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Artículos, Encontrados 16 registros
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Artículos Encontrados 16 registros  1 - 10siguiente  ir al registro:
1.
11 p, 1.9 MB Genetic basis of lacunar stroke : a pooled analysis of individual patient data and genome-wide association studies / Traylor, Matthew (Clinical Pharmacology and The Barts Heart Centre and NIHR Barts Biomedical Research Centre, Barts Health NHS Trust, William Harvey Research Institute, Queen Mary University of London, London, UK) ; Persyn, Elodie (King's College London) ; Tomppo, Liisa (Department of Neurology, Helsinki University Hospital, Helsinki, Finland) ; Klasson, Sofia (Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden) ; Abedi, Vida (Department of Molecular and Functional Genomics, Weis Center for Research, Geisinger Health System, Danville, PA, USA) ; Bakker, Mark K (Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands) ; Torres, Nuria (Institut d'Investigació Biomèdica Sant Pau) ; Li, Linxin (Centre for the Prevention of Stroke and Dementia, Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford, UK) ; Bell, Steven (Clinical Neurosciences, University of Cambridge, Cambridge, UK) ; Rutten-Jacobs, Loes (Product Development Personalized Health Care, F Hoffmann-La Roche, Basel, Switzerland) ; Tozer, Daniel J (Clinical Neurosciences, University of Cambridge, Cambridge, UK) ; Griessenauer, Christoph J (Institute of Neurointervention, Paracelsus Medical University, Salzburg, Austria) ; Zhang, Yanfei (Genomic Medicine Institute, Geisinger Health System, Danville, PA, USA) ; Pedersen, Annie (Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden) ; Sharma, Pankaj (Institute of Cardiovascular Research, Royal Holloway University of London, London, UK) ; Jimenez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ; Rundek, Tatjana (Evelyn F McKnight Brain Institute, Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA) ; Grewal, Raji P (Neuroscience Institute, Saint Francis Medical Center, School of Health and Medical Sciences, Seton Hall University, South Orange, NJ, USA) ; Lindgren, Arne (Department of Clinical Sciences Lund, Neurology, Lund University, Lund, Sweden) ; Meschia, James F (Department of Neurology, Mayo Clinic, Jacksonville, FL, USA) ; Salomaa, Veikko (Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland) ; Havulinna, Aki (Institute for Molecular Medicine Finland (FIMM HiLIFE), Helsinki, Finland) ; Kourkoulis, Christina (Program in Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA) ; Crawford, Katherine (Program in Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA) ; Marini, Sandro (Program in Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA) ; Mitchell, Braxton D (Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA) ; Kittner, Steven J (Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA) ; Rosand, Jonathan (Program in Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA) ; Dichgans, Martin (Munich Cluster for Systems Neurology (SyNergy), Munich, Germany) ; Jern, Christina (Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden) ; Strbian, Daniel (Clinical Neurosciences, University of Helsinki, Helsinki, Finland) ; Fernandez-Cadenas, Israel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Zand, Ramin (Neuroscience Institute, Geisinger Health System, Danville, PA, USA) ; Ruigrok, Ynte (Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands) ; Rost, Natalia (Massachusetts General Hospital) ; Lemmens, Robin (VIB Center for Brain & Disease Research, Department of Neurology, University Hospitals Leuven, Leuven, Belgium) ; Rothwell, Peter M (Centre for the Prevention of Stroke and Dementia, Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford, UK) ; Anderson, Christopher D (Program in Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA) ; Wardlaw, Joanna (Centre for Clinical Brain Sciences, UK Dementia Research Institute and Row Fogo Centre for Research into the Ageing Brain, University of Edinburgh, Edinburgh, UK) ; Lewis, Cathryn M (Social, Genetic, and Developmental Psychiatry Centre, King's College London, London, UK) ; Markus, Hugh S (Clinical Neurosciences, University of Cambridge, Cambridge, UK) ; Universitat Autònoma de Barcelona
The genetic basis of lacunar stroke is poorly understood, with a single locus on 16q24 identified to date. We sought to identify novel associations and provide mechanistic insights into the disease. [...]
2021 - 10.1016/S1474-4422(21)00031-4
The Lancet neurology, Vol. 20 (may 2021) , p. 351-361  
2.
