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Artículos Encontrados 11 registros  1 - 10siguiente  ir al registro:
1.
19 p, 3.7 MB Epigenetic landscape in the kick-and-kill therapeutic vaccine BCN02 clinical trial is associated with antiretroviral treatment interruption (ATI) outcome / Oriol-Tordera, Bruna (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Esteve-Codina, Anna (Universitat Pompeu Fabra) ; Berdasco, Maria (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Rosás-Umbert, Míriam (Aarhus University Hospital (Aarhus, Dinamarca)) ; Gonçalves, Elena (Sorbonne Université) ; Duran-Castells, Clara (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Català-Moll, Francesc (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Llano Montero, Anuska (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Cedeño, Samandhy (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Puertas, Maria C. (CIBERINFEC) ; Tolstrup, Martin (Aarhus University Hospital (Aarhus, Dinamarca)) ; Søgaard, Ole S. (Aarhus University Hospital (Aarhus, Dinamarca)) ; Clotet Sala, Bonaventura (Institut Germans Trias i Pujol) ; Martínez-Picado, Javier (Institució Catalana de Recerca i Estudis Avançats) ; Hanke, Tomáš (Kumamoto University) ; Combadiere, Behazine (Sorbonne Université) ; Paredes, Roger (Institut Germans Trias i Pujol) ; Hartigan-O'Connor, Dennis (UC Davis School of Medicine(Estats Units d'Amèrica)) ; Esteller, M (Universitat de Barcelona. Departament de Ciències Fisiològiques II) ; Meulbroek, Michael (Projecte dels NOMS-Hispanosida, BCN Checkpoint (Barcelona)) ; Calle, M. Luz (Universitat de Vic) ; Sánchez, Alex (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Moltó, José (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Ruiz-Riol, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
European Commission. Horizon 2020 $a The BCN02-trial combined therapeutic vaccination with a viral latency reversing agent (romidepsin, RMD) in HIV-1-infected individuals and included a monitored antiretroviral pause (MAP) as an efficacy read-out identifying individuals with an early or late (< or > 4weeks) viral-rebound. [...]
2022 - 10.1016/j.ebiom.2022.103956
EBioMedicine, Vol. 78 (march 2022)  
2.
3.3 MB HIVconsv Vaccines and Romidepsin in Early-Treated HIV-1-Infected Individuals : Safety, Immunogenicity and Effect on the Viral Reservoir (Study BCN02) / Mothe, Beatriz (Universitat de Vic - Universitat Central de Catalunya) ; Rosás-Umbert, Miriam (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Coll, Pep (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Manzardo, Christian (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Puertas, Maria C.. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Moron-Lopez, Sara (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Llano Montero, Anuska (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Miranda, Cristina (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ; Cedeño, Samandhy (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; López, Miriam (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ; Alarcón-Soto, Yovaninna (Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa) ; Melis, Guadalupe Gómez (Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa) ; Langohr, Klaus (Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa) ; Barriocanal, Ana María (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Toro, Jessica (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ; Ruiz, Irene (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Rovira, Cristina (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Carrillo, Antonio (Institut Germans Trias i Pujol) ; Meulbroek, Michael (BCN Checkpoint. Projecte dels NOMS-Hispanosida) ; Crook, Alison (University of Oxford. The Jenner Institute) ; Wee, Edmund G. (University of Oxford. The Jenner Institute) ; Miró, José M (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Clotet Sala, Bonaventura (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Valle, Marta (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Martinez-Picado, Javier (Institució Catalana de Recerca i Estudis Avançats) ; Hanke, Tomáš (Kumamoto University. Joint Research Center for Human Retrovirus Infection) ; Brander, Christian (Institució Catalana de Recerca i Estudis Avançats) ; Moltó, José (Institut Germans Trias i Pujol)
Kick&kill strategies combining drugs aiming to reactivate the viral reservoir with therapeutic vaccines to induce effective cytotoxic immune responses hold potential to achieve a functional cure for HIV-1 infection. [...]
2020 - 10.3389/fimmu.2020.00823
Frontiers in immunology, Vol. 11 (May 2020) , art. 823  
3.
1.1 MB In vivo Effects of Romidepsin on T-Cell Activation, Apoptosis and Function in the BCN02 HIV-1 Kick&Kill Clinical Trial / Rosás-Umbert, Miriam (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Ruiz-Riol, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Fernández, Marco A. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Marszalek, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Coll, Pep (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Manzardo, Christian (Hospital Clínic i Provincial de Barcelona) ; Cedeño, Samandhy (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Miró, José M. (Hospital Clínic i Provincial de Barcelona) ; Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Hanke, Tomáš (University of Oxford) ; Moltó, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Universitat Autònoma de Barcelona. Departament de Medicina
Romidepsin (RMD) is a well-characterized histone deacetylase inhibitor approved for the treatment of cutaneous T-cell lymphoma. in vitro and in vivo studies have demonstrated that it is able to induce HIV-1 gene expression in latently infected CD4 + T cells from HIV-1 + individuals on suppressive antiretroviral therapy. [...]
2020 - 10.3389/fimmu.2020.00418
Frontiers in immunology, Vol. 11 (march 2020)  
4.
