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6 p, 617.5 KB |
The effect of intracoronary infusion of bone marrow‐derived mononuclear cells on all‐cause mortality in acute myocardial infarction : rationale and design of the trial
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Mathur, Anthony (Queen Mary University of London (UK)) ;
Arnold, Roman (Hospital Clínico Universitario de Valladolid) ;
Assmus, Birgit (Johann‐Wolfgang‐Goethe University (Germany)) ;
Bartunek, Jozef (VZW Cardiovascular Research Center Aalst (Belgium)) ;
Belmans, Ann (KU Leuven—University of Leuven & Universiteit Hasselt (Belgium)) ;
Bönig, Halvard (Johann‐Wolfgang‐Goethe University (Germany)) ;
Crea, Filippo (Catholic University of the Sacred Heart (Italy)) ;
Dimmeler, Stefanie (Johann‐Wolfgang‐Goethe University (Germany)) ;
Dowlut, Sheik (Queen Mary University of London (UK)) ;
Fernández‐Avilés, Francisco (Hospital General Universitario Gregorio Marañón) ;
Galiñanes, Manuel (Hospital Universitari Vall d'Hebron) ;
García Dorado, David (Hospital Universitari Vall d'Hebron) ;
Hartikainen, Juha (Kuopio University Hospital and University of Eastern Finland (Finland)) ;
Hill, Jonathan (King's College Hospital (UK)) ;
Hogardt‐Noll, Annette (t2cure (Germany)) ;
Homsy, Christian (Celyad SA (Belgium)) ;
Janssens, Stefan (University Hospitals Leuven (Belgium)) ;
Kala, Petr (Faculty Hospital and Masaryk University (Czech Republic)) ;
Kastrup, Jens (Rigshospitalet University of Copenhagen (Denmark)) ;
Martin, John (University College London (UK)) ;
Menasche, Philippe (University Paris Descartes. Assistance Publique Hopitaux de Paris (France)) ;
Miklik, Roman (Faculty Hospital and Masaryk University (Czech Republic)) ;
Mozid, Abdul (Barts Heart Centre (UK)) ;
San Román, J. Alberto (Hospital Clínico Universitario de Valladolid) ;
Sanz‐Ruiz, Ricardo (Hospital General Universitario Gregorio Marañón) ;
Tendera, Michal (Medical University of Silesia (Poland)) ;
Wojakowski, Wojtek (Medical University of Silesia (Poland)) ;
Ylä‐Herttuala, Seppo (Kuopio University Hospital and University of Eastern Finland (Finland)) ;
Zeiher, Andreas (Johann‐Wolfgang‐Goethe University (Germany)) ;
Universitat Autònoma de Barcelona
Over the past 13 years bone marrow‐derived mononuclear cells () have been widely investigated for clinical efficacy in patients following acute myocardial infarction (). These early phase trials have used various surrogate markers to judge efficacy and, although promising, the results have been inconsistent. [...]
2017 -  10.1002/ejhf.829
European Journal of Heart Failure, Vol. 19, Issue 11 (November 2017) , p. 1545-1550
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11 p, 1.0 MB |
Cardiomyocyte hypertrophy induced by Endonuclease G deficiency requires reactive oxygen radicals accumulation and is inhibitable by the micropeptide humanin
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Blasco, Natividad (Cell Signaling and Apoptosis group, Universitat de Lleida - IRBLleida, Lleida, Spain) ;
Cámara, Yolanda (Research Group on Neuromuscular and Mitochondrial Diseases, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona and CIBERER, Barcelona, Spain) ;
Núñez, Estefanía (Cardiovascular Proteomics group, Spanish National Center for Cardiovascular Research (CNIC) and CIBERCV Madrid, Spain) ;
Beà, Aida (Cell Signaling and Apoptosis group, Universitat de Lleida - IRBLleida, Lleida, Spain) ;
Barés, Gisel (Cell Signaling and Apoptosis group, Universitat de Lleida - IRBLleida, Lleida, Spain) ;
Forné, Carles (Biostatistics Unit, IRBLleida, Universitat de Lleida, Lleida, Spain) ;
Ruíz-Meana, Marisol (Cardiovascular Diseases Research Group, VHIR and CIBERCV, Barcelona, Spain) ;
