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11 p, 2.6 MB |
Biomarkers and clinical scores to aid the identification of disease severity and intensive care requirement following activation of an in-hospital sepsis code
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Baldirà, Jaume (Universitat Autònoma de Barcelona. Department de Medicina) ;
Ruiz-Rodríguez, Juan Carlos (Vall d'Hebron Institute of Research. Shock, Organ Dysfunction and Resuscitation Research Group) ;
Wilson, Darius Cameron (Vall d'Hebron Institute of Research. Shock, Organ Dysfunction and Resuscitation Research Group) ;
Ruiz-Sanmartin, Adolf (Vall d'Hebron Institute of Research. Shock, Organ Dysfunction and Resuscitation Research Group) ;
Cortes, Alejandro (Vall d'Hebron Institute of Research. Shock, Organ Dysfunction and Resuscitation Research Group) ;
Chiscano, Luis (Vall d'Hebron Institute of Research. Shock, Organ Dysfunction and Resuscitation Research Group) ;
Ferrer-Costa, Roser (Vall d'Hebron University Hospital. Biochemistry Department, Clinical Laboratories) ;
Comas, Inma (Vall d'Hebron University Hospital. Biochemistry Department, Clinical Laboratories) ;
Larrosa, Nieves (Universitat Autònoma de Barcelona. Department de Genètica i Microbiologia) ;
Fàbrega, Anna (Vall d'Hebron University Hospital. Microbiology Department) ;
González, Juan José (Universitat Autònoma de Barcelona. Department de Genètica i Microbiologia) ;
Ferrer, Ricard (Vall d'Hebron Institute of Research. Shock, Organ Dysfunction and Resuscitation Research Group)
Few validated biomarker or clinical score combinations exist which can discriminate between cases of infection and other non-infectious conditions following activation of an in-hospital sepsis code, as well as provide an accurate severity assessment of the corresponding host response. [...]
2020 -  10.1186/s13613-020-0625-5
Annals of Intensive Care, Vol. 10 (January 2020) , art. 7
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24 p, 1.4 MB |
Label-free Bacteria Quantification in Blood Plasma by a Bioprinted Microarray Based Interferometric Point-of-Care Device
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Dey, Priyanka (Institut Català de Nanociència i Nanotecnologia) ;
Fabri Faja, Nuria (Institut Català de Nanociència i Nanotecnologia) ;
Calvo Lozano, Olalla (Institut Català de Nanociència i Nanotecnologia) ;
Terborg, Roland A. (ICFO-Institut de Ciències Fotòniques) ;
Belushkin, Alexander (École Polytechnique Fédérale de Lausanne) ;
Yesilköy, Filiz (École Polytechnique Fédérale de Lausanne) ;
Fàbrega, Anna (Universitat Autònoma de Barcelona. Departament de Microbiologia Clínica) ;
Ruiz Rodríguez, Juan Carlos (Hospital Universitari Vall d'Hebron) ;
Ferrer Roca, Ricard (Hospital Universitari Vall d'Hebron) ;
González López, Juan José (Hospital Universitari Vall d'Hebron) ;
Estévez Alberola, Maria Carmen (Institut Català de Nanociència i Nanotecnologia) ;
Altug, Hatice (École Polytechnique Fédérale de Lausanne) ;
Pruneri, Valerio (Institució Catalana de Recerca i Estudis Avançats) ;
Lechuga, Laura M. (Institut Català de Nanociència i Nanotecnologia)
Existing clinical methods for bacteria detection lack speed, sensitivity, and, importantly, point-of-care (PoC) applicability. Thus, finding ways to push the sensitivity of clinical PoC biosensing technologies is crucial. [...]
