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1.
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4 p, 256.4 KB |
Hemadsorption as a Treatment Option for Multisystem Inflammatory Syndrome in Children Associated With COVID-19. A Case Report
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Ruiz-Rodríguez, Juan Carlos (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Chiscano-Camón, Luis (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Palmada, Clara (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ruiz-Sanmartin, Adolf (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
García-de-Acilu, Marina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Plata-Menchaca, Erika (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Perurena-Prieto, Janire (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Hernandez-Gonzalez, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pérez-Carrasco, Marcos (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Soler-Palacín, Pere (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ferrer, Ricard (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Multisystem Inflammatory Syndrome in Children (MIS-C) associated with COVID-19 is characterized by hypercytokinemia leading to overwhelming inflammation. We describe the use of a hemadsorption device as part of the supportive treatment for cytokine storm.
2021 -  10.3389/fimmu.2021.665824
Frontiers in immunology, Vol. 12 (june 2021)
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2.
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9 p, 991.4 KB |
The protective association of endogenous immunoglobulins against sepsis mortality is restricted to patients with moderate organ failure
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Martin-Loeches, Ignacio (James's University Hospitals Dublin) ;
Muriel-Bombín, Arturo (Hospital Universitario Río Hortega (Valladolid)) ;
Ferrer, Ricard (Hospital Universitari Vall d'Hebron) ;
Artigas, Antonio (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Sole-Violan, Jordi (Hospital Universitario de Gran Canaria Dr. Negrín) ;
Lorente, Leonardo (Hospital Universitario de Canarias (La Laguna)) ;
Andaluz-Ojeda, David (Hospital Clínico Universitario (Valladolid)) ;
Prina-Mello, Adriele (James's St (Irlanda)) ;
Herrán-Monge, Ruben (Hospital Universitario Río Hortega (Valladolid)) ;
Suberviola, Borja (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ;
Rodriguez-Fernandez, Ana (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ;
Merino, Pedro (Hospital Universitario Río Hortega (Valladolid)) ;
Loza, Ana M. (Hospital Universitario Virgen de Valme (Sevilla, Andalusia)) ;
Garcia-Olivares, Pablo (Hospital General Universitario Gregorio Marañón) ;
Anton, Eduardo (Critical Care Medicine Service, Hospital de Manacor) ;
Tamayo, Eduardo (Hospital Clínico Universitario (Valladolid)) ;
Trapiello, Wysali (Hospital Clínico Universitario (Valladolid)) ;
Blanco, Jesús (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Bermejo-Martin, Jesús F. (Hospital Clínico Universitario (Valladolid)) ;
Universitat Autònoma de Barcelona
Pre-evaluation of endogenous immunoglobulin levels is a potential strategy to improve the results of intravenous immunoglobulins in sepsis, but more work has to be done to identify those patients who could benefit the most from this treatment. [...]
2017 - 10.1186/s13613-017-0268-3
Annals of Intensive Care, Vol. 7 (april 2017)
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3.
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10 p, 1.4 MB |
Epidemiology of sepsis in Catalonia : analysis of incidence and outcomes in a European setting
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Yébenes, Juan Carlos (Hospital de Mataró. Consorci Sanitari del Maresme) ;
Ruiz-Rodriguez, Juan Carlos (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ferrer, Ricard (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Clèries, Montserrat (Servei Català de la Salut) ;
Bosch, Anna (Servei Català de la Salut) ;
Lorencio, Carol (Hospital Universitari de Girona Doctor Josep Trueta) ;
Rodriguez, Alejandro (Hospital Universitari Joan XXIII de Tarragona) ;
Nuvials, Xavier (Institut de Recerca Biomèdica de Lleida) ;
Martin-Loeches, Ignacio (St James's University Hospital) ;
Artigas, Antoni (Universitat Autònoma de Barcelona) ;
Universitat Autònoma de Barcelona
Up-to-date identification of local trends in sepsis incidence and outcomes is of considerable public health importance. The aim of our study was to estimate annual incidence rates and in-hospital mortality trends for hospitalized patients with sepsis in a European setting, while avoiding selection bias in relation to different complexity hospitals. [...]
2017 - 10.1186/s13613-017-0241-1
Annals of Intensive Care, Vol. 7 (february 2017)
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4.
