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17 p, 2.3 MB H3K79me2/3 controls enhancer-promoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in MLL-AF4 leukemia cells / Godfrey, L. (University of Oxford. Department of Medicine) ; Crump, N. T. (University of Oxford. Department of Medicine) ; O'Byrne, Sorcha (Department of Paediatrics. University of Oxford) ; Lau, I. J. (University of Oxford. Department of Medicine) ; Rice, S. (University of Oxford. Department of Medicine) ; Harman, J. R. (University of Oxford. Department of Medicine) ; Jackson, T. (Department of Paediatrics. University of Oxford) ; Elliott, N. (Department of Paediatrics. University of Oxford) ; Buck, G. (Department of Paediatrics. University of Oxford) ; Connor, C. (Great Ormond Street Hospital for Children (Londres)) ; Thorne, R. (University of Oxford. Department of Medicine) ; Knapp, D. J. H. F. (MRC Weatherall Institute of Molecular Medicine. Radcliffe Department of Medicine. University of Oxford) ; Heidenreich, O. (Newcastle University. Wolfson Childhood Cancer Research Centre) ; Vyas, P. (Department of Haematology. Oxford University Hospitals NHS Foundation Trust) ; Menéndez Bujan, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Inglott, S. (Great Ormond Street Hospital for Children (Londres)) ; Ancliff, P. (Great Ormond Street Hospital for Children (Londres)) ; Geng, H. (Department of Laboratory Medicine. University of California. San Francisco) ; Roberts, I. (Department of Paediatrics. University of Oxford) ; Roy, A. (Department of Paediatrics. University of Oxford) ; Milne, T. A. (University of Oxford. Department of Medicine) ; Universitat Autònoma de Barcelona
MLL gene rearrangements (MLLr) are a common cause of aggressive, incurable acute lymphoblastic leukemias (ALL) in infants and children, most of which originate in utero. The most common MLLr produces an MLL-AF4 fusion protein. [...]
2021 - 10.1038/s41375-020-0808-y
Leukemia, Vol. 35 Núm. 1 (january 2021) , p. 90-106  
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