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16 p, 2.9 MB |
Therapeutic Vaccination Refocuses T-cell Responses Towards Conserved Regions of HIV-1 in Early Treated Individuals (BCN 01 study)
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Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Manzardo, Christian (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Sánchez-Bernabeu, Álvaro (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Coll, Pep (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Moron-Lopez, Sara (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Puertas, Maria C. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rosás-Umbert, Miriam (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Cobarsi, Patricia (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Escrig, Roser (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Pérez-Álvarez, Núria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ruiz, Irene (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Rovira, Cristina (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Meulbroek, Michael (Projecte del Noms, BCN Checkpoint, Barcelona, Spain) ;
Crook, Alison (The Jenner Institute, University of Oxford, Oxford, UK) ;
Borthwick, Nicola (The Jenner Institute, University of Oxford, Oxford, UK) ;
Wee, Edmund G. (The Jenner Institute, University of Oxford, Oxford, UK) ;
Yang, Hongbing (Nuffield Department of Medicine and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK) ;
Miró, Jose M. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Dorrell, Lucy (Nuffield Department of Medicine and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK) ;
Pérez-Álvarez, Núria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Hanke, Tomáš (International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan) ;
Universitat Autònoma de Barcelona
Strong and broad antiviral T-cell responses targeting vulnerable sites of HIV-1 will likely be a critical component for any effective cure strategy. BCN01 trial was a phase I, open-label, non-randomized, multicenter study in HIV-1-positive individuals diagnosed and treated during early HIV-1 infection to evaluate two vaccination regimen arms, which differed in the time (8 versus 24 week) between the ChAdV63. [...]
2019 -  10.1016/j.eclinm.2019.05.009
EClinicalMedicine, Vol. 11 (june 2019) , p. 65-80
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1 p, 240.0 KB |
Corrigendum to 'Therapeutic vaccination refocuses T-cell responses towards conserved regions of HIV-1 in early treated individuals (BCN 01 study)' EClinicalMedicine 11 (2019) 65-80
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Mothe, Beatriz (Universitat de Vic - Universitat Central de Catalunya) ;
Manzardo, Christian (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Sanchez-Bernabeu, Alvaro (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Coll, Pep (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Moron-Lopez, Sara (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Puertas, Maria C. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rosás-Umbert, Miriam (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Cobarsi, Patricia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Escrig, Roser (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pérez-Álvarez, Núria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ruiz, Irene (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Rovira, Cristina (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Meulbroek, Michael (Projecte del Noms, BCN Checkpoint, Barcelona, Spain) ;
Crook, Alison (The Jenner Institute, University of Oxford, Oxford, UK) ;
Borthwick, Nicola (The Jenner Institute, University of Oxford, Oxford, UK) ;
Wee, Edmund G. (The Jenner Institute, University of Oxford, Oxford, UK) ;
Yang, Hongbing (Nuffield Department of Medicine and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK) ;
Miró, Jose M. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Dorrell, Lucy (Nuffield Department of Medicine and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK) ;
Pérez-Álvarez, Núria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Hanke, Tomáš (International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan) ;
Universitat Autònoma de Barcelona
2020 - 10.1016/j.eclinm.2019.100250
EClinicalMedicine, Vol. 18 (january 2020)
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11 p, 1018.7 KB |
Evaluation of the immunogenicity and impact on the latent HIV-1 reservoir of a conserved region vaccine, MVA.HIVconsv, in antiretroviral therapy-treated subjects
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Hancock, Gemma ;
Moron-Lopez, Sara (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Kopycinski, Jakub ;
Puertas, Maria C. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Giannoulatou, Eleni (University of New South Wales) ;
Rose, Annie ;
Salgado, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Hayton, Emma-Jo ;
Crook, Alison ;
Morgan, Catharine ;
Angus, Brian ;
Chen, Fabian ;
Yang, Hongbing ;
Martinez-Picado, Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Hanke, Tomas ;
Dorrell, Lucy ;
Universitat Autònoma de Barcelona
Introduction : Vaccines may be key components of a curative strategy for HIV-1. We investigated whether a novel immunogen, HIVconsv, designed to re-direct T cell responses to conserved viral epitopes, could impact the HIV-1 reservoir in chronic antiretroviral therapy (ART)-treated subjects when delivered by modified vaccinia virus Ankara (MVA). [...]
2017 - 10.7448/IAS.20.1.21171
Journal of the International AIDS Society, Vol. 20 (may 2017)
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10 p, 868.0 KB |
Defining the HLA class I-associated viral antigen repertoire from HIV-1-infected human cells
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Ternette, Nicola (University of Oxford. The Jenner Institute, Nuffield Department of Medicine) ;
Yang, Hongbing (University of Oxford. Nuffield Department of Medicine) ;
Partridge, Thomas (University of Oxford. Nuffield Department of Medicine) ;
Llano Montero, Anuska (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Cedeño, Samandhy (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Fischer, Roman (University of Oxford. Nuffield Department of Medicine) ;
Charles, Philip D. (University of Oxford. Nuffield Department of Medicine) ;
Dudek, Nadine L. (Monash University. Department of Biochemistry and Molecular Biology) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Crespo, Manuel (Hospital Universitari Vall d'Hebron) ;
Fischer, William M. (Los Alamos National Laboratory. Group T-6, Theoretical Biology) ;
Korber, Bette T. M. (Los Alamos National Laboratory. Group T-6, Theoretical Biology) ;
Nielsen, Morten (Technical University of Denmark. Center for Biological Sequence Analysis) ;
Borrow, Persephone (University of Oxford. Nuffield Department of Medicine) ;
Purcell, Anthony W. (Monash University. Department of Biochemistry and Molecular Biology) ;
Brander, Christian (Institució Catalana de Recerca i Estudis Avançats) ;
Dorrell, Lucy (University of Oxford. The Jenner Institute, Nuffield Department of Medicine) ;
Kessler, Benedikt M. (University of Oxford. Nuffield Department of Medicine) ;
Hanke, Tomáš (University of Oxford. The Jenner Institute, Nuffield Department of Medicine) ;
Universitat Autònoma de Barcelona
Recognition and eradication of infected cells by cytotoxic T lymphocytes is a key defense mechanism against intracellular pathogens. High-throughput definition of HLA class I-associated immunopeptidomes by mass spectrometry is an increasingly important analytical tool to advance our understanding of the induction of T-cell responses against pathogens such as HIV-1. [...]