16 p, 2.9 MB Therapeutic Vaccination Refocuses T-cell Responses Towards Conserved Regions of HIV-1 in Early Treated Individuals (BCN 01 study) / Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Manzardo, Christian (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Sánchez-Bernabeu, Álvaro (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Coll, Pep (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Moron-Lopez, Sara (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Puertas, Maria C. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Rosás-Umbert, Miriam (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Cobarsi, Patricia (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Escrig, Roser (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Pérez-Álvarez, Núria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Ruiz, Irene (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Rovira, Cristina (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Meulbroek, Michael (Projecte del Noms, BCN Checkpoint, Barcelona, Spain) ; Crook, Alison (The Jenner Institute, University of Oxford, Oxford, UK) ; Borthwick, Nicola (The Jenner Institute, University of Oxford, Oxford, UK) ; Wee, Edmund G. (The Jenner Institute, University of Oxford, Oxford, UK) ; Yang, Hongbing (Nuffield Department of Medicine and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK) ; Miró, José M (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Dorrell, Lucy (Nuffield Department of Medicine and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK) ; Pérez-Álvarez, Núria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Hanke, Tomáš (International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan) ; Universitat Autònoma de Barcelona
Strong and broad antiviral T-cell responses targeting vulnerable sites of HIV-1 will likely be a critical component for any effective cure strategy. BCN01 trial was a phase I, open-label, non-randomized, multicenter study in HIV-1-positive individuals diagnosed and treated during early HIV-1 infection to evaluate two vaccination regimen arms, which differed in the time (8 versus 24 week) between the ChAdV63. [...]
2019 - 10.1016/j.eclinm.2019.05.009
EClinicalMedicine, Vol. 11 (june 2019) , p. 65-80  
5.
1 p, 240.0 KB Corrigendum to 'Therapeutic vaccination refocuses T-cell responses towards conserved regions of HIV-1 in early treated individuals (BCN 01 study)' EClinicalMedicine 11 (2019) 65-80 / Mothe, Beatriz (Universitat de Vic - Universitat Central de Catalunya) ; Manzardo, Christian (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Sanchez-Bernabeu, Alvaro (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Coll, Pep (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Moron-Lopez, Sara (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Puertas, Maria C.. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Rosás-Umbert, Miriam (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Cobarsi, Patricia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Escrig, Roser (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Pérez-Álvarez, Núria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Ruiz, Irene (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Rovira, Cristina (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Meulbroek, Michael (Projecte del Noms, BCN Checkpoint, Barcelona, Spain) ; Crook, Alison (The Jenner Institute, University of Oxford, Oxford, UK) ; Borthwick, Nicola (The Jenner Institute, University of Oxford, Oxford, UK) ; Wee, Edmund G. (The Jenner Institute, University of Oxford, Oxford, UK) ; Yang, Hongbing (Nuffield Department of Medicine and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK) ; Miró, José M (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Dorrell, Lucy (Nuffield Department of Medicine and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK) ; Pérez-Álvarez, Núria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Hanke, Tomáš (International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan) ; Universitat Autònoma de Barcelona
2020 - 10.1016/j.eclinm.2019.100250
EClinicalMedicine, Vol. 18 (january 2020)  
6.
19 p, 3.7 MB Recombinant BCG expressing HTI prime and recombinant ChAdOx1 boost is safe and elicits HIV-1-specific T-cell responses in BALB/c mice / Kilpeläinen, Athina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Saubi, Narcis (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Guitart, Núria (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Olvera, Alex (Universitat de Vic - Universitat Central de Catalunya) ; Hanke, Tomáš (Kumamoto University. International Research Center of Medical Sciences (IRCMS)) ; Brander, Christian. (AELIX Therapeutics) ; Joseph, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
Despite the availability of anti-retroviral therapy, HIV-1 infection remains a massive burden on healthcare systems. Bacillus Calmette-Guérin (BCG), the only licensed vaccine against tuberculosis, confers protection against meningitis and miliary tuberculosis in infants. [...]
2019 - 10.3390/vaccines7030078
Vaccines, Vol. 7 Núm. 3 (september 2019) , p. 78  
7.
11 p, 1018.7 KB Evaluation of the immunogenicity and impact on the latent HIV-1 reservoir of a conserved region vaccine, MVA.HIVconsv, in antiretroviral therapy-treated subjects / Hancock, Gemma ; Moron-Lopez, Sara (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Kopycinski, Jakub ; Puertas, Maria C.. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Giannoulatou, Eleni (University of New South Wales) ; Rose, Annie ; Salgado, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Hayton, Emma-Jo ; Crook, Alison ; Morgan, Catharine ; Angus, Brian ; Chen, Fabian ; Yang, Hongbing ; Martinez-Picado, Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Hanke, Tomáš ; Dorrell, Lucy ; Universitat Autònoma de Barcelona
Introduction : Vaccines may be key components of a curative strategy for HIV-1. We investigated whether a novel immunogen, HIVconsv, designed to re-direct T cell responses to conserved viral epitopes, could impact the HIV-1 reservoir in chronic antiretroviral therapy (ART)-treated subjects when delivered by modified vaccinia virus Ankara (MVA). [...]
