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16 p, 3.8 MB |
Genetic and phenotypic attributes of splenic marginal zone lymphoma
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Bonfiglio, Ferdinando (Institute of Oncology Research, Bellinzona, Switzerland) ;
Bruscaggin, Alessio (Institute of Oncology Research, Bellinzona, Switzerland) ;
Guidetti, Francesca (Institute of Oncology Research, Bellinzona, Switzerland) ;
Terzi di Bergamo, Lodovico (Institute of Oncology Research, Bellinzona, Switzerland) ;
Faderl, Martin (Institute of Oncology Research, Bellinzona, Switzerland) ;
Spina, Valeria (Institute of Oncology Research, Bellinzona, Switzerland) ;
Condoluci, Adalgisa (Institute of Oncology Research, Bellinzona, Switzerland) ;
Bonomini, Luisella (International Extranodal Lymphoma Study Group, Bellinzona, Switzerland) ;
Forestieri, Gabriela (Institute of Oncology Research, Bellinzona, Switzerland) ;
Koch, Ricardo (Institute of Oncology Research, Bellinzona, Switzerland) ;
Piffaretti, Deborah (Institute of Oncology Research, Bellinzona, Switzerland) ;
Pini, Katia (Institute of Oncology Research, Bellinzona, Switzerland) ;
Pirosa, Maria Cristina (Division of Hematology, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland) ;
Cittone, Micol Giulia (Division of Hematology, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland) ;
Arribas, Alberto (Lymphoma Genomics, Institute of Oncology Research, Bellinzona, Switzerland) ;
Lucioni, Marco (Fondazione IRCCS Policlinico San Matteo and Università degli Studi di Pavia, Pavia, Italy) ;
Ghilardi, Guido (Division of Hematology, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.) ;
Wu, Wei (Institute of Oncology Research, Bellinzona, Switzerland) ;
Arcaini, Luca (University of Pavia, Pavia, Italy.) ;
Baptista, Maria Joao (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bastidas-Mora, Gabriela (Hospital Clínic i Provincial de Barcelona) ;
Bea, Sílvia (Hospital Clínic i Provincial de Barcelona) ;
Boldorini, Renzo (University of Eastern Piedmont, Novara, Italy) ;
Broccoli, Alessandro (IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia Seràgnoli, Bologna, Italy.) ;
Buehler, Marco Matteo (University Hospital Zurich, Switzerland) ;
Canzonieri, Vincenzo (Pathology Unit, CRO Aviano National Cancer Institute, Aviano, Italy) ;
Cascione, Luciano (Institute of Oncology Research, Bellinzona, Switzerland) ;
Ceriani, Luca (Clinic of Nuclear Medicine and PET-CT Centre, Imaging Institute of Southern Switzerland, Bellinzona, Switzerland) ;
Cogliatti, Sergio (Institute of Pathology, Kantonsspital St Gallen, St Gallen, Switzerland) ;
Corradini, Paolo (Division of Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy) ;
Derenzini, Enrico (European Institute of Oncology (IEO) IRCCS, Milan, Italy) ;
Devizzi, Liliana (Division of Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Italy) ;
Dietrich, Sascha (University Hospital Heidelberg, Germany) ;
Elia, Angela Rita (Institute of Oncology Research, Bellinzona, Switzerland) ;
Facchetti, Fabio (Pathology Unit, Spedali Civili, Brescia, Italy) ;
Gaidano, Gianluca (University of Eastern Piedmont, Novara, Italy) ;
Garcia, Juan Fernando (MD Anderson Cancer Center, Madrid) ;
Gerber, Bernhard (Division of Hematology, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland) ;
Ghia, Paolo (IRCCS Ospedale San Raffaele and Università Vita-Salute San Raffaele, Milan, Italy) ;
Gomes da Silva, Maria (Instituto Português de Oncologia de Lisboa, Portugal) ;
Gritti, Giuseppe (Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy) ;
Guidetti, Anna (Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Italy) ;
Hitz, Felicitas (Kantonsspital St Gallen, St Gallen, Switzerland) ;
Inghirami, Giorgio (Weill Cornell Medical College, New York) ;
Ladetto, Marco (Azienda Ospedaliera SS Antonio e Biagio, Alessandria, Italy) ;
Lopez-Guillermo, Armando (Hospital Clínic i Provincial de Barcelona) ;
Lucchini, Elisa (Azienda Sanitaria Universitaria Giuliano Isontina, Trieste, Italy) ;
