1.
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19 p, 3.7 MB |
Epigenetic landscape in the kick-and-kill therapeutic vaccine BCN02 clinical trial is associated with antiretroviral treatment interruption (ATI) outcome
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Oriol-Tordera, Bruna (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Esteve-Codina, Anna (Universitat Pompeu Fabra) ;
Berdasco, Maria (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Rosás-Umbert, Míriam (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Gonçalves, Elena (Sorbonne Université) ;
Duran-Castells, Clara (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Català-Moll, Francesc (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Llano Montero, Anuska (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Cedeño, Samandhy (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Puertas, Maria C. (CIBERINFEC) ;
Tolstrup, Martin (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Søgaard, Ole S. (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol) ;
Martínez-Picado, Javier (Institució Catalana de Recerca i Estudis Avançats) ;
Hanke, Tomáš (Kumamoto University) ;
Combadiere, Behazine (Sorbonne Université) ;
Paredes, Roger (Institut Germans Trias i Pujol) ;
Hartigan-O'Connor, Dennis (UC Davis School of Medicine(Estats Units d'Amèrica)) ;
Esteller, M (Universitat de Barcelona. Departament de Ciències Fisiològiques II) ;
Meulbroek, Michael (Projecte dels NOMS-Hispanosida, BCN Checkpoint (Barcelona)) ;
Calle, M. Luz (Universitat de Vic) ;
Sánchez, Alex (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Moltó, José (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ruiz-Riol, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
European Commission. Horizon 2020 $a The BCN02-trial combined therapeutic vaccination with a viral latency reversing agent (romidepsin, RMD) in HIV-1-infected individuals and included a monitored antiretroviral pause (MAP) as an efficacy read-out identifying individuals with an early or late (< or > 4weeks) viral-rebound. [...]
2022 - 10.1016/j.ebiom.2022.103956
EBioMedicine, Vol. 78 (march 2022)
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2.
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3.3 MB |
HIVconsv Vaccines and Romidepsin in Early-Treated HIV-1-Infected Individuals : Safety, Immunogenicity and Effect on the Viral Reservoir (Study BCN02)
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Mothe, Beatriz (Universitat de Vic - Universitat Central de Catalunya) ;
Rosás-Umbert, Miriam (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Coll, Pep (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Manzardo, Christian (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Puertas, Maria C.. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Moron-Lopez, Sara (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Llano Montero, Anuska (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Miranda, Cristina (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ;
Cedeño, Samandhy (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
López, Miriam (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ;
Alarcón-Soto, Yovaninna (Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa) ;
Melis, Guadalupe Gómez (Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa) ;
Langohr, Klaus (Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa) ;
Barriocanal, Ana María (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Toro, Jessica (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ;
Ruiz, Irene (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Rovira, Cristina (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Carrillo, Antonio (Institut Germans Trias i Pujol) ;
Meulbroek, Michael (BCN Checkpoint. Projecte dels NOMS-Hispanosida) ;
Crook, Alison (University of Oxford. The Jenner Institute) ;
Wee, Edmund G. (University of Oxford. The Jenner Institute) ;
Miró, José M (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Clotet Sala, Bonaventura (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Valle, Marta (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Martinez-Picado, Javier (Institució Catalana de Recerca i Estudis Avançats) ;
Hanke, Tomáš (Kumamoto University. Joint Research Center for Human Retrovirus Infection) ;
Brander, Christian (Institució Catalana de Recerca i Estudis Avançats) ;
Moltó, José (Institut Germans Trias i Pujol)
Kick&kill strategies combining drugs aiming to reactivate the viral reservoir with therapeutic vaccines to induce effective cytotoxic immune responses hold potential to achieve a functional cure for HIV-1 infection. [...]
2020 - 10.3389/fimmu.2020.00823
Frontiers in immunology, Vol. 11 (May 2020) , art. 823
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3.
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1.1 MB |
In vivo Effects of Romidepsin on T-Cell Activation, Apoptosis and Function in the BCN02 HIV-1 Kick&Kill Clinical Trial
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Rosás-Umbert, Miriam (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ruiz-Riol, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Fernández, Marco A. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Marszalek, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Coll, Pep (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Manzardo, Christian (Hospital Clínic i Provincial de Barcelona) ;
Cedeño, Samandhy (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Miró, José M. (Hospital Clínic i Provincial de Barcelona) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Hanke, Tomáš (University of Oxford) ;
Moltó, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Romidepsin (RMD) is a well-characterized histone deacetylase inhibitor approved for the treatment of cutaneous T-cell lymphoma. in vitro and in vivo studies have demonstrated that it is able to induce HIV-1 gene expression in latently infected CD4 + T cells from HIV-1 + individuals on suppressive antiretroviral therapy. [...]
2020 - 10.3389/fimmu.2020.00418
Frontiers in immunology, Vol. 11 (march 2020)
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4.
