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16 p, 1020.6 KB Transgenic mice overexpressing the full-length neurotrophin receptor TrkC exhibit increased catecholaminergic neuron density in specific brain areas and increased anxiety-like behavior and panic reaction. / Dierssen, Mara (Biomedical Research Park. Genes and Disease Program, Genomic Regulation Center) ; Gratacòs, Mònica (Biomedical Research Park. Genes and Disease Program, Genomic Regulation Center) ; Sahún, Ignasi (Biomedical Research Park. Genes and Disease Program, Genomic Regulation Center) ; Martín, Miguel (Universitat Pompeu Fabra. Àrea de Neurofarmacologia) ; Gallego, Xavier (Biomedical Research Park. Genes and Disease Program, Genomic Regulation Center) ; Amador-Arjona, Alehandro (Biomedical Research Park. Genes and Disease Program, Genomic Regulation Center) ; Martínez de Lagrán María (Biomedical Research Park. Genes and Disease Program, Genomic Regulation Center) ; Murtra, Patricia (Universitat Pompeu Fabra. Àrea de Neurofarmacologia) ; Martí, Eulalia (Biomedical Research Park. Genes and Disease Program, Genomic Regulation Center) ; Pujana, Miguel A. (Biomedical Research Park. Genes and Disease Program, Genomic Regulation Center) ; Ferrer, Isidre (Hospital Prínceps d'Espanya. Àrea de neuropatologia) ; Dalfo Capella, Esther (Universitat Autònoma de Barcelona. Departament de Biologia i Bioquímica Molecular) ; Martínez-Cué, Carmen (Universidad de Cantabria. Departamento de Psicologia y Farmacologia) ; Flórez, Jesús (Universidad de Cantabria. Departamento de Psicologia y Farmacologia) ; Torres-Peraza, Jesús F. (Universitat de Barcelona. Departament de Biologia Cel·lular i Anatomia Patològica) ; Alberch i Vié, Jordi (Universitat de Barcelona. Departament de Biologia Cel·lular i Anatomia Patològica) ; Maldonado, Rafael (Universitat Pompeu Fabra. Àrea de Neurofarmacologia) ; Fillat, Cristina (Biomedical Research Park. Genes and Disease Program, Genomic Regulation Center) ; Estivill, Xavier (Biomedical Research Park. Genes and Disease Program, Genomic Regulation Center)
Accumulating evidence has suggested that neurotrophins participate in the pathophysiology of mood disorders. We have developed transgenic mice overexpressing the full-length neurotrophin-3 receptor TrkC (TgNTRK3) in the central nervous system. [...]
2006 - 10.1016/j.nbd.2006.07.015
Neurobiology of disease, Vol. 24, Num. 2 (2006) , p. 403-18  

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