Resultats globals: 12 registres trobats en 0.02 segons.
Articles, 11 registres trobats
Documents de recerca, 1 registres trobats
Articles 11 registres trobats  1 - 10següent  anar al registre:
1.
15 p, 3.8 MB Dense core vesicle markers in CSF and cortical tissues of patients with Alzheimer's disease / Barranco, Neus (Universitat de Barcelona. Institut de Neurociències) ; Plá, Virginia (University of Rochester Medical Center) ; Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ; Sánchez-Domínguez, Irene (Universitat de Barcelona) ; Fischer-Colbrie, Reiner (Innsbruck Medical University) ; Ferrer, Isidro (Institut d'Investigació Biomèdica de Bellvitge) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Aguado, Fernando (Universitat de Barcelona) ; Universitat Autònoma de Barcelona
New fluid biomarkers for Alzheimer's disease (AD) that reveal synaptic and neural network dysfunctions are needed for clinical practice and therapeutic trial design. Dense core vesicle (DCV) cargos are promising cerebrospinal fluid (CSF) indicators of synaptic failure in AD patients. [...]
2021 - 10.1186/s40035-021-00263-0
Translational Neurodegeneration, Vol. 10 (september 2021)  
2.
19 p, 6.1 MB TREM2 expression in the brain and biological fluids in prion diseases / Diaz-Lucena, Daniela (Institut d'Investigació Biomèdica de Bellvitge) ; Kruse, Niels (University Medical Center Göttingen. Institute of Neuropathology) ; Thüne, Katrin (University Medical Center Göttingen. Department of Neurology) ; Schmitz, Matthias (German Center for Neurodegenerative Diseases) ; Villar-Piqué, Anna (Institut d'Investigació Biomèdica de Bellvitge) ; da Cunha, Jose Eriton Gomes (Universidade Federal de Pernambuco. Keizo Asami Laboratory) ; Hermann, Peter (University Medical Center Göttingen. Department of Neurology) ; López-Pérez, Óscar (Institut d'Investigació Biomèdica de Bellvitge) ; Andrés-Benito, Pol (Institut d'Investigació Biomèdica de Bellvitge) ; Ladogana, Anna (Istituto Superiore Di Sanità. Department of Neurosciences) ; Calero, Miguel (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Vidal Barba, Enric (Institut de Recerca i Tecnologia Agroalimentàries) ; Riggert, Joachim (University Medical School. Department of Transfusion Medicine) ; Pineau, Hailey (University of Alberta. Department of Medicine-Division of Neurology) ; Sim, Valerie (University of Alberta. Department of Medicine-Division of Neurology) ; Zetterberg, Henrik (UCL Institute of Neurology.) ; Blennow, Kaj (Sahlgrenska University Hospital. Clinical Neurochemistry Laboratory) ; del Río, Jose Antonio (University of Barcelona. Institute of Neuroscience) ; Marín-Moreno, Alba (Centro de Investigación en Sanidad Animal. CISA-INIA) ; Espinosa, Juan Carlos (Centro de Investigación en Sanidad Animal. CISA-INIA) ; Torres, Juan María (Centro de Investigación en Sanidad Animal. CISA-INIA) ; Sánchez-Valle, Raquel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Mollenhauer, Brit (University Medical Centre Göttingen. Department of Neurology) ; Ferrer, Isidro (Universitat de Barcelona. Departament de Patologia i Terapèutica Experimental) ; Zerr, Inga (German Center for Neurodegenerative Diseases) ; Llorens, Franc (University Medical Center Göttingen. Department of Neurology)
Triggering receptor expressed on myeloid cells 2 (TREM2) is an innate immune cell surface receptor that regulates microglial function and is involved in the pathophysiology of several neurodegenerative diseases. [...]
2021 - 10.1007/s00401-021-02296-1
Acta Neuropathologica, Vol. 141 (april 2021) , p. 841-859  
3.
