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15 p, 5.1 MB |
Slow progression of pediatric HIV associates with early CD8 + T cell PD-1 expression and a stem-like phenotype
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Vieira, Vinicius (Department of Paediatrics, University of Oxford) ;
Lim, Nicholas (Department of Paediatrics, University of Oxford) ;
Singh, Alveera (Africa Health Research Institute) ;
Leitman, Ellen (Department of Paediatrics, University of Oxford) ;
Dsouza, Reena (Department of Paediatrics, University of Oxford) ;
Adland, Emily (Department of Paediatrics, University of Oxford) ;
Muenchhoff, Maximilian (German Center for Infection Research) ;
Roider, Julia (Department of Infectious Diseases, Ludwig-Maximilians-University) ;
Marin Lopez, Miguel (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Carabelli, Julieta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Giandhari, Jennifer (KwaZulu-Natal Research Innovation and Sequencing Platform, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal) ;
Groll, Andreas (Department of Statistics, TU Dortmund University) ;
Jooste, Pieter (Department of Paediatrics, Kimberley Hospital) ;
Prado, Julia G. (Institut Germans Trias i Pujol) ;
Thobakgale, Christina (University of KwaZulu-Natal) ;
Dong, Krista (Ragon Institute of MGH, MIT and Harvard (Estats Units d'Amèrica)) ;
Kiepiela, Photini (Wits Health Consortium, Johannesburg) ;
Prendergast, Andrew J. (Zvitambo Institute for Maternal and Child Health Research) ;
Tudor-Williams, Gareth (Imperial College London. Centre for Paediatrics and Child Health) ;
Frater, John (Oxford NIHR Biomedical Research Centre) ;
Walker, Bruce D. (Ragon Institute of MGH, MIT and Harvard) ;
Ndung'u, Thumbi (University College London. Division of Infection and Immunity) ;
Ramsuran, Veron (Centre for the AIDS Programme of Research in South Africa) ;
Leslie, Alasdair (School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal) ;
Kløverpris, Henrik N. (Department of Immunology and Microbiology, University of Copenhagen) ;
Goulder, Philip (Doris Duke Medical Research Institute, University of KwaZulu-Natal) ;
Universitat Autònoma de Barcelona
HIV nonprogression despite persistent viremia is rare among adults who are naive to antiretroviral therapy (ART) but relatively common among ART-naive children. Previous studies indicate that ART-naive pediatric slow progressors (PSPs) adopt immune evasion strategies similar to those described in natural hosts of SIV. [...]
202 - 10.1172/jci.insight.156049
JCI Insight, Vol. 8 (february 2023)
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8 p, 759.1 KB |
Evidence for HIV-1 cure after CCR5 Δ32/Δ32 allogeneic haemopoietic stem-cell transplantation 30 months post analytical treatment interruption : a case report
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Gupta, Ravindra Kumar (Africa Health Research Institute) ;
Peppa, Dimitra (UCL Great Ormond Street Institute of Child Health) ;
Hill, Alison L. (Harvard University. Department for Organismic and Evolutionary Biology) ;
Gálvez, Cristina (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Salgado, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Pace, Matthew (Nuffield Department of Medicine, University of Oxford) ;
McCoy, Laura E. (Division of Infection and Immunity, University College London (UCL)) ;
Griffith, Sarah A. (Division of Infection and Immunity, University College London (UCL)) ;
Thornhill, John (Imperial College London) ;
Alrubayyi, Aljawharah (Nuffield Department of Medicine, University of Oxford) ;
Huyveneers, Laura E. P. (Department of Medical Microbiology, University Medical Center) ;
Nastouli, Eleni (UCL Great Ormond Street Institute of Child Health) ;
Grant, Paul (Department of Virology, UCL Hospitals) ;
Edwards, Simon G.. (Mortimer Market Centre, Department of HIV, Central and North West London NHS Trust) ;
Innes, Andrew J. (Hammersmith Hospital (Londres)) ;
Frater, John (Oxford National Institute for Health Research Biomedical Research Centre) ;
Nijhuis, Monique (Department of Medical Microbiology, University Medical Center) ;
Wensing, Anne Marie J. (Department of Medical Microbiology, University Medical Center) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Olavarria, Eduardo (Mortimer Market Centre, Department of HIV, Central and North West London NHS Trust) ;
Universitat Autònoma de Barcelona
The London patient (participant 36 in the IciStem cohort) underwent allogeneic stem-cell transplantation with cells that did not express CCR5 (CCR5 Δ32/Δ32); remission was reported at 18 months after analytical treatment interruption (ATI). [...]
