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Artículos Encontrados 3 registros  
1.
9 p, 1.7 MB KRAS and BRAF mutations in circulating tumour DNA from locally advanced rectal cancer / Sclafani, Francesco (The Royal Marsden NHS Foundation Trust) ; Chau, Ian (The Royal Marsden NHS Foundation Trust) ; Cunningham, David (The Royal Marsden NHS Foundation Trust) ; Hahne, Jens Claus (The Institute of Cancer Research) ; Vlachogiannis, George (The Institute of Cancer Research) ; Eltahir, Zakaria (The Royal Marsden NHS Foundation Trust) ; Lampis, Andrea (The Institute of Cancer Research) ; Braconi, Chiara (The Institute of Cancer Research) ; Kalaitzaki, Eleftheria (The Royal Marsden NHS Foundation Trust) ; De Castro, David Gonzalez (The Royal Marsden NHS Foundation Trust) ; Wotherspoon, Andrew (The Royal Marsden NHS Foundation Trust) ; Capdevila Castillón, Jaume (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Glimelius, Bengt (University of Uppsala) ; Tarazona, Noelia (Universitat de València) ; Begum, Ruwaida (The Royal Marsden NHS Foundation Trust) ; Lote, Hazel (The Institute of Cancer Research) ; Hulkki Wilson, Sanna (The Royal Marsden NHS Foundation Trust) ; Mentrasti, Giulia (The Institute of Cancer Research) ; Brown, Gina (The Royal Marsden NHS Foundation Trust) ; Tait, Diana (The Royal Marsden NHS Foundation Trust) ; Oates, Jacqueline (The Royal Marsden NHS Foundation Trust) ; Valeri, Nicola (The Institute of Cancer Research) ; Universitat Autònoma de Barcelona
There are limited data on circulating, cell-free, tumour (ct)DNA analysis in locally advanced rectal cancer (LARC). Digital droplet (dd)PCR was used to investigate KRAS/BRAF mutations in ctDNA from baseline blood samples of 97 LARC patients who were treated with CAPOX followed by chemoradiotherapy, surgery and adjuvant CAPOX ± cetuximab in a randomised phase II trial. [...]
2018 - 10.1038/s41598-018-19212-5
Scientific reports, Vol. 8 (january 2018)  
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2.
6 p, 1.4 MB Sequence variation in mature microRNA-608 and benefit from neo-adjuvant treatment in locally advanced rectal cancer patients / Sclafani, Francesco (The Royal Marsden NHS Foundation Trust. Department of Medicine) ; Chau, Ian (The Royal Marsden NHS Foundation Trust. Department of Medicine) ; Cunningham, David (The Royal Marsden NHS Foundation Trust. Department of Medicine) ; Lampis, Andrea (The Institute of Cancer Research. Department of Molecular Pathology) ; Hahne, Jens Claus (The Institute of Cancer Research. Department of Molecular Pathology) ; Ghidini, Michele (The Institute of Cancer Research. Department of Molecular Pathology) ; Lote, Hazel (The Institute of Cancer Research. Department of Molecular Pathology) ; Zito, Domenico (The Institute of Cancer Research. Department of Molecular Pathology) ; Tabernero, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Glimelius, Bengt (University of Uppsala. Genetics and Pathology, Experimental and Clinical Oncology. Department of Immunology) ; Cervantes, Andrés (University of Valencia. Biomedical Research Institute INCLIVA. Department of Haematology and Medical Oncology) ; Begum, Ruwaida (The Royal Marsden NHS Foundation Trust. Department of Medicine) ; De Castro, David Gonzalez (The Royal Marsden NHS Foundation Trust. Department of Medicine) ; Wilson, Sanna Hulkki (The Royal Marsden NHS Foundation Trust. Department of Medicine) ; Peckitt, Clare (The Royal Marsden NHS Foundation Trust. Department of Medicine) ; Eltahir, Zakaria (The Royal Marsden NHS Foundation Trust. Department of Medicine) ; Wotherspoon, Andrew (The Royal Marsden NHS Foundation Trust. Department of Medicine) ; Tait, Diana (The Royal Marsden NHS Foundation Trust. Department of Medicine) ; Brown, Gina (The Royal Marsden NHS Foundation Trust. Department of Medicine) ; Oates, Jacqueline (The Royal Marsden NHS Foundation Trust. Department of Medicine) ; Braconi, Chiara (The Institute of Cancer Research. Department of Cancer Therapeutics) ; Valeri, Nicola (The Institute of Cancer Research. Department of Molecular Pathology) ; Universitat Autònoma de Barcelona
Analysis of a polymorphism in mature microRNA-608 (rs4919510) in rectal cancer patients enrolled in a randomized phase II clinical trial identified patient subpopulations who might benefit from the use of an intensified neo-adjuvant treatment strategy with Cetuximab. [...]