2019 - 10.1021/acssensors.8b00789
ACS Sensors, Vol. 4, Issue 1 (January 2019) , p. 52-60
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11 p, 838.8 KB |
Efficacy and safety of trimodulin, a novel polyclonal antibody preparation, in patients with severe community-acquired pneumonia : a randomized, placebo-controlled, double-blind, multicenter, phase II trial (CIGMA study)
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Welte, Tobias (Carl-Neuberg-Str. 1, 30625 Hannover, Germany) ;
Dellinger, R. Phillip (Camden, NJ USA) ;
Ebelt, Henning (Halle (Saale), Germany) ;
Ferrer, Miguel (Barcelona, Spain) ;
Opal, Steven M. (Providence, RI USA) ;
Singer, Mervyn (London, UK) ;
Vincent, Jean-Louis (Brussels, Belgium) ;
Werdan, Karl (Halle (Saale), Germany) ;
Martin-Loeches, Ignacio (Sabadell, Spain) ;
Almirall, Jordi (Hospital de Mataró) ;
Artigas, Antonio (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Ignacio Ayestarán, Jose (Palma de Mallorca, Spain) ;
Nuding, Sebastian (Halle (Saale), Germany) ;
Ferrer, Ricard (Hospital Universitario Mútua de Terrassa, SODIR-VHIR Research Group, Barcelona, Spain) ;
Sirgo Rodríguez, Gonzalo (Tarragona, Spain) ;
Shankar-Hari, Manu (London, UK) ;
Álvarez-Lerma, Francisco (Hospital del Mar (Barcelona)) ;
Riessen, Reimer (Tübingen, Germany) ;
Sirvent, Josep-Maria (Servicio de Medicina Intensiva, Hospital U. Girona Dr. Josep Trueta, Avinguda França, Girona, Spain) ;
Kluge, Stefan (Hamburg, Germany) ;
Zacharowski, Kai (Frankfurt, Germany) ;
Bonastre Mora, Juan (Valencia, Spain) ;
Lapp, Harald (Medizinische Klinik, Kardiologie und Intensivmedizin, Helios Klinikum Erfurt, Erfurt, Germany) ;
Wöbker, Gabriele (Klinik für Intensivmedizin, Helios Universitätsklinikum Wuppertal, Wuppertal, Germany) ;
Achtzehn, Ute (Chemnitz, Germany) ;
Brealey, David (Critical Care Unit, NIHR University College London Hospitals Biomedical Research Centre, University College London Hospitals, NHS Foundation Trust, London, UK) ;
Kempa, Axel (Stuttgart, Germany) ;
Sánchez García, Miguel (Madrid, Spain) ;
Brederlau, Jörg (Helios Klinikum Berlin-Buch, Klinik für Intensivmedizin, Berlin, Germany) ;
Kochanek, Matthias (Cologne, Germany) ;
Reschreiter, Henrik Peer (Poole, Dorset UK) ;
Wise, Matthew P. (Heath Park, Cardiff, UK) ;
Belohradsky, Bernd H. (Munich, Germany) ;
Bobenhausen, Iris (Dreieich, Germany) ;
Dälken, Benjamin (Dreieich, Germany) ;
Dubovy, Patrick (Dreieich, Germany) ;
Langohr, Patrick (Dreieich, Germany) ;
Mayer, Monika (Dreieich, Germany) ;
Schüttrumpf, Jörg (Dreieich, Germany) ;
Wartenberg-Demand, Andrea (Dreieich, Germany) ;
Wippermann, Ulrike (Dreieich, Germany) ;
Wolf, Daniele (Dreieich, Germany) ;
Torres, Antoni (Barcelona, Spain)
The CIGMA study investigated a novel human polyclonal antibody preparation (trimodulin) containing ~ 23% immunoglobulin (Ig) M, ~ 21% IgA, and ~ 56% IgG as add-on therapy for patients with severe community-acquired pneumonia (sCAP). [...]
2018 - 10.1007/s00134-018-5143-7
Intensive Care Medicine, Vol. 44 (april 2018) , p. 438-448
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9 p, 598.1 KB |
Near-infrared spectroscopy StO monitoring to assess the therapeutic effect of drotrecogin alfa (activated) on microcirculation in patients with severe sepsis or septic shock
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Masip, Jordi (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Mesquida, Jaume (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Luengo, Cecilia (Department of Anesthesiology & Critical Care Medicine, SAMU and Laboratory of Anesthesiology, Hospital Lariboisière, Paris, 2, rue Ambroise - Paré, 75010 Paris, 10ème, France) ;
Gili, Gisela (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Gomà, Gemma (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Ferrer, Ricard (Intensive Care Department, Mutua Terrassa University Hospital, University of Barcelona. CIBER Enfermedades Respiratorias, Plaça Doctor Robert, Terrassa (Barcelona) CP: 08221, Spain) ;
Teboul, Jean Louis (Service de Réanimation Médicale, Centre Hospitalo-Universitaire de Bicêtre, 78 rue du Général-Leclerc, Le Kremlin-Bicêtre 94 270, France) ;
Payen, Didier (Department of Anesthesiology & Critical Care Medicine, SAMU and Laboratory of Anesthesiology, Hospital Lariboisière, Paris, 2, rue Ambroise - Paré, 75010 Paris, 10ème, France) ;
Artigas, Antonio (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Universitat Autònoma de Barcelona
Sepsis is a leading cause of death despite appropriate management. There is increasing evidence that microcirculatory alterations might persist independently from macrohemodynamic improvement and are related to clinical evolution. [...]
2013 - 10.1186/2110-5820-3-30
Annals of Intensive Care, Vol. 3 (september 2013) , p. 30
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