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1.
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16 p, 6.8 MB |
Aberrant perineuronal nets alter spinal circuits, impair motor function, and increase plasticity
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Sánchez-Ventura, Judith (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Canal Capdevila, Carla (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Hidalgo Pareja, Juan (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Penas Pérez, Clara (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Navarro, X. (Xavier) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Torres Espín, Abel (University of California. Department of Neurological Surgery) ;
Fouad, K (University of Alberta. Department of Physical Therapy) ;
Udina i Bonet, Esther (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Universitat Autònoma de Barcelona.
Institut de Neurociències
Perineuronal nets (PNNs) are a specialized extracellular matrix that have been extensively studied in the brain. Cortical PNNs are implicated in synaptic stabilization, plasticity inhibition, neuroprotection, and ionic buffering. [...]
2022 -  10.1016/j.expneurol.2022.114220
Experimental Neurology, Vol. 358 (2022) , art. 114220
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2.
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0 p, 3.6 MB |
Bone marrow endothelial dysfunction promotes myeloid cell expansion in cardiovascular disease
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Rohde, David (Massachusetts General Hospital and Harvard Medical School) ;
Vandoorne, Katrien (Massachusetts General Hospital and Harvard Medical School) ;
Lee, I-Hsiu (Department of Radiology, Massachusetts General Hospital) ;
Grune, Jana (Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA) ;
Zhang, Shuang (Department of Radiology, Massachusetts General Hospital) ;
McAlpine, Cameron S. (Department of Radiology, Massachusetts General Hospital) ;
Schloss, Maximilian J. (Department of Radiology, Massachusetts General Hospital) ;
Nayar, Ribhu (Department of Radiology, Massachusetts General Hospital) ;
Courties, Gabriel (Department of Radiology, Massachusetts General Hospital) ;
Frodermann, Vanessa (Department of Radiology, Massachusetts General Hospital) ;
Wojtkiewicz, Gregory (Massachusetts General Hospital) ;
Honold, Lisa (Department of Radiology, Massachusetts General Hospital) ;
Chen, Qi (Max Planck Institute for Molecular Biomedicine, Muenster, Germany) ;
Schmidt, Stephen (Massachusetts General Hospital) ;
Iwamoto, Yoshiko (Massachusetts General Hospital) ;
Sun, Yuan (Department of Radiology, Massachusetts General Hospital) ;
Cremer, Sebastian (Department of Radiology, Massachusetts General Hospital) ;
Hoyer, Friedrich F. (Department of Radiology, Massachusetts General Hospital) ;
Iborra Egea, Oriol (Institut Germans Trias i Pujol) ;
Muñoz-Guijosa, Christian (Institut Germans Trias i Pujol) ;
Ji, Fei (Department of Molecular Biology, Massachusetts General Hospital) ;
Zhou, Bin (Chinese Academy of Sciences) ;
Adams, Ralf H. (Max Planck Institute for Molecular Biomedicine (Alemanya)) ;
Wythe, Joshua D. (Department of Molecular Physiology and Biophysics, Baylor College of Medicine (Estats Units d'Amèrica)) ;
Hidalgo Pareja, Juan (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Watanabe, Hideto (Aichi Medical University) ;
Jung, Yookyung (Massachusetts General Hospital) ;
van der Laan, Anja M. (Department of Cardiology, University of Amsterdam) ;
Piek, Jan J. (Department of Cardiology, University of Amsterdam) ;
Kfoury, Youmna (Department of Stem Cell and Regenerative Biology, Harvard University) ;
Désogère, Pauline A. (Department of Radiology, Massachusetts General Hospital and Harvard Medical School) ;
Vinegoni, Claudio (Department of Radiology, Massachusetts General Hospital) ;
Dutta, Partha (Department of Medicine, University of Pittsburgh School of Medicine) ;
Sadreyev, Ruslan I. (Department of Pathology, Massachusetts General Hospital and Harvard Medical School) ;
Caravan, Peter (Department of Radiology, Massachusetts General Hospital and Harvard Medical School) ;
Bayés-Genís, Antoni (Institut Germans Trias i Pujol) ;
Libby, Peter (Department of Medicine, Brigham and Women's Hospital) ;
Scadden, David T. (Department of Stem Cell and Regenerative Biology, Harvard University) ;
Lin, Charles P. (Aichi Medical University) ;
Naxerova, Kamila (Department of Radiology, Massachusetts General Hospital) ;
Swirski, Filip K. (Department of Radiology, Massachusetts General Hospital) ;
Nahrendorf, Matthias (Department of Internal Medicine I, University Hospital Wuerzburg)
Abnormal hematopoiesis advances cardiovascular disease by generating excess inflammatory leukocytes that attack the arteries and the heart. The bone marrow niche regulates hematopoietic stem cell proliferation and hence the systemic leukocyte pool, but whether cardiovascular disease affects the hematopoietic organ's microvasculature is unknown. [...]