21 p, 2.1 MB Pharmacogenetic studies with oral anticoagulants. Genome-wide association studies in vitamin K antagonist and direct oral anticoagulants / Cullell, Natalia (Stroke Pharmacogenomics and Genetics, Fundació Docència i Recerca Mútua Terrassa, Hospital Universitari Mútua de Terrassa, Terrassa, Barcelona, Spain) ; Carrera, Caty (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Muiño, Elena (Stroke Pharmacogenomics and Genetics, Fundació Docència i Recerca Mútua Terrassa, Hospital Universitari Mútua de Terrassa, Terrassa, Barcelona, Spain) ; Torres, Nuria (Stroke Pharmacogenomics and Genetics, Fundació Docència i Recerca Mútua Terrassa, Hospital Universitari Mútua de Terrassa, Terrassa, Barcelona, Spain) ; Krupinski, Jerzy (School of Healthcare Science, Manchester Metropolitan University, Manchester, United Kingdom) ; Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ; Universitat Autònoma de Barcelona
Oral anticoagulants (OAs) are the recommended drugs to prevent cardiovascular events and recurrence in patients with atrial fibrillation (AF) and cardioembolic stroke. We conducted a literature search to review the current state of OAs pharmacogenomics, focusing on Genome Wide Association Studies (GWAs) in patients treated with vitamin K antagonists (VKAs) and direct oral anticoagulants (DOACs). [...]
2018 - 10.18632/oncotarget.25579
Oncotarget, Vol. 9 (june 2018) , p. 29238-29258  
3.
8 p, 1.6 MB DNA methylation of MMPs and TIMPs in atherothrombosis process in carotid plaques and blood tissues / Gallego-Fabrega, Cristina (Institut d'Investigació Biomèdica Sant Pau) ; Cullell, Natalia (Institut d'Investigació Biomèdica Sant Pau) ; Soriano-Tárraga, Carolina (Institut Hospital del Mar d'Investigacions Mèdiques) ; Carrera, Caty (Institut d'Investigació Biomèdica Sant Pau) ; Torres-Aguila, Nuria P. (Institut d'Investigació Biomèdica Sant Pau) ; Muiño, Elena (Institut d'Investigació Biomèdica Sant Pau) ; Cárcel-Márquez, Jara (Institut d'Investigació Biomèdica Sant Pau) ; de Moura, Manuel Castro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Fernández-Sanlés, Alba (Institut Hospital del Mar d'Investigacions Mèdiques) ; Esteller, Manel (Institució Catalana de Recerca i Estudis Avançats (ICREA)) ; Elosua, Roberto (Institut Hospital del Mar d'Investigacions Mèdiques) ; Jiménez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ; Roquer, Jaume (Institut Hospital del Mar d'Investigacions Mèdiques) ; Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Krupinski, Jerzy ; Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ; Universitat Autònoma de Barcelona
Background and Purpose: Polymorphisms and serum levels of Matrix Metalloproteinases (MMP) and Tissue Inhibitor of Metalloproteinases (TIMP) have been studied with regard to atheromatous plaques and ischemic stroke, while no studies of DNA methylation (DNAm) patterns of MMP or TIMP have been performed to that end. [...]
2020 - 10.18632/oncotarget.27469
Oncotarget, Vol. 11 (march 2020) , p. 905-912  
4.
14 p, 236.7 KB Clinical Variables and Genetic Risk Factors Associated with the Acute Outcome of Ischemic Stroke : A Systematic Review / Torres-Aguila, Nuria P (Institut d'Investigació Biomèdica Sant Pau) ; Carrera, Caty (Institut d'Investigació Biomèdica Sant Pau) ; Muiño, Elena (Institut d'Investigació Biomèdica Sant Pau) ; Cullell, Natalia (Hospital Universitari MútuaTerrassa) ; Cárcel-Márquez, Jara (Institut d'Investigació Biomèdica Sant Pau) ; Gallego-Fabrega, Cristina (Institut d'Investigació Biomèdica Sant Pau) ; González-Sánchez, Jonathan (Institut d'Investigació Biomèdica Sant Pau) ; Bustamante, Alejandro (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Delgado Martínez, María Pilar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Ibañez, Laura (Department of Psychiatry, Washington University School of Medicine, St. Louis, MO) ; Heitsch, Laura (Department of Neurology, Washington University School of Medicine, St. Louis, MO) ; Krupinski, Jerzy (Health Care Science Department, The Manchester Metropolitan University of All Saints, Manchester) ; Montaner, Joan (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ; Martí-Fàbregas, Joan (Institut d'Investigació Biomèdica Sant Pau) ; Cruchaga, Carlos (Department of Psychiatry, Washington University School of Medicine, St. Louis, MO) ; Lee, Jin-Moo (Department of Neurology, Washington University School of Medicine, St. Louis, MO) ; Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ; Universitat Autònoma de Barcelona
Stroke is a complex disease and one of the main causes of morbidity and mortality among the adult population. A huge variety of factors is known to influence patient outcome, including demographic variables, comorbidities or genetics. [...]