Maiorana, Antonino (Universitá degli Studi di Modena e Reggio Emilia, Modena, Italy) ;
Marasca, Roberto (University of Modena and Reggio Emilia, Modena, Italy) ;
Matutes, Estella (Hospital Clínic i Provincial de Barcelona) ;
Meignin, Veronique (Saint Louis Hospital, Paris, France) ;
Merli, Michele (University of Insubria and ASST Sette Laghi, Ospedale di Circolo of Varese, Varese, Italy) ;
Moccia, Alden (Oncology Institute of Southern Switzerland, Bellinzona, Switzerland) ;
Mollejo, Manuela (Hospital Virgen de la Salud (Toledo)) ;
Montalban, Carlos (MD Anderson Cancer Center, Madrid) ;
Novak, Urban (University of Bern, Bern, Switzerland) ;
Oscier, David Graham (University Hospitals Dorset, Bournemouth, United Kingdom) ;
Passamonti, Francesco (University of Insubria) ;
Piazza, Francesco (Ospedale Universitario di Padova, Italy) ;
Pizzolitto, Stefano (General Hospital S Maria della Misericordia, Udine, Italy) ;
Rambaldi, Alessandro (Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy) ;
Sabattini, Elena (University of Bologna, Italy) ;
Salles, Gilles (Université de Lyon, France) ;
Santambrogio, Elisa (Candiolo Cancer Institute (FPO-IRCCS), Candiolo, Turin, Italy) ;
Scarfò, Lydia (IRCCS Ospedale San Raffaele and Università Vita-Salute San Raffaele, Milan, Italy) ;
Stathis, Anastasios (Oncology Institute of Southern Switzerland, Bellinzona, Switzerland) ;
Stüssi, Georg (Oncology Institute of Southern Switzerland, Bellinzona, Switzerland) ;
Geyer, Julia T. (Weill Cornell Medical College, New York) ;
Tapia, G. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Tarella, Corrado (European Institute of Oncology (IEO) IRCCS, Milan, Italy) ;
Thieblemont, Catherine (Université de Paris, France) ;
Tousseyn, Thomas (University Hospitals Leuven, Belgium) ;
Tucci, Alessandra (Spedali Civili, Brescia, Italy.) ;
Vanini, Giorgio (University of Bern, Switzerland) ;
Visco, Carlo (University of Verona, Italy) ;
Vitolo, Umberto (Candiolo Cancer Institute (FPO-IRCCS), Candiolo, Turin, Italy) ;
Walewska, Renata (University Hospitals Dorset, Bournemouth, United Kingdom) ;
Zaja, Francesco (Azienda Sanitaria Universitaria Giuliano Isontina, Trieste, Italy) ;
Zenz, Thorsten (University Hospital Zurich, Switzerland) ;
Zinzani, Pier Luigi (Università di Bologna, Italy) ;
Khiabanian, Hossein (Rutgers University, New Brunswick) ;
Calcinotto, Arianna (Institute of Oncology Research, Bellinzona, Switzerland) ;
Bertoni, Francesco (Institute of Oncology Research, Bellinzona, Switzerland) ;
Bhagat, Govind (Columbia University, New York, USA) ;
Campo, Elias (Hospital Clínic i Provincial de Barcelona) ;
de Leval, Laurence (Institut Universitaire de Pathologie, Lausanne, Switzerland) ;
Dirnhofer, Stefan (University Hospital Basel (Basilea, Suïssa)) ;
Pileri, Stefano A. (European Institute of Oncology IRCCS, Milan, Italy) ;
Piris, Miguel Angel (Centro de Investigación Biomédica en Red de Cáncer (CIBERONC) Madrid) ;
Traverse-Glehen, Alexandra (Centre Hospitalier Lyon Sud, Lyon, France) ;
Tzankov, Alexander (University Hospital Basel (Basilea, Suïssa)) ;
Paulli, Marco (Fondazione IRCCS Policlinico San Matteo and Università degli Studi di Pavia, Italy) ;
Ponzoni, Maurilio (Ateneo Vita-Salute San Raffaele University and Pathology Unit San Raffaele Scientific Institute, Milan, Italy) ;
Mazzucchelli, Luca (antonal Institute of Pathology, Locarno, Switzerland) ;
Cavalli, Franco (Institute of Oncology Research, Bellinzona, Switzerland; and.) ;
Zucca, Emanuele (International Extranodal Lymphoma Study Group, Bellinzona, Switzerland) ;
Rossi, Davide (Oncology Institute of Southern Switzerland, Bellinzona, Switzerland) ;
Universitat Autònoma de Barcelona
Splenic marginal zone B-cell lymphoma (SMZL) is a heterogeneous clinico-biological entity. The clinical course is variable, multiple genes are mutated with no unifying mechanism, and essential regulatory pathways and surrounding microenvironments are diverse. [...]
