healthcare NHS Foundation Trust) ; Duffy, S. (Northumbria Healthcare NHS Foundation Trust) ; Greer, S. (Whiston Hospital) ; Shuker, K. (Whiston Hospital) ; Tridente, A. (Whiston Hospital) ; Khade, R. (Croydon University Hospital) ; Sundar, A. (Croydon University Hospital) ; Tsinaslanidis, G. (Croydon University Hospital) ; Birkinshaw, I. (York Hospital) ; Carter, J. (York Hospital) ; Howard, K. (York Hospital) ; Ingham, J. (York Hospital) ; Joy, R. (York Hospital) ; Pearson, H. (York Hospital) ; Roche, S. (York Hospital) ; Scott, Z. (York Hospital) ; Bancroft, H. (Heartlands Hospital) ; Bellamy, M. (Heartlands Hospital) ; Carmody, M. (Heartlands Hospital) ; Daglish, J. (Heartlands Hospital) ; Moore, F. (Heartlands Hospital) ; Rhodes, J. (Heartlands Hospital) ; Sangombe, M. (Heartlands Hospital) ; Kadiri, S. (Heartlands Hospital) ; Croft, M. (Ashford and St Peter's Hospital) ; White, I. (Ashford and St Peter's Hospital) ; Frost, V. (Ashford and St Peter's Hospital) ; Aquino, M. (Ashford and St Peter's Hospital) ; Jha, R. (Barnet Hospital) ; Krishnamurthy, V. (Barnet Hospital) ; Lim, L. (Barnet Hospital) ; Combes, E. (East Surrey Hospital) ; Joefield, T. (East Surrey Hospital) ; Monnery, S. (East Surrey Hospital) ; Beech, V. (East Surrey Hospital) ; Trotman, S. (East Surrey Hospital) ; Christine Almaden-Boyle, None (Ninewells Hospital) ; Austin, P. (Ninewells Hospital) ; Cabrelli, L. (Ninewells Hospital) ; Cole, S. (Ninewells Hospital) ; Casey, M. (Ninewells Hospital) ; Chapman, S. (Ninewells Hospital) ; Whyte, C. (Ninewells Hospital) ; Baird, Y. (St Richard's Hospital) ; Butler, A. (St Richard's Hospital) ; Chadbourn, I. (St Richard's Hospital) ; Folkes, L. (St Richard's Hospital) ; Fox, H. (St Richard's Hospital) ; Gardner, A. (St Richard's Hospital) ; Gomez, R. (St Richard's Hospital) ; Hobden, G. (St Richard's Hospital) ; Hodgson, L. (St Richard's Hospital) ; King, K. (St Richard's Hospital) ; Margarson, M. (St Richard's Hospital) ; Martindale, T. (St Richard's Hospital) ; Meadows, E. (St Richard's Hospital) ; Raynard, D. (St Richard's Hospital) ; Thirlwall, Y. (St Richard's Hospital) ; Helm, D. (St Richard's Hospital) ; Margalef, J. (St Richard's Hospital) ; Criste, K. (University Hospital Southampton NHS Foundation Trust (Regne Unit)) ; Cusack, R. (University Hospital Southampton NHS Foundation Trust (Regne Unit)) ; Golder, K. (University Hospital Southampton NHS Foundation Trust (Regne Unit)) ; Golding, H. (University Hospital Southampton NHS Foundation Trust (Regne Unit)) ; Jones, O. (University Hospital Southampton NHS Foundation Trust (Regne Unit)) ; Leggett, S. (University Hospital Southampton NHS Foundation Trust (Regne Unit)) ; Male, M. (University Hospital Southampton NHS Foundation Trust (Regne Unit)) ; Marani, M. (University Hospital Southampton NHS Foundation Trust (Regne Unit)) ; Prager, K. (University Hospital Southampton NHS Foundation Trust (Regne Unit)) ; Williams, T. (University Hospital Southampton NHS Foundation Trust (Regne Unit)) ; Roberts, B. (University Hospital Southampton NHS Foundation Trust (Regne Unit)) ; Salmon, K. (University Hospital Southampton NHS Foundation Trust (Regne Unit)) ; Anderson, P. (The Alexandra Hospital. Redditch and Worcester Royal Hospital) ; Archer, K. (The Alexandra Hospital. Redditch and Worcester Royal Hospital) ; Austin, K. (The Alexandra Hospital. Redditch and Worcester Royal Hospital) ; Davis, C. (The Alexandra Hospital. Redditch and Worcester Royal Hospital) ; Durie, A. (The Alexandra Hospital. Redditch and Worcester Royal Hospital) ; Kelsall, O. (The Alexandra Hospital. Redditch and Worcester Royal Hospital) ; Thrush, J. (The Alexandra Hospital. Redditch and Worcester Royal Hospital) ; Vigurs, C. (The Alexandra Hospital. Redditch and Worcester Royal Hospital) ; Wild, L. (The Alexandra Hospital. Redditch and Worcester Royal Hospital) ; Wood, H.L. (The Alexandra Hospital. Redditch and Worcester Royal Hospital) ; Tranter, H. (The Alexandra Hospital. Redditch and Worcester Royal Hospital) ; Harrison, A. (The Alexandra Hospital. Redditch and Worcester Royal Hospital) ; Cowley, N. (The Alexandra Hospital. Redditch and Worcester Royal Hospital) ; McAlindon, M. (The Alexandra Hospital. Redditch and Worcester Royal Hospital) ; Burtenshaw, A. (The Alexandra Hospital. Redditch and Worcester Royal Hospital) ; Digby, S. (The Alexandra Hospital. Redditch and Worcester Royal Hospital) ; Low, E. (The Alexandra Hospital. Redditch and Worcester Royal Hospital) ; Morgan, A. (The Alexandra Hospital. Redditch and Worcester Royal Hospital) ; Cother, N. (The Alexandra Hospital. Redditch and Worcester Royal Hospital) ; Rankin, T. (The Alexandra Hospital. Redditch and Worcester Royal Hospital) ; Clayton, S. (The Alexandra Hospital. Redditch and Worcester Royal Hospital) ; McCurdy, A. (The Alexandra Hospital. Redditch and Worcester Royal Hospital) ; Ahmed, C. (Sandwell General Hospital. City Hospital) ; Baines, B. (Sandwell General Hospital. City Hospital) ; Clamp, S. (Sandwell General Hospital. City Hospital) ; Colley, J. (Sandwell General Hospital. City Hospital) ; Haq, R. (Sandwell General Hospital. City Hospital) ; Hayes, A. (Sandwell General Hospital. City Hospital) ; Hulme, J. (Sandwell General Hospital. City Hospital) ; Hussain, S. (Sandwell General Hospital. City Hospital) ; Joseph, S. (Sandwell General Hospital. City Hospital) ; Kumar, R. (Sandwell General Hospital. City Hospital) ; Maqsood, Z. (Sandwell General Hospital. City Hospital) ; Purewal, M. (Sandwell General Hospital. City Hospital) ; Benham, L. (Blackpool Victoria Hospital) ; Bradshaw, Z. (Blackpool Victoria Hospital) ; Brown, J. (Blackpool Victoria Hospital) ; Caswell, M. (Blackpool Victoria Hospital) ; Cupitt, J. (Blackpool Victoria Hospital) ; Melling, S. (Blackpool Victoria Hospital) ; Preston, S. (Blackpool Victoria Hospital) ; Slawson, N. (Blackpool Victoria Hospital) ; Stoddard, E. (Blackpool Victoria Hospital) ; Warden, S. (Blackpool Victoria Hospital) ; Deacon, B. (Royal Glamorgan Hospital) ; Lynch, C. (Royal Glamorgan Hospital) ; Pothecary, C. (Royal Glamorgan Hospital) ; Roche, L. (Princess of Wales Hospital) ; Howe, G.S. (Royal Glamorgan Hospital) ; Singh, J. (Royal Glamorgan Hospital) ; Turner, K. (Royal Glamorgan Hospital) ; Ellis, H. (Royal Glamorgan Hospital) ; Stroud, N. (Royal Glamorgan Hospital) ; Hunt, J. (North Devon District Hospital) ; Dearden, J. (The Royal Oldham Hospital) ; Dobson, E. (The Royal Oldham Hospital) ; Drummond, A. (The Royal Oldham Hospital) ; Mulcahy, M. (The Royal Oldham Hospital) ; Munt, S. (The Royal Oldham Hospital) ; O'Connor, G. (The Royal Oldham Hospital) ; Philbin, J. (The Royal Oldham Hospital) ; Rishton, C. (The Royal Oldham Hospital) ; Tully, R. (The Royal Oldham Hospital) ; Winnard, S. (The Royal Oldham Hospital) ; Cathcart, S. (Glasgow Royal Infirmary) ; Duffy, K. (Glasgow Royal Infirmary) ; Puxty, A. (Glasgow Royal Infirmary) ; Puxty, K. (Glasgow Royal Infirmary) ; Turner, L. (Glasgow Royal Infirmary) ; Ireland, J. (Glasgow Royal Infirmary) ; Semple, G. (Glasgow Royal Infirmary) ; Long, K. (St James's University Hospital and Leeds General Infirmary) ; Whiteley, S. (St James's University Hospital and Leeds General Infirmary) ; Wilby, E. (St James's University Hospital and Leeds General Infirmary) ; Ogg, B. (St James's University Hospital and Leeds General Infirmary) ; Cowton, A. (Darlington Memorial Hospital) ; Kay, A. (Darlington Memorial Hospital) ; Kent, M. (Darlington Memorial Hospital) ; Potts, K. (Darlington Memorial Hospital) ; Wilkinson, A. (Darlington Memorial Hospital) ; Campbell, S. (Darlington Memorial Hospital) ; Brown, E. (Darlington Memorial Hospital) ; Melville, J. (Fairfield General Hospital) ; Naisbitt, J. (Fairfield General Hospital) ; Joseph, R. (Fairfield General Hospital) ; Lazo, M. (Fairfield General Hospital) ; Walton, O. (Fairfield General Hospital) ; Neal, A. (Fairfield General Hospital) ; Alexander, P. (Wythenshawe Hospital) ; Allen, S. (Wythenshawe Hospital) ; Bradley-Potts, J. (Wythenshawe Hospital) ; Brantwood, C. (Wythenshawe Hospital) ; Egan, J. (Wythenshawe Hospital) ; Felton, T. (Wythenshawe Hospital) ; Padden, G. (Wythenshawe Hospital) ; Ward, L. (Wythenshawe Hospital) ; Moss, S. (Wythenshawe Hospital) ; Glasgow, S. (Wythenshawe Hospital) ; Abel, L. (Royal Alexandra Hospital) ; Brett, M. (Royal Alexandra Hospital) ; Digby, B. (Royal Alexandra Hospital) ; Gemmell, L. (Royal Alexandra Hospital) ; Hornsby, J. (Royal Alexandra Hospital) ; MacGoey, P. (Royal Alexandra Hospital) ; O'Neil, P. (Royal Alexandra Hospital) ; Price, R. (Royal Alexandra Hospital) ; Rodden, N. (Royal Alexandra Hospital) ; Rooney, K. (Royal Alexandra Hospital) ; Sundaram, R. (Royal Alexandra Hospital) ; Thomson, N. (Royal Alexandra Hospital) ; Hopkins, B. (Good Hope Hospital) ; Thrasyvoulou, L. (Good Hope Hospital) ; Willis, H. (Good Hope Hospital) ; Clark, M. (University Hospital of North Tees) ; Coulding, M. (Tameside General Hospital) ; Jude, E. (Tameside General Hospital) ; McCormick, J. (Tameside General Hospital) ; Mercer, O. (Tameside General Hospital) ; Potla, D. (Tameside General Hospital) ; Rehman, H. (Tameside General Hospital) ; Savill, H. (Tameside General Hospital) ; Turner, V. (Tameside General Hospital) ; Downes, C. (Royal Derby Hospital) ; Holding, K. (Royal Derby Hospital) ; Riches, K. (Royal Derby Hospital) ; Hilton, M. (Royal Derby Hospital) ; Hayman, M. (Royal Derby Hospital) ; Subramanian, D. (Royal Derby Hospital) ; Daniel, P. (Royal Derby Hospital) ; Adanini, O. (Medway Maritime Hospital) ; Bhatia, N. (Medway Maritime Hospital) ; Msiska, M. (Medway Maritime Hospital) ; Collins, R. (Medway Maritime Hospital) ; Clement, I. (Royal Victoria Infirmary) ; Patel, B. (Royal Brompton Hospital (Londres)) ; Gulati, A. (Royal Victoria Infirmary) ; Hays, C. (Royal Victoria Infirmary) ; Webster, K. (Royal Victoria Infirmary) ; Hudson, A. (Royal Victoria Infirmary) ; Webster, A. (Royal Victoria Infirmary) ; Stephenson, E. (Royal Victoria Infirmary) ; McCormack, L. (Royal Victoria Infirmary) ; Slater, V. (Royal Victoria Infirmary) ; Nixon, R. (Royal Victoria Infirmary) ; Hanson, H. (Royal Victoria Infirmary) ; Fearby, M. (Royal Victoria Infirmary) ; Kelly, S. (Royal Victoria Infirmary) ; Bridgett, V. (Royal Victoria Infirmary) ; Robinson, P. (Royal Victoria Infirmary) ; Camsooksai, J. (Poole Hospital) ; Humphrey, C. (Poole Hospital) ; Jenkins, S. (Poole Hospital) ; Reschreiter, H. (Poole Hospital) ; Wadams, B. (Poole Hospital) ; Death, Y. (Poole Hospital) ; Bastion, V. (Bedford Hospital) ; Clarke, D. (Bedford Hospital) ; David, B. (Bedford Hospital) ; Kent, H. (Bedford Hospital) ; Lorusso, R. (Bedford Hospital) ; Lubimbi, G. (Bedford Hospital) ; Murdoch, S. (Bedford Hospital) ; Penacerrada, M. (Bedford Hospital) ; Thomas, A. (Ysbyty Gwynedd) ; Valentine, J. (Bedford Hospital) ; Vochin, A. (Bedford Hospital) ; Wulandari, R. (Bedford Hospital) ; Djeugam, B. (Bedford Hospital) ; Bell, G. (Queens Hospital Burton) ; English, K. (Queens Hospital Burton) ; Katary, A. (Queens Hospital Burton) ; Wilcox, L. (Queens Hospital Burton) ; Bruce, M. (North Manchester General Hospital) ; Connolly, K. (North Manchester General Hospital) ; Duncan, T. (North Manchester General Hospital) ; Michael, H.T. (North Manchester General Hospital) ; Lindergard, G. (North Manchester General Hospital) ; Hey, S. (North Manchester General Hospital) ; Fox, C. (North Manchester General Hospital) ; Alfonso, J. (North Manchester General Hospital) ; Durrans, L.J. (North Manchester General Hospital) ; Guerin, J. (North Manchester General Hospital) ; Blackledge, B. (North Manchester General Hospital) ; Harris, J. (North Manchester General Hospital) ; Hruska, M. (North Manchester General Hospital) ; Eltayeb, A. (North Manchester General Hospital) ; Lamb, T. (North Manchester General Hospital) ; Hodgkiss, T. (North Manchester General Hospital) ; Cooper, L. (North Manchester General Hospital) ; Rothwell, J. (North Manchester General Hospital) ; Allan, A. (Aberdeen Royal Infirmary) ; Anderson, F. (Aberdeen Royal Infirmary) ; Kaye, C. (Aberdeen Royal Infirmary) ; Liew, J. (Aberdeen Royal Infirmary) ; Medhora, J. (Aberdeen Royal Infirmary) ; Scott, T. (Aberdeen Royal Infirmary) ; Trumper, E. (Aberdeen Royal Infirmary) ; Botello, A. (Aberdeen Royal Infirmary) ; Lankester, L. (Derriford Hospital) ; Nikitas, N. (Derriford Hospital) ; Wells, C. (Derriford Hospital) ; Stowe, B. (Derriford Hospital) ; Spencer, K. (Derriford Hospital) ; Brandwood, C. (Manchester Royal Infirmary) ; Smith, L. (Manchester Royal Infirmary) ; Birchall, K. (Royal Hallamshire Hospital. Northern General Hospital) ; Kolakaluri, L. (Manchester Royal Infirmary) ; Baines, D. (Manchester Royal Infirmary) ; Sukumaran, A. (Manchester Royal Infirmary) ; Apetri, E. (Salford Royal Hospital) ; Basikolo, C. (Salford Royal Hospital) ; Catlow, L. (Salford Royal Hospital) ; Charles, B. (Salford Royal Hospital) ; Dark, P. (Salford Royal Hospital) ; Doonan, R. (Salford Royal Hospital) ; Harvey, A. (Salford Royal Hospital) ; Horner, D. (Salford Royal Hospital) ; Knowles, K. (Salford Royal Hospital) ; Lee, S. (Salford Royal Hospital) ; Lomas, D. (Salford Royal Hospital) ; Lyons, C. (Salford Royal Hospital) ; Marsden, T. (Salford Royal Hospital) ; McLaughlan, D. (Salford Royal Hospital) ; McMorrow, L. (Salford Royal Hospital) ; Pendlebury, J. (Salford Royal Hospital) ; Perez, J. (Salford Royal Hospital) ; Poulaka, M. (Salford Royal Hospital) ; Proudfoot, N. (Salford Royal Hospital) ; Slaughter, M. (Salford Royal Hospital) ; Slevin, K. (Salford Royal Hospital) ; Thomas, V. (Salford Royal Hospital) ; Walker, D. (Salford Royal Hospital) ; Michael, A. (Salford Royal Hospital) ; Collis, M. (Salford Royal Hospital) ; Cosier, T. (William Harvey Hospital) ; Millen, G. (William Harvey Hospital) ; Richardson, N. (William Harvey Hospital) ; Schumacher, N. (William Harvey Hospital) ; Weston, H. (William Harvey Hospital) ; Rand, J. (William Harvey Hospital) ; Baxter, N. (Queen Elizabeth University Hospital) ; Henderson, S. (Queen Elizabeth University Hospital) ; Kennedy-Hay, S. (Queen Elizabeth University Hospital) ; McParland, C. (Airedale General Hospital) ; Rooney, L. (Queen Elizabeth University Hospital) ; Sim, M. (Queen Elizabeth University Hospital) ; McCreath, G. (Queen Elizabeth University Hospital) ; Akeroyd, L. (Bradford Royal Infirmary) ; Bano, S. (Bradford Royal Infirmary) ; Bromley, M. (Bradford Royal Infirmary) ; Gurr, L. (Bradford Royal Infirmary) ; Lawton, T. (Bradford Royal Infirmary) ; Morgan, J. (Bradford Royal Infirmary) ; Sellick, K. (Bradford Royal Infirmary) ; Warren, D. (Bradford Royal Infirmary) ; Wilkinson, B. (Bradford Royal Infirmary) ; McGowan, J. (Bradford Royal Infirmary) ; Ledgard, C. (Bradford Royal Infirmary) ; Stacey, A. (Bradford Royal Infirmary) ; Pye, K. (Bradford Royal Infirmary) ; Bellwood, R. (Bradford Royal Infirmary) ; Bentley, M. (Bradford Royal Infirmary) ; Bewley, J. (Bristol Royal Infirmary) ; Garland, Z. (Bristol Royal Infirmary) ; Grimmer, L. (Bristol Royal Infirmary) ; Gumbrill, B. (Bristol Royal Infirmary) ; Johnson, R. (Bristol Royal Infirmary) ; Sweet, K. (Bristol Royal Infirmary) ; Webster, D. (Bristol Royal Infirmary) ; Efford, G. (Bristol Royal Infirmary) ; Convery, K. (Norfolk and Norwich University Hospital (NNUH)) ; Fottrell-Gould, D. (Norfolk and Norwich University Hospital (NNUH)) ; Hudig, L. (Norfolk and Norwich University Hospital (NNUH)) ; Keshet-Price, J. (Norfolk and Norwich University Hospital (NNUH)) ; Randell, G. (Norfolk and Norwich University Hospital (NNUH)) ; Stammers, K. (Norfolk and Norwich University Hospital (NNUH)) ; Bokhari, M. (Queen Elizabeth Hospital Gateshead) ; Linnett, V. (Queen Elizabeth Hospital Gateshead) ; Lucas, R. (Queen Elizabeth Hospital Gateshead) ; McCormick, W. (Queen Elizabeth Hospital Gateshead) ; Ritzema, J. (Queen Elizabeth Hospital Gateshead) ; Sanderson, A. (Queen Elizabeth Hospital Gateshead) ; Wild, H. (Queen Elizabeth Hospital Gateshead) ; Rostron, A. (Sunderland Royal Hospital) ; Roy, A. (Sunderland Royal Hospital) ; Woods, L. (Sunderland Royal Hospital) ; Cornell, S. (Sunderland Royal Hospital) ; Wakinshaw, F. (Sunderland Royal Hospital) ; Rogerson, K. (Sunderland Royal Hospital) ; Jarmain, J. (Sunderland Royal Hospital) ; Parker, R. (Aintree University Hospital) ; Reddy, A. (Aintree University Hospital) ; Turner-Bone, I. (Aintree University Hospital) ; Harding, P. (Aintree University Hospital) ; Abernathy, C. (Hull Royal Infirmary) ; Foster, L. (Hull Royal Infirmary) ; Gratrix, A. (Hull Royal Infirmary) ; Martinson, V. (Hull Royal Infirmary) ; Parkinson, P. (Hull Royal Infirmary) ; Stones, E. (Hull Royal Infirmary) ; Carbral-Ortega, L. (Hull Royal Infirmary) ; Bercades, G. (University College Hospital) ; Brealey, D. (University College Hospital) ; Hass, I. (University College Hospital) ; MacCallum, N. (University College Hospital) ; Martir, G. (University College Hospital) ; Raith, E. (University College Hospital) ; Reyes, A. (University College Hospital) ; Smyth, D. (University College Hospital) ; Zitter, L. (Royal Devon and Exeter Hospital) ; Benyon, S. (Royal Devon and Exeter Hospital) ; Marriott, S. (Royal Devon and Exeter Hospital) ; Park, L. (Royal Devon and Exeter Hospital) ; Keenan, S. (Royal Devon and Exeter Hospital) ; Gordon, E. (Royal Devon and Exeter Hospital) ; Quinn, H. (Royal Devon and Exeter Hospital) ; Baines, K. (Royal Devon and Exeter Hospital) ; Cagova, L. (The Royal Papworth Hospital) ; Fofano, A. (The Royal Papworth Hospital) ; Garner, L. (The Royal Papworth Hospital) ; Holcombe, H. (The Royal Papworth Hospital) ; Mepham, S. (The Royal Papworth Hospital) ; Mitchell, A.M. (The Royal Papworth Hospital) ; Mwaura, L. (The Royal Papworth Hospital) ; Praman, K. (The Royal Papworth Hospital) ; Vuylsteke, A. (The Royal Papworth Hospital) ; Zamikula, J. (The Royal Papworth Hospital) ; Purewal, B. (Ipswich Hospital) ; Rivers, V. (Ipswich Hospital) ; Bell, S. (Ipswich Hospital) ; Blakemore, H. (Southmead Hospital) ; Borislavova, B. (Southmead Hospital) ; Faulkner, B. (Southmead Hospital) ; Gendall, E. (Southmead Hospital) ; Goff, E. (Southmead Hospital) ; Hayes, K. (Southmead Hospital) ; Thomas, M. (Southmead Hospital) ; Worner, R. (Southmead Hospital) ; Smith, K. (Southmead Hospital) ; Stephens, D. (Southmead Hospital) ; Mew, L. (Milton Keynes University Hospital) ; Mwaura, E. (Milton Keynes University Hospital) ; Stewart, R. (Milton Keynes University Hospital) ; Williams, F. (Milton Keynes University Hospital) ; Wren, L. (Milton Keynes University Hospital) ; Sutherland, S.B. (Milton Keynes University Hospital) ; Bevan, E. (Royal Hampshire County Hospital) ; Martin, J. (Royal Hampshire County Hospital) ; Trodd, D. (Royal Hampshire County Hospital) ; Watson, G. (Royal Hampshire County Hospital) ; Brown, C.W. (Royal Hampshire County Hospital) ; Akinkugbe, O. (Great Ormond St Hospital. UCL Great Ormond St Institute of Child Health NIHR Biomedical Research Centre) ; Bamford, A. (Great Ormond St Hospital. UCL Great Ormond St Institute of Child Health NIHR Biomedical Research