2015 - 10.1002/eji.201545890
European Journal of Immunology, Vol. 46 (november 2015) , p. 60-69
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10 p, 763.1 KB |
Engineering new mycobacterial vaccine design for HIV-TB pediatric vaccine vectored by lysine auxotroph of BCG
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Saubi, Narcis (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Gea-Mallorquí, Ester (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Ferrer, Pau (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ;
Hurtado, Carmen (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Sánchez-Úbeda, Sara (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Eto, Yoshiki (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Gatell, Josep M (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Hanke, Tomáš (University of Oxford. Weatherall Institute of Molecular Medicine) ;
Joseph, Joan (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
In this study, we have engineered a new mycobacterial vaccine design by using an antibiotic-free plasmid selection system. We assembled a novel Escherichia coli (E. coli)-mycobacterial shuttle plasmid p2auxo. [...]
2014 - 10.1038/mtm.2014.17
Molecular Therapy. Methods & Clinical Development, Vol. 1 (May 2014) , art. 14017
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22 p, 877.6 KB |
Identification of effective subdominant anti-HIV-1 CD8+ T cells within entire post-infection and post-vaccination immune responses
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Hancock, Gemma (University of Oxford) ;
Yang, Hongbing (University of Oxford) ;
Yorke, Elisabeth (University of Toronto) ;
Wainwright, Emma (Royal Berkshire NHS Foundation Trust (Reading, Gran Bretanya)) ;
Bourne, Victoria (University of Oxford) ;
Frisbee, Alyse (Duke University (Durham, Estats Units d'Amèrica)) ;
Payne, Tamika L. (Duke University (Durham, Estats Units d'Amèrica)) ;
Berrong, Mark (Duke University (Durham, Estats Units d'Amèrica)) ;
Ferrari, Guido (Duke University (Durham, Estats Units d'Amèrica)) ;
Chopera, Denis (University of Cape Town) ;
Hanke, Tomas (University of Oxford) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Brander, Christian (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
McElrath, M. Juliana (Fred Hutchinson Cancer Research Center (Seattle, Estats Units d'Amèrica)) ;
McMichael, Andrew (University of Oxford) ;
Goonetilleke, Nilu (University of North Carolina School of Medicine) ;
Tomaras, Georgia D. (Duke University (North Carolina, Estats Units d'Amèrica)) ;
Frahm, Nicole (Fred Hutchinson Cancer Research Center (Seattle, Estats Units d'Amèrica)) ;
Dorrell, Lucy (University of Oxford)
Abstract. Defining the components of an HIV immunogen that could induce effective CD8+ T cell responses is critical to vaccine development. We addressed this question by investigating the viral targets of CD8+ T cells that potently inhibit HIV replication in vitro, as this is highly predictive of virus control in vivo. [...]
2015 - 10.1371/journal.ppat.1004658
PLoS pathogens, Vol. 11 Núm. 2 (february 2015)
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23 p, 3.3 MB |
A human immune data-informed vaccine concept elicits strong and broad T-cell specificities associated with HIV-1 control in mice and macaques
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Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Hu, Xintao (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ;
Llano Montero, Anuska (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rosati, Margherita (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ;
Olvera, Alex (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Kulkarni, Viraj (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ;
Valentin, Antonio (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ;
Alicea, Cándido (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ;
Pilkington, Guy R. (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ;
Sardesai, Niranjan Y. (Inovio Pharmaceuticals) ;
Rocafort, Muntsa (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Crespo, Manel (Hospital Universitari Vall d'Hebron) ;
Carrillo, Jorge (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Marco, Andrés (Centre Penitenciari d'Homes (Barcelona, Catalunya)) ;
Mullins, James I. (University of Washington (Estats Units d'Amèrica)) ;
Dorrell, Lucy (John Radcliffe Hospital (Oxford, Regne Unit)) ;
Hanke, Tomáš (University of Oxford (Regne Unit)) ;
Clotet, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Pavlakis, George N. (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ;
Felber, Barbara K. (National Cancer Institute at Frederick (Frederick, Estats Units d'Amèrica)) ;
Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Universitat Autònoma de Barcelona
BACKGROUND: None of the HIV T-cell vaccine candidates that have reached advanced clinical testing have been able to induce protective T cell immunity. A major reason for these failures may have been suboptimal T cell immunogen designs. [...]
2015 - 10.1186/s12967-015-0392-5
Journal of translational medicine, Vol. 13 Núm. 60 (february 2015)
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