Results overview: Found 9 records in 0.01 seconds.
Articles, 9 records found
Articles 9 records found  
1.
14 p, 12.2 MB Local administration of porcine immunomodulatory, chemotactic and angiogenic extracellular vesicles using engineered cardiac scaffolds for myocardial infarction / Monguió-Tortajada, Marta (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Prat-Vidal, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Moron-Font, Miriam (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Clos-Sansalvador, Marta (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Calle Arias, Alexandra (Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA). Departamento de Reproducción Animal) ; Gastelurrutia, Paloma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Cserkóová, Adriana (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Morancho, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Ramírez de Paz, Miguel Ángel (Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA). Departamento de Reproducción Animal) ; Rosell Novel, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Bayés-Genís, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina) ; Gálvez-Montón, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Borràs, Francesc E. (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Rudilla, F (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
The administration of extracellular vesicles (EV) from mesenchymal stromal cells (MSC) is a promising cell-free nanotherapy for tissue repair after myocardial infarction (MI). However, the optimal EV delivery strategy remains undetermined. [...]
2021 - 10.1016/j.bioactmat.2021.02.026
Bioactive Materials, Vol. 6 (march 2021) , p. 3314-3327  
2.
10 p, 1.8 MB Transitioning From Preclinical Evidence to Advanced Therapy Medicinal Product : A Spanish Experience / Gastelurrutia, Paloma (Institut Germans Trias i Pujol) ; Prat-Vidal, Cristina (Institut Germans Trias i Pujol) ; Vives Armengol, Joaquim (Universitat Autònoma de Barcelona. Departament de Medicina) ; Coll, Ruth (Banc de Sang i Teixits. Servei de Teràpia Cel·lular) ; Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Gálvez-Montón, Carolina (Institut Germans Trias i Pujol)
A systematic and ordered product development program, in compliance with current quality and regulatory standards, increases the likelihood of yielding a successful advanced therapy medicinal product (ATMP) for clinical use as safe and effective therapy. [...]
2021 - 10.3389/fcvm.2021.604434
Frontiers in Cardiovascular Medicine, Vol. 8 (february 2021)  
3.
11 p, 2.3 MB First-in-human PeriCord cardiac bioimplant : scalability and GMP manufacturing of an allogeneic engineered tissue graft / Prat-Vidal, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Rodríguez-Gómez, Luciano (Cell Therapy Service, Banc de Sang i Teixits, Edifici Dr. Frederic Duran i Jordà) ; Aylagas, Miriam (Hospital Universitari Vall d'Hebron) ; Nieto-Nicolau, Nuria (Banc de Sang i Teixits (Barcelona, Catalunya)) ; Gastelurrutia, Paloma (Institut d'Investigació Biomèdica de Bellvitge) ; Agustí, Elba (Banc de Sang i Teixits (Barcelona, Catalunya)) ; Gálvez-Montón, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Jorba, Ignasi (Institut de Bioenginyeria de Catalunya) ; Teis, Albert (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Monguió-Tortajada, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Rudilla, F (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ; Vives Armengol, Joaquim (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Torrents-Zapata, Silvia (Banc de Sang i Teixits (Barcelona, Catalunya)) ; Coca, María Isabel (Banc de Sang i Teixits (Barcelona, Catalunya)) ; Reales, Laura (Banc de Sang i Teixits (Barcelona, Catalunya)) ; Cámara-Rosell, María Luisa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Cediel, Germán (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Farré, Ramon (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Coll, Ruth (Research and Education. Banc de Sang i Teixits) ; Navajas, Daniel (Institut de Bioenginyeria de Catalunya) ; Vilarrodona, Anna (Banc de Sang i Teixits (Barcelona, Catalunya)) ; García López, Joan (Banc de Sang i Teixits (Barcelona, Catalunya)) ; Muñoz-Guijosa, Christian (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Querol, Sergi (Hospital Universitari Vall d'Hebron) ; Bayés-Genís, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina) ; Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol ; VHIR Vall d'Hebron Institut de Recerca ; Universitat Autònoma de Barcelona. Departament de Medicina
Small cardiac tissue engineering constructs show promise for limiting post-infarct sequelae in animal models. This study sought to scale-up a 2-cm 2 preclinical construct into a human-size advanced therapy medicinal product (ATMP; PeriCord), and to test it in a first-in-human implantation. [...]
2020 - 10.1016/j.ebiom.2020.102729
EBioMedicine, Vol. 54 (april 2020)  
4.
8 p, 940.6 KB Neprilysin inhibition, endorphin dynamics, and early symptomatic improvement in heart failure : a pilot study / Revuelta-López, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Núñez, Julio (Hospital Clínic Universitari (València)) ; Gastelurrutia, Paloma (Institut Germans Trias i Pujol) ; Januzzi, James L. (Massachusetts General Hospital and Cardiometabolic Trials, Baim Institute for Clinical Research) ; Ibrahim, Nasrien E. (Massachusetts General Hospital and Cardiometabolic Trials, Baim Institute for Clinical Research) ; Emdin, Michele (Scuola Superiore Sant'Anna, Fondazione Toscana Gabriele Monasterio) ; VanKimmenade, Roland (Radboud University Medical Centre) ; Pascual-Figal, Domingo (Universidad de Murcia) ; Núñez, Eduardo (Hospital Clínic Universitari (València)) ; Gommans, Frank (Radboud University Medical Centre) ; Lupón, Josep (Universitat Autònoma de Barcelona. Departament de Medicina) ; Bayés-Genís, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina)
Sacubitril/valsartan is a first-in-class angiotensin receptor-neprilysin inhibitor developed for the treatment of heart failure with reduced ejection fraction. Its benefits are achieved through the inhibition of neprilysin (NEP) and the specific blockade of the angiotensin receptor AT1. [...]
