Resultats globals: 5 registres trobats en 0.02 segons.
Articles, 5 registres trobats
Articles 5 registres trobats  
1.
11 p, 1018.7 KB Evaluation of the immunogenicity and impact on the latent HIV-1 reservoir of a conserved region vaccine, MVA.HIVconsv, in antiretroviral therapy-treated subjects / Hancock, Gemma ; Morón-López, Sara (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Kopycinski, Jakub ; Puertas, Maria C. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Giannoulatou, Eleni (University of New South Wales) ; Rose, Annie ; Salgado, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Hayton, Emma-Jo ; Crook, Alison ; Morgan, Catharine ; Angus, Brian ; Chen, Fabian ; Yang, Hongbing ; Martinez-Picado, Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Hanke, Tomas ; Dorrell, Lucy ; Universitat Autònoma de Barcelona
Introduction : Vaccines may be key components of a curative strategy for HIV-1. We investigated whether a novel immunogen, HIVconsv, designed to re-direct T cell responses to conserved viral epitopes, could impact the HIV-1 reservoir in chronic antiretroviral therapy (ART)-treated subjects when delivered by modified vaccinia virus Ankara (MVA). [...]
2017 - 10.7448/IAS.20.1.21171
Journal of the International AIDS Society, Vol. 20 (may 2017)  
2.
10 p, 868.0 KB Defining the HLA class I-associated viral antigen repertoire from HIV-1-infected human cells / Ternette, Nicola (University of Oxford. The Jenner Institute, Nuffield Department of Medicine) ; Yang, Hongbing (University of Oxford. Nuffield Department of Medicine) ; Partridge, Thomas (University of Oxford. Nuffield Department of Medicine) ; Llano Montero, Anuska (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Cedeño, Samandhy (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Fischer, Roman (University of Oxford. Nuffield Department of Medicine) ; Charles, Philip D. (University of Oxford. Nuffield Department of Medicine) ; Dudek, Nadine L. (Monash University. Department of Biochemistry and Molecular Biology) ; Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Crespo, Manuel (Hospital de la Vall d'Hebron. HIV Unit) ; Fischer, William M. (Los Alamos National Laboratory. Group T-6, Theoretical Biology) ; Korber, Bette T. M. (Los Alamos National Laboratory. Group T-6, Theoretical Biology) ; Nielsen, Morten (Technical University of Denmark. Center for Biological Sequence Analysis) ; Borrow, Persephone (University of Oxford. Nuffield Department of Medicine) ; Purcell, Anthony W. (Monash University. Department of Biochemistry and Molecular Biology) ; Brander, Christian (Institució Catalana de Recerca i Estudis Avançats) ; Dorrell, Lucy (University of Oxford. The Jenner Institute, Nuffield Department of Medicine) ; Kessler, Benedikt M. (University of Oxford. Nuffield Department of Medicine) ; Hanke, Tomáš (University of Oxford. The Jenner Institute, Nuffield Department of Medicine) ; Universitat Autònoma de Barcelona
Recognition and eradication of infected cells by cytotoxic T lymphocytes is a key defense mechanism against intracellular pathogens. High-throughput definition of HLA class I-associated immunopeptidomes by mass spectrometry is an increasingly important analytical tool to advance our understanding of the induction of T-cell responses against pathogens such as HIV-1. [...]
2015 - 10.1002/eji.201545890
European Journal of Immunology, Vol. 46 (november 2015) , p. 60-69  
3.
10 p, 763.1 KB Engineering new mycobacterial vaccine design for HIV-TB pediatric vaccine vectored by lysine auxotroph of BCG / Saubi, Narcís (Universitat de Barcelona. Hospital Clínic. Institut D'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS). AIDS Research Group) ; Gea-Mallorquí, Ester (Universitat de Barcelona. Hospital Clínic. Institut D'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS). AIDS Research Group) ; Ferrer, Pau (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ; Hurtado, Carmen (Universitat de Barcelona. Hospital Clínic. Institut D'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS). AIDS Research Group) ; Sánchez-Úbeda, Sara (Universitat de Barcelona. Hospital Clínic. Institut D'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS). AIDS Research Group) ; Eto, Yoshiki (Universitat de Barcelona. Hospital Clínic. Institut D'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS). AIDS Research Group) ; Gatell, Josep M (Universitat de Barcelona. Hospital Clínic. Institut D'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS). AIDS Research Group) ; Hanke, Tomáš (University of Oxford. Weatherall Institute of Molecular Medicine. MRC Human Immunology Unit) ; Joseph, Joan (Universitat de Barcelona. Hospital Clínic. Institut D'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS). AIDS Research Group)
In this study, we have engineered a new mycobacterial vaccine design by using an antibiotic-free plasmid selection system. We assembled a novel Escherichia coli (E. coli)-mycobacterial shuttle plasmid p2auxo. [...]
