Results overview: Found 5 records in 0.02 seconds.
Articles, 5 records found
Articles 5 records found  
1.
15 p, 5.1 MB Slow progression of pediatric HIV associates with early CD8 + T cell PD-1 expression and a stem-like phenotype / Vieira, Vinicius (Department of Paediatrics, University of Oxford) ; Lim, Nicholas (Department of Paediatrics, University of Oxford) ; Singh, Alveera (Africa Health Research Institute) ; Leitman, Ellen (Department of Paediatrics, University of Oxford) ; Dsouza, Reena (Department of Paediatrics, University of Oxford) ; Adland, Emily (Department of Paediatrics, University of Oxford) ; Muenchhoff, Maximilian (German Center for Infection Research) ; Roider, Julia (Department of Infectious Diseases, Ludwig-Maximilians-University) ; Marin Lopez, Miguel (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Carabelli, Julieta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Giandhari, Jennifer (KwaZulu-Natal Research Innovation and Sequencing Platform, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal) ; Groll, Andreas (Department of Statistics, TU Dortmund University) ; Jooste, Pieter (Department of Paediatrics, Kimberley Hospital) ; Prado, Julia G. (Institut Germans Trias i Pujol) ; Thobakgale, Christina (University of KwaZulu-Natal) ; Dong, Krista (Ragon Institute of MGH, MIT and Harvard (Estats Units d'Amèrica)) ; Kiepiela, Photini (Wits Health Consortium, Johannesburg) ; Prendergast, Andrew J. (Zvitambo Institute for Maternal and Child Health Research) ; Tudor-Williams, Gareth (Imperial College London. Centre for Paediatrics and Child Health) ; Frater, John (Oxford NIHR Biomedical Research Centre) ; Walker, Bruce D. (Ragon Institute of MGH, MIT and Harvard) ; Ndung'u, Thumbi (University College London. Division of Infection and Immunity) ; Ramsuran, Veron (Centre for the AIDS Programme of Research in South Africa) ; Leslie, Alasdair (School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal) ; Kløverpris, Henrik N. (Department of Immunology and Microbiology, University of Copenhagen) ; Goulder, Philip (Doris Duke Medical Research Institute, University of KwaZulu-Natal) ; Universitat Autònoma de Barcelona
HIV nonprogression despite persistent viremia is rare among adults who are naive to antiretroviral therapy (ART) but relatively common among ART-naive children. Previous studies indicate that ART-naive pediatric slow progressors (PSPs) adopt immune evasion strategies similar to those described in natural hosts of SIV. [...]
202 - 10.1172/jci.insight.156049
JCI Insight, Vol. 8 (february 2023)  
2.
186.3 KB Editorial : Immune Surveillance of the HIV Reservoir: Mechanisms, Therapeutic Targeting and New Avenues for HIV Cure / Prado, Julia G. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Frater, John (University of Oxford)
2020 - 10.3389/fimmu.2020.00070
Frontiers in immunology, Vol. 11 (january 2020)  
3.
8 p, 759.1 KB Evidence for HIV-1 cure after CCR5 Δ32/Δ32 allogeneic haemopoietic stem-cell transplantation 30 months post analytical treatment interruption : a case report / Gupta, Ravindra Kumar (Africa Health Research Institute) ; Peppa, Dimitra (UCL Great Ormond Street Institute of Child Health) ; Hill, Alison L. (Harvard University. Department for Organismic and Evolutionary Biology) ; Gálvez, Cristina (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Salgado, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Pace, Matthew (Nuffield Department of Medicine, University of Oxford) ; McCoy, Laura E. (Division of Infection and Immunity, University College London (UCL)) ; Griffith, Sarah A. (Division of Infection and Immunity, University College London (UCL)) ; Thornhill, John (Imperial College London) ; Alrubayyi, Aljawharah (Nuffield Department of Medicine, University of Oxford) ; Huyveneers, Laura E. P. (Department of Medical Microbiology, University Medical Center) ; Nastouli, Eleni (UCL Great Ormond Street Institute of Child Health) ; Grant, Paul (Department of Virology, UCL Hospitals) ; Edwards, Simon G.. (Mortimer Market Centre, Department of HIV, Central and North West London NHS Trust) ; Innes, Andrew J. (Hammersmith Hospital (Londres)) ; Frater, John (Oxford National Institute for Health Research Biomedical Research Centre) ; Nijhuis, Monique (Department of Medical Microbiology, University Medical Center) ; Wensing, Anne Marie J. (Department of Medical Microbiology, University Medical Center) ; Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Olavarria, Eduardo (Mortimer Market Centre, Department of HIV, Central and North West London NHS Trust) ; Universitat Autònoma de Barcelona
The London patient (participant 36 in the IciStem cohort) underwent allogeneic stem-cell transplantation with cells that did not express CCR5 (CCR5 Δ32/Δ32); remission was reported at 18 months after analytical treatment interruption (ATI). [...]
