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12 p, 831.3 KB |
Preoperative CA125 Significantly Improves Risk Stratification in High-Grade Endometrial Cancer
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Lombaers, Marike S. (Radboud Institute of Health Sciences (Holanda)) ;
Cornel, Karlijn M. C. (Department of Obstetrics and Gynecology, University of Toronto) ;
Visser, Nicole C. M. (Department of Pathology, Eurofins PAMM (Països Baixos)) ;
Bulten, Johan (Radboud University Medical Center (Holanda)) ;
Küsters-Vandevelde, Heidi V. N. (Department of Pathology, Canisius-Wilhelmina Hospital (Països Baixos)) ;
Amant, Frederic (The Netherlands Cancer Institute (Països Baixos)) ;
Boll, Dorry (Department of Gynecology, Catharina Hospital (Països Baixos)) ;
Bronsert, Peter (University Medical Center) ;
Colás Ortega, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Geomini, Peggy M. A. J. (Department of Obstetrics and Gynecology, Maxima Medical Centre (Països Baixos)) ;
Gil-Moreno, Antonio 1965- (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
van Hamont, Dennis (Department of Obstetrics and Gynecology, Amphia Hospital (Països Baixos)) ;
Huvila, Jutta (Department of Pathology, University of Turku (Països Baixos)) ;
Krakstad, Camilla (Department of Clinical Science, University of Bergen) ;
Kraayenbrink, Arjan A. (Department of Obstetrics and Gynaecology, Rijnstate Hospital (Països Baixos)) ;
Koskas, Martin (Department of Obstetrics and Gynecology, Bichat-Claude Bernard Hospital (França)) ;
Mancebo, Gemma (Hospital del Mar (Barcelona, Catalunya)) ;
Matías-Guiu, Xavier (Department of Pathology and Molecular Genetics and Research Laboratory, Hospital Universitari Arnau de Vilanova) ;
Ngo, Huy (Department of Obstetrics and Gynecology, Elkerliek Hospital (Països Baixos)) ;
Pijlman, Brenda M. (Department of Obstetrics and Gynecology, Jeroen Bosch Hospital, 5223 GZ 's-Hertogenbosch (Països Baixos)) ;
Vos, Maria Caroline (Department of Obstetrics and Gynecology, Elisabeth-TweeSteden Hospital (Països Baixos)) ;
Weinberger, Vit (Department of Gynecology and Obstetrics, University Hospital Brno, Faculty of Medicine, Masaryk University (República Txeca)) ;
Snijders, Marc P. L. M. (Department of Obstetrics and Gynecology, Canisius-Wilhelmina Hospital (Països Baixos)) ;
van Koeverden, Sebastiaan W. (Department of Radiology and Nuclear Medicine, Radboud University Medical Center (Països Baixos)) ;
Haldorsen, Ingfrid S. (Mohn Medical Imaging and Visualization Centre, Department of Radiology, Haukeland University Hospital, 5021 Bergen, Norway) ;
Reijnen, Casper (Department of Radiation Oncology, Radboud University Medical Center (Països Baixos)) ;
Pijnenborg, Johanna M. A. (Radboud Institute of Health Sciences (Països Baixos)) ;
Universitat Autònoma de Barcelona
Patients with high-grade uterine cancer (UC) have a risk of around 20% of the cancer spreading to the lymph nodes, while this is only around 10% in patients with low-grade uterine cancer. CA125 is a marker that can be detected in blood and is associated with increased tumor spread. [...]
2023 -  10.3390/cancers15092605
Cancers, Vol. 15 (may 2023)
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2.