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16 p, 2.9 MB |
Therapeutic Vaccination Refocuses T-cell Responses Towards Conserved Regions of HIV-1 in Early Treated Individuals (BCN 01 study)
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Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Manzardo, Christian (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Sánchez-Bernabeu, Álvaro (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Coll, Pep (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Moron-Lopez, Sara (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Puertas, Maria C. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rosás-Umbert, Miriam (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Cobarsi, Patricia (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Escrig, Roser (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Pérez-Álvarez, Núria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ruiz, Irene (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Rovira, Cristina (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Meulbroek, Michael (Projecte del Noms, BCN Checkpoint, Barcelona, Spain) ;
Crook, Alison (The Jenner Institute, University of Oxford, Oxford, UK) ;
Borthwick, Nicola (The Jenner Institute, University of Oxford, Oxford, UK) ;
Wee, Edmund G. (The Jenner Institute, University of Oxford, Oxford, UK) ;
Yang, Hongbing (Nuffield Department of Medicine and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK) ;
Miró, José M (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Dorrell, Lucy (Nuffield Department of Medicine and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK) ;
Pérez-Álvarez, Núria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Hanke, Tomáš (International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan) ;
Universitat Autònoma de Barcelona
Strong and broad antiviral T-cell responses targeting vulnerable sites of HIV-1 will likely be a critical component for any effective cure strategy. BCN01 trial was a phase I, open-label, non-randomized, multicenter study in HIV-1-positive individuals diagnosed and treated during early HIV-1 infection to evaluate two vaccination regimen arms, which differed in the time (8 versus 24 week) between the ChAdV63. [...]
2019 - 10.1016/j.eclinm.2019.05.009
EClinicalMedicine, Vol. 11 (june 2019) , p. 65-80
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5.
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1 p, 240.0 KB |
Corrigendum to 'Therapeutic vaccination refocuses T-cell responses towards conserved regions of HIV-1 in early treated individuals (BCN 01 study)' EClinicalMedicine 11 (2019) 65-80
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Mothe, Beatriz (Universitat de Vic - Universitat Central de Catalunya) ;
Manzardo, Christian (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Sanchez-Bernabeu, Alvaro (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Coll, Pep (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Moron-Lopez, Sara (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Puertas, Maria C.. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rosás-Umbert, Miriam (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Cobarsi, Patricia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Escrig, Roser (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pérez-Álvarez, Núria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ruiz, Irene (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Rovira, Cristina (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Meulbroek, Michael (Projecte del Noms, BCN Checkpoint, Barcelona, Spain) ;
Crook, Alison (The Jenner Institute, University of Oxford, Oxford, UK) ;
Borthwick, Nicola (The Jenner Institute, University of Oxford, Oxford, UK) ;
Wee, Edmund G. (The Jenner Institute, University of Oxford, Oxford, UK) ;
Yang, Hongbing (Nuffield Department of Medicine and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK) ;
Miró, José M (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Dorrell, Lucy (Nuffield Department of Medicine and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK) ;
Pérez-Álvarez, Núria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Hanke, Tomáš (International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan) ;
Universitat Autònoma de Barcelona
2020 - 10.1016/j.eclinm.2019.100250
EClinicalMedicine, Vol. 18 (january 2020)
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19 p, 3.7 MB |
Recombinant BCG expressing HTI prime and recombinant ChAdOx1 boost is safe and elicits HIV-1-specific T-cell responses in BALB/c mice
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Kilpeläinen, Athina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Saubi, Narcis (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Guitart, Núria (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Olvera, Alex (Universitat de Vic - Universitat Central de Catalunya) ;
Hanke, Tomáš (Kumamoto University. International Research Center of Medical Sciences (IRCMS)) ;
Brander, Christian. (AELIX Therapeutics) ;
Joseph, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Despite the availability of anti-retroviral therapy, HIV-1 infection remains a massive burden on healthcare systems. Bacillus Calmette-Guérin (BCG), the only licensed vaccine against tuberculosis, confers protection against meningitis and miliary tuberculosis in infants. [...]
2019 - 10.3390/vaccines7030078
Vaccines, Vol. 7 Núm. 3 (september 2019) , p. 78
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7.
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11 p, 1018.7 KB |
Evaluation of the immunogenicity and impact on the latent HIV-1 reservoir of a conserved region vaccine, MVA.HIVconsv, in antiretroviral therapy-treated subjects
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Hancock, Gemma ;
Moron-Lopez, Sara (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Kopycinski, Jakub ;
Puertas, Maria C.. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Giannoulatou, Eleni (University of New South Wales) ;
Rose, Annie ;
Salgado, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Hayton, Emma-Jo ;
Crook, Alison ;
Morgan, Catharine ;
Angus, Brian ;
Chen, Fabian ;
Yang, Hongbing ;
Martinez-Picado, Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Hanke, Tomáš ;
Dorrell, Lucy ;
Universitat Autònoma de Barcelona
Introduction : Vaccines may be key components of a curative strategy for HIV-1. We investigated whether a novel immunogen, HIVconsv, designed to re-direct T cell responses to conserved viral epitopes, could impact the HIV-1 reservoir in chronic antiretroviral therapy (ART)-treated subjects when delivered by modified vaccinia virus Ankara (MVA). [...]
