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Articles, 12 records found
Articles 12 records found  1 - 10next  jump to record:
1.
11 p, 2.3 MB First-in-human PeriCord cardiac bioimplant : Scalability and GMP manufacturing of an allogeneic engineered tissue graft / Prat-Vidal, Cristina (Institut d'Investigació Biomèdica de Bellvitge - IDIBELL, L'Hospitalet de Llobregat, Spain) ; Rodríguez-Gómez, Luciano (Cell Therapy Service, Banc de Sang i Teixits, Edifici Dr. Frederic Duran i Jordà, Passeig Taulat, 116, 08005 Barcelona, Spain) ; Aylagas, Miriam (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Nieto-Nicolau, Nuria (Barcelona Tissue Bank (BTB), Banc de Sang i Teixits (BST), Barcelona, Spain) ; Gastelurrutia, Paloma (Institut d'Investigació Biomèdica de Bellvitge - IDIBELL, L'Hospitalet de Llobregat, Spain) ; Agustí, Elba (Barcelona Tissue Bank (BTB), Banc de Sang i Teixits (BST), Barcelona, Spain) ; Gálvez-Montón, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Jorba, Ignasi (Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, CIBERES, University of Barcelona, Barcelona, Spain) ; Teis, Albert (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Monguió-Tortajada, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Roura, Santiago (CIBER Cardiovascular, Instituto de Salud Carlos III, Madrid, Spain) ; Vives Armengol, Joaquim (Universitat Autònoma de Barcelona. Departament de Medicina) ; Torrents-Zapata, Silvia (Cell Therapy Service, Banc de Sang i Teixits, Edifici Dr. Frederic Duran i Jordà, Passeig Taulat, 116, 08005 Barcelona, Spain) ; Coca, María Isabel (Cell Therapy Service, Banc de Sang i Teixits, Edifici Dr. Frederic Duran i Jordà, Passeig Taulat, 116, 08005 Barcelona, Spain) ; Reales, Laura (Cell Therapy Service, Banc de Sang i Teixits, Edifici Dr. Frederic Duran i Jordà, Passeig Taulat, 116, 08005 Barcelona, Spain) ; Cámara-Rosell, María Luisa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Cediel, Germán (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Coll, Ruth (Research and Education. Banc de Sang i Teixits, Edifici Dr. Frederic Duran i Jordà, Passeig Taulat, 116, 08005 Barcelona, Spain) ; Farré, Ramon (Unit of Biophysics and Bioengineering, School of Medicine and Health Sciences, University of Barcelona-IDIBAPS-CIBERES, Barcelona, Spain) ; Navajas, Daniel (Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, CIBERES, University of Barcelona, Barcelona, Spain) ; Vilarrodona, Anna (Barcelona Tissue Bank (BTB), Banc de Sang i Teixits (BST), Barcelona, Spain) ; García-López, Joan (Research and Education. Banc de Sang i Teixits, Edifici Dr. Frederic Duran i Jordà, Passeig Taulat, 116, 08005 Barcelona, Spain) ; Muñoz-Guijosa, Christian (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Querol, Sergi (Transfusional Medicine Group, Vall d'Hebron Research Institute, Autonomous University of Barcelona, Barcelona, Spain) ; Bayes-Genis, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina)
Small cardiac tissue engineering constructs show promise for limiting post-infarct sequelae in animal models. This study sought to scale-up a 2-cm 2 preclinical construct into a human-size advanced therapy medicinal product (ATMP; PeriCord), and to test it in a first-in-human implantation. [...]
2020 - 10.1016/j.ebiom.2020.102729
EBioMedicine, Vol. 54 (april 2020)  
2.
13 p, 6.0 MB Mesenchymal stem cells induce expression of cD73 in human monocytes in vitro and in a swine model of myocardial infarction in vivo / Monguió-Tortajada, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Roura, Santiago (Institut Germans Trias i Pujol) ; Gálvez-Montón, Carolina (Institut Germans Trias i Pujol) ; Franquesa, Marcella (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Bayes-Genis, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina) ; Borràs,Francesc E. (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia)
The ectoenzymes CD39 and CD73 regulate the purinergic signaling through the hydrolysis of adenosine triphosphate (ATP)/ADP to AMP and to adenosine (Ado), respectively. This shifts the pro-inflammatory milieu induced by extracellular ATP to the anti- inflammatory regulation by Ado. [...]
2017 - 10.3389/fimmu.2017.01577
Frontiers in immunology, Vol. 8 (november 2017) , p. 1-13  
3.
12 p, 3.6 MB Electromechanical Conditioning of Adult Progenitor Cells Improves Recovery of Cardiac Function After Myocardial Infarction / Lluciá Valldeperas, Aida (Institut Germans Trias i Pujol) ; Soler Botija, Carolina (Institut Germans Trias i Pujol) ; Gálvez Montón, Carolina (Institut Germans Trias i Pujol) ; Roura, Santiago (Institut Germans Trias i Pujol) ; Prat Vidal, Cristina (Institut Germans Trias i Pujol) ; Perea Gil, Isaac (Institut Germans Trias i Pujol) ; Sanchez, Benjamin (Universitat Politècnica de Catalunya. Departament d'Enginyeria Electrònica) ; Bragos, Ramón (Universitat Politècnica de Catalunya. Departament d'Enginyeria Electrònica) ; Vunjak-Novakovic, Gordana (Columbia University. Biomedical Engineering and Medicine) ; Bayes Genis, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina)
Cardiac cells are subjected to mechanical and electrical forces, which regulate gene expression and cellular function. Therefore, in vitro electromechanical stimuli could benefit further integration of therapeutic cells into the myocardium. [...]
