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1.
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13 p, 7.8 MB |
V-Myc Immortalizes Human Neural Stem Cells in the Absence of Pluripotency-Associated Traits
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Pino-Barrio, María José (Universidad Autónoma de Madrid, Departamento de Biología Molecular) ;
García-García, Elisa (Universidad Autónoma de Madrid, Departamento de Biología Molecular) ;
Menéndez Bujan, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Martínez-Serrano, Alberto (Universidad Autónoma de Madrid, Departamento de Biología Molecular)
A better understanding of the molecular mechanisms governing stem cell self-renewal will foster the use of different types of stem cells in disease modeling and cell therapy strategies. Immortalization, understood as the capacity for indefinite expansion, is needed for the generation of any cell line. [...]
2015 -  10.1371/journal.pone.0118499
PloS one, Vol. 10 (march 2015)
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2.
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13 p, 2.4 MB |
Discovery and validation of an NMR-based metabolomic profile in urine as TB biomarker
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Izquierdo-Garcia, José Luis (Universidad Complutense de Madrid) ;
Comella-del-Barrio, Patricia (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Campos-Olivas, Ramón (Centro Nacional de Investigaciones Oncológicas) ;
Villar-Hernández, Raquel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
De Souza Galvão, Maria Luiza (Hospital Universitari Vall d'Hebron) ;
Jiménez-Fuentes, Maria Angeles (Hospital Universitari Vall d'Hebron) ;
Ruiz-Manzano, Juan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Stojanovic, Zoran (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
González, Adela (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Serra-Vidal, Mar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
García-García, Esther (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Muriel-Moreno, Beatriz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Millet, Joan-Pau (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Molina-Pinargote, Israel (Unitat Clínica de Tractament Directament Observat de la Tuberculosi (Barcelona)) ;
Casas, Xavier (Unitat Clínica de Tractament Directament Observat de la Tuberculosi (Barcelona)) ;
Santiago, Javier (Unitat Clínica de Tractament Directament Observat de la Tuberculosi (Barcelona)) ;
Sabriá, Fina (Hospital de Sant Joan Despí Moisès Broggi) ;
Martos, Carmen (Hospital de Sant Joan Despí Moisès Broggi) ;
Herzmann, Christian (Research Center Borstel. Center for Clinical Studies, Germany) ;
Ruiz-Cabello, Jesús (IKERBASQUE, Basque Foundation for Science) ;
Domínguez, José (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Despite efforts to improve tuberculosis (TB) detection, limitations in access, quality and timeliness of diagnostic services in low- and middle-income countries are challenging for current TB diagnostics. [...]
2020 - 10.1038/s41598-020-78999-4
Scientific reports, Vol. 10 (december 2020)
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3.
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11 p, 1.8 MB |
Diagnostic benefits of adding EspC, EspF and Rv2348-B to the QuantiFERON Gold In-tube antigen combination
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Villar-Hernández, Raquel (Universitat Autònoma de Barcelona) ;
Blauenfeldt, Thomas (Statens Serum Institut) ;
García-García, Esther (Universitat Autònoma de Barcelona) ;
Muriel-Moreno, Beatriz (Universitat Autònoma de Barcelona) ;
De Souza Galvão, Maria Luiza (Hospital Universitari Vall d'Hebron) ;
Millet, Joan-Pau (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Sabriá, Fina (Hospital de Sant Joan Despí Moisès Broggi) ;
Sánchez-Montalvá, Adrian (Hospital Universitari Vall d'Hebron) ;
Ruiz-Manzano, Juan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pilarte, J. (Hospital Universitari Vall d'Hebron) ;
Jiménez, M. A. (Hospital Universitari Vall d'Hebron) ;
Centeno Clemente, Carmen Angela (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martos, Carmen (Hospital de Sant Joan Despí Moisès Broggi) ;
Molina-Pinargote, Israel (Unitat Clínica de Tractament Directament Observat de la Tuberculosi (Barcelona)) ;
González-Díaz, Yoel D. (Unitat Clínica de Tractament Directament Observat de la Tuberculosi (Barcelona)) ;
Santiago, Javier (Unitat Clínica de Tractament Directament Observat de la Tuberculosi (Barcelona)) ;
Cantos, Adela (Hospital Universitari Vall d'Hebron) ;
Casas, Irma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Guerola, Rosa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat Aymerich, Cristina (Utrecht University) ;
Andersen, Peter Lawætz (Statens Serum Institut) ;
Latorre, Irene (Universitat Autònoma de Barcelona) ;
Ruhwald, Morten (Statens Serum Institut) ;
Domínguez, Jose (Universitat Autònoma de Barcelona)
Interferon (IFN)-γ release assays (IGRAs) are used to diagnose latent tuberculosis (TB) infection (LTBI). To improve the accuracy of these tests, different approaches, such as alternative cytokine detection and using different antigens, are considered. [...]
2020 - 10.1038/s41598-020-70204-w
Scientific reports, Vol. 10 (august 2020)
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4.