2021 - 10.1038/s44161-021-00002-8
Nature cardiovascular research, Vol. 1 (december 2021) , p. 28-44
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3.
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34 p, 4.1 MB |
Riverhood : political ecologies of socionature commoning and translocal struggles for water justice
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Boelens, Rutgerd (Wageningen University. Department Environmental Sciences) ;
Escobar, Arturo (University of North Carolina. Department of Anthropology) ;
Bakker, Karen (University of British Columbia. Department of Geography) ;
Hommes, Lena (Wageningen University. Department of Environmental Sciences) ;
Swyngedouw, Erik (University of Manchester. Department of Geography) ;
Hogenboom, Barbara (University of Amsterdam) ;
Huijbens, Edward H. (Wageningen University. Department of Environmental Sciences) ;
Jackson, Sue (Griffith University) ;
Vos, Jeroen (Wageningen University. Department of Environmental Sciences) ;
Harris, Leila M. (University of British Columbia) ;
Joy, K.j. (Society for Promoting Participative Ecosystem Management) ;
De castro, Fabio (University of Amsterdam) ;
Duarte-Abadía, Bibiana (Wageningen University. Department of Environmental Sciences) ;
Tubino de souza, Daniele (Wageningen University. Department of Environmental Sciences) ;
Lotz-Sisitka, Heila (Rhodes University. Department of Transformative Social Learning and Sustainability) ;
Hernández-Mora, Nuria (New Water Culture Foundation) ;
Martínez Alier, Joan (Universitat Autònoma de Barcelona. Departament d'Economia i d'Història Econòmica) ;
Roca-Servat, Denisse (Universidad Pontificia Bolivariana) ;
Perreault, Tom (Syracuse University. Department of Geography) ;
Sanchis-Ibor, Carles (Valencian Centre for Irrigation Studies) ;
Suhardiman, Diana (Royal Netherlands Institute of Southeast Asian and Caribbean Studies) ;
Ulloa, Astrid (Universidad Nacional de Colombia. Department of Geography) ;
Wals, Arjen (Wageningen University. Department of Social Sciences) ;
Hoogesteger, Jaime (Wageningen University. Department of Environmental Sciences) ;
Hidalgo-Bastidas, Juan Pablo (Wageningen University. Department of Environmental Sciences) ;
Roa-Avendaño, Tatiana (University of Amsterdam, Amsterdam) ;
Veldwisch, Gert Jan (Wageningen University, Wageningen. Department of Environmental Sciences) ;
Woodhouse, Phil (University of Manchester) ;
Wantzen, Karl M. (UNESCO) ;
Universitat Autònoma de Barcelona.
Institut de Ciència i Tecnologia Ambientals
Mega-damming, pollution and depletion endanger rivers worldwide. Meanwhile, modernist imaginaries of ordering 'unruly waters and humans' have become cornerstones of hydraulic-bureaucratic and capitalist development. [...]
2023 - 10.1080/03066150.2022.2120810
The Journal of peasant studies, Vol. 50, Issue 3 (November 2023) , p. 1125-1156
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4.