2022 -  10.1182/blood.2021012386
Blood, Vol. 139 Núm. 5 (february 2022) , p. 732-747
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9 p, 698.5 KB |
Efficacy of bendamustine and rituximab as first salvage treatment in chronic lymphocytic leukemia and indirect comparison with ibrutinib : A GIMEMA, ERIC and UK CLL FORUM study
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Cuneo, Antonio (St. Anna University Hospital) ;
Follows, George (Cambridge University Hospitals NHS Foundation Trust (Anglaterra)) ;
Rigolin, Gian Matteo (St. Anna University Hospital) ;
Piciocchi, Alfonso (Italian Group for Adult Hematologic Diseases (GIMEMA)) ;
Tedeschi, Alessandra (Niguarda Cancer Center) ;
Trentin, Livio (University of Padua) ;
Perez, Angeles Medina (Hospital Costa del Sol (Marbella)) ;
Coscia, Marta (University of Turin) ;
Laurenti, Luca (Policlinico A. Gemelli) ;
Musuraca, Gerardo (Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST)) ;
Farina, Lucia (Fondazione IRCCS Istituto Nazionale Tumori) ;
Delgado, Alfredo Rivas (Hospital Clínic i Provincial de Barcelona) ;
Orlandi, Ester Maria (Fondazione IRCCS Policlinico San Matteo) ;
Galieni, Piero (Ospedale C. e G. Mazzoni) ;
Mauro, Francesca Romana ("Sapienza" University) ;
Visco, Carlo (San Bortolo Hospital) ;
Amendola, Angela (San Carlo Hospital) ;
Billio, Atto (Azienda Sanitaria dell'Alto Adige) ;
Marasca, Roberto (University of Modena and Reggio Emilia) ;
Chiarenza, Annalisa (Azienda Universitaria Ospedaliera Policlinico Vittorio Emanuele) ;
Meneghini, Vittorio (University Hospital) ;
Ilariucci, Fiorella (Arcispedale S. Maria Nuova) ;
Marchetti, Monia (Cardinal Massaia Hospital) ;
Molica, Stefano (Azienda Ospedaliera Pugliese Ciaccio) ;
Re, Francesca (University Hospital) ;
Gaidano, Gianluca (Università del Piemonte Orientale Amedeo Avogadro) ;
Gonzalez, Marcos (Hospital Universitari IBSAL i CIBERONC) ;
Forconi, Francesco (University Hospital National Health Service Trust) ;
Ciolli, Stefania (Careggi Hospital) ;
Cortelezzi, Agostino (University of Milan) ;
Montillo, Marco (Niguarda Cancer Center) ;
Smolej, Lukas (University Hospital) ;
Schuh, Anna (Oxford University Hospitals NHS Foundation Trust) ;
Eyre, Toby A. (Oxford University Hospitals NHS Foundation Trust) ;
Kennedy, Ben (University Hospitals of Leicester NHS Trust) ;
Bowles, Kris M. (Norwich Medical School) ;
Vignetti, Marco (Italian Group for Adult Hematologic Diseases (GIMEMA)) ;
De La Serna, Javier (Hospital 12 de Octubre (Madrid)) ;
Moreno, Carol (Institut d'Investigació Biomèdica Sant Pau) ;
Foà, Robin ("Sapienza" University) ;
Ghia, Paolo (IRCCS San Raffaele Scientific Institute and Vita-Salute San Raffaele University) ;
Universitat Autònoma de Barcelona
We performed an observational study on the efficacy of bendamustine and rituximab (BR) as first salvage regimen in chronic lymphocytic leukemia (CLL). In an intention-to-treat analysis including 237 patients, the median progression-free survival (PFS) was 25 months. [...]