12 p, 3.3 MB Poly(propylene imine) dendrimers with histidine-maltose shell as novel type of nanoparticles for synapse and memory protection / Aso, Ester (ALBA Laboratori de Llum de Sincrotró) ; Martinsson, Isak (Wallenberg Neuroscience Center) ; Appelhans, Dietmar (Leibniz Institute of Polymer Research Dresden) ; Effenberg, Christiane (Leibniz Institute of Polymer Research Dresden) ; Benseny Cases, Núria (ALBA Laboratori de Llum de Sincrotró) ; Cladera i Cerdà, Josep (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Gouras, Gunnar (Wallenberg Neuroscience Center) ; Ferrer, Isidro (Hospital Universitari de Bellvitge) ; Klementieva, Oxana (Wallenberg Neuroscience Center)
Poly(propylene imine) dendrimers have been shown to be promising 3-dimensional polymers for the use in the pharmaceutical and biomedical applications. Our aims of this study were first, to synthesize a novel type of dendrimer with poly(propylene imine) core and maltose-histidine shell (G4HisMal) assessing if maltose-histidine shell can improve the biocompatibility and the ability to cross the blood-brain barrier, and second, to investigate the potential of G4HisMal to protect Alzheimer disease transgenic mice from memory impairment. [...]
2019 - 10.1016/j.nano.2019.01.010
Nanomedicine, Vol. 17 (April 2019) , p. 198-209  
4.
14 p, 2.6 MB Myoglobinopathy is an adult-onset autosomal dominant myopathy with characteristic sarcoplasmic inclusions / Olivé, Montserrat (Institut d'Investigació Biomèdica de Bellvitge) ; Engvall, Martin (Karolinska University Hospital) ; Ravenscroft, Gianina (University of Western Australia. Harry Perkins Institute of Medical Research) ; Cabrera Serrano, Macarena (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ; Jiao, H. (Karolinska University Hospital) ; Bortolotti, Carlo Augusto (University of Modena and Reggio Emilia) ; Pignataro, Marcello (University of Modena and Reggio Emilia) ; Lambrughi, M. (University of Modena and Reggio Emilia) ; Jiang, H. (The University of Western Australia) ; Forrest, A.R.R. (University of Western Australia. Harry Perkins Institute of Medical Research) ; Benseny Cases, Núria (ALBA Laboratori de Llum de Sincrotró) ; Hofbauer, Stefan (BOKU-University of Natural Resources and Life Sciences) ; Obinger, Christian (BOKU-University of Natural Resources and Life Sciences) ; Battistuzzi, G. (University of Modena and Reggio Emilia) ; Bellei, M. (University of Modena and Reggio Emilia) ; Borsari, Marco (University of Modena and Reggio Emilia) ; Di Rocco, G. (University of Modena and Reggio Emilia) ; Viola, H.M. (The University of Western Australia) ; Hool, L.C. (Victor Chang Cardiac Research Institute) ; Cladera i Cerdà, Josep (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Lagerstedt-Robinson, K. (Karolinska University Hospital. Solna) ; Xiang, F. (Karolinska Institutet (Estocolm, Suècia)) ; Wredenberg, A. (Karolinska Institutet (Estocolm, Suècia)) ; Miralles, Francesc (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ; Baiges, J.J. (Hospital Verge de la Cinta) ; Malfatti, E. (Centre de Référence de Pathologie Neuromusculaire Paris-Est) ; Romero, N.B. (Centre de Référence de Pathologie Neuromusculaire Paris-Est) ; Streichenberger, N. (Université Claude Bernard Lyon) ; Vial, C. (Electromyographie-Groupement Hospitalier Est) ; Claeys, K.G. (KU Leuven-University of Leuven) ; Straathof, C.S.M. (Leiden University Medical Center) ; Goris, A. (KU Leuven-University of Leuven) ; Freyer, C. (Karolinska Institutet (Estocolm, Suècia)) ; Lammens, M. (Radboud University Medical Center) ; Bassez, G. (East-Paris University (UPEC)) ; Kere, J. (King's College London) ; Clemente, P. (Karolinska Institutet (Estocolm, Suècia)) ; Sejersen, Thomas (Karolinska Institutet (Estocolm, Suècia)) ; Udd, B. (Tampere University Hospital) ; Vidal, Noemí (Institut d'Investigació Biomèdica de Bellvitge) ; Ferrer, Isidro (Universitat de Barcelona) ; Edström, L. (Karolinska Institutet (Estocolm, Suècia)) ; Wedell, A. (Karolinska University Hospital) ; Laing, N.G. (University of Western Australia. Harry Perkins Institute of Medical Research)
Myoglobin, encoded by MB, is a small cytoplasmic globular hemoprotein highly expressed in cardiac myocytes and oxidative skeletal myofibers. Myoglobin binds O facilitates its intracellular transport and serves as a controller of nitric oxide and reactive oxygen species. [...]
