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1.
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10 p, 1.1 MB |
Metabolic polygenic risk scores effect on antipsychotic-induced metabolic dysregulation : A longitudinal study in a first episode psychosis cohort
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Segura, Àlex G. (Universitat de Barcelona) ;
Martínez-Pinteño, Albert (Universitat de Barcelona) ;
Gassó, Patricia (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Rodríguez, Natalia (Universitat de Barcelona) ;
Bioque, Miquel (Hospital Clínic i Provincial de Barcelona) ;
Cuesta, Manuel J. (Instituto de Investigación Sanitaria de Navarra) ;
González-Peñas, Javier (Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM)) ;
Garcia Rizo, Clemente (Hospital Clínic i Provincial de Barcelona) ;
Lobo, Antonio (Instituto de Investigación Sanitaria Aragón) ;
González-Pinto, Ana (Universidad del País Vasco) ;
García-Alcón, Alicia (Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM)) ;
Roldán, Alejandra (Institut d'Investigació Biomèdica Sant Pau) ;
Vieta, Eduardo (Universitat de Barcelona) ;
Castro-Fornieles, Josefina (Hospital Clínic i Provincial de Barcelona) ;
Mané, Anna (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Saiz, Jerónimo (Hospital Universitario Ramón y Cajal (Madrid)) ;
Bernardo, Miguel (Universitat de Barcelona) ;
Mas, Sergi (Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ;
Universitat Autònoma de Barcelona
Metabolic syndrome is a health-threatening condition suffered by approximately one third of schizophrenia patients and largely attributed to antipsychotic medication. Previous evidence reports a common genetic background of psychotic and metabolic disorders. [...]
2022 -  10.1016/j.schres.2022.05.021
Schizophrenia Research, Vol. 244 (june 2022) , p. 101-110
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2.
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9 p, 871.1 KB |
Gene co-expression architecture in peripheral blood in a cohort of remitted first-episode schizophrenia patients
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Rodríguez, Natalia (Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPs)) ;
Gassó, Patricia (Centro de Investigación Biomédica en red en salud Mental (CIBERSAM)) ;
Martínez-Pinteño, Albert (Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPs)) ;
Segura, Àlex-González (Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPs)) ;
Mezquida, Gisela (Hospital Clínic i Provincial de Barcelona) ;
Moreno-Izco, Lucia (Instituto de Investigación Sanitaria de Navarra) ;
González-Peñas, Javier (Centro de Investigación Biomédica en Red de Salud Mental) ;
Zorrilla, Iñaki (Universidad del País Vasco) ;
Martin, Marta (Institut d'Investigació Biomèdica Sant Pau) ;
Rodriguez-Jimenez, Roberto (Universidad Complutense de Madrid) ;
Corripio, Iluminada (Universitat Autònoma de Barcelona) ;
Sarró, Salvador (Universitat Internacional de Catalunya) ;
Ibáñez, Angela (Hospital Universitario Ramón y Cajal) ;
Butjosa, Anna (Hospital Sant Joan de Déu (Manresa)) ;
Contreras, Fernando (Centro de Investigación Biomédica en red en salud Mental (CIBERSAM)) ;
Bioque, Miquel (Universitat de Barcelona) ;
Cuesta, Manuel-Jesús (Hospital General Universitario Gregorio Marañón) ;
Parellada, Mara (Centro de Investigación Biomédica en Red de Salud Mental) ;
González-Pinto, Ana (Universidad del País Vasco) ;
Berrocoso, Esther (Instituto de Investigación e Innovación Biomédica de Cádiz) ;
Bernardo, Miquel (Universitat de Barcelona) ;
Mas, Sergi (Centro de Investigación Biomédica en red en salud Mental (CIBERSAM)) ;
