Home > Search Results: Fernández Fleischhauer, Daniel
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Results overview: Found 3 records in 0.02 seconds.
Articles, 2 records found
Research literature, 1 records found
Articles 2 records found  
1.
8 p, 935.8 KB Structural and Functional Analysis of the Complex between Citrate and the Zinc Peptidase Carboxypeptidase A / Fernández Fleischhauer, Daniel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Boix i Borràs, Esther (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Pallarès i Goitiz, Irantzu (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Avilés, Francesc X. (Francesc Xavier) (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Vendrell i Roca, Josep (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí"
A high-resolution carboxypeptidase-Zn 2+ -citrate complex was studied by X-ray diffraction and enzyme kinetics for the first time. The citrate molecule acts as a competitive inhibitor of this benchmark zinc-dependent peptidase, chelating the catalytic zinc ion in the active site of the enzyme and inducing a conformational change such that carboxypeptidase adopts the conformation expected to occur by substrate binding. [...]
2011 - 10.4061/2011/128676
Enzyme research, Vol. 2011 (July 2011) , art. 128676  
Detailed record - Creative Commons
2.
8 p, 1.0 MB Direct interaction between a human digestive protease and the mucoadhesive poly(acrylic acid) / Pallarès i Goitiz, Irantzu (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Fernández Fleischhauer, Daniel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Comellas-Bigler, Mireia (Max-Planck Institute of Biochemistry. Proteinase Research Group) ; Fernández-Recio, Juan (Barcelona Supercomputing Center) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Avilés, Francesc X. (Francesc Xavier) (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Bode, Wolfram (Max-Planck Institute of Biochemistry. Proteinase Research Group) ; Vendrell i Roca, Josep (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Carboxypeptidase A1 has been the subject of extensive research in the last 30 y and is one of the most widely studied zinc metalloenzymes. However, the three-dimensional structure of the human form of the enzyme is not yet available. [...]
2008 - 10.1107/S0907444908013474
Acta crystallographica. Section D, Biological crystallography, Vol. 64, Issue 7 (July 2008) , p. 784-791  
Detailed record -

Research literature 1 records found  
1.
232 p, 2.9 MB Discovery and characterizatopn of small molecular weight metallocarboxypeptidase inhibitors / Fernández Fleischhauer, Daniel ; Avilés, Francesc X. (Francesc Xavier) (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Vendrell i Roca, Josep, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
Las hidrolasas son enzimas que catalizan la ruptura del enlace amida o peptódico, y por lo tanto son denominadas también proteasas o peptidasas. Las proteasas constituyen cerca del 2 % del genoma humano, lo que representa unos 600 productos génicos. [...]
Hydrolases are enzymes catalyzing the breakdown of the amide or peptide bond, and are therefore called proteases or peptidases as well. In the human genome, proteases made up about 2% of the genome, or about 600 gene products. [...]
Bellaterra: Universitat Autònoma de Barcelona, 2010  
Detailed record -

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