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13 p, 8.3 MB |
Microglial response promotes neurodegeneration in the Ndufs4 KO mouse model of Leigh syndrome
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Aguilar Ludwig, Kevin (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Comes, Gemma (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Canal Capdevila, Carla (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Quintana Romero, Albert (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Sanz, Elisenda (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Hidalgo Pareja, Juan (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Leigh syndrome is a mitochondrial disease characterized by neurodegeneration, neuroinflammation, and early death. Mice lacking NDUFS4, a mitochondrial complex I subunit (Ndufs4 KO mice), have been established as a good animal model for studying human pathology associated with Leigh syndrome. [...]
2022 - 10.1002/glia.24234
GLIA, Vol. 70, Issue 11 (November 2022) , p. 2032-2044
2 documentos
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5.
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14 p, 2.5 MB |
CXCL12-abundant reticular cells are the major source of IL-6 upon LPS stimulation and thereby regulate hematopoiesis
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Gerosa, Rahel C. (University of Zurich) ;
Boettcher, Steffen (University of Zurich) ;
Kovtonyuk, Larisa V. (University of Zurich and University Hospital Zurich) ;
Hausmann, Annika (The Institute of Microbiology) ;
Hardt, Wolf-Dietrich (The Institute of Microbiology) ;
Hidalgo Pareja, Juan (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Nombela-Arrieta, César (University of Zurich) ;
Manz, Markus G. (University of Zurich)
Hematopoiesis is maintained by hematopoietic stem and progenitor cells that are located in the bone marrow (BM) where they are embedded within a complex supportive microenvironment consisting of a multitude of various non-hematopoietic and hematopoietic cell types. [...]
2021 - 10.1182/bloodadvances.2021005531
Blood advances, Vol. 5 (december 2021) , p. 5002-5015
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6.
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11 p, 4.9 MB |
Pleiotropic Effect of IL-6 Produced by B-Lymphocytes During Early Phases of Adaptive Immune Responses Against TB Infection
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Linge, Irina (Central Institute for Tuberculosis (Rússia)) ;
Tsareva, Anastasiya (Central Institute for Tuberculosis (Rússia)) ;
Kondratieva, Elena (Central Institute for Tuberculosis (Rússia)) ;
Dyatlov, Alexander (Central Institute for Tuberculosis (Rússia)) ;
Hidalgo Pareja, Juan (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Zvartsev, Ruslan (Russian Academy of Sciences) ;
Apt, Alexander (Central Institute for Tuberculosis (Rússia))
The role of B cells migrating to the lung and forming follicles during tuberculosis (TB) inflammation is still the subject of debate. In addition to their antibody production and antigen-presenting functions, B cells secrete different cytokines and chemokines, thus participating in complex networks of innate and adaptive immunity. [...]
2022 - 10.3389/fimmu.2022.750068
Frontiers in immunology, Vol. 13 (january 2022)
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7.
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2.5 MB |
Non-redundant functions of IL-6 produced by macrophages and dendritic cells in allergic airway inflammation
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Gubernatorova, Ekaterina O. (Russian Academy of Sciences. Engelhardt Institute of Molecular Biology) ;
Gorshkova, Ekaterina A. (Russian Academy of Sciences. Engelhardt Institute of Molecular Biology) ;
Namakanova, Olga A. (Russian Academy of Sciences. Engelhardt Institute of Molecular Biology) ;
Zvartsev, Ruslan (Russian Academy of Sciences. Engelhardt Institute of Molecular Biology) ;
Hidalgo Pareja, Juan (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Drutskaya, Marina S. (Lomonosov Moscow State University) ;
Tumanov, Alexei V. (University of Texas Health Science Center at San Antonio. Department of Microbiology, Immunology and Molecular Genetics) ;
Nedospasov, Sergei A. (Lomonosov Moscow State University)
Asthma is a common inflammatory disease of the airway caused by a combination of genetic and environmental factors and characterized by airflow obstruction, wheezing, eosinophilia, and neutrophilia of lungs and sputum. [...]
2018 - 10.3389/fimmu.2018.02718
Frontiers in immunology, Vol. 9 (November 2018) , art. 2718
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8.
