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30 p, 5.9 MB Role of Sulfonylurea Receptor 1 and Glibenclamide in Traumatic Brain Injury : A Review of the Evidence / Jha, Ruchira M. (University of Pittsburgh) ; Bell, Josh (Biogen (Estats Units d'Amèrica)) ; Citerio, Giuseppe (Ospedale San Gerardo (Itàlia)) ; Hemphill, J. Claude (University of California) ; Kimberly, W. Taylor (Massachusetts General Hospital (Boston)) ; Narayan, Raj K. (North Shore University Hospital) ; Sahuquillo Barris, Juan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Sheth, Kevin N. (Yale University School of Medicine) ; Simard, J. Marc (University of Maryland School of Medicine) ; Universitat Autònoma de Barcelona
Cerebral edema and contusion expansion are major determinants of morbidity and mortality after TBI. Current treatment options are reactive, suboptimal and associated with significant side effects. First discovered in models of focal cerebral ischemia, there is increasing evidence that the sulfonylurea receptor 1 (SUR1)-Transient receptor potential melastatin 4 (TRPM4) channel plays a key role in these critical secondary injury processes after TBI. [...]
2020 - 10.3390/ijms21020409
International journal of molecular sciences, Vol. 21 (january 2020)  
Detailed record - Creative Commons

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1 Hemphill, J. Claude
1 Hemphill, J.M.
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