2018 - 10.3324/haematol.2018.189837
Haematologica, Vol. 103 Núm. 7 (march 2018) , p. 1209-1217
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9 p, 1.3 MB |
Single-agent ibrutinib versus chemoimmunotherapy regimens for treatment-naïve patients with chronic lymphocytic leukemia : A cross-trial comparison of phase 3 studies
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Robak, Tadeusz (Medical University of Lodz) ;
Burger, Jan A. (The University of Texas MD Anderson Cancer Center) ;
Tedeschi, Alessandra (ASST Grande Ospedale Metropolitano Niguarda) ;
Barr, Paul M. (University of Rochester Cancer Center) ;
Owen, Carolyn (University of Calgary) ;
Bairey, Osnat (Tel Aviv University) ;
Hillmen, Peter (St. James's Institute of Oncology) ;
Simpson, David (North Shore Hospital) ;
Grosicki, Sebastian (Silesian Medical University) ;
Devereux, Stephen (King's College Hospital NHS Foundation Trust) ;
McCarthy, Helen (Royal Bournemouth Hospital) ;
Coutre, Steven E (Stanford University School of Medicine) ;
Quach, Hang (St. Vincent's Hospital) ;
Gaidano, Gianluca (Amedeo Avogadro University of Eastern Piedmont) ;
Maslyak, Zvenyslava (Institute of Blood Pathology and Transfusion Medicine of the Academy of Medical Sciences of Ukraine) ;
Stevens, Don A. (Norton Cancer Institute) ;
Moreno, Carol (Institut d'Investigació Biomèdica Sant Pau) ;
Gill, Devinder S. (Princess Alexandra Hospital) ;
Flinn, Ian W. (Sarah Cannon Research Institute/Tennessee Oncology) ;
Gribben, John G. (Queen Mary University of London) ;
Mokatrin, Ahmad (Pharmacyclics LLC. an AbbVie Company) ;
Cheng, Mei (Pharmacyclics LLC. an AbbVie Company) ;
Styles, Lori (Pharmacyclics LLC. an AbbVie Company) ;
James, Danelle F. (Pharmacyclics LLC. an AbbVie Company) ;
Kipps, Thomas J (University of California San Diego) ;
Ghia, Paolo (Università Vita-Salute San Raffaele and IRCCS Istituto Scientifico San Raffaele) ;
Universitat Autònoma de Barcelona
Chemoimmunotherapy (CIT) and targeted therapy with single-agent ibrutinib are both recommended first-line treatments for chronic lymphocytic leukemia (CLL), although their outcomes have not been directly compared. [...]
2018 - 10.1002/ajh.25259
American Journal of Hematology, Vol. 93 Núm. 11 (november 2018) , p. 1402-1410
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1 p, 825.9 KB |
Correction : Different prognostic impact of recurrent gene mutations in chronic lymphocytic leukemia depending on IGHV gene somatic hypermutation status: a study by ERIC in HARMONY
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Mansouri, Larry (Karolinska Institutet (Estocolm, Suècia)) ;
Thorvaldsdottir, Birna (Karolinska Institutet (Estocolm, Suècia). Department of Molecular Medicine and Surgery) ;
Sutton, Lesley-Ann (Karolinska Institutet (Estocolm, Suècia)) ;
Karakatsoulis, Georgios (University of Ioannina) ;
Meggendorfer, Manja (MLL Munich Leukemia Laboratory) ;
Parker, Helen (University of Southampton) ;
Nadeu, Ferran (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Brieghel, Christian (Copenhagen University Hospital) ;
Laidou, Stamatia (Institute of Applied Biosciences) ;
Moia, Riccardo (Università del Piemonte Orientale) ;