2017 - 10.5966/sctm.2016-0079
Stem cells translational medicine, Vol. 6 (2017) , p. 970-981  
4.
9 p, 3.9 MB Noninvasive Assessment of an Engineered Bioactive Graft in Myocardial Infarction: Impact on Cardiac Function and Scar Healing / Gálvez Montón, Carolina (Institut Germans Trias i Pujol. ICREC) ; Bragós, Ramón (Universitat Politècnica de Catalunya. Departament d'Enginyeria Electrònica) ; Soler Botija, Carolina (Institut Germans Trias i Pujol. ICREC) ; Díaz-Güemes, Idoia (Centro de Cirugía de Mínima Invasión Jesús Usón) ; Prat Vidal, Cristina (Institut Germans Trias i Pujol. ICREC) ; Crisóstomo, Verónica (Centro de Cirugía de Mínima Invasión Jesús Usón) ; Sánchez Margallo, Francisco M. (Centro de Cirugía de Mínima Invasión Jesús Usón) ; Llucià Vallperas, Aida (Institut Germans Trias i Pujol. ICREC) ; Bogónez Franco, Francisco Carlos (Universitat Politècnica de Catalunya. Departament d'Enginyeria Electrònica) ; Perea Gil, Isaac (Institut Germans Trias i Pujol. ICREC) ; Roura, Santiago (Institut Germans Trias i Pujol. ICREC) ; Bayes Genis, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina)
Cardiac tissue engineering, which combines cells and biomaterials, is promising for limiting the sequelae of myocardial infarction (MI). We assessed myocardial function and scar evolution after implanting an engineered bioactive impedance graft (EBIG) in a swine MI model. [...]
2017 - 10.5966/sctm.2016-0063
Stem cells translational medicine, Vol. 6 (2017) , p. 647-655  
5.
15 p, 2.3 MB Nanosized UCMSC-derived extracellular vesicles but not conditioned medium exclusively inhibit the inflammatory response of stimulated T cells: implications for nanomedicine / Monguió Tortajada, Marta (Institut Germans Trias i Pujol) ; Roura, Santiago (Institut Germans Trias i Pujol) ; Gálvez Montón, Carolina (Institut Germans Trias i Pujol) ; Pujal, Josep Maria (Universitat de Girona. Laboratori de processament cel·lular) ; Aran Canals, Gemma (Institut Germans Trias i Pujol) ; Sanjurjo, Lucía (Institut Germans Trias i Pujol) ; Franquesa, Marcel·la (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Sarrias, Maria-Rosa (Institut Germans Trias i Pujol) ; Bayes Genis, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina) ; Borràs, Francesc E. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Undesired immune responses have drastically hampered outcomes after allogeneic organ transplantation and cell therapy, and also lead to inflammatory diseases and autoimmunity. Umbilical cord mesenchymal stem cells (UCMSCs) have powerful regenerative and immunomodulatory potential, and their secreted extracellular vesicles (EVs) are envisaged as a promising natural source of nanoparticles to increase outcomes in organ transplantation and control inflammatory diseases. [...]
2017 - 10.7150/thno.16154
, Vol. 7 Núm. 2 (2017) , p. 270-284  
6.
13 p, 3.7 MB A Cell-Enriched Engineered Myocardial Graft Limits Infarct Size and Improves Cardiac Function / Perea-Gil, Isaac (Institut Germans Trias i Pujol) ; Prat-Vidal, Cristina (Institut Germans Trias i Pujol) ; Gálvez-Montón, Carolina (Institut Germans Trias i Pujol) ; Roura, Santiago (Center of Regenerative Medicine in Barcelona, Barcelona, Spain) ; Llucià-Valldeperas, Aida (Institut Germans Trias i Pujol) ; Soler-Botija, Carolina (Institut Germans Trias i Pujol) ; Iborra Egea, Oriol (Institut Germans Trias i Pujol) ; Díaz-Güemes, Idoia (Jesús Usón Minimally Invasive Surgery Centre, JUMISC, Cáceres, Spain) ; Crisóstomo, Verónica (Jesús Usón Minimally Invasive Surgery Centre, JUMISC, Cáceres, Spain) ; Sánchez-Margallo, Francisco M. (Jesús Usón Minimally Invasive Surgery Centre, JUMISC, Cáceres, Spain) ; Bayes-Genis, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina)
Myocardial infarction (MI) remains a dreadful disease around the world, causing irreversible sequelae that shorten life expectancy and reduce quality of life despite current treatment. Here, the authors engineered a cell-enriched myocardial graft, composed of a decellularized myocardial matrix refilled with adipose tissue-derived progenitor cells (EMG-ATDPC). [...]
