Results overview: Found 4 records in 0.02 seconds.
Articles, 4 records found
Articles 4 records found  
1.
14 p, 1.2 MB Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology / Suárez Calvet, Marc (Ludwig Maximilians Universität München) ; Morenas Rodríguez, Estrella (Institut d'Investigació Biomèdica Sant Pau) ; Kleinberger, Gernot (Ludwig Maximilians Universität München) ; Schlepckow, Kai (German Center for Neurodegenerative Diseases (DZNE) Munich) ; Araque Caballero, Miguel Ángel (Ludwig Maximilians Universität München) ; Franzmeier, Nicolai (Ludwig Maximilians Universität München) ; Capell, Anja (Ludwig Maximilians Universität München) ; Fellerer, Katrin (Ludwig Maximilians Universität München) ; Nuscher, Brigitte (Ludwig Maximilians Universität München) ; Eren, Erden (Ludwig Maximilians Universität München) ; Levin, Johannes (German Center for Neurodegenerative Diseases (DZNE) Munich) ; Deming, Yuetiva (Washington University School of Medicine) ; Piccio, Laura (Washington University School of Medicine) ; Karch, Celeste M. (Washington University School of Medicine) ; Cruchaga, Carlos (Washington University School of Medicine) ; Shaw, Leslie M. (University of Pennsylvania) ; Trojanowski, John Q. (University of Pennsylvania) ; Weiner, Michael (University of California at San Francisco) ; Ewers, Michael (Ludwig Maximilians Universität München) ; Haass, Christian (Ludwig Maximilians Universität München) ; Universitat Autònoma de Barcelona
TREM2 is a transmembrane receptor that is predominantly expressed by microglia in the central nervous system. Rare variants in the TREM2 gene increase the risk for late-onset Alzheimer's disease (AD). [...]
2019 - 10.1186/s13024-018-0301-5
Molecular neurodegeneration, Vol. 14 (january 2019)  
2.
21 p, 965.2 KB CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline / Suárez-Calvet, Marc (Ludwig Maximilians Universität München) ; Capell, Anja (Ludwig Maximilians Universität München) ; Araque Caballero, Miguel Ángel (Ludwig Maximilians Universität München) ; Morenas-Rodríguez, Estrella (Universitat Autònoma de Barcelona) ; Fellerer, Katrin (Ludwig Maximilians Universität München) ; Franzmeier, Nicolai (Ludwig Maximilians Universität München) ; Kleinberger, Gernot (Munich Cluster for Systems Neurology (SyNergy)) ; Eren, Erden (Dokuz Eylul University, Turkey) ; Deming, Yuetiva (Washington University School of Medicine) ; Piccio, Laura (Washington University School of Medicine) ; Karch, Celeste M (Washington University School of Medicine) ; Cruchaga, Carlos (Washington University School of Medicine) ; Paumier, Katrina (Washington University School of Medicine) ; Bateman, Randall J (Washington University School of Medicine) ; Fagan, Anne M (Washington University School of Medicine) ; Morris, John C (Washington University School of Medicine) ; Levin, Johannes (Ludwig Maximilians Universität München) ; Danek, Adrian (Ludwig Maximilians Universität München) ; Jucker, Mathias (University of Tübingen) ; Masters, Colin L (University of Melbourne) ; Rossor, Martin N (UCL Institute of Neurology) ; Ringman, John M (University of Southern California) ; Shaw, Leslie M (University of Pennsylvania) ; Trojanowski, John Q (University of Pennsylvania) ; Weiner, Michael (University of California at San Francisco) ; Ewers, Michael (Ludwig Maximilians Universität München) ; Haass, Christian (Munich Cluster for Systems Neurology (SyNergy))
Progranulin (PGRN) is predominantly expressed by microglia in the brain, and genetic and experimental evidence suggests a critical role in Alzheimer's disease (AD). We asked whether expression is changed in a disease severity-specific manner in . [...]
2018 - 10.15252/emmm.201809712
EMBO Molecular Medicine, Vol. 10 (november 2018)  
3.
10 p, 838.9 KB The APOE ε4 genotype modulates CSF YKL-40 levels and their structural brain correlates in the continuum of Alzheimer's disease but not those of sTREM2 / Gispert, Juan Domingo (Universitat Pompeu Fabra) ; Monté, Gemma C. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Suárez-Calvet, Marc (German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany) ; Falcon, Carles (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Zaragoza, Spain) ; Tucholka, Alan (Barcelonaβeta Brain Research Center (BBRC)) ; Rojas, Santiago (Universitat Autònoma de Barcelona. Departament de Ciències Morfològiques) ; Rami, Lorena (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Sánchez-Valle, Raquel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Lladó, Albert (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Kleinberger, Gernot (Munich Cluster for Systems Neurology (SyNergy), Munich, Germany) ; Haass, Christian (Munich Cluster for Systems Neurology (SyNergy), Munich, Germany) ; Molinuevo, José Luis (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Among other metabolic functions, the apolipoprotein E (APOE) plays a crucial role in neuroinflammation. We aimed at assessing whether APOE ε4 modulates levels of glial cerebrospinal fluid (CSF) biomarkers and their structural cerebral correlates along the continuum of Alzheimer's disease (AD). [...]
2016 - 10.1016/j.dadm.2016.12.002
Alzheimer's & dementia, Vol. 6 (december 2016) , p. 50-59  
4.
11 p, 519.1 KB 2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers / Suárez-Calvet, Marc (German Center for Neurodegenerative Diseases (DZNE) Munich) ; Kleinberger, Gernot (Munich Cluster for Systems Neurology (SyNergy)) ; Araque Caballero, Miguel Ángel (Ludwig-Maximilians-University Munich) ; Brendel, Matthias (Ludwig-Maximilians-University Munich) ; Rominger, Axel (Ludwig-Maximilians-University Munich) ; Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ; Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ; Gispert, Juan Domingo (Institut d'Investigació Biomèdica Sant Pau) ; Sánchez-Valle, Raquel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Antonell, Anna (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Rami, Lorena (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Molinuevo, José L (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Brosseron, Frederic (German Center for Neurodegenerative Diseases (DZNE)) ; Traschütz, Andreas (Universitätsklinikum Bonn) ; Heneka, Michael T (Universitätsklinikum Bonn) ; Struyfs, Hanne (Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken) ; Engelborghs, Sebastiaan (Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken) ; Sleegers, Kristel (University of Antwerp. Institute Born-Bunge) ; Van Broeckhoven, Christine (University of Antwerp. Institute Born-Bunge) ; Zetterberg, Henrik (UCL Institute of Neurology) ; Nellgård, Bengt (Gothenburg University. Sahlgrenska Academy. Institute of Clinical Sciences) ; Blennow, Kaj (The Sahlgrenska Academy at the University of Gothenburg. Institute of Neuroscience and Physiology) ; Crispin, Alexander (Institute of Medical Informatics, Biometry, and Epidemiology) ; Ewers, Michael (Ludwig-Maximilians-University Munich) ; Haass, Christian (BioMedical Center (BMC), Biochemistry, Ludwig-Maximilians-University Munich) ; Universitat Autònoma de Barcelona
2 is an innate immune receptor expressed on the surface of microglia. Loss-of-function mutations of 2 are associated with increased risk of Alzheimer's disease (). 2 is a type-1 protein with an ectodomain that is proteolytically cleaved and released into the extracellular space as a soluble variant (2), which can be measured in the cerebrospinal fluid (). [...]
2016 - 10.15252/emmm.201506123
EMBO Molecular Medicine, Vol. 8 (march 2016) , p. 466-476  

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2 Haass, C.
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