Hernández, Karel - Resultados de la búsqueda - Depósito Digital de Documentos de la UAB

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Artículos, Encontrados 3 registros

Artículos	Encontrados 3 registros

10 p, 4.0 MB

Synthesis of γ-Hydroxy-α-amino Acid Derivatives by Enzymatic Tandem Aldol Addition-Transamination Reactions / Moreno, Carlos J. (Institut de Química Avançada de Catalunya) ; Hernández, Karel (Institut de Química Avançada de Catalunya) ; Charnok, Simon J. (Prozomix Limited West End Industrial Estate) ; Gittings, Samantha (Prozomix Limited West End Industrial Estate) ; Bolte, Michael (Goethe-Universität) ; Joglar, Jesús (Institut de Química Avançada de Catalunya) ; Bujons, Jordi (Institut de Química Avançada de Catalunya) ; Parella Coll, Teodor (Universitat Autònoma de Barcelona. Servei de Ressonància Magnètica Nuclear) ; Clapés, Pere (Institut de Química Avançada de Catalunya)
Three enzymatic routes toward γ-hydroxy-α-amino acids by tandem aldol addition-transamination one-pot two-step reactions are reported. The approaches feature an enantioselective aldol addition of pyruvate to various nonaromatic aldehydes catalyzed by trans - o -hydroxybenzylidene pyruvate hydratase-aldolase (HBPA) from Pseudomonas putida. [...]
2021 - DOI (Digital Object Identifier)

10.1021/acscatal.1c00210
ACS catalysis, Vol. 11, Issue 8 (April 2021) , p. 4660-4669

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6 p, 2.1 MB

Biocatalytic Aldol Addition of Simple Aliphatic Nucleophiles to Hydroxyaldehydes / Roldán, Raquel (Institut de Química Avançada de Catalunya) ; Hernández, Karel (Institut de Química Avançada de Catalunya) ; Joglar, Jesús (Institut de Química Avançada de Catalunya) ; Bujons, Jordi (Institut de Química Avançada de Catalunya) ; Parella Coll, Teodor (Universitat Autònoma de Barcelona. Servei de Ressonància Magnètica Nuclear) ; Sánchez-Moreno, Israel (University Clermont Auvergne, CNRS, SIGMA Clermont) ; Hélaine, Virgil (University Clermont Auvergne, CNRS, SIGMA Clermont) ; Lemaire, Marielle (University Clermont Auvergne, CNRS, SIGMA Clermont) ; Guérard-Hélaine, Christine (University Clermont Auvergne, CNRS, SIGMA Clermont) ; Fessner, Wolf-Dieter (Technische Universität Darmstadt) ; Clapés, Pere (Institut de Química Avançada de Catalunya)
Asymmetric aldol addition of simple aldehydes and ketones to electrophiles is a cornerstone reaction for the synthesis of unusual sugars and chiral building blocks. We investigated -fructose-6-phosphate aldolase from E. [...]
2018 - DOI (Digital Object Identifier)

10.1021/acscatal.8b02486
ACS catalysis, Vol. 8 (08 2018) , p. 8804-8809

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15 p, 3.1 MB

Aldolase-Catalyzed Asymmetric Synthesis of N-Heterocycles by Addition of Simple Aliphatic Nucleophiles to Aminoaldehydes / Roldán, Raquel (Institut de Química Avançada de Catalunya) ; Hernández, Karel (Institut de Química Avançada de Catalunya) ; Joglar, Jesús (Institut de Química Avançada de Catalunya) ; Bujons, Jordi (Institut de Química Avançada de Catalunya) ; Parella Coll, Teodor (Universitat Autònoma de Barcelona. Servei de Ressonància Magnètica Nuclear) ; Fessner, Wolf-Dieter (Technische Universität Darmstadt) ; Clapés, Pere (Institut de Química Avançada de Catalunya)
Nitrogen heterocycles are structural motifs found in many bioactive natural products and of utmost importance in pharmaceutical drug development. In this work, a stereoselective synthesis of functionalized N-heterocycles was accomplished in two steps, comprising the biocatalytic aldol addition of ethanal and simple aliphatic ketones such as propanone, butanone, 3-pentanone, cyclobutanone, and cyclopentanone to N -Cbz-protected aminoaldehydes using engineered variants of -fructose-6-phosphate aldolase from Escherichia coli (FSA) or 2-deoxy--ribose-5-phosphate aldolase from Thermotoga maritima (DERA) as catalysts. [...]
2019 - DOI (Digital Object Identifier)

10.1002/adsc.201801530
Advanced synthesis & catalysis, Vol. 361, Issue 11 (January 2019) , p. 2673-2687

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Vea también: autores con nombres similares
4	Hernandez, Karel
1	Hernández, K.

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