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14 p, 563.4 KB |
Clinical management of epidermal growth factor receptor mutation-positive non-small cell lung cancer patients after progression on previous epidermal growth factor receptor tyrosine kinase inhibitors : The necessity of repeated molecular analysis
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González-Larriba, José Luis (Hospital Universitario Clínico San Carlos (Madrid)) ;
Lázaro-Quintela, Martín (Complexo Hospitalario Universitario de Vigo) ;
Cobo, Manuel (Hospital Regional Universitario de Málaga) ;
Dómine, Manuel (Hospital Universitario Fundación Jiménez Díaz) ;
Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau) ;
García-Campelo, Rosario (Complejo Hospitalario Universitario de A Coruña) ;
Universitat Autònoma de Barcelona
One of the most important advances in the treatment of non-small cell lung cancer (NSCLC) has been the identification of molecular alterations vulnerable to targeted inhibition, such as mutations in the epidermal growth factor receptor (EGFR) gene. [...]
2017 -  10.21037/tlcr.2017.10.03
Translational Lung Cancer Research, Vol. 6 (january 2017) , p. S21-S34
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9 p, 902.3 KB |
Assessment of the psychosocial and economic impact according to sex in non-small cell lung cancer patients : an exploratory longitudinal study
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Viñolas, Nuria (Hospital Clínic i Provincial de Barcelona) ;
Garcia-Campelo, Rosario (Complejo Hospitalario Universitario de A Coruña) ;
Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau) ;
Carcereny, Enric (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Isla, Dolores (Hospital Clínico Universitario "Lozano Blesa" de Zaragoza) ;
Gonzalez-Larriba, José Luis (Hospital Clínico San Carlos (Madrid)) ;
Coves, Juan (Hospital Universitari Son Llàtzer (Palma de Mallorca, Balears)) ;
De-Castro, Javier (Hospital Universitario La Paz (Madrid)) ;
Domine, Manuel (Hospital Universitario Fundación Jiménez Díaz) ;
Lianes, Piar (Hospital de Mataró. Consorci Sanitari del Maresme) ;
Artal, Ángel (Hospital Universitario Miguel Servet (Saragossa)) ;
Remon, Jordi (CIOCC Barcelona - HM Delfos) ;
Felip, Enriqueta (Hospital Universitari Vall d'Hebron) ;
Garrido, Pilar (Hospital Universitario Ramón y Cajal (Madrid)) ;
Universitat Autònoma de Barcelona
Little is known about the impact of sex on lung cancer patients from the psychological, economic and social perspectives. This study was designed to explore the psychosocial and economic impact according to sex of metastatic non-small cell lung cancer (mNSCLC) in patients and caregivers. [...]
2020 - 10.1186/s40359-020-00489-z
BMC Psychology, Vol. 8 Núm. 1 (december 2020) , p. 123
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16 p, 1.6 MB |
Alectinib after failure to crizotinib in patients with ALK-positive non-small cell lung cancer : results from the Spanish early access program
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Bernabé, Reyes (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Garrido, Pilar (Hospital Universitario Ramón y Cajal (Madrid)) ;
García-Campelo, Rosario (Complejo Hospitalario Universitario de A Coruña) ;
Palmero, Ramón (Hospital Universitari de Bellvitge) ;
Artal, Ángel (Hospital Universitario Miguel Servet (Saragossa)) ;
Bayona, Cristina (Hospital General Yague (Burgos)) ;
Rodríguez-Abreu, Delvys (Hospital Universitario Insular de Gran Canaria) ;
López-Brea, Marta (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ;
Paredes, Alfredo (Hospital de Donostia (Sant Sebastià, País Basc)) ;
Vicente, David (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Sánchez Torres, José Miguel (Hospital Universitario de la Princesa (Madrid)) ;
Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau) ;
Diz Taín, Pilar (Complejo Asistencial Universitario de León) ;
Gordo, Rocío (Roche Farma. S.A.) ;
Coca, Margarita (Roche Farma. S.A.) ;
de Castro, Javier (Hospital Universitario La Paz (Madrid))
This retrospective observational study analyzed the clinical characteristics, treatment patterns and outcomes of 120 patients with advanced ALK-positive nonsmall-cell lung cancer (ALK+ NSCLC) according to data collected between November 2019 and October 2020 in 38 Spanish hospitals. [...]