2020 - 10.1002/ehf2.12607
ESC Heart Failure, Vol. 7 (february 2020) , p. 559-566  
5.
8 p, 164.5 KB Determination of HLA-A, -B, -C, -DRB1 and -DQB1 allele and haplotype frequencies in heart failure patients / Rudilla, Francesc (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Gastelurrutia, Paloma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Enrich, E. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Campos, E. (Histocompatibility and Immunogenetics Laboratory. Blood and Tissue Bank) ; Lupón, Josep (Universitat Autònoma de Barcelona. Departament de Medicina) ; Santiago Vacas, Evelyn (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Querol, S. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Aims: Cell therapy can be used to repair functionally impaired organs and tissues in humans. Although autologous cells have an immunological advantage, it is difficult to obtain high cell numbers for therapy. [...]
2019 - 10.1002/ehf2.12406
ESC Heart Failure, Vol. 6 Núm. 2 (april 2019) , p. 388-395  
6.
5 p, 161.7 KB Potential role for clinical calibration to increase engagement with and application of home telemonitoring: a report from the HeartCycle programme / Gastelurrutia, Paloma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Lupón, Josep (Universitat Autònoma de Barcelona. Departament de Medicina) ; Domingo, Mar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Stut, Wim (Philips Research, Eindhoven) ; Dovancescu, Silviu (Philips Research, Eindhoven) ; Cleland, John (National Heart and Lung Institute, Harefield Hospital, Imperial College) ; Frankenstein, Lutz (Heidelberg University Hospital (Alemanya)) ; Bayes Genis, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; HeartCycle Programme Investigators
Aims: There is a need for alternative strategies that might avoid recurrent admissions in patients with heart failure. home telemonitoring (HTM) to monitor patient's symptoms from a distance may be useful. [...]
2017 - 10.1002/ehf2.12104
ESC Heart Failure, Núm. 4 (2017) , p. 66  
7.
10 p, 723.5 KB Extracellular vesicles do not contribute to higher circulating levels of soluble 1 in idiopathic dilated cardiomyopathy / Rudilla, F (Institut Germans Trias i Pujol) ; Gálvez-Montón, Carolina (Institut Germans Trias i Pujol) ; de Gonzalo Calvo, David (Institut d'Investigació Biomèdica Sant Pau) ; Valero, Ana Gámez (Institut Germans Trias i Pujol) ; Gastelurrutia, Paloma (Institut Germans Trias i Pujol) ; Revuelta López, Elena (Institut Germans Trias i Pujol) ; Prat Vidal, Cristina (Institut Germans Trias i Pujol) ; Soler Botija, Carolina (Institut Germans Trias i Pujol) ; Llucià Valldeperas, Aida (Institut Germans Trias i Pujol) ; Perea Gil, Isaac (Institut Germans Trias i Pujol) ; Iborra Egea, Oriol (Institut Germans Trias i Pujol) ; Borràs, Francesc E (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Lupón, Josep (Universitat Autònoma de Barcelona. Departament de Medicina) ; Llorente Cortés, Vicenta (Institut d'Investigació Biomèdica Sant Pau) ; Bayes Genis, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina) ; Universitat Autònoma de Barcelona
Idiopathic dilated cardiomyopathy () is a frequent cause of heart transplantation. Potentially valuable blood markers are being sought, and low-density lipoprotein receptor-related protein 1 (1) has been linked to the underlying molecular basis of the disease. [...]
2017 - 10.1111/jcmm.13211
Journal of Cellular and Molecular Medicine, Vol. 21 (may 2017) , p. 3000-3009  
8.
7 p, 970.6 KB First-in-man Safety and Efficacy of the Adipose Graft Transposition Procedure (AGTP) in Patients With a Myocardial Scar / Bayés-Genís, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina) ; Gastelurrutia, Paloma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Cámara, Maria-Luisa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Teis, Albert (Clínica Creu Blanca, Barcelona, Spain) ; Lupón, Josep (Universitat Autònoma de Barcelona. Departament de Medicina) ; Llibre, Cinta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Zamora, Elisabet (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Alomar, Xavier (Clínica Creu Blanca, Barcelona, Spain) ; Ruyra, Xavier (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Rudilla, F (Centro de Medicina Regenerativa de Barcelona) ; Revilla, Ana (ICICORELAB, Clinic University Hospital, Valladolid, Spain) ; San Román, José Alberto (ICICORELAB, Clinic University Hospital, Valladolid, Spain) ; Gálvez-Montón, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
The present study evaluates the safety and efficacy of the Adipose Graft Transposition Procedure (AGTP) as a biological regenerative innovation for patients with a chronic myocardial scar. This prospective, randomized single-center controlled study included 10 patients with established chronic transmural myocardial scars. [...]
2016 - 10.1016/j.ebiom.2016.03.027
EBioMedicine, Vol. 7 (april 2016) , p. 248-254  
9.
8 p, 264.7 KB Limited Value of Cystatin-C over Estimated Glomerular Filtration Rate for Heart Failure Risk Stratification / Zamora, Elisabet (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Lupón, Josep (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; de Antonio Ferrer, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Vila, Joan (Institut Hospital del Mar d'Investigacions Mèdiques) ; Galán, Amparo (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Gastelurrutia, Paloma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Urrutia de Diego, Agustín (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Bayés Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Background: to compare the prognostic value of estimated glomerular filtration rate, cystatin-C, an alternative renal biomarker, and their combination, in an outpatient population with heart failure. [...]
2012 - 10.1371/journal.pone.0051234
PloS one, Vol. 7 Issue 12 (December 2012) , p. e51234  

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