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1.
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15 p, 2.7 MB |
Plasma proteomic profiling identifies CD33 as a marker of HIV control in natural infection and after therapeutic vaccination
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Duran-Castells, Clara (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Prats, Anna (Institut Germans Trias i Pujol. Fundació Lluita Contra les Infeccions) ;
Oriol-Tordera, Bruna (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Llano Montero, Anuska (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Gálvez, Cristina (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ballana, Ester (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
García Vidal, Edurne (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Muñoz-Moreno, Jose A. (Institut Germans Trias i Pujol. Fundació Lluita Contra les Infeccions) ;
Hanke, Thomas (University of Oxford. The Jenner Institute) ;
Moltó, José (Institut Germans Trias i Pujol. Fundació Lluita Contra les Infeccions) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Brander, Christian (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Ruiz Riol, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
Biomarkers predicting the outcome of HIV-1 virus control in natural infection and after therapeutic interventions in HIV-1 cure trials remain poorly defined. The BCN02 trial (NCT02616874), combined a T-cell vaccine with romidepsin (RMD), a cancer-drug that was used to promote HIV-1 latency reversal and which has also been shown to have beneficial effects on neurofunction. [...]
2023 -  10.1016/j.ebiom.2023.104732
EBioMedicine, Vol. 95 (september 2023)
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2.
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13 p, 849.9 KB |
Altered T-cell subset distribution in the viral reservoir in HIV-1-infected individuals with extremely low proviral DNA (LoViReTs)
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Gálvez, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Urrea, Víctor (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
García Guerrero, María del Carmen (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bernal, Sílvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Benet, Susana (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bailón, Lucía (Institut Germans Trias i Pujol. Fundació Lluita Contra les Infeccions) ;
Dalmau, Judith (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martinez, Andrea (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Nieto Gil-Ortega, Aroa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Leal, Lorna (Hospital Clínic i Provincial de Barcelona) ;
García, Felipe (Hospital Clínic i Provincial de Barcelona) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Salgado, Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
HIV cure strategies aim to eliminate viral reservoirs that persist despite successful antiretroviral therapy (ART). We have previously described that 9% of HIV-infected individuals who receive ART harbor low levels of provirus (LoViReTs). [...]
2022 - 10.1111/joim.13484
Journal of Internal Medicine, Vol. 292 (march 2022) , p. 308-320
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3.
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17 p, 3.2 MB |
Sirtuin-2, NAD-Dependent Deacetylase, Is a New Potential Therapeutic Target for HIV-1 Infection and HIV-Related Neurological Dysfunction
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Duran-Castells, Clara (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Llano Montero, Anuska (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Kawana-Tachikawa, Ai (National Institute of Infectious Diseases (Tokio)) ;
Prats, Anna (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martinez-Zalacain, Ignacio (Institut d'Investigació Biomèdica de Bellvitge) ;
Kobayashi-Ishihara, Mie (Universitat Pompeu Fabra) ;
Oriol-Tordera, Bruna (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Peña, Ruth (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Gálvez, Cristina (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Silva-Arrieta, Sandra (Silva-Arrieta, Sandra) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Riveira-Muñoz, Eva (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ballana, Ester (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Prado, Julia G. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Sanchez, Jorge (Centro de Investigaciones Tecnologicas Biomedicas y Medioambientales (Perú)) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Hartigan-O'Connor, Dennis (University of California. Department of Medical Microbiology and Immunology) ;
Wyss-Coray, Tony (Stanford University School of Medicine. Department of Neurology and Neurological Science) ;
Meyerhans, Andreas (University of Gothenburg. Department of Infectious Diseases) ;
Gisslén, Magnus (University of Gothenburg. Department of Infectious Diseases) ;
Price, Richard W. (University of California San Francisco. Department of Neurology) ;
Soriano-Mas, Carles (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut) ;
Muñoz-Moreno, José Antonio (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ruiz Riol, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
The implementation and access to combined antiretroviral treatment (cART) have dramatically improved the quality of life of people living with HIV (PLWH). However, some comorbidities, such as neurological disorders associated with HIV infection still represent a serious clinical challenge. [...]
2023 - 10.1128/jvi.01655-22
Journal of Virology, Vol. 97 (January 2023)
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4.
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11 p, 2.0 MB |
Enhancement of Antiviral CD8 + T-Cell Responses and Complete Remission of Metastatic Melanoma in an HIV-1-Infected Subject Treated with Pembrolizumab
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Blanch-Lombarte, Oscar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Gálvez, Cristina (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Revollo, Boris (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Jiménez-Moyano, Esther (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Llibre, Josep M.. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Manzano, José Luís (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Boada, Aram (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Dalmau, Judith (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
E. Speiser, Daniel (University of Lausanne, Switzerland) ;
Clotet Sala, Bonaventura (Universitat Autònoma de Barcelona. Departament de Medicina) ;
G. Prado, Julia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Background: Pembrolizumab is an immune checkpoint inhibitor against programmed cell death protein-1 (PD-1) approved for therapy in metastatic melanoma. PD-1 expression is associated with a diminished functionality in HIV-1 specific-CD8 + T cells. [...]