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1.5 MB |
Cell-Mediated Immune Responses to in vivo -Expressed and Stage-Specific Mycobacterium tuberculosis Antigens in Latent and Active Tuberculosis Across Different Age Groups
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Coppola, Mariateresa (Leiden University Medical Center) ;
Villar-Hernández, Raquel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
van Meijgaarden, Krista E. (Leiden University Medical Center) ;
Latorre, Irene (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Muriel-Moreno, Beatriz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
García-García, Esther (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Franken, Kees L. M. C. (Leiden University Medical Center) ;
Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Stojanovic, Zoran (Universitat Autònoma de Barcelona. Departament de Medicina) ;
De Souza Galvão, Maria Luiza (Hospital Universitari Vall d'Hebron) ;
Millet, Joan-Pau (CIBER de Epidemiología y Salud Pública (CIBEREESP)) ;
Sabriá, Josefina (Hospital de Sant Joan Despí Moisès Broggi) ;
Sánchez-Montalva, Adrián (Hospital Universitari Vall d'Hebron) ;
Noguera-Julian, Antoni (Institut de Recerca Sant Joan de Déu) ;
Geluk, Annemieke (Leiden University Medical Center) ;
Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ottenhoff, Tom H. M. (Leiden University Medical Center)
A quarter of the global human population is estimated to be latently infected by Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB). TB remains the global leading cause of death by a single pathogen and ranks among the top-10 causes of overall global mortality. [...]
2020 - 10.3389/fimmu.2020.00103
Frontiers in immunology, Vol. 11 (february 2020)
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5.
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11 p, 1.7 MB |
Use of IP-10 detection in dried plasma spots for latent tuberculosis infection diagnosis in contacts via mail
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Villar-Hernández, Raquel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Latorre, Irene (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
De Souza Galvão, Maria Luiza (Hospital Universitari Vall d'Hebron) ;
Jiménez, María A. (Hospital Universitari Vall d'Hebron) ;
Ruiz Manzano, J (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pilarte, Jose (Hospital Universitari Vall d'Hebron) ;
García-García, Esther (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Muriel-Moreno, Beatriz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cantos, Adela (Hospital Universitari Vall d'Hebron) ;
Altet, Neus (Hospital Universitari Vall d'Hebron) ;
Millet, Joan-Pau (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
González-Díaz, Yoel D. (Unidad Clínica de Tratamiento Directamente Observado "Serveis Clinics") ;
Molina-Pinargote, Israel (Unidad Clínica de Tratamiento Directamente Observado "Serveis Clinics") ;
Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ruhwald, Morten (Statens Serum Institut (Copenhagen, Dinamarca). Department of Infectious Disease Immunology) ;
Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
The aim of this study was to test the use of IP-10 detection in dried plasma from contact studies individuals (contacts of smear positive patients), by comparing it with IP-10 and IFN-γ detection in direct plasma, to establish IP-10 detection in DPS as a useful assay for LTBI diagnosis. [...]
2019 - 10.1038/s41598-019-40778-1
Scientific reports, Vol. 9 Núm. 1 (january 2019) , p. 3943
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6.
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11 p, 1.1 MB |
Immune-mediated inflammatory diseases differently affect IGRAs' accuracy for latent tuberculosis infection diagnosis in clinical practice
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Latorre, Irene (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Mínguez, Sonia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Carrascosa, José Manuel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Naves, Juan Enrique (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Villar-Hernández, Raquel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Muriel-Moreno, Beatriz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
García-García, Esther (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Casas, Irma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Domènech, Eugeni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ferrándiz, Carlos (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Mateo, Lourdes (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Background. Clinical accuracy of IGRAs remains unclear on patients with immune-mediated inflammatory diseases (IMIDs). Here, we assess the impact of immunosuppressants and IMIDs on QuantiFERON-TB Gold In-Tube (QFN-G-IT) and T-SPOT. [...]
2017 - 10.1371/journal.pone.0189202
PloS one, Vol. 12 Núm. 12 (december 2017) , p. 1-11
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7.
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17 p, 1.5 MB |
Assessment of the influence of direct tobacco smoke on infection and active TB management
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Altet, Neus (Hospital Universitari Vall d'Hebron) ;
Latorre, Irene (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Jiménez-Fuentes, María Ángeles (Hospital Universitari Vall d'Hebron) ;
Maldonado, José (Unitat Clínica de Tractament Directament Observat de la Tuberculosi (Barcelona)) ;
Molina Romero, Israel (Unitat Clínica de Tractament Directament Observat de la Tuberculosi (Barcelona)) ;
González-Díaz, Yoel (Unitat Clínica de Tractament Directament Observat de la Tuberculosi (Barcelona)) ;
Milà, Celia (Hospital Universitari Vall d'Hebron) ;
García-García, Esther (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Muriel-Moreno, Beatriz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Villar-Hernández, Raquel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Laabei, Maisem (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gómez Camacho, Andromeda Celeste (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Godoy, Pere (Generalitat de Catalunya. Departament de Salut) ;
De Souza Galvão, Maria Luiza (Hospital Universitari Vall d'Hebron) ;
Solano Reina, Segismundo (Hospital General Universitario Gregorio Marañón) ;
Jiménez-Ruiz, Carlos A. (Comunidad Autónoma de Madrid. Unidad de Tabaquismo) ;
Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
PII Smoking SEPAR Working Group
Background. Smoking is a risk factor for tuberculosis (TB) infection and disease progression. Tobacco smoking increases susceptibility to TB in a variety of ways, one of which is due to a reduction of the IFN-γ response. [...]
2017 - 10.1371/journal.pone.0182998
PloS one, Vol. 12 Núm. 8 (august 2017) , p. 1
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