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12 p, 4.7 MB Dopaminergic and glutamatergic signaling crosstalk in Huntington's disease neurodegeneration : the role of p25/cyclin-dependent kinase 5 / Paoletti, Paola (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Vila, Ingrid (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Rifé, Maria (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Lizcano de Vega, José Miguel (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Alberch i Vié, Jordi (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Ginés, Silvia (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Altered glutamatergic and dopaminergic signaling has been proposed as contributing to the specific striatal cell death observed in Huntington's disease (HD). However, the precise mechanisms by which mutant huntingtin sensitize striatal cells to dopamine and glutamate inputs remain unclear. [...]
2008 - 10.1523/JNEUROSCI.3237-08.2008
The Journal of neuroscience, Vol. 28 No. 40 (Oct. 2008) , p. 10090-10101  

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