Results overview: Found 4 records in 0.03 seconds.
Articles, 4 records found
Articles 4 records found  
1.
2 p, 188.6 KB Synthesis, in vitro profiling, and in vivo efficacy studies of a new family of multitarget antiAlzheimer compounds / Pérez-Areales, Francisco Javier (Universitat de Barcelona) ; Garrido, María (Instituto de Química Avanzada de) ; Catalunya (IQAC-CSIC) ; Aso, Ester (Universitat de Barcelona) ; Bartolini, Manuela (Department of Pharmacy and Biotechnology. Alma Mater Studiorum University of Bologna) ; De Simone, Angela (University of Bologna. Department for Life Quality Studies) ; Espargaró Colomé, Alba (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Ginex, Tiziana (Universitat de Barcelona) ; Sabate, Raimon (Universitat de Barcelona) ; Pérez, Belén (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ; Andrisano, Vincenza (University of Bologna. Department for Life Quality Studies) ; Luque, Francisco Javier (Universitat de Barcelona) ; Ferrer, Isidro (Universitat de Barcelona. Unitat de Neuropatologia Experimental) ; Ciruela, Francisco (Universitat de Barcelona) ; Messeguer, Àngel (Instituto de Química Avanzada de) ; Catalunya (IQAC-CSIC) ; Muñoz-Torrero López-Ibarra, Diego (Universitat de Barcelona. Laboratori de Química Farmacèutica)
Simultaneous modulation of several targets or athological events with a key pathogenic role is a promising strategy to tackle thus far difficult-to-cure or incurable multifactorial diseases, such as Alzheimer's disease (AD). [...]
2019 - 10.3390/proceedings2019022071
Proceedings, Vol. 22 (2019) , p. 1-2  
2.
14 p, 17.9 MB Involvement of Cellular Prion Protein in α-Synuclein Transport in Neurons / Urrea, Laura (Universitat de Barcelona) ; Segura-Feliu, Miriam (Universitat de Barcelona) ; Masuda-Suzukake, Masami (Metropolitan Institute of Medical Science (Setagaya-ku, Tokyo)) ; Hervera Abad, Arnau (Universitat de Barcelona) ; Pedraz, Lucas (Institut de Bioenginyeria de Catalunya (IBEC)) ; García Aznar, José Manuel (Universidad de Zaragoza) ; Vila Bover, Miquel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Samitier, Josep (Universitat de Barcelona) ; Torrents, Eduard (Institut de Bioenginyeria de Catalunya (IBEC)) ; Ferrer, Isidro (Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED)) ; Gavín, Rosalina (Universitat de Barcelona) ; Hagesawa, Masato (Metropolitan Institute of Medical Science (Setagaya-ku, Tokyo)) ; del Río, José Antonio (Universitat de Barcelona) ; Universitat Autònoma de Barcelona
The cellular prion protein, encoded by the gene Prnp, has been reported to be a receptor of β-amyloid. Their interaction is mandatory for neurotoxic effects of βamyloid oligomers. In this study, we aimed to explore whether the cellular prion protein participates in the spreading of α-synuclein. [...]
2017 - 10.1007/s12035-017-0451-4
Molecular neurobiology, Vol. 55 (february 2017) , p. 1847-1860  
3.
9 p, 525.8 KB Reduced ubiquitin C-terminal hydrolase-1 expression levels in dementia with Lewy bodies / Barrachina, Marta (Hospital Universitari de Bellvitge) ; Castaño, Esther (Universitat de Barcelona. Unitat de Biologia) ; Dalfo Capella, Esther (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Maes, Tamara (Parc Científic de Barcelona. ORYZON Genomics) ; Buesa, Carlos (Universitat de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Ferrer, Isidro (Universitat de Barcelona. Unitat de Neuropatologia Experimental)
Parkinson disease (PD) and dementia with Lewy bodies (DLB) are characterized by the accumulation of abnormal α-synuclein and ubiquitin in protein aggregates conforming Lewy bodies and Lewy neurites. [...]
2006 - 10.1016/j.nbd.2005.11.005
Neurobiology of disease, Vol. 22, Num. 2 (2006) , p. 265-73  
4.
12 p, 2.7 MB Crtc1 activates a transcriptional program deregulated at early Alzheimer's disease-related stages / Parra Damas, Arnaldo J. (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Valero, Jorge (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Chen, Meng (Universitat Autònoma de Barcelona. Institut de Neurociències) ; España Agustí, Judit (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Martín, Elsa (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Ferrer, Isidro (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Rodríguez Álvarez, José (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Saura Antolín, Carlos A. (Carlos Alberto) (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Cognitive decline is associated with gene expression changes in the brain, but the transcriptional mechanisms underlying memory impairments in cognitive disorders, such as Alzheimer's disease (AD), are largely unknown. [...]
2014 - 10.1523/JNEUROSCI.5288-13.2014
The Journal of neuroscience, Vol. 34 No. 17 (April 2014) , p. 5776-5787  

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