2017 - 10.7448/IAS.20.1.21171
Journal of the International AIDS Society, Vol. 20 (may 2017)
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8.
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10 p, 868.0 KB |
Defining the HLA class I-associated viral antigen repertoire from HIV-1-infected human cells
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Ternette, Nicola (University of Oxford. The Jenner Institute, Nuffield Department of Medicine) ;
Yang, Hongbing (University of Oxford. Nuffield Department of Medicine) ;
Partridge, Thomas (University of Oxford. Nuffield Department of Medicine) ;
Llano Montero, Anuska (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Cedeño, Samandhy (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Fischer, Roman (University of Oxford. Nuffield Department of Medicine) ;
Charles, Philip D. (University of Oxford. Nuffield Department of Medicine) ;
Dudek, Nadine L. (Monash University. Department of Biochemistry and Molecular Biology) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Crespo Casal, Manuel (Hospital Universitari Vall d'Hebron) ;
Fischer, William M. (Los Alamos National Laboratory. Group T-6, Theoretical Biology) ;
Korber, Bette T. M. (Los Alamos National Laboratory. Group T-6, Theoretical Biology) ;
Nielsen, Morten (Technical University of Denmark. Center for Biological Sequence Analysis) ;
Borrow, Persephone (University of Oxford. Nuffield Department of Medicine) ;
Purcell, Anthony W. (Monash University. Department of Biochemistry and Molecular Biology) ;
Brander, Christian (Institució Catalana de Recerca i Estudis Avançats) ;
Dorrell, Lucy (University of Oxford. The Jenner Institute, Nuffield Department of Medicine) ;
Kessler, Benedikt M. (University of Oxford. Nuffield Department of Medicine) ;
Hanke, Tomáš (University of Oxford. The Jenner Institute, Nuffield Department of Medicine) ;
Universitat Autònoma de Barcelona
Recognition and eradication of infected cells by cytotoxic T lymphocytes is a key defense mechanism against intracellular pathogens. High-throughput definition of HLA class I-associated immunopeptidomes by mass spectrometry is an increasingly important analytical tool to advance our understanding of the induction of T-cell responses against pathogens such as HIV-1. [...]
2015 - 10.1002/eji.201545890
European Journal of Immunology, Vol. 46 (november 2015) , p. 60-69
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10 p, 763.1 KB |
Engineering new mycobacterial vaccine design for HIV-TB pediatric vaccine vectored by lysine auxotroph of BCG
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Saubi, Narcis (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Gea-Mallorquí, Ester (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Ferrer, Pau (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ;
Hurtado, Carmen (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Sánchez-Úbeda, Sara (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Eto, Yoshiki (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Gatell, Josep M.. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Hanke, Tomáš (University of Oxford. Weatherall Institute of Molecular Medicine) ;
Joseph, Joan (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
In this study, we have engineered a new mycobacterial vaccine design by using an antibiotic-free plasmid selection system. We assembled a novel Escherichia coli (E. coli)-mycobacterial shuttle plasmid p2auxo. [...]
2014 - 10.1038/mtm.2014.17
Molecular Therapy. Methods & Clinical Development, Vol. 1 (May 2014) , art. 14017
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22 p, 877.6 KB |
Identification of effective subdominant anti-HIV-1 CD8+ T cells within entire post-infection and post-vaccination immune responses
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Hancock, Gemma (University of Oxford) ;
Yang, Hongbing (University of Oxford) ;
Yorke, Elisabeth (University of Toronto) ;
Wainwright, Emma (Royal Berkshire NHS Foundation Trust (Reading, Gran Bretanya)) ;
Bourne, Victoria (University of Oxford) ;
Frisbee, Alyse (Duke University (Durham, Estats Units d'Amèrica)) ;
Payne, Tamika L. (Duke University (Durham, Estats Units d'Amèrica)) ;
Berrong, Mark (Duke University (Durham, Estats Units d'Amèrica)) ;
Ferrari, Guido (Duke University (Durham, Estats Units d'Amèrica)) ;
Chopera, Denis (University of Cape Town) ;
Hanke, Tomáš (University of Oxford) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Brander, Christian (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
McElrath, M. Juliana (Fred Hutchinson Cancer Research Center (Seattle, Estats Units d'Amèrica)) ;
McMichael, Andrew (University of Oxford) ;
Goonetilleke, Nilu (University of North Carolina School of Medicine) ;
Tomaras, Georgia D. (Duke University (North Carolina, Estats Units d'Amèrica)) ;
Frahm, Nicole (Fred Hutchinson Cancer Research Center (Seattle, Estats Units d'Amèrica)) ;
Dorrell, Lucy (University of Oxford)
Abstract. Defining the components of an HIV immunogen that could induce effective CD8+ T cell responses is critical to vaccine development. We addressed this question by investigating the viral targets of CD8+ T cells that potently inhibit HIV replication in vitro, as this is highly predictive of virus control in vivo. [...]
2015 - 10.1371/journal.ppat.1004658
PLOS pathogens, Vol. 11 Núm. 2 (february 2015)
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