2017 - 10.7448/IAS.20.1.21171
Journal of the International AIDS Society, Vol. 20 (may 2017)  
8.
10 p, 868.0 KB Defining the HLA class I-associated viral antigen repertoire from HIV-1-infected human cells / Ternette, Nicola (University of Oxford. The Jenner Institute, Nuffield Department of Medicine) ; Yang, Hongbing (University of Oxford. Nuffield Department of Medicine) ; Partridge, Thomas (University of Oxford. Nuffield Department of Medicine) ; Llano Montero, Anuska (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Cedeño, Samandhy (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Fischer, Roman (University of Oxford. Nuffield Department of Medicine) ; Charles, Philip D. (University of Oxford. Nuffield Department of Medicine) ; Dudek, Nadine L. (Monash University. Department of Biochemistry and Molecular Biology) ; Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Crespo Casal, Manuel (Hospital Universitari Vall d'Hebron) ; Fischer, William M. (Los Alamos National Laboratory. Group T-6, Theoretical Biology) ; Korber, Bette T. M. (Los Alamos National Laboratory. Group T-6, Theoretical Biology) ; Nielsen, Morten (Technical University of Denmark. Center for Biological Sequence Analysis) ; Borrow, Persephone (University of Oxford. Nuffield Department of Medicine) ; Purcell, Anthony W. (Monash University. Department of Biochemistry and Molecular Biology) ; Brander, Christian (Institució Catalana de Recerca i Estudis Avançats) ; Dorrell, Lucy (University of Oxford. The Jenner Institute, Nuffield Department of Medicine) ; Kessler, Benedikt M. (University of Oxford. Nuffield Department of Medicine) ; Hanke, Tomáš (University of Oxford. The Jenner Institute, Nuffield Department of Medicine) ; Universitat Autònoma de Barcelona
Recognition and eradication of infected cells by cytotoxic T lymphocytes is a key defense mechanism against intracellular pathogens. High-throughput definition of HLA class I-associated immunopeptidomes by mass spectrometry is an increasingly important analytical tool to advance our understanding of the induction of T-cell responses against pathogens such as HIV-1. [...]
2015 - 10.1002/eji.201545890
European Journal of Immunology, Vol. 46 (november 2015) , p. 60-69  
9.
10 p, 763.1 KB Engineering new mycobacterial vaccine design for HIV-TB pediatric vaccine vectored by lysine auxotroph of BCG / Saubi, Narcis (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Gea-Mallorquí, Ester (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Ferrer, Pau (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ; Hurtado, Carmen (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Sánchez-Úbeda, Sara (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Eto, Yoshiki (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Gatell, Josep M.. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Hanke, Tomáš (University of Oxford. Weatherall Institute of Molecular Medicine) ; Joseph, Joan (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
In this study, we have engineered a new mycobacterial vaccine design by using an antibiotic-free plasmid selection system. We assembled a novel Escherichia coli (E. coli)-mycobacterial shuttle plasmid p2auxo. [...]
2014 - 10.1038/mtm.2014.17
Molecular Therapy. Methods & Clinical Development, Vol. 1 (May 2014) , art. 14017  
10.
22 p, 877.6 KB Identification of effective subdominant anti-HIV-1 CD8+ T cells within entire post-infection and post-vaccination immune responses / Hancock, Gemma (University of Oxford) ; Yang, Hongbing (University of Oxford) ; Yorke, Elisabeth (University of Toronto) ; Wainwright, Emma (Royal Berkshire NHS Foundation Trust (Reading, Gran Bretanya)) ; Bourne, Victoria (University of Oxford) ; Frisbee, Alyse (Duke University (Durham, Estats Units d'Amèrica)) ; Payne, Tamika L. (Duke University (Durham, Estats Units d'Amèrica)) ; Berrong, Mark (Duke University (Durham, Estats Units d'Amèrica)) ; Ferrari, Guido (Duke University (Durham, Estats Units d'Amèrica)) ; Chopera, Denis (University of Cape Town) ; Hanke, Tomáš (University of Oxford) ; Mothe, Beatriz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Brander, Christian (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; McElrath, M. Juliana (Fred Hutchinson Cancer Research Center (Seattle, Estats Units d'Amèrica)) ; McMichael, Andrew (University of Oxford) ; Goonetilleke, Nilu (University of North Carolina School of Medicine) ; Tomaras, Georgia D. (Duke University (North Carolina, Estats Units d'Amèrica)) ; Frahm, Nicole (Fred Hutchinson Cancer Research Center (Seattle, Estats Units d'Amèrica)) ; Dorrell, Lucy (University of Oxford)
Abstract. Defining the components of an HIV immunogen that could induce effective CD8+ T cell responses is critical to vaccine development. We addressed this question by investigating the viral targets of CD8+ T cells that potently inhibit HIV replication in vitro, as this is highly predictive of virus control in vivo. [...]
2015 - 10.1371/journal.ppat.1004658
PLOS pathogens, Vol. 11 Núm. 2 (february 2015)  

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1 Hanke, T.
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