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9 p, 318.7 KB |
Effect of a Perioperative Hypotension-Avoidance Strategy Versus a Hypertension-Avoidance Strategy on the Risk of Acute Kidney Injury : A Clinical Research Protocol for a Substudy of the POISE-3 Randomized Clinical Trial
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Garg, Amit X. (London Health Sciences Centre) ;
Cuerden, Meaghan (London Health Sciences Centre) ;
Aguado, Hector (Hospital Clínico Universitario de Valladolid) ;
Amir, Mohammed (Shifa International Hospital) ;
Belley-Cote, Emilie P. (McMaster University (Canadà)) ;
Bhatt, Keyur (SIDS Hospital Research Centre) ;
Biccard, Bruce M (Groote Schuur Hospital) ;
Borges, Flavia K. (Population Health Research Institute) ;
Chan, Matthew (The Chinese University of Hong Kong) ;
Conen, David (Population Health Research Institute) ;
Duceppe, Emmanuelle (Population Health Research Institute) ;
Efremov, Sergey (Saint Petersburg State University) ;
Eikelboom, John (McMaster University (Canadà)) ;
Fleischmann, Edith (Medical University of Vienna) ;
Giovanni, Landoni (Istituto Scientifico Universitario San Raffaele) ;
Gross, Peter (McMaster University (Canadà)) ;
Jayaram, Raja (University of Oxford) ;
Kirov, Mikhail (Northern State Medical University of the Ministry of Healthcare of the Russian Federation) ;
Kleinlugtenbelt, Ydo (Deventer Ziekenhuis) ;
Kurz, Andrea (Medical University of Graz) ;
Lamy, Andre (Population Health Research Institute) ;
Leslie, Kate (The Royal Melbourne Hospital) ;
Likhvantsev, Valery (I. M. Sechenov Moscow Medical Academy) ;
Lomivorotov, Vladimir (Novosibirsk State University) ;
Marcucci, Maura (McMaster University (Canadà)) ;
Martinez-Zapata, Maria José (Institut d'Investigació Biomèdica Sant Pau) ;
McGillion, Michael (McMaster University (Canadà)) ;
McIntyre, William (Population Health Research Institute) ;
Meyhoff, Christian (University of Copenhagen) ;
Ofori, Sandra (Population Health Research Institute) ;
Painter, Thomas (Royal Adelaide Hospital) ;
Paniagua, Pilar (Institut d'Investigació Biomèdica Sant Pau) ;
Parikh, Chirag (Johns Hopkins University) ;
Parlow, Joel (Kingston General Hospital) ;
Patel, Ameen (McMaster University (Canadà)) ;
Polanczyk, Carisi (Hospital de Clinicas de Porto Alegre) ;
Richards, Toby (The University of Western Australia) ;
Roshanov, Pavel (Western University) ;
Schmartz, Denis (CHU Brugmann) ;
Sessler, Daniel (Cleveland Clinic) ;
Short, Tim (Auckland District Health Board) ;
Sontrop, Jessica M. (Western University) ;
Spence, Jessica (McMaster University (Canadà)) ;
Srinathan, Sadeesh (University of Manitoba) ;
Stillo, David (Population Health Research Institute) ;
Szczeklik, Wojciech (Jagiellonian University) ;
Tandon, Vikas (McMaster University (Canadà)) ;
Torres, David (Clinica Santa Maria (Chile)) ;
Van Helder, Thomas (Hamilton Health Sciences) ;
Vincent, Jessica (Population Health Research Institute) ;
Wang, C.Y. (University of Malaya) ;
Wang, Michael (McMaster University (Canadà)) ;
Whitlock, Richard (Population Health Research Institute) ;
Wittmann, Maria (Universitätsklinikum Bonn) ;
Xavier, Denis (St. John's National Academy of Health Sciences) ;
Devereaux, P. J (McMaster University (Canadà))
Background: Most patients who take antihypertensive medications continue taking them on the morning of surgery and during the perioperative period. However, growing evidence suggests this practice may contribute to perioperative hypotension and a higher risk of complications. [...]