Centre) ; Beech, E. (Great Ormond St Hospital. UCL Great Ormond St Institute of Child Health NIHR Biomedical Research Centre) ; Belfield, H. (Great Ormond St Hospital. UCL Great Ormond St Institute of Child Health NIHR Biomedical Research Centre) ; Bell, M. (Great Ormond St Hospital. UCL Great Ormond St Institute of Child Health NIHR Biomedical Research Centre) ; Davies, C. (Great Ormond St Hospital. UCL Great Ormond St Institute of Child Health NIHR Biomedical Research Centre) ; Jones, G.A.L. (Great Ormond St Hospital. UCL Great Ormond St Institute of Child Health NIHR Biomedical Research Centre) ; McHugh, T. (Great Ormond St Hospital. UCL Great Ormond St Institute of Child Health NIHR Biomedical Research Centre) ; Meghari, H. (Great Ormond St Hospital. UCL Great Ormond St Institute of Child Health NIHR Biomedical Research Centre) ; O'Neill, L. (Great Ormond St Hospital. UCL Great Ormond St Institute of Child Health NIHR Biomedical Research Centre) ; Peters, M.J. (Great Ormond St Hospital. UCL Great Ormond St Institute of Child Health NIHR Biomedical Research Centre) ; Ray, S. (Great Ormond St Hospital. UCL Great Ormond St Institute of Child Health NIHR Biomedical Research Centre) ; Tomas, A.L. (Great Ormond St Hospital. UCL Great Ormond St Institute of Child Health NIHR Biomedical Research Centre) ; Burn, I. (Stoke Mandeville Hospital) ; Hambrook, G. (Stoke Mandeville Hospital) ; Manso, K. (Stoke Mandeville Hospital) ; Penn, R. (Stoke Mandeville Hospital) ; Shanmugasundaram, P. (Stoke Mandeville Hospital) ; Tebbutt, J. (Stoke Mandeville Hospital) ; Thornton, D. (Stoke Mandeville Hospital) ; Cole, J. (Royal Hallamshire Hospital. Northern General Hospital) ; Davies, R. (University Hospital of Wales) ; Duffin, D. (University Hospital of Wales) ; Hill, H. (University Hospital of Wales) ; Player, B. (University Hospital of Wales) ; Thomas, E. (University Hospital of Wales) ; Williams, A. (St John's Hospital Livingston) ; Griffin, D. (Basingstoke and North Hampshire Hospital) ; Muchenje, N. (Basingstoke and North Hampshire Hospital) ; Mupudzi, M. (Basingstoke and North Hampshire Hospital) ; Partridge, R. (Basingstoke and North Hampshire Hospital) ; Conyngham, J.A. (Basingstoke and North Hampshire Hospital) ; Thomas, R. (Basingstoke and North Hampshire Hospital) ; Wright, M. (Basingstoke and North Hampshire Hospital) ; Corral, M.A. (Basingstoke and North Hampshire Hospital) ; Jacob, R. (Arrowe Park Hospital) ; Jones, C. (Arrowe Park Hospital) ; Denmade, C. (Arrowe Park Hospital) ; Beavis, S. (Chesterfield Royal Hospital Foundation Trust) ; Dale, K. (Chesterfield Royal Hospital Foundation Trust) ; Gascoyne, R. (Chesterfield Royal Hospital Foundation Trust) ; Hawes, J. (Chesterfield Royal Hospital Foundation Trust) ; Pritchard, K. (Chesterfield Royal Hospital Foundation Trust) ; Stevenson, L. (Chesterfield Royal Hospital Foundation Trust) ; Whileman, A. (Chesterfield Royal Hospital Foundation Trust) ; Doble, P. (Musgrove Park Hospital) ; Hutter, J. (Musgrove Park Hospital) ; Pawley, C. (Musgrove Park Hospital) ; Shovelton, C. (Musgrove Park Hospital) ; Vaida, M. (Musgrove Park Hospital) ; Butcher, D. (Hinchingbrooke Hospital) ; O'Sullivan, S. (Hinchingbrooke Hospital) ; Butterworth-Cowin, N. (Hinchingbrooke Hospital) ; Ahmad, N. (Royal Hallamshire Hospital. Northern General Hospital) ; Barker, J. (Royal Hallamshire Hospital. Northern General Hospital) ; Bauchmuller, K. (Royal Hallamshire Hospital. Northern General Hospital) ; Bird, S. (Royal Hallamshire Hospital. Northern General Hospital) ; Cawthron, K. (Royal Hallamshire Hospital. Northern General Hospital) ; Harrington, K. (Royal Hallamshire Hospital. Northern General Hospital) ; Jackson, Y. (Royal Hallamshire Hospital. Northern General Hospital) ; Kibutu, F. (Royal Hallamshire Hospital. Northern General Hospital) ; Lenagh, B. (Royal Hallamshire Hospital. Northern General Hospital) ; Masuko, S. (Royal Hallamshire Hospital. Northern General Hospital) ; Mills, G.H. (Royal Hallamshire Hospital. Northern General Hospital) ; Raithatha, A. (Royal Hallamshire Hospital. Northern General Hospital) ; Wiles, M. (Royal Hallamshire Hospital. Northern General Hospital) ; Willson, J. (Royal Hallamshire Hospital. Northern General Hospital) ; Newell, H. (Royal Hallamshire Hospital. Northern General Hospital) ; Lye, A. (Royal Hallamshire Hospital. Northern General Hospital) ; Nwafor, L. (Royal Hallamshire Hospital. Northern General Hospital) ; Jarman, C. (Royal Hallamshire Hospital. Northern General Hospital) ; Rowland-Jones, S. (Royal Hallamshire Hospital. Northern General Hospital) ; Foote, D. (Royal Hallamshire Hospital. Northern General Hospital) ; Cole, J. (Royal Hallamshire Hospital. Northern General Hospital) ; Thompson, R. (Royal Hallamshire Hospital. Northern General Hospital) ; Watson, J. (Royal Hallamshire Hospital. Northern General Hospital) ; Hesseldon, L. (Royal Hallamshire Hospital. Northern General Hospital) ; Macharia, I. (Royal Hallamshire Hospital. Northern General Hospital) ; Chetam, L. (Royal Hallamshire Hospital. Northern General Hospital) ; Smith, J. (Russell's Hall Hospital) ; Ford, A. (Royal Hallamshire Hospital. Northern General Hospital) ; Anderson, S. (Hereford County Hospital) ; Birchall, K. (Royal Hallamshire Hospital. Northern General Hospital) ; Housley, K. (Royal Hallamshire Hospital. Northern General Hospital) ; Walker, S. (Royal Hallamshire Hospital. Northern General Hospital) ; Milner, L. (Royal Hallamshire Hospital. Northern General Hospital) ; Hanratty, H. (Royal Hallamshire Hospital. Northern General Hospital) ; Trower, H. (Royal Hallamshire Hospital. Northern General Hospital) ; Phillips, P. (Royal Hallamshire Hospital. Northern General Hospital) ; Oxspring, S. (Royal Hallamshire Hospital. Northern General Hospital) ; Donne, B. (Royal Hallamshire Hospital. Northern General Hospital) ; Jardine, C. (Dumfries and Galloway Royal Infirmary) ; Williams, D. (Dumfries and Galloway Royal Infirmary) ; Hay, A. (Dumfries and Galloway Royal Infirmary) ; Flanagan, R. (Royal Bolton Hospital) ; Hughes, G. (Royal Bolton Hospital) ; Latham, S. (Royal Bolton Hospital) ; McKenna, E. (Royal Bolton Hospital) ; Anderson, J. (Royal Bolton Hospital) ; Hull, R. (Royal Bolton Hospital) ; Rhead, K. (Royal Bolton Hospital) ; Cruz, C. (Lister Hospital) ; Pattison, N. (Lister Hospital) ; Charnock, R. (Craigavon Area Hospital) ; McFarland, D. (Craigavon Area Hospital) ; Cosgrove, D. (Craigavon Area Hospital) ; Ahmed, A. (Southport and Formby District General Hospital) ; Morris, A. (Southport and Formby District General Hospital) ; Jakkula, S. (Southport and Formby District General Hospital) ; Nune, A. (Southport and Formby District General Hospital) ; Ali, A. (Department of Health Sciences. University of Leicester) ; Brady, M. (Huddersfield Royal Infirmary) ; Dale, S. (Huddersfield Royal Infirmary) ; Dance, A. (Huddersfield Royal Infirmary) ; Gledhill, L. (Huddersfield Royal Infirmary) ; Greig, J. (Huddersfield Royal Infirmary) ; Hanson, K. (Huddersfield Royal Infirmary) ; Holdroyd, K. (Huddersfield Royal Infirmary) ; Home, M. (Huddersfield Royal Infirmary) ; Kelly, D. (Huddersfield Royal Infirmary) ; Kitson, R. (Huddersfield Royal Infirmary) ; Matapure, L. (Huddersfield Royal Infirmary) ; Melia, D. (Huddersfield Royal Infirmary) ; Mellor, S. (Huddersfield Royal Infirmary) ; Nortcliffe, T. (Huddersfield Royal Infirmary) ; Pinnell, J. (Huddersfield Royal Infirmary) ; Robinson, M. (Huddersfield Royal Infirmary) ; Shaw, L. (Huddersfield Royal Infirmary) ; Shaw, R. (Huddersfield Royal Infirmary) ; Thomis, L. (Huddersfield Royal Infirmary) ; Wilson, A. (Huddersfield Royal Infirmary) ; Wood, T. (Huddersfield Royal Infirmary) ; Bayo, L.A. (Huddersfield Royal Infirmary) ; Merwaha, E. (Huddersfield Royal Infirmary) ; Ishaq, T. (Huddersfield Royal Infirmary) ; Hanley, S. (Huddersfield Royal Infirmary) ; Hibbert, M. (Prince Charles Hospital) ; Tetla, D. (Prince Charles Hospital) ; Woodford, C. (Prince Charles Hospital) ; Durga, L. (Prince Charles Hospital) ; Kennard-Holden, G. (Prince Charles Hospital) ; Branney, D. (Royal Bournemouth Hospital) ; Frankham, J. (Royal Bournemouth Hospital) ; Pitts, S. (Royal Bournemouth Hospital) ; White, N. (The Princess Alexandra Hospital) ; Laha, S. (Royal Preston Hospital) ; Verlander, M. (Royal Preston Hospital) ; Williams, A. (St John's Hospital Livingston) ; Altabaibeh, A. (Whittington Hospital) ; Alvaro, A. (Whittington Hospital) ; Gilbert, K. (Whittington Hospital) ; Ma, L. (Whittington Hospital) ; Mostoles, L. (Whittington Hospital) ; Parmar, C. (Whittington Hospital) ; Simpson, K. (Royal Lancaster Infirmary) ; Jetha, C. (Whittington Hospital) ; Booker, L. (Whittington Hospital) ; Pratley, A. (Whittington Hospital) ; Adams, C. (Princess Royal Hospital. Telford and Royal Shrewsbury Hospital) ; Agasou, A. (Princess Royal Hospital. Telford and Royal Shrewsbury Hospital) ; Arden, T. (Princess Royal Hospital. Telford and Royal Shrewsbury Hospital) ; Bowes, A. (Princess Royal Hospital. Telford and Royal Shrewsbury Hospital) ; Boyle, P. (Princess Royal Hospital. Telford and Royal Shrewsbury Hospital) ; Beekes, M. (Princess Royal Hospital. Telford and Royal Shrewsbury Hospital) ; Button, H. (Princess Royal Hospital. Telford and Royal Shrewsbury Hospital) ; Capps, N. (Princess Royal Hospital. Telford and Royal Shrewsbury Hospital) ; Carnahan, M. (Princess Royal Hospital. Telford and Royal Shrewsbury Hospital) ; Carter, A. (Princess Royal Hospital. Telford and Royal Shrewsbury Hospital) ; Childs, D. (Princess Royal Hospital. Telford and Royal Shrewsbury Hospital) ; Donaldson, D. (Princess Royal Hospital. Telford and Royal Shrewsbury Hospital) ; Hard, K. (Princess Royal Hospital. Telford and Royal Shrewsbury Hospital) ; Hurford, F. (Princess Royal Hospital. Telford and Royal Shrewsbury Hospital) ; Hussain, Y. (Princess Royal Hospital. Telford and Royal Shrewsbury Hospital) ; Javaid, A. (Princess Royal Hospital. Telford and Royal Shrewsbury Hospital) ; Jones, J. (Princess Royal Hospital. Telford and Royal Shrewsbury Hospital) ; Jose, S. (Princess Royal Hospital. Telford and Royal Shrewsbury Hospital) ; Leigh, M. (Princess Royal Hospital. Telford and Royal Shrewsbury Hospital) ; Martin, T. (Princess Royal Hospital. Telford and Royal Shrewsbury Hospital) ; Millward, H. (Princess Royal Hospital. Telford and Royal Shrewsbury Hospital) ; Motherwell, N. (Princess Royal Hospital. Telford and Royal Shrewsbury Hospital) ; Rikunenko, R. (Princess Royal Hospital. Telford and Royal Shrewsbury Hospital) ; Stickley, J. (Princess Royal Hospital. Telford and Royal Shrewsbury Hospital) ; Summers, J. (Princess Royal Hospital. Telford and Royal Shrewsbury Hospital) ; Ting, L. (Princess Royal Hospital. Telford and Royal Shrewsbury Hospital) ; Tivenan, H. (Princess Royal Hospital. Telford and Royal Shrewsbury Hospital) ; Tonks, L. (Princess Royal Hospital. Telford and Royal Shrewsbury Hospital) ; Wilcox, R. (Princess Royal Hospital. Telford and Royal Shrewsbury Hospital) ; Skinner, D. (Princess Royal Hospital) ; Gaylard, J. (Princess Royal Hospital) ; Mullan, D. (Princess Royal Hospital) ; Newman, J. (Princess Royal Hospital) ; Holland, M. (Macclesfield District General Hospital) ; Keenan, N. (Macclesfield District General Hospital) ; Lyons, Marc (Macclesfield District General Hospital) ; Wassall, H. (Macclesfield District General Hospital) ; Marsh, C. (Macclesfield District General Hospital) ; Mahenthran, M. (Macclesfield District General Hospital) ; Carter, E. (Macclesfield District General Hospital) ; Kong, T. (Macclesfield District General Hospital) ; Blackman, H. (Royal Surrey County Hospital) ; Creagh-Brown, B. (Royal Surrey County Hospital) ; Donlon, S. (Royal Surrey County Hospital) ; Michalak-Glinska, N. (Royal Surrey County Hospital) ; Mtuwa, S. (Royal Surrey County Hospital) ; Pristopan, V. (Royal Surrey County Hospital) ; Salberg, A. (Royal Surrey County Hospital) ; Smith, E. (Royal Surrey County Hospital) ; Stone, S. (Royal Surrey County Hospital) ; Piercy, C. (Royal Surrey County Hospital) ; Verula, J. (Royal Surrey County Hospital) ; Burda, D. (Royal Surrey County Hospital) ; Montaser, R. (Royal Surrey County Hospital) ; Harden, L. (Royal Surrey County Hospital) ; Mayangao, I. (Royal Surrey County Hospital) ; Marriott, C. (Royal Surrey County Hospital) ; Bradley, P. (Royal Surrey County Hospital) ; Harris, C. (Royal Surrey County Hospital) ; Anderson, S. (Hereford County Hospital) ; Andrews, E. (Hereford County Hospital) ; Birch, J. (Dorset County Hospital) ; Collins, E. (Royal Victoria Hospital) ; Hammerton, K. (Hereford County Hospital) ; O'Leary, R. (Hereford County Hospital) ; Clark, M. (University Hospital of North Tees) ; Purvis, S. (University Hospital of North Tees) ; Barber, R. (Lincoln County Hospital) ; Hewitt, C. (Lincoln County Hospital) ; Hilldrith, A. (Lincoln County Hospital) ; Jackson-Lawrence, K. (Lincoln County Hospital) ; Shepardson, S. (Lincoln County Hospital) ; Wills, M. (Lincoln County Hospital) ; Butler, S. (Lincoln County Hospital) ; Tavares, S. (Lincoln County Hospital) ; Cunningham, A. (Lincoln County Hospital) ; Hindale, J. (Lincoln County Hospital) ; Arif, S. (Lincoln County Hospital) ; Bean, S. (Royal Cornwall Hospital) ; Burt, K. (Royal Cornwall Hospital) ; Spivey, M. (Royal Cornwall Hospital) ; Demetriou, C. (Royal United Hospital) ; Eckbad, C. (Royal United Hospital) ; Hierons, S. (Royal United Hospital) ; Howie, L. (Royal United Hospital) ; Mitchard, S. (Royal United Hospital) ; Ramos, L. (Royal United Hospital) ; Serrano-Ruiz, A. (Royal United Hospital) ; White, K. (Royal United Hospital) ; Kelly, F. (Royal United Hospital) ; Cristiano, D. (Royal Brompton Hospital (Londres)) ; Dormand, N. (Royal Brompton Hospital (Londres)) ; Farzad, Z. (Royal Brompton Hospital (Londres)) ; Gummadi, M. (Royal Brompton Hospital (Londres)) ; Liyanage, K. (Royal Brompton Hospital (Londres)) ; Patel, B. (Royal Brompton Hospital (Londres)) ; Salmi, S. (Royal Brompton Hospital (Londres)) ; Sloane, G. (Royal Brompton Hospital (Londres)) ; Thwaites, V. (Royal Brompton Hospital (Londres)) ; Varghese, M. (Royal Brompton Hospital (Londres)) ; Zborowski, A.C. (Royal Brompton Hospital (Londres)) ; Allan, J. (University Hospital Crosshouse) ; Geary, T. (University Hospital Crosshouse) ; Houston, G. (University Hospital Crosshouse) ; Meikle, A. (University Hospital Crosshouse) ; O'Brien, P. (University Hospital Crosshouse) ; Forsey, M. (Basildon Hospital) ; Kaliappan, A. (Basildon Hospital) ; Nicholson, A. (Barnsley Hospital) ; Riches, J. (Basildon Hospital) ; Vertue, M. (Basildon Hospital) ; Allan, E. (Glan Clwyd Hospital) ; Darlington, K. (Glan Clwyd Hospital) ; Davies, F. (Glan Clwyd Hospital) ; Easton, J. (Glan Clwyd Hospital) ; Kumar, S. (Glan Clwyd Hospital) ; Lean, R. (Glan Clwyd Hospital) ; Menzies, D. (Glan Clwyd Hospital) ; Pugh, R. (Glan Clwyd Hospital) ; Qiu, X. (Glan Clwyd Hospital) ; Davies, L. (Glan Clwyd Hospital) ; Williams, H. (Glan Clwyd Hospital) ; Scanlon, J. (Glan Clwyd Hospital) ; Davies, G. (Glan Clwyd Hospital) ; Mackay, C. (Glan Clwyd Hospital) ; Lewis, J. (Glan Clwyd Hospital) ; Rees, S. (Glan Clwyd Hospital) ; Oblak, M. (West Middlesex Hospital) ; Popescu, M. (West Middlesex Hospital) ; Thankachen, M. (West Middlesex Hospital) ; Higham, A. (Royal Lancaster Infirmary) ; Simpson, K. (Royal Lancaster Infirmary) ; Craig, J. (Royal Lancaster Infirmary) ; Baruah, R. (Western General Hospital) ; Morris, S. (Western General Hospital) ; Ferguson, S. (Western General Hospital) ; Shepherd, A. (Western General Hospital) ; Moore, L.S.P. (Chelsea and Westminster NHS Foundation Trust) ; Vizcaychipi, M.P. (Chelsea and Westminster NHS Foundation Trust) ; de Almeida Martins, L.G. (Chelsea and Westminster NHS Foundation Trust) ; Carungcong, J. (Chelsea and Westminster NHS Foundation Trust) ; Ali, I.A.M. (The Queen Elizabeth Hospital) ; Beaumont, K. (The Queen Elizabeth Hospital) ; Blunt, M. (The Queen Elizabeth Hospital) ; Coton, Z. (The Queen Elizabeth Hospital) ; Curgenven, H. (The Queen Elizabeth Hospital) ; Elsaadany, M. (The Queen Elizabeth Hospital) ; Fernandes, K. (The Queen Elizabeth Hospital) ; Ally, S.M. (The Queen Elizabeth Hospital) ; Rangarajan, H. (The Queen Elizabeth Hospital) ; Sarathy, V. (The Queen Elizabeth Hospital) ; Selvanayagam, S. (The Queen Elizabeth Hospital) ; Vedage, D. (The Queen Elizabeth Hospital) ; White, M. (The Queen Elizabeth Hospital) ; Gill, M. (King's Mill Hospital) ; Paul, P. (King's Mill Hospital) ; Ratnam, V. (King's Mill Hospital) ; Shelton, S. (King's Mill Hospital) ; Wynter, I. (King's Mill Hospital) ; Carmody, S. (Watford General Hospital) ; Page, V.J. (Watford General Hospital) ; Beith, C.M. (University Hospital Wishaw) ; Black, K. (University Hospital Wishaw) ; Clements, S. (University Hospital Wishaw) ; Morrison, A. (University Hospital Wishaw) ; Strachan, D. (University Hospital Wishaw) ; Taylor, M. (University Hospital Wishaw) ; Clarkson, M. (University Hospital Wishaw) ; D'Sylva, S. (University Hospital Wishaw) ; Norman, K. (University Hospital Wishaw) ; Auld, F. (Forth Valley Royal Hospital) ; Donnachie, J. (Forth Valley Royal Hospital) ; Edmond, I. (Forth Valley Royal Hospital) ; Prentice, L. (Forth Valley Royal Hospital) ; Runciman, N. (Forth Valley Royal Hospital) ; Salutous, D. (Forth Valley Royal Hospital) ; Symon, L. (Forth Valley Royal Hospital) ; Todd, A. (Forth Valley Royal Hospital) ; Turner, P. (Forth Valley Royal Hospital) ; Short, A. (Forth Valley Royal Hospital) ; Sweeney, L. (Forth Valley Royal Hospital) ; Murdoch, E. (Forth Valley Royal Hospital) ; Senaratne, D. (Forth Valley Royal Hospital) ; Hill, M. (George Eliot Hospital NHS Trust) ; Kannan, T. (George Eliot Hospital NHS Trust) ; Crawley, R. (Barnsley Hospital) ; Crew, A. (Barnsley Hospital) ; Cunningham, M. (Barnsley Hospital) ; Daniels, A. (Barnsley Hospital) ; Harrison, L. (Barnsley Hospital) ; Hope, S. (Barnsley Hospital) ; Inweregbu, K. (Barnsley Hospital) ; Jones, S. (Barnsley Hospital) ; Lancaster, N. (Barnsley Hospital) ; Matthews, J. (Barnsley Hospital) ; Nicholson, A. (Barnsley Hospital) ; Wray, G. (Barnsley Hospital) ; Langton, H. (The Great Western Hospital) ; Prout, R. (The Great Western Hospital) ; Watters, M. (The Great Western Hospital) ; Novis, C. (The Great Western Hospital) ; Barron, A. (Harefield Hospital) ; Collins, C. (Harefield Hospital) ; Kaul, S. (Harefield Hospital) ; Passmore, H. (Harefield Hospital) ; Prendergast, C. (Harefield Hospital) ; Reed, A. (Harefield Hospital) ; Rogers, P. (Harefield Hospital) ; Shokkar, R. (Harefield Hospital) ; Woodruff, M. (Harefield Hospital) ; Middleton, H. (Harefield Hospital) ; Polgar, O. (Harefield Hospital) ; Nolan, C. (Harefield Hospital) ; Mahay, K. (Harefield Hospital) ; Collier, D. (Rotherham General Hospital) ; Hormis, A. (Rotherham General Hospital) ; Maynard, V. (Rotherham General Hospital) ; Graham, C. (Rotherham General Hospital) ; Walker, R. (Rotherham General Hospital) ; Knights, E. (Ysbyty Gwynedd) ; Price, A. (Ysbyty Gwynedd) ; Thomas, A. (Ysbyty Gwynedd) ; Thorpe, C. (Ysbyty Gwynedd) ; Behan, T. (Diana Princess