2022 - 10.18632/oncotarget.28244
Oncotarget, Vol. 13 Núm. 1 (2022) , p. 812-827
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9 p, 402.4 KB |
Gender influence on work satisfaction and leadership for medical oncologists : a survey of the Spanish Society of Medical Oncology (SEOM)
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Elez, Elena (Vall d'Hebron Institut d'Oncologia) ;
Ayala de la Peña, Francisco (Hospital General Universitario Morales Meseguer (Múrcia)) ;
Felip, Enriqueta (Hospital Universitari Vall d'Hebron) ;
García Campelo, Rosario G. (Complexo Hospitalario Universitario) ;
García-Carbonero, Rocío (Hospital Universitario 12 de Octubre (Madrid)) ;
García Donas, J (Centro Integral Oncológico Clara Campal (CIOCC)) ;
González-del-Alba, Aránzazu (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
González-Flores, Encarnación (Hospital Universitario Virgen de las Nieves (Granada)) ;
Hidalgo, Julia (Hospital Lluis Alcanyís de Xativa) ;
Isla, Dolores (Hospital Clínico Universitario "Lozano Blesa" de Zaragoza) ;
Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau) ;
Rodríguez-Lescure, Álvaro (Hospital General Universitario de Elche) ;
Safont, María José (Consorcio Hospital General Universitario Valencia) ;
Santaballa, Ana (Hospital Universitari i Politècnic La Fe (València)) ;
Villacampa Javierre, Guillermo (Vall d'Hebron Institut d'Oncologia) ;
Vera, Ruth (Complejo Hospitalario de Navarra) ;
Garrido, Pilar (Hospital Universitario Ramón y Cajal (Madrid))
Background: Women represent an increasing proportion of the oncology workforce; however, globally this does not translate into leadership roles, reflecting disparities in career opportunities between men and women. [...]
2021 - 10.1016/j.esmoop.2021.100048
ESMO open, Vol. 6 Núm. 2 (april 2021) , p. 100048
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10 p, 616.7 KB |
Treatment strategy optimization for patients with non-small-cell lung cancer harboring EGFR mutation : a Delphi consensus
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Isla, Dolores (Instituto de Investigación Sanitaria de Aragón) ;
De Castro Carpeño, Javier (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ;
García-Campelo, R. (Complejo Hospitalario Universitario de A Coruña) ;
Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau) ;
Vicente, David (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Juan, Óscar (Hospital Universitari i Politècnic La Fe (València))
Aim: To stablish a consensus on the treatment strategy for advanced non-small-cell lung cancer (aNSCLC) with epidermal growth factor receptor mutation (EGFRm) in Spain. Methods: After a systematic literature review, the scientific committee developed 33 statements in 4 fields: molecular diagnosis (10 items); histologic profile and patient clinical characteristics (7 items); first-line (1L) treatment in EGFRm aNSCLC (8 items); and subsequent-line treatment (8 items). [...]
