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1.
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7 p, 2.8 MB |
Paper-Based Analytical Devices for Accurate Assessment of Transferrin Saturation in Diagnosed Clinical Samples from Ischemic Stroke Patients
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Dortez, Silvia (Universidad de Alcalá) ;
De Gregorio-Rocasolano, Nuria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Millán, Mònica (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gasull Dalmau, Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Crevillen, Agustín G. (Universidad Nacional de Educacion a Distancia (UNED)) ;
Escarpa, Alberto (Universidad de Alcalá) ;
Universitat Autònoma de Barcelona
For the first time, a paper-based analytical device (PAD) was developed for the assessment of transferrin saturation (TSAT), which is defined as the ratio between iron bound to transferrin (Tf) and the total iron-binding capacity (TIBC) of Tf. [...]
2023 -  10.1021/acs.analchem.3c01982
Analytical chemistry, Vol. 95 (07 2023) , p. 12391-12397
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2.
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18 p, 4.0 MB |
Targeting Pro-Oxidant Iron with Exogenously Administered Apotransferrin Provides Benefits Associated with Changes in Crucial Cellular Iron Gate Protein TfR in a Model of Intracerebral Hemorrhagic Stroke in Mice
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García Serran, Alexia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ordoño, Jesus (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
De Gregorio-Rocasolano, Nuria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Melià Sorolla, Marc (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Odendaal, Karla (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martí-Sistac, Octavi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gasull Dalmau, Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
We have previously demonstrated that the post-stroke administration of iron-free transferrin (apotransferrin, ATf) is beneficial in different models of ischemic stroke (IS) through the inhibition of the neuronal uptake of pro-oxidant iron. [...]
2023 - 10.3390/antiox12111945
Antioxidants, Vol. 12 Núm. 11 (October 2023)
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3.
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12 p, 1.2 MB |
Evaluation and Characterization of Post-Stroke Lung Damage in a Murine Model of Cerebral Ischemia
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Faura, Júlia (Hospital Universitari Vall d'Hebron) ;
Ramiro, Laura (Hospital Universitari Vall d'Hebron) ;
Simats Oriol, Alba (Hospital Universitari Vall d'Hebron) ;
Ma, Feifei (Hospital Universitari Vall d'Hebron) ;
Penalba, Anna (Hospital Universitari Vall d'Hebron) ;
Gasull Dalmau, Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rosell Novel, Anna (Hospital Universitari Vall d'Hebron) ;
Montaner, Joan (Hospital Universitari Vall d'Hebron) ;
Bustamante, Alejandro (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
After stroke and other brain injuries, there is a high incidence of respiratory complications such as pneumonia or acute lung injury. The molecular mechanisms that drive the brain-lung interaction post-stroke have not yet been elucidated. [...]
2022 - 10.3390/ijms23158093
International journal of molecular sciences, Vol. 23 (july 2022)
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4.
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16 p, 7.7 MB |
Establishment of a reproducible and minimally invasive ischemic stroke model in swine
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Castaño, Carlos (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Melià Sorolla, Marc (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
García Serran, Alexia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
De Gregorio-Rocasolano, Nuria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
García-Sort, Maria Rosa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Hernández-Pérez, María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Valls-Carbó, Adrián (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pino, Osvaldo (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Grífols, Jordi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Iruela-Sánchez, Alba (Canon Medical Systems) ;
Palomar-García, Alicia (Canon Medical Systems) ;
Puig, Josep (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martí-Sistac, Octavi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Dávalos, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gasull Dalmau, Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
The need for advances in the management/treatment options for ischemic stroke patients requires that upcoming preclinical research uses animals with more human-like brain characteristics. The porcine brain is considered appropriate, although the presence of the rete mirabile (RM) prevents direct catheterization of the intracranial arteries to produce focal cerebral ischemia. [...]
2023 - 10.1172/jci.insight.163398
JCI Insight, Vol. 8 (april 2023)
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5.
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15 p, 1.7 MB |
Article targeting pro-oxidant iron with deferoxamine as a treatment for ischemic stroke : safety and optimal dose selection in a randomized clinical trial
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Millán, Mónica (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
De Gregorio-Rocasolano, Nuria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
de la Ossa Pérez, Natàlia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Reverté, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Costa, Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Giner, Pilar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Silva, Yolanda (Hospital Universitari de Girona Doctor Josep Trueta) ;
Sobrino, Tomás (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
Rodríguez-Yáñez, Manuel (Hospital Clínico Universitario. Departamento de Neurología) ;
Nombela, Florentino (Hospital Universitario de la Princesa (Madrid)) ;
Campos, Francisco (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
Serena, Joaquín (Hospital Universitari de Girona Doctor Josep Trueta) ;
Vivancos, José (Hospital Universitario de la Princesa (Madrid)) ;
Martí-Sistac, Octavi (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Cortés, Jordi (Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa) ;
Dávalos, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gasull Dalmau, Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
A role of iron as a target to prevent stroke-induced neurodegeneration has been recently revisited due to new evidence showing that ferroptosis inhibitors are protective in experimental ischemic stroke and might be therapeutic in other neurodegenerative brain pathologies. [...]