2019 - 10.3390/jcm8122089
Journal of clinical medicine, Vol. 8 (december 2019)
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5.
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11 p, 2.5 MB |
Permanent control of HIV-1 pathogenesis in exceptional elite controllers : a model of spontaneous cure
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Casado, Concepcion (Virología Molecular, Laboratorio de Referencia e Investigación en Retrovirus, Centro Nacional de Microbiología, Instituto de Salud Carlos III) ;
Gálvez, Cristina (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Pernas, María (Virología Molecular, Laboratorio de Referencia e Investigación en Retrovirus, Centro Nacional de Microbiología, Instituto de Salud Carlos III) ;
Tarancon-Diez, Laura (Universidad de Sevilla) ;
Rodriguez, Carmen (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Sanchez-Merino, Víctor (Centro Nacional de Microbiología, Instituto de Salud Carlos III) ;
Vera, Mar (Centro Sanitario Sandoval, Hospital Clínico San Carlos) ;
Olivares, Isabel (Centro Nacional de Microbiología, Instituto de Salud Carlos III) ;
De Pablo-Bernal, Rebeca (Universidad de Sevilla) ;
Merino-Mansilla, Alberto (Centro Nacional de Microbiología, Instituto de Salud Carlos III) ;
Del Romero, Jorge (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Lorenzo-Redondo, Ramon (Northwestern University Feinberg School of Medicine, Chicago, USA) ;
Ruiz-Mateos, Ezequiel (Universidad de Sevilla) ;
Salgado, María (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martinez-Picado, Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Lopez-Galindez, Cecilio (Centro Nacional de Microbiología, Instituto de Salud Carlos III)
Elite controllers (EC) represent a small subset of HIV-1-infected people that spontaneously control viral replication. However, natural virological suppression and absence of immune dysfunction are not always long-term sustained. [...]
2020 - 10.1038/s41598-020-58696-y
Scientific reports, Vol. 10 (february 2020)
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6.
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8 p, 759.1 KB |
Evidence for HIV-1 cure after CCR5 Δ32/Δ32 allogeneic haemopoietic stem-cell transplantation 30 months post analytical treatment interruption : a case report
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Gupta, Ravindra Kumar (Africa Health Research Institute) ;
Peppa, Dimitra (UCL Great Ormond Street Institute of Child Health) ;
Hill, Alison L. (Harvard University. Department for Organismic and Evolutionary Biology) ;
Gálvez, Cristina (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Salgado, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Pace, Matthew (Nuffield Department of Medicine, University of Oxford) ;
McCoy, Laura E. (Division of Infection and Immunity, University College London (UCL)) ;
Griffith, Sarah A. (Division of Infection and Immunity, University College London (UCL)) ;
Thornhill, John (Imperial College London) ;
Alrubayyi, Aljawharah (Nuffield Department of Medicine, University of Oxford) ;
Huyveneers, Laura E. P. (Department of Medical Microbiology, University Medical Center) ;
Nastouli, Eleni (UCL Great Ormond Street Institute of Child Health) ;
Grant, Paul (Department of Virology, UCL Hospitals) ;
Edwards, Simon G.. (Mortimer Market Centre, Department of HIV, Central and North West London NHS Trust) ;
Innes, Andrew J. (Hammersmith Hospital (Londres)) ;
Frater, John (Oxford National Institute for Health Research Biomedical Research Centre) ;
Nijhuis, Monique (Department of Medical Microbiology, University Medical Center) ;
Wensing, Anne Marie J. (Department of Medical Microbiology, University Medical Center) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Olavarria, Eduardo (Mortimer Market Centre, Department of HIV, Central and North West London NHS Trust) ;
Universitat Autònoma de Barcelona
The London patient (participant 36 in the IciStem cohort) underwent allogeneic stem-cell transplantation with cells that did not express CCR5 (CCR5 Δ32/Δ32); remission was reported at 18 months after analytical treatment interruption (ATI). [...]
2020 - 10.1016/S2352-3018(20)30069-2
The lancet. HIV, Vol. 7 (march 2020) , p. e340-e347
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7.
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25 p, 3.6 MB |
Methylation regulation of Antiviral host factors, Interferon Stimulated Genes (ISGs) and T-cell responses associated with natural HIV control
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Oriol-Tordera, Bruna (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Berdasco, Maria (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Llano Montero, Anuska (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Gálvez, Cristina (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Carrillo, Jorge (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Blanco, Julià (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Duran-Castells, Clara (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ganoza, C. (Alberto Hurtado School of Medicine. Universidad Peruana Cayetano Heredia) ;
Sanchez, J. (Centro de Investigaciones Tecnológicas. Biomédicas y Medioambientales. CITBM) ;
Pérez-Álvarez, Núria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Calle, M. Luz (Universitat de Vic - Universitat Central de Catalunya) ;
Sánchez, Alex (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Esteller, M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ruiz Riol, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Universitat Autònoma de Barcelona
GWAS, immune analyses and biomarker screenings have identified host factors associated with in vivo HIV-1 control. However, there is a gap in the knowledge about the mechanisms that regulate the expression of such host factors. [...]