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15 p, 3.7 MB |
Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α
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Wang, Qirui (Southern Medical University. School of Traditional Chinese Medicine) ;
He, Zhenqiang (Sun Yat-sen University Cancer Center. Department of Neurosurgery) ;
Huang, Menggui (University of Pennsylvania Perelman School of Medicine. Department of Radiation Oncology) ;
Liu, Tianrun (The Sixth Affiliated Hospital of Sun Yat-sen University. Department of Otorhinolaryngology) ;
Wang, Yanling (University of Pennsylvania Perelman School of Medicine. Department of Radiation Oncology) ;
Xu, Haineng (University of Pennsylvania Perelman School of Medicine. Department of Radiation Oncology) ;
Duan, Hao (Sun Yat-sen University Cancer Center. Department of Neurosurgery) ;
Ma, Peihong (University of Pennsylvania Perelman School of Medicine. Department of Radiation Oncology) ;
Zhang, Lin (University of Pennsylvania Perelman School of Medicine. Department of Obstetrics and Gynecology) ;
Zamvil, Scott S. (University of California at San Francisco. Department of Neurology and Program in Immunology) ;
Hidalgo Pareja, Juan (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Zhang, Zhenfeng (Second Affiliated Hospital of Guangzhou Medical University. Department of Radiology The) ;
O'Rourke, Donald M. (University of Pennsylvania Perelman School of Medicine. Department of Neurosurgery) ;
Dahmane, Nadia (University of Pennsylvania Perelman School of Medicine. Department of Neurosurgery) ;
Brem, Steven (University of Pennsylvania Perelman School of Medicine. Department of Neurosurgery) ;
Mou, Yonggao (Sun Yat-sen University Cancer Center. Department of Neurosurgery) ;
Gong, Yanqing (University of Pennsylvania Perelman School of Medicine. Department of Medicine) ;
Fan, Yi (University of Pennsylvania Perelman School of Medicine. Department of Neurosurgery)
Spatiotemporal regulation of tumor immunity remains largely unexplored. Here we identify a vascular niche that controls alternative macrophage activation in glioblastoma (GBM). We show that tumor-promoting macrophages are spatially proximate to GBM-associated endothelial cells (ECs), permissive for angiocrine-induced macrophage polarization. [...]
2018 - 10.1038/s41467-018-03050-0
Nature communications, Vol. 9 (February 2018) , art. 559
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9.
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17 p, 6.0 MB |
A new mouse model to study restoration of interleukin-6 (IL-6) expression in a Cre-dependent manner : microglial IL-6 regulation of experimental autoimmune encephalomyelitis
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Sanchis, Paula (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Fernandez-Gayol, Olaya (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Comes, Gemma (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Aguilar Ludwig, Kevin (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Escrig, Anna (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Giralt, Mercedes (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Palmiter, Richard D. (University of Washington. Department of Biochemistry) ;
Hidalgo Pareja, Juan (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Interleukin-6 (IL-6) is a pleiotropic cytokine that controls numerous physiological processes both in basal and neuroinflammatory conditions, including the inflammatory response to experimental autoimmune encephalomyelitis (EAE). [...]
2020 - 10.1186/s12974-020-01969-0
Journal of neuroinflammation, Vol. 17 (October 2020) , art. 304
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10.
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15 p, 2.3 MB |
IL-6 Trans-Signaling in the Brain Influences the Metabolic Phenotype of the 3xTg-AD Mouse Model of Alzheimer's Disease
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Escrig, Anna (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Molinero, Amalia (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Méndez, Brenda (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Giralt, Mercedes (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Comes, Gemma (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Sanchis, Paula (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Fernandez-Gayol, Olaya (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Gimenez-Llort, Lydia (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Becker-Pauly, Christoph (Christian-Albrechts-Universität zu Kiel (Alemanya)) ;
Rose-John, Stefan (Christian-Albrechts-Universität zu Kiel (Alemanya)) ;
Hidalgo Pareja, Juan (Universitat Autònoma de Barcelona. Institut de Neurociències)
Alzheimer's disease (AD) is a neurodegenerative disorder that causes the most prevalent dementia in the elderly people. Obesity and insulin resistance, which may cause major health problems per se, are risk factors for AD, and cytokines such as interleukin-6 (IL-6) have a role in these conditions. [...]
2020 - 10.3390/cells9071605
Cells, Vol. 9 (july 2020)
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