2019 - 10.5853/jos.2019.01522
Journal of Stroke, Vol. 21 (september 2019) , p. 276-289  
5.
12 p, 544.9 KB Association of Apolipoprotein e with Intracerebral Hemorrhage Risk by Race/Ethnicity : A Meta-analysis / Marini, S. (Massachusetts General Hospital) ; Crawford, K. (Massachusetts General Hospital) ; Morotti, A. (Fondazione Mondino IRCCS, Pavia) ; Lee, M.J. (Massachusetts General Hospital) ; Pezzini, A. (Università degli Studi di Brescia) ; Moomaw, C.J. (University of Cincinnati) ; Flaherty, M.L. (University of Cincinnati) ; Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Roquer Gonzalez, Jaume (Institut Hospital del Mar d'Investigacions Mèdiques) ; Jimenez Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ; Giralt Steinhauer, Eva (Institut Hospital del Mar d'Investigacions Mèdiques) ; Elosua, Roberto (Institut Hospital del Mar d'Investigacions Mèdiques) ; Cuadrado-Godia, Elisa (Institut Hospital del Mar d'Investigacions Mèdiques) ; Soriano Tarraga, Carolina (Institut Hospital del Mar d'Investigacions Mèdiques) ; Slowik, A. (Jagiellonian University Medical College, Kraków) ; Jagiella, J.M. (Jagiellonian University Medical College, Kraków) ; Pera, J. (Jagiellonian University Medical College, Kraków) ; Urbanik, A. (Jagiellonian University Medical College, Kraków) ; Pichler, A. (Jagiellonian University Medical College, Kraków) ; Hansen, B.M. (Lund University) ; McCauley, J.L. (John P. Hussman Institute for Human Genomics, Miami) ; Tirschwell, D.L. (University of Washington) ; Selim, Magdy (Beth Israel Deaconess Medical Center, Boston) ; Brown, D.L. (University of Michigan) ; Silliman, S.L. (University of Florida College of Medicine) ; Worrall, B.B. (University of Virginia Health System) ; Meschia, J.F. (Mayo Clinic, Jacksonville, Florida) ; Kidwell, C.S. (University of Arizona) ; Testai, F.D. (University of Illinois) ; Kittner, S.J. (University of Maryland School of Medicine) ; Schmidt, H. (Medical University of Graz) ; Enzinger, C. (Medical University of Graz) ; Deary, I.J. (University of Edinburgh) ; Rannikmae, K. (University of Edinburgh) ; Samarasekera, N. (University of Edinburgh) ; Salman, R.A.S. (University of Edinburgh) ; Sudlow, C.L. (University of Edinburgh) ; Klijn, C.J.M. (UMC Utrecht Brain Center Rudolf Magnus) ; Van Nieuwenhuizen, K.M. (UMC Utrecht Brain Center Rudolf Magnus) ; Fernandez Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ; Delgado Martínez, María Pilar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Norrving, B. (Lund University) ; Lindgren, A. (Lund University) ; Goldstein, J.N. (Massachusetts General Hospital) ; Viswanathan, A. (Massachusetts General Hospital) ; Greenberg, S.M. (Massachusetts General Hospital) ; Falcone, G.J. (Yale University) ; Biffi, A. (Massachusetts General Hospital) ; Langefeld, C.D. (Wake Forest University, Winston-Salem, North Carolina) ; Woo, D. (University of Cincinnati College of Medicine) ; Rosand, J. (Massachusetts General Hospital) ; Anderson, C.D. (Massachusetts General Hospital) ; Universitat Autònoma de Barcelona
Importance: Genetic studies of intracerebral hemorrhage (ICH) have focused mainly on white participants, but genetic risk may vary or could be concealed by differing nongenetic coexposures in nonwhite populations. [...]
