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14 p, 973.2 KB |
Mo(VI) Potential Metallodrugs : Explaining the Transport and Cytotoxicity by Chemical Transformations
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Mohanty, Monalisa (National Institute of Technology Rourkela) ;
Sahu, Gurunath (National Institute of Technology Rourkela) ;
Banerjee, Atanu (National Institute of Technology Rourkela) ;
Lima, Sudhir (National Institute of Technology Rourkela) ;
Patra, Sushree Aradhana (National Institute of Technology Rourkela) ;
Crochet, Aurélien (University of Fribourg) ;
Sciortino, Giuseppe (Institut d'Investigacions Químiques de Catalunya) ;
Sanna, Daniele (Consiglio Nazionale delle Ricerche. Istituto di Chimica Biomolecolare) ;
Ugone, Valeria (Consiglio Nazionale delle Ricerche. Istituto di Chimica Biomolecolare) ;
Garribba, Eugenio (Università di Sassari. Dipartimento di Medicina, Chirurgia e Farmacia) ;
Dinda, Rupam (National Institute of Technology Rourkela)
The transport and cytotoxicity of molybdenum-based drugs have been explained with the concept of chemical transformation, a very important idea in inorganic medicinal chemistry that is often overlooked in the interpretation of the biological activity of metal-containing systems. [...]
2022 -  10.1021/acs.inorgchem.2c00113
Inorganic chemistry, Vol. 61, Issue 10 (March 2022) , p. 4513-4532
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2.
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17 p, 5.3 MB |
Solution chemical properties and anticancer potential of 8-hydroxyquinoline hydrazones and their oxidovanadium(IV) complexes
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Ribeiro, Nádia (Universidade de Lisboa. Departamento de Engenharia Química) ;
Bulut, Ipek (Koç University. School of Medicine) ;
Pósa, Vivien (University of Szeged. Department of Inorganic and Analytical Chemistry) ;
Sergi, Baris (Koç University. School of Medicine) ;
Sciortino, Giuseppe (Institut d'Investigacions Químiques de Catalunya) ;
Costa Pessoa, João (Universidade de Lisboa. Departamento de Engenharia Química) ;
Maia, Luisa B. (Universidade Nova de Lisboa. LAQV/REQUIMTE) ;
Ugone, Valeria (Consiglio Nazionale delle Ricerche. Istituto di Chimica Biomolecolare) ;
Garribba, Eugenio (Università di Sassari. Dipartimento di Medicina, Chirurgia e Farmacia) ;
Enyedy, Éva A. (University of Szeged. Department of Inorganic and Analytical Chemistry) ;
Acilan, Ceyda (Koç University. School of Medicine) ;
Correia, Isabel (Universidade de Lisboa. Departamento de Engenharia Química)
We report the synthesis and characterization of a family of benzohydrazones (Ln, n = 1-6) derived from 2-carbaldehyde-8-hydroxyquinoline and benzylhydrazides containing different substituents in the para position. [...]
2022 - 10.1016/j.jinorgbio.2022.111932
Journal of Inorganic Biochemistry, Vol. 235 (Oct. 2022) , art. 111932
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11 p, 5.5 MB |
Implications of protein interaction in the speciation of potential VIVO-pyridinone drugs
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Ferraro, Giarita (Università degli Studi di Napoli Federico II. Dipartimento di Scienze Chimiche) ;
Paolillo, Maddalena (Università degli Studi di Napoli Federico II. Dipartimento di Scienze Chimiche) ;
Sciortino, Giuseppe (Institut d'Investigacions Químiques de Catalunya) ;
Pisanu, Federico (Universitàdi Sassari. Dipartimento di Medicina, Chirurgia e Farmacia) ;
Garribba, Eugenio (Università di Sassari. Dipartimento di Medicina, Chirurgia e Farmacia) ;
Merlino, Antonello (Università degli Studi di Napoli Federico II. Dipartimento di Scienze Chimiche)
Vanadium complexes (VCs) are promising agents for the treatment, among others, of diabetes and cancer. The development of vanadium-based drugs is mainly limited by a scarce knowledge of the active species in the target organs, which is often determined by the interaction of VCs with biological macromolecules like proteins. [...]
2023 - 10.1021/acs.inorgchem.3c01041
Inorganic chemistry, Vol. 62, issue 21 (May 2023) , p. 8407-8417
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4.