2020 - 10.1016/S2352-3018(20)30069-2
The lancet. HIV, Vol. 7 (march 2020) , p. e340-e347
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14 p, 2.0 MB |
Differential Immunodominance Hierarchy of CD8 + T-Cell Responses in HLA-B*27:05- and -B*27:02-Mediated Control of HIV-1 Infection
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Adland, Emily ;
Hill, Matilda ;
Lavandier, Nora ;
Csala, Anna ;
Edwards, Anne ;
Chen, Fabian ;
Radkowski, Marek ;
Kowalska, Justyna D. ;
Paraskevis, Dimitrios ;
Hatzakis, Angelos ;
Valenzuela-Ponce, Humberto ;
Pfafferott, Katja ;
Williams, Ian ;
Pellegrino, Pierre ;
Borrow, Persephone ;
Mori, Masahiko ;
Rockstroh, Jürgen ;
Prado, Julia G.. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Dalmau, Judith (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martinez-Picado, Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Tudor-Williams, Gareth ;
Frater, John ;
Stryhn, Anette ;
Buus, Soren ;
Teran, Gustavo Reyes ;
Mallal, Simon ;
John, Mina ;
Buchbinder, Susan ;
Kirk, Gregory ;
Martin, Jeffrey ;
Michael, Nelson ;
Fellay, Jacques ;
Deeks, Steve ;
Walker, Bruce D ;
Avila-Rios, Santiago ;
Cole, David ;
Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Carrington, Mary ;
Goulder, Philip ;
Universitat Autònoma de Barcelona
The well-characterized association between HLA-B*27:05 and protection against HIV disease progression has been linked to immunodominant HLA-B*27:05-restricted CD8 + T-cell responses toward the conserved Gag KK10 (residues 263 to 272) and polymerase (Pol) KY9 (residues 901 to 909) epitopes. [...]
2018 - 10.1128/JVI.01685-17
Journal of Virology, Vol. 92 (january 2018)
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26 p, 2.7 MB |
Discordant Impact of HLA on Viral Replicative Capacity and Disease Progression in Pediatric and Adult HIV Infection
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Adland, Emily (University of Oxford) ;
Paioni, Paolo (University of Oxford) ;
Thobakgale, Christina (University of KwaZulu-Natal (Durban, Sud-àfrica)) ;
Laker, Leana (Kimberley Hospital (Northern Cape, Sud-àfrica)) ;
Mori, Luisa (Kimberley Hospital (Northern Cape, Sud-àfrica)) ;
Muenchhoff, Maximilian (University of Oxford) ;
Csala, Anna (University of Oxford) ;
Clapson, Margaret (Saint Hospital for Children (London, Gran Bretanya)) ;
Flynn, Jacquie (Saint Hospital for Children (London, Gran Bretanya)) ;
Novelli, Vas (Saint Hospital for Children (London, Gran Bretanya)) ;
Hurst, Jacob (University of Oxford) ;
Naidoo, Vanessa (University of KwaZulu-Natal (Durban, Sud-àfrica)) ;
Shapiro, Roger (Botswana Harvard AIDS Institute Partnership (Gaborone, Botswana)) ;
Gary, Kuan-Hsiang Huang (University of Oxford) ;
Frater, John (University of Oxford) ;
Prendergast, Andrew (Queen Mary University of London) ;
Prado, Julia G.. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ndung'u, Thumbi (University of KwaZulu-Natal (Durban, Sud-àfrica)) ;
Walker, Bruce D. (University of Oxford) ;
Carrington, Mary (National Cancer Institute (Maryland, Estats Units d'Amèrica)) ;
Jooste, Pieter (Kimberley Hospital (Northern Cape, Sud-àfrica)) ;
Goulder, Philip J. R. (University of Oxford)
Abstract. HLA class I polymorphism has a major influence on adult HIV disease progression. An important mechanism mediating this effect is the impact on viral replicative capacity (VRC) of the escape mutations selected in response to HLA-restricted CD8+ T-cell responses. [...]
2015 - 10.1371/journal.ppat.1004954
PLOS pathogens, Vol. 11 Núm. 6 (June 2015)
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