Rossi, Davide (Institute of Oncology Research) ;
Catherwood, Mark (Queen's University Belfast) ;
Kotaskova, Jana (Masaryk University) ;
Delgado, Julio (Hospital Clínic i Provincial de Barcelona) ;
Rodríguez-Vicente, Ana E. (Universidad de Salamanca) ;
Benito, Rocío (Universidad de Salamanca) ;
Rigolin, Gian Matteo (University of Ferrara) ;
Bonfiglio, Silvia (Università Vita Salute San Raffaele) ;
Scarfo, Lydia (Università Vita Salute San Raffaele) ;
Mattsson, Mattias (Uppsala University) ;
Davis, Zadie (University Hospitals Dorset) ;
Gogia, Ajay (All India Institute of Medical Sciences (Nova Delhi, Índia)) ;
Rani, Lata (All India Institute of Medical Sciences (Nova Delhi, Índia)) ;
Baliakas, Panagiotis (Uppsala University) ;
Foroughi-Asl, Hassan (Karolinska Institutet (Estocolm, Suècia)) ;
Jylhä, Cecilia (Karolinska Institutet (Estocolm, Suècia)) ;
Skaftason, Aron (Karolinska Institutet (Estocolm, Suècia)) ;
Rapado, Inmaculada (Centro Nacional de Investigaciones Oncológicas Carlos III (Espanya)) ;
Miras, Fatima (Hospital Universitario 12 de Octubre (Madrid)) ;
Martinez-Lopez, Joaquín (Centro Nacional de Investigaciones Oncológicas Carlos III (Espanya)) ;
de la Serna, Javier (Centro Nacional de Investigaciones Oncológicas Carlos III (Espanya)) ;
Rivas, Jesús María Hernández (Universidad de Salamanca) ;
Thornton, Patrick (Beaumont Hospital (Dublín, Irlanda)) ;
Larráyoz, María José (Universidad de Navarra) ;
Calasanz, M.J (Universidad de Navarra) ;
Fésüs, Viktória (Semmelweis University) ;
Mátrai, Zoltán (Central Hospital of Southern Pest-National Institute of Hematology and Infectious Diseases (Budapest, Hongria)) ;
Bödör, Csaba (Semmelweis University) ;
Smedby, Karin E. (Karolinska Institutet (Estocolm, Suècia)) ;
Espinet, Blanca (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Puiggros, Anna (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Gupta, Ritu (All India Institute of Medical Sciences (Nova Delhi, Índia)) ;
Bullinger, Lars (Charité - Universitätsmedizin Berlin) ;
Bosch José, Francesc Xavier 1947- (Vall d'Hebron Institut d'Oncologia) ;
Tazón-Vega, Bárbara (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Baran-Marszak, Fanny (Hôpital Avicenne AP-HP) ;
Oscier, David (University Hospitals Dorset) ;
Nguyen-Khac, Florence (Sorbonne University) ;
Zenz, Thorsten (University Hospital of Zurich) ;
Terol, Maria Jose (Universitat de València) ;
Cuneo, Antonio (University of Ferrara) ;
Hernández-Sánchez, María (Universidad de Salamanca) ;
Pospisilova, Sarka (Masaryk University) ;
Mills, Ken (Queen's University Belfast) ;
Gaidano, Gianluca (Università del Piemonte Orientale) ;
Niemann, Carsten U. (Copenhagen University Hospital) ;
Campo, Elias (Hospital Clínic i Provincial de Barcelona) ;
Strefford, Jonathan C. (University of Southampton) ;
Ghia, Paolo (Università Vita Salute San Raffaele) ;
Stamatopoulos, Kostas (Institute of Applied Biosciences) ;
Rosenquist, Richard (Karolinska University Hospital and Karolinska Institutet (Suècia))
2023 - 10.1038/s41375-023-01813-3
Leukemia, Vol. 37 (january 2023) , p. 504
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5.