Amoretti S, Silvia (Hospital Clínic i Provincial de Barcelona) ;
Moren, Constanza (Centro deInvestigación Biomédica en Red (CIBER) de Enfermedades Raras (CIBERER)) ;
Stella, Carol (Centro de Investigación Biomédica en Red de Salud Mental) ;
Gurriarán, Xaquin (Centro de Investigación Biomédica en Red de Salud Mental) ;
Alonso-Solís, Anna (Universitat Autònoma de Barcelona) ;
Grasa, Eva (Universitat Autònoma de Barcelona) ;
Fernandez, Jessica (Universidad del País Vasco) ;
Gonzalez-Ortega, Itxaso (Universidad del País Vasco) ;
Casanovas, Francesc (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Bulbuena, Antoni (Universitat Autònoma de Barcelona) ;
Núñez-Doyle, Ágatha (Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12)) ;
Jiménez-Rodríguez, Olga (Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12)) ;
Pomarol-Clotet, Edith (Centro de Investigación Biomédica en Red de Salud Mental) ;
Feria-Raposo, Isabel (Benito Menni CASM) ;
Usall, Judith (Institut de Recerca Sant Joan de Déu) ;
Muñoz-Samons, Daniel (Hospital Materno-Infantil Sant Joan de Déu) ;
Ilundain, Jose L. (Instituto de Investigación Sanitaria de Navarra) ;
Sánchez-Torres, Ana Maria (Instituto de Investigación Sanitaria de Navarra) ;
Saiz-Ruiz, Jeronimo (Universidad de Alcalá) ;
López-Torres, Isabel (Hospital Universitario Ramón y Cajal) ;
Nacher, Juan (Instituto de Investigación Sanitaria INCLIVA (València, Comunitat Valenciana)) ;
De-la-Cámara, Concepción (Centro de Investigación Biomédica en red en salud Mental (CIBERSAM)) ;
Gutiérrez, Miguel (Arabako Unibertsitate Ospitalea (Vitoria, País Basc)) ;
Sáiz, Pilar Alejandra (Instituto de Investigación Sanitaria del Principado de Asturias)
A better understanding of schizophrenia subtypes is necessary to stratify the patients according to clinical attributes. To explore the genomic architecture of schizophrenia symptomatology, we analyzed blood co-expression modules and their association with clinical data from patients in remission after a first episode of schizophrenia. [...]
2022 - 10.1038/s41537-022-00215-1
Schizophrenia, Vol. 8 Núm. 1 (december 2022) , p. 45
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3.
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9 p, 526.0 KB |
Burden of refractory and unexplained chronic cough on patients' lives : a cohort study
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Puente, Luis (=)) ;
Dávila, Ignacio (Hospital Clínico Universitario (Salamanca)) ;
Quirce Gancedo, Santiago (Hospital Universitario La Paz (Madrid)) ;
Crespo Lessmann, Astrid (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Martínez-Moragón, Eva (Hospital Universitari Doctor Peset (València)) ;
Sola, Javier (Hospital Universitario Ramón y Cajal (Madrid)) ;
Nieto, María Luisa (Hospital Arnau de Vilanova (València)) ;
González-Barcala, Francisco-Javier (Universidad de Santiago de Compostela) ;
Cea-Calvo, Luis (Medical Affairs) ;
Sánchez-Jareño, Marta (Medical Affairs) ;
Rivas-Pardinas, Cristina (Medical Affairs) ;
Domingo, Christian (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Universitat Autònoma de Barcelona
Chronic cough (cough lasting for ≥8 weeks) can lead to significant impairment in quality of life (QoL). Using patient-reported outcomes, this cohort study assessed the perceived impact of chronic cough on QoL and everyday life in patients from outpatient hospital clinics with refractory chronic cough (RCC) or unexplained chronic cough (UCC). [...]
2023 - 10.1183/23120541.00425-2023
ERJ Open Research, Vol. 9 (september 2023)
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4.
