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12 p, 2.0 MB |
Ultrasensitive label-free detection of unamplified multidrug-resistance bacteria genes with a bimodal waveguide interferometric biosensor
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Maldonado, Jesús (Institut Català de Nanociència i Nanotecnologia) ;
González-Guerrero, Ana Belén (Institut Català de Nanociència i Nanotecnologia) ;
Fernández Gavela, Adrián (Institut Català de Nanociència i Nanotecnologia) ;
González, Juan José (Universitat Autònoma de Barcelona. Departament de Genètica i Microbiologia) ;
Lechuga, Laura (Institut Català de Nanociència i Nanotecnologia)
Infections by multidrug-resistant bacteria are becoming a major healthcare emergence with millions of reported cases every year and an increasing incidence of deaths. An advanced diagnostic platform able to directly detect and identify antimicrobial resistance in a faster way than conventional techniques could help in the adoption of early and accurate therapeutic interventions, limiting the actual negative impact on patient outcomes. [...]
2020 -  10.3390/diagnostics10100845
Diagnostics, Vol. 10, issue 10 (Oct. 2020) , art. 845
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20 p, 1.1 MB |
Label-free detection of nosocomial bacteria using a nanophotonic interferometric biosensor
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Maldonado, Jesús (Institut Català de Nanociència i Nanotecnologia) ;
Estévez, M. Carmen (Institut Català de Nanociència i Nanotecnologia) ;
Fernández Gavela, Adrián (Institut Català de Nanociència i Nanotecnologia) ;
González López, Juan José (Hospital Universitari Vall d'Hebron) ;
González-Guerrero, Ana Belén (Institut Català de Nanociència i Nanotecnologia) ;
Lechuga, Laura (Institut Català de Nanociència i Nanotecnologia)
Nosocomial infections are a major concern at the worldwide level. Early and accurate identification of nosocomial pathogens is crucial to provide timely and adequate treatment. A prompt response also prevents the progression of the infection to life-threatening conditions, such as septicemia or generalized bloodstream infection. [...]
2020 - 10.1039/c9an01485c
Analyst, Vol. 145, Issue 2 (January 2020) , p. 497-506
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15 p, 4.4 MB |
Linear readout of integrated interferometric biosensors using a periodic wavelength modulation
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Dante, Stefania (Institut Català de Nanociència i Nanotecnologia) ;
Duval, Daphné (Institut Català de Nanociència i Nanotecnologia) ;
Fariña, David (Institut Català de Nanociència i Nanotecnologia) ;
González-Guerrero, Ana Belén (Institut Català de Nanociència i Nanotecnologia) ;
Lechuga, Laura (Institut Català de Nanociència i Nanotecnologia)
An all-optical phase modulation method for the linear readout of integrated interferometric biosensors is demonstrated, merging simple intensity detection with the advantages offered by spectral interrogation. [...]
2015 - 10.1002/lpor.201400216
Laser and photonics reviews, Vol. 9, Issue 2 (March 2015) , p. 248-255
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11 p, 910.6 KB |
Nanophotonic lab-on-a-chip platforms including novel bimodal interferometers, microfluidics and grating couplers
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Duval, Daphné (Institut Català de Nanociència i Nanotecnologia) ;
González-Guerrero, Ana Belén (Institut Català de Nanociència i Nanotecnologia) ;
Dante, Stefania (Institut Català de Nanociència i Nanotecnologia) ;
Osmond, Johann (Institute of Photonic Sciences) ;
Monge, Rosa (Universidad de Zaragoza) ;
Fernández, Luis J. (Universidad de Zaragoza) ;
Zinoviev, K.E. (Microelectronics National Center) ;
Domínguez Horna, Carlos (Microelectronics National Center) ;
Lechuga, Laura (Institut Català de Nanociència i Nanotecnologia)
One of the main limitations for achieving truly lab-on-a-chip (LOC) devices for point-of-care diagnosis is the incorporation of the "on-chip" detection. Indeed, most of the state-of-the-art LOC devices usually require complex read-out instrumentation, losing the main advantages of portability and simplicity. [...]
2012 - 10.1039/c2lc40054e
Lab on a chip, Vol. 12, Issue 11 (May 2012) , p. 1987-1994
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9 p, 1.1 MB |
A low-cost integrated biosensing platform based on SiN nanophotonics for biomarker detection in urine
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Martens, Daan (Ghent University) ;
Ramírez Priego, Patricia (Institut Català de Nanociència i Nanotecnologia) ;
Murib, M.S. (Ghent University) ;
Elamin, Ayssar A. (LIONEX Diagnostics and Therapeutics GmbH) ;
González-Guerrero, Ana Belén (Institut Català de Nanociència i Nanotecnologia) ;
Stehr, M. (LIONEX Diagnostics and Therapeutics GmbH) ;
Jonas, F. (LIONEX Diagnostics and Therapeutics GmbH) ;
Anton, Birgit (Microfluidic ChipShop GmbH) ;
Hlawatsch, N. (Microfluidic ChipShop GmbH) ;
Soetaert, Pieterjan (Trinean NV) ;
Vos, Rita (Imec) ;
Stassen, A. (Imec) ;
Severi, S. (Imec) ;
Van Roy, Wim (Imec) ;
Bockstaele, Ronny (Trinean NV) ;
Becker, Holger (Microfluidic ChipShop GmbH) ;
Singh, M. (LIONEX Diagnostics and Therapeutics GmbH) ;
Lechuga, Laura (Institut Català de Nanociència i Nanotecnologia) ;
Bienstman, Peter (Ghent University)
We present a low-cost integrated nanophotonic lab-on-a-chip platform suitable for point-of-care (POC) biomarker analysis. The sensor chip included in the platform contains multiplexed Mach-Zehnder interferometers with an on-chip optical spectral analyser consisting of an arrayed-waveguide grating. [...]
2018 - 10.1039/c8ay00666k
Analytical methods, Vol. 10, Issue 25 (July 2018) , p. 3066-3073
2 documents
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16 p, 406.9 KB |
Direct and label-free detection of the human growth hormone in urine by an ultrasensitive bimodal waveguide biosensor
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González-Guerrero, Ana Belén (Institut Català de Nanociència i Nanotecnologia) ;
Maldonado, Jesús (Institut Català de Nanociència i Nanotecnologia) ;
Dante, Stefania (Institut Català de Nanociència i Nanotecnologia) ;
Grajales García, Daniel (Institut Català de Nanociència i Nanotecnologia) ;
Lechuga, Laura (Institut Català de Nanociència i Nanotecnologia)
A label-free interferometric transducer showing a theoretical detection limit for homogeneous sensing of 5 × 10⁻⁸ RIU, being equivalent to a protein mass coverage resolution of 2. 8 fg mm⁻², is used to develop a high sensitive biosensor for protein detection. [...]
2017 - 10.1002/jbio.201600154
Journal of biophotonics, Vol. 10, issue 1 (Jan. 2017) , p. 61-67
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