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Off-label use of rituximab for systemic lupus erythematosus in Europe IB: speaker fees from MSD and Lilly Netherlands. TD: study support by Roche, UCB and Sanofi; honoraria for scientific advice from Roche, Chugai, Sanofi, Eli Lilly and UCB. FAH and MI: research grants from Roche. DI: acted as an adviser to a number of companies in the past 5 years, including GlaxoSmithKline, Eli Lilly and Roche; the honoraria offered are passed on to a local arthritis charity. RvV: research support and grants. For performing the analyses reported here, which were requested by the European Medicines Agency (EMA), the authors received an unrestricted grant from Roche. Other: AbbVie, Amgen, BMS, GSK, Pfizer, UCB. Consultancy, honoraria: AbbVie, Biotest, BMS, Celgene, Crescendo, GSK, Janssen, Lilly, Merck, Novartis, Pfizer, Roche, UCB and Vertex
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Rydén-Aulin, Monica (Karolinska Institutet, Karolinska University Hospital) ;
Boumpas, Dimitrios (Medical School, National and Kapodestrian University of Athens, Attikon University Hospital) ;
Bultink, Irene (Amsterdam Rheumatology and Immunology Center) ;
Callejas Rubio, Jose Luis (Hospital San Cecilio) ;
Caminal-Montero, Luis (Hospital Universitario Central de Asturias) ;
Castro, Antoni (University Hospital Sant Joan de Reus, Rovira i Virgili University (URV)-IISPV) ;
Colodro Ruiz, Agustín (Pasaje Nueva Victoria, 2, 2do C) ;
Doria, Andrea (University of Padova) ;
Dörner, Thomas (Charite Universitaetsmedizin Berlin) ;
Gonzalez-Echavarri, Cristina (BioCruces Health Research Institute, Cruces University Hospital, University of the Basque Country) ;
Gremese, Elisa (Institute of Rheumatology and Affine Sciences (IRSA), Catholic University of the Sacred Heart) ;
Houssiau, Frederic A (Cliniques Universitaires Saint-Luc, Pôle de Pathologies Rhumatismales Inflammatoires et Systémiques, Université Catholique de Louvain) ;
Huizinga, Tom (C1-41, Leiden University Medical Center) ;
Inanç, Murat (Istanbul University) ;
Isenberg, David (University College London, The Rayne Building) ;
Iuliano, Annamaria (San Camillo Hospital) ;
Jacobsen, Søren (Copenhagen Lupus and Vasculitis Clinic, Center for Rheumatology and Spine Diseases, University of Copenhagen, Rigshospitalet) ;
Jimenéz-Alonso, Juan (Universitary 'Virgen de las Nieves' Hospital) ;
Kovács, Lászlo (Albert Szent-Györgyi Health Centre, University of Szeged) ;
Mariette, Xavier (Rhumatologie Responsable de l'Unité de Recherche Clinique, Hôpitaux Universitaire Paris-Sud, Université Paris-Sud, INSERM U1184) ;
Mosca, Marta (Rheumatology Unit, Pisa) ;
Nived, Ola (Rheumatology Clinic, Skåne University Hospital) ;
Oristrell, Joaquim (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Ramos-Casals, Manuel (ICMiD, Josep Font Autoimmune Lab, CELLEX-IDIBAPS) ;
Rascón, Javier (Carrer de les Sabateres, 9-1, Alaró) ;
Ruiz-Irastorza, Guillermo (BioCruces Health Research Institute, Cruces University Hospital, University of the Basque Country) ;
Sáez-Comet, Luis (Unidad de Enfermedades Autoinmunes Sistémicas, Hospital Universitario Miguel Servet de Zaragoza, Paseo Isabel la Católica) ;
Salvador Cervelló, Gonzalo (Hospital Universitario y Politecnico La Fe) ;
Sebastiani, Gian Domenico (UOC Reumatologia, Ospedale San Camillo, Circonvallazione Gianicolense n. 87) ;
Squatrito, Danilo (University of Florence) ;
Szücs, Gabriella (Institute of Medicine, University of Debrecen) ;
Voskuyl, Alexandre (Amsterdam Rheumatology and Immunology Center (ARC), VU University Medical Center) ;
van Vollenhoven, Ronald (Amsterdam Rheumatology and Immunology Center ARC, AMC mail F4-105)
Rituximab (RTX) is a biological treatment used off-label in patients with systemic lupus erythematosus (SLE). This survey aimed to investigate the off-label use of RTX in Europe and compare the characteristics of patients receiving RTX with those receiving conventional therapy. [...]