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9 p, 464.1 KB |
Limitation of life support techniques at admission to the intensive care unit : A multicenter prospective cohort study
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Rubio, Olga (Hospital Sant Joan De Déu) ;
Arnau, Anna (Hospital Sant Joan De Déu) ;
Cano, Silvia (Hospital Sant Joan De Déu) ;
Subirà, Carles (Hospital Sant Joan De Déu) ;
Balerdi, Begoña (Hospital Universitari i Politècnic La Fe (València)) ;
Perea, María Eugenía (Hospital General Yagué de Burgos) ;
Fernández-Vivas, Miguel (Hospital Universitario Virgen de la Arrixaca (Múrcia)) ;
Barber, María (Complejo Hospitalario de Navarra) ;
Llamas, Noemí (Hospital Morales Messeguer) ;
Altaba, Susana (Hospital Universitario de Castellon) ;
Prieto, Ana (Hospital Rio Hortega) ;
Gómez, Vicente (Hospital la Moncloa) ;
Martin, Mar (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife)) ;
Paz, Marta (Hospital Clínico Universitario (Salamanca)) ;
Quesada, Belen (Hospital Universitario Fundación Jiménez Díaz) ;
Español, Valentí (Hospital Universitario Central de Asturias) ;
Montejo, Juan Carlos (Hospital 12 de Octubre (Madrid)) ;
Gomez, José Manuel (Hospital General Universitario Gregorio Marañón) ;
Miro, Gloria (Hospital Mataro) ;
Xirgú, Judith (Hospital General de Granollers) ;
Ortega Montes, Ana (Hospital Montecelo Pontevedra) ;
Rascado, Pedro (Centro Hospitalario Universitario Santiago Compostela) ;
Sánchez, Juan María (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Marcos, Alfredo (Hospital Virgen de la Concha (Zamora)) ;
Tizon, Ana (Hospital Xeral Cíes Vigo) ;
Monedero, Pablo (Clínica Universidad de Navarra) ;
Zabala, Elisabeth (Hospital Clínico Universitario de Barcelona) ;
Murcia, Cristina (Hospital Universitari de Girona Doctor Josep Trueta) ;
Torrejon, Ines (Hospital de Henares) ;
Planas, Kenneth (Hospital Moisses Broggi) ;
Añón, José Manuel (Hospital Virgen de La Luz (Cuenca)) ;
Hernandez, Gonzalo (Hospital Universitario Infanta Sofía (San Sebastián de los Reyes)) ;
Fernandez, María-del-Mar. (Hospital Universitari MútuaTerrassa) ;
Guía, Consuelo (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Arauzo, Vanesa (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Perez, José Miguel (Hospital Universitario Virgen de las Nieves (Granada)) ;
Catalan, Rosa (Hospital General de Vic) ;
Gonzalez, Javier (Hospital Virgen Vega Salamanca) ;
Poyo, Rosa (Hospital Son Llátzer) ;
Tomas, Roser (Hospital General de Catalunya) ;
Saralegui, Iñaki (Hospital de Áraba) ;
Mancebo, Jordi (Institut d'Investigació Biomèdica Sant Pau) ;
Sprung, Charles (Hadassh Hebrew University Medical Center) ;
Fernández, Rafael (Fundació Althaia Xarxa Universitaria de Manresa) ;
Universitat Autònoma de Barcelona
To determine the frequency of limitations on life support techniques (LLSTs) on admission to intensive care units (ICU), factors associated, and 30-day survival in patients with LLST on ICU admission. [...]
2018 - 10.1186/s40560-018-0283-y
Journal of Intensive Care, Vol. 6 Núm. 1 (13 2018) , p. 24
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5.
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104 p, 1.6 MB |
Neurobehavioral and neurodevelopmental profiles of a heuristic genetic model of differential schizophrenia- and addiction-relevant features: The RHA vs. RLA rats
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Fernández-Teruel, Alberto (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Oliveras, Ignasi (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Cañete, Toni (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Rio-Álamos, Cristóbal (Universidad Austral de Chile. Departamento de Psicologia) ;
Tapias-Espinosa, Carles (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Sampedro-Viana, Daniel (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Sánchez-González, Ana (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Sanna, Francesco (Universitá di Cagliari. Dipartimento di Scienze della vita e dell'ambiente) ;
Torrúbia, Rafael (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
González-Maeso, Javier (Virginia Commonwealth University School of Medicine. Department of Physiology and Biophysics) ;
Driscoll, Peter ;
Morón, Ignacio (Universidad de Granada. Departamento de Psicobiologia) ;
Torres, Carmen (Universidad de Jaén. Departamento de Psicología) ;
Aznar, Susana (Bispebjerg Copenhagen University Hospital) ;
Tobeña, Adolf 1950- (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Corda, Maria G. (Universitá di Cagliari. Dipartimento di Scienze della vita e dell'ambiente) ;
Giorgi, Osvaldo (Universitá di Cagliari. Dipartimento di Scienze della vita e dell'ambiente) ;
Universitat Autònoma de Barcelona.