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18 p, 3.7 MB |
Neoadjuvant Chemotherapy plus Interval Cytoreductive Surgery with or without Hyperthermic Intraperitoneal Chemotherapy (NIHIPEC) in the Treatment of Advanced Ovarian Cancer : A Multicentric Propensity Score Study
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Llueca, Antoni (Department of Medicine, University Jaume I) ;
Ibañez, Maria Victoria (Department of Mathematics, University Jaume I) ;
Cascales, Pedro (Hospital Universitario Virgen de la Arrixaca (Múrcia)) ;
Gil-Moreno, Antonio 1965- (Vall d'Hebron Institut d'Oncologia) ;
Bebia, Vicente (Vall d'Hebron Institut d'Oncologia) ;
Ponce, Jordi (Department of Gynecology, University Hospital of Bellvitge) ;
Fernández-González, Sergi (Department of Gynecology, University Hospital of Bellvitge, 08907 Barcelona, Spain; (J.P.); (S.F.)) ;
Arjona-Sanchez, Alvaro (University Hospital Reina Sofia) ;
Muruzabal, Juan Carlos (Department of Gynecologic Oncology, Complejo Hospitalario de Navarra) ;
Veiga, Nadia (Department of Gynecologic Oncology, Complejo Hospitalario de Navarra) ;
Díaz-Feijoo, Berta (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Celada, Cristina (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Gilabert-Estelles, Juan (Department of Obstetrics and Gynecology, University General Hospital of Valencia) ;
Aghababyan, Cristina (Department of Obstetrics and Gynecology, University General Hospital of Valencia) ;
Lacueva, Javier (Department of General Surgery, University General Hospital of Elche) ;
Calero, Alicia (Department of General Surgery, University General Hospital of Elche) ;
Segura-Sampedro, Juan José (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Maiocchi, Karina (Department of General Surgery, University General Hospital of Castellon) ;
Llorca, Sara (Department of General Surgery, University General Hospital of Castellon) ;
Villarin, Alvaro (Department of General Surgery, University General Hospital of Castellon) ;
Climent, Maria Teresa (Department of Medicine, University Jaume I) ;
Delgado, Katty (Department of Medicine, University Jaume I) ;
Serra Rubert, Anna (Department of Medicine, University Jaume I) ;
Gomez-Quiles, Luis (Department of General Surgery, University General Hospital of Castellon) ;
Llueca, Maria (Hospital Universitari Joan XXIII de Tarragona) ;
Universitat Autònoma de Barcelona
Advanced ovarian cancer (Stages III-IV) continues to be one of the gynecological tumors with the highest mortality. Standard treatment consists of debulking surgery and subsequent adjuvant chemotherapy. [...]
2023 - 10.3390/cancers15174271
Cancers, Vol. 15 (august 2023)
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3.
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15 p, 1.9 MB |
In silico Approach for Validating and Unveiling New Applications for Prognostic Biomarkers of Endometrial Cancer
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Coll de la Rubia, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martinez-Garcia, Elena (Luxembourg Institute of Health) ;
Dittmar, Gunnar (Luxembourg Institute of Health) ;
Nazarov, Petr V. (Luxembourg Institute of Health) ;
Bebia, Vicente (Hospital Universitari Vall d'Hebron) ;
Cabrera Díaz, Silvia (Hospital Universitari Vall d'Hebron) ;
Gil-Moreno, Antonio 1965- (Hospital Universitari Vall d'Hebron) ;
Colás Ortega, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Endometrial cancer (EC) mortality is directly associated with the presence of poor prognostic factors. Molecular prognostic factors have been identified, but none are used in clinical practice due to lack of validation studies. [...]
2021 - 10.3390/cancers13205052
Cancers, Vol. 13 (october 2021)
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4.
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14 p, 2.0 MB |
Effect of tumor burden and radical surgery on survival difference between upfront, early interval or delayed cytoreductive surgery in ovarian cancer
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Angeles, Martina Aida (Institut Universitaire du Cancer de Toulouse Oncopole) ;
Cabarrou, Bastien (Institut Universitaire du Cancer de Toulouse Oncopole) ;
Gil-Moreno, Antonio 1965- (Vall d'Hebron Institut d'Oncologia) ;
Pérez-Benavente, Assumpció (Vall d'Hebron Institut d'Oncologia) ;
Spagnolo, Emanuela (Hospital Universitario La Paz (Madrid)) ;
Rychlik, Agnieszka (Department of Gynaecologic Oncology, Maria Skłodowska-Curie National Research Institute of Oncology) ;
Martínez-Gómez, Carlos (INSERM CRCT 1 (França)) ;
Guyon, Frédéric (Department of Surgical Oncology, Institut Bergonié (França)) ;
Zapardiel, Ignacio (Hospital Universitario La Paz (Madrid)) ;
Querleu, Denis (Honorary Professor of the University of Toulouse) ;
Illac, Claire (Institut Universitaire du Cancer de Toulouse Oncopole) ;
Migliorelli, Federico (Department of Gynaecology and Obstetrics, Centre Hospitalier Intercommunal des Vallées de l'Ariège (França)) ;
Bétrian, Sarah (Institut Universitaire du Cancer de Toulouse Oncopole) ;
Ferron, Gwénaël (INSERM CRCT 19 (França)) ;
Hernández Gutierrez, Alicia (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ;
Martinez, Alejandra (INSERM CRCT 19 (França)) ;
Universitat Autònoma de Barcelona
We sought to evaluate the impact on survival of tumor burden and surgical complexity in relation to the number of cycles of neoadjuvant chemotherapy (NACT) in patients with advanced ovarian cancer (OC) with minimal (CC-1) or no residual disease (CC-0). [...]