2019 - 10.1001/jamaneurol.2018.4519
JAMA Neurology, Vol. 76 Núm. 4 (april 2019) , p. 480-491  
6.
15 p, 517.3 KB GRECOS project (Genotyping Recurrence Risk of Stroke). The use of genetics to predict the vascular recurrence after stroke / Fernández Cadenas, Israel (Hospital Universitari Vall d'Hebron) ; Mendióroz, Maite (Hospital Universitari Vall d'Hebron) ; Giralt, Dolors (Hospital Universitari Vall d'Hebron) ; Nafría, Cristina (Hospital Universitari Vall d'Hebron) ; Garcia, Elena (Fundació Docència i Recerca Mutua Terrassa) ; Carrera, Caty (Hospital Universitari Vall d'Hebron) ; Gallego-Fabrega, Cristina (Fundació Docència i Recerca Mutua Terrassa) ; Domingues-Montanari, Sophie (Hospital Universitari Vall d'Hebron) ; Delgado Martínez, María Pilar (Hospital Universitari Vall d'Hebron) ; Ribó, Marc (Hospital Universitari Vall d'Hebron) ; Castellanos, Mar (Hospital Universitari de Girona Doctor Josep Trueta) ; Martínez, Sergi (Institut d'Investigació Biomèdica Sant Pau) ; Freijo, Mari Mar (Hospital de Basurto. Departamento de Neurologia) ; Jiménez-Conde, Jordi (Hospital del Mar (Barcelona, Catalunya)) ; Rubiera, Marta (Hospital Universitari Vall d'Hebron) ; Alvarez Sabín, José (Hospital Universitari Vall d'Hebron) ; Molina, Carlos A. (Hospital Universitari Vall d'Hebron) ; Font, Maria Angels (Hospital Universitari de Bellvitge) ; Grau Olivares, Marta (Hospital Universitari Sagrat Cor. Departament de Neurologia) ; Palomeras, Ernest (Hospital de Mataró. Departament de Neurologia) ; Perez de la Ossa, Natalia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Martinez Zabaleta, Maite (Hospital Donostia. Departamento de Neurologia) ; Masjuan, Jaime (Hospital Ramón y Cajal) ; Moniche, Francisco (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ; Canovas, David (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ; Piñana, Carlos (Hospital Universitario Virgen de las Nieves. Departamento de Neurologia) ; Purroy, Francisco (Hospital Universitari Arnau de Vilanova. Departament de Neurologia) ; Cocho, Dolores (Hospital General de Granollers) ; Navas, Inma (Hospital Universitari MútuaTerrassa) ; Tejero, Carlos (Hospital Clínico Universitario "Lozano Blesa" de Zaragoza) ; Aymerich, Nuria (Hospital de Navarra. Departamento de Neurologia) ; Cullell, Natalia (Fundació Docència i Recerca Mutua Terrassa) ; Muiño, Elena (Fundació Docència i Recerca Mutua Terrassa) ; Serena, Joaquín (Hospital Universitari de Girona Doctor Josep Trueta) ; Rubio, Francisco (Hospital Universitari de Bellvitge) ; Davalos, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Roquer González, Jaume (Hospital del Mar (Barcelona, Catalunya)) ; Arenillas, Juan F (Hospital Clínico Universitario (Valladolid)) ; Martí Fábregas, Joan (Institut d'Investigació Biomèdica Sant Pau) ; Keene, Keith (Center for Health Disparities. East Carolina University) ; Chen, Wei-Min (Department of Public Health Sciences; Center for Public Health Genomics, University of Virginia) ; Worrall, Bradford (Department of Neurology; Department of Public Health Sciences, University of Virginia) ; Sale, Michele (Center for Public Health Genomics, University of Virginia) ; Arboix, Adrià (Hospital Universitari Sagrat Cor. Departament de Neurologia) ; Krupinski, Jerzy (Hospital Universitari MútuaTerrassa) ; Montaner, Joan (Hospital Universitari Vall d'Hebron) ; GRECOSstudy group ; Universitat Autònoma de Barcelona
Background and Purpose-Vascular recurrence occurs in 11% of patients during the first year after ischemic stroke (IS) or transient ischemic attack (TIA). Clinical scores do not predict the whole vascular recurrence risk, therefore we aimed to find genetic variants associated with recurrence that might improve the clinical predictive mode is in IS. [...]