Girón, Cristina (Cell Signaling and Apoptosis group, Universitat de Lleida - IRBLleida, Lleida, Spain) ;
Barba, Ignasi (Cardiovascular Diseases Research Group, VHIR and CIBERCV, Barcelona, Spain) ;
García-Arumí, Elena (Research Group on Neuromuscular and Mitochondrial Diseases, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona and CIBERER, Barcelona, Spain) ;
García Dorado, David (Cardiovascular Diseases Research Group, VHIR and CIBERCV, Barcelona, Spain) ;
Vázquez, Jesús (Cardiovascular Proteomics group, Spanish National Center for Cardiovascular Research (CNIC) and CIBERCV Madrid, Spain) ;
Martí Seves, Ramon (Research Group on Neuromuscular and Mitochondrial Diseases, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona and CIBERER, Barcelona, Spain) ;
Llovera, Marta (Cell Signaling and Apoptosis group, Universitat de Lleida - IRBLleida, Lleida, Spain) ;
Sanchis, Daniel (Cell Signaling and Apoptosis group, Universitat de Lleida - IRBLleida, Lleida, Spain)
The endonuclease G gene (Endog), which codes for a mitochondrial nuclease, was identified as a determinant of cardiac hypertrophy. How ENDOG controls cardiomyocyte growth is still unknown. Thus, we aimed at finding the link between ENDOG activity and cardiomyocyte growth. [...]
2018 - 10.1016/j.redox.2018.02.021
Redox biology, Vol. 16 (march 2018) , p. 146-156
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5 p, 5.1 MB |
Life‐threatening and life‐saving inappropriate implantable cardioverter defibrillator shocks
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Pérez Rodon, Jordi (Universitat Autònoma de Barcelona) ;
Doiny, David (Universitat Autònoma de Barcelona) ;
Miranda, Berta (Universitat Autònoma de Barcelona) ;
Rivas Gándara, Nuria (Universitat Autònoma de Barcelona) ;
Roca Luque, Ivo (Universitat Autònoma de Barcelona) ;
Francisco Pascual, Jaume (Universitat Autònoma de Barcelona) ;
Lidón, Rosa Maria (Universitat Autònoma de Barcelona) ;
García Dorado, David (Universitat Autònoma de Barcelona) ;
Moya Mitjans, Angel (Universitat Autònoma de Barcelona)
An implantable cardioverter defibrillator (ICD) lead dislodgement into the right atrium is a dangerous situation, particularly in patients in atrial fibrillation because atrial fibrillation can be sensed as ventricular fibrillation and true ventricular fibrillation induced with an inappropriate shock. [...]
2017 - 10.1002/ccr3.893
Clinical Case Reports, Vol. 5, Issue 4 (April 2017) , p. 521-525
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10 p, 749.9 KB |
New protein–protein interactions of mitochondrial connexin 43 in mouse heart
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Denuc, Amanda (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Núñez, Estefanía (Centro Nacional de Investigaciones Cardiovasculares Carlos III) ;
Calvo, Enrique (Centro Nacional de Investigaciones Cardiovasculares Carlos III) ;
Loureiro, Marta (Centro Nacional de Investigaciones Cardiovasculares Carlos III) ;
Miro‐Casas, Elisabet (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Guarás, Adela (Centro Nacional de Investigaciones Cardiovasculares Carlos III) ;
Vázquez, Jesús (Centro Nacional de Investigaciones Cardiovasculares Carlos III) ;
Garcia Dorado, David (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Connexin 43 (Cx43), the gap junction protein involved in cell‐to‐cell coupling in the heart, is also present in the subsarcolemmal fraction of cardiomyocyte mitochondria. It has been described to regulate mitochondrial potassium influx and respiration and to be important for ischaemic preconditioning protection, although the molecular effectors involved are not fully characterized. [...]