of Wales Hospital) ; Burnett, C. (Diana Princess of Wales Hospital) ; Hatton, J. (Diana Princess of Wales Hospital) ; Heeney, E. (Diana Princess of Wales Hospital) ; Mitra, A. (Diana Princess of Wales Hospital) ; Newton, M. (Diana Princess of Wales Hospital) ; Pollard, R. (Diana Princess of Wales Hospital) ; Stead, R. (Diana Princess of Wales Hospital) ; Amin, V. (Russell's Hall Hospital) ; Anastasescu, E. (Russell's Hall Hospital) ; Anumakonda, V. (Russell's Hall Hospital) ; Karthik, K. (Russell's Hall Hospital) ; Kausar, R. (Russell's Hall Hospital) ; Reid, K. (Russell's Hall Hospital) ; Smith, J. (Russell's Hall Hospital) ; Imeson-Wood, J. (Russell's Hall Hospital) ; Brown, A. (St Mary's Hospital) ; Crickmore, V. (St Mary's Hospital) ; Debreceni, G. (St Mary's Hospital) ; Wilkins, J. (St Mary's Hospital) ; Nicol, L. (St Mary's Hospital) ; Reece-Anthony, R. (University Hospital Lewisham) ; Birt, M. (University Hospital Lewisham) ; Ghosh, A. (Colchester General Hospital) ; Williams, E. (Colchester General Hospital) ; Allen, L. (Queen Elizabeth the Queen Mother Hospital) ; Beranova, E. (Queen Elizabeth the Queen Mother Hospital) ; Crisp, N. (Queen Elizabeth the Queen Mother Hospital) ; Deery, J. (Queen Elizabeth the Queen Mother Hospital) ; Hazelton, T. (Queen Elizabeth the Queen Mother Hospital) ; Knight, A. (Queen Elizabeth the Queen Mother Hospital) ; Price, C. (Queen Elizabeth the Queen Mother Hospital) ; Tilbey, S. (Queen Elizabeth the Queen Mother Hospital) ; Turki, S. (Queen Elizabeth the Queen Mother Hospital) ; Turney, S. (Queen Elizabeth the Queen Mother Hospital) ; Cooper, J. (Royal Albert Edward Infirmary) ; Finch, C. (Royal Albert Edward Infirmary) ; Liderth, S. (Royal Albert Edward Infirmary) ; Quinn, A. (Royal Albert Edward Infirmary) ; Waddington, N. (Royal Albert Edward Infirmary) ; Coventry, T. (Victoria Hospital) ; Fowler, S. (Victoria Hospital) ; MacMahon, M. (Victoria Hospital) ; McGregor, A. (Northwick Park Hospital) ; Cowley, A. (Conquest Hospital) ; Highgate, J. (Conquest Hospital) ; Gregory, J. (Cumberland Infirmary) ; O'Connell, S. (Cumberland Infirmary) ; Smith, T. (Cumberland Infirmary) ; Barberis, L. (Cumberland Infirmary) ; Gopal, S. (New Cross Hospital) ; Harris, N. (New Cross Hospital) ; Lake, V. (New Cross Hospital) ; Metherell, S. (New Cross Hospital) ; Radford, E. (New Cross Hospital) ; Daniel, A. (The Princess Alexandra Hospital) ; Finn, J. (The Princess Alexandra Hospital) ; Saha, R. (The Princess Alexandra Hospital) ; White, N. (The Princess Alexandra Hospital) ; Donnison, P. (Salisbury District Hospital) ; Trim, F. (Salisbury District Hospital) ; Eapen, B. (Salisbury District Hospital) ; Birch, J. (Dorset County Hospital) ; Bough, L. (Dorset County Hospital) ; Goodsell, J. (Dorset County Hospital) ; Tutton, R. (Dorset County Hospital) ; Williams, P. (Dorset County Hospital) ; Williams, S. (Dorset County Hospital) ; Winter-Goodwin, B. (Dorset County Hospital) ; Brickell, K. (University College Dublin. St Vincent's University Hospital) ; Smyth, M. (University College Dublin. St Vincent's University Hospital) ; Murphy, L. (University College Dublin. St Vincent's University Hospital) ; Coetzee, S. (Glangwili General Hospital) ; Gales, A. (Glangwili General Hospital) ; Raj, M. (Glangwili General Hospital) ; Sell, C. (Glangwili General Hospital) ; Hilltout, P. (Gloucestershire Royal Hospital) ; Evitts, J. (Gloucestershire Royal Hospital) ; Tyler, A. (Gloucestershire Royal Hospital) ; Waldron, J. (Gloucestershire Royal Hospital) ; Beesley, K. (Yeovil Hospital) ; Board, S. (Yeovil Hospital) ; Kubisz-Pudelko, A. (Yeovil Hospital) ; Lewis, A. (Yeovil Hospital) ; Perry, J. (Yeovil Hospital) ; Pippard, L. (Yeovil Hospital) ; Wood, D. (Yeovil Hospital) ; Buckley, C. (Yeovil Hospital) ; Barry, P. (Leicester Royal Infirmary) ; Flint, N. (Leicester Royal Infirmary) ; Rekha, P. (Leicester Royal Infirmary) ; Hales, D. (Leicester Royal Infirmary) ; Bunni, L. (Royal Manchester Children's Hospital) ; Jennings, C. (Royal Manchester Children's Hospital) ; Latif, M. (Royal Manchester Children's Hospital) ; Marshall, R. (Royal Manchester Children's Hospital) ; Subramanian, G. (Royal Manchester Children's Hospital) ; McGuigan, P.J. (Royal Victoria Hospital) ; Wasson, C. (Royal Victoria Hospital) ; Finn, S. (Royal Victoria Hospital) ; Green, J. (Royal Victoria Hospital) ; Collins, E. (Royal Victoria Hospital) ; King, B. (Royal Victoria Hospital) ; Campbell, A. (Institute of Genetics and Cancer. University of Edinburgh. Western General Hospital) ; Smuts, S. (Wrexham Maelor Hospital) ; Duffield, J. (Wrexham Maelor Hospital) ; Smith, O. (Wrexham Maelor Hospital) ; Mallon, L. (Wrexham Maelor Hospital) ; Watkins, C. (Wrexham Maelor Hospital) ; Botfield, L. (Walsall Manor Hospital) ; Butler, J. (Walsall Manor Hospital) ; Dexter, C. (Walsall Manor Hospital) ; Fletcher, J. (Walsall Manor Hospital) ; Garg, A. (Walsall Manor Hospital) ; Kuravi, A. (Walsall Manor Hospital) ; Ranga, P. (Walsall Manor Hospital) ; Virgilio, E. (Walsall Manor Hospital) ; Belagodu, Z. (Darent Valley Hospital) ; Fuller, B. (Darent Valley Hospital) ; Gherman, A. (Darent Valley Hospital) ; Olufuwa, O. (Darent Valley Hospital) ; Paramsothy, R. (Darent Valley Hospital) ; Stuart, C. (Darent Valley Hospital) ; Oakley, N. (Darent Valley Hospital) ; Kamundi, C. (Darent Valley Hospital) ; Tyl, D. (Darent Valley Hospital) ; Collins, K. (Darent Valley Hospital) ; Silva, P. (Darent Valley Hospital) ; Taylor, J. (Darent Valley Hospital) ; King, L. (Darent Valley Hospital) ; Coates, C. (Darent Valley Hospital) ; Crowley, M. (Darent Valley Hospital) ; Wakefield, P. (Darent Valley Hospital) ; Beadle, J. (Darent Valley Hospital) ; Johnson, L. (Darent Valley Hospital) ; Sargeant, J. (Darent Valley Hospital) ; Anderson, M. (Darent Valley Hospital) ; Brady, A. (Warrington General Hospital) ; Chan, R. (Warrington General Hospital) ; Little, J. (Warrington General Hospital) ; McIvor, S. (Warrington General Hospital) ; Prady, H. (Warrington General Hospital) ; Whittle, H. (Warrington General Hospital) ; Mathew, B. (Warrington General Hospital) ; Attwood, B. (Warwick Hospital) ; Parsons, P. (Warwick Hospital) ; Ward, G. (University Hospitals Coventry. Warwickshire NHS Trust) ; Bremmer, P. (University Hospitals Coventry. Warwickshire NHS Trust) ; Joe, W. (University Hospital Monklands) ; Tracy, B. (University Hospital Monklands) ; Jim, R. (University Hospital Monklands) ; Davies, E. (Princess of Wales Hospital) ; Roche, L. (Princess of Wales Hospital) ; Sathe, S. (Princess of Wales Hospital) ; Dennis, C. (Northwick Park Hospital) ; McGregor, A. (Northwick Park Hospital) ; Parris, V. (Northwick Park Hospital) ; Srikaran, S. (Northwick Park Hospital) ; Sukha, A. (Northwick Park Hospital) ; Clarke, N. (Raigmore Hospital) ; Whiteside, J. (Raigmore Hospital) ; Mascarenhas, M. (Raigmore Hospital) ; Donaldson, A. (Raigmore Hospital) ; Matheson, J. (Raigmore Hospital) ; Barrett, F. (Raigmore Hospital) ; O'Hara, M. (Raigmore Hospital) ; Okeefe, L. (Raigmore Hospital) ; Bradley, C. (Raigmore Hospital) ; Eastgate-Jackson, C. (Royal Free Hospital) ; Filipe, H. (Royal Free Hospital) ; Martin, D. (Royal Free Hospital) ; Maharajh, A. (Royal Free Hospital) ; Garcia, S.M. (Royal Free Hospital) ; Pakou, G. (Royal Free Hospital) ; De Neef, M. (Royal Free Hospital) ; Dent, K. (Scunthorpe General Hospital) ; Horsley, E. (Scunthorpe General Hospital) ; Akhtar, M.N. (Scunthorpe General Hospital) ; Pearson, S. (Scunthorpe General Hospital) ; Potoczna, D. (Scunthorpe General Hospital) ; Spencer, S. (Scunthorpe General Hospital) ; Clapham, M. (West Cumberland Hospital) ; Harper, R. (West Cumberland Hospital) ; Poultney, U. (West Cumberland Hospital) ; Rice, P. (West Cumberland Hospital) ; Mutch, R. (West Cumberland Hospital) ; Armstrong, L. (Airedale General Hospital) ; Bates, H. (Airedale General Hospital) ; Dooks, E. (Airedale General Hospital) ; Farquhar, F. (Airedale General Hospital) ; Hairsine, B. (Airedale General Hospital) ; McParland, C. (Airedale General Hospital) ; Packham, S. (Airedale General Hospital) ; Bi, R. (Birmingham Children's Hospital) ; Scholefield, B. (Birmingham Children's Hospital) ; Ashton, L. (Birmingham Children's Hospital) ; George, L. (Liverpool Heart and Chest Hospital) ; Twiss, S. (Liverpool Heart and Chest Hospital) ; Wright, D. (Liverpool Heart and Chest Hospital) ; Chablani, M. (Pilgrim Hospital) ; Kirkby, A. (Pilgrim Hospital) ; Netherton, K. (Pilgrim Hospital) ; Davies, K. (Prince Philip Hospital) ; O'Brien, L. (Prince Philip Hospital) ; Omar, Z. (Prince Philip Hospital) ; Otahal, I. (Prince Philip Hospital) ; Perkins, E. (Prince Philip Hospital) ; Lewis, T. (Prince Philip Hospital) ; Sutherland, I. (Prince Philip Hospital) ; Burns, K. (Furness General Hospital) ; Chandler, B. (Scarborough General Hospital) ; Elliott, K. (Scarborough General Hospital) ; Mallinson, J. (Scarborough General Hospital) ; Turnbull, A. (Scarborough General Hospital) ; Gondo, P. (Southend University Hospital) ; Hadebe, B. (Southend University Hospital) ; Kayani, A. (Southend University Hospital) ; Masunda, B. (Southend University Hospital) ; Anderson, T. (Alder Hey Children's Hospital) ; Hawcutt, D. (Alder Hey Children's Hospital) ; O'Malley, L. (Alder Hey Children's Hospital) ; Rad, L. (Alder Hey Children's Hospital) ; Rogers, N. (Alder Hey Children's Hospital) ; Saunderson, P. (Alder Hey Children's Hospital) ; Allison, K.S. (Alder Hey Children's Hospital) ; Afolabi, D. (Alder Hey Children's Hospital) ; Whitbread, J. (Alder Hey Children's Hospital) ; Jones, D. (Alder Hey Children's Hospital) ; Dore, R. (Alder Hey Children's Hospital) ; Halkes, M. (Torbay Hospital) ; Mercer, P. (Torbay Hospital) ; Thornton, L. (Torbay Hospital) ; Dawson, J. (Borders General Hospital) ; Garrioch, S. (Borders General Hospital) ; Tolson, M. (Borders General Hospital) ; Aldridge, J. (Borders General Hospital) ; Kapoor, R. (Kent and Canterbury Hospital) ; Loader, D. (Kent and Canterbury Hospital) ; Castle, K. (Kent and Canterbury Hospital) ; Humphreys, S. (West Suffolk Hospital) ; Tampsett, R. (West Suffolk Hospital) ; Mackintosh, K. (James Paget University Hospital NHS Trust) ; Ayers, A. (James Paget University Hospital NHS Trust) ; Harrison, W. (James Paget University Hospital NHS Trust) ; North, J. (James Paget University Hospital NHS Trust) ; Allibone, S. (The Christie NHS Foundation Trust) ; Genetu, R. (The Christie NHS Foundation Trust) ; Kasipandian, V. (The Christie NHS Foundation Trust) ; Patel, A. (The Christie NHS Foundation Trust) ; Mac, A. (The Christie NHS Foundation Trust) ; Murphy, A. (The Christie NHS Foundation Trust) ; Mahjoob, P. (The Christie NHS Foundation Trust) ; Nazari, R. (The Christie NHS Foundation Trust) ; Worsley, L. (The Christie NHS Foundation Trust) ; Fagan, A. (The Christie NHS Foundation Trust) ; Bemand, T. (The Royal Marsden Hospital) ; Black, E. (The Royal Marsden Hospital) ; Rosa, A.D. (The Royal Marsden Hospital) ; Howle, R. (The Royal Marsden Hospital) ; Jhanji, S. (The Royal Marsden Hospital) ; Baikady, R.R. (The Royal Marsden Hospital) ; Tatham, K.C. (The Royal Marsden Hospital) ; Thomas, B. (The Royal Marsden Hospital) ; Bell, D. (University Hospital Hairmyres) ; Boyle, R. (University Hospital Hairmyres) ; Douglas, K. (University Hospital Hairmyres) ; Glass, L. (University Hospital Hairmyres) ; Lee, E. (University Hospital Hairmyres) ; Lennon, L. (University Hospital Hairmyres) ; Rattray, A. (University Hospital Hairmyres) ; Taylor, A. (Withybush General Hospital) ; Hughes, R.A. (Withybush General Hospital) ; Thomas, H. (Withybush General Hospital) ; Rees, A. (Withybush General Hospital) ; Duskova, M. (Withybush General Hospital) ; Phipps, J. (Withybush General Hospital) ; Brooks, S. (Withybush General Hospital) ; Edwards, M. (Withybush General Hospital) ; Quaid, S. (Ealing Hospital) ; Watson, E. (Ealing Hospital) ; Brayne, A. (North Devon District Hospital) ; Fisher, Emma (North Devon District Hospital) ; Hunt, J. (North Devon District Hospital) ; Jackson, P. (North Devon District Hospital) ; Kaye, D. (North Devon District Hospital) ; Love, N. (North Devon District Hospital) ; Parkin, J. (North Devon District Hospital) ; Tuckey, V. (North Devon District Hospital) ; van Koutrik, L. (North Devon District Hospital) ; Carter, S. (North Devon District Hospital) ; Andrew, B. (North Devon District Hospital) ; Findlay, L. (North Devon District Hospital) ; Adams, K. (North Devon District Hospital) ; Service, J. (St John's Hospital Livingston) ; Williams, A. (St John's Hospital Livingston) ; Cheyne, C. (St John's Hospital Livingston) ; Saunderson, A. (St John's Hospital Livingston) ; Moultrie, S. (St John's Hospital Livingston) ; Odam, M. (St John's Hospital Livingston) ; Hall, K. (Northampton General Hospital NHS Trust) ; Mapfunde, I. (Northampton General Hospital NHS Trust) ; Willis, C. (Northampton General Hospital NHS Trust) ; Lyon, A. (Northampton General Hospital NHS Trust) ; Sri-Chandana, C. (Harrogate and District NHS Foundation Trust) ; Scherewode, J. (Harrogate and District NHS Foundation Trust) ; Stephenson, L. (Harrogate and District NHS Foundation Trust) ; Marsh, S. (Harrogate and District NHS Foundation Trust) ; Hardy, J. (National Hospital for Neurology and Neurosurgery) ; Houlden, H. (National Hospital for Neurology and Neurosurgery) ; Moncur, E. (National Hospital for Neurology and Neurosurgery) ; Tariq, A. (National Hospital for Neurology and Neurosurgery) ; Tucci, A. (National Hospital for Neurology and Neurosurgery) ; Hobrok, M. (Bronglais General Hospital) ; Loosley, R. (Bronglais General Hospital) ; McGuinness, H. (Bronglais General Hospital) ; Tench, H. (Bronglais General Hospital) ; Wolf-Roberts, R. (Bronglais General Hospital) ; Irvine, V. (Golden Jubilee National Hospital) ; Shelley, B. (Golden Jubilee National Hospital) ; Gorman, C. (Homerton University Hospital Foundation NHS Trust) ; Gupta, A. (Homerton University Hospital Foundation NHS Trust) ; Timlick, E. (Homerton University Hospital Foundation NHS Trust) ; Brady, R. (Homerton University Hospital Foundation NHS Trust) ; Milligan, B. (Royal Hospital for Children) ; Bellini, A. (Sheffield Children's Hospital (Sheffield, Regne Unit)) ; Bryant, J. (Sheffield Children's Hospital (Sheffield, Regne Unit)) ; Mayer, A. (Sheffield Children's Hospital (Sheffield, Regne Unit)) ; Pickard, A. (Sheffield Children's Hospital (Sheffield, Regne Unit)) ; Roe, N. (Sheffield Children's Hospital (Sheffield, Regne Unit)) ; Sowter, J. (Sheffield Children's Hospital (Sheffield, Regne Unit)) ; Howlett, A. (Sheffield Children's Hospital (Sheffield, Regne Unit)) ; Fidler, K. (The Royal Alexandra Children's Hospital) ; Tagliavini, E. (The Royal Alexandra Children's Hospital) ; Donnelly, K. (The Royal Alexandra Children's Hospital) ; Shelton, J.F. (23andMe) ; Shastri, A.J. (23andMe) ; Ye, C. (23andMe) ; Weldon, C.H. (23andMe) ; Filshtein-Sonmez, T. (23andMe) ; Coker, D. (23andMe) ; Symons, A. (23andMe) ; Esparza-Gordillo, J. (Human Genetics R&D and Target Sciences R&D. GSK Medicines Research Centre) ; Aslibekyan, S. (23andMe) ; Auton, A. (23andMe) ; Pathak, Gita (Yale University) ; Karjalainen, Juha (Institute for Molecular Medicine Finland (FIMM). University of Helsinki) ; Stevens, Christine (Broad Institute of MIT and Harvard) ; Andrews, Shea J. (Icahn School of Medicine at Mount Sinai) ; Kanai, Masahiro (Broad Institute of MIT and Harvard) ; Cordioli, Mattia (Institute for Molecular Medicine Finland (FIMM). University of Helsinki) ; Polimanti, Renato (Yale University) ; Pirinen, Matti (Institute for Molecular Medicine Finland (FIMM). University of Helsinki) ; Harerimana, Nadia V. (Icahn School of Medicine at Mount Sinai) ; Veerapen, Kumar (Broad Institute of MIT and Harvard) ; Wolford, Brooke N. (University of Michigan) ; Nguyen, Huy (Broad Institute of MIT and Harvard) ; Solomonson, Matthew (Broad Institute of MIT and Harvard) ; Liao, Rachel G. (Broad Institute of MIT and Harvard) ; Chwialkowska, Karolina (Centre for Bioinformatics and Data Analysis. Medical University of Bialystok) ; Trankiem, Amy (Broad Institute of MIT and Harvard) ; Balaconis, Mary K. (Broad Institute of MIT and Harvard) ; Hayward, Caroline (Institute of Genetics and Cancer. University of Edinburgh. Western General Hospital) ; Richmond, Anne (Institute of Genetics and Cancer. University of Edinburgh. Western General Hospital) ; Campbell, Archie (Institute of Genetics and Cancer. University of Edinburgh. Western General Hospital) ; Morris, Marcela (University of Texas Health) ; Fawns-Ritchie, Chloe (Institute of Genetics and Cancer. University of Edinburgh. Western General Hospital) ; Glessner, Joseph T. (Department of Pediatrics. Perelman School of Medicine. University of Pennsylvania) ; Shaw, Douglas M. (Vanderbilt University Medical Center) ; Chang, Xiao (Center for Applied Genomics. Children's Hospital of Philadelphia) ; Polikowski, Hannah (Vanderbilt University Medical Center) ; Petty, Lauren E. (Vanderbilt University Medical Center) ; Chen, Hung-Hsin (Vanderbilt University Medical Center) ; Wanying, Zhu (Vanderbilt University Medical Center) ; Porteous, David J. (Institute of Genetics and Cancer. University of Edinburgh. Western General Hospital) ; Below, Jennifer (Vanderbilt University Medical Center) ; North, Kari (University of North Carolina at Chapel Hill) ; McCormick, Joseph B. (University of Texas Health) ; Timmers, Paul R.H.J. (Institute of Genetics and Cancer. University of Edinburgh. Western General Hospital) ; D'Mellow, Kenton (Roslin Institute. The Royal (Dick) School of Veterinary Studies. University of Edinburgh) ; Kerr, Shona M. (Institute of Genetics and Cancer. University of Edinburgh. Western General Hospital) ; Niemi, Mari E.K. (Institute for Molecular Medicine Finland (FIMM). University of Helsinki) ; Nkambul, Lindokuhle (Stanley Center for Psychiatric Research and Program in Medical and Population Genetics) ; von Hohenstaufen, Kathrin Aprile (Genolier Innovation Network and Hub. Swiss Medical Network) ; Sobh, Ali (Department of Pediatrics. Faculty of Medicine. Mansoura University) ; Eltoukhy, Madonna M. (Department of Clinical Pathology. Faculty of Medicine. Tanta University) ; Yassen, Amr M. (Department of Anaethesia and Critical Care. Faculty of Medicine. Mansoura University) ; Hegazy, Mohamed A.F. (Department of Surgery. Faculty of Medicine. Mansoura University) ; Okasha, Kamal (Department of Internal Medicine. Faculty of Medicine. Tanta University) ; Eid, Mohammed A. (Faculty of Science. Tanta University) ; Moahmed, Hanteera S. (Chest Department. Faculty of Medicine. Tanta University) ; Shahin, Doaa (Department of Clinical Pathology. Faculty of Medicine. Mansoura University) ; El-Sherbiny, Yasser M. (Department of Biosciences. School of Science and Technology. Nottingham Trent University) ; Elhadidy, Tamer A. (Chest Department. Faculty of Medicine. Mansoura University) ; Abd Elghafar, Mohamed S. (Anesthesia. Surgical Intensive Care and Pain Management Department. Faculty of Medicine. Tanta University) ; El-Jawhari, Jehan J. (Department of