2022 -  10.1177/20543581211069225
Canadian Journal of Kidney Health and Disease, Vol. 9 (january 2022)
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6 p, 356.0 KB |
Effects of accelerated versus standard care surgery on the risk of acute kidney injury in patients with a hip fracture : A substudy protocol of the hip fracture Accelerated surgical TreaTment and Care tracK (HIP ATTACK) international randomised controlled trial
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Kessler Borges, Flavia (Department of Perioperative Medicine. Population Health Research Institute (Ontario, Canadà)) ;
Devereaux, Philip James (Departments of Health Research Methods. Evidence. and Impact (HEI). McMaster University (Ontario, Canadà)) ;
Cuerden, Meaghan (Western University (Ontario, Canadà)) ;
Bhandari, Mohit (McMaster University (Ontario, Canadà)) ;
Guerra-Farfán, Ernesto (Hospital Universitari Vall d'Hebron) ;
Patel, Ameen (McMaster University (Ontario, Canadà)) ;
Sigamani, Alben (Clinical Research, Narayana Hrudayalaya Limited (Bangalore, Índia)) ;
Umer, Massod (Aga Khan University (Karachi, Pakistan)) ;
Neary, John (McMaster University (Ontario, Canadà)) ;
Tiboni, Maria (McMaster University (Ontario, Canadà)) ;
Tandon, Vikas (McMaster University (Ontario, Canadà)) ;
Ramokgopa, Mmampapatla Thomas (University of the Witwatersrand (Johannesburg, Sud-àfrica)) ;
Sancheti, Parag (Sancheti Institute for Orthopaedics and Rehabilitation (Pune, Índia)) ;
John, Bobby (Christian Medical College. Hospital Ludhiana (Ludhiana, Índia)) ;
Lawendy, AbdelRahman (Western University (Ontario, Canadà)) ;
Balaguer Castro, Mariano (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Jenkinson, Richard (Sunnybrook Health Sciences Centre (Ontario, Canadà)) ;
Ślȩczka, Pawel (Orthopaedic Department. SPZOZ (Myslenice, Polònia)) ;
Nabi Nur, Aamer (Shifa International Hospital (Islamabad, Pakistan)) ;
Wood, Gavin C. A. (Queen's University (Ontario, Canadà)) ;
Feibel, Robert (Division of Orthopaedic Surgery. University of Ottawa (Ontario, Canadà)) ;
McMahon, John Stephen (Markham Stouffville Hospital (Ontario, Canadà)) ;
Sigamani, Alen (Government TD Medical College (Allapuzha, Índia)) ;
Biccard, Bruce M (University of Cape Town (Rondebosch, Sud-àfrica)) ;
Landoni, Giovanni (Vita-Salute San Raffaele University (Milà, Itàlia)) ;
Szczeklik, Wojciech (Jagiellonian University. Medical College (Krakow, Polònia)) ;
Wang, Chew Yin (University Malaya (Kuala Lumpur, Malàisia)) ;
Tomas-Hernandez, Jordi (Hospital Universitari Vall d'Hebron) ;
Abraham, Valsa (Christian Medical College. Hospital Ludhiana (Ludhiana, Índia)) ;
Vincent, Jessica (Population Health Research Institute (Ontario, Canadà)) ;
Harvey, Valerie (Population Health Research Institute (Ontario, Canadà)) ;
Pettit, Shirley (Population Health Research Institute (Ontario, Canadà)) ;
Sontrop, Jessica M. (Western University (Ontario, Canadà)) ;
Garg, Amit (Western University (Ontario, Canadà)) ;
Universitat Autònoma de Barcelona
Introduction Inflammation, dehydration, hypotension and bleeding may all contribute to the development of acute kidney injury (AKI). Accelerated surgery after a hip fracture can decrease the exposure time to such contributors and may reduce the risk of AKI. [...]
