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Resultados globales: 8 registros encontrados en 0.02 segundos.
Artículos, Encontrados 8 registros
Artículos Encontrados 8 registros  
1.
14 p, 1002.6 KB Circulating MicroRNAs as a Tool for Diagnosis of Liver Disease Progression in People Living with HIV-1 / Martinez, Miguel Angel (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Tural, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Franco Cirera, Sandra (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Universitat Autònoma de Barcelona
MicroRNAs (miRNAs) are small, non-coding RNAs that post-transcriptionally regulate gene expression by binding specific cell mRNA targets, preventing their translation. miRNAs are implicated in the regulation of important physiological and pathological pathways. [...]
2022 - 10.3390/v14061118
Viruses, Vol. 14 (may 2022)  
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2.
10 p, 1.3 MB Normalization of circulating plasma levels of miRNAs in HIV-1/HCV co-infected patients following direct-acting antiviral-induced sustained virologic response / Franco Cirera, Sandra (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Llibre, Josep M.. (Institut Germans Trias i Pujol) ; Jou, Toni (Fundació LLuita Contra les Infeccions) ; Tural, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Martínez, Miguel Angel (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Universitat Autònoma de Barcelona
In a previous recent work, we recognized three plasma circulating microRNAs (miRNAs)-miR-100-5p_iso3p:-2, miR-122-5p, and miR-192-5p-that correlate largely with liver fibrosis evolution in human immunodeficiency virus type 1 (HIV-1)/hepatitis C virus (HCV) co-infected patients. [...]
2023 - 10.1016/j.heliyon.2022.e12686
Heliyon, Vol. 9 (january 2023)  
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3.
8 p, 1.6 MB Rapid and accurate quantification of isomiRs by RT-qPCR / Franco Cirera, Sandra (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Pluvinet, Raquel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Sanchez-Herrero, Jose Francisco (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Sumoy, Lauro (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Martinez, Miguel Angel (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
Currently, microRNAs (miRs) are annotated as a single defined sequence (canonical), even though high-throughput small RNA sequencing has identified miR isoforms (isomiRs) that differ from their canonical counterparts in length, sequence, or both. [...]
2022 - 10.1038/s41598-022-22298-7
Scientific reports, Vol. 12 (october 2022)  
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4.
10 p, 949.6 KB Synonymous Codon Pair Recoding of the HIV-1 env Gene Affects Virus Replication Capacity / Jordan de Paiz, Ana (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Franco Cirera, Sandra (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Martinez, Miguel Angel (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
Synonymous codon pair deoptimization is an efficient strategy for virus attenuation; however, the underlying mechanism remains controversial. Here, we optimized and deoptimized the codon pair bias (CPB) of the human immunodeficiency virus type 1 (HIV-1) envelope (env) gene to investigate the influence of env synonymous CPB recoding on virus replication capacity, as well as the potential mechanism. [...]
2021 - 10.3390/cells10071636
Cells, Vol. 10 (june 2021)  
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5.
7 p, 533.9 KB Canine Hepacivirus NS3 Serine Protease Can Cleave the Human Adaptor Proteins MAVS and TRIF / Parera, Mariona (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Martrus, Gloria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Franco Cirera, Sandra (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Martinez, Miguel Angel (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Universitat Autònoma de Barcelona
Canine hepacivirus (CHV) was recently identified in domestic dogs and horses. The finding that CHV is genetically the virus most closely related to hepatitis C virus (HCV) has raised the question of whether HCV might have evolved as the result of close contact between dogs and/or horses and humans. [...]
2012 - 10.1371/journal.pone.0042481
PloS one, Vol. 7 (august 2012)  
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6.
13 p, 437.7 KB Impact of in Liver Disease Progression / Martinez, Miguel Angel (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Franco Cirera, Sandra (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Universitat Autònoma de Barcelona
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a novel coronavirus that causes coronavirus disease 19 (COVID-19), which has infected millions of people worldwide in only a few months. [...]
2021 - 10.1002/hep4.1745
Hepatology Communications, Vol. 5 No. 7 (may 2021) , p. 1138-1150  
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7.
14 p, 1.1 MB Synonymous genome recoding : a tool to explore microbial biology and new therapeutic strategies / Martínez, Miguel Angel (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Jordan de Paiz, Ana (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Franco Cirera, Sandra (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Nevot Banús, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Universitat Autònoma de Barcelona
Synthetic genome recoding is a new means of generating designed organisms with altered phenotypes. Synonymous mutations introduced into the protein coding region tolerate modifications in DNA or mRNA without modifying the encoded proteins. [...]
2019 - 10.1093/nar/gkz831
Nucleic acids research, Vol. 47 (october 2019) , p. 10506-10519  
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8.
15 p, 1.1 MB Pemetrexed/Carboplatin/Bevacizumab followed by maintenance Pemetrexed/Bevacizumab in hispanic patients with non-squamous non-small cell lung cancer: outcomes according to Thymidylate Synthase Expression / Cardona Zorrilla, Andrés Felipe (Clínica del Country (Bogotà, Colòmbia)) ; Rojas, Leonardo (Fundación de Investigación Clínica y Molecular en Cáncer (Bogotà, Colòmbia)) ; Wills, Beatriz (Clínica del Country (Bogotà, Colòmbia)) ; Arrieta, Oscar (Instituto Nacional de Cancerología (Ciutat de Mèxic)) ; Carranza, Hernán (Clínica del Country (Bogotà, Colòmbia)) ; Vargas, Carlos (Clínica del Country (Bogotà, Colòmbia)) ; Otero, Jorge (Clínica del Country (Bogotà, Colòmbia)) ; Cuello, Mauricio (Universidad de la República (Montevideo, Uruguai)) ; Corrales, Luis (Hospital San Juan de Dios (San José, Costa Rica)) ; Martín, Claudio (Instituto Alexander Fleming (Buenos Aires, Argentina)) ; Ortiz, Carlos (Clínica del Country (Bogotà, Colòmbia)) ; Franco Cirera, Sandra (Clínica del Country (Bogotà, Colòmbia)) ; Rosell, Rafael (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Objective: To evaluate the efficacy and safety of pemetrexed, carboplatin and bevacizumab (PCB) followed by maintenance therapy with pemetrexed and bevacizumab (PB) in chemotherapy-naïve patients with stage IV non-squamous non-small cell lung cancer (NSCLC) through the influence of thymidylate synthase (TS) protein and mRNA expression on several outcomes. [...]
2016 - 10.1371/journal.pone.0154293
PloS one, Vol. 11 Núm. 5 (May 2016)  
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