Biosciences. School of Science and Technology. Nottingham Trent University) ; Mohamed, Attia A.S. (Department of Clinical Pathology. Faculty of Medicine. Tanta University) ; Elnagdy, Marwa H. (Department of Medical Biochemistry. Faculty of Medicine. Mansoura University) ; Samir, Amr (Department of Surgery. Faculty of Medicine. Mansoura University) ; Abdel-Aziz, Mahmoud (Department of Tropical Medicine. Faculty of Medicine. Mansoura University) ; Khafaga, Walid T. (Kafr El-Zayat General Hospital) ; El-Lawaty, Walaa M. (Chest Department. Faculty of Medicine. Tanta University) ; Torky, Mohamed S. (Chest Department. Faculty of Medicine. Tanta University) ; El-shanshory, Mohamed R. (Pediatrics Department. Faculty of Medicine. Tanta University) ; Batini, Chiara (Department of Health Sciences. University of Leicester) ; Lee, Paul H. (Department of Health Sciences. University of Leicester) ; Shrine, Nick (Department of Health Sciences. University of Leicester) ; Williams, Alexander T. (Department of Health Sciences. University of Leicester) ; Tobin, Martin D. (Leicester NIHR Biomedical Research Centre) ; Guyatt, Anna L. (Department of Health Sciences. University of Leicester) ; John, Catherine (Department of Health Sciences. University of Leicester) ; Packer, Richard J. (Department of Health Sciences. University of Leicester) ; Ali, Altaf (Department of Health Sciences. University of Leicester) ; Free, Robert C. (Department of Respiratory Sciences. University of Leicester) ; Wang, Xueyang (Department of Health Sciences. University of Leicester) ; Wain, Louise V. (Department of Health Sciences. University of Leicester) ; Hollox, Edward J. (University of Leicester) ; Venn, Laura D. (Department of Health Sciences. University of Leicester) ; Bee, Catherine E. (Department of Health Sciences. University of Leicester) ; Adams, Emma L. (Department of Health Sciences. University of Leicester) ; Niavarani, Ahmadreza (Digestive Oncology Research Center. Digestive Disease Research Institute. Shariati Hospital. Tehran University of Medical Sciences) ; Sharififard, Bahareh (Digestive Oncology Research Center. Digestive Disease Research Institute. Shariati Hospital. Tehran University of Medical Sciences) ; Aliannejad, Rasoul (Department of Pulmonology. School of Medicine. Shariati Hospital. Tehran University of Medical Sciences) ; Amirsavadkouhi, Ali (Department of Critical Care Medicine. Noorafshar Hospital) ; Naderpour, Zeinab (Department of Pulmonology. School of Medicine. Shariati Hospital. Tehran University of Medical Sciences) ; Tadi, Hengameh A. (Department of Emergency Intensive Care Unit. School of Medicine. Shariati Hospital. Tehran University of Medical Sciences) ; Aleagha, Afshar Etemadi (Department of Anesthesiology. School of Medicine. Amir Alam Hospital. Tehran University of Medical Sciences) ; Ahmadi, Saeideh (Department of Pulmonology. School of Medicine. Tehran University of Medical Sciences) ; Moghaddam, Seyed Behrooz Mohseni (Department of Pathology. Parseh Pathobiology and Genetics Laboratory) ; Adamsara, Alireza (Department of Microbiology. Health and Family Research Center. NIOC Hospital) ; Saeedi, Morteza (Department of Emergency Medicine. School of Medicine. Shariati Hospital. Tehran University of Medical Sciences) ; Abdollahi, Hamed (Department of Anesthesiology. School of Medicine. Tehran University of Medical Sciences) ; Hosseini, Abdolmajid (Department of Pathology. Faculty of Medicine. Tehran Azad University) ; Chariyavilaskul, Pajaree (Department of Pharmacology. Faculty of Medicine. Chulalongkorn University) ; Chamnanphon, Monpat (Department of Pathology. Faculty of Medicine. Nakornnayok. Srinakharinwirot University) ; Suttichet, Thitima B. (Clinical Pharmacokinetics and Pharmacogenomics Research Unit. Faculty of Medicine. Chulalongkorn University) ; Shotelersuk, Vorasuk (Excellence Center for Genomics and Precision Medicine. King Chulalongkorn Memorial Hospital. The Thai Red Cross Society) ; Pongpanich, Monnat (Omics Sciences and Bioinfomatics Center. Faculty of Science. Chulalongkorn University) ; Phokaew, Chureerat (Faculty of Medicine. Chulalongkorn University) ; Chetruengchai, Wanna (Excellence Center for Genomics and Precision Medicine. King Chulalongkorn Memorial Hospital. The Thai Red Cross Society) ; Jantarabenjakul, Watsamon (Department of Pediatrics. Faculty of Medicine. Chulalongkorn University) ; Putchareon, Opass (Division of Infectious Diseases. Department of Medicine. Faculty of Medicine. Chulalongkorn University) ; Torvorapanit, Pattama (Division of Infectious Diseases. Department of Medicine. Faculty of Medicine. Chulalongkorn University) ; Puthanakit, Thanyawee (Center of Excellence in Pediatric Infectious Diseases and Vaccines. Chulalongkorn University) ; Suchartlikitwong, Pintip (Department of Microbiology. Faculty of Medicine. Chulalongkorn University) ; Hirankarn, Nattiya (Center of Excellence in Immunology and Immune-mediated Diseases. Department of Microbiology. Faculty of Medicine. Chulalongkorn University) ; Nilaratanakul, Voraphoj (Healthcare-associated Infection Research Group STAR (Special Task Force for Activating Research). Chulalongkorn University) ; Sodsai, Pimpayao (Center of Excellence in Immunology and Immune-mediated Diseases. Department of Microbiology. Faculty of Medicine. Chulalongkorn University) ; Brumpton, Ben M. (Clinic of Medicine. St Olav's Hospital. Trondheim University Hospital) ; Hveem, K. (HUNT Research Center. Department of Public Health and Nursing. Norwegian University of Science and Technology (NTNU)) ; Willer, C. (Department of Computational Medicine and Bioinformatics. University of Michigan) ; Zhou, W. (Program in Medical and Population Genetics. Broad Institute of Harvard and MIT) ; Rogne, T. (Clinic of Anaesthesia and Intensive Care. St Olav's Hospital. Trondheim University Hospital) ; Solligard, E. (Clinic of Anaesthesia and Intensive Care. St Olav's Hospital. Trondheim University Hospital) ; Åsvold, Bjørn Olav (Clinic of Medicine. St Olav's Hospital. Trondheim University Hospital) ; Abedalthagafi, M. (Genomics Research Department. Saudi Human Genome Project. King Fahad Medical City. King Abdulaziz City for Science and Technology (KACST)) ; Alaamery, M. (Saudi Human Genome Project (SHGP). King Abdulaziz City for Science and Technology (KACST). Satellite Lab at King Abdulaziz Medical City. Ministry of National Guard Health Affairs) ; Alqahtani, S. (The Division of Gastroenterology and Hepatology. Johns Hopkins University) ; Barakeh, D. (Department of Pathology. College of Medicine. King Saud University) ; Harthi, F.A. (Genomics Research Department. Saudi Human Genome Project. King Fahad Medical City. King Abdulaziz City for Science and Technology (KACST)) ; Alsolm, E. (Genomics Research Department. Saudi Human Genome Project. King Fahad Medical City. King Abdulaziz City for Science and Technology (KACST)) ; Safieh, L.A. (Genomics Research Department. Saudi Human Genome Project. King Fahad Medical City. King Abdulaziz City for Science and Technology (KACST)) ; Alowayn, A.M. (Genomics Research Department. Saudi Human Genome Project. King Fahad Medical City. King Abdulaziz City for Science and Technology (KACST)) ; Alqubaishi, F. (Genomics Research Department. Saudi Human Genome Project. King Fahad Medical City. King Abdulaziz City for Science and Technology (KACST)) ; Mutairi, A.A. (Genomics Research Department. Saudi Human Genome Project. King Fahad Medical City. King Abdulaziz City for Science and Technology (KACST)) ; Mangul, S. (Titus Family Department of Clinical Pharmacy. USC School of Pharmacy. University of Southern California) ; Alshareef, A. (College of Applied Medical Sciences. Taibah University) ; Sawaji, M. (Developmental Medicine Department. King Abdullah International Medical Research Center. King Saud Bin Abdulaziz University for Health Sciences. Ministry of National Guard Health Affairs) ; Almutairi, M. (Saudi Human Genome Project (SHGP). King Abdulaziz City for Science and Technology (KACST). Satellite Lab at King Abdulaziz Medical City. Ministry of National Guard Health Affairs) ; Aljawini, N. (KACST-BWH Centre of Excellence for Biomedicine. Joint Centers of Excellence Program. King Abdulaziz City for Science and Technology (KACST)) ; Albesher, N. (KACST-BWH Centre of Excellence for Biomedicine. Joint Centers of Excellence Program. King Abdulaziz City for Science and Technology (KACST)) ; Arabi, Y.M. (Ministry of the National Guard Health Affairs. King Abdullah International Medical Research Center. King Saud Bin Abdulaziz University for Health Sciences) ; Mahmoud, E.S. (Ministry of the National Guard Health Affairs. King Abdullah International Medical Research Center. King Saud Bin Abdulaziz University for Health Sciences) ; Khattab, A.K. (Ohud Hospital. Ministry of Health) ; Halawani, R.T. (Ohud Hospital. Ministry of Health) ; Alahmadey, Z.Z. (Ohud Hospital. Ministry of Health) ; Albakri, J.K. (Ohud Hospital. Ministry of Health) ; Felemban, W.A. (Ohud Hospital. Ministry of Health) ; Suliman, B.A. (College of Applied Medical Sciences. Taibah University) ; Hasanato, R. (Department of Pathology. College of Medicine. King Saud University) ; Al-Awdah, L. (Pediatric Infectious Diseases,. Children's Specialized Hospital. King Fahad Medical City) ; Alghamdi, J. (The Saudi Biobank. King Abdullah International Medical Research Center. King Saud bin Abdulaziz University for Health Sciences. Ministry of National Guard Health Affairs) ; AlZahrani, D. (Developmental Medicine Department. King Abdullah International Medical Research Center. King Saud Bin Abdulaziz University for Health Sciences. King Abdulaziz Medical City. Ministry of National Guard Health Affairs) ; AlJohani, S. (Department of Pathology and Laboratory Medicine. King Abdulaziz Medical City. Ministry of National Guard Health Affairs. King Saud Bin Abdulaziz University for Health Sciences. King Abdullah International Medical Research Center) ; Al-Afghani, H. (Laboratory Department. Security Forces Hospital. General Directorate of Medical Services. Ministry of Interior) ; Alrashed, M. (Department of Clinical Laboratory Sciences. College of Applied Medical Sciences. King Saud University) ; AlDhawi, N. (Developmental Medicine Department. King Abdullah International Medical Research Center. King Saud Bin Abdulaziz University for Health Sciences. King Abdulaziz Medical City. Ministry of National Guard Health Affairs) ; AlBardis, H. (Genomics Research Department. Saudi Human Genome Project. King Fahad Medical City. King Abdulaziz City for Science and Technology (KACST)) ; Alkwai, S. (KACST-BWH Centre of Excellence for Biomedicine. Joint Centers of Excellence Program. King Abdulaziz City for Science and Technology (KACST)) ; Alswailm, M. (KACST-BWH Centre of Excellence for Biomedicine. Joint Centers of Excellence Program. King Abdulaziz City for Science and Technology (KACST)) ; Almalki, F. (Developmental Medicine Department. King Abdullah International Medical Research Center. King Saud Bin Abdulaziz University for Health Sciences. King Abdulaziz Medical City. Ministry of National Guard Health Affairs) ; Albeladi, M. (Developmental Medicine Department. King Abdullah International Medical Research Center. King Saud Bin Abdulaziz University for Health Sciences. King Abdulaziz Medical City. Ministry of National Guard Health Affairs) ; Almohammed, I. (KACST-BWH Centre of Excellence for Biomedicine. Joint Centers of Excellence Program. King Abdulaziz City for Science and Technology (KACST)) ; Barhoush, E. (King Abdulaziz City for Science and Technology (KACST)) ; Albader, A. (Developmental Medicine Department. King Abdullah International Medical Research Center. King Saud Bin Abdulaziz University for Health Sciences. King Abdulaziz Medical City. Ministry of National Guard Health Affairs) ; Massadeh, S. (Saudi Human Genome Project (SHGP). King Abdulaziz City for Science and Technology (KACST). Satellite Lab at King Abdulaziz Medical City. Ministry of National Guard Health Affairs) ; AlMalik, A. (Life Science and Environmental Institute. King Abdulaziz City for Science and Technology (KACST)) ; Alotaibi, S. (Genomics Research Department. Saudi Human Genome Project. King Fahad Medical City. King Abdulaziz City for Science and Technology (KACST)) ; Alghamdi, B. (Department of Developmental Medicine. King Abdullah International Medical Research Center. King Saud Bin Abdulaziz University for Health Sciences. King Abdulaziz Medical City. Ministry of National Guard Health Affairs) ; Jung, J. (Titus Family Department of Clinical Pharmacy. USC School of Pharmacy. University of Southern California) ; Fawzy, M.S. (Genomics Research Department. Saudi Human Genome Project. King Fahad Medical City. King Abdulaziz City for Science and Technology (KACST)) ; Lee, Y. (Centre for Fertility and Health. Norwegian Institute of Public Health) ; Magnus, P. (Centre for Fertility and Health. Norwegian Institute of Public Health) ; Trogstad, L.I.S. (Department of Method Development and Analytics. Norwegian Institute of Public Health) ; Helgeland, Ø. (Department of Genetics and Bioinformatics. Norwegian Institute of Public Health) ; Harris, J.R. (Department of Genetics and Bioinformatics. Norwegian Institute of Public Health) ; Mangino, M. (NIHR Biomedical Research Centre. Guy's and St Thomas' Foundation Trust) ; Spector, T.D. (Department of Twin Research and Genetic Epidemiology. King's College London) ; Duncan, E. (Department of Twin Research and Genetic Epidemiology. King's College London) ; Smieszek, S.P. (Vanda Pharmaceuticals) ; Przychodzen, B.P. (Vanda Pharmaceuticals) ; Polymeropoulos, C. (Vanda Pharmaceuticals) ; Polymeropoulos, V. (Vanda Pharmaceuticals) ; Polymeropoulos, M.H. (Vanda Pharmaceuticals) ; Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ; Perez-Tur, J. (Neurology and Genetic Mixed Unit. La Fe Health Research Institute) ; Llucià-Carol, Laia (Institut d'Investigació Biomèdica Sant Pau) ; Cullell, Natalia (Institut d'Investigació Biomèdica Sant Pau) ; Muiño, Elena (Institut d'Investigació Biomèdica Sant Pau) ; Cárcel-Márquez, Jara (Institut d'Investigació Biomèdica Sant Pau) ; DeDiego, M.L. (Department of Molecular and Cell Biology. Centro Nacional de Biotecnología (CNB-CSIC). Campus Universidad Autónoma de Madrid) ; Iglesias, L.L. (Instituto de Física de Cantabria (IFCA-CSIC)) ; Planas, A.M. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Soriano, A. (Hospital Clínic i Provincial de Barcelona) ; Rico, V. (Hospital Clínic i Provincial de Barcelona) ; Agüero, D. (Hospital Clínic i Provincial de Barcelona) ; Bedini, J. L. (Hospital Clínic i Provincial de Barcelona) ; Lozano, F. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Domingo, C. (Hospital Clínic i Provincial de Barcelona) ; Robles, V. (Hospital Clínic i Provincial de Barcelona) ; Ruiz-Jaén, F. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Márquez, L. (IIBB-CSIC) ; Gomez, J. (Servicio de Salud del Principado de Asturias) ; Coto, E. (Servicio de Salud del Principado de Asturias) ; Albaiceta, G.M. (Servicio de Salud del Principado de Asturias) ; García-Clemente, M. (Servicio de Salud del Principado de Asturias) ; Dalmau, D. (Hospital Universitari MútuaTerrassa) ; Arranz, M.J. (Hospital Universitari MútuaTerrassa) ; Dietl, Beatriz (Hospital Universitari MútuaTerrassa) ; Serra-Llovich, A. (Hospital Universitari MútuaTerrassa) ; Soler, P. (Hospital Valle Hebrón) ; Colobrán, R. (Hospital Valle Hebrón) ; Martín-Nalda, A. (Hospital Valle Hebrón) ; Martínez, A.P. (Hospital Valle Hebrón) ; Bernardo, D. (Instituto de Biomedicina y Genética Molecular (IBGM). CSIC-Universidad de Valladolid) ; Rojo, S. (Hospital Clínico Universitario de Valladolid (SACYL)) ; Fiz-López, A. (Instituto de Biomedicina y Genética Molecular (IBGM). CSIC-Universidad de Valladolid) ; Arribas, E. (Instituto de Biomedicina y Genética Molecular (IBGM). CSIC-Universidad de Valladolid) ; de la Cal-Sabater, P. (Instituto de Biomedicina y Genética Molecular (IBGM). CSIC-Universidad de Valladolid) ; Segura, T. (Complejo Hospitalario Universitario de Albacete) ; González-Villa, E. (Complejo Hospitalario Universitario de Albacete) ; Serrano-Heras, G. (Complejo Hospitalario Universitario de Albacete) ; Martí-Fàbregas, Joan (Institut d'Investigació Biomèdica Sant Pau) ; Jiménez-Xarrié, Elena (Institut d'Investigació Biomèdica Sant Pau) ; Mimbrera, A.d.F. (Hospital Universitario Ramón y Cajal (Madrid)) ; Masjuan, J. (Hospital Universitario Ramón y Cajal (Madrid)) ; García-Madrona, S. (Hospital Universitario Ramón y Cajal (Madrid)) ; Domínguez-Mayoral, A. (Department of Neurology. Hospital Universitario Virgen Macarena) ; Villalonga, J.M. (Department of Neurology. Hospital Universitario Virgen Macarena) ; Menéndez-Valladares, P. (Department of Neurology. Hospital Universitario Virgen Macarena) ; Chasman, D.I. (Harvard Medical School) ; Buring, Julie E (Harvard Medical School) ; Ridker, P.M. (Harvard Medical School) ; Franco, G. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ; Sesso, H.D. (Harvard Medical School) ; Manson, J.A.E. (Harvard Medical School) ; Glessner, J.R. (Division of Human Genetics. Department of Pediatrics. The Perelman School of Medicine. University of Pennsylvania) ; Hakonarson, H. (Faculty of Medicine. University of Iceland) ; Medina-Gomez, C. (Erasmus MC) ; Uitterlinden, A.G. (Erasmus MC) ; Ikram, M.A. (Erasmus MC) ; Kristiansson, K. (Finnish Institute for Health and Welfare (THL)) ; Koskelainen, S. (Finnish Institute for Health and Welfare (THL)) ; Perola, M. (University of Helsinki. Faculty of Medicine. Clinical and Molecular Metabolism Research Program) ; Donner, K. (Institute for Molecular Medicine Finland (FIMM). University of Helsinki) ; Kivinen, K. (Institute for Molecular Medicine Finland (FIMM). University of Helsinki) ; Palotie, A. (Institute for Molecular Medicine Finland (FIMM). University of Helsinki) ; Ripatti, S. (Faculty of Medicine. University of Helsinki) ; Ruotsalainen, S. (Institute for Molecular Medicine Finland (FIMM). University of Helsinki) ; Kaunisto, M. (Institute for Molecular Medicine Finland (FIMM). University of Helsinki) ; Nakanishi, T. (Japan Society for the Promotion of Science) ; Butler-Laporte, G. (Lady Davis Institute. Jewish General Hospital. McGill University) ; Forgetta, V. (Department of Human Genetics. McGill University) ; Morrison, D.R. (Department of Human Genetics. McGill University) ; Ghosh, B. (Department of Human Genetics. McGill University) ; Laurent, L. (Department of Human Genetics. McGill University) ; Belisle, A. (Department of Human Genetics. McGill University) ; Henry, D. (Department of Human Genetics. McGill University) ; Abdullah, T. (Department of Human Genetics. McGill University) ; Adeleye, O. (Department of Human Genetics. McGill University) ; Mamlouk, N. (Department of Human Genetics. McGill University) ; Kimchi, N. (Department of Human Genetics. McGill University) ; Afrasiabi, Z. (Department of Human Genetics. McGill University) ; Rezk, N. (Department of Human Genetics. McGill University) ; Vulesevic, B. (Department of Human Genetics. McGill University) ; Bouab, M. (Department of Human Genetics. McGill University) ; Guzman, C. (Department of Human Genetics. McGill University) ; Petitjean, L. (Department of Human Genetics. McGill University) ; Tselios, C. (Department of Human Genetics. McGill University) ; Xue, X. (Department of Human Genetics. McGill University) ; Schurr, E. (Department of Human Genetics. McGill University) ; Afilalo, J. (Department of Human Genetics. McGill University) ; Afilalo, M. (Department of Human Genetics. McGill University) ; Oliveira, M. (Department of Human Genetics. McGill University) ; Brenner, B. (Department of Human Genetics. McGill University) ; Lepage, P. (Department of Human Genetics. McGill University) ; Ragoussis, J. (Department of Human Genetics. McGill University) ; Auld, D. (Department of Human Genetics. McGill University) ; Brassard, N. (Department of Human Genetics. McGill University) ; Durand, M. (Department of Human Genetics. McGill University) ; Chassé, M. (Department of Human Genetics. McGill University) ; Kaufmann, D.E. (Department of Human Genetics. McGill University) ; Lathrop, G.M. (Department of Human Genetics. McGill University) ; Mooser, V. (Department of Human Genetics. McGill University) ; Richards, J.B. (Department of Human Genetics. McGill University) ; Li, R. (Department of Human Genetics. McGill University) ; Adra, D. (Department of Human Genetics. McGill University) ; Rahmouni, S. (University of Liege) ; Georges, M. (University of Liege) ; Moutschen, M. (CHU of Liege) ; Misset, B. (CHU of Liege) ; Darcis, G. (CHU of Liege) ; Guiot, J. (CHU of Liege) ; Guntz, J. (CHU of Liege) ; Azarzar, S. (CHU of Liege) ; Gofflot, S. (5BHUL (Liege Biobank). CHU of Liege) ; Beguin, Y. (5BHUL (Liege Biobank). CHU of Liege) ; Claassen, S. (CHC Mont-Legia) ; Malaise, O. (CHU of Liege) ; Huynen, P. (CHU of Liege) ; Meuris, C. (CHU of Liege) ; Thys, M. (CHU of Liege) ; Jacques, J. (CHU of Liege) ; Léonar, P. (CHU of Liege) ; Frippiat, F. (CHU of Liege) ; Giot, J.B. (CHU of Liege) ; Sauvage, A.S. (CHU of Liege) ; von Frenckell, C. (CHU of Liege) ; Belhaj, Y. (University of Liege) ; Lambermont, B. (CHU of Liege) ; Pigazzini, S. (Institute for Molecular Medicine Finland (FIMM). University of Helsinki) ; Daya, M. (University of Colorado) ; Shortt, J. (University of Colorado) ; Rafaels, N. (University of Colorado) ; Wicks, S.J. (University of Colorado) ; Crooks, K. (University of Colorado) ; Barnes, K.C. (University of Colorado) ; Gignoux, C.R. (University of Colorado) ; Chavan, S. (University of Colorado) ; Laisk, T. (Estonian Genome Centre. Institute of Genomics. University of Tartu) ; Läll, K. (Estonian Genome Centre. Institute of Genomics. University of Tartu) ; Lepamets, M. (Estonian Genome Centre. Institute of Genomics. University of Tartu) ; Mägi, R. (Estonian Genome Centre. Institute of Genomics. University of Tartu) ; Esko, T. (Estonian Genome Centre. Institute of Genomics. University of Tartu) ; Reimann, E. (Estonian Genome Centre. Institute of Genomics. University of Tartu) ; Milani, L. (Estonian Genome Centre. Institute of Genomics. University of Tartu) ; Alavere, H. (Estonian Genome Centre. Institute of Genomics. University of Tartu) ; Metsalu, K. (Estonian Genome Centre. Institute of Genomics. University of Tartu) ; Puusepp, M. (Estonian Genome Centre. Institute of Genomics. University of Tartu) ; Metspalu, A. (Estonian Genome Centre. Institute of Genomics. University of Tartu) ; Naaber, P. (University of Tartu) ; Laane, E. (Tartu University Hospital (Tartu, Estònia)) ; Pesukova, J. (Kuressaare Hospital) ; Peterson, P. (Institute of Biomedicine and Translational Medicine. University of Tartu) ; Kisand, K. (Institute of Biomedicine and Translational Medicine. University of Tartu) ; Tabri, J. (West Tallinn Central Hospital) ; Allos, R. (West Tallinn Central Hospital) ; Hensen, K. (West Tallinn Central Hospital) ; Starkopf, J. (Tartu University Hospital (Tartu, Estònia)) ; Ringmets, I. (Estonian Health Insurance Fund) ; Tamm, A. (Tartu University Hospital (Tartu, Estònia)) ; Kallaste, A. (Tartu University Hospital (Tartu, Estònia)) ; Bochud, P.Y. (Infectious Diseases Service. Department of Medicine. University Hospital. University of Lausanne) ; Rivolta, C. (Department of Ophthalmology. University of Basel) ; Bibert, S. (Infectious Diseases Service. Department of Medicine. University Hospital. University of Lausanne) ; Quinodoz, M. (Department of Ophthalmology. University of Basel) ; Kamdar, D. (Department of Ophthalmology. University of Basel) ; Boillat, N. (Infectious Diseases Service. Department of Medicine. University Hospital. University of Lausanne) ; Nussle, S.G. (Centre for Primary Care and Public Health. University of Lausanne) ; Albrich, W. (Division of Infectious Diseases and Hospital Epidemiology. Cantonal Hospital St Gallen) ; Suh, N. (Division of Intensive Care. Geneva University Hospitals. University of Geneva. Faculty of Medicine) ; Neofytos, D. (Infectious Disease Service. Department of Internal Medicine. Geneva University Hospital) ; Erard, V. (Clinique de Médecine et Spécialités. Infectiologie. HFR-Fribourg) ; Voide, C. (Infectious Diseases Division. University Hospital Centre of the canton of Vaud. Hospital of Valais) ; de Cid, R. (Institut Germans Trias i Pujol) ; Galván-Femenía, I. (Institut Germans Trias i Pujol) ; Blay, Natalia (Institut Germans Trias i Pujol) ; Carreras, A. (Institut Germans Trias i Pujol) ; Cortés, B. (Institut Germans Trias i Pujol) ; Farré, X. (Institut Germans Trias i Pujol) ; Sumoy, L. (Institut Germans Trias i Pujol) ; Moreno, V. (Catalan Institute of Oncology. Bellvitge Biomedical Research Institute. Consortium for Biomedical Research in Epidemiology and Public Health. University of Barcelona) ; Mercader, J.M. (Massachusetts General Hospital) ; Guindo-Martinez, M. (Barcelona Supercomputing Center-Centro Nacional de Supercomputación (BSC-CNS)) ; Torrents, D. (Barcelona Supercomputing Center-Centro Nacional de Supercomputación (BSC-CNS)) ; Kogevinas, M. (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ; Garcia-Aymerich, Judith (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ; Castaño-Vinyals, G. (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ; Dobaño, C. (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ; Renieri, A. (Med Biotech Hub and Competence Center. Department of Medical Biotechnologies. University of Siena) ; Mari, F. (Med Biotech Hub and Competence Center. Department of Medical Biotechnologies. University of Siena) ; Fallerini, C. (Med Biotech Hub and Competence Center. Department of Medical Biotechnologies. University of Siena) ; Daga, S. (Med Biotech Hub and Competence Center. Department of Medical Biotechnologies. University of Siena) ; Benetti, E. (Med Biotech Hub and Competence Center. Department of Medical Biotechnologies. University of Siena) ; Baldassarri, M. (Med Biotech Hub and Competence Center. Department of Medical Biotechnologies. University of Siena) ; Fava, F. (Med Biotech Hub and Competence Center. Department of Medical Biotechnologies. University of Siena) ; Frullanti, E. (Med Biotech Hub and Competence Center. Department of Medical Biotechnologies. University of Siena) ; Valentino, F. (Med Biotech Hub and Competence Center. Department of Medical Biotechnologies. University of Siena) ; Doddato, G. (Med Biotech Hub and Competence Center. Department of Medical Biotechnologies. University of Siena) ; Giliberti, A. (Med Biotech Hub and Competence Center. Department of Medical Biotechnologies. University of Siena) ; Tita, R. (Azienda Ospedaliero-Universitaria Senese) ; Amitrano, S. (Azienda Ospedaliero-Universitaria Senese) ; Bruttini, M. (Med Biotech Hub and Competence Center. Department of Medical Biotechnologies. University of Siena) ; Croci, S. (Med Biotech Hub and Competence Center. Department of Medical Biotechnologies. University of Siena) ; Meloni, I. (Med Biotech Hub and Competence Center. Department of Medical Biotechnologies. University of Siena) ; Mencarelli, M.A. (Azienda Ospedaliero-Universitaria Senese) ; Rizzo, C.L. (Azienda Ospedaliero-Universitaria Senese) ; Pinto, A.M. (Azienda Ospedaliero-Universitaria Senese) ; Beligni, G. (Med Biotech Hub and Competence Center. Department of Medical Biotechnologies. University of Siena) ; Tommasi, A. (Infectious Diseases Clinic. Department of Medicine 2. Azienda Ospedaliera di Perugia and University of Perugia. Santa Maria Hospital) ; Sarno, L.D. (Med Biotech Hub and Competence Center. Department of Medical Biotechnologies. University of Siena) ; Palmieri, M. (Med Biotech Hub and Competence Center. Department of Medical Biotechnologies. University of Siena) ; Carriero, M.L. (Med Biotech Hub and Competence Center. Department of Medical Biotechnologies. University of Siena) ; Alaverdian, D. (Med Biotech Hub and Competence Center. Department of Medical Biotechnologies. University of Siena) ; Busani, S. (Department of Anesthesia and Intensive Care. University of Modena and Reggio Emilia) ; Bruno, Raffaele (Department of Internal Medicine and Therapeutics. University of Pavia) ; Vecchia, M. (Division of Infectious Diseases and Immunology. Fondazione IRCCS Policlinico San Matteo) ; Belli, M.A. (U.O.C. Medicina. ASST Nord Milano. Ospedale Bassini) ; Picchiotti, N. (University of Siena. DIISM-SAILAB) ; Sanarico, M. ; Gori, M. (University of Siena. DIISM-SAILAB) ; Furini, S. (Med Biotech Hub and Competence Center. Department of Medical Biotechnologies. University of Siena) ; Mantovani, S. (Division of Infectious Diseases and Immunology. Fondazione IRCCS Policlinico San Matteo) ; Ludovisi, S. (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico) ; Mondelli, M.U. (Department of Internal Medicine and Therapeutics. University of Pavia) ; Castelli, F. (Department of Infectious and Tropical Diseases. University of Brescia and ASST Spedali Civili Hospital) ; Quiros-Roldan, E. (Department of Infectious and Tropical Diseases. University of Brescia and ASST Spedali Civili Hospital) ; Antoni, M.D. (Department of Infectious and Tropical Diseases. University of Brescia and ASST Spedali Civili Hospital) ; Zanella, I. (Clinical Chemistry Laboratory. Cytogenetics and Molecular Genetics Section. Diagnostic Department. ASST Spedali Civili di Brescia) ; Vaghi, M. (Chirurgia Vascolare. Ospedale Maggiore di Crema) ; Rusconi, S. (Department of Biomedical and Clinical Sciences Luigi Sacco. University of Milan) ; Siano, M. (Department of Biomedical and Clinical Sciences Luigi Sacco. University of Milan) ; Montagnani, F. (Department of Specialized and Internal Medicine. Tropical and Infectious Diseases Unit. Azienda Ospedaliera Universitaria Senese) ; Emiliozzi, A. (HIV/AIDS Department. National Institute for Infectious Diseases Lazzaro Spallanzani. IRCCS) ; Fabbiani, M. (Department of Specialized and Internal Medicine. Tropical and Infectious Diseases Unit. Azienda Ospedaliera Universitaria Senese) ; Rossetti, B. (Department of Specialized and Internal Medicine. Tropical and Infectious Diseases Unit. Azienda Ospedaliera Universitaria Senese) ; Bargagli, E. (Unit of Respiratory Diseases and Lung Transplantation. Department of Internal and Specialist Medicine. University of Siena) ; Bergantini, L. (Unit of Respiratory Diseases and Lung Transplantation. Department of Internal and Specialist Medicine. University of Siena) ; D'Alessandro, M. (Unit of Respiratory Diseases and Lung Transplantation. Department of Internal and Specialist Medicine. University of Siena) ; Cameli, P. (Unit of Respiratory Diseases and Lung Transplantation. Department of Internal and Specialist Medicine. University of Siena) ; Bennett, D. (Unit of Respiratory Diseases and Lung Transplantation. Department of Internal and Specialist Medicine. University of Siena) ; Anedda, F. (Unit of Intensive Care Medicine. Departments of Emergency and Urgency. Medicine. Surgery and Neurosciences. Siena University Hospital) ; Marcantonio, S. (Unit of Intensive Care Medicine. Departments of Emergency and Urgency. Medicine. Surgery and Neurosciences. Siena University Hospital) ; Scolletta, S. (Unit of Intensive Care Medicine. Departments of Emergency and Urgency. Medicine. Surgery and Neurosciences. Siena University Hospital) ; Franchi, F. (Unit of Intensive Care Medicine. Departments of Emergency and Urgency. Medicine. Surgery and Neurosciences. Siena University Hospital) ; Mazzei, M.A. (Unit of Diagnostic Imaging. Departments of Medical. Surgical and Neurosciences and Radiological Sciences. University of Siena) ; Guerrini, S. (Unit of Diagnostic Imaging. Departments of Medical. Surgical and Neurosciences and Radiological Sciences. University of Siena) ; Conticini, E. (Rheumatology Unit. Department of Medicine. Surgery and Neurosciences. University of Siena. Policlinico Le Scotte) ; Cantarini, L. (Rheumatology Unit. Department of Medicine. Surgery and Neurosciences. University of Siena. Policlinico Le Scotte) ; Frediani, B. (Rheumatology Unit. Department of Medicine. Surgery and Neurosciences. University of Siena. Policlinico Le Scotte) ; Tacconi, D. (Infectious Diseases Unit. Department of Specialized and Internal Medicine. San Donato Hospital Arezzo) ; Spertilli, C. (Infectious Diseases Unit. Department of Specialized and Internal Medicine. San Donato Hospital Arezzo) ; Feri, M. (Anesthesia Unit. Department of Emergency. San Donato Hospital) ; Donati, A. (Anesthesia Unit. Department of Emergency. San Donato Hospital) ; Scala, R. (Pneumology Unit and UTIP. Department of Specialized and Internal Medicine. San Donato Hospital) ; Guidelli, L. (Pneumology Unit and UTIP. Department of Specialized and Internal Medicine. San Donato Hospital) ; Spargi, G. (Anesthesia Unit. Department of Emergency. Misericordia Hospital) ; Corridi, M. (Anesthesia Unit. Department of Emergency. Misericordia Hospital) ; Nencioni, C. (Infectious Diseases Unit. Department of Specialized and Internal Medicine. Misericordia Hospital) ; Croci, L. (Infectious Diseases Unit. Department of Specialized and Internal Medicine. Misericordia Hospital) ; Bandini, M. (Department of Preventive Medicine. Azienda USL Toscana Sud Est) ; Caldarelli, G.P. (Clinical Chemical Analysis Laboratory. Misericordia Hospital) ; Piacentini, P. (Department of Preventive Medicine. Azienda USL Toscana Sud Est) ; Desanctis, E. (Department of Preventive Medicine. Azienda USL Toscana Sud Est) ; Cappelli, S. (Department of Preventive Medicine. Azienda USL Toscana Sud Est) ; Canaccini, A. (Territorial Scientific Technician Department. Azienda USL Toscana Sud Est) ; Verzuri, A. (Territorial Scientific Technician Department. Azienda USL Toscana Sud Est) ; Anemoli, V. (Territorial Scientific Technician Department. Azienda USL Toscana Sud Est) ; Ognibene, A. (Clinical Chemical Analysis Laboratory. San Donato Hospital) ; Pancrazzi, A. (Clinical Chemical Analysis Laboratory. San Donato Hospital) ; Lorubbio, M. (Clinical Chemical Analysis Laboratory. San Donato Hospital) ; Monforte, A.D. (Department of Health Sciences. Clinic of Infectious Diseases. ASST Santi Paolo e Carlo. University of Milan) ; Miraglia, F.G. (Department of Health Sciences. Clinic of Infectious Diseases. ASST Santi Paolo e Carlo. University of Milan) ; Girardis, M. (Department of Anesthesia and Intensive Care. University of Modena and Reggio Emilia) ; Venturelli, S. (Department of Anesthesia and Intensive Care. University of Modena and Reggio Emilia) ; Cossarizza, A. (Department of Medical and Surgical Sciences for Children and Adults. University of Modena and Reggio Emilia) ; Antinori, A. (HIV/AIDS Department. National Institute for Infectious Diseases Lazzaro Spallanzani. IRCCS) ; Vergori, A. (HIV/AIDS Department. National Institute for Infectious Diseases Lazzaro Spallanzani. IRCCS) ; Gabrieli, A. (Department of Biomedical and Clinical Sciences Luigi Sacco. University of Milan) ; Riva, A. (Department of Biomedical and Clinical Sciences Luigi Sacco. University of Milan) ; Francisci, D. (Infectious Diseases Clinic. Santa Maria Hospital. University of Perugia) ; Schiaroli, E. (Infectious Diseases Clinic. Santa Maria Hospital. University of Perugia) ; Paciosi, F. (Infectious Diseases Clinic. Santa Maria Hospital. University of Perugia) ; Scotton, P.G. (Department of Infectious Diseases. Treviso Hospital) ; Andretta, F. (Department of Infectious Diseases. Treviso Hospital) ; Panese, S. (Clinical Infectious Diseases. Mestre Hospital) ; Scaggiante, R. (Infectious Diseases Clinic) ; Gatti, F. (Infectious Diseases Clinic) ; Parisi, S.G. (Department of Molecular Medicine. University of Padova) ; Baratti, S. (Department of Molecular Medicine. University of Padova) ; Monica, M.D. (Medical Genetics and Laboratory of Medical Genetics Unit. A.O.R.N. Antonio Cardarelli Hospital) ; Piscopo, C. (Medical Genetics and Laboratory of Medical Genetics Unit. A.O.R.N. Antonio Cardarelli Hospital) ; Capasso, M. (IRCCS SDN) ; Russo, R. (CEINGE Biotecnologie Avanzate) ; Andolfo, I. (CEINGE Biotecnologie Avanzate) ; Iolascon, A. (CEINGE Biotecnologie Avanzate) ; Fiorentino, G. (Unit of Respiratory Physiopathology. AORN dei Colli. Monaldi Hospital) ; Carella, M. (Division of Medical Genetics. Fondazione IRCCS Casa Sollievo della Sofferenza Hospital) ; Castori, M. (Division of Medical Genetics. Fondazione IRCCS Casa Sollievo della Sofferenza Hospital) ; Merla, G. (Laboratory of Regulatory and Functional Genomics. Fondazione IRCCS Casa Sollievo della Sofferenza Hospital) ; Squeo, G.M. (Laboratory of Regulatory and Functional Genomics. Fondazione IRCCS Casa Sollievo della Sofferenza Hospital) ; Aucella, F. (Department of Medical Sciences. Fondazione IRCCS Casa Sollievo della Sofferenza Hospital) ; Raggi, P. (Clinical Trial Office. Fondazione IRCCS Casa Sollievo della Sofferenza Hospital) ; Marciano, C. (Clinical Trial Office. Fondazione IRCCS Casa Sollievo della Sofferenza Hospital) ; Perna, R. (Clinical Trial Office. Fondazione IRCCS Casa Sollievo della Sofferenza Hospital) ; Bassetti, M. (Infectious Diseases Clinic. Policlinico San Martino Hospital. IRCCS for Cancer Research) ; Biagio, A.D. (Infectious Diseases Clinic. Policlinico San Martino Hospital. IRCCS for Cancer Research) ; Sanguinetti, M. (Department of Laboratory Sciences and Infectious Diseases. Fondazione Policlinico Universitario A. Gemelli IRCCS) ; Masucci, L. (Department of Laboratory Sciences and Infectious Diseases. Fondazione Policlinico Universitario A. Gemelli IRCCS) ; Valente, S. (Department of Cardiovascular Diseases. University of Siena) ; Mandalà, M. (Otolaryngology Unit. University of Siena) ; Giorli, A. (Otolaryngology Unit. University of Siena) ; Salerni, L. (Otolaryngology Unit. University of Siena) ; Zucchi, P. (Department of Internal Medicine. ASST Valtellina e Alto Lario) ; Parravicini, P. (Department of Internal Medicine. ASST Valtellina e Alto Lario) ; Menatti, E. (Oncologia Medica e Ufficio Flussi Sondrio) ; Trotta, T. (First Aid Department. Luigi Curto Hospital) ; Giannattasio, F. (First Aid Department. Luigi Curto Hospital) ; Coiro, G. (First Aid Department. Luigi Curto Hospital) ; Lena, F. (Local Health Unit. Pharmaceutical