2021 - 10.3802/jgo.2021.32.e78
Journal of Gynecologic Oncology, Vol. 32 (august 2021)
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5.
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15 p, 603.6 KB |
Surgical Outcomes of Laparoscopic Pelvic Lymph Node Debulking during Staging Aortic Lymphadenectomy in Locally Advanced Cervical Cancer : A Multicenter Study
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Díaz-Feijoo, Berta (Hospital Clínic i Provincial de Barcelona) ;
Acosta, Úrsula (Vall d'Hebron Institut d'Oncologia) ;
Torne, Aureli (Hospital Clínic i Provincial de Barcelona) ;
Gil-Ibáñez, Blanca (Hospital 12 de Octubre (Madrid)) ;
Hernández Gutierrez, Alicia (Hospital Universitario La Paz (Madrid)) ;
Domingo, Santiago (Hospital Universitari i Politècnic La Fe (València)) ;
Bradbury, Melissa (Vall d'Hebron Institut d'Oncologia) ;
Gil-Moreno, Antonio 1965- (Centro de Investigación Biomédica en Red de Cáncer) ;
Universitat Autònoma de Barcelona
Lymph node metastasis is an important prognostic factor in locally advanced cervical cancer (LACC), which makes correct staging crucial. In contrast to existing studies evaluating pelvic lymphadenectomy after aortic lymphadenectomy, this study focuses on the pelvic node (PLN) debulking technique which has the dual objective of staging and cytoreduction. [...]
2022 - 10.3390/cancers14081974
Cancers, Vol. 14 (april 2022)
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10 p, 814.8 KB |
Tumor Size and Oncological Outcomes in Patients with Early Cervical Cancer Treated by Fertility Preservation Surgery : A Multicenter Retrospective Cohort Study
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Gil-Ibañez, Blanca (Hospital Universitario 12 de Octubre (Madrid)) ;
Gil-Moreno, Antonio 1965- (Hospital Universitari Vall d'Hebron) ;
Torne, Aureli (Hospital Clínic i Provincial de Barcelona) ;
Martin-Jimenez, Angel (Hospital Universitario Son Llàtzer (Illes Balears)) ;
Gorostidi, Mikel (Hospital Universitario de Donostia.(Sant Sebastià, País Basc)) ;
Zapardiel, Ignacio (Hospital Universitario 12 de Octubre (Madrid)) ;
Díaz-Feijoo, Berta (Hospital Clínic i Provincial de Barcelona) ;
Universitat Autònoma de Barcelona
As cervical cancer is increasingly diagnosed in women who still intend to have children, fertility-sparing surgery is arising as a treatment option for those women with early-stage cervical cancer. The aim of this study was to analyze surgical, oncological and obstetrical outcomes of fertility-sparing surgery in early cervical cancer in Spain. [...]
2022 - 10.3390/cancers14092108
Cancers, Vol. 14 (april 2022)
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7.
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22 p, 3.0 MB |
Genomic Validation of Endometrial Cancer Patient-Derived Xenograft Models as a Preclinical Tool
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Villafranca-Magdalena, Beatriz (Universitat Autònoma de Barcelona) ;
Masferrer-Ferragutcasas, Carina (Universitat Autònoma de Barcelona) ;
López-Gil, Carlos (Universitat Autònoma de Barcelona) ;
Coll de la Rubia, Eva (Universitat Autònoma de Barcelona) ;
Rebull, Marta (Universitat Autònoma de Barcelona) ;
Parra, Genis (Centre de Regulació Genòmica) ;
García, Ángel (Hospital Universitari Vall d'Hebron) ;
Reques, Armando (Hospital Universitari Vall d'Hebron) ;
Cabrera Díaz, Silvia (Vall d'Hebron Institut d'Oncologia) ;
Colás Ortega, Eva (Universitat Autònoma de Barcelona) ;
Gil-Moreno, Antonio 1965- (Vall d'Hebron Institut d'Oncologia) ;
Moiola, Cristian Pablo (Universitat Autònoma de Barcelona)
Endometrial cancer (EC) is the second most frequent gynecological cancer worldwide. Although improvements in EC classification have enabled an accurate establishment of disease prognosis, women with a high-risk or recurrent EC face a dramatic situation due to limited further treatment options. [...]