2020 - 10.1016/S2352-3018(20)30069-2
The lancet. HIV, Vol. 7 (march 2020) , p. e340-e347  
4.
14 p, 2.0 MB Differential Immunodominance Hierarchy of CD8 + T-Cell Responses in HLA-B*27:05- and -B*27:02-Mediated Control of HIV-1 Infection / Adland, Emily ; Hill, Matilda ; Lavandier, Nora ; Csala, Anna ; Edwards, Anne ; Chen, Fabian ; Radkowski, Marek ; Kowalska, Justyna D. ; Paraskevis, Dimitrios ; Hatzakis, Angelos ; Valenzuela-Ponce, Humberto ; Pfafferott, Katja ; Williams, Ian ; Pellegrino, Pierre ; Borrow, Persephone ; Mori, Masahiko ; Rockstroh, Jürgen ; Prado, Julia G.. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Dalmau, Judith (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Martinez-Picado, Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Tudor-Williams, Gareth ; Frater, John ; Stryhn, Anette ; Buus, Soren ; Teran, Gustavo Reyes ; Mallal, Simon ; John, Mina ; Buchbinder, Susan ; Kirk, Gregory ; Martin, Jeffrey ; Michael, Nelson ; Fellay, Jacques ; Deeks, Steve ; Walker, Bruce D ; Avila-Rios, Santiago ; Cole, David ; Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Carrington, Mary ; Goulder, Philip ; Universitat Autònoma de Barcelona
The well-characterized association between HLA-B*27:05 and protection against HIV disease progression has been linked to immunodominant HLA-B*27:05-restricted CD8 + T-cell responses toward the conserved Gag KK10 (residues 263 to 272) and polymerase (Pol) KY9 (residues 901 to 909) epitopes. [...]
2018 - 10.1128/JVI.01685-17
Journal of Virology, Vol. 92 (january 2018)  
5.
26 p, 2.7 MB Discordant Impact of HLA on Viral Replicative Capacity and Disease Progression in Pediatric and Adult HIV Infection / Adland, Emily (University of Oxford) ; Paioni, Paolo (University of Oxford) ; Thobakgale, Christina (University of KwaZulu-Natal (Durban, Sud-àfrica)) ; Laker, Leana (Kimberley Hospital (Northern Cape, Sud-àfrica)) ; Mori, Luisa (Kimberley Hospital (Northern Cape, Sud-àfrica)) ; Muenchhoff, Maximilian (University of Oxford) ; Csala, Anna (University of Oxford) ; Clapson, Margaret (Saint Hospital for Children (London, Gran Bretanya)) ; Flynn, Jacquie (Saint Hospital for Children (London, Gran Bretanya)) ; Novelli, Vas (Saint Hospital for Children (London, Gran Bretanya)) ; Hurst, Jacob (University of Oxford) ; Naidoo, Vanessa (University of KwaZulu-Natal (Durban, Sud-àfrica)) ; Shapiro, Roger (Botswana Harvard AIDS Institute Partnership (Gaborone, Botswana)) ; Gary, Kuan-Hsiang Huang (University of Oxford) ; Frater, John (University of Oxford) ; Prendergast, Andrew (Queen Mary University of London) ; Prado, Julia G.. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Ndung'u, Thumbi (University of KwaZulu-Natal (Durban, Sud-àfrica)) ; Walker, Bruce D. (University of Oxford) ; Carrington, Mary (National Cancer Institute (Maryland, Estats Units d'Amèrica)) ; Jooste, Pieter (Kimberley Hospital (Northern Cape, Sud-àfrica)) ; Goulder, Philip J. R. (University of Oxford)
Abstract. HLA class I polymorphism has a major influence on adult HIV disease progression. An important mechanism mediating this effect is the impact on viral replicative capacity (VRC) of the escape mutations selected in response to HLA-restricted CD8+ T-cell responses. [...]
2015 - 10.1371/journal.ppat.1004954
PLOS pathogens, Vol. 11 Núm. 6 (June 2015)  

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6 Frater, John
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