Institut de Neurociències
The Roman High- (RHA) and Low-(RLA) avoidance rat lines/strains were generated through bidirectional selective breeding for rapid (RHA) vs. extremely poor (RLA) two-way active avoidance acquisition. [...]
2021 - 10.1016/j.neubiorev.2021.09.042
Neuroscience and Biobehavioral Reviews, Vol. 131 (2021) , p. 597-617
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6.
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22 p, 475.4 KB |
Increased thin-spine density in frontal cortex pyramidal neurons in a genetic rat model of schizophrenia-relevant features
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Sánchez González, Ana (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Thougaard, Estrid (Research Laboratory for Stereology and Neuroscience, Bispebjerg Copenhagen University Hospital) ;
Tapias-Espinosa, Carles (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Cañete, Toni (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Sampedro-Viana, Daniel (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Saunders, Justin M. (Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine) ;
Toneatti, Rudy (Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine) ;
Tobeña, Adolf 1950- (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Gonzalez-Maeso, Javier (Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine) ;
Aznar, Susana (Research Laboratory for Stereology and Neuroscience, Bispebjerg Copenhagen University Hospital) ;
Fernández-Teruel, Alberto (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Universitat Autònoma de Barcelona.
Institut de Neurociències
The cellular mechanisms altered during brain wiring leading to cognitive disturbances in neurodevelopmental disorders remain unknown. We have previously reported altered cortical expression of neurodevelopmentally regulated synaptic markers in a genetic animal model of schizophrenia-relevant behavioral features, the Roman-High Avoidance rat strain (RHA-I). [...]
2021 - 10.1016/j.euroneuro.2021.01.006
European neuropsychopharmacology, Vol. 44 (March 2021) , p. 79-91
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33 p, 1.2 MB |
Metabotropic Glutamate Receptor 2 and Dopamine Receptor 2 Gene Expression Predict Sensorimotor Gating Response in the Genetically Heterogeneous NIH-HS Rat Strain
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Østerbøg, Tina Becher (Research Laboratory for Stereology and Neuroscience. Bispebjerg and Frederiksberg Hospitals. Copenhagen) ;
On, Doan Minh (Department of Physiology and Biophysics. Virginia Commonwealth University School of Medicine) ;
Oliveras, Ignasi (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Río-Álamos, Cristobal (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Sánchez González, Ana (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Tapias-Espinosa, Carles (Departamento de Psiquiatría y Medicina Legal.) ;
Tobeña, Adolf 1950- (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Gonzalez-Maeso, Javier (Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine) ;
Fernández-Teruel, Alberto (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Aznar, Susana (Bispebjerg and Frederiksberg Hospitals (Copenhagen, Dinamarca))
Disruption of sensorimotor gating causes "flooding" of irrelevant sensory input and is considered a congenital trait in several neurodevelopmental disorders. Prepulse inhibition of acoustic startle response (PPI) is the operational measurement and has a high translational validity. [...]
2020 - 10.1007/s12035-019-01829-w
Molecular neurobiology, Vol. 57 Núm. 3 (March 2020) , p. 1516-1528
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8.