2019 - 10.1038/s41467-019-09111-2
Nature communications, Vol. 10 (March 2019) , art. 1396  
5.
2 p, 188.6 KB Synthesis, in vitro profiling, and in vivo efficacy studies of a new family of multitarget antiAlzheimer compounds / Pérez-Areales, Francisco Javier (Universitat de Barcelona) ; Garrido, María (Instituto de Química Avanzada de) ; Catalunya (IQAC-CSIC) ; Aso, Ester (Universitat de Barcelona) ; Bartolini, Manuela (Department of Pharmacy and Biotechnology. Alma Mater Studiorum University of Bologna) ; De Simone, Angela (University of Bologna. Department for Life Quality Studies) ; Espargaró Colomé, Alba (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Ginex, Tiziana (Universitat de Barcelona) ; Sabate, Raimon (Universitat de Barcelona) ; Pérez, Belén (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ; Andrisano, Vincenza (University of Bologna. Department for Life Quality Studies) ; Luque, Francisco Javier (Universitat de Barcelona) ; Ferrer, Isidro (Universitat de Barcelona. Unitat de Neuropatologia Experimental) ; Ciruela, Francisco (Universitat de Barcelona) ; Messeguer, Àngel (Instituto de Química Avanzada de) ; Catalunya (IQAC-CSIC) ; Muñoz-Torrero López-Ibarra, Diego (Universitat de Barcelona. Laboratori de Química Farmacèutica)
Simultaneous modulation of several targets or athological events with a key pathogenic role is a promising strategy to tackle thus far difficult-to-cure or incurable multifactorial diseases, such as Alzheimer's disease (AD). [...]
2019 - 10.3390/proceedings2019022071
Proceedings, Vol. 22 (2019) , p. 1-2  
6.
14 p, 17.9 MB Involvement of Cellular Prion Protein in α-Synuclein Transport in Neurons / Urrea, Laura (Universitat de Barcelona) ; Segura-Feliu, Miriam (Universitat de Barcelona) ; Masuda-Suzukake, Masami (Metropolitan Institute of Medical Science (Setagaya-ku, Tokyo)) ; Hervera Abad, Arnau (Universitat de Barcelona) ; Pedraz, Lucas (Institute for Bioengineering of Catalonia) ; García Aznar, José Manuel (Universidad de Zaragoza) ; Vila Bover, Miquel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Samitier, Josep (Universitat de Barcelona) ; Torrents, Eduard (Institute for Bioengineering of Catalonia) ; Ferrer, Isidro (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Gavín, Rosalina (Universitat de Barcelona) ; Hagesawa, Masato (Metropolitan Institute of Medical Science (Setagaya-ku, Tokyo)) ; del Río, José Antonio (Universitat de Barcelona) ; Universitat Autònoma de Barcelona
The cellular prion protein, encoded by the gene Prnp, has been reported to be a receptor of β-amyloid. Their interaction is mandatory for neurotoxic effects of βamyloid oligomers. In this study, we aimed to explore whether the cellular prion protein participates in the spreading of α-synuclein. [...]
