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14 p, 1.9 MB |
Safety, efficacy, and pharmacokinetics of gremubamab (MEDI3902), an anti-Pseudomonas aeruginosa bispecific human monoclonal antibody, in P. aeruginosa-colonised, mechanically ventilated intensive care unit patients : a randomised controlled trial
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Chastre, Jean (Service de Médecine Intensive Réanimation. Institut de Cardiologie. Groupe Hospitalier Pitié-Salpêtrière. Assistance Publique-Hôpitaux de Paris. Sorbonne University) ;
François, Bruno (Réanimation Polyvalente and Inserm CIC 1435 & UMR 1092. CHU) ;
Bourgeois, Marc (AZ Sint-Jan Brugge-Oostende AV) ;
Komnos, Apostolos (General Hospital of Larissa) ;
Ferrer, Ricard (Hospital Universitari Vall d'Hebron) ;
Rahav, Galia (Chaim Sheba Medical Center. Sackler School of Medicine. Tel Aviv University) ;
De Schryver, Nicolas (Clinique Saint-Pierre) ;
Lepape, Alain (Hospices Civils de Lyon Hôpital Lyon Sud) ;
Koksal, Iftihar (Faculty of Medicine. Trabzon and Acibadem University Faculty of Medicine. Karadeniz Technical University) ;
Luyt, Charles-Edouard (Service de Médecine Intensive Réanimation. Institut de Cardiologie. Groupe Hospitalier Pitié-Salpêtrière. Assistance Publique-Hôpitaux de Paris. Sorbonne University) ;
Sánchez-García, Miguel (Hospital Clínico San Carlos. Unidad de Cuidados Intensivos) ;
Torres, Antoni (Hospital Clínic i Provincial de Barcelona. Servei de Pneumologia) ;
Eggimann, Philippe (Department of Locomotor Apparatus. Centre Hospitalier Universitaire Vaudois CHUV) ;
Koulenti, Despoina (2nd Critical Care Department. Attikon University Hospital. National and Kapodistrian. University of Athens) ;
Holland, Thomas L. (Duke Clinical Research Institute) ;
Ali, Omar (Clinical Research and Development. Vaccines and Immune Therapies. BioPharmaceuticals R&D. AstraZeneca Biopharmaceuticals) ;
Shoemaker, Kathryn (Respiratory and Immunology. BioPharmaceuticals R&D. AstraZeneca) ;
Ren, Pin (Respiratory and Immunology. BioPharmaceuticals R&D. AstraZeneca) ;
Sauser, Julien (Infection Control Program. Faculty of Medicine. Geneva University Hospitals) ;
Ruzin, Alexey (Clinical Research and Development. Vaccines and Immune Therapies. BioPharmaceuticals R&D. AstraZeneca Biopharmaceuticals) ;
Tabor, David E. (Clinical Research and Development. Vaccines and Immune Therapies. BioPharmaceuticals R&D. AstraZeneca Biopharmaceuticals) ;
Akhgar, Ahmad (Clinical Pharmacology and Quantitative Pharmacology. Clinical Pharmacology and Safety Sciences. BioPharmaceuticals R&D. AstraZeneca) ;
Wu, Yuling (Clinical Pharmacology and Quantitative Pharmacology. Clinical Pharmacology and Safety Sciences. BioPharmaceuticals R&D. AstraZeneca) ;
Jiang, Yu (Clinical Pharmacology and Quantitative Pharmacology. Clinical Pharmacology and Safety Sciences. BioPharmaceuticals R&D. AstraZeneca) ;
DiGiandomenico, Antonio (Clinical Research and Development. Vaccines and Immune Therapies. BioPharmaceuticals R&D. AstraZeneca Biopharmaceuticals) ;