2016 - 10.1016/j.jacbts.2016.06.005
JACC: Basic to Translational Science, Vol. 1 (august 2016) , p. 360-372  
7.
8 p, 964.1 KB Telomere attrition in heart failure : a flow-FISH longitudinal analysis of circulating monocytes / Teubel, Iris (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Elchinova, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Roura, Santiago (Madrid, Spain) ; Fernández, Marco A. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Gálvez-Montón, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Moliner, Pedro (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; de Antonio, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Lupón, Josep (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Bayés-Genís, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina)
Cross-sectional investigations report shorter telomeres in patients with heart failure (HF); however, no studies describe telomere length (TL) trajectory and its relationship with HF progression. Here we aimed to investigate telomere shortening over time and its relationship to outcomes. [...]
2018 - 10.1186/s12967-018-1412-z
Journal of translational medicine, Vol. 16 (february 2018)  
8.
12 p, 2.1 MB Unravelling the effects of mechanical physiological conditioning on cardiac adipose tissue-derived progenitor cells in vitro and in silico / Llucià Valldeperas, Aida (Institut Germans Trias i Pujol) ; Bragós, Ramon (Universitat Politècnica de Catalunya. Departament d'Enginyeria Electrònica) ; Soler Botija, Carolina (Institut Germans Trias i Pujol) ; Roura, Santiago (Institut Germans Trias i Pujol) ; Gálvez Montón, Carolina (Institut Germans Trias i Pujol) ; Prat Vidal, Cristina (Institut Germans Trias i Pujol) ; Perea Gil, Isaac (Institut Germans Trias i Pujol) ; Bayés Genís, Antoni (Institut Germans Trias i Pujol) ; Universitat Autònoma de Barcelona
Mechanical conditioning is incompletely characterized for stimulating therapeutic cells within the physiological range. We sought to unravel the mechanism of action underlying mechanical conditioning of adipose tissue-derived progenitor cells (ATDPCs), both in vitro and in silico. [...]
2018 - 10.1038/s41598-017-18799-5
Scientific reports, Vol. 8 (january 2018)  
9.
9 p, 1.3 MB Mechanisms of action of sacubitril/valsartan on cardiac remodeling : a systems biology approach / Iborra-Egea, Oriol (Institut Germans Trias i Pujol) ; Gálvez-Montón, Carolina (Institut Germans Trias i Pujol) ; Roura, Santiago (Institut Germans Trias i Pujol) ; Perea-Gil, Isaac (Institut Germans Trias i Pujol) ; Prat-Vidal, Cristina (Institut Germans Trias i Pujol) ; Soler-Botija, Carolina (Institut Germans Trias i Pujol) ; Bayes-Genis, Antoni (Institut Germans Trias i Pujol) ; Universitat Autònoma de Barcelona
Sacubitril/Valsartan, proved superiority over other conventional heart failure management treatments, but its mechanisms of action remains obscure. In this study, we sought to explore the mechanistic details for Sacubitril/Valsartan in heart failure and post-myocardial infarction remodeling, using an in silico, systems biology approach. [...]
2017 - 10.1038/s41540-017-0013-4
NPJ Systems Biology and Applications, Vol. 3 (april 2017)  
10.
10 p, 723.5 KB Extracellular vesicles do not contribute to higher circulating levels of soluble 1 in idiopathic dilated cardiomyopathy / Roura, Santiago (Institut Germans Trias i Pujol. ICREC) ; Gálvez Montón, Carolina (Institut Germans Trias i Pujol. ICREC) ; de Gonzalo Calvo, David (Institut d'Investigació Biomèdica Sant Pau) ; Valero, Ana Gámez (Institut Germans Trias i Pujol) ; Gastelurrutia, Paloma (Institut Germans Trias i Pujol. ICREC) ; Revuelta López, Elena (Institut Germans Trias i Pujol. ICREC) ; Prat Vidal, Cristina (Institut Germans Trias i Pujol. ICREC) ; Soler Botija, Carolina (Institut Germans Trias i Pujol. ICREC) ; Llucià Valldeperas, Aida (Institut Germans Trias i Pujol. ICREC) ; Perea Gil, Isaac (Institut Germans Trias i Pujol. ICREC) ; Iborra Egea, Oriol (Institut Germans Trias i Pujol. ICREC) ; Borràs, Francesc E. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Lupón, Josep (Universitat Autònoma de Barcelona. Departament de Medicina) ; Llorente Cortés, Vicenta (Institut d'Investigació Biomèdica Sant Pau) ; Bayes Genis, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina) ; Universitat Autònoma de Barcelona
Idiopathic dilated cardiomyopathy () is a frequent cause of heart transplantation. Potentially valuable blood markers are being sought, and low-density lipoprotein receptor-related protein 1 (1) has been linked to the underlying molecular basis of the disease. [...]
2017 - 10.1111/jcmm.13211
Journal of Cellular and Molecular Medicine, Vol. 21 (may 2017) , p. 3000-3009  

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