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13 p, 1.8 MB Ligand chain length drives activation of lipid G protein-coupled receptors / Troupiotis-Tsaïlaki, Anastassia (Université Libre de Bruxelles. Laboratoire de Structure et Fonction des Membranes Biologiques) ; Zachmann, Julian (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional) ; González-Gil, Inés (Universidad Complutense de Madrid. Departamento de Química Orgánica I) ; González, Ángel (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional) ; Ortega Gutiérrez, Silvia (Universidad Complutense de Madrid. Departamento de Química Orgánica I) ; López-Rodríguez, María L. (Universidad Complutense de Madrid. Departamento de Química Orgánica I) ; Pardo Carrasco, Leonardo (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional) ; Govaerts, Cedric (Université Libre de Bruxelles. Laboratoire de Structure et Fonction des Membranes Biologiques)
Sphingosine-1-phosphate (S1P) is a lipid mediator that can activate five cell membrane G proteincoupled receptors (GPCRs) which carry a variety of essential functions and are promising drug targets. S1P is composed of a polar zwitterionic head-group and a hydrophobic alkyl chain. [...]
2017 - 10.1038/s41598-017-02104-5
Scientific Reports, Vol. 7 (2017) , art. 2020  

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