2017 - 10.1161/STROKEAHA.116.014322
Stroke, Vol. 48 Núm. 5 (2017) , p. 1147-1153  
7.
5 p, 280.6 KB DNA Methylation in Stroke. Update of Latest Advances / Krupinski, Jerzy (School of Healthcare Science, Manchester Metropolitan University, Manchester, United Kingdom) ; Carrera, Caty (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Muiño, Elena (Stroke Pharmacogenomics and Genetics, Fundació Docència i Recerca Mutua Terrassa, Hospital Universitari Mútua de Terrassa, Terrassa, Barcelona, Spain) ; Torres, Nuria (Stroke Pharmacogenomics and Genetics, Fundació Docència i Recerca Mutua Terrassa, Hospital Universitari Mútua de Terrassa, Terrassa, Barcelona, Spain) ; Al-Baradie, Raid (Applied Medical Sciences College Majmaah University, Majmaah, Saudi Arabia) ; Cullell, Natalia (Stroke Pharmacogenomics and Genetics, Fundació Docència i Recerca Mutua Terrassa, Hospital Universitari Mútua de Terrassa, Terrassa, Barcelona, Spain) ; Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ; Universitat Autònoma de Barcelona
Epigenetic modifications are hereditable and modifiable factors that do not alter the DNA sequence. These epigenetic factors include DNA methylation, acetylation of histones and non-coding RNAs. Epigenetic factors have mainly been associated with cancer but also with other diseases and conditions such as diabetes or obesity. [...]
2017 - 10.1016/j.csbj.2017.12.001
Computational and Structural Biotechnology Journal, Vol. 16 (december 2017) , p. 1-5  
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8 p, 2.3 MB Automated quantification of cerebral edema following hemispheric infarction : Application of a machine-learning algorithm to evaluate CSF shifts on serial head CTs / Chen, Yasheng (Department of Neurology, Washington University, St. Louis, MO 63110, USA) ; Dhar, Rajat (Department of Neurology, Washington University, St. Louis, MO 63110, USA) ; Heitsch, Laura (Emergency Medicine, Washington University, St. Louis, MO 63110, USA) ; Ford, Andria (Department of Neurology, Washington University, St. Louis, MO 63110, USA) ; Fernandez-Cadenas, Israel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Carrera, Caty (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Lin, Weili (Dept. of Radiology, University of North Carolina, Chapel Hill, NC 27599, USA) ; Shen, Dinggang (Department of Brain and Cognitive Engineering, Korea University, Seoul 02841, Republic of Korea) ; An, Hongyu (Radiology, Washington University, St. Louis, MO 63110, USA) ; Lee, Jin-Moo (Biomedical Engineering, Washington University, St. Louis, MO 63110, USA) ; Universitat Autònoma de Barcelona
Although cerebral edema is a major cause of death and deterioration following hemispheric stroke, there remains no validated biomarker that captures the full spectrum of this critical complication. We recently demonstrated that reduction in intracranial cerebrospinal fluid (CSF) volume (∆ CSF) on serial computed tomography (CT) scans provides an accurate measure of cerebral edema severity, which may aid in early triaging of stroke patients for craniectomy. [...]