Colbert, Susan (Oncology. US SM&M. AstraZeneca) ;
Vandamme, Drieke (Inserm CIC 1435. CHU) ;
Coenjaerts, Frank (University Medical Center Utrecht) ;
Malhotra-Kumar, Surbhi (University of Antwerp. Laboratory of Medical Microbiology) ;
Timbermont, Leen (University of Antwerp. Laboratory of Medical Microbiology) ;
Oliver, Antonio (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Barraud, Olivier (INSERM U1092. Centre Hospitalier Universitaire de Limoges. Université Limoges) ;
Bellamy, Terramika (Clinical Research and Development. Vaccines and Immune Therapies. BioPharmaceuticals R&D. AstraZeneca Biopharmaceuticals) ;
Bonten, Marc (Julius Center for Health Science and Primary Care. University Medical Center Utrecht. Utrecht University) ;
Goossens, Herman (Laboratory of Medical Microbiology. Vaccine and Infectious Disease Institute. University of Antwerp) ;
Reisner, Colin (DevPro Biopharma) ;
Esser, Mark T. (Clinical Research and Development. Vaccines and Immune Therapies. BioPharmaceuticals R&D. AstraZeneca Biopharmaceuticals) ;
Jafri, Hasan S. (Late-Stage Development. Respiratory and Immunology. BioPharmaceuticals R&D. AstraZeneca) ;
Joannidis, Michael ;
Klimscha, Walter ;
De Waele, Elisabeth ;
Devriendt, Jacques ;
Huberlant, Vincent ;
Depuydt, Pieter ;
Van Boxstael, Sam ;
Peric, Mladen ;
Kopic, Jasminka ;
Hanauer, Michal ;
Hruby, Tomas ;
Sramek, Vladimir ;
Svoboda, Petr ;
Vymazal, Tomas ;
Novacek, Martin ;
Annane, Djillali ;
Mira, Jean-Paul ;
Souweine, Bertrand ;
Dequin, Pierre-François ;
Meziani, Ferhat ;
Stephan, François ;
Nseir, Saad ;
Gibot, Sebastien ;
Schwebel, Carole ;
Plantefeve, Gaetan ;
Diehl, Jean-Luc ;
Richard, Christian ;
Lamer, Christian ;
Klouche, Kada ;
Jaber, Samir ;
Zakynthinos, Epaminondas ;
Filntisis, Georgios ;
Zakynthinos, Spyros ;
Koutsoukou, Antonia ;
Saroglou, Georgios ;
Nikolaou, Charikleia ;
Vlachogianni, Glykeria ;
Pnevmatikos, Ioannis ;
Mandragos, Konstantinos ;
Kremer, Ildiko ;
Rozgonyi, Zsolt Dezso ;
Marjanek, Zsuzsa ;
Martin-Loeches, Ignacio ;
Singer, Pierre ;
Van Heerden, Vernon ;
Carmeli, Yehuda ;
Povoa, Pedro ;
AlvarezSeoane, Antonio ;
Moura, Pedro ;
Gonzalez, Filipe ;
Ramirez, Paula ;
Torres Marti, Antonio ;
Ferrer Roca, Ricard ;
Oteiza, Lorena ;
Escudero, Dolores ;
Piacentini, Enrique ;
Vera-Artazcoz, Paula (Institut d'Investigació Biomèdica Sant Pau) ;
Tamayo, Luis ;
Gonzalez Gallego, Miguel Angel ;
Suberviola Canas, Borja ;
Figueira, Iglesias ;
Leon, Rafael ;
Korten, Volkan ;
Akova, Murat ;
Wyncoll, Duncan ;
Whitehouse, Tony ;
Hopkins, Phil ;
Sim, Malcolm ;
Golan, Yoav ;
Zervos, Marcus ;
Vazquez, Jose ;
Cherabuddi, Kartikeya ;
Smulian, George ;
Rouphael, Nadine ;
Welker, James ;
Sims, Mathew ;
Van Duin, David ;
McCarthy, Todd ;
Polk, Christopher
Background: Ventilator-associated pneumonia caused by Pseudomonas aeruginosa (PA) in hospitalised patients is associated with high mortality. The effectiveness of the bivalent, bispecific mAb MEDI3902 (gremubamab) in preventing PA nosocomial pneumonia was assessed in PA-colonised mechanically ventilated subjects. [...]