2017 - 10.1007/s12035-017-0451-4
Molecular neurobiology, Vol. 55 (february 2017) , p. 1847-1860  
7.
19 p, 8.9 MB Tauroursodeoxycholic bile acid arrests axonal degeneration by inhibiting the unfolded protein response in X-linked adrenoleukodystrophy / Launay, Nathalie (CIBERER U759, Center for Biomedical Research on Rare Diseases, Barcelona, Spain) ; Ruiz, Montserrat (CIBERER U759, Center for Biomedical Research on Rare Diseases, Barcelona, Spain) ; Grau, Laia (CIBERER U759, Center for Biomedical Research on Rare Diseases, Barcelona, Spain) ; Ortega, Francisco J. (CIBERER U759, Center for Biomedical Research on Rare Diseases, Barcelona, Spain) ; Ilieva, Ekaterina V. (Global data, London, UK) ; Martínez, Juan José (CIBERER U759, Center for Biomedical Research on Rare Diseases, Barcelona, Spain) ; Galea, Elena (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Ferrer, Isidro (CIBERNED, Center for Biomedical Research on Neurodegenerative Diseases, Barcelona, Spain) ; Knecht, Erwin (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Pujol, Aurora (CIBERER U759, Center for Biomedical Research on Rare Diseases, Barcelona, Spain) ; Fourcade, Stéphane (CIBERER U759, Center for Biomedical Research on Rare Diseases, Barcelona, Spain)
The online version of this article (doi:10. 1007/s00401-016-1655-9) contains supplementary material, which is available to authorized users.
2016 - 10.1007/s00401-016-1655-9
Acta Neuropathologica, Vol. 133 (december 2016) , p. 283-301  
8.
13 p, 663.0 KB Distinct patterns of APP processing in the CNS in autosomal-dominant and sporadic Alzheimer disease / Pera, Marta (Institut d'Investigació Biomèdica Sant Pau) ; Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ; Sánchez-Valle, Raquel (Hospital Clínic i Provincial de Barcelona) ; Guardia-Laguarta, Cristina (Institut d'Investigació Biomèdica Sant Pau) ; Colom-Cadena, Martí (Institut d'Investigació Biomèdica Sant Pau) ; Badiola Benito, Nahuai (Institut d'Investigació Biomèdica Sant Pau) ; Suárez-Calvet, Marc (Institut d'Investigació Biomèdica Sant Pau) ; Lladó, Albert (Hospital Clínic i Provincial de Barcelona) ; Barrera-Ocampo, Alvaro A. (Grupo de Neurociencias de Antioquia, Faculty of Medicine, University of Antioquia, Medellín, Colombia) ; Sepulveda-Falla, Diego (Grupo de Neurociencias de Antioquia, Faculty of Medicine, University of Antioquia, Medellín, Colombia) ; Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ; Molinuevo, José L. (Hospital Clínic i Provincial de Barcelona) ; Clarimón, Jordi (Institut d'Investigació Biomèdica Sant Pau) ; Ferrer, Isidro (Institut d'Investigació Biomèdica de Bellvitge) ; Gelpi, Ellen (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Universitat Autònoma de Barcelona
The online version of this article (doi:10. 1007/s00401-012-1062-9) contains supplementary material, which is available to authorized users.
2012 - 10.1007/s00401-012-1062-9
Acta Neuropathologica, Vol. 125 (december 2012) , p. 201-213  
9.
9 p, 525.8 KB Reduced ubiquitin C-terminal hydrolase-1 expression levels in dementia with Lewy bodies / Barrachina, Marta (Hospital Universitari de Bellvitge) ; Castaño, Esther (Universitat de Barcelona. Unitat de Biologia) ; Dalfo Capella, Esther (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Maes, Tamara (Parc Científic de Barcelona. Oryzon Genomics) ; Buesa, Carlos (Universitat de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Ferrer, Isidro (Universitat de Barcelona. Unitat de Neuropatologia Experimental)
Parkinson disease (PD) and dementia with Lewy bodies (DLB) are characterized by the accumulation of abnormal α-synuclein and ubiquitin in protein aggregates conforming Lewy bodies and Lewy neurites. [...]