Department of Grosseto. Toscana Sud Est Local Health Unit) ; Coviello, D.A. (U.O.C. Laboratorio di Genetica Umana. IRCCS Istituto Giannina Gaslini) ; Mussini, C. (Infectious Diseases Clinics. University of Modena and Reggio Emilia) ; Martinelli, E. (Department of Respiratory Diseases. Azienda Ospedaliera di Cremona) ; Mancarella, S. (U.O.C. Medicina. ASST Nord Milano. Ospedale Bassini) ; Tavecchia, L. (U.O.C. Medicina. ASST Nord Milano. Ospedale Bassini) ; Crotti, L. (Laboratory of Cardiovascular Genetics. Istituto Auxologico Italiano. IRCCS) ; Gabbi, C. ; Rizzi, M. (Unit of Infectious Diseases. ASST Papa Giovanni XXIII Hospital) ; Maggiolo, F. (Unit of Infectious Diseases. ASST Papa Giovanni XXIII Hospital) ; Ripamonti, D. (Unit of Infectious Diseases. ASST Papa Giovanni XXIII Hospital) ; Bachetti, T. (Direzione Scientifica. Istituti Clinici Scientifici Maugeri IRCCS) ; Rovere, M.T.L. (Department of Cardiology. Istituti Clinici Scientifici Maugeri IRCCS. Institute of Montescano) ; Sarzi-Braga, S. (Department of Cardiac Rehabilitation. Institute of Tradate (VA) and Istituti Clinici Scientifici Maugeri IRCCS) ; Bussotti, M. (Department of Cardiology. Istituti Clinici Scientifici Maugeri IRCCS. Institute of Milan) ; Ceri, S. (Department of Electronics. Information and Bioengineering (DEIB). Politecnico di Milano) ; Pinoli, P. (Department of Electronics. Information and Bioengineering (DEIB). Politecnico di Milano) ; Raimondi, F. (Scuola Normale Superiore (Pisa, Itàlia)) ; Biscarini, F. (CNR-Consiglio Nazionale delle Ricerche. Istituto di Biologia e Biotecnologia Agraria (IBBA)) ; Stella, A. (CNR-Consiglio Nazionale delle Ricerche. Istituto di Biologia e Biotecnologia Agraria (IBBA)) ; Zguro, K. (Med Biotech Hub and Competence Center. Department of Medical Biotechnologies. University of Siena) ; Capitani, K. (Core Research Laboratory. ISPRO) ; Suardi, C. (Fondazione per la Ricerca Ospedale di Bergamo) ; Dei, S. (Azienda USL Toscana Sud Est) ; Parati, G. (Department of Medicine and Surgery. University of Milano-Bicocca) ; Ravaglia, S. (IRCCS Mondino Foundation) ; Artuso, R. (Medical Genetics Unit. Meyer Children's University Hospital) ; Bottà, G. (Allelica) ; Di Domenico, P. (Allelica) ; Rancan, I. (Department of Specialized and Internal Medicine. Tropical and Infectious Diseases Unit. Azienda Ospedaliera Universitaria Senese) ; Perrella, A. (Pneumology Unit. Department of Medicine. Misericordia Hospital) ; Bianchi, F. (Pneumology Unit. Department of Medicine. Misericordia Hospital) ; Romani, D. (Department of Preventive Medicine. Azienda USL Toscana Sud Est) ; Bergomi, P. (Intensive Care Unit and Department of Anesthesia. ASST Fatebenefratelli Sacco. Luigi Sacco Hospital. Polo Universitario. University of Milan) ; Catena, E. (Intensive Care Unit and Department of Anesthesia. ASST Fatebenefratelli Sacco. Luigi Sacco Hospital. Polo Universitario. University of Milan) ; Colombo, R. (Intensive Care Unit and Department of Anesthesia. ASST Fatebenefratelli Sacco. Luigi Sacco Hospital. Polo Universitario. University of Milan) ; Tanfoni, M. (University of Siena. DIISM-SAILAB) ; Vincenti, A. (Infectious Disease Unit. Hospital of Massa) ; Ferri, C. (Department of Clinical Medicine. Public Health. Life and Environment Sciences. University of L'Aquila) ; Grassi, D. (Department of Clinical Medicine. Public Health. Life and Environment Sciences. University of L'Aquila) ; Pessina, G. (UOSD Laboratorio di Genetica Medica-ASL Viterbo) ; Tumbarello, M. (Department of Medical Sciences. Infectious and Tropical Diseases Unit. Azienda Ospedaliera Universitaria Senese) ; Di Pietro, M. (Unit of Infectious Diseases. Santa Maria Annunziata Hospital) ; Sabrina, R. (IRCCS Mondino Foundation) ; Luchi, S. (Infectious Disease Unit. Hospital of Lucca) ; Barbieri, C. (Infectious Diseases Unit. Department of Clinical and Experimental Medicine. University of Pisa) ; Acquilini, D. (Infectious Disease Unit. Santo Stefano Hospital. AUSL Toscana Centro) ; Andreucci, E. (Medical Genetics Unit. Meyer Children's University Hospital) ; Segala, F.V. (Clinic of Infectious Diseases. Catholic University of the Sacred Heart) ; Tiseo, G. (Infectious Diseases Unit. Department of Clinical and Experimental Medicine. University of Pisa) ; Falcone, M. (Infectious Diseases Unit. Department of Clinical and Experimental Medicine. University of Pisa) ; Lista, M. (Med Biotech Hub and Competence Center. Department of Medical Biotechnologies. University of Siena) ; Poscente, M. (UOSD Laboratorio di Genetica Medica-ASL Viterbo) ; De Vivo, O. (Department of Cardiovascular Diseases. University of Siena) ; Petrocelli, P. (Infectious Disease Unit. Hospital of Lucca) ; Guarnaccia, A. (Fondazione Policlinico Universitario Agostino Gemelli IRCCS. Catholic University of Medicine) ; Baroni, S. (Department of Diagnostic and Laboratory Medicine. Institute of Biochemistry and Clinical Biochemistry. Fondazione Policlinico Universitario A. Gemelli IRCCS. Catholic University of the Sacred Heart) ; Smith, A.V. (University of Michigan) ; Boughton, A.P. (University of Michigan) ; Li, K.W. (University of Michigan) ; LeFaive, J. (University of Michigan) ; Annis, A. (University of Michigan) ; Chittoor, G. (Department of Population Health Sciences. Geisinger Health System) ; Josyula, N.S. (Department of Population Health Sciences. Geisinger Health System) ; Leader, J.B. (Phenomic Analytics and Clinical Data Core. Geisinger Health System) ; Carey, D.J. (Department of Molecular and Functional Genomics. Geisinger Health System) ; Gass, M.C. (Phenomic Analytics and Clinical Data Core. Geisinger Health System) ; Cantor, M.N. (Regeneron Genetics Center) ; Yadav, A. (Regeneron Genetics Center) ; van Heel, D.A. (Queen Mary University of London) ; Hunt, K.A. (Queen Mary University of London) ; Mason, D. (Bradford Institute for Health Research. Bradford Teaching Hospitals National Health Service (NHS) Foundation Trust) ; Huang, Q.Q. (Wellcome Trust Sanger Institute (Regne Unit)) ; Finer, S. (Queen Mary University of London) ; Trivedi, B. (Queen Mary University of London) ; Griffiths, C.J. (Queen Mary University of London) ; Martin, H.C. (Wellcome Trust Sanger Institute (Regne Unit)) ; Wright, J. (Bradford Institute for Health Research. Bradford Teaching Hospitals National Health Service (NHS) Foundation Trust) ; Trembath, R.C. (School of Basic and Medical Biosciences. Faculty of Life Sciences and Medicine. King's College London) ; Soranzo, N. (Department of Haematology. University of Cambridge) ; Zhao, J.H. (British Heart Foundation Cardiovascular Epidemiology Unit. Department of Public Health and Primary Care. University of Cambridge) ; Butterworth, A.S. (Health Data Research UK Cambridge. University of Cambridge) ; Danesh, J. (Health Data Research UK Cambridge. University of Cambridge) ; Di Angelantonio, Emanuele (Health Data Research UK Cambridge. University of Cambridge) ; Franke, L. (Department of Genetics. University Medical Centre Groningen. University of Groningen) ; Boezen, M. (Department of Genetics. University Medical Centre Groningen. University of Groningen) ; Deelen, P. (Department of Genetics. University Medical Centre Utrecht) ; Claringbould, A. (Department of Genetics. University Medical Centre Groningen. University of Groningen) ; Lopera, E. (Department of Genetics. University Medical Centre Groningen. University of Groningen) ; Warmerdam, R. (Department of Genetics. University Medical Centre Groningen. University of Groningen) ; Vonk, J.M. (Department of Epidemiology. University Medical Center Groningen. University of Groningen) ; van Blokland, I. (Department of Genetics. University Medical Centre Groningen. University of Groningen) ; Lanting, P. (Department of Genetics. University Medical Centre Groningen. University of Groningen) ; Ori, A.P.S. (Department of Psychiatry. University Medical Center Groningen) ; Zöllner, S. (University of Michigan) ; Wang, J. (University of Michigan) ; Beck, A. (University of Michigan) ; Peloso, G. (Center for Population Genomics. MAVERIC. VA Boston Healthcare System) ; Ho, Y.L. (MAVERIC. VA Boston Healthcare System) ; Sun, Y.V. (Department of Epidemiology. Emory University Rollins School of Public Health) ; Huffman, J.E. (Center for Population Genomics. MAVERIC. VA Boston Healthcare System) ; O'Donnell, C.J. (Center for Population Genomics. MAVERIC. VA Boston Healthcare System) ; Cho, K. (MAVERIC. VA Boston Healthcare System) ; Tsao, P. (Stanford University) ; Gaziano, J.M. (MAVERIC. VA Boston Healthcare System) ; Nivard, M. (Vrije Universiteit Amsterdam) ; de Geus, E. (Vrije Universiteit Amsterdam) ; Bartels, M. (Vrije Universiteit Amsterdam) ; Hottenga, J.J. (Vrije Universiteit Amsterdam) ; Weiss, S.T. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ; Karlson, E.W. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ; Smoller, J.W. (Massachusetts General Hospital) ; Green, R.C. (Broad Institute of MIT and Harvard) ; Feng, Y.C.A. (Massachusetts General Hospital) ; Mercader, J. (Broad Institute of MIT and Harvard) ; Murphy, S.N. (Massachusetts General Hospital) ; Meigs, J.B. (Massachusetts General Hospital) ; Woolley, A.E. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ; Perez, E.F. (Massachusetts General Hospital) ; Rader, D. (Department of Genetics. University of Pennsylvania Perelman School of Medicine) ; Li, B. (Stanford University) ; Verma, S.S. (Department of Genetics. University of Pennsylvania Perelman School of Medicine) ; Lucas, A. (Department of Genetics. University of Pennsylvania Perelman School of Medicine) ; Bradford, Y. (Department of Genetics. University of Pennsylvania Perelman School of Medicine) ; Zeberg, H. (Max Planck Institute for Evolutionary Anthropology) ; Frithiof, R. (Department of Surgical Sciences. Uppsala University) ; Hultström, M. (Department of Medical Cell Biology. Uppsala University) ; Lipcsey, M. (Department of Surgical Sciences. Uppsala University) ; Nkambul, L. (Stanley Center for Psychiatric Research and Program in Medical and Population Genetics) ; Tardif, N. (Division Anesthesiology and Intensive Care. CLINTEC. Karolinska Institutet) ; Rooyackers, O. (Division Anesthesiology and Intensive Care. CLINTEC. Karolinska Institutet) ; Grip, J. (Division Anesthesiology and Intensive Care. CLINTEC. Karolinska Institutet) ; Maricic, T. (Max Planck Institute for Evolutionary Anthropology) ; Karczewski, K.J. (Massachusetts General Hospital) ; Atkinson, E.G. (Massachusetts General Hospital) ; Tsuo, K. (Massachusetts General Hospital) ; Baya, N. (Massachusetts General Hospital) ; Turley, P. (Massachusetts General Hospital) ; Gupta, R. (Massachusetts General Hospital) ; Callier, S. (Department of Clinical Research and Leadership. George Washington University) ; Walters, R.K. (Massachusetts General Hospital) ; Palmer, D.S. (Massachusetts General Hospital) ; Sarma, G. (Massachusetts General Hospital) ; Cheng, N. (Massachusetts General Hospital) ; Lu, W. (Massachusetts General Hospital) ; Bryant, S. (Massachusetts General Hospital) ; Churchhouse, C. (Massachusetts General Hospital) ; Cusick, C. (Broad Institute of MIT and Harvard) ; Goldstein, J.I. (Massachusetts General Hospital) ; King, D. (Massachusetts General Hospital) ; Seed, C. (Massachusetts General Hospital) ; Finucane, H. (Massachusetts General Hospital) ; Martin, A.R. (Massachusetts General Hospital) ; Satterstrom, F.K. (Massachusetts General Hospital) ; Wilson, D.J. (Big Data Institute. Nuffield Department of Population Health. University of Oxford) ; Armstrong, J. (Big Data Institute. Nuffield Department of Population Health. University of Oxford) ; Rudkin, J.K. (Big Data Institute. Nuffield Department of Population Health. University of Oxford) ; Band, G. (Wellcome Centre for Human Genetics. University of Oxford) ; Earle, S.G. (Big Data Institute. Nuffield Department of Population Health. University of Oxford) ; Lin, S.K. (Big Data Institute. Nuffield Department of Population Health. University of Oxford) ; Arning, N. (Big Data Institute. Nuffield Department of Population Health. University of Oxford) ; Crook, D.W. (Nuffield Department of Medicine. Experimental Medicine Division. University of Oxford. John Radcliffe Hospital) ; Wyllie, D.H. (Public Health England. Field Service. Addenbrooke's Hospital) ; O'Connell, A.M. (Public Health England. Data and Analytical Services. National Infection Service) ; Spencer, C.C.A. (Genomics PLC) ; Koelling, N. (Genomics PLC) ; Fowler, T. (Roslin Institute. University of Edinburgh) ; Pasko, D. (Roslin Institute. University of Edinburgh) ; Ball, C.A. (Ancestry) ; Hong, E.L. (Ancestry) ; Rand, K. (Ancestry) ; Girshick, A. (Ancestry) ; Guturu, H. (Ancestry) ; Baltzell, A.H. (Ancestry) ; Roberts, G. (Ancestry) ; Park, D. (Ancestry) ; Coignet, M. (Ancestry) ; McCurdy, S. (Ancestry) ; Knight, S. (Ancestry) ; Partha, R. (Ancestry) ; Rhead, B. (Ancestry) ; Zhang, M. (Ancestry) ; Berkowitz, Nathan (Ancestry) ; Gaddis, Michael (Ancestry) ; Noto, Keith (Ancestry) ; Ruiz, Luong (Ancestry) ; Pavlovic, Milos (Ancestry) ; Sloofman, Laura G. (Icahn School of Medicine at Mount Sinai) ; Charney, Alexander W. (Icahn School of Medicine at Mount Sinai) ; Beckmann, Noam D. (Icahn School of Medicine at Mount Sinai) ; Schadt, Eric E. (Icahn School of Medicine at Mount Sinai) ; Jordan, Daniel (Icahn School of Medicine at Mount Sinai) ; Thompson, Ryan C. (Icahn School of Medicine at Mount Sinai) ; Gettler, Kyle (Icahn School of Medicine at Mount Sinai) ; Abul-Husn, Noura S. (Icahn School of Medicine at Mount Sinai) ; Ascolillo, Steven (Icahn School of Medicine at Mount Sinai) ; Buxbaum, Joseph D (Icahn School of Medicine at Mount Sinai) ; Chaudhary, Kumardeep (Icahn School of Medicine at Mount Sinai) ; Cho, Judy H. (Icahn School of Medicine at Mount Sinai) ; Itan, Yuval (Icahn School of Medicine at Mount Sinai) ; Kenny, Eimear E. (Icahn School of Medicine at Mount Sinai) ; Belbin, Gillian Morven (Icahn School of Medicine at Mount Sinai) ; Sealfon, Stuart (Icahn School of Medicine at Mount Sinai) ; Sebra, Robert P. (Icahn School of Medicine at Mount Sinai) ; Salib, Irene (Icahn School of Medicine at Mount Sinai) ; Collins, Brett L. (Icahn School of Medicine at Mount Sinai) ; Levy, Tess (Icahn School of Medicine at Mount Sinai) ; Britvan, Bari (Icahn School of Medicine at Mount Sinai) ; Keller, Katherine (Icahn School of Medicine at Mount Sinai) ; Tang, Lara (Icahn School of Medicine at Mount Sinai) ; Peruggia, Michael (Icahn School of Medicine at Mount Sinai) ; Hiester, Liam L. (Icahn School of Medicine at Mount Sinai) ; Niblo, Kristi (Icahn School of Medicine at Mount Sinai) ; Aksentijevich, Alexandra (Icahn School of Medicine at Mount Sinai) ; Labkowsky, Alexander (Icahn School of Medicine at Mount Sinai) ; Karp, Avromie (Icahn School of Medicine at Mount Sinai) ; Zlatopolsky, Menachem (Icahn School of Medicine at Mount Sinai) ; Preuss, Michael (Icahn School of Medicine at Mount Sinai) ; Loos, Ruth J. F (Icahn School of Medicine at Mount Sinai) ; Nadkarni, Girish N. (Icahn School of Medicine at Mount Sinai) ; Do, Ron (Icahn School of Medicine at Mount Sinai) ; Hoggart, Clive (Icahn School of Medicine at Mount Sinai) ; Choi, Sam (Icahn School of Medicine at Mount Sinai) ; Underwood, Slayton J. (Icahn School of Medicine at Mount Sinai) ; O'Reilly, Paul (Icahn School of Medicine at Mount Sinai) ; Huckins, Laura M. (Icahn School of Medicine at Mount Sinai) ; Zyndorf, Marissa (Icahn School of Medicine at Mount Sinai) ; Daly, Mark J. (Broad Institute of MIT and Harvard) ; Neale, Benjamin M. (Broad Institute of MIT and Harvard) ; Ganna, Andrea (Broad Institute of MIT and Harvard)
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care or hospitalization after infection with SARS-CoV-2. [...]
2022 - 10.1038/s41586-022-04576-6
Nature, Vol. 607 Núm. 7917 (july 2022) , p. 97-103  
3.
7 p, 1.0 MB Genome-Wide Association Study of VKORC1 and CYP2C9 on acenocoumarol dose, stroke recurrence and intracranial haemorrhage in Spain / Cullell, Natalia (Institut d'Investigació Biomèdica Sant Pau) ; Carrera, Caty (Hospital Universitari Vall d'Hebron) ; Muiño, Elena (Institut d'Investigació Biomèdica Sant Pau) ; Torres-Aguila, Nuria P.. (Institut d'Investigació Biomèdica Sant Pau) ; Cárcel-Márquez, Jara (Institut d'Investigació Biomèdica Sant Pau) ; González-Sánchez, J. (Manchester Metropolitan University) ; Gallego-Fabrega, Cristina (Institut d'Investigació Biomèdica Sant Pau) ; Molina, J. (Hospital Universitari MútuaTerrassa/Fundacio Docència i Recerca MútuaTerrassa) ; Besora, S. (Hospital Universitari MútuaTerrassa/Fundacio Docència i Recerca MútuaTerrassa) ; Sotoca, J. (Hospital Universitari MútuaTerrassa/Fundacio Docència i Recerca MútuaTerrassa) ; Buongiorno, María Teresa (Hospital Universitari MútuaTerrassa/Fundacio Docència i Recerca MútuaTerrassa) ; Jiménez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ; Giralt Steinhauer, Eva (Institut Hospital del Mar d'Investigacions Mèdiques) ; de Torres-Chacón, R. (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ; Montaner, J. (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ; Mancha, Fernando (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ; Cabezas, Juan Antonio (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ; Martí-Fàbregas, Joan (Institut d'Investigació Biomèdica Sant Pau) ; Prats-Sánchez, Luis Antonio (Institut d'Investigació Biomèdica Sant Pau) ; Camps-Renom, Pol (Institut d'Investigació Biomèdica Sant Pau) ; Purroy, Francisco (Hospital Universitari Arnau de Vilanova) ; Cambray, S. (Universitat de Lleida) ; Freijo, M.d.M. (Hospital de Basurto (Bilbao, Biscaia)) ; Vives-Bauzá, C. (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ; Tur, S. (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ; Font, M.À. (Hospital Moisès Broggi) ; López-Cancio, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Hernández-Pérez, María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Obach, Víctor (Hospital Clínic i Provincial de Barcelona) ; Calleja, Ana (Hospital Clínico Universitario de Valladolid) ; Arenillas, Juan F (Hospital Clínico Universitario de Valladolid) ; Rodríguez-Yáñez, M. (Fundación Instituto de Investigación Sanitaria de Santiago [IDIS]) ; Castillo, J. (Fundación Instituto de Investigación Sanitaria de Santiago [IDIS]) ; Sobrino, T. (Fundación Instituto de Investigación Sanitaria de Santiago [IDIS]) ; Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ; Krupinski, J. (Manchester Metropolitan University) ; Universitat Autònoma de Barcelona
Acenocoumarol is an oral anticoagulant with significant interindividual dose variations. Variants in CYP2C9 and VKORC1 have been associated with acenocoumarol maintenance dose. We analysed whether any of the 49 polymorphisms in CYP2C9 and VKORC1 previously associated with acenocoumarol maintenance dose in a Genome-Wide Association study (GWAs) in Dutch population are associated with stroke recurrence, intracranial haemorrhage (ICH) and acenocoumarol maintenance dose in a Spanish population. [...]
2020 - 10.1038/s41598-020-59641-9
Scientific reports, Vol. 10 Núm. 1 (january 2020) , p. 2806  
4.