2016 - 10.1111/jcmm.12792
Journal of Cellular and Molecular Medicine, Vol. 20, issue 5 (May 2016) , p. 794-803
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10 p, 365.3 KB |
Hospital and 4‐year mortality predictors in patients with acute pulmonary edema with and without coronary artery disease
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Figueras Bellot, Jaume (Hospital Universitari Vall d'Hebron. Servei de Cardiologia) ;
Bañeras Rius, Jordi (Hospital Universitari Vall d'Hebron. Servei de Cardiologia) ;
Peña‐Gil, Carlos (Complexo Hospitalario Universitario de Vigo. Servicio de Cardiología) ;
Barrabés Riu, José Antonio (Hospital Universitari Vall d'Hebron. Servei de Cardiologia) ;
Rodríguez Palomares, José Fernando (Hospital Universitari Vall d'Hebron. Servei de Cardiologia) ;
Garcia Dorado, David (Hospital Universitari Vall d'Hebron. Servei de Cardiologia) ;
Universitat Autònoma de Barcelona
Long‐term prognosis of acute pulmonary edema () remains ill defined. We evaluated demographic, echocardiographic, and angiographic data of 806 consecutive patients with with () and without coronary artery disease (non‐) admitted from 2000 to 2010. [...]
2016 - 10.1161/JAHA.115.002581
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol. 5, issue 2 (Feb. 2016)
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13 p, 340.4 KB |
ESC working group cellular biology of the heart : position paper: improving the preclinical assessment of novel cardioprotective therapies
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Lecour, Sandrine (Hatter Institute for Cardiovascular Research (Àfrica)) ;
Bøtker, Hans E. (Aarhus Universitetshospital) ;
Condorelli, Gianluigi (Instituto Clinico Humanitas (Milano, Itàlia)) ;
Davidson, Sean M. (Hatter Institute for Cardiovascular Research (Londres, Regne Unit)) ;
García Dorado, David (Universitat Autònoma de Barcelona) ;
Engel, Felix B. (Friedrich-Alexander-Universität Erlangen-Nürnberg) ;
Ferdinandy, Peter (Semmelweis Egyetem. Department of Pharmacology and Pharmacotherapy) ;
Heusch, Gerd (Universitätsklinikum Essen) ;
Madonna, Rosalinda (Università degli Studi "G. d'Annunzio" Chieti) ;
Ovize, Michel (Université Claude Bernard Lyon 1) ;
Ruiz-Meana, Marisol (Vall d'Hebron Institut de Recerca. Departament de Cardiologia) ;
Schulz, Rainer (Justus Liebig-Universität Gießen) ;
Sluijter, Joost P.G. (Universitair Medisch Centrum Utrecht) ;
Van Laake, Linda W. (Universitair Medisch Centrum Utrecht) ;
Yellon, Derek M. (Hatter Institute for Cardiovascular Research (Londres, Regne Unit)) ;
Hausenloy, Derek J. (Hatter Institute for Cardiovascular Research (Londres, Regne Unit))
Ischaemic heart disease (IHD) remains the leading cause of death and disability worldwide. As a result, novel therapies are still needed to protect the heart from the detrimental effects of acute ischaemia–reperfusion injury, in order to improve clinical outcomes in IHD patients. [...]
2014 - 10.1093/cvr/cvu225
Cardiovascular research, Vol. 104, issue 3 (Dec. 2014) , p. 399–411
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12 p, 565.3 KB |
Impact of Triple Therapy in Elderly Patients with Atrial Fibrillation Undergoing Percutaneous Coronary Intervention
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Sambola, Antonia (Hospital Universitari Vall d'Hebron) ;
Mutuberría Urdániz, María (Hospital Universitari Vall d'Hebron) ;
García Del Blanco, Bruno (Hospital Universitari Vall d'Hebron) ;
Alonso, Albert (Hospital Universitari Vall d'Hebron) ;
Barrabés Riu, José Antonio (Hospital Universitari Vall d'Hebron) ;
Bueno, Héctor (Hospital General Universitario Gregorio Marañón) ;
Alfonso, Fernando (Hospital Clínico San Carlos (Madrid)) ;
Cequier, Ángel (Hospital Universitari de Bellvitge) ;
Zueco, Javier (Hospital Universitario Marqués de Valdecilla (Santander)) ;
Rodríguez Leor, Oriol (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Tornos Mas, Pilar (Hospital Universitari Vall d'Hebron) ;
García Dorado, David (Hospital Universitari Vall d'Hebron)
Background and purpose: Selecting an ideal antithrombotic therapy for elderly patients with atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI) can be challenging since they have a higher thromboembolic and bleeding risk than younger patients. [...]
2016 - 10.1371/journal.pone.0147245
PloS one, Vol. 11 Núm. 1 (January 2016)
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