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8 p, 1.3 MB |
Impact of ceftolozane/tazobactam concentrations in continuous infusion against extensively drug-resistant Pseudomonas aeruginosa isolates in a hollow-fiber infection model
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Montero, María M. (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Domene-Ochoa, Sandra (Institut Hospital del Mar d'Investigacions Mèdiques) ;
López-Causapé, Carla (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Luque, Sonia (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Sorlí, Luisa (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Campillo, Núria (Hospital del Mar (Barcelona, Catalunya)) ;
Padilla León, Eduardo (Laboratori de Referència de Catalunya (El Prat de Llobregat, Catalunya)) ;
Prim, Núria (Laboratori de Referència de Catalunya (El Prat de Llobregat, Catalunya)) ;
Ferrer-Alapont, Lorena (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Angulo-Brunet, Ariadna (Universitat Oberta de Catalunya) ;
Grau, Santiago (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Oliver, Antonio (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Horcajada, Juan Pablo (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Universitat Autònoma de Barcelona
Ceftolozane/tazobactam (C/T) has emerged as a potential agent for the treatment of extensively drug-resistant (XDR) Pseudomonas aeruginosa infections. As it is a time-dependent antimicrobial, prolonged infusion may help achieve pharmacokinetic/pharmacodynamic (PK/PD) targets. [...]
2021 -  10.1038/s41598-021-01784-4
Scientific reports, Vol. 11 (november 2021)
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9 p, 884.2 KB |
Comparison of Ceftolozane/Tazobactam Infusion Regimens in a Hollow-Fiber Infection Model against Extensively Drug-Resistant Isolates
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Montero, María Milagro (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Domene-Ochoa, Sandra (Institut Hospital del Mar d'Investigacions Mèdiques) ;
López-Causapé, Carla ;
López Montesinos, Inmaculada (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Luque, Sonia (Hospital del Mar (Barcelona, Catalunya)) ;
Sorlí, Luisa (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Campillo, Núria (Hospital del Mar (Barcelona, Catalunya)) ;
Padilla León, Eduardo ;
Prim, Núria ;
Ferrer Alapont, Lorena (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Grau, Santiago (Hospital del Mar (Barcelona, Catalunya)) ;
Oliver, Antonio ;
Horcajada, Juan Pablo (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Universitat Autònoma de Barcelona
The aim of this study was to compare the efficacy of intermittent (1-h), extended (4-h), and continuous ceftolozane-tazobactam (C/T) infusion against three extensively drug-resistant (XDR) sequence type (ST) 175 isolates with different susceptibilities to C/T (MIC = 2 to 16 mg/L) in a 7-day hollow-fiber infection model (HFIM). [...]
2022 - 10.1128/spectrum.00892-22
Microbiology Spectrum, Vol. 10 (june 2022)
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3.
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26 p, 1.8 MB |
Clinical Guideline on Perioperative Management of Patients with Advanced Chronic Liver Disease
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Canillas, Lidia (Hospital del Mar (Barcelona, Catalunya)) ;
Pelegrina, Amalia (Hospital del Mar (Barcelona, Catalunya)) ;
Álvarez, Juan (Hospital del Mar (Barcelona, Catalunya)) ;
Colominas-González, Elena (Hospital del Mar (Barcelona, Catalunya)) ;
Salar, Antonio (Hospital del Mar (Barcelona, Catalunya)) ;
Aguilera, Lluís G. (Hospital del Mar (Barcelona, Catalunya)) ;
Burdío, Fernando (Hospital del Mar (Barcelona, Catalunya)) ;
Montes, Antonio (Hospital del Mar (Barcelona, Catalunya)) ;
Grau, Santiago (Hospital del Mar (Barcelona, Catalunya)) ;
Grande, L (Hospital del Mar (Barcelona, Catalunya)) ;
Carrión Rodríguez, José Antonio (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Universitat Autònoma de Barcelona
Patients with advanced chronic liver disease (ACLD) are living longer with more comorbidities because of improved medical and surgical management. However, patients with ACLD are at increased risk of perioperative morbidity and mortality; We conducted a comprehensive review of the literature to support a narrative clinical guideline about the assessment of mortality risk and management of perioperative morbidity in patients with ACLD undergoing surgical procedures; Slight data exist to guide the perioperative management of patients with ACLD, and most recommendations are based on case series and expert opinion. [...]
2023 - 10.3390/life13010132
Life, Vol. 13 (january 2023)
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12 p, 1.1 MB |
Real-world effectiveness and persistence of reference etanercept versus biosimilar etanercept GP2015 among rheumatoid arthritis patients : A cohort study
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Carballo, Nuria (Universitat Autònoma de Barcelona) ;
Pérez García, Carolina (Parc de Salut MAR de Barcelona) ;
Grau, Santiago (Universitat Autònoma de Barcelona) ;
Monfort, Jordi (Parc de Salut MAR de Barcelona) ;
Duran-Jordà, Xavier (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Echeverría-Esnal, Daniel (Parc de Salut MAR de Barcelona) ;
Ferrández, Olivia (Universitat Autònoma de Barcelona)
Although several randomized clinical trials have confirmed that there is no difference in efficacy between etanercept and its biosimilar versions in the treatment of rheumatoid arthritis (RA), limited real-world evidence is available. [...]