34 p, 16.2 MB Stroke genetics informs drug discovery and risk prediction across ancestries / Mishra, Aniket (University of Bordeaux, Inserm, UMR 1219. Bordeaux Population Health Research Center) ; Malik, Rainer (University Hospital, LMU Munich. Institute for Stroke and Dementia Research (ISD)) ; Hachiya, Tsuyoshi (Iwate Medical University. Iwate Tohoku Medical Megabank Organization) ; Jürgenson, Tuuli (University of Tartu. Institute of Mathematics and Statistics) ; Namba, Shinichi (Osaka University Graduate School of Medicine. Department of Statistical Genetics) ; Posner, Daniel C. (VA Boston Healthcare System. Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC)) ; Kamanu, Frederick K. (Harvard Medical School. Division of Cardiovascular Medicine, Brigham and Women's Hospital) ; Koido, Masaru (The University of Tokyo. Laboratory of Complex Trait Genomics, Graduate School of Frontier Sciences) ; Le Grand, Quentin (University of Bordeaux, Inserm, UMR 1219. Bordeaux Population Health Research Center) ; Shi, Mingyang (The University of Tokyo. Laboratory of Complex Trait Genomics, Graduate School of Frontier Sciences) ; He, Yunye (The University of Tokyo. Laboratory of Complex Trait Genomics, Graduate School of Frontier Sciences) ; Georgakis, Marios K. (Broad Institute of Harvard and the Massachusetts Institute of Technology. Program in Medical and Population Genetics) ; Caro, Ilana (University of Bordeaux, Inserm, UMR 1219. Bordeaux Population Health Research Center) ; Krebs, Kristi (University of Tartu. Estonian Genome Centre, Institute of Genomics) ; Liaw, Yi-Ching (Chung Shan Medical University. Department of Public Health and Institute of Public Health) ; Vaura, Felix C. (Finnish Institute for Health and Welfare. Department of Public Health and Welfare) ; Lin, Kuang (University of Oxford. Nuffield Department of Population Health) ; Winsvold, Bendik Slagsvold (Oslo University Hospital (Oslo, Noruega)) ; Srinivasasainagendra, Vinodh (University of Alabama at Birmingham. Department of Biostatistics, School of Public Health) ; Parodi, Livia (Broad Institute of Harvard and the Massachusetts Institute of Technology. Program in Medical and Population Genetics) ; Bae, Hee-Joon (Seoul National University Bundang Hospital, Seoul National University College of Medicine. Department of Neurology and Cerebrovascular Disease Center) ; Chauhan, Ganesh (Rajendra Institute of Medical Sciences) ; Chong, Michael R. (McMaster University. Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine) ; Tomppo, Liisa (Helsinki University Hospital) ; Akinyemi, Rufus (University of Ibadan. Neuroscience and Ageing Research Unit Institute for Advanced Medical Research and Training, College of Medicine) ; Roshchupkin, Gennady V. (Erasmus MC University Medical Center Rotterdam. Department of Radiology and Nuclear Medicine) ; Habib, Naomi (The Hebrew University of Jerusalem. The Edmond and Lily Safra Center for Brain Sciences) ; Jee, Yon Ho (Harvard T. H. Chan School of Public Health. Department of Epidemiology) ; Thomassen, Jesper Qvist (Copenhagen University Hospital-Rigshospitalet. Department of Clinical Biochemistry) ; Abedi, Vida (The Pennsylvania State University. Department of Public Health Sciences, College of Medicine) ; Cárcel-Márquez, Jara (Institut d'Investigació Biomèdica Sant Pau) ; Nygaard, Marianne (Odense University Hospital (Dinamarca)) ; Leonard, Hampton L. (Data Tecnica International) ; Yang, Chaojie (University of Virginia. Department of Biochemistry and Molecular Genetics) ; Yonova-Doing, Ekaterina (Novo Nordisk Research Centre Oxford. Department of Genetics) ; Knol, Maria J. (Erasmus MC University Medical Center Rotterdam. Department of Epidemiology) ; Lewis, Adam J. (Vanderbilt University Medical Center. Department of Biomedical Informatics) ; Judy, Renae L. (University of Pennsylvania. Department of Surgery) ; Ago, Tetsuro (Kyushu University. Department of Medicine and Clinical Science, Graduate School of Medical Sciences) ; Amouyel, Philippe (Institut Pasteur de Lille) ; Armstrong, Nicole D. (University of Alabama at Birmingham. Department of Epidemiology) ; Bakker, Mark K. (University Medical Center Utrecht, University Utrecht. UMC Utrecht Brain Center, Department of Neurology and Neurosurgery) ; Bartz, Traci M. (University of Washington. Department of Biostatistics) ; Bennett, David A. (Rush University Medical Center. Rush Alzheimer's Disease Center) ; Bis, Joshua C (University of Washington. Cardiovascular Health Research Unit, Department of Medicine) ; Bordes, Constance (University of Bordeaux, Inserm, UMR 1219. Bordeaux Population Health Research Center) ; Børte, Sigrid (Oslo University Hospital. Research and Communication Unit for Musculoskeletal Health (FORMI), Department of Research and Innovation, Division of Clinical Neuroscience) ; Cain, Anael (The Hebrew University of Jerusalem. The Edmond and Lily Safra Center for Brain Sciences) ; Ridker, Paul M. (Harvard Medical School) ; Cho, Kelly (VA Boston Healthcare System. Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC)) ; Chen, Zhengming (University of Oxford. MRC Population Health Research Unit) ; Cruchaga, Carlos (Washington University School of Medicine. NeuroGenomics and Informatics Center) ; Cole, John W. (University of Maryland School of Medicine. Department of Neurology) ; De Jager, Philip L (Columbia University Medical Center. Center for Translational and Computational Neuroimmunology, Department of Neurology) ; de Cid, Rafael (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Endres, Matthias (partner site Berlin. German Centre for Cardiovascular Research (DZHK)) ; Ferreira, Leslie E. (Post-Graduation Program on Health and Environment, Department of Medicine and Joinville Stroke Biobank, University of the Region of Joinville, Santa Catarina, Brazil) ; Geerlings, Mirjam I. (University Medical Center Utrecht, Utrecht University. Department of Epidemiology, Julius Center for Health Sciences and Primary Care) ; Gasca, Natalie C. (University of Washington. Department of Biostatistics) ; Gudnason, Vilmundur (University of Iceland. Faculty of Medicine) ; Hata, Jun (Kyushu University. Department of Epidemiology and Public Health, Graduate School of Medical Sciences) ; He, Jing (Vanderbilt University Medical Center. Department of Biomedical Informatics) ; Heath, Alicia K. (Imperial College London. Department of Epidemiology and Biostatistics, School of Public Health) ; Ho, Yuk-Lam (VA Boston Healthcare System. Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC)) ; Havulinna, Aki S (FIMM-HiLIFE. Institute for Molecular Medicine Finland) ; Hopewell, Jemma C. (University of Oxford. Clinical Trial Service and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health) ; Hyacinth, Hyacinth I. (University of Cincinnati College of Medicine. Department of Neurology and Rehabilitation Medicine) ; Inouye, Michael (University of Cambridge. British Heart Foundation Centre of Research Excellence) ; Jacob, Mina A. (Radboud University Medical Center. Department of Neurology, Donders Center for Medical Neuroscience) ; Jeon, Christina E. (Los Angeles County Department of Public Health) ; Jern, Christina (Sahlgrenska University Hospital (Suècia)) ; Kamouchi, Masahiro (Kyushu University. Department of Health Care Administration and Management, Graduate School of Medical Sciences) ; Keene, Keith L. (East Carolina University. Department of Biology, Brody School of Medicine Center for Health Disparities) ; Kitazono, Takanari (Kyushu University. Department of Medicine and Clinical Science, Graduate School of Medical Sciences) ; Kittner, Steven J. (VA Maryland Health Care System. Department of Neurology and Geriatric Research and Education Clinical Center) ; Konuma, Takahiro (Osaka University Graduate School of Medicine. Department of Statistical Genetics) ; Kumar, Amit (Rajendra Institute of Medical Sciences) ; Lacaze, Paul (Monash University. Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine) ; Launer, Lenore Joy (National Institute on Aging, NIH. Intramural Research Program) ; Lee, Keon-Joo (Korea University Guro Hospital. Department of Neurology) ; Lepik, Kaido (University Center for Primary Care and Public Health, Lausanne, Switzerland) ; Li, Jiang (Geisinger Health System. Department of Molecular and Functional Genomics, Weis Center for Research) ; Li, Liming (Peking University Health Science Center. Department of Epidemiology and Biostatistics, School of Public Health) ; Manichaikul, Ani (University of Virginia. Center for Public Health Genomics) ; Markus, Hugh S. (University of Cambridge. Stroke Research Group, Department of Clinical Neurosciences) ; Marston, Nicholas A. (Harvard Medical School. Division of Cardiovascular Medicine, Brigham and Women's Hospital) ; Meitinger, Thomas (German Research Center for Environmental Health. Institute of Human Genetics, Helmholtz Zentrum München) ; Mitchell, Braxton D. (Baltimore Veterans Administration Medical Center. Geriatrics Research and Education Clinical Center) ; Montellano, Felipe A. (University Hospital Würzburg. Department of Neurology) ; Morisaki, Takayuki (The University of Tokyo. Division of Molecular Pathology, Institute of Medical Sciences) ; Mosley, Thomas H. (University of Mississippi Medical Center. The MIND Center) ; Nalls, Mike A. (Data Tecnica International) ; Nordestgaard, Børge G. (University of Copenhagen. Department of Clinical Medicine) ; O'Donnell, Martin J. (NUI Galway. College of Medicine Nursing and Health Science) ; Okada, Yukinori (Osaka University. Center for Infectious Disease Education and Research (CiDER)) ; Onland-Moret, N. Charlotte (University Medical Center Utrecht, Utrecht University. Department of Epidemiology, Julius Center for Health Sciences and Primary Care) ; Ovbiagele, Bruce (University of California, San Francisco. Weill Institute for Neurosciences) ; Peters, Annette (German Centre for Cardiovascular Research (DZHK), partner site Munich) ; Psaty, Bruce M. (University of Washington. Department of Health Systems and Population Health) ; Rich, Stephen S. (University of Virginia. Center for Public Health Genomics) ; Rosand, Jonathan (Massachusetts General Hospital. McCance Center for Brain Health) ; Sabatine, Marc S. (Harvard Medical School. Division of Cardiovascular Medicine, Brigham and Women's Hospital) ; Sacco, Ralph L. (Evelyn F. McKnight Brain Institute) ; Saleheen, Danish (Columbia University. Division of Cardiology, Department of Medicine) ; Sandset, Else Charlotte (The Norwegian Air Ambulance Foundation. Research and Development) ; Salomaa, Veikko (Finnish Institute for Health and Welfare. Department of Public Health and Welfare) ; Sargurupremraj, Muralidharan (University of Texas Health Sciences Center. Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases) ; Sasaki, Makoto (Iwate Medical University. Iwate Tohoku Medical Megabank Organization) ; Satizabal, Claudia L. (Framingham Heart Study) ; Schmidt, Carsten O. (University Medicine Greifswald, Institute for Community Medicine, SHIP/KEF) ; Shimizu, Atsushi (Iwate Medical University. Iwate Tohoku Medical Megabank Organization) ; Smith, Nicholas L. (Seattle Epidemiologic Research and Information Center. Department of Veterans Affairs Office of Research and Development) ; Sloane, Kelly L. (University of Pennsylvania. Department of Neurology) ; Sutoh, Yoichi (Iwate Medical University. Iwate Tohoku Medical Megabank Organization) ; Sun, Yan V. (Emory University Rollins School of Public Health. Department of Epidemiology) ; Tanno, Kozo (Iwate Medical University. Iwate Tohoku Medical Megabank Organization) ; Tiedt, Steffen (University Hospital, LMU Munich. Institute for Stroke and Dementia Research (ISD)) ; Tatlisumak, Turgut (Sahlgrenska University Hospital (Suècia)) ; Torres-Aguila, Nuria P.. (Institut d'Investigació Biomèdica Sant Pau) ; Tiwari, Hemant K. (University of Alabama at Birmingham. Department of Biostatistics, School of Public Health) ; Trégouët, David-Alexandre (University of Bordeaux, Inserm, UMR 1219. Bordeaux Population Health Research Center) ; Trompet, Stella (Leiden University Medical Center. Department of Cardiology) ; Tuladhar, Anil Man (Radboud University Medical Center. Department of Neurology, Donders Center for Medical Neuroscience) ; Tybjærg-Hansen, Anne (University of Copenhagen. Department of Clinical Medicine) ; van Vugt, Marion (University Medical Center Utrecht, Utrecht University. Division Heart & Lungs, Department of Cardiology) ; Vibo, Riina (University of Tartu. Department of Neurology and Neurosurgery) ; Verma, Shefali S. (University of Pennsylvania. Department of Pathology and Laboratory Medicine) ; Wiggins, Kerri L. (University of Washington. Cardiovascular Health Research Unit, Department of Medicine) ; Wennberg, Patrik (Umeå University. Department of Public Health and Clinical Medicine) ; Woo, Daniel (University of Cincinnati College of Medicine. Department of Neurology and Rehabilitation Medicine) ; Wilson, Peter W. F. (Emory University School of Medicine. Department of Medicine, Division of Cardiovascular Disease) ; Xu, Huichun (University of Maryland School of Medicine. Department of Medicine) ; Yang, Qiong (Boston University School of Public Health. Department of Biostatistics) ; Yoon, Kyungheon (National Institute of Health. Division of Genome Science, Department of Precision Medicine) ; Millwood, Iona Y. (University of Oxford. MRC Population Health Research Unit) ; Gieger, Christian (German Research Center for Environmental Health. Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München) ; Ninomiya, Toshiharu (Kyushu University. Department of Epidemiology and Public Health, Graduate School of Medical Sciences) ; Grabe, Hans J. (German Center for Neurodegenerative Diseases (DZNE), site Rostock/Greifswald) ; Jukema, J. Wouter (LUMC. Einthoven Laboratory for Experimental Vascular Medicine) ; Rissanen, Ina L. (University Medical Center Utrecht, Utrecht University. Department of Epidemiology, Julius Center for Health Sciences and Primary Care) ; Strbian, Daniel (Helsinki University Hospital) ; Kim, Young Jin (National Institute of Health. Division of Genome Science, Department of Precision Medicine) ; Chen, Pei-Hsin (Chung Shan Medical University. Department of Public Health and Institute of Public Health) ; Mayerhofer, Ernst (Broad Institute of Harvard and the Massachusetts Institute of Technology. Program in Medical and Population Genetics) ; Howson, Joanna M. M. (Novo Nordisk Research Centre Oxford. Department of Genetics) ; Irvin, Marguerite R. (University of Alabama at Birmingham. Department of Epidemiology) ; Adams, Hieab (Universidad Adolfo Ibáñez. Latin American Brain Health (BrainLat)) ; Wassertheil-Smoller, Sylvia (Albert Einstein College of Medicine. Department of Epidemiology and Population Health) ; Christensen, Kaare (Odense University Hospital (Dinamarca)) ; Ikram, M. Arfan (Erasmus MC University Medical Center Rotterdam. Department of Epidemiology) ; Rundek, Tatjana (Evelyn F. McKnight Brain Institute) ; Worrall, Bradford B. (University of Virginia. Department of Public Health Science) ; Lathrop, G. Mark (McGill Genome Centre) ; Riaz, Moeen (Monash University. Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine) ; Simonsick, Eleanor M. (National Institute on Aging. Longitudinal Studies Section, Translational Gerontology Branch) ; Kõrv, Janika (University of Tartu. Department of Neurology and Neurosurgery) ; França, Paulo H. C. (Post-Graduation Program on Health and Environment, Department of Medicine and Joinville Stroke Biobank, University of the Region of Joinville, Santa Catarina, Brazil) ; Zand, Ramin (The Pennsylvania State University. Department of Neurology, College of Medicine) ; Prasad, Kameshwar (Rajendra Institute of Medical Sciences) ; Frikke-Schmidt, Ruth (University of Copenhagen. Department of Clinical Medicine) ; de Leeuw, Frank-Erik (Radboud University Medical Center. Department of Neurology, Donders Center for Medical Neuroscience) ; Liman, Thomas (Carl von Ossietzky University of Oldenburg. Klinik für Neurologie) ; Haeusler, Karl Georg (University Hospital Würzburg. Department of Neurology) ; Ruigrok, Ynte M. (University Medical Center Utrecht, University Utrecht. UMC Utrecht Brain Center, Department of Neurology and Neurosurgery) ; Heuschmann, Peter Ulrich (University Hospital Würzburg. Clinical Trial Center) ; Longstreth, W. T. (University of Washington. Department of Neurology) ; Jung, Keum Ji (Yonsei University. Institute for Health Promotion, Graduate School of Public Health) ; Bastarache, Lisa (Vanderbilt University Medical Center. Department of Biomedical Informatics) ; Paré, Guillaume (David Braley Cardiac, Vascular and Stroke Research Institute. Population Health Research Institute) ; Damrauer, Scott M. (Corporal Michael Crescenz VA Medical Center) ; Chasman, Daniel I. (Harvard Medical School) ; Rotter, Jerome I. (The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center. The Institute for Translational Genomics and Population Sciences, Department of Pediatrics) ; Anderson, Christopher D. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ; Zwart, John-Anker (University of Oslo. Institute of Clinical Medicine, Faculty of Medicine) ; Niiranen, Teemu J. (Turku University Hospital. Division of Medicine) ; Fornage, Myriam (University of Texas Health Science Center at Houston. Human Genetics Center, School of Public Health) ; Liaw, Yung-Po (Chung Shan Medical University Hospital. Department of Medical Imaging) ; Seshadri, Sudha (Boston University School of Medicine. Department of Neurology) ; Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ; Walters, Robin G. (University of Oxford. MRC Population Health Research Unit) ; Ruff, Christian T. (Harvard Medical School. Division of Cardiovascular Medicine, Brigham and Women's Hospital) ; Owolabi, Mayowa O. (University of Ibadan. Department of Medicine) ; Huffman, Jennifer E. (VA Boston Healthcare System. Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC)) ; Milani, Lili (University of Tartu. Estonian Genome Centre, Institute of Genomics) ; Kamatani, Yoichiro (The University of Tokyo. Laboratory of Complex Trait Genomics, Graduate School of Frontier Sciences) ; Dichgans, Martin (German Center for Neurodegenerative Diseases (DZNE)) ; Debette, Stéphanie (CHU de Bordeaux. Department of Neurology, Institute for Neurodegenerative Diseases) ; Universitat Autònoma de Barcelona
Previous genome-wide association studies (GWASs) of stroke - the second leading cause of death worldwide - were conducted predominantly in populations of European ancestry ,. Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. [...]
2022 - 10.1038/s41586-022-05165-3
Nature, september 2022, p. 1-15  
5.
32 p, 9.6 MB Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease / Duperron, Marie-Gabrielle (Bordeaux University Hospital(França)) ; Knol, Maria J. (Erasmus MC University Medical Center) ; Le Grand, Quentin (Bordeaux Population Health Research Center) ; Evans, Tavia E. (Erasmus MC University Medical Center) ; Mishra, Aniket (University of Bordeaux) ; Tsuchida, Ami (University of Bordeaux) ; Roshchupkin, Gennady V (Erasmus MC University Medical Center) ; Konuma, Takahiro (Osaka University Graduate School of Medicine) ; Trégouët, David-Alexandre (University of Bordeaux) ; Romero, Jose Rafael (The Framingham Heart Study) ; Frenzel, Stefan (University Medicine Greifswald) ; Luciano, Michelle (University of Edinburgh) ; Hofer, Edith (Medical University of Graz) ; Bourgey, Mathieu (McGill University) ; Dueker, Nicole D. (University of Miami) ; Delgado Martínez, María Pilar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Hilal, Saima (National University of Singapore and National University Health System) ; Tankard, Rick M. (Curtin University) ; Dubost, Florian (Erasmus MC University Medical Center) ; Shin, Jean (University of Toronto) ; Saba, Yasaman (Medical University of Graz) ; Armstrong, Nicola (Curtin University) ; Bordes, Constance (Bordeaux Population Health Research Center) ; Bastin, Mark E. (University of Edinburgh) ; Beiser, Alexa (Boston University School of Public Health) ; Brodaty, Henry (Dementia Collaborative Research Centre Assessment and Better Care) ; Bülow, Robin (University Medicine Greifswald) ; Carrera, Caty (Institut d'Investigació Biomèdica Sant Pau) ; Chen, Christopher (National University of Singapore) ; Cheng, Ching-Yu (Duke-NUS Medical School) ; Deary, Ian J. (University of Edinburgh) ; Gampawar, Piyush G. (Medical University of Graz) ; Himali, Jayandra J. (UT Health San Antonio) ; Jiang, Jiyang (University of New South Wales) ; Kawaguchi, Takahisa (Kyoto University Graduate School of Medicine) ; Li, Shuo (Boston University School of Public Health) ; Macalli, Melissa (University of Bordeaux) ; Marquis, Pascale (McGill University) ; Morris, Zoe (Royal Infirmary of Edinburgh) ; Muñoz Maniega, Susana (UK Dementia Research Institute Centre at the University of Edinburgh) ; Miyamoto, Susumu (Kyoto University Hospital) ; Okawa, Masakazu (Kyoto University Graduate School of Medicine) ; Paradise, Matthew (University of New South Wales) ; Parva, Pedram (Harvard Medical School) ; Rundek, Tatjana (University of Miami) ; Sargurupremraj, Muralidharan (University of Bordeaux) ; Schilling, Sabrina (University of Bordeaux) ; Setoh, Kazuya (Shizuoka Graduate University of Public Health) ; Soukarieh, Omar (University of Bordeaux) ; Tabara, Yasuharu (Shizuoka Graduate University of Public Health) ; Teumer, Alexander (University Medicine Greifswald) ; Thalamuthu, Anbupalam (University of New South Wales) ; Trollor, Julian (UNSW) ; Valdés Hernández, Maria C. (University of Edinburgh) ; Vernooij, Meike W. (Erasmus MC University Medical Center) ; Völker, Uwe (University Medicine Greifswald) ; Wittfeld, Katharina (German Center for Neurodegenerative Diseases) ; Wong, Tien Yin (Tsinghua University) ; Wright, Margaret J. (University of Queensland) ; Zhang, Junyi (Peking Union Medical College Hospital) ; Zhao, Wanting (Duke-NUS Medical School) ; Zhu, Yi-Cheng (Peking Union Medical College Hospital) ; Schmidt, Helena (Medical University of Graz) ; Sachdev, Perminder S. (the Prince of Wales Hospital) ; Wen, Wei (University of New South Wales) ; Yoshida, Kazumichi (Kyoto University Graduate School of Medicine) ; Joutel, Anne (Université Paris Cité) ; Satizabal, Claudia L. (UT Health San Antonio) ; Sacco, Ralph L. (University of Miami) ; Bourque, Guillaume (McGill University) ; Lathrop, Mark (Victor Phillip Dahdaleh Institute of Genomic Medicine at McGill University) ; Paus, Tomas (University of Toronto) ; Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ; Yang, Qiong (Boston University School of Public Health) ; Mazoyer, Bernard (Bordeaux University Hospital (França)) ; Boutinaud, Philippe (Fealinx) ; Okada, Yukinori (University of Tokyo) ; Grabe, Hans J. (German Center for Neurodegenerative Diseases) ; Mather, Karen A (Neuroscience Research Australia) ; Schmidt, Reinhold (Medical University of Graz) ; Joliot, Marc (University of Bordeaux) ; Ikram, M. Arfan (Erasmus MC University Medical Center) ; Matsuda, Fumihiko (Kyoto University Graduate School of Medicine) ; Tzourio, Christophe (Bordeaux University Hospital(França)) ; Wardlaw, Joanna (University of Edinburgh) ; Seshadri, Sudha (UT Health San Antonio) ; Adams, Hieab (Universidad Adolfo Ibáñez) ; Debette, Stéphanie (Bordeaux University Hospital(França)) ; Universitat Autònoma de Barcelona
Perivascular space (PVS) burden is an emerging, poorly understood, magnetic resonance imaging marker of cerebral small vessel disease, a leading cause of stroke and dementia. Genome-wide association studies in up to 40,095 participants (18 population-based cohorts, 66. [...]
