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Cell internalization in fluidic culture conditions is improved when microparticles are specifically targeted to the human epidermal growth factor receptor 2 (Her2) / Mora Espí, Inmaculada (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Ibáñez, Elena (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Soriano Martín, Jorge (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Nogués, C. (Carme) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Gudjonsson, Thorarinn (University of Iceland. Biomedical Center) ; Barrios, Leonardo (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Purpose: To determine if the specific targeting of microparticles improves their internalization by cells under fluidic conditions. Methods: Two isogenic breast epithelial cell lines, one overexpressing the Human Epidermal Growth Factor Receptor 2 (HER2) oncogene (D492HER2) and highly tumorigenic and the other expressing HER2 at much lower levels and non-tumorigenic (D492), were cultured in the presence of polystyrene microparticles of 1 _m in diameter, biofunctionalized with either a specific anti-HER2 antibody or a non-specific secondary antibody. [...]
2019 - DOI (Digital Object Identifier)

10.3390/pharmaceutics11040177
Pharmaceutics, Vol. 11, Issue 4 (April 2019) , art. 177

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See also: similar author names
1	Gudjonsson, T.
1	Gudjónsson, T.

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