2006 - 10.1016/j.nbd.2005.11.005
Neurobiology of disease, Vol. 22, Num. 2 (2006) , p. 265-73  
10.
16 p, 1020.6 KB Transgenic mice overexpressing the full-length neurotrophin receptor TrkC exhibit increased catecholaminergic neuron density in specific brain areas and increased anxiety-like behavior and panic reaction / Dierssen, Mara (Biomedical Research Park. Genes and Disease Program, Genomic Regulation Center) ; Gratacòs i Mayora, Mònica (Biomedical Research Park. Genes and Disease Program, Genomic Regulation Center) ; Sahún, Ignasi (Biomedical Research Park. Genes and Disease Program, Genomic Regulation Center) ; Martín, Miguel (Universitat Pompeu Fabra. Àrea de Neurofarmacologia) ; Gallego, Xavier (Biomedical Research Park. Genes and Disease Program, Genomic Regulation Center) ; Amador-Arjona, Alehandro (Biomedical Research Park. Genes and Disease Program, Genomic Regulation Center) ; Martínez de Lagrán María (Biomedical Research Park. Genes and Disease Program, Genomic Regulation Center) ; Murtra, Patricia (Universitat Pompeu Fabra. Àrea de Neurofarmacologia) ; Martí, Eulalia (Biomedical Research Park. Genes and Disease Program, Genomic Regulation Center) ; Pujana, Miguel A. (Biomedical Research Park. Genes and Disease Program, Genomic Regulation Center) ; Ferrer, Isidro (Hospital Prínceps d'Espanya. Àrea de neuropatologia) ; Dalfo Capella, Esther (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Martínez-Cué, Carmen (Universidad de Cantabria. Departamento de Psicologia y Farmacologia) ; Flórez, Jesús (Universidad de Cantabria. Departamento de Psicologia y Farmacologia) ; Torres-Peraza, Jesús F. (Universitat de Barcelona. Departament de Biologia Cel·lular i Anatomia Patològica) ; Alberch i Vié, Jordi (Universitat de Barcelona. Departament de Biologia Cel·lular i Anatomia Patològica) ; Maldonado, Rafael (Universitat Pompeu Fabra. Àrea de Neurofarmacologia) ; Fillat, Cristina (Biomedical Research Park. Genes and Disease Program, Genomic Regulation Center) ; Estivill, Xavier (Biomedical Research Park. Genes and Disease Program, Genomic Regulation Center)
Accumulating evidence has suggested that neurotrophins participate in the pathophysiology of mood disorders. We have developed transgenic mice overexpressing the full-length neurotrophin-3 receptor TrkC (TgNTRK3) in the central nervous system. [...]
2006 - 10.1016/j.nbd.2006.07.015
Neurobiology of disease, Vol. 24, Num. 2 (2006) , p. 403-18  

Articles : 11 registres trobats   1 - 10següent  anar al registre:
Documents de recerca 1 registres trobats  
1.
53 p, 590.6 KB Study of synaptic proteins and neuronal cell death mechanisms in animal degenerative disorders / Sisó Llonch, Sílvia ; Pumarola i Batlle, Martí, dir. (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ; Ferrer, Isidro, dir. (Universitat de Barcelona)
La neuropatologia degenerativa inclou un grup de malalties que cursen amb la degeneració progresiva del teixit nerviós tant en animals com en persones, i causant una pèrdua neuronal i una reacció glial, majoritàriament astrocítica en el Sistema Nerviós Central. [...]
Degenerative neuropathology brings together all animal and human disorders in which the nervous tissue has features of neurodegneration such as neuronal loss and gliosis, preferently astrocytosis. The distribution of the lesions is usually focal or multifocal. [...]

Bellaterra : Universitat Autònoma de Barcelona, 2002
2 documents

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