2022 -  10.1186/s13054-022-04204-9
Critical Care, Vol. 26 Núm. 1 (december 2022) , p. 355
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10 p, 1.2 MB |
Expansion of the Human Phenotype Ontology (HPO) knowledge base and resources
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Köhler, Sebastian (Monarch Initiative) ;
Carmody, Leigh (Jackson Laboratory for Genomic Medicine) ;
Vasilevsky, Nicole (Oregon Health and Science University) ;
Jacobsen, Julius O. B. (Queen Mary University of London) ;
Danis, Daniel (Jackson Laboratory for Genomic Medicine) ;
Gourdine, Jean-Philippe (Oregon Health and Science University) ;
Gargano, Michael A. (Jackson Laboratory for Genomic Medicine) ;
Harris, Nomi (Lawrence Berkeley National Laboratory) ;
Matentzoglu, Nicolas (European Bioinformatics Institute) ;
McMurry, Julie A. (Oregon State University) ;
Osumi-Sutherland, David (European Bioinformatics Institute) ;
Cipriani, Valentina (University College of London) ;
Balhoff, James P. (University of North Carolina at Chapel Hill) ;
Conlin, Tom (Oregon State University) ;
Blau, Hannah (Jackson Laboratory for Genomic Medicine) ;
Baynam, Gareth (Government of Western Australia) ;
Palmer, Richard (Curtin University (Perth, Australia)) ;
Gratian, Dylan (Government of Western Australia) ;
Dawkins, Hugh (Government of Western Australia) ;
Segal, Michael (SimulConsult) ;
Jansen, Anna (UZ Brussel) ;
Muaz, Ahmed (Darlinghurst) ;
Chang, Willie H. (Centre for Computational Medicine. Hospital for Sick Children. Department of Computer Science. University of Toronto) ;
Bergerson, Jenna (National Institutes of Health (Bethesda, Estats Units d'Amèrica)) ;
Laulederkind, Stanley (Marquette University) ;
Yüksel, Z. (Bioscientia GmbH) ;
Beltran i Agulló, Sergi (Universitat Pompeu Fabra) ;
Freeman, Alexandra F. (National Institutes of Health (Bethesda, Estats Units d'Amèrica)) ;
Sergouniotis, Panos (University of Manchester. Manchester Royal Eye Hospital) ;
Durkin, Daniel (Jackson Laboratory for Genomic Medicine) ;
Storm, Andrea L. (National Institutes of Health (Bethesda, Estats Units d'Amèrica)) ;
Hanauer, Marc (INSERM) ;
Brudno, Michael (University of Toronto) ;
Bello, Susan (Jackson Laboratory) ;
Sincan, Murat (Sanford Health) ;
Rageth, Kayli (Sanford Health) ;
Wheeler, Matthew T. (Stanford University School of Medicine) ;
Oegema, Renske (University Medical Center) ;
Lourghi, Halima (INSERM) ;
Della Rocca, Maria G. (National Institutes of Health (Bethesda, Estats Units d'Amèrica)) ;
Thompson, R. (Newcastle University) ;
Castellanos, Francisco (Jackson Laboratory for Genomic Medicine) ;
Priest, James (Stanford University School of Medicine) ;
Cunningham-Rundles, Charlotte (Mount Sinai School of Medicine) ;
Hegde, Ayushi (Jackson Laboratory for Genomic Medicine) ;
Lovering, Ruth Caroline (University College London) ;
Hajek, Catherine (Sanford Imagenetics. Sanford Health) ;
Olry, Annie (INSERM) ;
Notarangelo, Luigi (National Institutes of Health (Bethesda, Estats Units d'Amèrica)) ;
Similuk, Morgan (National Institutes of Health (Bethesda, Estats Units d'Amèrica)) ;
Zhang, Xingmin (Jackson Laboratory for Genomic Medicine) ;
Gómez-Andrés, David (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Lochmüller, Hanns (Ottawa Hospital Research Institute) ;
Dollfus, Hélène (Strasbourg University Hospital) ;
Rosenzweig, Sergio (NIH Clinical Center) ;
Marwaha, Shruti (Stanford University School of Medicine) ;
Rath, Ana (INSERM) ;
Sullivan, Kathleen (University of Pennsylvania Perelman School of Medicine) ;
Smith, Cynthia (Jackson Laboratory) ;
Milner, Joshua D. (National Institute of Allergy and Infectious Diseases (Bethesda, Estats Units d'Amèrica)) ;
Leroux, Dorothée (Strasbourg University Hospital) ;
Boerkoel, Cornelius (Sanford Health) ;
Klion, Amy (National Institutes of Health (Bethesda, Estats Units d'Amèrica)) ;
Carter, Melody C. (National Institutes of Health (Bethesda, Estats Units d'Amèrica)) ;
Groza, Tudor (Darlinghurst) ;
Smedley, Damian (Queen Mary University of London) ;
Haendel, Melissa Anne (Oregon State University) ;
Mungall, Christopher (Lawrence Berkeley National Laboratory) ;
Robinson, Peter N. (University of Connecticut) ;
Universitat Autònoma de Barcelona
The Human Phenotype Ontology (HPO) - a standardized vocabulary of phenotypic abnormalities associated with 7000+ diseases - is used by thousands of researchers, clinicians, informaticians and electronic health record systems around the world. [...]
2019 - 10.1093/nar/gky1105
Nucleic acids research, Vol. 47 Núm. D1 (august 2019) , p. D1018-D1027
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