2016 -  10.1136/lupus-2016-000163
Lupus Science & Medicine, Vol. 3 (september 2016)
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Enantioselective approach to indolizidine and quinolizidine scaffolds : application to the synthesis of peptide mimics
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Lu, Yuanyuan (Universitat Autònoma de Barcelona. Departament de Química) ;
Alujas Burgos, Sílvia (Universitat Autònoma de Barcelona. Departament de Química) ;
Oliveras González, Cristina (Universitat Autònoma de Barcelona. Departament de Química) ;
Vázquez Jiménez, Laura (Universitat Autònoma de Barcelona. Departament de Química) ;
Rojo, Pep (Universitat Autònoma de Barcelona. Departament de Química) ;
Alvarez-Larena, Angel (Universitat Autònoma de Barcelona. Servei de Cristal·lografia) ;
Bayón Rueda, Joan Pau (Universitat Autònoma de Barcelona. Departament de Química) ;
Figueredo Galimany, Marta (Universitat Autònoma de Barcelona. Departament de Química)
An enantioselective approach to substituted indolizidine and quinolizidine frameworks has been developed. Key steps of the synthesis are the enantioselective, palladium-catalyzed N-allylation of an imide, the nucleophilic allylation of an acyliminium ion and a ring closing metathesis. [...]
2018 - 10.1016/j.tet.2017.11.042
Tetrahedron, Vol. 74, issue 1 (Jan. 2018) , p. 104-116
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15 p, 1.7 MB |
Genome-wide analysis of factors affecting transcription elongation and DNA repair : a new role for PAF and Ccr4-not in transcription-coupled repair
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Gaillard, Hélène (Centro Andaluz de Biología Molecular y Medicina Regenerativa (Sevilla, Andalusia)) ;
Tous, Cristina (Centro Andaluz de Biología Molecular y Medicina Regenerativa (Sevilla, Andalusia)) ;
Botet, Javier (Universidad de Sevilla. Departamento de Genética) ;
González Aguilera, Cristina (Centro Andaluz de Biología Molecular y Medicina Regenerativa (Sevilla, Andalusia)) ;
Quintero, María José (Universidad de Sevilla. Departamento de Genética) ;
Viladevall Masbernat, Laia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
García Rubio, María L. (Centro Andaluz de Biología Molecular y Medicina Regenerativa (Sevilla, Andalusia)) ;
Rodríguez Gil, Alfonso (Universidad de Sevilla. Departamento de Genética) ;
Marín Rodríguez, Antonio (Universidad de Sevilla. Departamento de Genética) ;
Ariño Carmona, Joaquín (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Revuelta, José Luis (Instituto de Microbiología Bioquímica (Salamanca, Castella i Lleó)) ;
Chávez, Sebastián (Universidad de Sevilla. Departamento de Genética) ;
Aguilera, Andrés (Centro Andaluz de Biología Molecular y Medicina Regenerativa (Sevilla, Andalusia))
RNA polymerases frequently deal with a number of obstacles during transcription elongation that need to be removed for transcription resumption. One important type of hindrance consists of DNA lesions, which are removed by transcription-coupled repair (TC-NER), a specific sub-pathway of nucleotide excision repair. [...]
2009 - 10.1371/journal.pgen.1000364
PLoS Genetics, Vol. 5, Issue 2 (February 2009) , p. e1000364
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