2014 - 10.1038/mtm.2014.17
Molecular therapy, Vol. 1 (May 2014) , art. 14017  
4.
22 p, 877.6 KB Identification of effective subdominant anti-HIV-1 CD8+ T cells within entire post-infection and post-vaccination immune responses / Hancock, Gemma (University of Oxford) ; Yang, Hongbing (University of Oxford) ; Yorke, Elisabeth (University of Toronto) ; Wainwright, Emma (Royal Berkshire NHS Foundation Trust (Reading, Gran Bretanya)) ; Bourne, Victoria (University of Oxford) ; Frisbee, Alyse (Duke University (Durham, Estats Units d'Amèrica)) ; Payne, Tamika L. (Duke University (Durham, Estats Units d'Amèrica)) ; Berrong, Mark (Duke University (Durham, Estats Units d'Amèrica)) ; Ferrari, Guido (Duke University (Durham, Estats Units d'Amèrica)) ; Chopera, Denis (University of Cape Town) ; Hanke, Tomas (University of Oxford) ; Mothe, Beatriz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Brander, Christian (Hospital Germans Trias i Pujol) ; McElrath, M. Juliana (Fred Hutchinson Cancer Research Center (Seattle, Estats Units d'Amèrica)) ; McMichael, Andrew (University of Oxford) ; Goonetilleke, Nilu (University of North Carolina School of Medicine) ; Tomaras, Georgia D. (Duke University (North Carolina, Estats Units d'Amèrica)) ; Frahm, Nicole (Fred Hutchinson Cancer Research Center (Seattle, Estats Units d'Amèrica)) ; Dorrell, Lucy (University of Oxford)
Abstract. Defining the components of an HIV immunogen that could induce effective CD8+ T cell responses is critical to vaccine development. We addressed this question by investigating the viral targets of CD8+ T cells that potently inhibit HIV replication in vitro, as this is highly predictive of virus control in vivo. [...]
2015 - 10.1371/journal.ppat.1004658
PLoS pathogens, Vol. 11 Núm. 2 (february 2015)  
5.
23 p, 3.3 MB A human immune data-informed vaccine concept elicits strong and broad T-cell specificities associated with HIV-1 control in mice and macaques / Mothe Pujadas, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Hu, Xintao (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ; Llano Montero, Anuska (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Rosati, Margherita (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ; Olvera, Alex (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Kulkarni, Viraj (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ; Valentin, Antonio (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ; Alicea, Cándido (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ; Pilkington, Guy R. (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ; Sardesai, Niranjan Y. (Inovio Pharmaceuticals) ; Rocafort, Muntsa (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Crespo, Manel (Hospital Universitari Vall d'Hebron) ; Carrillo, Jorge (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Marco, Andrés (Centre Penitenciari d'Homes (Barcelona, Catalunya)) ; Mullins, James I. (University of Washington (Estats Units d'Amèrica)) ; Dorrell, Lucy (John Radcliffe Hospital (Oxford, Regne Unit)) ; Hanke, Tomáš (University of Oxford (Regne Unit)) ; Clotet i Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Pavlakis, George N. (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ; Felber, Barbara K. (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ; Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Universitat Autònoma de Barcelona
BACKGROUND: None of the HIV T-cell vaccine candidates that have reached advanced clinical testing have been able to induce protective T cell immunity. A major reason for these failures may have been suboptimal T cell immunogen designs. [...]
2015 - 10.1186/s12967-015-0392-5
Journal of translational medicine, Vol. 13 Núm. 60 (february 2015)  

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