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18 p, 1.2 MB |
Feature selection for the accurate prediction of septic and cardiogenic shock ICU mortality in the acute phase
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Aushev, Alexander (Universitat Politècnica de Catalunya. Departament de Ciències de la Computació) ;
Ripoll, Vicent Ribas (Eurecat (Barcelona)) ;
Vellido, Alfredo (Universitat Politècnica de Catalunya. Departament de Ciències de la Computació) ;
Aletti, Federico (University of California San Diego) ;
Pinto, Bernardo Bollen (Hôpitaux Universitaires de Genève) ;
Herpain, Antoine (Université Libre de Bruxelles) ;
Post, Emiel Hendrik (Department of Intensive Care, Hôpital Erasme - Université Libre de Bruxelles, Brussels, Belgium) ;
Medina, Eduardo Romay (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Ferrer, Ricard (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Baselli, Giuseppe (Politecnico di Milano) ;
Bendjelid, Karim (Hôpitaux Universitaires de Genève) ;
Universitat Autònoma de Barcelona
Circulatory shock is a life-threatening disease that accounts for around one-third of all admissions to intensive care units (ICU). It requires immediate treatment, which is why the development of tools for planning therapeutic interventions is required to deal with shock in the critical care environment. [...]
2018 - 10.1371/journal.pone.0199089
PloS one, Vol. 13 (november 2018)
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5.
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7 p, 203.4 KB |
Cytokine Hemoadsorption as Rescue Therapy for Critically Ill Patients With SARS-CoV-2 Pneumonia With Severe Respiratory Failure and Hypercytokinemia
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Ruiz-Rodríguez, Juan Carlos (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Chiscano-Camón, Luis (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Ruiz-Sanmartin, Adolf (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Palmada, Clara (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Paola Plata-Menchaca, Erika (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Franco-Jarava, Clara (Hospital Universitari Vall d'Hebron) ;
Pérez-Carrasco, Marcos (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Hernández-González, Manuel (Hospital Universitari Vall d'Hebron) ;
Ferrer, Ricard (Universitat Autònoma de Barcelona. Departament de Medicina)
Introduction: A dysregulated inflammatory response, known as "cytokine storm", plays an important role in the pathophysiology of coronavirus 2019 disease (COVID-19). Identifying patients with a dysregulated inflammatory response and at high risk for severe respiratory failure, organ dysfunction, and death is clinically relevant, as they could benefit from the specific therapies, such as cytokine removal by hemoadsorption. [...]
2022 - 10.3389/fmed.2021.779038
Frontiers in Medicine, Vol. 8 (january 2022)
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6.
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10 p, 3.1 MB |
Label-Free Plasmonic Biosensor for Rapid, Quantitative, and Highly Sensitive COVID-19 Serology : Implementation and Clinical Validation
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Calvo Lozano, Olalla (Institut Català de Nanociència i Nanotecnologia) ;
Sierra, Miquel (Institut Català de Nanociència i Nanotecnologia) ;
Soler Aznar, María (Institut Català de Nanociència i Nanotecnologia) ;
Estévez, M. Carmen (Institut Català de Nanociència i Nanotecnologia) ;
Chiscano-Camón, Luis (Hospital Universitari Vall d'Hebron) ;
Ruiz-Sanmartin, Adolfo (Hospital Universitari Vall d'Hebron) ;
Ruiz-Rodriguez, Juan Carlos (Hospital Universitari Vall d'Hebron) ;
Ferrer, Ricard (Hospital Universitari Vall d'Hebron) ;
González-López, Juanjo (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Esperalba, Juliana (Hospital Universitari Vall d'Hebron) ;
Fernandez-Naval, Candela (Hospital Universitari Vall d'Hebron) ;
Bueno, Leticia (Hospital Clínic i Provincial de Barcelona) ;
López-Aladid, Ruben (Hospital Clínic i Provincial de Barcelona) ;
Torres, Antoni (Hospital Clínic i Provincial de Barcelona) ;
Fernández-Barat, Laia (Hospital Clínic i Provincial de Barcelona) ;
Attoumani, Sarah (Aix-Univ-IRD. Unité Des Virus Émergents) ;
Charrel, Rémi (Aix-Univ-IRD. Unité Des Virus Émergents) ;
Coutard, Bruno (Aix-Univ-IRD. Unité Des Virus Émergents) ;
Lechuga, Laura (Institut Català de Nanociència i Nanotecnologia)
Serological tests are essential for the control and management of COVID-19 pandemic (diagnostics and surveillance, and epidemiological and immunity studies). We introduce a direct serological biosensor assay employing proprietary technology based on plasmonics, which offers rapid (<15 min) identification and quantification of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies in clinical samples, without signal amplification. [...]
