Results overview: Found 5 records in 0.02 seconds.
Articles, 5 records found
Articles 5 records found  
1.
16 p, 5.0 MB Transcriptome innovations in primates revealed by single-molecule long-read sequencing / Ferrández-Peral, Luis (Institut de Biologia Evolutiva (UPF-CSIC)) ; Xiaoyu Zhan (BGI-Shenzhen) ; Alvarez-Estape, Marina (Institut de Biologia Evolutiva (UPF-CSIC)) ; Chiva, Cristina (Centre de Regulació Genòmica) ; Esteller-Cucala, Paula (Institut de Biologia Evolutiva (UPF-CSIC)) ; García Perez, Raquel (Institut de Biologia Evolutiva (UPF-CSIC)) ; Julià, Eva (Centre de Regulació Genòmica) ; Lizano, Esther (Institut Català de Paleontologia Miquel Crusafont) ; Fornas, Òscar (Centre de Regulació Genòmica) ; Sabidó, Eduard (Centre de Regulació Genòmica) ; Li, Qiye (BGI-Shenzhen) ; Marques-Bonet, Tomas (Institut Català de Paleontologia Miquel Crusafont) ; Juan, David (Institut de Biologia Evolutiva) ; Zhang, Guojie
Transcriptomic diversity greatly contributes to the fundamentals of disease, lineage-specific biology, and environmental adaptation. However, much of the actual isoform repertoire contributing to shaping primate evolution remains unknown. [...]
2022 - 10.1101/gr.276395.121
Genome research, Published in Advance July 15, 2022
2 documents
2.
14 p, 1.9 MB Somatic Mutations Detected in Parkinson Disease Could Affect Genes With a Role in Synaptic and Neuronal Processes / Lobón, Irene (Institut de Biologia Evolutiva (Barcelona)) ; Solís-Moruno, Manuel (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ; Juan, David (Institut de Biologia Evolutiva) ; Muhaisen, Ashraf (Universitat de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia) ; Abascal, Federico (Wellcome Trust Sanger Institute) ; Esteller-Cucala, Paula (Institut de Biologia Evolutiva) ; García Perez, Raquel (Institut de Biologia Evolutiva) ; Martí, Maria Josep (Universitat de Barcelona. Departament de Neurologia) ; Tolosa, Eduardo (Universitat de Barcelona. Departament de Neurologia) ; Ávila, Jesús (Centro de Biología Molecular Severo Ochoa) ; Rahbari, Raheleh (Wellcome Trust Sanger Institute) ; Marques-Bonet, Tomas (Institut Català de Paleontologia Miquel Crusafont) ; Casals, Ferran (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ; Soriano García, Eduardo (Institució Catalana de Recerca i Estudis Avançats)
The role of somatic mutations in complex diseases, including neurodevelopmental and neurodegenerative disorders, is becoming increasingly clear. However, to date, no study has shown their relation to Parkinson disease's phenotype. [...]
2022 - 10.3389/fragi.2022.851039
Frontiers in Aging, Vol. 3 (April 2022) , art. 851039  
3.
17 p, 2.4 MB Epigenomic profiling of primate lymphoblastoid cell lines reveals the evolutionary patterns of epigenetic activities in gene regulatory architectures / García Perez, Raquel (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ; Esteller-Cucala, Paula (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ; Mas, Glòria (Centre de Regulació Genòmica) ; Lobón, Irene (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ; Di Carlo, Valerio (Centre de Regulació Genòmica) ; Riera, Meritxell (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ; Kuhlwilm, Martin (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ; Navarro, Arcadi (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ; Blancher, Antoine (Centre de Physiopathologie Toulouse-Purpan) ; Di Croce, Luciano (Centre de Regulació Genòmica) ; Gomez-Skarmeta, José Luis (Centro Andaluz de Biología del Desarrollo) ; Juan, David (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ; Marques-Bonet, Tomas (Institut Català de Paleontologia Miquel Crusafont)
Changes in the epigenetic regulation of gene expression have a central role in evolution. Here, we extensively profiled a panel of human, chimpanzee, gorilla, orangutan, and macaque lymphoblastoid cell lines (LCLs), using ChIP-seq for five histone marks, ATAC-seq and RNA-seq, further complemented with whole genome sequencing (WGS) and whole genome bisulfite sequencing (WGBS). [...]
2021 - 10.1038/s41467-021-23397-1
Nature communications, Vol. 12 (May 2021) , art. 3116  
4.
14 p, 2.4 MB A comparison of gene expression and DNA methylation patterns across tissues and species / Blake, Lauren E. (University of Chicago. Department of Human Genetics (USA)) ; Roux, Julien (Swiss Institute of Bioinformatics (Switzerland)) ; Hernando-Herraez, Irene (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ; Banovich, Nicholas E. (University of Chicago. Department of Human Genetics (USA)) ; García Perez, Raquel (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ; Hsiao, Chiaowen Joyce (University of Chicago. Department of Human Genetics (USA)) ; Eres, Ittai (University of Chicago. Department of Human Genetics (USA)) ; Cuevas, Claudia (University of Chicago. Department of Human Genetics (USA)) ; Marques-Bonet, Tomas (Institut Català de Paleontologia Miquel Crusafont) ; Gilad, Yoav (University of Chicago. Department of Medicine (USA))
Previously published comparative functional genomic data sets from primates using frozen tissue samples, including many data sets from our own group, were often collected and analyzed using nonoptimal study designs and analysis approaches. [...]