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9 p, 1.7 MB |
Different prognostic impact of recurrent gene mutations in chronic lymphocytic leukemia depending on IGHV gene somatic hypermutation status : a study by ERIC in HARMONY
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Mansouri, Larry (Karolinska Institutet (Estocolm, Suècia)) ;
Thorvaldsdottir, Birna (Karolinska Institutet (Estocolm, Suècia)) ;
Sutton, Lesley-Ann (Karolinska Institutet (Estocolm, Suècia)) ;
Karakatsoulis, Georgios (University of Ioannina. Department of Mathematics) ;
Meggendorfer, Manja (MLL Munich Leukemia Laboratory) ;
Parker, Helen (University of Southampton) ;
Nadeu, Ferran (Centro de Investigación Biomédica en Red de Cáncer) ;
Brieghel, Christian (Copenhagen University Hospital. Department of Hematology, Rigshospitalet) ;
Laidou, Stamatia (Centre for Research and Technology Hellas (Tessalònica, Grècia)) ;
Moia, Riccardo (Università del Piemonte Orientale) ;
Rossi, Davide (Institute of Oncology Research (Suïssa)) ;
Catherwood, Mark (Queen's University Belfast) ;
Kotaskova, Jana (Masaryk University) ;
Delgado, Julio (Universitat de Barcelona) ;
Rodríguez-Vicente, Ana E. (Hospital Universitario de Salamanca) ;
Benito, Rocío (Hospital Universitario de Salamanca) ;
Rigolin, Gian Matteo (University of Ferrara) ;
Bonfiglio, Silvia (Università Vita Salute San Raffaele and IRCCS Ospedale San Raffaele) ;
Scarfo, Lydia (Università Vita Salute San Raffaele) ;
Mattsson, Mattias (Uppsala University. Department of Immunology, Genetics and Pathology) ;
Davis, Zadie (Molecular Pathology Department, University Hospitals Dorset) ;
Gogia, Ajay (All India Institute of Medical Sciences (Nova Delhi, Índia)) ;
Rani, Lata (All India Institute of Medical Sciences (Nova Delhi, Índia)) ;
Baliakas, Panagiotis (Uppsala University. Department of Immunology, Genetics and Pathology) ;
Foroughi-Asl, Hassan (Karolinska Institutet (Estocolm, Suècia)) ;
Jylhä, Cecilia (Karolinska Institutet (Estocolm, Suècia)) ;
Skaftason, Aron (Karolinska Institutet (Estocolm, Suècia)) ;
Rapado, Inmaculada (Spanish National Cancer Research) ;
Miras, Fatima (Hospital Universitario 12 de Octubre (Madrid)) ;
Martinez-Lopez, Joaquín (Spanish National Cancer Research) ;
de la Serna, Javier (Spanish National Cancer Research) ;
Rivas, Jesús María Hernández (Hospital Universitario de Salamanca) ;
Thornton, Patrick (Beaumont Hospital. Haematology Department) ;
Larráyoz, María José (Instituto de Investigación Sanitaria de Navarra) ;
Calasanz, M.J (Instituto de Investigación Sanitaria de Navarra) ;
Fésüs, Viktória (Semmelweis University) ;
Mátrai, Zoltán (Central Hospital of Southern Pest-National Institute of Hematology and Infectious Diseases, Budapest, Hungary) ;
Bödör, Csaba (Semmelweis University) ;
Smedby, Karin E. (Karolinska Institutet (Suècia). Department of Medicine Solna) ;
Espinet, Blanca (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Puiggros, Anna (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Gupta, Ritu (All India Institute of Medical Sciences (Nova Delhi, Índia)) ;
Bullinger, Lars (Charité - Universitätsmedizin Berlin) ;
Bosch José, Francesc Xavier 1947- (Vall d'Hebron Institut d'Oncologia) ;
Tazón-Vega, Bárbara (Vall d'Hebron Institut d'Oncologia) ;
Baran-Marszak, Fanny (Service d'hématologie Biologique Hôpital Avicenne Assistance Publique des Hôpitaux de Paris) ;
Oscier, David (University Hospitals Dorset) ;
Nguyen-Khac, Florence (Sorbonne University) ;
Zenz, Thorsten (University Hospital and University of Zurich. Department of Oncology and Haematology) ;
Terol, Maria Jose (University of Valencia. Department of Hematology) ;
Cuneo, Antonio (University of Ferrara. Hematology-Department of Medical Sciences) ;
Hernández-Sánchez, María (Hospital Universitario de Salamanca) ;
Pospisilova, Sarka (Masaryk University. Central European Institute of Technology) ;
Mills, Ken (Queen's University Belfast) ;
Gaidano, Gianluca (Università del Piemonte Orientale) ;
Niemann, Carsten U. (Copenhagen University Hospital) ;
Campo, Elias (Universitat de Barcelona) ;
Strefford, Jonathan C. (University of Southampton) ;
Ghia, Paolo (Università Vita Salute San Raffaele and IRCCS Ospedale San Raffaele) ;
Stamatopoulos, Kostas (Institute of Applied Biosciences (Grècia)) ;
Rosenquist, Richard (Karolinska University Hospital and Karolinska Institutet (Suècia)) ;
Universitat Autònoma de Barcelona
Recent evidence suggests that the prognostic impact of gene mutations in patients with chronic lymphocytic leukemia (CLL) may differ depending on the immunoglobulin heavy variable (IGHV) gene somatic hypermutation (SHM) status. [...]