2022 - 10.1021/acs.analchem.1c03850
Analytical chemistry, Vol. 94, Issue 2 (January 2022) , p. 975-984
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7.
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8 p, 1.8 MB |
Symptoms of burnout in intensive care unit specialists facing the COVID-19 outbreak
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Azoulay, Elie (Hôpital Saint-Louis) ;
De Waele, Jan J (Universitair Ziekenhuis Gent) ;
Ferrer, Ricard (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Staudinger, T. (Medical University of Vienna) ;
Borkowska, M. (Universitair Ziekenhuis Gent) ;
Povoa, P. (Hospital de São Francisco Xavier (Lisboa, Portugal)) ;
Iliopoulou, K. (ICU Nurse Manager General Military Hospital) ;
Artigas, A. (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Schaller, S.J. (Technical University of Munich) ;
Hari, M.S. (St Thomas' Hospital) ;
Pellegrini, M. (University of Gothenburg) ;
Darmon, M. (Hôpital Saint-Louis) ;
Kesecioglu, J. (Utrecht University) ;
Cecconi, Maurizio (Humanitas University) ;
Universitat Autònoma de Barcelona
Background: The COVID-19 pandemic has resulted in an unprecedented healthcare crisis with a high prevalence of psychological distress in healthcare providers. We sought to document the prevalence of burnout syndrome amongst intensivists facing the COVID-19 outbreak. [...]
2020 - 10.1186/s13613-020-00722-3
Annals of Intensive Care, Vol. 10 Núm. 1 (january 2020) , p. 110
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8.
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9.
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13 p, 3.0 MB |
Naturally occurring SARS-CoV-2 gene deletions close to the spike S1/S2 cleavage site in the viral quasispecies of COVID19 patients
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Andrés, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Garcia-Cehic, D. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gregori i Font, Josep (Roche Diagnostics SL (Sant Cugat del Valles)) ;
Piñana, Maria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodriguez-Frias, Francisco (Universitat Autònoma de Barcelona) ;
Guerrero-Murillo, Mercedes (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Esperalba, Juliana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rando, Adriana (Hospital Universitari Vall d'Hebron) ;
Goterris, Lidia (Hospital Universitari Vall d'Hebron) ;
Codina, Gema (Hospital Universitari Vall d'Hebron) ;
Quer, Susanna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martín, Maria Carmen (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Campins Martí, Magda (Hospital Universitari Vall d'Hebron) ;
Ferrer, Ricard (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Almirante Gragera, Benito (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Esteban Mur, Juan Ignacio (Universitat Autònoma de Barcelona) ;
Pumarola, Tomás (Universitat Autònoma de Barcelona) ;
Antón, Andrés (Universitat Autònoma de Barcelona) ;
Quer, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca)
The SARS-CoV-2 spike (S) protein, the viral mediator for binding and entry into the host cell, has sparked great interest as a target for vaccine development and treatments with neutralizing antibodies. [...]
2020 - 10.1080/22221751.2020.1806735
Emerging microbes & infections, Vol. 9 Núm. 1 (september 2020) , p. 1900-1911
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10.
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7 p, 1.4 MB |
International variation in the management of severe COVID-19 patients
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Azoulay, Elie (Hôpital Saint-Louis) ;
De Waele, Jan J (Universitair Ziekenhuis Gent) ;
Ferrer, Ricard (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Staudinger, T. (Medical University of Vienna) ;
Borkowska, M. (Universitair Ziekenhuis Gent) ;
Povoa, P. (New University of Lisbon) ;
Iliopoulou, K. (ICU Nurse Manager General Military Hospital) ;
Artigas, A. (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Schaller, S.J. (Humboldt-Universität zu Berlin) ;
Shankar-Hari, M. (Guy's and St Thomas' NHS Foundation Trust) ;
Pellegrini, M. (University of Gothenburg) ;
Darmon, M. (Hôpital Saint-Louis. Paris University) ;
Kesecioglu, J. (Utrecht University) ;
Cecconi, Maurizio (Humanitas University) ;
Universitat Autònoma de Barcelona
Background: There is little evidence to support the management of severe COVID-19 patients. Methods: To document this variation in practices, we performed an online survey (April 30-May 25, 2020) on behalf of the European Society of Intensive Care Medicine (ESICM). [...]
2020 - 10.1186/s13054-020-03194-w
Critical Care, Vol. 24 Núm. 1 (may 2020) , p. s13054-020-03194-w
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