2020 - 10.1371/JOURNAL.PPAT.1008678
PLOS pathogens, Vol. 16 Núm. 8 (june 2020) , p. e1008678
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8.
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17 p, 2.5 MB |
Dissemination of Mycobacterium tuberculosis is associated to a SIGLEC1 null variant that limits antigen exchange via trafficking extracellular vesicles
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Benet, Susana (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Gálvez, Cristina (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Drobniewski, Francis (Imperial College) ;
Kontsevaya, Irina (N.V. Postnikov Samara Region Clinical Tuberculosis Dispensary) ;
Arias, Lilibeth (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Monguió-Tortajada, Marta (Universitat Autònoma de Barcelona) ;
Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Urrea, Víctor (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ong, Ruo-Yan (University of Dundee) ;
Luquín Fernández, Marina (Marina) (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Dupont, Maeva (International associated laboratory (LIA) CNRS "IM-TB/HIV" (1167)) ;
Chojnacki, Jakub (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Dalmau, Judith (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Cardona, Paula (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Neyrolles, Olivier (International associated laboratory (LIA) CNRS "IM-TB/HIV" (1167)) ;
Lugo-Villarino, Geanncarlo (International associated laboratory (LIA) CNRS "IM-TB/HIV" (1167)) ;
Vérollet, Christel (International associated laboratory (LIA) CNRS "IM-TB/HIV" (1167)) ;
Julián Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Furrer, Hansjakob (University of Bern) ;
Günthard, Huldrych F. (University of Zurich) ;
Crocker, Paul R. (University of Dundee) ;
Tapia, Gustavo (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Borràs i Serres, Francesc Enric (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Fellay, Jacques (Lausanne University Hospital) ;
McLaren, Paul J. (University of Manitoba) ;
Telenti, Amalio (The Scripps Research Institute) ;
Cardona, Pere-Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pérez-Álvarez, Núria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Vilaplana, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Izquierdo Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
The identification of individuals with null alleles enables studying how the loss of gene function affects infection. We previously described a non-functional variant in SIGLEC1, which encodes the myeloid-cell receptor Siglec-1/CD169 implicated in HIV-1 cell-to-cell transmission. [...]
2021 - 10.1002/jev2.12046
Journal of extracellular vesicles, Vol. 10 (january 2021)
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9.
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12 p, 1.1 MB |
Extremely low viral reservoir in treated chronically HIV-1-infected individuals
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Gálvez, Cristina (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Urrea, Víctor (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Dalmau, Judith (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Jiménez Valero, Montserrat (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Pérez-Álvarez, Núria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Monceaux, Valérie (Institut Pasteur, Unité HIV Inflammation et Persistance, Paris, France) ;
Huot, Nicolas (Institut Pasteur, Unité HIV Inflammation et Persistance, Paris, France) ;
Leal, Lorna (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
González Soler, Victoria (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
González-Cao, María (Hospital Universitari Dexeus (Barcelona, Catalunya)) ;
Müller-Trutwin, Michaela (Institut Pasteur, Unité HIV Inflammation et Persistance, Paris, France) ;
Sáez-Cirión, Asier (Institut Pasteur, Unité HIV Inflammation et Persistance, Paris, France) ;
García, Felipe (Institut Pasteur, Unité HIV Inflammation et Persistance, Paris, France) ;
Blanco, Julià (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Salgado, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Universitat Autònoma de Barcelona
Small viral reservoirs are found predominantly in HIV-1 controllers and individuals treated during acute/early HIV-1 infection. However, other HIV + individuals could naturally also harbour low viral reservoirs. [...]
2020 - 10.1016/j.ebiom.2020.102830
EBioMedicine, Vol. 57 (june 2020)
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10.
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0 p, 5.4 MB |
Antigen production after latency reversal and expression of inhibitory receptors in CD8+ T cells limit the killing of HIV-1 reactivated cells
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Ruiz, A. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Blanch-Lombarte, Oscar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Jiménez-Moyano, Esther (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ouchi, Dan (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Mothe, Beatriz. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Peña, R. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Gálvez, Cristina (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Genescà Ferrer, Meritxell. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Goulder, P. (Department of Paediatrics. University of Oxford) ;
Barnard, R. (Department of Infectious Disease. Merck and Co. Inc.) ;
Howell, B. (Department of Infectious Disease. Merck and Co. Inc.) ;
Pérez-Álvarez, Núria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Prado, Julia G.. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Universitat Autònoma de Barcelona
The so-called shock and kill therapies aim to combine HIV-1 reactivation by latency-reversing agents (LRA) with immune clearance to purge the HIV-1 reservoir. The clinical use of LRA has demonstrated detectable perturbations in the HIV-1 reservoir without measurable reductions to date. [...]
2019 - 10.3389/fimmu.2018.03162
Frontiers in immunology, Vol. 10 Núm. JAN (2019) , p. 3162
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