2021 - 10.3390/antiox10081270
Antioxidants, Vol. 10, p. 1270
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6.
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21 p, 4.5 MB |
Comparative Proteomics Unveils LRRFIP1 as a New Player in the DAPK1 Interactome of Neurons Exposed to Oxygen and Glucose Deprivation
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De Gregorio-Rocasolano, Nuria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Guirao, Verónica (Institut Germans Trias i Pujol) ;
Ponce, Jovita (Institut Germans Trias i Pujol) ;
Melià Sorolla, Marc (Institut Germans Trias i Pujol) ;
Aliena-Valero, Alicia (Universitat de València. Unidad Mitxa de Investigación Cerebrovascular) ;
García Serran, Alexia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Salom, Juan B. (Universitat de València. Unidad Mitxa de Investigación Cerebrovascular) ;
Dávalos, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martí-Sistac, Octavi (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Gasull Dalmau, Teresa (Institut Germans Trias i Pujol)
Death-associated protein kinase 1 (DAPK1) is a pleiotropic hub of a number of networked distributed intracellular processes. Among them, DAPK1 is known to interact with the excitotoxicity driver NMDA receptor (NMDAR), and in sudden pathophysiological conditions of the brain, e. [...]
2020 - 10.3390/antiox9121202
Antioxidants, Vol. 9 Núm. 12 (2020) , p. 1202
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7.
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30 p, 861.2 KB |
Relevance of Porcine Stroke Models to Bridge the Gap from Pre-Clinical Findings to Clinical Implementation
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Melià Sorolla, Marc (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
De Gregorio-Rocasolano, Nuria (Institut Germans Trias i Pujol) ;
Rodríguez-Esparragoza, Luis (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Dávalos, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martí-Sistac, Octavi (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Gasull Dalmau, Teresa (Institut Germans Trias i Pujol) ;
Castaño, Carlos (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
In the search of animal stroke models providing translational advantages for biomedical research, pigs are large mammals with interesting brain characteristics and wide social acceptance. Compared to rodents, pigs have human-like highly gyrencephalic brains. [...]
2020 - 10.3390/ijms21186568
International journal of molecular sciences, Vol. 21 Núm. 18 (2020) , p. 6568
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8.
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17 p, 2.0 MB |
Deciphering the iron side of stroke : Neurodegeneration at the crossroads between iron dyshomeostasis, excitotoxicity, and ferroptosis
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De Gregorio-Rocasolano, Nuria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martí-Sistac, O. (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Gasull Dalmau, Teresa (Institut Germans Trias i Pujol)
In general, iron represents a double-edged sword in metabolism in most tissues, especially in the brain. Although the high metabolic demands of brain cells require iron as a redox-active metal for ATP-producing enzymes, the brain is highly vulnerable to the devastating consequences of excessive iron-induced oxidative stress and, as recently found, to ferroptosis as well. [...]
2019 - 10.3389/fnins.2019.00085
Frontiers in Neuroscience, Vol. 13 Núm. FEB (2019) , p. 85
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9.
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16 p, 2.3 MB |
Iron-loaded transferrin (Tf) is detrimental whereas iron-free Tf confers protection against brain ischemia by modifying blood Tf saturation and subsequent neuronal damage
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Gregorio-Rocasolano Barbany, Núria de (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martí Sistac, Octavi (Universitat Autònoma de Barcelona) ;
Ponce, Jovita (Institut Germans Trias i Pujol) ;
Castelló Ruiz, María (Instituto de Investigación Sanitaria La Fe) ;
Millán Torné, Mònica (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Guirao, Verónica (Institut Germans Trias i Pujol) ;
García Yébenes, Isaac (Universidad Complutense de Madrid. Departamento de Farmacología) ;
Salom, Juan B. (Instituto de Investigación Sanitaria La Fe) ;
Ramos Cabrer, Pedro (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
Alborch, Enrique (Instituto de Investigación Sanitaria La Fe) ;
Lizasoain, Ignacio (Universidad Complutense de Madrid. Departamento de Farmacología) ;
Castillo, José (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
Dávalos, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gasull Dalmau, Teresa (Institut Germans Trias i Pujol)
Despite transferrin being the main circulating carrier of iron in body fluids, and iron overload conditions being known to worsen stroke outcome through reactive oxygen species (ROS)-induced damage, the contribution of blood transferrin saturation (TSAT) to stroke brain damage is unknown. [...]
2018 - 10.1016/j.redox.2017.11.026
Redox biology, Vol. 15 (May 2018) , p. 143-158
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