2020 - 10.1101/gr.254904.119
Genome research, Vol. 30, Issue 2 (February 2020) , p. 250-262  
5.
21 p, 2.4 MB Differential DNA methylation of vocal and facial anatomy genes in modern humans / Gokhman, David (The Hebrew University of Jerusalem. The Alexander Silberman Institute of Life Sciences. Department of Genetics (Israel)) ; Nissim-Rafinia, Malka (The Hebrew University of Jerusalem. The Alexander Silberman Institute of Life Sciences. Department of Genetics (Israel)) ; Agranat-Tamir, Lily (The Hebrew University of Jerusalem. Department of Statistics (Israel)) ; Housman, Genevieve (Arizona State University. Center for Evolution and Medicine (USA)) ; García Perez, Raquel (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ; Lizano, Esther (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ; Cheronet, Olivia (University of Vienna. Department of Evolutionary Anthropology (Austria)) ; Mallick, Swapan (Howard Hughes Medical Institute. Harvard Medical School (USA)) ; Nieves-Colón, Maria A. (Arizona State University. Center for Evolution and Medicine (USA)) ; Li, Heng (Broad Institute of MIT and Harvard) ; Alpaslan-Roodenberg, Songül (Harvard Medical School. Department of Genetics (USA)) ; Novak, Mario (University College Dublin. Earth Institute and School of Archaeology (Ireland)) ; Gu, Hongcang (Broad Institute of MIT and Harvard) ; Osinski, Jason M. (University at Buffalo. Jacobs School of Medicine and Biomedical Sciences. Department of Biochemistry (USA)) ; Ferrando-Bernal, Manuel (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ; Gelabert, Pere (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ; Lipende, Iddi (Jane Goodall Institute. Gombe Stream Research Center (Tanzania)) ; Mjungu, Deus (Jane Goodall Institute. Gombe Stream Research Center (Tanzania)) ; Kondova, Ivanela (Biomedical Primate Research Centre (Netherlands)) ; Bontrop, Ronald (Biomedical Primate Research Centre (Netherlands)) ; Kullmer, Ottmar (Senckenberg Center of Human Evolution and Paleoecology. Department of Palaeoanthropology and Messel Research (Germany)) ; Weber, Gerhard (University of Vienna. Department of Evolutionary Anthropology (Austria)) ; Shahar, Tal (Shaare Zedek Medical Center. Department of Neurosurgery (Israel)) ; Dvir-Ginzberg, Mona (Hebrew University of Jerusalem. Institute of Dental Sciences. Laboratory of Cartilage Biology (Israel)) ; Faerman, Marina (Hebrew University of Jerusalem. Institute of Dental Sciences. Laboratory of Bioanthropology and Ancient DNA (Israel)) ; Quillen, Ellen E. (Texas Biomedical Research Institute. Department of Genetics (USA)) ; Meissner, Alexander (Harvard University. Department of Stem Cell and Regenerative Biology (USA)) ; Lahav, Yonatan (The Hebrew University Medical School (Israel)) ; Kandel, Leonid (Hadassah - Hebrew University Medical Center. Orthopaedic Department (Israel)) ; Liebergall, Meir (Hadassah - Hebrew University Medical Center. Orthopaedic Department (Israel)) ; Prada, María E. (I.E.S.O. 'Los Salados'. Junta de Castilla y León) ; Vidal, Julio M. (Junta de Castilla y León. Servicio de Cultura de León) ; Gronostajski, Richard M. (University at Buffalo. Jacobs School of Medicine and Biomedical Sciences. Department of Biochemistry (USA)) ; Stone, Anne C. (Arizona State University. Institute of Human Origins) ; Yakir, Benjamin (The Hebrew University of Jerusalem. Department of Statistics (Israel)) ; Lalueza-Fox, Carles (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ; Pinhasi, Ron (University of Vienna. Department of Evolutionary Anthropology (Austria)) ; Reich, David (Howard Hughes Medical Institute. Harvard Medical School (USA)) ; Marques-Bonet, Tomas (Institut Català de Paleontologia Miquel Crusafont) ; Meshorer, Eran (The Hebrew University of Jerusalem. The Edmond and Lily Safra Center for Brain Sciences (Israel)) ; Carmel, Liran (The Hebrew University of Jerusalem. The Alexander Silberman Institute of Life Sciences. Department of Genetics (Israel))
Changes in potential regulatory elements are thought to be key drivers of phenotypic divergence. However, identifying changes to regulatory elements that underlie human-specific traits has proven very challenging. [...]
2020 - 10.1038/s41467-020-15020-6
Nature communications, Vol. 11 (March 2020) , art. 1189  

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