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10 p, 1.8 MB |
A proposed approach to chronic airway disease (CAD) using therapeutic goals and treatable traits : A look to the future
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Pérez de Llano, Luis (University Hospital Lucus Augusti (Lugo, Galícia)) ;
Miravitlles, Marc (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Golpe, Rafael (University Hospital Lucus Augusti (Lugo, Galícia)) ;
Alvarez Gutiérrez, Francisco Javier (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Cisneros, Carolina (Hospital Universitario La Princesa (Madrid)) ;
Almonacid, Carlos (Hospital Universitario Ramón y Cajal (Madrid)) ;
Martínez-Moragón, Eva (Hospital Universitari Doctor Peset (València)) ;
González-Barcala, Francisco-Javier (Universidade de Santiago de Compostela) ;
Ramos-Barbón, David (Institut d'Investigació Biomèdica Sant Pau) ;
Plaza, Vicente (Institut d'Investigació Biomèdica Sant Pau) ;
López-Campos, José Luis (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
De Torres, Juan Pablo (Queen's University) ;
Casanova Macario, Ciro (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife)) ;
García-Rivero, J. L. (Hospital de Laredo) ;
Rodriguez Hermosa, Juan Luis (Hospital Clínico San Carlos (Madrid)) ;
Calle Rubio, Myriam (Hospital Clínico San Carlos (Madrid)) ;
Soler-Cataluña, Juan José (Hospital Arnau de Vilanova (València)) ;
Cosio, Borja G (Clínica Quirón-Rotger) ;
Universitat Autònoma de Barcelona
Chronic airflow obstruction affects a wide range of airway diseases, the most frequent of which are asthma, COPD, and bronchiectasis; they are clearly identifiable in their extremes, but quite frequently overlap in some of their pathophysiological and clinical characteristics. [...]
2020 - 10.2147/COPD.S263430
International journal of COPD, Vol. 15 (2020) , p. 2091-2100
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9.
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6 p, 251.2 KB |
How reliably can algorithms identify eosinophilic asthma phenotypes using non-invasive biomarkers?
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Betancor, Diana (Hospital Universitario Fundación Jiménez Díaz) ;
Olaguibel, José María (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Rodrigo-Muñoz, José Manuel (Hospital Universitario Fundación Jiménez Díaz) ;
Arismendi, Ebymar (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Barranco, Pilar (Hospital Universitario La Paz (Madrid)) ;
Barroso, Blanca (Hospital Universitario Fundación Jiménez Díaz) ;
Bobolea, Irina (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Cárdaba, Blanca (Hospital Universitario Fundación Jiménez Díaz) ;
Cruz, María Jesús (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Curto Sánchez, Elena (Institut d'Investigació Biomèdica Sant Pau) ;
Del Pozo, Victoria (Hospital Universitario Fundación Jiménez Díaz) ;
González-Barcala, Francisco-Javier (Complejo Hospitalario Universitario de Santiago de Compostela) ;
Martínez Rivera, Carlos (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Mullol, Joaquim (Universitat de Barcelona) ;
Muñoz Gall, Xavier (Hospital Universitari Vall d'Hebron) ;
Picado, Cesar (Universitat de Barcelona) ;
Plaza, Vicente (Institut d'Investigació Biomèdica Sant Pau) ;
Quirce Gancedo, Santiago (Hospital Universitario La Paz (Madrid)) ;
Rial, Manuel Jorge (Complejo Hospitalario Universitario de A Coruña) ;
Soto-Retes, Lorena (Institut d'Investigació Biomèdica Sant Pau) ;
Valero, Antonio (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Valverde-Monge, Marcela (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Sastre, Joaquin (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias)
Asthma is a heterogeneous respiratory disease that encompasses different inflammatory and functional endophenotypes. Many non-invasive biomarkers has been investigated to its pathobiology. Heany et al proposed a clinical algorithm that classifies severe asthmatic patients into likely-eosinophilic phenotypes, based on accessible biomarkers: PBE, current treatment, FeNO, presence of nasal polyps (NP) and age of onset. [...]
2022 - 10.1002/clt2.12182
Clinical and translational allergy, Vol. 12, Issue 8 (August 2022) , art. e12182
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10.