2022 - 10.1038/s41375-022-01802-y
Leukemia, Vol. 37 (december 2022) , p. 339-347
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14 p, 502.9 KB |
Presenting features and early mortality from SARS-CoV-2 infection in cancer patients during the initial stage of the COVID-19 pandemic in Europe
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Pinato, David J. (Imperial College London. Department of Surgery & Cancer) ;
Lee, Alvin J. X. (University College London Hospitals) ;
Biello, Federica (University of Piemonte Orientale) ;
Seguí, Elia (Hospital Clínic i Provincial de Barcelona) ;
Aguilar-Company, Juan (Hospital Universitari Vall d'Hebron) ;
Carbó, Anna (Hospital Universitari de Girona Doctor Josep Trueta) ;
Bruna, Riccardo (University of Piemonte Orientale) ;
Bower, Mark (Chelsea & Westminster Hospital) ;
Rizzo, Gianpiero (Fondazione IRCCS Policlinico San Matteo) ;
Benafif, Sarah (University College London Hospitals) ;
Carmona, Carme (Hospital Universitari de Girona Doctor Josep Trueta) ;
Chopra, Neha (University College London Hospitals) ;
Cruz, Claudia Andrea (Hospital Clínic i Provincial de Barcelona) ;
D'avanzo, Francesca (University of Piemonte Orientale) ;
Evans, Joanne S. (Imperial College London) ;
Galazi, Myria (University College London Hospitals) ;
Garcia-Fructuoso, Isabel (Hospital Universitari de Girona Doctor Josep Trueta) ;
Pria, Alessia D. (Chelsea & Westminster Hospital) ;
Newsom-Davis, Thomas (Chelsea & Westminster Hospital) ;
Ottaviani, Diego (University College London Hospitals) ;
Patriarca, Andrea (University of Piemonte Orientale) ;
Reyes, Roxana (Hospital Clínic i Provincial de Barcelona) ;
Sharkey, Rachel (University of Piemonte Orientale) ;
Sng, Christopher C. T. (University College London Hospitals) ;
Wong, Yien Ning Sophia (University College London Hospitals) ;
Ferrante, Daniela (University of Piemonte Orientale) ;
Scotti, Lorenza (University of Piemonte Orientale) ;
Avanzi, Gian Carlo (University of Piemonte Orientale) ;
Bellan, Mattia (University of Piemonte Orientale) ;
Castello, Luigi Mario (University of Piemonte Orientale) ;
Marco-Hernández, Javier (Hospital Clínic i Provincial de Barcelona) ;
Mollà, Meritxell (Hospital Clínic i Provincial de Barcelona) ;
Pirisi, Mario (University of Piemonte Orientale) ;
Ruiz-Camps, Isabel (Hospital Universitari Vall d'Hebron) ;
Sainaghi, Pier Paolo (University of Piemonte Orientale) ;
Gaidano, Gianluca (University of Piemonte Orientale) ;
Brunet, Joan (Hospital Universitari de Girona Doctor Josep Trueta) ;
Tabernero, Josep (Vall d'Hebron Institut d'Oncologia) ;
Prat, Aleix (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Gennari, Alessandra (University of Piemonte Orientale) ;
Universitat Autònoma de Barcelona
We describe the outcomes in cancer patients during the initial outbreak of the COVID-19 in Europe from the retrospective, multi-center observational OnCovid study. We identified 204 cancer patients from eight centers in the United Kingdom, Italy, and Spain aged > 18 (mean = 69) and diagnosed with COVID-19 between February 26th and April 1st, 2020. [...]
