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35 p, 2.1 MB Modeling Fanconi anemia pathogenesis and therapeutics using integration-free patient iPSCs / Liu, Guang-Hui (Salk Institute for Biological Studies (La Jolla, Estats Units d'Amèrica). Laboratory of Gene Expression) ; Suzuki, Keiichiro (Salk Institute for Biological Studies (La Jolla, Estats Units d'Amèrica). Laboratory of Gene Expression) ; Li, Mo (Salk Institute for Biological Studies (La Jolla, Estats Units d'Amèrica). Laboratory of Gene Expression) ; Qu, Jing (Salk Institute for Biological Studies (La Jolla, Estats Units d'Amèrica). Laboratory of Gene Expression) ; Montserrat, Núria (Centro de Medicina Regenerativa de Barcelona) ; Tarantino, Carolina (Centro de Medicina Regenerativa de Barcelona) ; Gu, Ying (Salk Institute for Biological Studies (La Jolla, Estats Units d'Amèrica). Laboratory of Gene Expression) ; Yi, Fei (Salk Institute for Biological Studies (La Jolla, Estats Units d'Amèrica). Laboratory of Gene Expression) ; Xu, Xiuling (Zhongguo ke xue yuan. National Laboratory of Biomacromolecules) ; Zhang, Weiqi (Zhongguo ke xue yuan. National Laboratory of Biomacromolecules) ; Ruiz, Sergio (Salk Institute for Biological Studies (La Jolla, Estats Units d'Amèrica). Laboratory of Gene Expression) ; Plongthongkum, Nongluk (University of California. Department of Bioengineering) ; Zhang, Kun (University of California. Department of Bioengineering) ; Masuda, Shigeo (Salk Institute for Biological Studies (La Jolla, Estats Units d'Amèrica). Laboratory of Gene Expression) ; Nivet, Emmanuel (Salk Institute for Biological Studies (La Jolla, Estats Units d'Amèrica). Laboratory of Gene Expression) ; Tsunokawa, Yuji (Salk Institute for Biological Studies (La Jolla, Estats Units d'Amèrica). Laboratory of Gene Expression) ; Soligalla, Rupa Devi (Salk Institute for Biological Studies (La Jolla, Estats Units d'Amèrica). Laboratory of Gene Expression) ; Goebl, April (Salk Institute for Biological Studies (La Jolla, Estats Units d'Amèrica). Laboratory of Gene Expression) ; Aizawa, Emi (Salk Institute for Biological Studies (La Jolla, Estats Units d'Amèrica). Laboratory of Gene Expression) ; Kim, Na Young (Salk Institute for Biological Studies (La Jolla, Estats Units d'Amèrica). Laboratory of Gene Expression) ; Kim, Jessica (Salk Institute for Biological Studies (La Jolla, Estats Units d'Amèrica). Laboratory of Gene Expression) ; Dubova, Ilir (Salk Institute for Biological Studies (La Jolla, Estats Units d'Amèrica). Laboratory of Gene Expression) ; Li, Ying (Zhongguo ke xue yuan. National Laboratory of Biomacromolecules) ; Ren, Ruotong (Zhongguo ke xue yuan. National Laboratory of Biomacromolecules) ; Benner, Chris (Salk Institute for Biological Studies (La Jolla, Estats Units d'Amèrica)) ; Sol, Antonio del (Luxembourg Centre for Systems Biomedicine) ; Bueren, Juan (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ; Trujillo Quintero, Juan Pablo (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Surrallés i Calonge, Jordi (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Cappelli, Enrico (Istituto "Giannina Gaslini" di Genova) ; Dufour, Carlo (Istituto "Giannina Gaslini" di Genova) ; Rodriguez Esteban, Concepción (Salk Institute for Biological Studies (La Jolla, Estats Units d'Amèrica). Laboratory of Gene Expression) ; Izpisúa Belmonte, Juan Carlos (Salk Institute for Biological Studies (La Jolla, Estats Units d'Amèrica). Laboratory of Gene Expression)
Fanconi anaemia (FA) is a recessive disorder characterized by genomic instability, congenital abnormalities, cancer predisposition and bone marrow (BM) failure. However, the pathogenesis of FA is not fully understood partly due to the limitations of current disease models. [...]
Altres ajuts: Strategic Priority Research Program of the Chinese Academy of Sciences (XDA01020312), National Basic Research Program of China (973 Program,2014CB964600;2014CB910500), NSFC (81271266, 31222039, 81330008, 31201111, 81371342, 81300261, 81300677), Key Research Program of the Chinese Academy of Sciences (KJZD-EW-TZ-L05), Beijing Natural Science Foundation (7141005; 5142016), the Thousand Young Talents program of China, National Laboratory of Biomacromolecules (012kf02, 2013kf05;2013kf11;2014kf02), and State Key Laboratory of Drug Research (SIMM1302KF-17). [...]

2014 - 10.1038/ncomms5330
Nature communications, Vol. 5, article 4330 (July 2014)  

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