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17 p, 1.5 MB |
Multi-ancestry genome-wide association study of asthma exacerbations
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Herrera-Luis, Esther (Universidad de La Laguna. Departamento de Bioquímica, Microbiología, Biología Celular y Genética) ;
Ortega, Victor E. (División de Medicina Respiratoria. Departamento de Medicina Interna. Mayo Clinic) ;
Ampleford, Elizabeth J. (Department of Internal Medicine. Center for Precision Medicine. Wake Forest School of Medicine) ;
Sio, Yang Yie (Department of Biological Sciences. National University of Singapore) ;
Granell, Raquel (MRC Integrative Epidemiology Unit (IEU). Population Health Sciences. Bristol Medical School. University of Bristol) ;
de Roos, Emmely (Department of Respiratory Medicine. Ghent University Hospital) ;
Terzikhan, Natalie (Department of Respiratory Medicine. Ghent University Hospital) ;
Vergara, Ernesto Elorduy (Institute of Computation Biology. Helmholtz Zentrum München. German Research Center for Environmental Health) ;
Hernandez-Pacheco, Natalia (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Perez-Garcia, Javier (Universidad de La Laguna. Departamento de Bioquímica, Microbiología, Biología Celular y Genética) ;
Martin-Gonzalez, Elena (Universidad de La Laguna. Departamento de Bioquímica, Microbiología, Biología Celular y Genética) ;
Lorenzo-Diaz, Fabian (Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias. Universidad de La Laguna) ;
Hashimoto, Simone (Department of Respiratory Medicine. Amsterdam University Medical Center. University of Amsterdam) ;
Brinkman, Paul (Department of Respiratory Medicine. Amsterdam University Medical Center. University of Amsterdam) ;
Jorgensen, Andrea L. (Department of Health Data Science. Institute of Population Health. University of Liverpool) ;
Yan, Qi (Department of Obstetrics and Gynecology. Columbia University Irving Medical Center) ;
Forno, Erick (Division of Pediatric Pulmonary Medicine. UPMC Children's Hospital of Pittsburgh. University of Pittsburgh) ;
Vijverberg, Susanne J. (Department of Paediatric Respiratory Medicine and Allergy. Emma's Children Hospital. Amsterdam UMC. University of Amsterdam) ;
Lethem, Ryan (MRC Integrative Epidemiology Unit (IEU). Population Health Sciences. Bristol Medical School. University of Bristol) ;
Espuela-Ortiz, Antonio (Universidad de La Laguna. Departamento de Bioquímica, Microbiología, Biología Celular y Genética) ;
Gorenjak, Mario (Center for Human Molecular Genetics and Pharmacogenomics. Faculty of Medicine. University of Maribor) ;
Eng, Celeste (Department of Medicine. University of California San Francisco) ;
González-Pérez, Ruperto (Unidad de Asma Grave. Servicio de Alergología. Hospital Universitario de Canarias.) ;
Hernández-Pérez, José M. (Hospital General de La Palma. Servicio de Neumología) ;
Poza-Guedes, Paloma (Hospital Universitario de Canarias. Unidad de Asma Grave. Servicio de Alergología) ;
Sardón, Olaia (Universidad del País Vasco. Departamento de Pediatría) ;
Corcuera, Paula (Hospital Universitario Donostia. Division of Pediatric Respiratory Medicine) ;
Hawkins, Greg A. (Department of Biochemistry. Wake Forest School of Medicine) ;
Marsico, Annalisa (Computational Health Center. Helmholtz Zentrum München. German Research Center for Environmental Health) ;
Bahmer, Thomas (Airway Research Center North (ARCN). Members of the Germany Center for Lung Research (DZL)) ;
Rabe, Klaus F. (Airway Research Center North (ARCN). Members of the Germany Center for Lung Research (DZL)) ;
Hansen, Gesine (Department of Pediatric Pneumology. Allergology and Neonatology. Hannover Medical School) ;
Kopp, Matthias V. (Department of Paediatric Respiratory Medicine. Inselspital. University Children's Hospital of Bern. University of Bern) ;