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10 p, 5.0 MB |
Multiple and Variable Binding of Pharmacologically Active Bis(maltolato)oxidovanadium(IV) to Lysozyme
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Ferraro, Giarita (Università degli Studi di Napoli Federico II. Dipartimento di Scienze Chimiche) ;
Paolillo, Maddalena (Università degli Studi di Napoli Federico II. Dipartimento di Scienze Chimiche) ;
Sciortino, Giuseppe (Institut d'Investigacions Químiques de Catalunya) ;
Garribba, Eugenio (Università di Sassari. Dipartimento di Medicina, Chirurgia e Farmacia) ;
Merlino, Antonello (Università degli Studi di Napoli Federico II. Dipartimento di Scienze Chimiche)
The interaction with proteins of metal-based drugs plays a crucial role in their transport, mechanism, and activity. For an active MLn complex, where L is the organic carrier, various binding modes (covalent and non-covalent, single or multiple) may occur and several metal moieties (M, ML, ML2, etc. [...]
2022 - 10.1021/acs.inorgchem.2c02690
Inorganic chemistry, Vol. 61, Issue 41 (October 2022) , p. 16458-16467
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5.
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Oxidovanadium(IV) sulfate catalyses light-driven C-N bond formation
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Gaspa, Silvia (Università di Sassari. Dipartimento di Scienze Chimiche) ;
Sciortino, Giuseppe (Institut d'Investigacions Químiques de Catalunya) ;
Porcheddu, Andrea (Università degli Studi di Cagliari) ;
Dell'Osa, Chiara (Università di Sassari. Dipartimento di Scienze Chimiche) ;
Satta, Giuseppe (Università di Sassari. Dipartimento di Scienze Chimiche) ;
Azzena, Ugo (Università di Sassari. Dipartimento di Scienze Chimiche) ;
Pisano, Luisa (Università di Sassari. Dipartimento di Scienze Chimiche) ;
Carraro, Massimo (Università di Sassari. Dipartimento di Scienze Chimiche) ;
Sanna, Daniele (Istituto CNR di Chimica Biomolecolare) ;
Garribba, Eugenio (Università di Sassari. Dipartimento di Medicina, Chirurgia e Farmacia) ;
Maseras Cuní, Feliu (Institut d'Investigacions Químiques de Catalunya) ;
De Luca, Lidia (Università di Sassari. Dipartimento di Scienze Chimiche)
Oxidovanadium(IV) sulfate, VIVOSO4, is shown to catalyze efficiently the amidation of the C-H bond of aldehydes by N-chloramine derivatives for the selective synthesis of amides. The catalytic process is driven by visible light irradiation at room temperature, and the reaction is carried out in ethyl acetate, a green and bio-based solvent. [...]
2023 - 10.1016/j.mcat.2023.113054
Molecular Catalysis, Vol. 541 (April 2023) , art. 113054
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47 p, 1.4 MB |
VIVO complexes with antibacterial quinolone ligands and their interaction with serum proteins
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Sanna, Daniele (Istituto CNR di Chimica Biomolecolare) ;
Ugone, Valeria (Istituto CNR di Chimica Biomolecolare) ;
Sciortino, Giuseppe (Universitat Autònoma de Barcelona. Departament de Química) ;
Buglyó, Péter (University of Debrecen. Department of Inorganic and Analytical Chemistry) ;
Bihari, Zsolt (University of Debrecen. Department of Inorganic and Analytical Chemistry) ;
Parajdi-Losonczi, Péter László (University of Debrecen. Department of Inorganic and Analytical Chemistry) ;
Garribba, Eugenio (Università di Sassari. Dipartimento di Medicina, Chirurgia e Farmacia)
Quinolone derivatives are among the most commonly prescribed antibacterials in the world and could also attract interest as organic ligands in the design of metal complexes with potential pharmacological activity. [...]
2018 - 10.1039/c7dt04216g
Dalton transactions, Vol. 47, Issue 7 (February 2018) , p. 2164-2182
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13 p, 1.1 MB |
Interaction of VIVO-8-hydroxyquinoline species with RNase A : the effect of metal ligands in the protein adduct stabilization
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Ferraro, Giarita (Università degli Studi di Napoli Federico II. Dipartimento di Scienze Chimiche) ;
Vitale, Luigi (Università degli Studi di Napoli Federico II. Dipartimento di Scienze Chimiche) ;
Sciortino, Giuseppe (Institut d'Investigacions Químiques de Catalunya) ;
Pisanu, Federico (Università di Sassari) ;
Garribba, Eugenio (Università di Sassari. Dipartimento di Medicina, Chirurgia e Farmacia) ;
Merlino, Antonello (Università degli Studi di Napoli Federico II. Dipartimento di Scienze Chimiche)
Herein, we studied the interaction of bovine pancreatic ribonuclease (RNase A) with [VIVO(8-HQ)2] - a promising antitrypanosomal, antituberculosis, and antitumor vanadium complex (VC) formed by 8-hydroxyquinolinato (8-HQ), reaching IC50 values lower than cisplatin in HCT116 and A2780 cancer lines (0. [...]