2016 - 10.1093/carcin/bgw073
Carcinogenesis, Vol. 37 (july 2016) , p. 852-857  
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3.
6 p, 225.1 KB Prognostic role of the LCS6 KRAS variant in locally advanced rectal cancer : results of the EXPERT-C trial / Sclafani, Francesco (The Royal Marsden NHS Foundation Trust. Department of Medicine (UK)) ; Chau, Ian (The Royal Marsden NHS Foundation Trust. Department of Medicine (UK)) ; Cunningham, David (The Royal Marsden NHS Foundation Trust. Department of Medicine (UK)) ; Peckitt, C. (The Royal Marsden NHS Foundation Trust. Department of Medicine (UK)) ; Lampis, Andrea (The Institute of Cancer Research. Division of Molecular Pathology (UK)) ; Hahne, Jens Claus (The Institute of Cancer Research. Division of Molecular Pathology (UK)) ; Braconi, Chiara (The Institute of Cancer Research. Division of Cancer Therapeutics (UK)) ; Tabernero, Josep (Hospital Universitari Vall d'Hebron) ; Glimelius, B. (University of Uppsala. Department of Immunology, Genetics and Pathology (Sweden)) ; Cervantes, Andrés (Universitat de València. Departament d'Hematologia i Oncologia Mèdica) ; Begum, Ruwaida (The Royal Marsden NHS Foundation Trust. Department of Medicine (UK)) ; González De Castro, David (The Royal Marsden NHS Foundation Trust. Department of Medicine (UK)) ; Hulkki Wilson, Sanna (The Royal Marsden NHS Foundation Trust. Department of Medicine (UK)) ; Eltahir, Zakaria (The Royal Marsden NHS Foundation Trust. Department of Medicine (UK)) ; Wotherspoon, Andrew (The Royal Marsden NHS Foundation Trust. Department of Medicine (UK)) ; Tait, D. (The Royal Marsden NHS Foundation Trust. Department of Medicine (UK)) ; Brown, Gina (The Royal Marsden NHS Foundation Trust. Department of Medicine (UK)) ; Oates, J. (The Royal Marsden NHS Foundation Trust. Department of Medicine (UK)) ; Valeri, Nicola (The Institute of Cancer Research. Division of Molecular Pathology (UK)) ; Universitat Autònoma de Barcelona
Lethal-7 (let-7) is a tumour suppressor miRNA which acts by down-regulating several oncogenes including KRAS. A single-nucleotide polymorphism (rs61764370, T > G base substitution) in the let-7 complementary site 6 (LCS-6) of KRAS mRNA has been shown to predict prognosis in early-stage colorectal cancer (CRC) and benefit from anti-epidermal growth factor receptor monoclonal antibodies in metastatic CRC. [...]
2015 - 10.1093/annonc/mdv285
Annals of oncology, Vol. 26, Issue 9 (September 2015) , p. 1936-1941  
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3 Hahne, Jens Claus
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