2023 - 10.1038/s41591-023-02268-w
Nature Medicine, Vol. 29 (april 2023) , p. 950-962  
6.
17 p, 1.3 MB Altered methylation pattern in EXOC4 is associated with stroke outcome : an epigenome-wide association study / Cullell, Natalia (Institut d'Investigació Biomèdica Sant Pau) ; Soriano Tárraga, Carolina (NeuroGenomics and Informatics. Washington University School of Medicine) ; Gallego-Fabrega, Cristina (Institut d'Investigació Biomèdica Sant Pau) ; Cárcel-Márquez, Jara (Institut d'Investigació Biomèdica Sant Pau) ; Muiño, Elena (Institut d'Investigació Biomèdica Sant Pau) ; Llucià-Carol, Laia (Institut d'Investigació Biomèdica Sant Pau) ; Lledós, Miquel (Institut d'Investigació Biomèdica Sant Pau) ; Esteller, M (Institució Catalana de Recerca i Estudis Avançats) ; Castro de Moura, Manuel (Programa de Epigenética y Biología del Cáncer (PEBC)) ; Montaner, Joan (Instituto de Biomedicina de Sevilla) ; Rosell Novel, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Delgado Martínez, María Pilar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Martí-Fàbregas, Joan (Institut d'Investigació Biomèdica Sant Pau) ; Krupinski, Jerzy (Centre for Bioscience. School of HealthCare Science. Manchester Metropolitan University) ; Roquer, Jaume (Institut Hospital del Mar d'Investigacions Mèdiques) ; Jiménez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ; Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ; Universitat Autònoma de Barcelona
Background and purpose: The neurological course after stroke is highly variable and is determined by demographic, clinical and genetic factors. However, other heritable factors such as epigenetic DNA methylation could play a role in neurological changes after stroke. [...]
2022 - 10.1186/s13148-022-01340-5
Clinical Epigenetics, Vol. 14 Núm. 1 (december 2022) , p. 124  
7.
12 p, 1.1 MB A Polygenic Risk Score Based on a Cardioembolic Stroke Multitrait Analysis Improves a Clinical Prediction Model for This Stroke Subtype / Cárcel-Márquez, Jara (Institut d'Investigació Biomèdica Sant Pau) ; Muiño, Elena (Institut d'Investigació Biomèdica Sant Pau) ; Gallego-Fabrega, Cristina (Institut d'Investigació Biomèdica Sant Pau) ; Cullell, Natalia (Institut d'Investigació Biomèdica Sant Pau) ; Lledós, Miquel (Institut d'Investigació Biomèdica Sant Pau) ; Llucià-Carol, Laia (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Sobrino, Tomás (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ; Campos, Francisco (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ; Castillo, José (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ; Freijo, Marimar (Biocruces-Bizkaia Health Research Institute. Department of Neurology) ; Arenillas, Juan F (Hospital Universitario de Valladolid) ; Obach, Víctor (Hospital Clínic i Provincial de Barcelona) ; Álvarez Sabín, José (Hospital Universitari Vall d'Hebron) ; Molina, Carlos A. (Hospital Universitari Vall d'Hebron) ; Ribó, Marc (Hospital Universitari Vall d'Hebron) ; Jiménez-Conde, Jordi (Hospital del Mar (Barcelona, Catalunya)) ; Roquer, Jaume (Hospital del Mar (Barcelona, Catalunya)) ; Muñoz-Narbona, Lucia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; López-Cancio, Elena (Hospital Central de Asturias (HUCA)) ; Millán, Mònica (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Diaz-Navarro, Rosa (Institut d'Investigació Sanitària Illes Balears) ; Vives-Bauza, Cristòfol (Institut d'Investigació Sanitària Illes Balears) ; Serrano-Heras, Gemma (Complejo Hospitalario Universitario de Albacete) ; Segura, Tomás (Complejo Hospitalario Universitario de Albacete) ; Ibañez, Laura (Washington University School of Medicine. Department of Psychiatry) ; Heitsch, Laura (Washington University School of Medicine. Department of Neurology) ; Delgado, Pilar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Dhar, Rajat (Washington University School of Medicine. Department of Neurology.) ; Krupinski, Jerzy (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ; Delgado Mederos, Raquel (Institut d'Investigació Biomèdica Sant Pau) ; Prats-Sánchez, Luis Antonio (Institut d'Investigació Biomèdica Sant Pau) ; Camps-Renom, Pol (Institut d'Investigació Biomèdica Sant Pau) ; Blay, Natalia (Institut Germans Trias i Pujol) ; Sumoy, Lauro (Institut Germans Trias i Pujol) ; de Cid, Rafael (Institut Germans Trias i Pujol) ; Montaner, Joan (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ; Cruchaga, Carlos (Washington University in St. Louis. Neurogenomics and Informatics Center.) ; Lee, Jim-Moo (Washington University School of Medicine. Department of Neurology.) ; Martí-Fàbregas, Joan (Institut d'Investigació Biomèdica Sant Pau) ; Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ; Universitat Autònoma de Barcelona
Background: Occult atrial fibrillation (AF) is one of the major causes of embolic stroke of undetermined source (ESUS). Knowing the underlying etiology of an ESUS will reduce stroke recurrence and/or unnecessary use of anticoagulants. [...]
2022 - 10.3389/fcvm.2022.940696
Frontiers in Cardiovascular Medicine, Vol. 9 (august 2022) , p. 940696  
8.
17 p, 2.6 MB DNA methylation analyses identify an intronic ZDHHC6 locus associated with time to recurrent stroke in the Vitamin Intervention for Stroke Prevention (VISP) clinical trial / Davis Armstrong, N.M. (East Carolina University. Department of Biology) ; Chen, Wei-Min (University of Virginia. Department of Public Health Sciences) ; Hsu, F.C. (Wake Forest School of Medicine) ; Brewer, M.S. (East Carolina University. Department of Biology) ; Cullell, Natalia (Fundació per la Recerca Biomèdica i Social Mútua de Terrassa) ; Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ; Williams, S.R. (University of Virginia. Department of Neurology) ; Sale, M.M. (University of Virginia. Department of Public Health Sciences) ; Worrall, B.B. (University of Virginia. Department of Neurology) ; Keene, K.L. (East Carolina University. Brody School of Medicine)
Aberrant DNA methylation profiles have been implicated in numerous cardiovascular diseases; however, few studies have investigated how these epigenetic modifications contribute to stroke recurrence. The aim of this study was to identify methylation loci associated with the time to recurrent cerebro- and cardiovascular events in individuals of European and African descent. [...]
2021 - 10.1371/journal.pone.0254562
PloS one, Vol. 16 Núm. 7 July (july 2021) , p. e0254562  
9.
10 p, 1.8 MB Epigenome-wide association study of COVID-19 severity with respiratory failure / Castro de Moura, Manuel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Davalos, Veronica (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Planas-Serra, Laura (Institut d'Investigació Biomèdica de Bellvitge) ; Álvarez-Errico, Damiana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Arribas, Carles (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Ruiz, Montserrat (Institut d'Investigació Biomèdica de Bellvitge) ; Aguilera-Albesa, Sergio (Complejo Hospitalario de Navarra) ; Troya, Jesús (Hospital Universitario Infanta Leonor) ; Valencia Ramos, Juan (Hospital Universitario de Burgos) ; Vélez Santamaria, Valentina (Hospital Universitari de Bellvitge) ; Rodríguez-Palmero, Agustí (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Villar Garcia, Judit (Institut Hospital del Mar d'Investigacions Mèdiques) ; Horcajada, Juan Pablo (Institut Hospital del Mar d'Investigacions Mèdiques) ; Albu, Sergiu (Institut Guttmann Foundation. Badalona) ; Casasnovas, Carlos (Hospital Universitari de Bellvitge) ; Rull, Anna (Hospital Universitari Joan XXIII de Tarragona) ; Reverté Calvet, Laia (Hospital Universitari Joan XXIII de Tarragona) ; Dietl, Beatriz (Servei de malalties infeccioses Hospital Universitari MutuaTerrassa. Universitat de Barcelona) ; Dalmau, David (Universitat de Barcelona. Hospital Mútua de Terrassa) ; Arranz, María Jesús (Fundació Docència i Recerca Mútua Terrassa) ; Llucià-Carol, Laia (Stroke Pharmacogenomics and Genetics Group. Sant Pau Institute of Research. Sant Pau Hospital) ; Planas, Anna Maria (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Pérez-Tur, Jordi (Institut de Biomedicina de València-CSIC. CIBERNED. Unitat Mixta de Neurologia i Genètica) ; Fernandez-Cadenas, Israel (Stroke Pharmacogenomics and Genetics Group. Sant Pau Institute of Research. Sant Pau Hospital) ; Villares, Paula (Hospital Universitario HM Sanchinarro (Madrid)) ; Tenorio, Jair (Center for Biomedical Research on Rare Diseases (CIBERER). ISCIII) ; Colobrán Oriol, Roger (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Martín-Nalda, Andrea (Hospital Universitari Vall d'Hebron) ; Soler-Palacín, Pere (Hospital Universitari Vall d'Hebron) ; Vidal, Francesc (Hospital Universitari Joan XXIII de Tarragona) ; Pujol, Aurora 1968- (Institució Catalana de Recerca i Estudis Avançats) ; Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Background: Patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for the coronavirus disease 2019 (COVID-19), exhibit a wide spectrum of disease behaviour. [...]
2021 - 10.1016/j.ebiom.2021.103339
EBioMedicine, Vol. 66 (april 2021) , p. 103339  
10.
19 p, 7.4 MB Rp11-362k2.2:Rp11-767i20.1 genetic variation is associated with post-reperfusion therapy parenchymal hematoma. a gwas meta-analysis / Muiño, Elena (Institut d'Investigació Biomèdica Sant Pau) ; Cárcel-Márquez, Jara (Institut d'Investigació Biomèdica Sant Pau) ; Carrera, C. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Llucià-Carol, Laia (Institut d'Investigació Biomèdica Sant Pau) ; Gallego-Fabrega, Cristina (Institut d'Investigació Biomèdica Sant Pau) ; Cullell, Natalia (Fundació MútuaTerrassa per la Docència i la Recerca) ; Lledós, Miquel (Institut d'Investigació Biomèdica Sant Pau) ; Castillo, J. (Instituto de Investigación Sanitaria de Santiago (IDIS)) ; Sobrino, T. (Instituto de Investigación Sanitaria de Santiago (IDIS)) ; Campos, Francisco (Instituto de Investigación Sanitaria de Santiago (IDIS)) ; Rodríguez-Castro, E. (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ; Millán, M. (Institut Germans Trias i Pujol) ; Muñoz-Narbona, L. (Institut Germans Trias i Pujol) ; Bustamante, Alejandro (Institut Germans Trias i Pujol) ; López-Cancio, E. (Hospital Universitario Central de Asturias) ; Ribó, M. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Álvarez Sabín, José (Hospital Universitari Vall d'Hebron) ; Jiménez-Conde, J. (Institut Hospital del Mar d'Investigacions Mèdiques) ; Roquer, J. (Institut Hospital del Mar d'Investigacions Mèdiques) ; Giralt Steinhauer, Eva (Institut Hospital del Mar d'Investigacions Mèdiques) ; Soriano-Tárraga, C. (Institut Hospital del Mar d'Investigacions Mèdiques) ; Vives-Bauza, C. (Instituto de Investigación Sanitaria de Palma) ; Díaz Navarro, R. (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ; Tur, S. (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ; Obach, V. (Hospital Clínic i Provincial de Barcelona) ; Arenillas, Juan F.. (Hospital Clínico Universitario de Valladolid) ; Segura, T. (Complejo Hospitalario Universitario de Albacete) ; Serrano-Heras, G. (Complejo Hospitalario Universitario de Albacete) ; Martí-Fàbregas, Joan (Institut d'Investigació Biomèdica Sant Pau) ; Delgado Mederos, Raquel (Institut d'Investigació Biomèdica Sant Pau) ; Camps-Renom, Pol (Institut d'Investigació Biomèdica Sant Pau) ; Prats-Sánchez, Luis Antonio (Institut d'Investigació Biomèdica Sant Pau) ; Guisado-Alonso, Daniel (Institut d'Investigació Biomèdica Sant Pau) ; Guasch-Jiménez, Marina (Institut d'Investigació Biomèdica Sant Pau) ; Marin, Rebeca (Institut d'Investigació Biomèdica Sant Pau) ; Martínez-Domeño, Alejandro (Institut d'Investigació Biomèdica Sant Pau) ; Freijo-Guerrero, M.D.M. (Instituto de Investigación Sanitaria Biocruces Bizkaia) ; Moniche, F. (Instituto de Biomedicina de Sevilla) ; Cabezas, Juan Antonio (Instituto de Biomedicina de Sevilla) ; Castellanos, M. (Complejo Hospitalario Universitario de A Coruña) ; Krupinsky, J. (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ; Strbian, D. (Helsinki University Hospital (Finlàndia)) ; Tatlisumak, T. (Sahlgrenska University Hospital (Suècia)) ; Thijs, V. (Austin Health. Department of Neurology) ; Lemmens, R. (University Hospitals Leuven (Bèlgica)) ; Slowik, A. (Jagiellonian University Medical College) ; Pera, J. (Jagiellonian University Medical College) ; Heitsch, Laura (Washington University School of Medicine) ; Ibañez, Laura (Washington University School of Medicine) ; Cruchaga, Carlos (Washington University School of Medicine) ; Dhar, R. (Washington University School of Medicine) ; Lee, J.M. (Washington University School of Medicine) ; Montaner, J. (Instituto de Biomedicina de Sevilla) ; Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ; Universitat Autònoma de Barcelona
Stroke is one of the most common causes of death and disability. Reperfusion therapies are the only treatment available during the acute phase of stroke. Due to recent clinical trials, these therapies may increase their frequency of use by extending the time-window administration, which may lead to an increase in complications such as hemorrhagic transformation, with parenchymal hematoma (PH) being the more severe subtype, associated with higher mortality and disability rates. [...]
2021 - 10.3390/jcm10143137
Journal of clinical medicine, Vol. 10 Núm. 14 (february 2021) , p. 3137  

Articles : 39 records found   1 - 10nextend  jump to record:
Research literature 5 records found  
1.
7.8 MB Study of genetic risk factors associated with ischemic stroke / Cárcel-Márquez, Jara ; Fernández Cadenas, Israel, dir. ; Martí i Fàbregas, Joan, dir.
Aquesta tesi amplia el nostre coneixement sobre aspectes claus de la genòmica de l'ictus isquèmic. L'objectiu principal de la present tesi doctoral és aprofundir en els factors de risc genètics associats a l'ictus isquèmic i fer-los servir per trobar noves associacions. [...]
Esta tesis amplía nuestro conocimiento de los aspectos clave de los enfoques genómicos que pueden aplicarse en el estudio del ictus isquémico. El objetivo principal de la presente tesis doctoral es profundizar en los factores de riesgo genéticos asociados al ictus isquémico y usarlos para encontrar nuevas asociaciones. [...]
This thesis widens our knowledge of key aspects of genomics approaches that can be implemented in the study of ischemic stroke. The main objective of the present thesis dissertation is to dig into the genetic risk factors associated with ischemic stroke and use them to find novel associations. [...]

2023  
2.
184 p, 4.5 MB Análisis de la etiopatogenia del cadasil mediante estudios transcriptómicos y estimación del pronóstico tras el ictus isquémico en el cadasil / Muiño, Elena ; Fernandez-Cadenas, Israel, dir. ; Roquer González, Jaume, dir. ; Montaner Villalonga, Joan, dir. ; Universitat Autònoma de Barcelona. Departament de Medicina
El CADASIL és una arteriopatia sistèmica causada per mutacions en NOTCH3, que afecten el nombre de cisteïnes del domini extracel·lular del receptor, alterant els ponts disulfur i propiciant un mal plegament d'aquest, i la seva agregació juntament amb la d'altres proteïnes; mecanisme que actualment es considera responsable de la malaltia. [...]
El CADASIL es una arteriopatía sistémica causada por mutaciones en NOTCH3, que afectan al número de cisteínas del dominio extracelular del receptor, alterando los puentes disulfuro y propiciando un mal plegamiento de este, y su agregación junto con la de otras proteínas; mecanismo que actualmente se considera responsable de la enfermedad. [...]
CADASIL is a systemic artery disease caused by mutations in NOTCH3, which affect the number of cysteines in the extracellular domain of the receptor, altering the disulfide bridges and causing a missfolding of the receptor, and its aggregation along with other proteins; a mechanism currently considered responsible for the disease. [...]

2020  
3.
366 p, 5.6 MB Genètica aplicada a la clínica neurovascular / Río Espínola, Alberto del ; Fernandez-Cadenas, Israel, dir. ; Montaner, Joan, dir. ; Álvarez Sabín, José, dir. ; Universitat Autònoma de Barcelona. Departament de Medicina
En aquesta tesi doctoral es descriuen els resultats de l'estudi farmacogenètic Geno-tPA, en el qual es va analitzar el paper de centenars de polimorfismes (SNPs) en la resposta al tractament trombolític de l'ictus isquèmic: recanalització arterial una hora després de la infusió, reoclusión arterial després d'haver recanalitzar, aparició de transformació hemorràgica iatrogènica i mortalitat intrahospitalària. [...]
This thesis describes the results of the Geno-tPA pharmacogenetic study, which analyzed the role of hundreds of polymorphisms (SNPs) in the response to thrombolytic treatmentof ischemic stroke: recanalization one hour after t-PA infusion, arterial reocclusion of the recanalized artery, presence of iatrogenic hemorrhagic transformation and in-hospital mortality. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2011  
4.
242 p, 3.2 MB Utilidad de los biomarcadores plasmáticos en el diagnóstico, tratamiento y pronóstico de la enfermedad cerebrovascular aguda / Mendioroz Iriarte, M. Teresa ; Montaner, Joan, dir. ; Álvarez Sabín, José, dir. ; Fernandez-Cadenas, Israel, dir. ; Universitat Autònoma de Barcelona. Departament de Medicina
[Barcelona] : Universitat Autònoma de Barcelona, 2010  
5.
207 p, 5.4 MB Identificación y uso de biomarcadores pronósticos en el ictus isquémico / García-Berrocoso, Teresa ; Montaner, Joan, dir. ; Fernandez-Cadenas, Israel, dir. ; Delgado Martínez, María Pilar, dir. ; García-Dorado, David, tut. ; Universitat Autònoma de Barcelona. Departament d'Antropologia Social i Cultural
El ictus es una enfermedad con una elevada morbimortalidad, suponiendo la segunda causa de muerte a nivel mundial y una de las principales causas de discapacidad en el adulto. Aun así, la heterogeneidad entre los pacientes con ictus dificulta anticipar el pronóstico de la enfermedad. [...]
Stroke is a severe disease, being the second cause of death worldwide and one of the main causes of disability. Heterogeneity among stroke patients makes difficult to anticipate the prognosis of the disease. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2014  

Course materials 1 records found  
1.
7 p, 114.9 KB Bases biològiques de la patologia [101883] / Casademont i Pou, Jordi ; Sierra Gil, Jorge ; Martinez-Pasarell, Olga ; Surralles Calonge, Jordi ; Corcoy i Pla, Rosa ; Maroto Rey, Jose Pablo ; Gràcia García, Silvia ; Blanco Vaca, Francisco ; Hernandez De Sosa, Nerea ; Guirado Perich, Luis ; Torra Balcells, Maria Roser ; Ars Criach, Elisabet ; Benito Hernández, M. Natividad de ; Barnadas i Molins, Agustí ; Lopez Contreras Gonzalez, Joaquin ; Filella Agullo, David ; Maestro, Alba ; Ramon Y Cajal Asensio, Teresa ; Alvarado-Tapias, Edilmar ; Osuna Gómez, Rubén ; Amorós-Figueras, Gerard ; Bejanin, Alexandre ; Matas Pericas, Laia ; Díaz Torne, César ; Fernandez Cadenas, Israel ; Castellvi Barranco, Ivan ; Francia Santamaria, Esther ; Laiz Alonso, Ana Maria ; Guerra Ramos, Jose Maria ; Torres Bonafonte, Olga Herminia ; Barceló Trias, Montserrat ; Gallardo, Eduard ; Universitat Autònoma de Barcelona. Facultat de Biociències
L'objectiu fonamental de l'assignatura és entrar en contacte amb el tipus de recerca que es fa en un entorn hospitalari. És una recerca que intenta respondre a preguntes orientades a la comprensió dels aspectes generals i bàsics de les malalties. [...]
The fundamental objective of the subject is to get in touch with the type of research that is carried out in a hospital environment. It is research that tries to answer questions aimed at understanding the general and basic aspects of diseases. [...]
El objetivo fundamental de la asignatura es entrar en contacto con el tipo de investigación que se realiza en un entorno hospitalario. Es una investigación que intenta responder a preguntas orientadas a la comprensión de los aspectos generales y básicos de las enfermedades. [...]

2023-24
Grau en Ciències Biomèdiques [832]
3 documents

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