2021 - 10.1007/s12094-020-02518-0
Clinical & Translational Oncology, Vol. 23 Núm. 7 (july 2021) , p. 1304-1313
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13 p, 941.6 KB |
Pretreatment tissue TCR repertoire evenness is associated with complete pathologic response in patients with NSCLC receiving neoadjuvant chemoimmunotherapy
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Casarrubios, Marta (Instituto de Investigación Sanitaria Puerta de Hierro - Segovia de Arana) ;
Cruz-Bermúdez, Alberto (Instituto de Investigación Sanitaria Puerta de Hierro - Segovia de Arana) ;
Nadal, Ernest (Institut Català d'Oncologia) ;
Insa, Amelia (Hospital Clínic Universitari (València)) ;
García Campelo, María del Rosario (Complejo Hospitalario Universitario de A Coruña) ;
Lázaro, Martín (Hospital Universitario de Vigo) ;
Dómine Gómez, Manuel (Hospital Universitario Fundación Jiménez Díaz) ;
Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau) ;
Rodríguez-Abreu, Delvys (Hospital Universitario Insular de Gran Canaria) ;
Martinez-Marti, Alex (Vall d'Hebron Institut d'Oncologia) ;
de Castro, Javier (Hospital Universitario La Paz (Madrid)) ;
Cobo, Manuel (Hospital Regional Universitario de Málaga) ;
López-Vivanco, Guillermo (Hospital Universitario de Cruces (Barakaldo, País Basc)) ;
Del Barco Morillo, Edel (Hospital Universitario de Salamanca) ;
Bernabé, Reyes (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Viñolas, Nuria (Hospital Clínic i Provincial de Barcelona) ;
Barneto Aranda, Isidoro (Hospital Universitario Reina Sofía (Còrdova, Espanya)) ;
Viteri, Santiago (Instituto Oncológico Dr. Rosell. Hospital Universitario Quiron Dexeus) ;
Massuti, Bartomeu (Hospital General Universitario de Alicante (Alacant, País Valencià)) ;
Barquín, Miguel (Instituto de Investigación Sanitaria Puerta de Hierro - Segovia de Arana) ;
Laza-Briviesca, Raquel (Instituto de Investigación Sanitaria Puerta de Hierro - Segovia de Arana) ;
Sierra-Rodero, Belén (Instituto de Investigación Sanitaria Puerta de Hierro - Segovia de Arana) ;
Parra, Edwin R. (The University of Texas. Department of Translational Molecular Pathology) ;
Sanchez-Espiridion, Beatriz (The University of Texas. Department of Translational Molecular Pathology) ;
Rocha, Pedro (The University of Texas. Department of Translational Molecular Pathology) ;
Kadara, Humam (The University of Texas. Department of Translational Molecular Pathology) ;
Wistuba, Ignacio I. (The University of Texas. Department of Translational Molecular Pathology) ;
Romero, Atocha (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Calvo, Virginia (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Provencio, Mariano (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Purpose: Characterization of the T-cell receptor (TCR) repertoire may be a promising source for predictive biomarkers of pathologic response to immunotherapy in locally advanced non-small cell lung cancer (NSCLC). [...]
2021 - 10.1158/1078-0432.CCR-21-1200
Clinical Cancer Research, Vol. 27 Núm. 21 (November 2021) , p. 5878-5890
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11 p, 544.2 KB |
Immune-Related Adverse Events and Corticosteroid Use for Cancer-Related Symptoms Are Associated With Efficacy in Patients With Non-small Cell Lung Cancer Receiving Anti-PD-(L)1 Blockade Agents
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Riudavets, Mariona (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Mosquera, Joaquin (Complejo Hospitalario Universitario de A Coruña) ;
García-Campelo, Rosario (Complejo Hospitalario Universitario de A Coruña) ;
Serra, Jorgina (Institut d'Investigació Biomèdica Sant Pau) ;
Anguera, Georgia (Institut d'Investigació Biomèdica Sant Pau) ;
Gallardo, Pablo (Institut d'Investigació Biomèdica Sant Pau) ;
Sullivan, Ivana (Institut d'Investigació Biomèdica Sant Pau) ;
Barba Joaquin, Andrés (Institut d'Investigació Biomèdica Sant Pau) ;
del Carpio, Luís (Institut d'Investigació Biomèdica Sant Pau) ;
Barnadas i Molins, Agustí (Institut d'Investigació Biomèdica Sant Pau) ;
Gich, Ignasi (Institut d'Investigació Biomèdica Sant Pau) ;
Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau)
Background: Immune-related adverse events (irAEs) have been associated with improved efficacy in advanced non-small cell lung cancer (NSCLC) patients receiving anti-PD-(L)1 blockade agents, while the concurrent use of corticosteroids seems to worsen it. [...]