2022 - 10.3390/ijms23116266
International journal of molecular sciences, Vol. 23 (june 2022)
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14 p, 1.4 MB |
Fertility-Sparing Surgery versus Radical Hysterectomy in Early Cervical Cancer : A Propensity Score Matching Analysis and Noninferiority Study
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Llueca, Antoni (University Jaume I (UJI)) ;
Ibañez, Maria Victoria (University Jaume I (UJI)) ;
Torne, Aureli (Hospital Clínic i Provincial de Barcelona) ;
Gil-Moreno, Antonio 1965- (Vall d'Hebron Institut d'Oncologia) ;
Martin-Jimenez, Angel (Hospital Universitari Son Llàtzer (Palma de Mallorca, Balears)) ;
Díaz-Feijoo, Berta (Hospital Clínic i Provincial de Barcelona) ;
Serra Rubert, Anna (University Jaume I (UJI)) ;
Climent, Maria Teresa (University Jaume I (UJI)) ;
Gil-Ibañez, Blanca (Hospital 12 de Octubre (Madrid)) ;
Universitat Autònoma de Barcelona
Fertility-sparing surgery (FSS) is the treatment of choice for patients with early cervical cancer (ECC) and fertility desire, but survival rates compared to radical hysterectomy (RH) have been scarcely reported. [...]
2022 - 10.3390/jpm12071081
Journal of personalized medicine, Vol. 12 (june 2022)
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10 p, 564.4 KB |
Accuracy and Survival Outcomes after National Implementation of Sentinel Lymph Node Biopsy in Early Stage Endometrial Cancer
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Cabrera Díaz, Silvia (Hospital Universitari Vall d'Hebron) ;
Gómez-Hidalgo, Natalia R (Hospital Universitari Vall d'Hebron) ;
Bebia, Vicente (Hospital Universitari Vall d'Hebron) ;
Fernández-González, Sergi (Hospital Universitari de Bellvitge) ;
Fusté, Pere (Hospital Clínic i Provincial de Barcelona) ;
Martínez, Sergio (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gil-Moreno, Antonio 1965- (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Sentinel lymph node (SLN) biopsy has recently been accepted to evaluate nodal status in endometrial cancer at early stage, which is key to tailoring adjuvant treatments. Our aim was to evaluate the national implementation of SLN biopsy in terms of accuracy to detect nodal disease in a clinical setting and oncologic outcomes according to the volume of nodal disease. [...]
Springer New York, 2023 - 10.1245/s10434-023-14068-0
Annals of Surgical Oncology
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13 p, 1.7 MB |
A combination of molecular and clinical parameters provides a new strategy for high-grade serous ovarian cancer patient management
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Bradbury, Melissa (Hospital Universitari Vall d'Hebron) ;
Borràs, Eva (Universitat Pompeu Fabra) ;
Vilar, Marta (Hospital Universitari Vall d'Hebron) ;
Castellvi, Josep (Hospital Universitari Vall d'Hebron) ;
Sanchez Iglesias, Jose Luis (Hospital Universitari Vall d'Hebron) ;
Pérez-Benavente, Assumpció (Hospital Universitari Vall d'Hebron) ;
Gil-Moreno, Antonio 1965- (Hospital Universitari Vall d'Hebron) ;
Fàbrega-Santamaria, Anna (Hospital Universitari Vall d'Hebron) ;
Sabidó, Eduard (Universitat Pompeu Fabra) ;
Universitat Autònoma de Barcelona
High-grade serous carcinoma (HGSC) is the most common and deadly subtype of ovarian cancer. Although most patients will initially respond to first-line treatment with a combination of surgery and platinum-based chemotherapy, up to a quarter will be resistant to treatment. [...]
2022 - 10.1186/s12967-022-03816-7
Journal of translational medicine, Vol. 20 (december 2022)
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