2019 - 10.1136/bmjopen-2019-033150
BMJ open, Vol. 9 Núm. 9 (january 2019) , p. e033150
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13 p, 2.9 MB |
Genomic profiling of NETs : A comprehensive analysis of the RADIANT trials
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Yao, James (University of Texas MD Anderson Cancer Center) ;
Garg, Amit (Novartis Institutes for Biomedical Research) ;
Chen, David (Novartis Pharmaceuticals Corporation) ;
Capdevila Castillón, Jaume (Vall d'Hebron Institut d'Oncologia) ;
Engstrom, Paul (Fox Chase Cancer Center) ;
Pommier, Rodney (Oregon Health and Science University) ;
Van Cutsem, Eric (University Hospitals Gasthuisberg (Leuven, Bélgica)) ;
Singh, Simron (Odette Cancer Center. Sunnybrook Health Sciences Center) ;
Fazio, Nicola (European Institute of Oncology) ;
He, Wei (Novartis Pharmaceuticals Corporation) ;
Riester, Markus (Novartis Institutes for Biomedical Research) ;
Patel, Parul (Novartis Pharmaceuticals Corporation) ;
Voi, Maurizio (Novartis Pharmaceuticals Corporation) ;
Morrissey, Michael (Novartis Institutes for Biomedical Research) ;
Pavel, Marianne (University of Erlangen-Nuremberg) ;
Helmut Kulke, Matthew. (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica)) ;
Universitat Autònoma de Barcelona
Neuroendocrine tumors (NETs) have historically been subcategorized according to histologic features and the site of anatomic origin. Here, we characterize the genomic alterations in patients enrolled in three phase 3 clinical trials of NET of different anatomic origins and assess the potential correlation with clinical outcomes. [...]
2018 - 10.1530/ERC-18-0332
Endocrine-Related Cancer, Vol. 26 Núm. 4 (2018), p. 391-403
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12 p, 1.7 MB |
Pharmacokinetic and exposure-response analysis of pertuzumab in patients with HER2-positive metastatic gastric or gastroesophageal junction cancer
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Kirschbrown, Whitney. P. (Clinical Pharmacology. Genentech Research and Early Development) ;
Wang, B. (Clinical Pharmacology. Genentech Research and Early Development) ;
Nijem, I. (Clinical Pharmacology. Genentech Research and Early Development) ;
Ohtsu, A. (Department of Gastrointestinal Oncology. National Cancer Center Hospital East) ;
Hoff, P. M. (Instituto do Câncer de São Paulo. Faculdade de Medicina da Universidade de São Paulo) ;
Shah, M. A. (Medical Oncology/Solid Tumor Program. Sandra and Edward Meyer Cancer Center. Weill Cornell Medical College) ;
Shen, L. (Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing). Department of Gastrointestinal Oncology. Peking University Cancer Hospital and Institute) ;
Kang, Y. K. (Department of Oncology. Asan Medical Center. University of Ulsan College of Medicine) ;
Alsina, Maria (Vall d'Hebron Institut d'Oncologia) ;
Girish, S. (Clinical Pharmacology. Genentech Research and Early Development) ;
Garg, Amit (Clinical Pharmacology. Genentech Research and Early Development) ;
Universitat Autònoma de Barcelona
Purpose: To characterize the pharmacokinetics (PK) of pertuzumab and trastuzumab in patients with HER2-positive metastatic gastric or gastroesophageal junction cancer in the randomized, double-blind, phase III JACOB study (NCT01774786), and to evaluate the appropriateness of the pertuzumab regimen in these patients. [...]
2019 - 10.1007/s00280-019-03871-w
Cancer Chemotherapy and Pharmacology, Vol. 84 Núm. 3 (january 2019) , p. 539-550
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