2020 - 10.3389/fonc.2020.01677
Frontiers in Oncology, Vol. 10 (september 2020)
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15 p, 955.9 KB |
SEOM clinical guidelines for the treatment of non-small cell lung cancer (2018)
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Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau) ;
Juan, Óscar (Hospital Universitari i Politècnic La Fe (València)) ;
Insa, Amelia (Hospital Clínic Universitari (València)) ;
Reguart, Noemi (Hospital Clínic i Provincial de Barcelona) ;
Trigo, J. M. (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia)) ;
Carcereny, Enric (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
García-Campelo, Rosario (Complejo Hospitalario Universitario de A Coruña) ;
García García, Yolanda (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Guirado, M. (Hospital General Universitario de Elche) ;
Provencio, M. (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Universitat Autònoma de Barcelona
Non-small cell lung cancer (NSCLC) accounts for up to 85% of all lung cancers. The last few years have seen the development of a new staging system, diagnostic procedures such as liquid biopsy, treatments like immunotherapy, as well as deeper molecular knowledge; so, more options can be offered to patients with driver mutations. [...]
2018 - 10.1007/s12094-018-1978-1
Clinical & Translational Oncology, Vol. 21 (november 2018) , p. 3-17
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12 p, 942.4 KB |
BIM and mTOR expression levels predict outcome to erlotinib in EGFR-mutant non-small-cell lung cancer
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Karachaliou, Niki (Hospital Universitari Quiron Dexeus (Barcelona, Catalunya)) ;
Codony-Servat, Jordi (Pangaea Biotech (Barcelona, Catalunya)) ;
Teixidó, Cristina (Pangaea Biotech (Barcelona, Catalunya)) ;
Pilotto, Sara (University of Verona (Itàlia)) ;
Drozdowskyj, Ana (Pivotal (Madrid)) ;
Codony Servat, Carles (Pangaea Biotech (Barcelona, Catalunya)) ;
Giménez-Capitán, Ana (Pangaea Biotech (Barcelona, Catalunya)) ;
Molina-Vila, Miguel Ángel (Pangaea Biotech (Barcelona, Catalunya)) ;
Bertrán-Alamillo, Jordi (Pangaea Biotech (Barcelona, Catalunya)) ;
Gervais, Radj (Centre François Baclesse (Caen, França)) ;
Massuti, Bartomeu (Hospital General Universitario de Alicante (Alacant, País Valencià)) ;
Morán, Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau) ;
Felip, Enriqueta (Hospital Universitari Vall d'Hebron) ;
Carcereny, Enric (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
García-Campelo, Rosario (Complejo Hospitalario Universitario de A Coruña) ;
Viteri, Santiago (Hospital Universitari Quiron Dexeus (Barcelona, Catalunya)) ;
González-Cao, María (Hospital Universitari Quiron Dexeus (Barcelona, Catalunya)) ;
Morales-Espinosa, Daniela (Hospital Universitari Quiron Dexeus (Barcelona, Catalunya)) ;
Verlicchi, Alberto (Ospedale Santa Maria delle Croci (Ravenna, Itàlia)) ;
Crisetti, Elisabetta (Institute of Respiratory Diseases. University of Foggia (Itàlia)) ;
Chaib, Imane (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Santarpia, Mariacarmela (Human Pathology Department. University of Messina (Itàlia)) ;
Ramirez, Jose Luis (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bosch-Barrera, J (Hospital Universitari de Girona Doctor Josep Trueta) ;
Cardona Zorrilla, Andrés Felipe (Instituto de Oncología de Clínica del Country (Bogotá, Colòmbia)) ;
De Marinis, Filippo (Istituto Europeo di Oncologia (Milà, Itàlia)) ;
López-Vivanco, Guillermo (Hospital Universitario de Cruces (Barakaldo, País Basc)) ;
Sánchez, José Miguel (Hospital Universitario de la Princesa (Madrid)) ;
Vergnenegre, Alain (Hôpital du Cluzeau (Limoges, França)) ;
Sánchez Hernández, José Javier (Universidad Autónoma de Nuevo León (Mèxic)) ;
Sperduti, Isabella (Istituto Regina Elena Cancer Institute (Roma, Itàlia)) ;
Bria, Emilio (University of Verona (Itàlia)) ;
Rosell, Rafael (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Abstract. BIM is a proapoptotic protein that initiates apoptosis triggered by EGFR tyrosine kinase inhibitors (TKI). mTOR negatively regulates apoptosis and may influence response to EGFR TKI. We examined mRNA expression of BIM and MTOR in 57 patients with EGFR-mutant NSCLC from the EURTAC trial. [...]
2015 - 10.1038/srep17499
Scientific reports, Vol. 7 (December 2015)
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