2022 - 10.3389/fphar.2022.980832
Frontiers in Pharmacology, Vol. 13 (october 2022)
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1 p, 505.3 KB |
Corrigendum : Impact of Non-Persistence on Healthcare Resource Utilization Costs in Patients With Immune-Mediated Rheumatic Diseases Initiating Subcutaneous TNF-Alpha Inhibitors: A Before-and-After Study
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Carballo, Nuria (Universitat Autònoma de Barcelona) ;
Garcia-Alzórriz, Enric (Parc de Salut MAR de Barcelona) ;
Ferrández, Olivia (Universitat Autònoma de Barcelona) ;
Navarrete-Rouco, Maria Eugenia (Parc de Salut MAR de Barcelona) ;
Duran-Jordà, Xavier (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Pérez-García, Carolina (Hospital del Mar (Barcelona, Catalunya)) ;
Monfort, Jordi (Hospital del Mar (Barcelona, Catalunya)) ;
Cots Reguant, Francesc (Parc de Salut MAR de Barcelona) ;
Grau, Santiago (Universitat Autònoma de Barcelona)
2022 - 10.3389/fphar.2022.867017
Frontiers in Pharmacology, Vol. 13 (march 2022)
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5 p, 226.8 KB |
Impact of changes in the WHO's 2019 update of DDDs on the measurement of adult hospital antibacterial consumption in Catalonia (Spain), 2008-18
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Grau, Santiago (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Hernández Baeza, Sergi (VINCat Vigilància de les infeccions nosocomials als hospitals de Catalunya) ;
Limón, Enric (VINCat Vigilància de les infeccions nosocomials als hospitals de Catalunya) ;
Calbo Sebastián, Esther (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Horcajada, Juan Pablo (Hospital del Mar (Barcelona, Catalunya)) ;
Universitat Autònoma de Barcelona
In 2019 the WHO fully adopted new DDD values. The objective of this study is to analyse their impact on the measurement of consumption of antibacterials in hospitals participating in the Catalan Infection Control and Antimicrobial Stewardship National Program (VINCat-PROA) in Catalonia (Spain) between 2008 and 2018. [...]
2020 - 10.1093/jacamr/dlaa079
JAC-Antimicrobial Resistance, Vol. 2 (october 2020)
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10 p, 696.8 KB |
Pharmacokinetics and Pharmacodynamics of Meropenem by Extended or Continuous Infusion in Low Body Weight Critically Ill Patients
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Luque, Sonia (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Benítez-Cano, Adela (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Larrañaga, Leire (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Sorlí, Luisa (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Navarrete-Rouco, Maria Eugenia (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Campillo, Núria (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Carazo, Jesús (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Ramos, Isabel (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Adalia, Ramón (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Grau, Santiago (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Universitat Autònoma de Barcelona
Background : Pathophysiological changes such as extreme body weights in critically ill patients with severe infections may alter the pharmacokinetics (PK) of antimicrobials, leading to treatment failure or toxicity. [...]
2021 - 10.3390/antibiotics10060666
Antibiotics, Vol. 10 (june 2021)
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13 p, 556.7 KB |
Daptomycin versus Glycopeptides for the Treatment of Enterococcus faecium Bacteraemia : A Cohort Study
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Echeverría-Esnal, Daniel (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Sorlí, Luisa (Hospital del Mar (Barcelona, Catalunya)) ;
Prim, Núria (Laboratori de Referència de Catalunya (Barcelona)) ;
Martin-Ontiyuelo, Clara (Hospital del Mar (Barcelona, Catalunya)) ;
Horcajada, Juan Pablo (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Grau, Santiago (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Background: Ampicillin resistant and glycopeptide susceptible Enterococcus faecium bloodstream infection (GSEF-BSI) incidence has risen. However, the treatment of choice remains unknown. Daptomycin use for the treatment of enterococcal infections has increased, despite effectiveness and safety concerns. [...]
2021 - 10.3390/antibiotics10060716
Antibiotics, Vol. 10 (june 2021)
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11 p, 264.6 KB |
Risk Factors for Amoxicillin-Clavulanate Resistance in Community-Onset Urinary Tract Infections Caused by Escherichia coli or Klebsiella pneumoniae : The Role of Prior Exposure to Fluoroquinolones
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Martínez-Casanova, Javier (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Gómez-Zorrilla, Silvia (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Prim, Núria (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Dal Molin, Agustina (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Echeverría-Esnal, Daniel (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Gracia-Arnillas, María Pilar (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Sendra, Elena (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Güerri-Fernández, Robert (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Duran-Jordà, Xavier (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Padilla León, Eduardo (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Horcajada, Juan Pablo (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Grau, Santiago (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Universitat Autònoma de Barcelona
Background: High rates of amoxicillin-clavulanate (AMC) resistance among Enterobacterales isolated from urinary tract infections (UTIs) were observed in our area. The aim of this study was to identify risk factors associated with AMC resistance in patients with community-onset UTI in emergency departments (EDs). [...]
2021 - 10.3390/antibiotics10050582
Antibiotics, Vol. 10 (may 2021)
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10 p, 237.9 KB |
Clinical and Economic Impact of Community-Onset Urinary Tract Infections Caused by ESBL-Producing Klebsiella pneumoniae Requiring Hospitalization in Spain : An Observational Cohort Study
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Rozenkiewicz, Dawid (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Esteve-Palau, Erika (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Arenas-Miras, Maria del Mar (Instituto de Salud Carlos III) ;
Grau, Santiago (Hospital del Mar (Barcelona, Catalunya)) ;
Duran-Jordà, Xavier (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Sorlí, Luisa (Instituto de Salud Carlos III) ;
Montero, María Milagro (Instituto de Salud Carlos III) ;
Horcajada, Juan Pablo (Instituto de Salud Carlos III) ;
Universitat Autònoma de Barcelona
Objective : To analyze the clinical and economic impact of community-onset urinary tract infections (UTIs) caused by extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae requiring hospitalization. [...]
2021 - 10.3390/antibiotics10050585
Antibiotics, Vol. 10 (may 2021)
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