2016 - 10.1016/j.nicl.2016.09.018
NeuroImage, Vol. 12 (september 2016) , p. 673-680  
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11 p, 168.8 KB Genetic variants in CETP increase risk of intracerebral hemorrhage / Anderson, Christopher D. (Broad Institute of MIT and Harvard) ; Falcone, Guido J. (Departments of Epidemiology and Biostatistics, Harvard T. H. Chan School of Public Health) ; Phuah, Chia-Ling (Broad Institute of MIT and Harvard) ; Radmanesh, Farid (Broad Institute of MIT and Harvard) ; Brouwers, H. Bart (Broad Institute of MIT and Harvard) ; Battey, Thomas W. K. (Broad Institute of MIT and Harvard) ; Biffi, Alessandro (Division of Psychiatry, Department of Psychiatry, MGH) ; Peloso, Gina M. (Broad Institute of MIT and Harvard) ; Liu, Dajiang J. (Institute of Personalized Medicine, Penn State College of Medicine) ; Ayres, Alison M. (J. Philip Kistler Stroke Research Center, Department of Neurology, MGH) ; Goldstein, Joshua N. (Department of Emergency Medicine, MGH) ; Viswanathan, Anand (J. Philip Kistler Stroke Research Center, Department of Neurology, MGH) ; Greenberg, Steven M. (J. Philip Kistler Stroke Research Center, Department of Neurology, MGH) ; Selim, Magdy (Beth Israel Deaconess Medical Center) ; Meschia, James F. (Mayo Clinic) ; Brown, Devin L. (University of Michigan Health System) ; Worrall, Bradford B. (University of Virginia Health System) ; Silliman, Scott L. (University of Florida College of Medicine) ; Tirschwell, David L. (University of Washington) ; Flaherty, Matthew L. (University of Cincinnati College of Medicine) ; Kraft, Peter (Departments of Epidemiology and Biostatistics, Harvard T. H. Chan School of Public Health) ; Jagiella, Jeremiasz M. (Jagiellonian University Medical College) ; Schmidt, Helena (Medical University Graz) ; Hansen, Björn M. (Skåne University Hospital) ; Jimenez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ; Giralt Steinhauer, Eva (Institut Hospital del Mar d'Investigacions Mèdiques) ; Elosua, Roberto (Institut Hospital del Mar d'Investigacions Mèdiques) ; Cuadrado-Godia, Elisa (Institut Hospital del Mar d'Investigacions Mèdiques) ; Soriano Tàrraga, Carolina (Institut Hospital del Mar d'Investigacions Mèdiques) ; van Nieuwenhuizen, Koen M. (University Medical Center Utrecht) ; Klijn, Catharina J. M. (Donders Institute for Brain, Cognition, and Behavior, Radboud University Medical Center) ; Rannikmae, Kristiina (University of Edinburgh) ; Samarasekera, Neshika (University of Edinburgh) ; Salman, Rustam Al-Shahi (University of Edinburgh) ; Sudlow, Catherine L. (University of Edinburgh) ; Deary, Ian J. (University of Edinburgh) ; Morotti, Andrea (Neurology Clinic, University of Brescia) ; Pezzini, Alessandro (Neurology Clinic, University of Brescia) ; Pera, Joanna (Jagiellonian University Medical College) ; Urbanik, Andrzej (Jagiellonian University Medical College) ; Pichler, Alexander (Medical University of Graz) ; Enzinger, Christian (Medical University of Graz) ; Norrving, Bo (Skåne University Hospital) ; Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Fernandez-Cadenas, Israel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Delgado Martínez, Pilar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Roquer González, Jaume (Institut Hospital del Mar d'Investigacions Mèdiques) ; Lindgren, Arne (Skåne University Hospital) ; Slowik, Agnieszka (Jagiellonian University Medical College) ; Schmidt, Reinhold (Medical University of Graz) ; Kidwell, Chelsea S. (University of Arizona) ; Kittner, Steven J. (Baltimore Veterans Administration Medical Center and University of Maryland School of Medicine) ; Waddy, Salina P. (National Institutes of Health) ; Langefeld, Carl D. (Wake Forest University) ; Abecasis, Goncalo (University of Michigan School of Public Health) ; Willer, Cristen J. (University of Michigan Medical School) ; Kathiresan, Sekar (Cardiovascular Disease Prevention Center, MGH) ; Woo, Daniel (University of Cincinnati College of Medicine) ; Rosand, Jonathan (Broad Institute of MIT and Harvard) ; Universitat Autònoma de Barcelona. Departament de Neurologia
In observational epidemiologic studies, higher plasma high-density lipoprotein cholesterol (HDL-C) has been associated with increased risk of intracerebral hemorrhage (ICH). DNA sequence variants that decrease cholesteryl ester transfer protein (CETP) gene activity increase plasma HDL-C; as such, medicines that inhibit CETP and raise HDL-C are in clinical development. [...]
2016 - 10.1002/ana.24780
Annals of Neurology, Vol. 80 (october 2016) , p. 730-740  
10.