2023 - 10.1039/d3qi01023f
Inorganic Chemistry Frontiers, Vol. 10, Issue 17 (September 2023) , p. 5186-5198
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22 p, 10.5 MB |
A Series of Non-Oxido VIVComplexes of Dibasic ONS Donor Ligands : Solution Stability, Chemical Transformations, Protein Interactions, and Antiproliferative Activity
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Banerjee, Atanu (National Institute of Technology Rourkela) ;
Patra, Sushree Aradhana (National Institute of Technology Rourkela) ;
Sahu, Gurunath (National Institute of Technology Rourkela) ;
Sciortino, Giuseppe (Institut d'Investigacions Químiques de Catalunya) ;
Pisanu, Federico (Università di Sassari) ;
Garribba, Eugenio (Università di Sassari. Dipartimento di Medicina, Chirurgia e Farmacia) ;
Carvalho, M. Fernanda N.N. (Universidade de Lisboa) ;
Correia, Isabel (Universidade de Lisboa) ;
Costa Pessoa, João (Universidade de Lisboa) ;
Reuter, Hans (Osnabrück University) ;
Dinda, Rupam (National Institute of Technology Rourkela)
A series of mononuclear non-oxido vanadium(IV) complexes, [VIV(L1-4)2] (1-4), featuring tridentate bi-negative ONS chelating S-alkyl/aryl-substituted dithiocarbazate ligands H2L1-4, are reported. All the synthesized non-oxido VIVcompounds are characterized by elemental analysis, spectroscopy (IR, UV-vis, and EPR), ESI-MS, as well as electrochemical techniques (cyclic voltammetry). [...]
2023 - 10.1021/acs.inorgchem.3c00753
Inorganic chemistry, Vol. 62, Issue 20 (May 2023) , p. 7932-7953
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9.
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17 p, 2.1 MB |
Promising anticancer agents based on 8-hydroxyquinoline hydrazone copper(II) complexes
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Ribeiro, Nádia (Universidade de Lisboa) ;
Bulut, Ipek (Koç University) ;
Sergi, Baris (Koç University) ;
Pósa, Vivien (University of Szeged) ;
Spengler, Gabriella (University of Szeged) ;
Sciortino, Giuseppe (Institut d'Investigacions Químiques de Catalunya) ;
André, Vânia (Universidade de Lisboa) ;
Ferreira, Liliana P. (Universidade de Lisboa) ;
Biver, Tarita (Università degli Studi di Pisa) ;
Ugone, Valeria (Istituto CNR di Chimica Biomolecolare) ;
Garribba, Eugenio (Università di Sassari. Dipartimento di Medicina, Chirurgia e Farmacia) ;
Costa Pessoa, João (Universidade de Lisboa) ;
Enyedy, Éva A. (University of Szeged) ;
Acilan, Ceyda (Koç University) ;
Correia, Isabel (Universidade de Lisboa)
We report the synthesis and characterization of a group of benzoylhydrazones (Ln) derived from 2-carbaldehyde-8-hydroxyquinoline and benzylhydrazides containing distinct para substituents (R = H, Cl, F, CH3, OCH3, OH and NH2, for L1-7, respectively; in L8 isonicotinohydrazide was used instead of benzylhydrazide). [...]
2023 - 10.3389/fchem.2023.1106349
Frontiers in chemistry, Vol. 11 (March 2023) , art. 1106349
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22 p, 904.1 KB |
Binding of VIVO2+, VIVOL, VIVOL2 and VVO2L Moieties to Proteins : X-ray/Theoretical Characterization and Biological Implications
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Santos, Marino F.A. (Universidade NOVA de Lisboa) ;
Sciortino, Giuseppe (Institut d'Investigacions Químiques de Catalunya) ;
Correia, Isabel (Universidade de Lisboa) ;
Fernandes, Andreia C.P. (Universidade NOVA de Lisboa) ;
Santos-Silva, Teresa (Universidade NOVA de Lisboa) ;
Pisanu, Federico (Università di Sassari) ;
Garribba, Eugenio (Università di Sassari. Dipartimento di Medicina, Chirurgia e Farmacia) ;
Costa Pessoa, João (Universidade de Lisboa)
Vanadium compounds have frequently been proposed as therapeutics, but their application has been hampered by the lack of information on the different V-containing species that may form and how these interact with blood and cell proteins, and with enzymes. [...]
2022 - 10.1002/chem.202200105
Chemistry, Vol. 28, Issue 40 (July 2022) , art. e202200105
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