2020 - 10.3390/cancers12071841
Cancers, Vol. 12 Núm. 7 (july 2020) , p. 1-13
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15 p, 1.5 MB |
Mutant p53 blocks SESN1/AMPK/PGC-1α/UCP2 axis increasing mitochondrial O· production in cancer cells
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Cordani, Marco (Universidad Autónoma de Madrid. Instituto de Investigaciones Biomédicas "Alberto Sols") ;
Butera, Giovanna (University of Verona. Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biochemistry) ;
Dando, Ilaria (University of Verona. Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biochemistry) ;
Torrens-Mas, Margalida (Institut d'Investigació Sanitària de Palma) ;
Butturini, Elena (University of Verona. Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biochemistry) ;
Pacchiana, Raffaella (University of Verona. Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biochemistry) ;
Oppici, Elisa (University of Verona. Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biochemistry) ;
Cavallini, Chiara (University of Verona. Research Center LURM (Interdepartmental Laboratory of Medical Research)) ;
Gasperini, Sara (Section of General Pathology, University of Verona. Department of Medicine) ;
Tamassia, Nicola (Section of General Pathology, University of Verona. Department of Medicine) ;
Nadal-Serrano, Mercedes (Vall d'Hebron Institut d'Oncologia) ;
Coan, Michela (National Cancer Institute (Aviano, Itàlia)) ;
Rossi, Davide (Institute of Oncology Research) ;
Gaidano, Gianluca (University of Eastern Piedmont. Division of Hematology, Department of Translational Medicine) ;
Caraglia, Michele (Department of Biochemistry, Biophysics and General Pathology, University of Campania "L. Vanvitelli", Naples, Italy) ;
Mariotto, Sofia (University of Verona. Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biochemistry) ;
Spizzo, Riccardo (National Cancer Institute (Aviano, Itàlia)) ;
Roca, Pilar (Institut d'Investigació Sanitària de Palma) ;
Oliver, Jordi (Institut d'Investigació Sanitària de Palma) ;
Scupoli, Maria Teresa (University of Verona. Research Center LURM (Interdepartmental Laboratory of Medical Research)) ;
Donadelli, Massimo (University of Verona. Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biochemistry) ;
Universitat Autònoma de Barcelona
The TP53 tumor suppressor gene is the most frequently altered gene in tumors and mutant p53 gain-of-function isoforms actively promote cancer malignancy. A panel of wild-type and mutant p53 cancer cell lines of different tissues, including pancreas, breast, skin, and lung were used, as well as chronic lymphocytic leukemia (CLL) patients with different TP53 gene status. [...]
2018 - 10.1038/s41416-018-0288-2
British Journal of Cancer, Vol. 119 (october 2018) , p. 994-1008
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11 p, 693.2 KB |
ERIC recommendations for TP53 mutation analysis in chronic lymphocytic leukemia-update on methodological approaches and results interpretation
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Malcikova, J. (Brno, Czech Republic) ;
Tausch, E. (Ulm, Germany) ;
Rossi, Davide (Bellinzona, Switzerland) ;
Sutton, L. A. (Stockholm, Sweden) ;
Soussi, T. (Stockholm, Sweden) ;
Zenz, Thorsten (Zürich, Switzerland) ;
Kater, A. P. (Amsterdam, The Netherlands) ;
Niemann, C. U. (Copenhagen, Denmark) ;
González De Castro, David (Belfast, UK) ;
Davi, F. (Paris, France) ;
Gonzalez Diaz, M. (Salamanca, Spain) ;
Moreno, Carol (Institut d'Investigació Biomèdica Sant Pau) ;
Gaidano, Gianluca (Novara, Italy) ;
Stamatopoulos, K. (Thessaloniki, Greece) ;
Rosenquist, R. (Stockholm, Sweden) ;
Stilgenbauer, S. (Ulm, Germany) ;
Ghia, Paolo (Milan, Italy) ;
Pospisilova, S. (Brno, Czech Republic) ;
Universitat Autònoma de Barcelona
In chronic lymphocytic leukemia (CLL), TP53 gene defects, due to deletion of the 17p13 locus and/or mutation(s) within the TP53 gene, are associated with resistance to chemoimmunotherapy and a particularly dismal clinical outcome. [...]
2018 - 10.1038/s41375-017-0007-7
Leukemia, Vol. 32 (february 2018) , p. 1070-1080
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