7 p, 539.4 KB An Inflammatory Polymorphisms Risk Scoring System for the Differentiation of Ischemic Stroke Subtypes / Muiño, Elena (Fundació Docència i Recerca Mútua Terrassa) ; Krupinski, Jurek (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ; Carrera, Caty (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Gallego-Fabrega, Cristina (Fundació Docència i Recerca Mútua Terrassa) ; Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Fernández-Cadenas, Israel (Fundació Docència i Recerca Mútua Terrassa) ; Universitat Autònoma de Barcelona
Inflammation has been associated with atherothrombotic stroke and recently with cardioembolic stroke. Different genetic risk factors have been specifically associated with the subtypes of ischemic stroke (cardioembolic, atherothrombotic, and lacunar). [...]
2015 - 10.1155/2015/569714
Mediators of Inflammation, Vol. 2015 (august 2015)  

Artículos : Encontrados 16 registros   1 - 10siguiente  ir al registro:
Documentos de investigación Encontrados 3 registros  
1.
184 p, 4.5 MB Análisis de la etiopatogenia del cadasil mediante estudios transcriptómicos y estimación del pronóstico tras el ictus isquémico en el cadasil / Muiño Acuña, Elena ; Fernández Cadenas, Israel, dir. ; Roquer González, Jaume, dir. ; Montaner Villalonga, Joan, dir. ; Universitat Autònoma de Barcelona. Departament de Medicina
El CADASIL és una arteriopatia sistèmica causada per mutacions en NOTCH3, que afecten el nombre de cisteïnes del domini extracel·lular del receptor, alterant els ponts disulfur i propiciant un mal plegament d'aquest, i la seva agregació juntament amb la d'altres proteïnes; mecanisme que actualment es considera responsable de la malaltia. [...]
El CADASIL es una arteriopatía sistémica causada por mutaciones en NOTCH3, que afectan al número de cisteínas del dominio extracelular del receptor, alterando los puentes disulfuro y propiciando un mal plegamiento de este, y su agregación junto con la de otras proteínas; mecanismo que actualmente se considera responsable de la enfermedad. [...]
CADASIL is a systemic artery disease caused by mutations in NOTCH3, which affect the number of cysteines in the extracellular domain of the receptor, altering the disulfide bridges and causing a missfolding of the receptor, and its aggregation along with other proteins; a mechanism currently considered responsible for the disease. [...]

2020  
2.
366 p, 5.6 MB Genètica aplicada a la clínica neurovascular / Río Espínola, Alberto del ; Fernández Cadenas, Israel, dir. ; Montaner, Joan, dir. ; Álvarez Sabín, J., (José) dir. ; Universitat Autònoma de Barcelona. Departament de Medicina
En aquesta tesi doctoral es descriuen els resultats de l'estudi farmacogenètic Geno-tPA, en el qual es va analitzar el paper de centenars de polimorfismes (SNPs) en la resposta al tractament trombolític de l'ictus isquèmic: recanalització arterial una hora després de la infusió, reoclusión arterial després d'haver recanalitzar, aparició de transformació hemorràgica iatrogènica i mortalitat intrahospitalària. [...]
This thesis describes the results of the Geno-tPA pharmacogenetic study, which analyzed the role of hundreds of polymorphisms (SNPs) in the response to thrombolytic treatmentof ischemic stroke: recanalization one hour after t-PA infusion, arterial reocclusion of the recanalized artery, presence of iatrogenic hemorrhagic transformation and in-hospital mortality. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2011  
3.
207 p, 5.4 MB Identificación y uso de biomarcadores pronósticos en el ictus isquémico / García Berrocoso, Teresa ; Montaner, Joan, dir. ; Fernández Cadenas, Israel, dir. ; Delgado Martínez, Pilar, dir. ; Garcia-Dorado, David ; Universitat Autònoma de Barcelona. Departament d'Antropologia Social i Cultural
El ictus es una enfermedad con una elevada morbimortalidad, suponiendo la segunda causa de muerte a nivel mundial y una de las principales causas de discapacidad en el adulto. Aun así, la heterogeneidad entre los pacientes con ictus dificulta anticipar el pronóstico de la enfermedad. [...]
Stroke is a severe disease, being the second cause of death worldwide and one of the main causes of disability. Heterogeneity among stroke patients makes difficult to anticipate the prognosis of the disease. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2014  

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