Rios, Raimon (Programa de Pós Graduação em Imunologia (PPGIm). Instituto de Ciências da Saúde. Universidade Federal da Bahia (UFBA)) ;
Cruz, Maria Jesús (Hospital Universitari Vall d'Hebron) ;
González-Barcala, Francisco Javier (Complejo Hospitalario Universitario de Santiago de Compostela. Servicio de Neumología) ;
Olaguibel, José María (Complejo Hospitalario de Navarra) ;
Plaza, Vicente (Institut d'Investigació Biomèdica Sant Pau) ;
Quirce Gancedo, Santiago (Hospital Universitario La Paz. Instituto de Investigación Hospital Universitario La Paz. Servicio de Alergología) ;
Canino, Glorisa (Behavioral Sciences Research Institute. University of Puerto Rico) ;
Cloutier, Michelle (Department of Pediatrics. University of Connecticut) ;
Del Pozo, Victoria (Instituto de Investigación Sanitaria Hospital Universitario Fundación Jiménez Díaz. Servicio de Inmunología) ;
Rodriguez-Santana, Jose R. (Centro de Neumología Pediátrica) ;
Korta-Murua, Javier (Universidad del País Vasco. Departamento de Pediatría) ;
Villar, Jesús (Hospital Universitario de Gran Canaria Doctor Negrín. Multidisciplinary Organ Dysfunction Evaluation Research Network. Research Unit) ;
Potočnik, Uros (Laboratory for Biochemistry. Molecular Biology and Genomics. Faculty for Chemistry and Chemical Engineering. University of Maribor) ;
Figueiredo, Camila (Instituto de Ciências da Saúde. Universidade Federal da Bahia) ;
Kabesch, Michael (Department of Paediatric Pneumology and Allergy. University Children's Hospital Regensburg (KUNO)) ;
Mukhopadhyay, Somnath (Population Pharmacogenetics Group. Biomedical Research Institute. Ninewells Hospital and Medical School. University of Dundee) ;
Pirmohamed, Munir (Department of Pharmacology and Therapeutics. Institute of Systems. Molecular and Integrative Biology. University of Liverpool) ;
Hawcutt, Daniel (NIHR Alder Hey Clinical Research Facility. Alder Hey Children's Hospital) ;
Melén, Erik (Sachs' Children's Hospital. South General Hospital) ;
Palmer, Colin (Population Pharmacogenetics Group. Biomedical Research Institute. Ninewells Hospital and Medical School. University of Dundee) ;
Turner, Steve (Child Health. University of Aberdeen) ;
Maitland-van der Zee, Anke H. (Department of Paediatric Respiratory Medicine and Allergy. Emma's Children Hospital. Amsterdam UMC. University of Amsterdam) ;
von Mutius, Erika (Comprehensive Pneumology Center Munich (CPC-M). Member of the German Center for Lung Research) ;
Celedón, Juan C. (Division of Pediatric Pulmonary Medicine. UPMC Children's Hospital of Pittsburgh. University of Pittsburgh) ;
Brusselle, Guy (Department of Respiratory Medicine. Erasmus University Medical Center) ;
Chew, Fook Tim (Department of Biological Sciences. National University of Singapore) ;
Bleecker, Eugene (Division of Genetics. Genomics. and Precision Medicine. Department of Internal Medicine. University of Arizona College of Medicine) ;
Meyers, Deborah (Division of Genetics. Genomics. and Precision Medicine. Department of Internal Medicine. University of Arizona College of Medicine) ;
Burchard, Esteban G. (Department of Bioengineering and Therapeutic Sciences. University of California San Francisco) ;
Pino-Yanes, Maria (Universidad de la Laguna. Instituto de Tecnologías Biomédicas)
Background: Asthma exacerbations are a serious public health concern due to high healthcare resource utilization, work/school productivity loss, impact on quality of life, and risk of mortality. The genetic basis of asthma exacerbations has been studied in several populations, but no prior study has performed a multi-ancestry meta-analysis of genome-wide association studies (meta-GWAS) for this trait. [...]
2022 - 10.1111/pai.13802
Pediatric Allergy and Immunology, Vol. 33 Núm. 6 (june 2022) , p. e13802
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